Danio rerio

0 known processes

nlgn2b

neuroligin 2b

(Aliases: nlgn2a)

nlgn2b biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
membrane hyperpolarization GO:0060081 1 0.879
glutamate receptor signaling pathway GO:0007215 1 0.793
regulation of postsynaptic membrane potential GO:0060078 1 0.792
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 1 0.785
regulation of synapse organization GO:0050807 3 0.647
cellular component maintenance GO:0043954 3 0.596
neuron neuron synaptic transmission GO:0007270 1 0.581
regulation of receptor activity GO:0010469 2 0.563
regulation of dendrite development GO:0050773 3 0.535
regulation of synaptic plasticity GO:0048167 1 0.498
regulation of transmembrane transporter activity GO:0022898 2 0.458
response to light stimulus GO:0009416 46 0.425
regulation of ion transmembrane transporter activity GO:0032412 2 0.421
neuron development GO:0048666 262 0.415
cognition GO:0050890 1 0.409
adult behavior GO:0030534 2 0.366
signal transduction GO:0007165 455 0.365
regulation of ion transmembrane transport GO:0034765 18 0.346
positive regulation of response to stimulus GO:0048584 80 0.311
positive regulation of transport GO:0051050 2 0.311
cell surface receptor signaling pathway GO:0007166 325 0.308
larval development GO:0002164 2 0.306
regulation of transmembrane transport GO:0034762 18 0.271
visual behavior GO:0007632 10 0.251
response to radiation GO:0009314 51 0.251
regulation of glutamate receptor signaling pathway GO:1900449 1 0.246
postsynaptic membrane organization GO:0001941 3 0.245
single organism transport GO:0044765 206 0.203
neuron projection morphogenesis GO:0048812 161 0.199
cell morphogenesis involved in differentiation GO:0000904 195 0.180
multi organism process GO:0051704 134 0.174
neuron differentiation GO:0030182 353 0.170
positive regulation of cellular process GO:0048522 201 0.169
regulation of inhibitory postsynaptic membrane potential GO:0060080 1 0.166
cell projection organization GO:0030030 284 0.165
cell projection morphogenesis GO:0048858 244 0.164
single organism localization GO:1902578 225 0.160
cellular component morphogenesis GO:0032989 336 0.160
nitrogen compound metabolic process GO:0006807 319 0.160
regulation of dendrite morphogenesis GO:0048814 3 0.159
synapse assembly GO:0007416 9 0.158
establishment of localization GO:0051234 244 0.153
regulation of transporter activity GO:0032409 2 0.149
synaptic growth at neuromuscular junction GO:0051124 2 0.145
ion transmembrane transport GO:0034220 91 0.145
developmental growth GO:0048589 166 0.141
neuron projection development GO:0031175 180 0.139
cell part morphogenesis GO:0032990 246 0.137
response to abiotic stimulus GO:0009628 122 0.137
transmembrane transport GO:0055085 120 0.135
regulation of multicellular organismal development GO:2000026 223 0.128
regulation of nervous system development GO:0051960 90 0.125
regulation of cell projection organization GO:0031344 44 0.124
positive regulation of biological process GO:0048518 253 0.124
generation of neurons GO:0048699 385 0.123
transport GO:0006810 220 0.123
cellular component assembly GO:0022607 170 0.123
ribonucleotide biosynthetic process GO:0009260 20 0.122
response to amino acid GO:0043200 2 0.121
regulation of synapse structure and activity GO:0050803 5 0.118
negative regulation of cellular process GO:0048523 283 0.118
regulation of signal transduction GO:0009966 225 0.117
regulation of membrane potential GO:0042391 23 0.114
regulation of ion transport GO:0043269 22 0.112
neurological system process GO:0050877 62 0.109
cell morphogenesis GO:0000902 289 0.108
response to external stimulus GO:0009605 264 0.106
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.105
regulation of neuron differentiation GO:0045664 56 0.097
positive regulation of cell communication GO:0010647 56 0.095
regulation of multicellular organismal process GO:0051239 277 0.092
regulation of signaling GO:0023051 235 0.085
regulation of developmental process GO:0050793 247 0.084
regulation of cellular component organization GO:0051128 86 0.082
positive regulation of signaling GO:0023056 56 0.081
response to stress GO:0006950 263 0.080
regulation of neuron projection development GO:0010975 40 0.080
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 5 0.079
nucleocytoplasmic transport GO:0006913 4 0.076
positive regulation of cellular component biogenesis GO:0044089 3 0.075
regulation of neurogenesis GO:0050767 87 0.075
central nervous system development GO:0007417 387 0.074
regulation of response to stimulus GO:0048583 269 0.073
regulation of system process GO:0044057 40 0.070
regulation of synapse assembly GO:0051963 3 0.070
regulation of molecular function GO:0065009 70 0.069
positive regulation of signal transduction GO:0009967 56 0.068
amide transport GO:0042886 12 0.066
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.065
regulation of biological quality GO:0065008 263 0.063
regulation of transport GO:0051049 45 0.062
developmental maturation GO:0021700 34 0.061
organic substance biosynthetic process GO:1901576 289 0.061
synapse organization GO:0050808 21 0.059
dendrite development GO:0016358 9 0.059
regulation of localization GO:0032879 104 0.058
positive regulation of synapse assembly GO:0051965 1 0.058
negative regulation of biological process GO:0048519 304 0.056
regulation of cell morphogenesis GO:0022604 42 0.056
protein localization to nucleus GO:0034504 3 0.054
endomembrane system organization GO:0010256 13 0.053
cellular component biogenesis GO:0044085 178 0.053
regulation of anatomical structure morphogenesis GO:0022603 130 0.052
membrane organization GO:0061024 21 0.052
glial cell differentiation GO:0010001 42 0.051
single organism membrane organization GO:0044802 20 0.051
regulation of response to nutrient levels GO:0032107 1 0.049
protein import into nucleus GO:0006606 3 0.048
nuclear import GO:0051170 3 0.048
multicellular organism growth GO:0035264 4 0.047
cell cell signaling GO:0007267 52 0.047
peptide transport GO:0015833 1 0.047
development of primary female sexual characteristics GO:0046545 4 0.047
establishment of localization in cell GO:0051649 77 0.046
behavior GO:0007610 74 0.045
cellular macromolecule metabolic process GO:0044260 391 0.045
monoamine transport GO:0015844 1 0.045
single organism behavior GO:0044708 24 0.045
regulation of cell differentiation GO:0045595 142 0.044
response to nitrogen compound GO:1901698 19 0.044
protein modification process GO:0036211 100 0.044
response to endogenous stimulus GO:0009719 83 0.044
negative chemotaxis GO:0050919 1 0.044
purine ribonucleotide biosynthetic process GO:0009152 20 0.042
response to amine GO:0014075 1 0.042
maintenance of location GO:0051235 4 0.042
regulation of cell communication GO:0010646 232 0.041
dendrite guidance GO:0070983 0 0.040
neuromuscular junction development GO:0007528 9 0.040
cellular amine metabolic process GO:0044106 2 0.040
aging GO:0007568 2 0.039
regulation of cell development GO:0060284 100 0.038
regulation of hormone secretion GO:0046883 2 0.038
negative regulation of catabolic process GO:0009895 3 0.037
phosphorylation GO:0016310 69 0.037
phagocytosis GO:0006909 3 0.037
gliogenesis GO:0042063 45 0.037
protein import GO:0017038 3 0.036
cellular response to external stimulus GO:0071496 2 0.036
regulation of protein localization to nucleus GO:1900180 2 0.036
cellular localization GO:0051641 97 0.036
response to amphetamine GO:0001975 1 0.036
tube morphogenesis GO:0035239 349 0.036
response to estrogen GO:0043627 27 0.035
response to drug GO:0042493 3 0.035
negative regulation of secretion by cell GO:1903531 2 0.035
protein targeting to nucleus GO:0044744 3 0.035
nuclear transport GO:0051169 4 0.035
response to food GO:0032094 1 0.034
cellular protein metabolic process GO:0044267 129 0.034
nucleobase containing compound biosynthetic process GO:0034654 205 0.033
female gonad development GO:0008585 4 0.033
modification dependent protein catabolic process GO:0019941 3 0.033
organonitrogen compound metabolic process GO:1901564 74 0.033
system process GO:0003008 185 0.032
nucleic acid metabolic process GO:0090304 244 0.032
response to alkaloid GO:0043279 2 0.032
cellular nitrogen compound metabolic process GO:0034641 290 0.032
oxoacid metabolic process GO:0043436 31 0.031
positive regulation of molecular function GO:0044093 33 0.031
embryonic organ development GO:0048568 381 0.031
sensory perception of chemical stimulus GO:0007606 3 0.030
regulation of multicellular organism growth GO:0040014 4 0.030
small molecule metabolic process GO:0044281 77 0.030
death GO:0016265 121 0.029
regulation of circadian sleep wake cycle GO:0042749 1 0.029
regulation of nucleotide biosynthetic process GO:0030808 15 0.028
heterocycle metabolic process GO:0046483 290 0.028
locomotion GO:0040011 313 0.028
cellular protein catabolic process GO:0044257 4 0.028
catecholamine metabolic process GO:0006584 2 0.028
lipid catabolic process GO:0016042 4 0.028
purine containing compound biosynthetic process GO:0072522 20 0.026
regulation of cytoplasmic transport GO:1903649 4 0.026
mesenchymal cell development GO:0014031 78 0.026
regulation of cellular amine metabolic process GO:0033238 0 0.026
dendrite morphogenesis GO:0048813 5 0.025
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.025
single organism cellular localization GO:1902580 46 0.025
intracellular signal transduction GO:0035556 85 0.025
regulation of purine nucleotide metabolic process GO:1900542 17 0.025
viral process GO:0016032 1 0.025
regulation of nitrogen compound metabolic process GO:0051171 251 0.025
morphogenesis of an epithelium GO:0002009 333 0.025
oligodendrocyte differentiation GO:0048709 23 0.024
hormone secretion GO:0046879 2 0.024
carboxylic acid metabolic process GO:0019752 22 0.024
growth GO:0040007 174 0.024
locomotory behavior GO:0007626 34 0.024
embryonic skeletal system morphogenesis GO:0048704 93 0.024
regulation of protein catabolic process GO:0042176 1 0.024
glucose homeostasis GO:0042593 1 0.023
cellular lipid catabolic process GO:0044242 3 0.023
female sex differentiation GO:0046660 4 0.023
establishment of protein localization to organelle GO:0072594 4 0.022
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.022
organophosphate metabolic process GO:0019637 37 0.022
response to hypoxia GO:0001666 25 0.022
lateral line development GO:0048882 66 0.022
multicellular organismal response to stress GO:0033555 2 0.022
regulation of cytokine production GO:0001817 3 0.022
central nervous system neuron axonogenesis GO:0021955 18 0.022
hemopoiesis GO:0030097 183 0.022
cellular biosynthetic process GO:0044249 286 0.021
meiotic nuclear division GO:0007126 4 0.021
cellular nitrogen compound biosynthetic process GO:0044271 218 0.021
response to decreased oxygen levels GO:0036293 25 0.021
regulation of cellular protein catabolic process GO:1903362 1 0.021
hormone transport GO:0009914 2 0.021
regulation of cyclic nucleotide biosynthetic process GO:0030802 15 0.021
camera type eye development GO:0043010 222 0.021
cellular aromatic compound metabolic process GO:0006725 295 0.021
cell type specific apoptotic process GO:0097285 22 0.020
synaptic transmission GO:0007268 35 0.020
regulation of intracellular protein transport GO:0033157 3 0.020
single organism nuclear import GO:1902593 3 0.020
response to organic substance GO:0010033 153 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.019
single organism metabolic process GO:0044710 217 0.019
protein metabolic process GO:0019538 183 0.019
regulation of establishment of protein localization GO:0070201 4 0.019
neuron death GO:0070997 21 0.019
regulation of protein complex assembly GO:0043254 3 0.019
response to carbohydrate GO:0009743 3 0.019
organic acid metabolic process GO:0006082 31 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
regulation of nucleocytoplasmic transport GO:0046822 2 0.019
autophagy GO:0006914 4 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
negative regulation of reproductive process GO:2000242 3 0.018
guanosine containing compound metabolic process GO:1901068 4 0.018
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.018
neuron apoptotic process GO:0051402 20 0.018
response to glucose GO:0009749 3 0.018
biological adhesion GO:0022610 40 0.018
renal absorption GO:0070293 1 0.018
carbohydrate derivative biosynthetic process GO:1901137 43 0.018
cellular response to extracellular stimulus GO:0031668 2 0.018
g protein coupled receptor signaling pathway GO:0007186 74 0.018
energy reserve metabolic process GO:0006112 2 0.018
cellular protein modification process GO:0006464 100 0.017
negative regulation of hormone secretion GO:0046888 2 0.017
circadian sleep wake cycle GO:0042745 2 0.017
gene expression GO:0010467 252 0.017
regulation of nucleotide metabolic process GO:0006140 17 0.017
cellular response to organic substance GO:0071310 105 0.017
sleep GO:0030431 1 0.017
circadian sleep wake cycle sleep GO:0050802 1 0.017
aromatic compound biosynthetic process GO:0019438 217 0.017
regulation of protein metabolic process GO:0051246 56 0.017
nucleotide biosynthetic process GO:0009165 21 0.017
branching morphogenesis of a nerve GO:0048755 4 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
response to hormone GO:0009725 48 0.016
response to glucocorticoid GO:0051384 1 0.016
response to organic cyclic compound GO:0014070 51 0.016
response to monosaccharide GO:0034284 3 0.016
modification dependent macromolecule catabolic process GO:0043632 3 0.016
catechol containing compound metabolic process GO:0009712 2 0.016
negative regulation of secretion GO:0051048 2 0.016
regulation of metal ion transport GO:0010959 4 0.016
stem cell differentiation GO:0048863 117 0.016
regulation of inflammatory response GO:0050727 2 0.016
regulation of cellular metabolic process GO:0031323 320 0.015
positive regulation of catabolic process GO:0009896 4 0.015
regulation of circadian rhythm GO:0042752 4 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
regulation of camp biosynthetic process GO:0030817 9 0.015
positive regulation of secretion by cell GO:1903532 1 0.015
ubiquitin dependent protein catabolic process GO:0006511 3 0.015
organic cyclic compound metabolic process GO:1901360 301 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.015
cell migration GO:0016477 237 0.015
carbohydrate derivative metabolic process GO:1901135 61 0.015
regulation of protein transport GO:0051223 3 0.015
gastrulation GO:0007369 208 0.015
phosphorus metabolic process GO:0006793 109 0.015
nucleobase containing compound metabolic process GO:0006139 274 0.015
astrocyte differentiation GO:0048708 1 0.015
response to biotic stimulus GO:0009607 97 0.015
cell cell adhesion GO:0098609 6 0.015
synapse maturation GO:0060074 1 0.015
positive regulation of neuron death GO:1901216 1 0.014
negative regulation of protein phosphorylation GO:0001933 4 0.014
response to chemical GO:0042221 320 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.014
positive regulation of cytokine production GO:0001819 2 0.014
regulation of locomotion GO:0040012 55 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
regulation of biosynthetic process GO:0009889 250 0.014
negative regulation of protein transport GO:0051224 3 0.014
protein secretion GO:0009306 1 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
circadian sleep wake cycle process GO:0022410 2 0.014
cellular macromolecule biosynthetic process GO:0034645 224 0.014
positive regulation of inflammatory response GO:0050729 1 0.014
brain development GO:0007420 293 0.013
chemosensory behavior GO:0007635 1 0.013
regulation of cytokine mediated signaling pathway GO:0001959 3 0.013
regulation of calcium ion transport GO:0051924 2 0.013
cellular catabolic process GO:0044248 27 0.013
positive regulation of camp biosynthetic process GO:0030819 2 0.013
macromolecule modification GO:0043412 111 0.013
macromolecule localization GO:0033036 54 0.013
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 1 0.013
axonogenesis GO:0007409 152 0.013
positive regulation of camp metabolic process GO:0030816 2 0.013
cellular respiration GO:0045333 3 0.013
cell substrate adhesion GO:0031589 4 0.013
eye development GO:0001654 277 0.013
negative regulation of programmed cell death GO:0043069 58 0.013
regulation of protein ubiquitination GO:0031396 3 0.013
protein phosphorylation GO:0006468 47 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
regulation of cellular protein metabolic process GO:0032268 52 0.013
regulation of primary metabolic process GO:0080090 311 0.013
negative regulation of macromolecule metabolic process GO:0010605 76 0.013
cell matrix adhesion GO:0007160 4 0.013
mechanosensory behavior GO:0007638 2 0.013
negative regulation of kinase activity GO:0033673 4 0.012
response to hexose GO:0009746 3 0.012
startle response GO:0001964 4 0.012
regulation of response to external stimulus GO:0032101 31 0.012
digestive tract morphogenesis GO:0048546 231 0.012
organ regeneration GO:0031100 1 0.012
regulation of programmed cell death GO:0043067 101 0.012
cellular response to estrogen stimulus GO:0071391 24 0.012
positive regulation of cell cycle GO:0045787 3 0.012
cellular response to oxygen levels GO:0071453 1 0.012
morphogenesis of an epithelial sheet GO:0002011 49 0.012
regulation of neuronal synaptic plasticity GO:0048168 1 0.012
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
amine metabolic process GO:0009308 2 0.012
nuclear migration GO:0007097 3 0.012
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.012
regulation of apoptotic process GO:0042981 98 0.012
negative regulation of multicellular organismal process GO:0051241 69 0.012
forebrain anterior posterior pattern specification GO:0021797 3 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
cellular lipid metabolic process GO:0044255 36 0.012
cell motility GO:0048870 244 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
cellular ketone metabolic process GO:0042180 11 0.012
biosynthetic process GO:0009058 294 0.012
carbohydrate homeostasis GO:0033500 1 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.012
cellular response to starvation GO:0009267 1 0.012
cellular macromolecule localization GO:0070727 21 0.011
ribose phosphate biosynthetic process GO:0046390 20 0.011
organelle assembly GO:0070925 110 0.011
negative regulation of cytokine production GO:0001818 1 0.011
peptidyl serine phosphorylation GO:0018105 1 0.011
apoptotic process GO:0006915 116 0.011
neuron projection extension GO:1990138 45 0.011
head development GO:0060322 303 0.011
regulation of response to extracellular stimulus GO:0032104 1 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.011
dopamine metabolic process GO:0042417 2 0.011
negative regulation of multi organism process GO:0043901 3 0.011
axon development GO:0061564 166 0.011
macromolecule biosynthetic process GO:0009059 227 0.011
central nervous system projection neuron axonogenesis GO:0021952 15 0.011
regulation of macromolecule metabolic process GO:0060255 317 0.011
positive regulation of ras protein signal transduction GO:0046579 1 0.011
regulation of cell death GO:0010941 103 0.011
heterocycle biosynthetic process GO:0018130 215 0.011
regulation of blood vessel size GO:0050880 2 0.011
interspecies interaction between organisms GO:0044419 4 0.011
lateral line system development GO:0048925 76 0.011
regulation of response to stress GO:0080134 36 0.011
purine nucleotide metabolic process GO:0006163 27 0.011
positive regulation of apoptotic signaling pathway GO:2001235 1 0.011
cellular response to nutrient levels GO:0031669 2 0.011
regulation of phosphate metabolic process GO:0019220 43 0.011
tyrosine phosphorylation of stat3 protein GO:0042503 1 0.011
negative regulation of cellular metabolic process GO:0031324 77 0.010
oxidation reduction process GO:0055114 41 0.010
positive regulation of secretion GO:0051047 1 0.010
cellular component assembly involved in morphogenesis GO:0010927 107 0.010
positive regulation of response to external stimulus GO:0032103 9 0.010
negative regulation of cell death GO:0060548 60 0.010
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.010
cellular response to hormone stimulus GO:0032870 39 0.010
cell adhesion GO:0007155 40 0.010
regulation of erk1 and erk2 cascade GO:0070372 4 0.010
positive regulation of metabolic process GO:0009893 108 0.010
embryonic skeletal system development GO:0048706 97 0.010
protein localization GO:0008104 40 0.010
cellular amino acid biosynthetic process GO:0008652 2 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
regulation of tube size GO:0035150 2 0.010
regulation of meiotic cell cycle GO:0051445 1 0.010
regulation of translational initiation GO:0006446 1 0.010
smooth muscle contraction GO:0006939 2 0.010

nlgn2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
autistic disorder DOID:12849 0 0.930
pervasive developmental disorder DOID:0060040 0 0.930
autism spectrum disorder DOID:0060041 0 0.930
disease of mental health DOID:150 0 0.930
developmental disorder of mental health DOID:0060037 0 0.930
disease of anatomical entity DOID:7 0 0.036
nervous system disease DOID:863 0 0.023
disease of cellular proliferation DOID:14566 0 0.011
disease of metabolism DOID:0014667 0 0.011
cancer DOID:162 0 0.010
organ system cancer DOID:0050686 0 0.010