Danio rerio

0 known processes

npc2

Niemann-Pick disease, type C2

(Aliases: sb:cb292,cb292)

npc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.290
autophagy GO:0006914 4 0.172
developmental growth GO:0048589 166 0.168
protein stabilization GO:0050821 2 0.135
cellular protein catabolic process GO:0044257 4 0.135
cell surface receptor signaling pathway GO:0007166 325 0.108
embryo development ending in birth or egg hatching GO:0009792 271 0.101
regulation of metabolic process GO:0019222 359 0.087
programmed cell death GO:0012501 119 0.087
regulation of cell death GO:0010941 103 0.086
regulation of gene expression GO:0010468 265 0.081
regulation of blood pressure GO:0008217 1 0.080
endosomal transport GO:0016197 2 0.079
death GO:0016265 121 0.075
immune system process GO:0002376 241 0.070
multicellular organismal macromolecule metabolic process GO:0044259 2 0.069
response to hexose GO:0009746 3 0.065
response to glucose GO:0009749 3 0.065
response to stress GO:0006950 263 0.061
positive regulation of transport GO:0051050 2 0.059
cellular response to starvation GO:0009267 1 0.059
glial cell migration GO:0008347 3 0.059
morphogenesis of an epithelium GO:0002009 333 0.058
gene expression GO:0010467 252 0.056
adult behavior GO:0030534 2 0.054
negative regulation of biological process GO:0048519 304 0.053
cell death GO:0008219 121 0.053
collagen metabolic process GO:0032963 2 0.050
establishment of localization GO:0051234 244 0.049
organic substance biosynthetic process GO:1901576 289 0.048
aging GO:0007568 2 0.047
regulation of synapse assembly GO:0051963 3 0.047
response to external stimulus GO:0009605 264 0.047
regulation of cell communication GO:0010646 232 0.046
regulation of proteolysis GO:0030162 24 0.045
regulation of peptidase activity GO:0052547 23 0.044
multicellular organism growth GO:0035264 4 0.043
cellular response to extracellular stimulus GO:0031668 2 0.043
tube morphogenesis GO:0035239 349 0.042
embryonic cranial skeleton morphogenesis GO:0048701 90 0.041
response to carbohydrate GO:0009743 3 0.041
regulation of biological quality GO:0065008 263 0.040
response to monosaccharide GO:0034284 3 0.039
embryonic skeletal system morphogenesis GO:0048704 93 0.038
cellular macromolecule metabolic process GO:0044260 391 0.038
biosynthetic process GO:0009058 294 0.036
proteolysis GO:0006508 38 0.036
lipid storage GO:0019915 1 0.036
protein targeting to nucleus GO:0044744 3 0.036
establishment of protein localization to organelle GO:0072594 4 0.036
regulation of blood vessel size GO:0050880 2 0.036
cellular biosynthetic process GO:0044249 286 0.034
response to corticosteroid GO:0031960 1 0.034
synaptic vesicle endocytosis GO:0048488 1 0.034
locomotion GO:0040011 313 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.033
lytic vacuole organization GO:0080171 1 0.033
blood vessel development GO:0001568 246 0.032
negative regulation of catabolic process GO:0009895 3 0.032
hormone transport GO:0009914 2 0.032
negative regulation of cellular process GO:0048523 283 0.032
growth GO:0040007 174 0.032
synaptic growth at neuromuscular junction GO:0051124 2 0.031
sensory organ development GO:0007423 393 0.031
regulation of synapse organization GO:0050807 3 0.030
regulation of signal transduction GO:0009966 225 0.029
synaptic vesicle recycling GO:0036465 1 0.029
response to organic substance GO:0010033 153 0.028
protein localization to nucleus GO:0034504 3 0.028
regulation of apoptotic process GO:0042981 98 0.028
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.028
regulation of multicellular organism growth GO:0040014 4 0.028
maintenance of location GO:0051235 4 0.027
modification dependent protein catabolic process GO:0019941 3 0.027
regulation of multicellular organismal process GO:0051239 277 0.027
regulation of developmental process GO:0050793 247 0.026
organic substance transport GO:0071702 58 0.026
response to glucocorticoid GO:0051384 1 0.026
multi organism process GO:0051704 134 0.025
organonitrogen compound metabolic process GO:1901564 74 0.025
organelle fusion GO:0048284 3 0.025
embryonic viscerocranium morphogenesis GO:0048703 52 0.025
gtp catabolic process GO:0006184 2 0.025
cellular response to organic substance GO:0071310 105 0.024
cellular response to nutrient levels GO:0031669 2 0.024
regulation of endopeptidase activity GO:0052548 23 0.024
positive regulation of cellular catabolic process GO:0031331 3 0.023
cellular component assembly GO:0022607 170 0.023
nuclear transport GO:0051169 4 0.023
single organism transport GO:0044765 206 0.023
positive regulation of apoptotic signaling pathway GO:2001235 1 0.023
regulation of cellular metabolic process GO:0031323 320 0.023
positive regulation of biological process GO:0048518 253 0.023
signal transduction GO:0007165 455 0.022
protein import into nucleus GO:0006606 3 0.022
apoptotic process GO:0006915 116 0.022
regulation of cellular response to oxidative stress GO:1900407 2 0.022
organic cyclic compound biosynthetic process GO:1901362 223 0.021
organic cyclic compound metabolic process GO:1901360 301 0.021
hormone secretion GO:0046879 2 0.021
regulation of hormone secretion GO:0046883 2 0.021
blood vessel morphogenesis GO:0048514 216 0.021
nucleic acid transport GO:0050657 2 0.020
nitrogen compound metabolic process GO:0006807 319 0.020
regulation of multicellular organismal development GO:2000026 223 0.020
regulation of rna metabolic process GO:0051252 224 0.020
single organism nuclear import GO:1902593 3 0.020
cellular ketone metabolic process GO:0042180 11 0.020
central nervous system development GO:0007417 387 0.020
response to chemical GO:0042221 320 0.020
small molecule metabolic process GO:0044281 77 0.019
cellular response to chemical stimulus GO:0070887 157 0.019
regulation of cellular protein catabolic process GO:1903362 1 0.019
guanosine containing compound catabolic process GO:1901069 2 0.019
regulation of response to stimulus GO:0048583 269 0.019
cellular protein metabolic process GO:0044267 129 0.019
cellular response to unfolded protein GO:0034620 2 0.019
er nucleus signaling pathway GO:0006984 2 0.018
stem cell division GO:0017145 1 0.018
rna metabolic process GO:0016070 219 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
regulation of cell activation GO:0050865 1 0.018
guanosine containing compound metabolic process GO:1901068 4 0.018
response to topologically incorrect protein GO:0035966 2 0.018
g protein coupled receptor signaling pathway GO:0007186 74 0.018
single organism metabolic process GO:0044710 217 0.018
response to steroid hormone GO:0048545 35 0.018
multicellular organismal metabolic process GO:0044236 2 0.018
single organism localization GO:1902578 225 0.018
protein metabolic process GO:0019538 183 0.017
glucose homeostasis GO:0042593 1 0.017
response to amine GO:0014075 1 0.017
regulation of protein catabolic process GO:0042176 1 0.017
phagocytosis GO:0006909 3 0.017
protein import GO:0017038 3 0.017
chordate embryonic development GO:0043009 271 0.017
positive regulation of secretion by cell GO:1903532 1 0.017
macroautophagy GO:0016236 1 0.017
macromolecule biosynthetic process GO:0009059 227 0.017
nucleocytoplasmic transport GO:0006913 4 0.016
embryonic skeletal system development GO:0048706 97 0.016
cellular aldehyde metabolic process GO:0006081 4 0.016
positive regulation of blood circulation GO:1903524 2 0.016
regulation of cytokine production GO:0001817 3 0.016
negative regulation of cell death GO:0060548 60 0.016
hormone biosynthetic process GO:0042446 3 0.016
gtp metabolic process GO:0046039 4 0.016
regulation of macromolecule metabolic process GO:0060255 317 0.016
regulation of tube size GO:0035150 2 0.016
single organism biosynthetic process GO:0044711 71 0.016
ubiquitin dependent protein catabolic process GO:0006511 3 0.016
muscle organ development GO:0007517 101 0.016
positive regulation of catabolic process GO:0009896 4 0.016
regulation of protein targeting GO:1903533 2 0.016
negative regulation of autophagy GO:0010507 1 0.015
cellular response to reactive oxygen species GO:0034614 2 0.015
positive regulation of multicellular organismal process GO:0051240 52 0.015
rna biosynthetic process GO:0032774 181 0.015
regulation of protein transport GO:0051223 3 0.015
negative regulation of cellular catabolic process GO:0031330 3 0.015
tissue regeneration GO:0042246 74 0.015
interspecies interaction between organisms GO:0044419 4 0.015
skeletal system morphogenesis GO:0048705 102 0.015
response to hormone GO:0009725 48 0.015
stem cell proliferation GO:0072089 4 0.015
immune system development GO:0002520 191 0.014
cell death in response to oxidative stress GO:0036473 2 0.014
positive regulation of cellular process GO:0048522 201 0.014
rna localization GO:0006403 4 0.014
lysosomal transport GO:0007041 2 0.014
negative regulation of epithelial cell proliferation GO:0050680 1 0.014
cellular component movement GO:0006928 335 0.014
regulation of ph GO:0006885 3 0.014
cellular response to external stimulus GO:0071496 2 0.014
cellular amine metabolic process GO:0044106 2 0.014
stem cell maintenance GO:0019827 4 0.014
skeletal system development GO:0001501 181 0.014
nuclear import GO:0051170 3 0.014
regulation of protein import into nucleus GO:0042306 2 0.014
vasculature development GO:0001944 278 0.014
regulation of primary metabolic process GO:0080090 311 0.014
synaptic vesicle transport GO:0048489 1 0.014
regeneration GO:0031099 91 0.014
extrinsic apoptotic signaling pathway GO:0097191 3 0.014
negative regulation of cell communication GO:0010648 96 0.013
membrane fusion GO:0061025 2 0.013
epithelial cell differentiation GO:0030855 116 0.013
regulation of inflammatory response GO:0050727 2 0.013
angiogenesis GO:0001525 158 0.013
striated muscle tissue development GO:0014706 110 0.013
single organism organelle organization GO:1902589 199 0.013
cell migration involved in heart development GO:0060973 22 0.013
protein targeting to membrane GO:0006612 1 0.013
regulation of cellular component organization GO:0051128 86 0.013
response to ketone GO:1901654 1 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
calcium mediated signaling GO:0019722 2 0.013
regulation of autophagy GO:0010506 3 0.013
defense response to bacterium GO:0042742 22 0.013
axon ensheathment in central nervous system GO:0032291 2 0.013
positive regulation of secretion GO:0051047 1 0.013
muscle structure development GO:0061061 196 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
regulation of signaling GO:0023051 235 0.013
amine metabolic process GO:0009308 2 0.013
cellular response to molecule of bacterial origin GO:0071219 3 0.013
nitric oxide metabolic process GO:0046209 2 0.013
regulation of cytoplasmic transport GO:1903649 4 0.013
cellular response to hormone stimulus GO:0032870 39 0.013
lipoprotein metabolic process GO:0042157 4 0.013
mitochondrion organization GO:0007005 4 0.013
regulation of macromolecule biosynthetic process GO:0010556 225 0.013
endosome to lysosome transport GO:0008333 1 0.013
negative regulation of protein transport GO:0051224 3 0.012
lipid biosynthetic process GO:0008610 22 0.012
peptide transport GO:0015833 1 0.012
establishment of organelle localization GO:0051656 45 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
urogenital system development GO:0001655 97 0.012
meiotic nuclear division GO:0007126 4 0.012
regulation of organ growth GO:0046620 3 0.012
response to wounding GO:0009611 116 0.012
nucleobase containing compound metabolic process GO:0006139 274 0.012
compound eye development GO:0048749 2 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
regulation of nervous system development GO:0051960 90 0.012
regulation of cellular amine metabolic process GO:0033238 0 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.012
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.012
regulation of oligodendrocyte differentiation GO:0048713 1 0.012
antimicrobial humoral response GO:0019730 2 0.012
cellular response to steroid hormone stimulus GO:0071383 31 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.012
establishment of localization in cell GO:0051649 77 0.012
regulation of cell differentiation GO:0045595 142 0.012
behavior GO:0007610 74 0.012
nucleobase containing compound transport GO:0015931 2 0.012
establishment of rna localization GO:0051236 3 0.012
connective tissue development GO:0061448 99 0.012
head development GO:0060322 303 0.012
multi organism cellular process GO:0044764 2 0.012
organelle localization GO:0051640 49 0.012
morphogenesis of a branching epithelium GO:0061138 16 0.012
neuroblast proliferation GO:0007405 2 0.012
rna transport GO:0050658 2 0.012
tissue remodeling GO:0048771 4 0.012
negative regulation of signaling GO:0023057 96 0.012
positive regulation of apoptotic process GO:0043065 29 0.011
regulation of binding GO:0051098 3 0.011
negative regulation of cytoplasmic transport GO:1903650 2 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
organic acid metabolic process GO:0006082 31 0.011
regulation of cell shape GO:0008360 1 0.011
endoplasmic reticulum unfolded protein response GO:0030968 2 0.011
protein polyubiquitination GO:0000209 4 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
protein acylation GO:0043543 3 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
enzyme linked receptor protein signaling pathway GO:0007167 106 0.011
response to bacterium GO:0009617 58 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
interaction with host GO:0051701 4 0.011
regulation of gtpase activity GO:0043087 2 0.011
cellular response to estrogen stimulus GO:0071391 24 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
regulation of programmed cell death GO:0043067 101 0.011
establishment of synaptic vesicle localization GO:0097480 1 0.011
multicellular organismal response to stress GO:0033555 2 0.011
sensory perception of chemical stimulus GO:0007606 3 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
peptidyl serine modification GO:0018209 2 0.011
cellular amino acid biosynthetic process GO:0008652 2 0.011
innate immune response GO:0045087 13 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
bone remodeling GO:0046849 2 0.010
regulation of reproductive process GO:2000241 4 0.010
nuclear export GO:0051168 1 0.010
regulation of purine nucleotide catabolic process GO:0033121 2 0.010
transport GO:0006810 220 0.010
brain development GO:0007420 293 0.010
axonogenesis GO:0007409 152 0.010
golgi vesicle transport GO:0048193 3 0.010
wound healing GO:0042060 90 0.010
negative chemotaxis GO:0050919 1 0.010
neuron differentiation GO:0030182 353 0.010
vacuole organization GO:0007033 9 0.010
hemopoiesis GO:0030097 183 0.010
regionalization GO:0003002 274 0.010

npc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.217
nervous system disease DOID:863 0 0.067
disease of metabolism DOID:0014667 0 0.047
inherited metabolic disorder DOID:655 0 0.047
central nervous system disease DOID:331 0 0.020
brain disease DOID:936 0 0.020
lysosomal storage disease DOID:3211 0 0.011