Danio rerio

43 known processes

notch2

notch homolog 2

(Aliases: sb:cb884,notch6)

notch2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic organ development GO:0048568 381 0.988
Zebrafish Mouse Fly
digestive tract morphogenesis GO:0048546 231 0.936
Zebrafish Fly
skeletal system development GO:0001501 181 0.927
neuron differentiation GO:0030182 353 0.923
Zebrafish Fly
cellular component morphogenesis GO:0032989 336 0.917
Zebrafish Fly
response to external stimulus GO:0009605 264 0.908
Mouse Fly
heart development GO:0007507 313 0.873
Human Mouse Fly
neuron projection development GO:0031175 180 0.864
Zebrafish Fly
regulation of epithelial cell proliferation GO:0050678 3 0.864
eye development GO:0001654 277 0.861
Mouse Fly
sensory organ morphogenesis GO:0090596 200 0.853
Mouse Fly
mesenchyme development GO:0060485 127 0.851
negative regulation of cellular process GO:0048523 283 0.850
Human Zebrafish Mouse Fly
gastrulation GO:0007369 208 0.844
Zebrafish
positive regulation of biological process GO:0048518 253 0.830
Human Zebrafish Mouse Fly
embryonic organ morphogenesis GO:0048562 274 0.811
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.810
Mouse Fly
blood vessel morphogenesis GO:0048514 216 0.807
Zebrafish Mouse
brain development GO:0007420 293 0.792
Zebrafish
axon guidance GO:0007411 86 0.779
Fly
negative regulation of gastrulation GO:2000542 11 0.774
regulation of stem cell differentiation GO:2000736 4 0.754
Fly
cell projection organization GO:0030030 284 0.742
Zebrafish Fly
regulation of rna metabolic process GO:0051252 224 0.735
Mouse Fly
cellular component movement GO:0006928 335 0.730
Fly
heart morphogenesis GO:0003007 156 0.725
Human Mouse
tube morphogenesis GO:0035239 349 0.721
Zebrafish Mouse Fly
mesoderm development GO:0007498 88 0.720
Zebrafish Fly
regulation of response to stimulus GO:0048583 269 0.718
Human Mouse Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.708
Mouse Fly
neuron projection guidance GO:0097485 86 0.701
Fly
morphogenesis of an epithelium GO:0002009 333 0.696
Mouse Fly
central nervous system development GO:0007417 387 0.685
Zebrafish
chordate embryonic development GO:0043009 271 0.642
Zebrafish Mouse
axon development GO:0061564 166 0.642
Zebrafish Fly
negative regulation of embryonic development GO:0045992 11 0.632
regulation of embryonic development GO:0045995 47 0.623
Zebrafish
somitogenesis GO:0001756 87 0.621
Zebrafish
notochord development GO:0030903 54 0.614
organic cyclic compound biosynthetic process GO:1901362 223 0.610
Mouse Fly
kidney development GO:0001822 92 0.595
Zebrafish Mouse
head development GO:0060322 303 0.594
camera type eye morphogenesis GO:0048593 108 0.589
Mouse
regulation of primary metabolic process GO:0080090 311 0.577
Mouse Fly
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.574
Zebrafish Fly
neuron projection morphogenesis GO:0048812 161 0.567
Zebrafish Fly
signal transduction GO:0007165 455 0.565
Human Zebrafish Mouse Fly
retina development in camera type eye GO:0060041 146 0.561
cell projection morphogenesis GO:0048858 244 0.560
Zebrafish Fly
response to inorganic substance GO:0010035 38 0.559
blood vessel development GO:0001568 246 0.556
Zebrafish Mouse
cell morphogenesis involved in differentiation GO:0000904 195 0.544
Zebrafish Fly
positive regulation of cellular metabolic process GO:0031325 94 0.541
Fly
positive regulation of cellular process GO:0048522 201 0.538
Human Zebrafish Mouse Fly
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.538
Zebrafish
regulation of developmental process GO:0050793 247 0.530
Zebrafish Mouse Fly
formation of primary germ layer GO:0001704 62 0.524
Zebrafish
pancreas development GO:0031016 84 0.520
Zebrafish
developmental growth involved in morphogenesis GO:0060560 86 0.519
connective tissue development GO:0061448 99 0.513
epithelial cell differentiation GO:0030855 116 0.513
Mouse Fly
cell fate commitment GO:0045165 99 0.508
Zebrafish Rat Worm Fly
taxis GO:0042330 109 0.501
Fly
segmentation GO:0035282 97 0.497
Zebrafish Fly
negative regulation of cell fate specification GO:0009996 11 0.495
positive regulation of stem cell proliferation GO:2000648 1 0.491
single organism metabolic process GO:0044710 217 0.490
regulation of endodermal cell differentiation GO:1903224 15 0.488
Zebrafish
hepaticobiliary system development GO:0061008 98 0.483
regulation of multicellular organismal development GO:2000026 223 0.457
Zebrafish Mouse Fly
cell morphogenesis GO:0000902 289 0.455
Zebrafish Fly
gland development GO:0048732 143 0.455
regulation of macromolecule metabolic process GO:0060255 317 0.441
Mouse Fly
nucleic acid templated transcription GO:0097659 181 0.432
Mouse Fly
organic cyclic compound metabolic process GO:1901360 301 0.426
Mouse Fly
cell proliferation GO:0008283 80 0.423
Human Zebrafish Mouse Worm Fly
cell surface receptor signaling pathway GO:0007166 325 0.416
Zebrafish Mouse Fly
lateral inhibition GO:0046331 1 0.413
Fly
regulation of cell development GO:0060284 100 0.412
Zebrafish Fly
sensory organ development GO:0007423 393 0.409
Mouse Fly
establishment of localization GO:0051234 244 0.405
Zebrafish Mouse Worm
forebrain generation of neurons GO:0021872 14 0.402
chondrocyte development GO:0002063 4 0.400
embryonic camera type eye development GO:0031076 29 0.400
regulation of cellular metabolic process GO:0031323 320 0.388
Mouse Fly
epidermal cell differentiation GO:0009913 36 0.387
angiogenesis GO:0001525 158 0.386
Mouse
cartilage development GO:0051216 96 0.386
apoptotic process GO:0006915 116 0.382
Mouse
heterocycle biosynthetic process GO:0018130 215 0.377
Mouse Fly
somite development GO:0061053 96 0.376
Zebrafish
embryonic skeletal system morphogenesis GO:0048704 93 0.371
eye morphogenesis GO:0048592 144 0.369
Mouse Fly
locomotion GO:0040011 313 0.367
Worm Fly
ear development GO:0043583 127 0.358
neuron development GO:0048666 262 0.349
Zebrafish Fly
anterior posterior pattern specification GO:0009952 152 0.344
Zebrafish Fly
nitrogen compound metabolic process GO:0006807 319 0.342
Mouse Fly
regulation of stem cell proliferation GO:0072091 2 0.336
embryonic heart tube development GO:0035050 133 0.333
Mouse
cellular response to external stimulus GO:0071496 2 0.331
gene expression GO:0010467 252 0.329
Mouse Fly
ear morphogenesis GO:0042471 64 0.327
positive regulation of jnk cascade GO:0046330 3 0.321
positive regulation of signal transduction GO:0009967 56 0.319
Human Mouse Fly
cellular aromatic compound metabolic process GO:0006725 295 0.306
Mouse Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.305
Mouse Fly
endocrine system development GO:0035270 65 0.305
urogenital system development GO:0001655 97 0.303
Zebrafish Mouse Fly
biosynthetic process GO:0009058 294 0.301
Mouse Fly
rna biosynthetic process GO:0032774 181 0.298
Mouse Fly
stem cell proliferation GO:0072089 4 0.297
extrinsic apoptotic signaling pathway GO:0097191 3 0.290
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.289
Fly
morphogenesis of an epithelial sheet GO:0002011 49 0.288
Mouse
inner ear development GO:0048839 126 0.287
negative regulation of cell communication GO:0010648 96 0.284
regulation of cellular component organization GO:0051128 86 0.284
Zebrafish Worm Fly
cell projection assembly GO:0030031 64 0.282
Fly
inner ear receptor cell differentiation GO:0060113 29 0.280
nucleocytoplasmic transport GO:0006913 4 0.277
positive regulation of transcription dna templated GO:0045893 57 0.276
Fly
skeletal system morphogenesis GO:0048705 102 0.274
cell cell signaling involved in cell fate commitment GO:0045168 12 0.273
Worm Fly
death GO:0016265 121 0.269
Mouse
establishment of protein localization to organelle GO:0072594 4 0.268
developmental growth GO:0048589 166 0.264
localization of cell GO:0051674 244 0.263
Fly
chemotaxis GO:0006935 104 0.263
Fly
retinal ganglion cell axon guidance GO:0031290 35 0.261
negative regulation of cell fate commitment GO:0010454 13 0.261
forebrain neuron differentiation GO:0021879 14 0.258
sprouting angiogenesis GO:0002040 53 0.254
cellular nitrogen compound metabolic process GO:0034641 290 0.253
Mouse Fly
generation of neurons GO:0048699 385 0.246
Zebrafish Fly
regulation of chondrocyte differentiation GO:0032330 1 0.246
somatic stem cell maintenance GO:0035019 1 0.244
Zebrafish
single organism transport GO:0044765 206 0.243
Mouse
camera type eye development GO:0043010 222 0.238
Mouse
muscle cell differentiation GO:0042692 139 0.235
Fly
digestive system development GO:0055123 289 0.234
Zebrafish Worm Fly
regulation of cellular biosynthetic process GO:0031326 245 0.233
Mouse Fly
negative regulation of endodermal cell differentiation GO:1903225 8 0.232
cellular nitrogen compound biosynthetic process GO:0044271 218 0.231
Mouse Fly
regulation of signaling GO:0023051 235 0.229
Human Mouse Fly
photoreceptor cell differentiation GO:0046530 55 0.225
Fly
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.225
vasculature development GO:0001944 278 0.224
cilium assembly GO:0042384 58 0.222
regulation of nucleocytoplasmic transport GO:0046822 2 0.221
regulation of cell fate specification GO:0042659 20 0.219
Zebrafish Fly
hematopoietic or lymphoid organ development GO:0048534 191 0.219
Mouse Fly
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.218
regulation of cell death GO:0010941 103 0.217
Mouse
negative regulation of response to stimulus GO:0048585 104 0.215
heart jogging GO:0003146 40 0.213
cell death GO:0008219 121 0.208
Mouse
cell part morphogenesis GO:0032990 246 0.207
Zebrafish Fly
cellular protein metabolic process GO:0044267 129 0.203
Fly
embryonic skeletal system development GO:0048706 97 0.202
positive regulation of stress activated mapk cascade GO:0032874 3 0.201
regulation of gene expression GO:0010468 265 0.201
Mouse Fly
response to chemical GO:0042221 320 0.201
Fly
regulation of biological quality GO:0065008 263 0.201
Zebrafish Fly
glial cell migration GO:0008347 3 0.200
Fly
liver development GO:0001889 96 0.198
regulation of cell substrate adhesion GO:0010810 1 0.197
cellular protein modification process GO:0006464 100 0.193
Fly
bmp signaling pathway GO:0030509 52 0.193
Mouse
radial glial cell differentiation GO:0060019 2 0.192
Zebrafish
regulation of multicellular organismal process GO:0051239 277 0.192
Zebrafish Mouse Fly
negative regulation of stem cell differentiation GO:2000737 2 0.192
regulation of cell communication GO:0010646 232 0.191
Human Mouse Fly
nucleobase containing compound metabolic process GO:0006139 274 0.190
Mouse Fly
immune response GO:0006955 28 0.190
Mouse
positive regulation of cell proliferation GO:0008284 15 0.189
Mouse Fly
central nervous system neuron differentiation GO:0021953 74 0.188
Zebrafish
regulation of organ growth GO:0046620 3 0.187
cellular response to radiation GO:0071478 4 0.183
positive regulation of developmental process GO:0051094 50 0.182
Zebrafish Mouse
aging GO:0007568 2 0.181
Worm Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.179
Mouse Fly
regulation of cell differentiation GO:0045595 142 0.179
Zebrafish Mouse Fly
transport GO:0006810 220 0.178
Zebrafish Mouse Worm
positive regulation of cellular biosynthetic process GO:0031328 68 0.177
Fly
heterocycle metabolic process GO:0046483 290 0.175
Mouse Fly
regulation of rna biosynthetic process GO:2001141 213 0.172
Mouse Fly
cellular response to organic substance GO:0071310 105 0.171
regulation of nucleic acid templated transcription GO:1903506 213 0.170
Mouse Fly
organic substance biosynthetic process GO:1901576 289 0.168
Mouse Fly
digestive tract development GO:0048565 265 0.166
Zebrafish Worm Fly
mesenchymal cell proliferation GO:0010463 1 0.166
growth GO:0040007 174 0.165
muscle fiber development GO:0048747 52 0.165
negative regulation of signaling GO:0023057 96 0.164
regulation of gastrulation GO:0010470 24 0.164
Zebrafish
cellular component biogenesis GO:0044085 178 0.163
Fly
nuclear transport GO:0051169 4 0.160
macromolecule biosynthetic process GO:0009059 227 0.159
Mouse Fly
aromatic compound biosynthetic process GO:0019438 217 0.157
Mouse Fly
positive regulation of response to stimulus GO:0048584 80 0.157
Human Mouse Fly
cranial nerve development GO:0021545 42 0.156
embryonic heart tube morphogenesis GO:0003143 108 0.156
Mouse
appendage morphogenesis GO:0035107 56 0.154
Mouse Fly
multicellular organism growth GO:0035264 4 0.153
regulation of nervous system development GO:0051960 90 0.152
Zebrafish Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.151
Mouse Fly
single organism nuclear import GO:1902593 3 0.150
cell fate specification GO:0001708 68 0.150
Zebrafish Worm Fly
inner ear morphogenesis GO:0042472 63 0.149
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.149
phosphorus metabolic process GO:0006793 109 0.149
Fly
immune system development GO:0002520 191 0.148
Mouse Fly
diencephalon development GO:0021536 58 0.148
Zebrafish
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.147
negative regulation of metabolic process GO:0009892 86 0.146
Mouse Fly
mesenchymal cell differentiation GO:0048762 87 0.145
embryo development ending in birth or egg hatching GO:0009792 271 0.145
Zebrafish Mouse Worm
embryonic eye morphogenesis GO:0048048 30 0.144
endodermal cell fate specification GO:0001714 17 0.143
Zebrafish
regulation of multicellular organism growth GO:0040014 4 0.143
spinal cord radial glial cell differentiation GO:0021531 2 0.142
Zebrafish
bone development GO:0060348 14 0.141
cell migration GO:0016477 237 0.140
Fly
response to molecule of bacterial origin GO:0002237 14 0.140
epithelial tube morphogenesis GO:0060562 148 0.139
Mouse Fly
forebrain development GO:0030900 96 0.137
Zebrafish
positive regulation of cell communication GO:0010647 56 0.136
Human Mouse Fly
positive regulation of biosynthetic process GO:0009891 68 0.136
Fly
response to organic substance GO:0010033 153 0.134
regulation of canonical wnt signaling pathway GO:0060828 34 0.134
positive regulation of epithelial cell proliferation GO:0050679 1 0.133
regulation of developmental growth GO:0048638 38 0.131
renal system development GO:0072001 94 0.131
Zebrafish Mouse Fly
regulation of signal transduction GO:0009966 225 0.128
Human Mouse Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.126
Fly
axonogenesis GO:0007409 152 0.126
Zebrafish Fly
mesenchymal cell development GO:0014031 78 0.124
positive regulation of metabolic process GO:0009893 108 0.124
Fly
negative regulation of multicellular organismal process GO:0051241 69 0.119
Zebrafish Fly
regulation of notch signaling pathway GO:0008593 16 0.119
Fly
muscle organ development GO:0007517 101 0.119
Worm Fly
extracellular structure organization GO:0043062 27 0.119
positive regulation of macromolecule metabolic process GO:0010604 93 0.118
Fly
tissue remodeling GO:0048771 4 0.118
Human
cell motility GO:0048870 244 0.117
Fly
neural crest cell development GO:0014032 62 0.117
regulation of programmed cell death GO:0043067 101 0.117
Mouse
regulation of cytoplasmic transport GO:1903649 4 0.116
tissue homeostasis GO:0001894 25 0.114
single organism localization GO:1902578 225 0.113
Mouse
regulation of neuron differentiation GO:0045664 56 0.113
Fly
regulation of metabolic process GO:0019222 359 0.113
Mouse Fly
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.113
macromolecule modification GO:0043412 111 0.112
Fly
embryonic cranial skeleton morphogenesis GO:0048701 90 0.111
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.109
response to wounding GO:0009611 116 0.109
protein targeting to nucleus GO:0044744 3 0.108
endocardial cushion formation GO:0003272 2 0.108
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.107
specification of organ identity GO:0010092 2 0.105
positive regulation of rna biosynthetic process GO:1902680 57 0.104
Fly
outflow tract morphogenesis GO:0003151 1 0.104
regulation of biosynthetic process GO:0009889 250 0.104
Mouse Fly
protein import into nucleus GO:0006606 3 0.104
small molecule metabolic process GO:0044281 77 0.104
endodermal cell fate commitment GO:0001711 18 0.103
Zebrafish
cell growth GO:0016049 57 0.101
Human
cellular response to extracellular stimulus GO:0031668 2 0.101
erk1 and erk2 cascade GO:0070371 4 0.101
nephron development GO:0072006 31 0.099
Mouse
heart looping GO:0001947 94 0.098
Mouse
regulation of mesenchymal cell proliferation GO:0010464 1 0.098
embryonic limb morphogenesis GO:0030326 2 0.098
Mouse
response to nutrient GO:0007584 3 0.098
mesodermal cell fate specification GO:0007501 12 0.098
Zebrafish
regionalization GO:0003002 274 0.098
Zebrafish Mouse Fly
regulation of erk1 and erk2 cascade GO:0070372 4 0.098
cell substrate adhesion GO:0031589 4 0.096
transcription from rna polymerase ii promoter GO:0006366 80 0.096
Mouse Fly
regulation of endothelial cell proliferation GO:0001936 1 0.096
stem cell maintenance GO:0019827 4 0.096
Zebrafish Fly
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.095
cellular response to chemical stimulus GO:0070887 157 0.094
blood circulation GO:0008015 87 0.094
Zebrafish
regulation of cell fate commitment GO:0010453 22 0.094
Zebrafish Fly
embryonic viscerocranium morphogenesis GO:0048703 52 0.093
positive regulation of nucleic acid templated transcription GO:1903508 57 0.092
Fly
negative regulation of epithelial cell proliferation GO:0050680 1 0.092
negative regulation of endodermal cell fate specification GO:0042664 8 0.092
regulation of transcription dna templated GO:0006355 213 0.091
Mouse Fly
protein modification process GO:0036211 100 0.091
Fly
organelle organization GO:0006996 227 0.091
Worm Fly
regulation of reproductive process GO:2000241 4 0.090
phosphate containing compound metabolic process GO:0006796 108 0.089
Fly
neural crest cell migration GO:0001755 42 0.088
glial cell proliferation GO:0014009 4 0.088
regulation of cell morphogenesis GO:0022604 42 0.088
osteoblast differentiation GO:0001649 5 0.087
negative regulation of macromolecule metabolic process GO:0010605 76 0.087
Mouse Fly
regulation of protein transport GO:0051223 3 0.086
cellular ketone metabolic process GO:0042180 11 0.086
regulation of anatomical structure morphogenesis GO:0022603 130 0.085
Zebrafish Fly
cell adhesion GO:0007155 40 0.085
Fly
negative regulation of signal transduction GO:0009968 94 0.084
endodermal cell differentiation GO:0035987 19 0.082
Zebrafish
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.081
Fly
endocardial cushion development GO:0003197 6 0.081
glucose homeostasis GO:0042593 1 0.081
stem cell development GO:0048864 82 0.081
Zebrafish Fly
endodermal cell fate determination GO:0007493 2 0.081
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.081
olfactory placode development GO:0071698 12 0.079
oocyte maturation GO:0001556 4 0.078
epidermis development GO:0008544 48 0.077
endoderm development GO:0007492 49 0.077
Zebrafish
response to stress GO:0006950 263 0.076
macromolecule localization GO:0033036 54 0.076
Mouse
protein import GO:0017038 3 0.076
endothelial cell proliferation GO:0001935 11 0.075
negative regulation of developmental growth GO:0048640 9 0.075
negative regulation of sequestering of calcium ion GO:0051283 4 0.074
transcription dna templated GO:0006351 181 0.074
Mouse Fly
embryonic camera type eye morphogenesis GO:0048596 19 0.073
cilium morphogenesis GO:0060271 85 0.072
regulation of protein targeting GO:1903533 2 0.072
protein phosphorylation GO:0006468 47 0.072
Fly
mesodermal cell differentiation GO:0048333 21 0.072
Zebrafish
specification of symmetry GO:0009799 204 0.071
Zebrafish Mouse
regulation of cellular component movement GO:0051270 55 0.071
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.071
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.070
cellular response to molecule of bacterial origin GO:0071219 3 0.070
regulation of cell proliferation GO:0042127 37 0.069
Human Mouse Worm Fly
homeostatic process GO:0042592 142 0.069
Fly
vesicle mediated transport GO:0016192 22 0.069
Zebrafish Worm
regulation of protein import into nucleus GO:0042306 2 0.069
response to lipid GO:0033993 60 0.069
protein localization to nucleus GO:0034504 3 0.068
retina morphogenesis in camera type eye GO:0060042 79 0.068
epithelial cell proliferation GO:0050673 17 0.067
Fly
growth plate cartilage development GO:0003417 2 0.067
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.066
morphogenesis of embryonic epithelium GO:0016331 30 0.066
compound eye development GO:0048749 2 0.066
Fly
single organism organelle organization GO:1902589 199 0.065
Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.065
Mouse Fly
system process GO:0003008 185 0.065
Zebrafish Fly
negative regulation of axon extension GO:0030517 7 0.065
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.065
Mouse
regulation of localization GO:0032879 104 0.064
Zebrafish
endocytosis GO:0006897 16 0.064
Zebrafish Worm
positive regulation of cell death GO:0010942 29 0.064
Mouse
regulation of endodermal cell fate specification GO:0042663 15 0.063
Zebrafish
endocrine pancreas development GO:0031018 27 0.063
response to metal ion GO:0010038 34 0.063
positive regulation of transport GO:0051050 2 0.063
developmental cell growth GO:0048588 52 0.063
neuron projection regeneration GO:0031102 16 0.063
regeneration GO:0031099 91 0.063
anatomical structure homeostasis GO:0060249 36 0.062
regulation of intracellular protein transport GO:0033157 3 0.061
positive regulation of neuron apoptotic process GO:0043525 1 0.060
positive regulation of rna metabolic process GO:0051254 59 0.060
Fly
regulation of establishment of protein localization GO:0070201 4 0.060
phosphorylation GO:0016310 69 0.059
Fly
septum transversum development GO:0003343 4 0.059
eye photoreceptor cell differentiation GO:0001754 45 0.059
Fly
positive regulation of response to external stimulus GO:0032103 9 0.059
positive regulation of gene expression GO:0010628 71 0.059
Fly
determination of left right symmetry GO:0007368 179 0.057
Zebrafish Mouse
nerve development GO:0021675 45 0.057
positive regulation of wound healing GO:0090303 1 0.057
atrioventricular valve formation GO:0003190 3 0.056
embryonic camera type eye formation GO:0060900 10 0.056
notch signaling pathway GO:0007219 35 0.056
Zebrafish Fly
regulation of wnt signaling pathway GO:0030111 53 0.056
negative regulation of biological process GO:0048519 304 0.056
Human Zebrafish Mouse Fly
programmed cell death GO:0012501 119 0.056
Mouse
ossification GO:0001503 23 0.055
regulation of synapse assembly GO:0051963 3 0.055
olfactory lobe development GO:0021988 4 0.054
regulation of response to stress GO:0080134 36 0.054
neural retina development GO:0003407 49 0.053
determination of heart left right asymmetry GO:0061371 117 0.053
Mouse
behavior GO:0007610 74 0.053
Worm Fly
cellular response to nutrient levels GO:0031669 2 0.053
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.052
cell differentiation in spinal cord GO:0021515 40 0.052
Zebrafish
regulation of dna replication GO:0006275 3 0.052
neural crest cell differentiation GO:0014033 72 0.052
positive regulation of protein kinase b signaling GO:0051897 1 0.052
response to external biotic stimulus GO:0043207 97 0.051
Mouse Fly
mechanoreceptor differentiation GO:0042490 37 0.050
regulation of cellular ketone metabolic process GO:0010565 7 0.050
phagocytosis GO:0006909 3 0.050
branching morphogenesis of a nerve GO:0048755 4 0.050
motor neuron axon guidance GO:0008045 23 0.049
Fly
cellular amino acid metabolic process GO:0006520 7 0.049
regulation of neurogenesis GO:0050767 87 0.049
Zebrafish Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.049
Mouse Fly
pronephros development GO:0048793 69 0.049
Zebrafish
establishment of localization in cell GO:0051649 77 0.048
Mouse
cellular component assembly GO:0022607 170 0.048
Fly
muscle structure development GO:0061061 196 0.048
Worm Fly
immune system process GO:0002376 241 0.048
Mouse Fly
inner ear receptor cell development GO:0060119 20 0.048
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.048
Fly
negative regulation of reproductive process GO:2000242 3 0.047
multicellular organismal metabolic process GO:0044236 2 0.047
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.046
nucleic acid metabolic process GO:0090304 244 0.045
Mouse Fly
skin morphogenesis GO:0043589 7 0.045
response to vitamin GO:0033273 3 0.045
optic placode formation involved in camera type eye formation GO:0046619 3 0.045
skeletal muscle organ development GO:0060538 78 0.045
Fly
hindbrain development GO:0030902 91 0.044
Zebrafish
protein metabolic process GO:0019538 183 0.044
Fly
regulation of intracellular signal transduction GO:1902531 57 0.044
Human
wnt signaling pathway GO:0016055 80 0.044
olfactory bulb development GO:0021772 4 0.044
regulation of cellular protein metabolic process GO:0032268 52 0.044
negative regulation of protein phosphorylation GO:0001933 4 0.044
regulation of synapse organization GO:0050807 3 0.044
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.043
Mouse Fly
alcohol biosynthetic process GO:0046165 2 0.043
cartilage condensation GO:0001502 3 0.043
negative regulation of cell development GO:0010721 26 0.043
Zebrafish Fly
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.043
neural tube development GO:0021915 62 0.043
collagen metabolic process GO:0032963 2 0.042
paraxial mesoderm development GO:0048339 8 0.042
multicellular organismal macromolecule metabolic process GO:0044259 2 0.042
activation of mapk activity GO:0000187 3 0.042
regulation of organ morphogenesis GO:2000027 35 0.042
Zebrafish Fly
cellular response to stress GO:0033554 62 0.042
positive regulation of epithelial cell differentiation GO:0030858 2 0.042
epithelial to mesenchymal transition GO:0001837 21 0.041
wound healing GO:0042060 90 0.041
negative regulation of wnt signaling pathway GO:0030178 30 0.041
regulation of response to external stimulus GO:0032101 31 0.040
cytosolic calcium ion transport GO:0060401 3 0.040
positive regulation of endothelial cell proliferation GO:0001938 1 0.040
muscle cell development GO:0055001 115 0.040
canonical wnt signaling pathway GO:0060070 48 0.040
endoderm formation GO:0001706 29 0.039
Zebrafish
developmental maturation GO:0021700 34 0.039
cellular biosynthetic process GO:0044249 286 0.039
Mouse Fly
extracellular matrix organization GO:0030198 27 0.039
epithelial cell morphogenesis GO:0003382 2 0.039
regulation of catenin import into nucleus GO:0035412 2 0.039
regulation of apoptotic process GO:0042981 98 0.039
Mouse
release of sequestered calcium ion into cytosol GO:0051209 3 0.039
cilium organization GO:0044782 71 0.038
optic nerve morphogenesis GO:0021631 6 0.037
regulation of chemotaxis GO:0050920 18 0.037
regulation of protein metabolic process GO:0051246 56 0.037
positive regulation of cell differentiation GO:0045597 30 0.037
Zebrafish Mouse
nuclear import GO:0051170 3 0.037
negative regulation of cell cycle GO:0045786 14 0.037
Human
response to acid chemical GO:0001101 17 0.036
axon regeneration GO:0031103 14 0.036
negative regulation of protein kinase activity GO:0006469 4 0.036
regulation of axonogenesis GO:0050770 32 0.036
ameboidal type cell migration GO:0001667 143 0.036
Fly
proepicardium development GO:0003342 4 0.036
positive regulation of apoptotic signaling pathway GO:2001235 1 0.036
rhombomere formation GO:0021594 12 0.036
Zebrafish
regulation of cardiac muscle tissue development GO:0055024 1 0.036
negative regulation of cell differentiation GO:0045596 46 0.036
Zebrafish Fly
regulation of protein localization to nucleus GO:1900180 2 0.035
negative regulation of axonogenesis GO:0050771 7 0.035
response to abiotic stimulus GO:0009628 122 0.035
negative regulation of neurogenesis GO:0050768 20 0.035
Zebrafish Fly
regulation of protein ubiquitination GO:0031396 3 0.035
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.035
regulation of cell matrix adhesion GO:0001952 1 0.035
regulation of protein kinase b signaling GO:0051896 8 0.035
vasculogenesis GO:0001570 41 0.034
negative regulation of gene expression GO:0010629 65 0.034
Mouse Fly
determination of bilateral symmetry GO:0009855 204 0.034
Zebrafish Mouse
mesoderm formation GO:0001707 43 0.034
Zebrafish
cellular response to lipid GO:0071396 39 0.034
negative regulation of developmental process GO:0051093 65 0.034
Zebrafish Fly
response to mechanical stimulus GO:0009612 24 0.034
regulation of phosphorus metabolic process GO:0051174 43 0.034
odontogenesis of dentin containing tooth GO:0042475 1 0.034

notch2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.405
Human
musculoskeletal system disease DOID:17 0 0.131
connective tissue disease DOID:65 0 0.131
bone development disease DOID:0080006 0 0.079
bone disease DOID:0080001 0 0.079
nervous system disease DOID:863 0 0.037
dysostosis DOID:1934 0 0.034