Danio rerio

8 known processes

npas2

neuronal PAS domain protein 2

(Aliases: zfCLOCK2)

npas2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic cyclic compound biosynthetic process GO:1901362 223 0.304
Zebrafish Fly
embryonic organ development GO:0048568 381 0.232
heterocycle metabolic process GO:0046483 290 0.202
Zebrafish Fly
chordate embryonic development GO:0043009 271 0.198
cellular nitrogen compound metabolic process GO:0034641 290 0.195
Zebrafish Fly
nitrogen compound metabolic process GO:0006807 319 0.184
Zebrafish Fly
signal transduction GO:0007165 455 0.167
embryonic organ morphogenesis GO:0048562 274 0.153
regulation of cellular metabolic process GO:0031323 320 0.152
Zebrafish Fly
circadian sleep wake cycle process GO:0022410 2 0.146
Fly
regulation of circadian sleep wake cycle GO:0042749 1 0.141
Fly
aging GO:0007568 2 0.140
striated muscle cell development GO:0055002 108 0.136
positive regulation of blood circulation GO:1903524 2 0.125
sleep GO:0030431 1 0.125
Fly
immune system process GO:0002376 241 0.124
single organism metabolic process GO:0044710 217 0.121
positive regulation of biological process GO:0048518 253 0.118
Zebrafish Fly
heterocycle biosynthetic process GO:0018130 215 0.110
Zebrafish Fly
immune system development GO:0002520 191 0.102
cellular macromolecule metabolic process GO:0044260 391 0.098
Zebrafish Fly
organic substance biosynthetic process GO:1901576 289 0.094
Zebrafish Fly
nucleobase containing compound metabolic process GO:0006139 274 0.094
Zebrafish Fly
regionalization GO:0003002 274 0.094
regulation of multicellular organismal process GO:0051239 277 0.093
Fly
sensory organ development GO:0007423 393 0.092
embryo development ending in birth or egg hatching GO:0009792 271 0.091
eye development GO:0001654 277 0.089
regulation of system process GO:0044057 40 0.088
system process GO:0003008 185 0.087
embryonic skeletal system development GO:0048706 97 0.085
hematopoietic or lymphoid organ development GO:0048534 191 0.084
skeletal system morphogenesis GO:0048705 102 0.078
biosynthetic process GO:0009058 294 0.076
Zebrafish Fly
regeneration GO:0031099 91 0.075
cellular biosynthetic process GO:0044249 286 0.073
Zebrafish Fly
nucleic acid metabolic process GO:0090304 244 0.073
Zebrafish Fly
regulation of systemic arterial blood pressure GO:0003073 1 0.072
transmembrane transport GO:0055085 120 0.068
regulation of blood circulation GO:1903522 32 0.066
blood circulation GO:0008015 87 0.066
specification of symmetry GO:0009799 204 0.065
inner ear development GO:0048839 126 0.064
regulation of transcription dna templated GO:0006355 213 0.064
Zebrafish Fly
negative regulation of cellular process GO:0048523 283 0.061
regulation of biosynthetic process GO:0009889 250 0.061
Zebrafish Fly
response to chemical GO:0042221 320 0.061
circadian sleep wake cycle GO:0042745 2 0.061
Fly
signal transduction in absence of ligand GO:0038034 1 0.060
hemopoiesis GO:0030097 183 0.060
regulation of response to stimulus GO:0048583 269 0.059
Fly
regulation of primary metabolic process GO:0080090 311 0.057
Zebrafish Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.057
Zebrafish Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.056
Zebrafish Fly
organic cyclic compound metabolic process GO:1901360 301 0.054
Zebrafish Fly
skeletal system development GO:0001501 181 0.053
muscle tissue development GO:0060537 110 0.053
maintenance of location GO:0051235 4 0.053
regulation of gene expression GO:0010468 265 0.053
Zebrafish Fly
heart contraction GO:0060047 71 0.052
hormone secretion GO:0046879 2 0.052
single organism biosynthetic process GO:0044711 71 0.052
growth GO:0040007 174 0.052
positive regulation of cellular component biogenesis GO:0044089 3 0.052
regulation of signaling GO:0023051 235 0.050
blood vessel development GO:0001568 246 0.050
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.050
Zebrafish Fly
negative regulation of adenylate cyclase activity GO:0007194 6 0.050
developmental growth GO:0048589 166 0.049
response to wounding GO:0009611 116 0.049
locomotion GO:0040011 313 0.048
sensory organ morphogenesis GO:0090596 200 0.048
response to nicotine GO:0035094 2 0.046
ear development GO:0043583 127 0.046
cell surface receptor signaling pathway GO:0007166 325 0.045
embryonic hemopoiesis GO:0035162 53 0.043
cellular aromatic compound metabolic process GO:0006725 295 0.042
Zebrafish Fly
cellular response to organic cyclic compound GO:0071407 38 0.042
g protein coupled receptor signaling pathway GO:0007186 74 0.041
regulation of behavior GO:0050795 24 0.041
Fly
myofibril assembly GO:0030239 48 0.040
cellular response to chemical stimulus GO:0070887 157 0.040
embryonic skeletal joint morphogenesis GO:0060272 3 0.040
cellular component morphogenesis GO:0032989 336 0.040
circulatory system process GO:0003013 87 0.040
regulation of blood pressure GO:0008217 1 0.040
muscle structure development GO:0061061 196 0.039
carbohydrate homeostasis GO:0033500 1 0.039
blood vessel morphogenesis GO:0048514 216 0.038
regulation of establishment of protein localization GO:0070201 4 0.038
neuron neuron synaptic transmission GO:0007270 1 0.037
segmentation GO:0035282 97 0.037
pigmentation GO:0043473 85 0.037
ion transmembrane transport GO:0034220 91 0.036
single organism localization GO:1902578 225 0.036
regulation of signal transduction GO:0009966 225 0.035
death GO:0016265 121 0.035
transcription from rna polymerase ii promoter GO:0006366 80 0.035
Fly
angiogenesis GO:0001525 158 0.035
regulation of metal ion transport GO:0010959 4 0.035
striated muscle cell differentiation GO:0051146 129 0.034
localization of cell GO:0051674 244 0.034
oocyte maturation GO:0001556 4 0.034
response to organic cyclic compound GO:0014070 51 0.034
metal ion transport GO:0030001 58 0.034
retina development in camera type eye GO:0060041 146 0.034
cell morphogenesis GO:0000902 289 0.033
skeletal muscle tissue development GO:0007519 67 0.033
rna biosynthetic process GO:0032774 181 0.033
Zebrafish Fly
cognition GO:0050890 1 0.033
cell death GO:0008219 121 0.033
central nervous system development GO:0007417 387 0.033
regulation of multicellular organism growth GO:0040014 4 0.033
chemotaxis GO:0006935 104 0.033
regulation of developmental process GO:0050793 247 0.033
cellular component movement GO:0006928 335 0.032
ubiquitin dependent protein catabolic process GO:0006511 3 0.032
muscle cell differentiation GO:0042692 139 0.032
fibril organization GO:0097435 1 0.032
ion transport GO:0006811 114 0.032
negative regulation of hormone secretion GO:0046888 2 0.031
negative regulation of biological process GO:0048519 304 0.031
regulation of ion transmembrane transport GO:0034765 18 0.031
regulation of cell communication GO:0010646 232 0.031
cellular response to lipid GO:0071396 39 0.031
homeostatic process GO:0042592 142 0.031
single organism transport GO:0044765 206 0.031
neurological system process GO:0050877 62 0.031
positive regulation of cellular metabolic process GO:0031325 94 0.030
Zebrafish Fly
hormone transport GO:0009914 2 0.030
regulation of transmembrane transporter activity GO:0022898 2 0.030
muscle cell development GO:0055001 115 0.029
aromatic compound biosynthetic process GO:0019438 217 0.029
Zebrafish Fly
cell projection organization GO:0030030 284 0.029
cell part morphogenesis GO:0032990 246 0.029
transcription dna templated GO:0006351 181 0.029
Zebrafish Fly
response to alkaloid GO:0043279 2 0.029
negative regulation of secretion GO:0051048 2 0.028
wound healing GO:0042060 90 0.028
negative regulation of secretion by cell GO:1903531 2 0.028
protein metabolic process GO:0019538 183 0.028
appendage development GO:0048736 80 0.028
response to food GO:0032094 1 0.027
cellular response to organic substance GO:0071310 105 0.027
regulation of cellular biosynthetic process GO:0031326 245 0.027
Zebrafish Fly
regulation of transmembrane transport GO:0034762 18 0.027
regulation of metabolic process GO:0019222 359 0.027
Zebrafish Fly
camera type eye development GO:0043010 222 0.027
embryonic skeletal system morphogenesis GO:0048704 93 0.027
cell cell recognition GO:0009988 1 0.027
amine metabolic process GO:0009308 2 0.026
negative regulation of programmed cell death GO:0043069 58 0.026
regulation of endodermal cell fate specification GO:0042663 15 0.026
regulation of ion transport GO:0043269 22 0.026
organonitrogen compound biosynthetic process GO:1901566 47 0.026
phagocytosis GO:0006909 3 0.026
positive regulation of protein complex assembly GO:0031334 2 0.026
neuron projection guidance GO:0097485 86 0.026
negative regulation of defense response GO:0031348 2 0.026
rna metabolic process GO:0016070 219 0.026
Zebrafish Fly
response to stress GO:0006950 263 0.026
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.025
Fly
adult behavior GO:0030534 2 0.025
regulation of ion transmembrane transporter activity GO:0032412 2 0.025
regulation of rna biosynthetic process GO:2001141 213 0.025
Zebrafish Fly
myotube cell development GO:0014904 35 0.025
response to organic substance GO:0010033 153 0.025
fin development GO:0033333 77 0.025
cell cell signaling GO:0007267 52 0.025
cell motility GO:0048870 244 0.025
cellular nitrogen compound biosynthetic process GO:0044271 218 0.025
Zebrafish Fly
response to light stimulus GO:0009416 46 0.025
negative regulation of blood circulation GO:1903523 2 0.024
gene expression GO:0010467 252 0.024
Zebrafish Fly
regulation of rna metabolic process GO:0051252 224 0.024
Zebrafish Fly
negative regulation of nucleotide metabolic process GO:0045980 7 0.024
skeletal muscle fiber development GO:0048741 35 0.024
glucose homeostasis GO:0042593 1 0.024
regulation of localization GO:0032879 104 0.024
defense response GO:0006952 47 0.023
multicellular organism growth GO:0035264 4 0.023
myotube differentiation GO:0014902 45 0.023
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.023
Zebrafish Fly
cellular response to radiation GO:0071478 4 0.023
response to hormone GO:0009725 48 0.023
negative regulation of multicellular organismal process GO:0051241 69 0.023
neuron projection development GO:0031175 180 0.023
macromolecule biosynthetic process GO:0009059 227 0.023
Zebrafish Fly
skeletal muscle organ development GO:0060538 78 0.023
larval development GO:0002164 2 0.023
tissue regeneration GO:0042246 74 0.023
determination of left right symmetry GO:0007368 179 0.023
regulation of anatomical structure morphogenesis GO:0022603 130 0.023
nucleobase containing small molecule metabolic process GO:0055086 32 0.023
regulation of macromolecule metabolic process GO:0060255 317 0.022
Zebrafish Fly
nucleic acid templated transcription GO:0097659 181 0.022
Zebrafish Fly
erythrocyte development GO:0048821 24 0.022
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.022
programmed cell death GO:0012501 119 0.022
positive regulation of muscle organ development GO:0048636 1 0.022
endocrine system development GO:0035270 65 0.022
regulation of heart contraction GO:0008016 32 0.022
response to endogenous stimulus GO:0009719 83 0.021
response to steroid hormone GO:0048545 35 0.021
heart process GO:0003015 71 0.021
fin regeneration GO:0031101 51 0.021
cellular component biogenesis GO:0044085 178 0.021
extrinsic apoptotic signaling pathway GO:0097191 3 0.021
regulation of cell differentiation GO:0045595 142 0.021
neuron projection morphogenesis GO:0048812 161 0.021
spemann organizer formation GO:0060061 10 0.020
cellular response to external stimulus GO:0071496 2 0.020
positive regulation of cellular process GO:0048522 201 0.020
Zebrafish Fly
regulation of tube size GO:0035150 2 0.020
myeloid cell differentiation GO:0030099 86 0.020
cell cycle g2 m phase transition GO:0044839 4 0.020
developmental cell growth GO:0048588 52 0.020
regulation of endodermal cell differentiation GO:1903224 15 0.019
leukocyte proliferation GO:0070661 1 0.019
cytokinesis GO:0000910 3 0.019
muscle fiber development GO:0048747 52 0.019
phosphorus metabolic process GO:0006793 109 0.019
morphogenesis of an epithelium GO:0002009 333 0.019
small molecule metabolic process GO:0044281 77 0.019
monovalent inorganic cation transport GO:0015672 42 0.019
organonitrogen compound metabolic process GO:1901564 74 0.019
regulation of transport GO:0051049 45 0.019
regulation of dna replication GO:0006275 3 0.019
cell projection morphogenesis GO:0048858 244 0.019
cellular component assembly GO:0022607 170 0.018
regulation of protein complex assembly GO:0043254 3 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.018
cartilage development GO:0051216 96 0.018
hypochord development GO:0055016 3 0.018
thrombocyte differentiation GO:0002574 4 0.018
neuron differentiation GO:0030182 353 0.018
vasculature development GO:0001944 278 0.018
regulation of cell growth GO:0001558 29 0.018
determination of bilateral symmetry GO:0009855 204 0.018
cardiac conduction system development GO:0003161 1 0.017
renal system development GO:0072001 94 0.017
regulation of apoptotic process GO:0042981 98 0.017
macromolecule modification GO:0043412 111 0.017
modification dependent macromolecule catabolic process GO:0043632 3 0.017
regulation of circadian rhythm GO:0042752 4 0.017
Fly
regulation of neurogenesis GO:0050767 87 0.017
fin morphogenesis GO:0033334 53 0.017
regulation of transporter activity GO:0032409 2 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
stem cell proliferation GO:0072089 4 0.017
gland development GO:0048732 143 0.017
regulation of skeletal muscle tissue development GO:0048641 4 0.017
kupffer s vesicle development GO:0070121 50 0.017
cellular response to estrogen stimulus GO:0071391 24 0.017
positive regulation of transport GO:0051050 2 0.016
urogenital system development GO:0001655 97 0.016
regulation of growth GO:0040008 42 0.016
regulation of protein catabolic process GO:0042176 1 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
regulation of cellular amine metabolic process GO:0033238 0 0.016
negative regulation of apoptotic process GO:0043066 55 0.016
heart development GO:0007507 313 0.016
mitochondrion organization GO:0007005 4 0.016
intracellular estrogen receptor signaling pathway GO:0030520 3 0.016
neuron development GO:0048666 262 0.016
cell morphogenesis involved in differentiation GO:0000904 195 0.016
regulation of cell size GO:0008361 29 0.016
embryonic heart tube development GO:0035050 133 0.015
positive regulation of catabolic process GO:0009896 4 0.015
actomyosin structure organization GO:0031032 53 0.015
circadian sleep wake cycle sleep GO:0050802 1 0.015
Fly
circadian regulation of gene expression GO:0032922 8 0.015
Zebrafish Fly
regulation of sequestering of calcium ion GO:0051282 4 0.015
single organism organelle organization GO:1902589 199 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
response to uv GO:0009411 3 0.015
regulation of cell development GO:0060284 100 0.015
striated muscle tissue development GO:0014706 110 0.015
actin filament based process GO:0030029 64 0.015
regulation of cell aging GO:0090342 1 0.014
negative regulation of innate immune response GO:0045824 2 0.014
negative regulation of cell death GO:0060548 60 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
Zebrafish Fly
generation of neurons GO:0048699 385 0.014
single organism behavior GO:0044708 24 0.014
Fly
head development GO:0060322 303 0.014
establishment of localization GO:0051234 244 0.014
regulation of reproductive process GO:2000241 4 0.014
regulation of dna metabolic process GO:0051052 11 0.014
developmental maturation GO:0021700 34 0.014
regulation of phosphorus metabolic process GO:0051174 43 0.014
cellular response to hormone stimulus GO:0032870 39 0.014
negative regulation of lyase activity GO:0051350 6 0.014
regulation of multicellular organismal metabolic process GO:0044246 2 0.014
muscle organ development GO:0007517 101 0.014
embryonic skeletal joint development GO:0072498 3 0.014
regulation of cell morphogenesis GO:0022604 42 0.014
homeostasis of number of cells GO:0048872 62 0.014
lymphocyte proliferation GO:0046651 1 0.014
response to radiation GO:0009314 51 0.014
negative regulation of cyclase activity GO:0031280 6 0.014
regulation of cyclic nucleotide metabolic process GO:0030799 15 0.013
metal ion homeostasis GO:0055065 26 0.013
cation transmembrane transport GO:0098655 65 0.013
organelle organization GO:0006996 227 0.013
calcium ion transport into cytosol GO:0060402 3 0.013
response to topologically incorrect protein GO:0035966 2 0.013
behavioral response to nicotine GO:0035095 2 0.013
cellular response to light stimulus GO:0071482 4 0.013
organism emergence from protective structure GO:0071684 4 0.013
cardiocyte differentiation GO:0035051 44 0.013
nucleobase containing compound biosynthetic process GO:0034654 205 0.013
Zebrafish Fly
behavior GO:0007610 74 0.013
Fly
camera type eye morphogenesis GO:0048593 108 0.013
response to lipid GO:0033993 60 0.013
regulation of extent of cell growth GO:0061387 29 0.013
ovulation cycle process GO:0022602 2 0.013
regulation of mechanoreceptor differentiation GO:0045631 1 0.013
peptide transport GO:0015833 1 0.013
peptidyl lysine acetylation GO:0018394 2 0.013
cellular response to steroid hormone stimulus GO:0071383 31 0.013
positive regulation of map kinase activity GO:0043406 3 0.013
positive regulation of macromolecule metabolic process GO:0010604 93 0.013
Zebrafish Fly
intracellular signal transduction GO:0035556 85 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
cellular response to unfolded protein GO:0034620 2 0.012
regulation of inflammatory response GO:0050727 2 0.012
cellular amine metabolic process GO:0044106 2 0.012
negative regulation of immune response GO:0050777 2 0.012
regulation of catalytic activity GO:0050790 55 0.012
stem cell division GO:0017145 1 0.012
regulation of sodium ion transport GO:0002028 2 0.012
regulation of phosphate metabolic process GO:0019220 43 0.012
cyclic purine nucleotide metabolic process GO:0052652 18 0.012
cyclic nucleotide biosynthetic process GO:0009190 18 0.012
spliceosomal snrnp assembly GO:0000387 2 0.012
bmp signaling pathway GO:0030509 52 0.012
pharyngeal muscle development GO:0043282 4 0.012
lipid storage GO:0019915 1 0.012
negative regulation of camp metabolic process GO:0030815 7 0.012
response to abiotic stimulus GO:0009628 122 0.012
activation of mapk activity GO:0000187 3 0.012
regulation of molecular function GO:0065009 70 0.012
nerve development GO:0021675 45 0.012
internal protein amino acid acetylation GO:0006475 2 0.012
cellular response to endogenous stimulus GO:0071495 68 0.012
protein acetylation GO:0006473 2 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
digestive system development GO:0055123 289 0.012
eye morphogenesis GO:0048592 144 0.012
regulation of purine nucleotide metabolic process GO:1900542 17 0.011
exocytosis GO:0006887 1 0.011
regulation of cell death GO:0010941 103 0.011
circadian behavior GO:0048512 5 0.011
Fly
multicellular organismal homeostasis GO:0048871 29 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.011
negative regulation of protein transport GO:0051224 3 0.011
response to unfolded protein GO:0006986 2 0.011
negative regulation of cyclic nucleotide metabolic process GO:0030800 7 0.011
appendage morphogenesis GO:0035107 56 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
Zebrafish Fly
regulation of cytokine production GO:0001817 3 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
b cell activation GO:0042113 2 0.011
mesoderm development GO:0007498 88 0.011
organophosphate metabolic process GO:0019637 37 0.011
mononuclear cell proliferation GO:0032943 1 0.011
positive regulation of signaling GO:0023056 56 0.011
cation transport GO:0006812 81 0.011
cytoskeleton organization GO:0007010 96 0.011
ovulation cycle GO:0042698 2 0.011
regulation of nucleic acid templated transcription GO:1903506 213 0.011
Zebrafish Fly
microtubule polymerization or depolymerization GO:0031109 3 0.011
negative regulation of multi organism process GO:0043901 3 0.011
ion homeostasis GO:0050801 41 0.011
dna modification GO:0006304 8 0.011
apoptotic process GO:0006915 116 0.011
regulation of neuron differentiation GO:0045664 56 0.011
regulation of anterior head development GO:2000742 2 0.010
somitogenesis GO:0001756 87 0.010
axonogenesis GO:0007409 152 0.010
positive regulation of developmental process GO:0051094 50 0.010
nucleoside phosphate metabolic process GO:0006753 28 0.010
negative regulation of metabolic process GO:0009892 86 0.010
positive regulation of dna metabolic process GO:0051054 1 0.010
protein acylation GO:0043543 3 0.010
inorganic ion transmembrane transport GO:0098660 57 0.010
nephron epithelium morphogenesis GO:0072088 1 0.010
energy reserve metabolic process GO:0006112 2 0.010
neuron death GO:0070997 21 0.010
regulation of cellular component organization GO:0051128 86 0.010
liver development GO:0001889 96 0.010
oxoacid metabolic process GO:0043436 31 0.010
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.010

npas2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.201
eye and adnexa disease DOID:1492 0 0.030
nervous system disease DOID:863 0 0.030
eye disease DOID:5614 0 0.030
sensory system disease DOID:0050155 0 0.030
connective tissue disease DOID:65 0 0.022
musculoskeletal system disease DOID:17 0 0.022
bone disease DOID:0080001 0 0.022
bone development disease DOID:0080006 0 0.022
osteochondrodysplasia DOID:2256 0 0.021
disease of metabolism DOID:0014667 0 0.011