Danio rerio

47 known processes

npc1

Niemann-Pick disease, type C1

(Aliases: im:7149020,wu:fb53a12,wu:fc29a12)

npc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
lipid storage GO:0019915 1 0.458
cellular protein catabolic process GO:0044257 4 0.402
maintenance of location GO:0051235 4 0.399
regulation of metabolic process GO:0019222 359 0.351
hemopoiesis GO:0030097 183 0.348
chordate embryonic development GO:0043009 271 0.327
ion transport GO:0006811 114 0.308
synaptic growth at neuromuscular junction GO:0051124 2 0.282
cell morphogenesis GO:0000902 289 0.257
detection of abiotic stimulus GO:0009582 24 0.252
regulation of synapse organization GO:0050807 3 0.252
cellular response to nutrient levels GO:0031669 2 0.245
cellular response to starvation GO:0009267 1 0.229
regulation of synapse assembly GO:0051963 3 0.217
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.215
larval development GO:0002164 2 0.202
cellular lipid metabolic process GO:0044255 36 0.198
macromolecule biosynthetic process GO:0009059 227 0.198
response to stress GO:0006950 263 0.189
inorganic ion transmembrane transport GO:0098660 57 0.187
autophagy GO:0006914 4 0.186
regulation of biological quality GO:0065008 263 0.170
generation of neurons GO:0048699 385 0.167
response to abiotic stimulus GO:0009628 122 0.166
response to external stimulus GO:0009605 264 0.147
multicellular organism growth GO:0035264 4 0.146
cellular response to extracellular stimulus GO:0031668 2 0.144
neuron differentiation GO:0030182 353 0.144
regulation of developmental process GO:0050793 247 0.142
cell projection morphogenesis GO:0048858 244 0.142
regulation of signal transduction GO:0009966 225 0.140
regulation of cell communication GO:0010646 232 0.139
myeloid cell differentiation GO:0030099 86 0.138
macroautophagy GO:0016236 1 0.138
cell projection organization GO:0030030 284 0.137
signal transduction GO:0007165 455 0.137
regulation of signaling GO:0023051 235 0.131
cellular response to external stimulus GO:0071496 2 0.129
neuron projection morphogenesis GO:0048812 161 0.129
regionalization GO:0003002 274 0.127
regulation of anatomical structure morphogenesis GO:0022603 130 0.126
regulation of multicellular organism growth GO:0040014 4 0.124
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.123
single organism metabolic process GO:0044710 217 0.120
blood vessel development GO:0001568 246 0.120
regulation of response to stimulus GO:0048583 269 0.118
skeletal system morphogenesis GO:0048705 102 0.117
positive regulation of biological process GO:0048518 253 0.114
response to other organism GO:0051707 97 0.114
sensory perception of chemical stimulus GO:0007606 3 0.113
developmental growth GO:0048589 166 0.113
vasculature development GO:0001944 278 0.112
regulation of autophagy GO:0010506 3 0.110
gene expression GO:0010467 252 0.109
transport GO:0006810 220 0.109
determination of left right symmetry GO:0007368 179 0.108
organic substance biosynthetic process GO:1901576 289 0.106
urogenital system development GO:0001655 97 0.095
apoptotic process GO:0006915 116 0.093
synapse assembly GO:0007416 9 0.093
regulation of protein catabolic process GO:0042176 1 0.092
regulation of macromolecule metabolic process GO:0060255 317 0.091
positive regulation of cellular process GO:0048522 201 0.090
p38mapk cascade GO:0038066 1 0.087
tube morphogenesis GO:0035239 349 0.086
central nervous system development GO:0007417 387 0.085
system process GO:0003008 185 0.084
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.079
negative regulation of biological process GO:0048519 304 0.079
cell part morphogenesis GO:0032990 246 0.077
neuron projection development GO:0031175 180 0.077
cellular component assembly GO:0022607 170 0.076
establishment of localization GO:0051234 244 0.076
oxoacid metabolic process GO:0043436 31 0.075
proteasomal protein catabolic process GO:0010498 2 0.075
cellular component morphogenesis GO:0032989 336 0.075
defense response to gram negative bacterium GO:0050829 8 0.074
intracellular signal transduction GO:0035556 85 0.074
growth GO:0040007 174 0.072
regulation of primary metabolic process GO:0080090 311 0.071
response to carbohydrate GO:0009743 3 0.071
positive regulation of cellular catabolic process GO:0031331 3 0.070
cognition GO:0050890 1 0.070
positive regulation of cell cycle GO:0045787 3 0.069
negative regulation of cellular process GO:0048523 283 0.065
modification dependent macromolecule catabolic process GO:0043632 3 0.065
reciprocal meiotic recombination GO:0007131 1 0.065
aging GO:0007568 2 0.063
organic cyclic compound metabolic process GO:1901360 301 0.062
regulation of cellular component organization GO:0051128 86 0.062
regulation of multicellular organismal development GO:2000026 223 0.062
response to copper ion GO:0046688 13 0.061
biosynthetic process GO:0009058 294 0.061
cellular macromolecule biosynthetic process GO:0034645 224 0.060
embryonic organ morphogenesis GO:0048562 274 0.060
protein modification process GO:0036211 100 0.060
phosphorylation GO:0016310 69 0.059
ras protein signal transduction GO:0007265 7 0.059
angiogenesis GO:0001525 158 0.059
regulation of multicellular organismal process GO:0051239 277 0.059
cell death GO:0008219 121 0.059
organic substance transport GO:0071702 58 0.058
adult behavior GO:0030534 2 0.058
neuron development GO:0048666 262 0.056
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.056
cellular protein modification process GO:0006464 100 0.056
negative regulation of protein phosphorylation GO:0001933 4 0.055
macromolecule localization GO:0033036 54 0.054
cellular response to stress GO:0033554 62 0.054
cellular macromolecule metabolic process GO:0044260 391 0.053
carbohydrate derivative biosynthetic process GO:1901137 43 0.053
regulation of biosynthetic process GO:0009889 250 0.052
negative regulation of protein kinase activity GO:0006469 4 0.052
phototransduction visible light GO:0007603 2 0.052
nuclear import GO:0051170 3 0.051
multi organism process GO:0051704 134 0.050
regulation of protein targeting GO:1903533 2 0.050
inorganic cation transmembrane transport GO:0098662 50 0.050
blood vessel morphogenesis GO:0048514 216 0.050
protein localization to nucleus GO:0034504 3 0.049
response to external biotic stimulus GO:0043207 97 0.049
locomotion GO:0040011 313 0.049
macromolecule modification GO:0043412 111 0.049
multicellular organismal reproductive process GO:0048609 35 0.048
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.047
protein metabolic process GO:0019538 183 0.047
nuclear transport GO:0051169 4 0.047
regulation of cell shape GO:0008360 1 0.047
cellular nitrogen compound biosynthetic process GO:0044271 218 0.047
i kappab kinase nf kappab signaling GO:0007249 4 0.047
synaptic transmission cholinergic GO:0007271 4 0.047
head development GO:0060322 303 0.047
regulation of nervous system development GO:0051960 90 0.046
embryonic skeletal system development GO:0048706 97 0.046
g protein coupled receptor signaling pathway GO:0007186 74 0.045
single organism organelle organization GO:1902589 199 0.045
cell morphogenesis involved in differentiation GO:0000904 195 0.045
axon development GO:0061564 166 0.045
cell growth GO:0016049 57 0.043
renal system development GO:0072001 94 0.043
regulation of cellular biosynthetic process GO:0031326 245 0.043
establishment of protein localization to organelle GO:0072594 4 0.042
regulation of protein import into nucleus GO:0042306 2 0.042
ubiquitin dependent protein catabolic process GO:0006511 3 0.042
wnt signaling pathway GO:0016055 80 0.042
cation transmembrane transport GO:0098655 65 0.041
metal ion transport GO:0030001 58 0.040
embryonic limb morphogenesis GO:0030326 2 0.040
positive regulation of cellular component biogenesis GO:0044089 3 0.040
carboxylic acid metabolic process GO:0019752 22 0.040
rna metabolic process GO:0016070 219 0.040
negative regulation of epithelial cell proliferation GO:0050680 1 0.040
regulation of growth GO:0040008 42 0.040
cell activation GO:0001775 16 0.039
phosphate containing compound metabolic process GO:0006796 108 0.039
negative regulation of sequestering of calcium ion GO:0051283 4 0.039
embryonic cranial skeleton morphogenesis GO:0048701 90 0.039
positive regulation of metabolic process GO:0009893 108 0.039
digestive tract development GO:0048565 265 0.039
neuron neuron synaptic transmission GO:0007270 1 0.039
response to inorganic substance GO:0010035 38 0.039
regulation of organ growth GO:0046620 3 0.038
nucleic acid metabolic process GO:0090304 244 0.038
digestive system development GO:0055123 289 0.038
response to oxygen levels GO:0070482 25 0.038
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.038
regulation of response to extracellular stimulus GO:0032104 1 0.037
embryonic skeletal system morphogenesis GO:0048704 93 0.037
response to biotic stimulus GO:0009607 97 0.036
tissue remodeling GO:0048771 4 0.036
response to corticosteroid GO:0031960 1 0.036
small molecule metabolic process GO:0044281 77 0.036
programmed cell death GO:0012501 119 0.036
regulation of phosphate metabolic process GO:0019220 43 0.036
meiotic nuclear division GO:0007126 4 0.036
camera type eye development GO:0043010 222 0.035
detection of external stimulus GO:0009581 24 0.035
meiotic cell cycle process GO:1903046 3 0.035
regulation of p38mapk cascade GO:1900744 1 0.035
organic acid metabolic process GO:0006082 31 0.035
phosphorus metabolic process GO:0006793 109 0.034
positive regulation of catabolic process GO:0009896 4 0.034
regulation of tube size GO:0035150 2 0.034
epithelial tube morphogenesis GO:0060562 148 0.033
regulation of intracellular protein transport GO:0033157 3 0.033
immune system development GO:0002520 191 0.033
reproductive process GO:0022414 40 0.033
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.032
glycoprotein metabolic process GO:0009100 23 0.032
embryo development ending in birth or egg hatching GO:0009792 271 0.032
positive regulation of apoptotic signaling pathway GO:2001235 1 0.032
regulation of protein localization to nucleus GO:1900180 2 0.031
regulation of establishment of protein localization GO:0070201 4 0.031
response to decreased oxygen levels GO:0036293 25 0.031
fatty acid transport GO:0015908 1 0.031
homeostatic process GO:0042592 142 0.030
epiboly GO:0090504 41 0.030
kidney development GO:0001822 92 0.030
positive regulation of transport GO:0051050 2 0.030
regulation of response to nutrient levels GO:0032107 1 0.029
regulation of receptor recycling GO:0001919 3 0.029
cellular catabolic process GO:0044248 27 0.029
regulation of cell differentiation GO:0045595 142 0.029
positive regulation of response to stimulus GO:0048584 80 0.029
negative regulation of protein localization to nucleus GO:1900181 2 0.029
mesenchyme development GO:0060485 127 0.029
regulation of dendrite morphogenesis GO:0048814 3 0.029
cellular component movement GO:0006928 335 0.029
regulation of cytoplasmic transport GO:1903649 4 0.028
eye development GO:0001654 277 0.028
response to transition metal nanoparticle GO:1990267 28 0.028
sequestering of calcium ion GO:0051208 3 0.028
gastrulation GO:0007369 208 0.028
positive regulation of striated muscle cell differentiation GO:0051155 1 0.028
regulation of developmental growth GO:0048638 38 0.028
nucleocytoplasmic transport GO:0006913 4 0.028
heterocycle biosynthetic process GO:0018130 215 0.027
regulation of cellular protein catabolic process GO:1903362 1 0.027
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.027
sensory perception GO:0007600 39 0.027
regulation of cellular metabolic process GO:0031323 320 0.027
heart morphogenesis GO:0003007 156 0.027
regulation of neurogenesis GO:0050767 87 0.027
gland development GO:0048732 143 0.027
compound eye development GO:0048749 2 0.027
dorsal ventral neural tube patterning GO:0021904 1 0.026
nitrogen compound metabolic process GO:0006807 319 0.026
cellular response to decreased oxygen levels GO:0036294 1 0.026
cell surface receptor signaling pathway GO:0007166 325 0.026
sensory organ development GO:0007423 393 0.026
immune system process GO:0002376 241 0.026
response to glucocorticoid GO:0051384 1 0.026
positive regulation of protein complex assembly GO:0031334 2 0.026
cellular protein metabolic process GO:0044267 129 0.026
regulation of sequestering of calcium ion GO:0051282 4 0.026
cell cycle process GO:0022402 53 0.026
periodic partitioning GO:0007365 1 0.025
heart development GO:0007507 313 0.025
developmental process involved in reproduction GO:0003006 27 0.025
defense response to bacterium GO:0042742 22 0.025
actin filament based movement GO:0030048 1 0.025
negative regulation of catabolic process GO:0009895 3 0.025
regulation of photoreceptor cell differentiation GO:0046532 2 0.025
protein targeting to nucleus GO:0044744 3 0.025
sensory organ morphogenesis GO:0090596 200 0.025
digestive tract morphogenesis GO:0048546 231 0.024
lipid localization GO:0010876 11 0.024
response to organic substance GO:0010033 153 0.024
developmental growth involved in morphogenesis GO:0060560 86 0.024
regulation of response to stress GO:0080134 36 0.024
embryonic organ development GO:0048568 381 0.024
regulation of cell morphogenesis GO:0022604 42 0.024
establishment of epithelial cell polarity GO:0090162 2 0.023
negative regulation of autophagy GO:0010507 1 0.023
segment polarity determination GO:0007367 1 0.023
endothelial cell fate commitment GO:0060839 3 0.023
lysosomal transport GO:0007041 2 0.023
regulation of localization GO:0032879 104 0.023
regulation of gene expression GO:0010468 265 0.022
regulation of synaptic plasticity GO:0048167 1 0.022
positive regulation of signaling GO:0023056 56 0.022
somitogenesis GO:0001756 87 0.022
regulation of response to oxidative stress GO:1902882 2 0.022
somatic stem cell maintenance GO:0035019 1 0.022
single organism transport GO:0044765 206 0.022
modification dependent protein catabolic process GO:0019941 3 0.022
cellular biosynthetic process GO:0044249 286 0.022
response to hexose GO:0009746 3 0.022
negative regulation of protein transport GO:0051224 3 0.022
detection of stimulus GO:0051606 29 0.022
connective tissue development GO:0061448 99 0.022
single organism nuclear import GO:1902593 3 0.022
stem cell maintenance GO:0019827 4 0.022
phototransduction GO:0007602 2 0.022
regulation of rho protein signal transduction GO:0035023 2 0.022
cytoskeleton dependent cytokinesis GO:0061640 3 0.022
positive regulation of cellular amine metabolic process GO:0033240 0 0.022
nucleobase containing compound metabolic process GO:0006139 274 0.022
determination of bilateral symmetry GO:0009855 204 0.022
cellular response to light stimulus GO:0071482 4 0.021
response to monosaccharide GO:0034284 3 0.021
regulation of apoptotic process GO:0042981 98 0.021
exocytosis GO:0006887 1 0.021
aromatic compound biosynthetic process GO:0019438 217 0.021
organelle organization GO:0006996 227 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.021
neuron projection guidance GO:0097485 86 0.021
axonogenesis GO:0007409 152 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
response to glucose GO:0009749 3 0.020
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.020
protein import into nucleus GO:0006606 3 0.020
regulation of dendrite development GO:0050773 3 0.020
organelle fission GO:0048285 23 0.020
response to nutrient GO:0007584 3 0.020
positive regulation of cell communication GO:0010647 56 0.020
cell migration involved in gastrulation GO:0042074 79 0.020
single organism reproductive process GO:0044702 40 0.020
cellular response to hypoxia GO:0071456 1 0.020
positive regulation of signal transduction GO:0009967 56 0.020
somite specification GO:0001757 12 0.019
reproduction GO:0000003 40 0.019
regulation of cell projection organization GO:0031344 44 0.019
behavior GO:0007610 74 0.019
small gtpase mediated signal transduction GO:0007264 8 0.019
single organism biosynthetic process GO:0044711 71 0.019
centrosome cycle GO:0007098 1 0.019
extrinsic apoptotic signaling pathway GO:0097191 3 0.019
synapse organization GO:0050808 21 0.019
lipid metabolic process GO:0006629 52 0.019
cellular nitrogen compound metabolic process GO:0034641 290 0.019
negative regulation of cell death GO:0060548 60 0.019
regulation of protein transport GO:0051223 3 0.019
myeloid cell homeostasis GO:0002262 56 0.019
nucleic acid templated transcription GO:0097659 181 0.019
regulation of cytokine production GO:0001817 3 0.019
rna biosynthetic process GO:0032774 181 0.019
female gamete generation GO:0007292 14 0.019
regulation of heart growth GO:0060420 2 0.019
cation transport GO:0006812 81 0.018
death GO:0016265 121 0.018
regulation of epithelial cell proliferation GO:0050678 3 0.018
transition metal ion transport GO:0000041 6 0.018
single organism behavior GO:0044708 24 0.018
regulation of protein ubiquitination GO:0031396 3 0.018
response to nutrient levels GO:0031667 10 0.018
regulation of nucleotide catabolic process GO:0030811 2 0.018
organic cyclic compound biosynthetic process GO:1901362 223 0.018
long chain fatty acid transport GO:0015909 1 0.018
response to drug GO:0042493 3 0.018
cellular response to drug GO:0035690 1 0.018
wound healing GO:0042060 90 0.018
regulation of cell size GO:0008361 29 0.018
sexual reproduction GO:0019953 36 0.018
specification of axis polarity GO:0065001 4 0.018
cellular ketone metabolic process GO:0042180 11 0.018
post embryonic morphogenesis GO:0009886 4 0.018
epithelial cell differentiation GO:0030855 116 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
cellular aldehyde metabolic process GO:0006081 4 0.018
protein import GO:0017038 3 0.017
regulation of blood vessel size GO:0050880 2 0.017
regulation of reactive oxygen species metabolic process GO:2000377 2 0.017
regulation of transcription dna templated GO:0006355 213 0.017
response to antibiotic GO:0046677 1 0.017
neuronal action potential GO:0019228 18 0.017
cellular response to oxygen levels GO:0071453 1 0.017
regulation of gtpase activity GO:0043087 2 0.017
neural tube patterning GO:0021532 33 0.017
cellular response to radiation GO:0071478 4 0.017
cellular macromolecule catabolic process GO:0044265 12 0.017
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.017
protein complex biogenesis GO:0070271 30 0.017
negative regulation of programmed cell death GO:0043069 58 0.016
appendage development GO:0048736 80 0.016
regulation of cardiac muscle tissue development GO:0055024 1 0.016
regulation of neuron differentiation GO:0045664 56 0.016
negative regulation of developmental growth GO:0048640 9 0.016
myeloid cell development GO:0061515 32 0.016
positive regulation of defense response to virus by host GO:0002230 0 0.016
chemical homeostasis GO:0048878 49 0.016
response to starvation GO:0042594 5 0.016
cellular component disassembly GO:0022411 1 0.016
positive regulation of blood circulation GO:1903524 2 0.016
regulation of establishment of planar polarity GO:0090175 4 0.016
pancreas development GO:0031016 84 0.016
notch signaling pathway GO:0007219 35 0.016
cardiac cell fate commitment GO:0060911 1 0.016
fat soluble vitamin metabolic process GO:0006775 4 0.016
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.016
regulation of embryonic development GO:0045995 47 0.015
multicellular organism reproduction GO:0032504 35 0.015
negative regulation of kinase activity GO:0033673 4 0.015
stem cell division GO:0017145 1 0.015
positive regulation of myeloid cell differentiation GO:0045639 2 0.015
cation homeostasis GO:0055080 33 0.015
zymogen activation GO:0031638 3 0.015
regulation of gtp catabolic process GO:0033124 2 0.015
peptidyl serine modification GO:0018209 2 0.015
anterior posterior pattern specification GO:0009952 152 0.015
b cell differentiation GO:0030183 1 0.015
macromolecular complex assembly GO:0065003 35 0.015
cellular aromatic compound metabolic process GO:0006725 295 0.015
developmental cell growth GO:0048588 52 0.015
sequestering of metal ion GO:0051238 3 0.015
rho protein signal transduction GO:0007266 5 0.015
cellular amine metabolic process GO:0044106 2 0.015
regulation of catalytic activity GO:0050790 55 0.015
regulation of skeletal muscle fiber development GO:0048742 2 0.015
fat soluble vitamin biosynthetic process GO:0042362 2 0.015
tube closure GO:0060606 1 0.015
post embryonic organ development GO:0048569 4 0.015
response to chemical GO:0042221 320 0.014
segmentation GO:0035282 97 0.014
apoptotic process involved in development GO:1902742 2 0.014
negative regulation of metabolic process GO:0009892 86 0.014
meiotic chromosome segregation GO:0045132 3 0.014
positive regulation of cell division GO:0051781 2 0.014
amine metabolic process GO:0009308 2 0.014
regulation of reproductive process GO:2000241 4 0.014
neurological system process GO:0050877 62 0.014
homeostasis of number of cells within a tissue GO:0048873 4 0.014
negative regulation of apoptotic process GO:0043066 55 0.014
cytokinesis GO:0000910 3 0.014
gamete generation GO:0007276 33 0.014
somite development GO:0061053 96 0.014
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.014
cell aging GO:0007569 2 0.014
regulation of metal ion transport GO:0010959 4 0.014
positive regulation of cellular metabolic process GO:0031325 94 0.014
receptor recycling GO:0001881 4 0.014
adherens junction organization GO:0034332 4 0.013
taxis GO:0042330 109 0.013
interaction with host GO:0051701 4 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
neuroblast proliferation GO:0007405 2 0.013
detection of temperature stimulus GO:0016048 0 0.013
negative regulation of intracellular protein transport GO:0090317 3 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.013
regulation of nitrogen compound metabolic process GO:0051171 251 0.013
response to bacterium GO:0009617 58 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
guanosine containing compound metabolic process GO:1901068 4 0.013
embryonic heart tube development GO:0035050 133 0.013
embryonic viscerocranium morphogenesis GO:0048703 52 0.013
stem cell proliferation GO:0072089 4 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
negative regulation of molecular function GO:0044092 23 0.013
cell death in response to oxidative stress GO:0036473 2 0.013
cell cycle GO:0007049 93 0.013
pronephros development GO:0048793 69 0.013
proximal distal pattern formation GO:0009954 1 0.013
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.013
epithelial cell development GO:0002064 42 0.013
regulation of receptor activity GO:0010469 2 0.013
transcription dna templated GO:0006351 181 0.012
regulation of rna metabolic process GO:0051252 224 0.012
response to extracellular stimulus GO:0009991 10 0.012
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.012
sensory perception of light stimulus GO:0050953 19 0.012
regulation of protein metabolic process GO:0051246 56 0.012
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.012
primary neural tube formation GO:0014020 1 0.012
morphogenesis of an epithelial fold GO:0060571 1 0.012
ion homeostasis GO:0050801 41 0.012
regulation of rna biosynthetic process GO:2001141 213 0.012
cytokinetic process GO:0032506 2 0.012
regulation of hormone secretion GO:0046883 2 0.012
cellular response to toxic substance GO:0097237 1 0.012
single organism intracellular transport GO:1902582 25 0.012
regulation of oxidative stress induced cell death GO:1903201 2 0.012
regulation of cellular ketone metabolic process GO:0010565 7 0.012
localization of cell GO:0051674 244 0.012
axis elongation GO:0003401 31 0.012
regulation of wnt signaling pathway GO:0030111 53 0.012
regulation of molecular function GO:0065009 70 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
actin mediated cell contraction GO:0070252 1 0.012
synaptic transmission GO:0007268 35 0.012
water homeostasis GO:0030104 4 0.012
beta amyloid metabolic process GO:0050435 1 0.012
sulfur compound biosynthetic process GO:0044272 9 0.012
transmembrane transport GO:0055085 120 0.012

npc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.141
nervous system disease DOID:863 0 0.055
muscle tissue disease DOID:66 0 0.051
musculoskeletal system disease DOID:17 0 0.051
muscular disease DOID:0080000 0 0.051
myopathy DOID:423 0 0.051
endocrine gland cancer DOID:170 0 0.042
organ system cancer DOID:0050686 0 0.042
disease of cellular proliferation DOID:14566 0 0.042
cancer DOID:162 0 0.042
cardiovascular system disease DOID:1287 0 0.032
cardiomyopathy DOID:0050700 0 0.031
intrinsic cardiomyopathy DOID:0060036 0 0.031
heart disease DOID:114 0 0.031
immune system disease DOID:2914 0 0.027
integumentary system disease DOID:16 0 0.023
brain disease DOID:936 0 0.023
central nervous system disease DOID:331 0 0.023
disease of metabolism DOID:0014667 0 0.019
inherited metabolic disorder DOID:655 0 0.019
thoracic cancer DOID:5093 0 0.018
large intestine cancer DOID:5672 0 0.018
intestinal cancer DOID:10155 0 0.018
gastrointestinal system cancer DOID:3119 0 0.018
lysosomal storage disease DOID:3211 0 0.016
breast cancer DOID:1612 0 0.014
hematopoietic system disease DOID:74 0 0.013
colon cancer DOID:219 0 0.013
colorectal cancer DOID:9256 0 0.013
colon carcinoma DOID:1520 0 0.013
disease of mental health DOID:150 0 0.013
tauopathy DOID:680 0 0.012
neurodegenerative disease DOID:1289 0 0.012