Danio rerio

0 known processes

nploc4

nuclear protein localization 4 homolog (S. cerevisiae)

(Aliases: wu:fi11f09,zgc:55988,npl4)

nploc4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.346
Worm
ubiquitin dependent protein catabolic process GO:0006511 3 0.271
Worm
embryo development ending in birth or egg hatching GO:0009792 271 0.184
Worm
cellular protein catabolic process GO:0044257 4 0.136
Worm
regulation of metabolic process GO:0019222 359 0.135
regulation of gene expression GO:0010468 265 0.133
modification dependent macromolecule catabolic process GO:0043632 3 0.129
Worm
regulation of biological quality GO:0065008 263 0.124
regulation of circadian rhythm GO:0042752 4 0.119
nuclear transport GO:0051169 4 0.118
aging GO:0007568 2 0.108
Worm
regulation of protein catabolic process GO:0042176 1 0.102
regulation of cellular metabolic process GO:0031323 320 0.101
nucleobase containing compound metabolic process GO:0006139 274 0.098
cell death GO:0008219 121 0.095
larval development GO:0002164 2 0.095
Worm
cell part morphogenesis GO:0032990 246 0.092
negative regulation of biological process GO:0048519 304 0.086
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.084
cellular localization GO:0051641 97 0.081
nucleocytoplasmic transport GO:0006913 4 0.080
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.080
Worm
lipid storage GO:0019915 1 0.079
single organism transport GO:0044765 206 0.078
sensory organ development GO:0007423 393 0.075
modification dependent protein catabolic process GO:0019941 3 0.074
Worm
transport GO:0006810 220 0.072
Worm
cellular biosynthetic process GO:0044249 286 0.072
cellular component morphogenesis GO:0032989 336 0.067
regulation of macromolecule metabolic process GO:0060255 317 0.065
maintenance of location GO:0051235 4 0.063
regulation of establishment of protein localization GO:0070201 4 0.063
guanosine containing compound catabolic process GO:1901069 2 0.062
single organism localization GO:1902578 225 0.062
cellular catabolic process GO:0044248 27 0.062
Worm
lateral inhibition GO:0046331 1 0.060
single organism organelle organization GO:1902589 199 0.060
nucleobase containing compound biosynthetic process GO:0034654 205 0.059
positive regulation of catabolic process GO:0009896 4 0.057
regulation of mrna processing GO:0050684 3 0.057
macromolecule biosynthetic process GO:0009059 227 0.057
cellular nitrogen compound metabolic process GO:0034641 290 0.056
cellular macromolecule metabolic process GO:0044260 391 0.055
Worm
heterocycle metabolic process GO:0046483 290 0.055
positive regulation of cellular catabolic process GO:0031331 3 0.051
establishment of localization GO:0051234 244 0.050
Worm
regionalization GO:0003002 274 0.050
hormone transport GO:0009914 2 0.049
locomotor rhythm GO:0045475 3 0.049
signal transduction GO:0007165 455 0.048
cellular nitrogen compound biosynthetic process GO:0044271 218 0.048
gtp catabolic process GO:0006184 2 0.048
cellular response to nutrient levels GO:0031669 2 0.047
nucleic acid metabolic process GO:0090304 244 0.045
gtp metabolic process GO:0046039 4 0.045
nitrogen compound metabolic process GO:0006807 319 0.045
regulation of macromolecule biosynthetic process GO:0010556 225 0.044
cellular aromatic compound metabolic process GO:0006725 295 0.044
regulation of apoptotic process GO:0042981 98 0.043
regulation of localization GO:0032879 104 0.042
hormone secretion GO:0046879 2 0.042
regulation of signaling GO:0023051 235 0.042
regulation of signal transduction GO:0009966 225 0.042
regulation of cellular biosynthetic process GO:0031326 245 0.041
guanosine containing compound metabolic process GO:1901068 4 0.040
cellular response to extracellular stimulus GO:0031668 2 0.040
cell projection organization GO:0030030 284 0.040
regulation of nitrogen compound metabolic process GO:0051171 251 0.040
death GO:0016265 121 0.039
establishment of protein localization to organelle GO:0072594 4 0.039
neuron differentiation GO:0030182 353 0.038
rna biosynthetic process GO:0032774 181 0.038
locomotion GO:0040011 313 0.038
Worm
proteolysis GO:0006508 38 0.037
Worm
rna metabolic process GO:0016070 219 0.037
organic substance biosynthetic process GO:1901576 289 0.036
positive regulation of cell cycle GO:0045787 3 0.036
regulation of meiotic cell cycle GO:0051445 1 0.036
chordate embryonic development GO:0043009 271 0.036
regulation of nucleocytoplasmic transport GO:0046822 2 0.036
proteasomal protein catabolic process GO:0010498 2 0.035
Worm
heterocycle biosynthetic process GO:0018130 215 0.035
cognition GO:0050890 1 0.035
aromatic compound biosynthetic process GO:0019438 217 0.035
regulation of biosynthetic process GO:0009889 250 0.035
protein polymerization GO:0051258 4 0.034
phagocytosis GO:0006909 3 0.034
protein localization to nucleus GO:0034504 3 0.034
negative regulation of catabolic process GO:0009895 3 0.033
regulation of transcription dna templated GO:0006355 213 0.033
organic cyclic compound metabolic process GO:1901360 301 0.033
protein import GO:0017038 3 0.032
positive regulation of biological process GO:0048518 253 0.032
positive regulation of gtp catabolic process GO:0033126 1 0.032
biosynthetic process GO:0009058 294 0.032
regulation of cell death GO:0010941 103 0.032
positive regulation of apoptotic signaling pathway GO:2001235 1 0.031
positive regulation of cellular metabolic process GO:0031325 94 0.031
regulation of nucleic acid templated transcription GO:1903506 213 0.031
positive regulation of cellular process GO:0048522 201 0.031
purine nucleoside monophosphate catabolic process GO:0009128 4 0.031
mitotic dna integrity checkpoint GO:0044774 4 0.030
regulation of protein ubiquitination GO:0031396 3 0.030
regulation of primary metabolic process GO:0080090 311 0.030
organic cyclic compound biosynthetic process GO:1901362 223 0.029
system process GO:0003008 185 0.029
regulation of mrna splicing via spliceosome GO:0048024 3 0.029
mitochondrion organization GO:0007005 4 0.028
programmed cell death GO:0012501 119 0.028
cellular response to external stimulus GO:0071496 2 0.028
response to carbohydrate GO:0009743 3 0.028
cellular component biogenesis GO:0044085 178 0.028
regulation of rna metabolic process GO:0051252 224 0.027
nucleic acid templated transcription GO:0097659 181 0.027
rna transport GO:0050658 2 0.027
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.027
nucleoside monophosphate catabolic process GO:0009125 4 0.027
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.027
apoptotic process GO:0006915 116 0.026
phosphorus metabolic process GO:0006793 109 0.026
regulation of rna biosynthetic process GO:2001141 213 0.026
nuclear envelope organization GO:0006998 2 0.026
macromolecule catabolic process GO:0009057 15 0.026
Worm
gene expression GO:0010467 252 0.025
positive regulation of metabolic process GO:0009893 108 0.025
regulation of oocyte development GO:0060281 3 0.025
regulation of cellular protein catabolic process GO:1903362 1 0.024
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.024
transcription from rna polymerase ii promoter GO:0006366 80 0.024
single organism metabolic process GO:0044710 217 0.024
Worm
multicellular organism growth GO:0035264 4 0.024
autophagy GO:0006914 4 0.023
response to chemical GO:0042221 320 0.023
Worm
cellular component assembly GO:0022607 170 0.023
negative regulation of cellular catabolic process GO:0031330 3 0.023
negative regulation of metabolic process GO:0009892 86 0.023
protein stabilization GO:0050821 2 0.023
erk1 and erk2 cascade GO:0070371 4 0.023
protein targeting to nucleus GO:0044744 3 0.023
mitotic dna damage checkpoint GO:0044773 4 0.022
eye development GO:0001654 277 0.022
negative regulation of cytoplasmic transport GO:1903650 2 0.022
cellular response to starvation GO:0009267 1 0.022
single organism nuclear import GO:1902593 3 0.022
cellular protein metabolic process GO:0044267 129 0.022
Worm
cellular component disassembly GO:0022411 1 0.022
negative regulation of macromolecule metabolic process GO:0010605 76 0.022
single organism intracellular transport GO:1902582 25 0.022
negative regulation of gene expression GO:0010629 65 0.022
peptide transport GO:0015833 1 0.022
regulation of organelle assembly GO:1902115 4 0.021
positive regulation of transport GO:0051050 2 0.021
intracellular signal transduction GO:0035556 85 0.021
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.021
neuron projection morphogenesis GO:0048812 161 0.021
nuclear import GO:0051170 3 0.021
protein complex assembly GO:0006461 30 0.021
homeostatic process GO:0042592 142 0.021
regulation of protein transport GO:0051223 3 0.021
transcription dna templated GO:0006351 181 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
protein secretion GO:0009306 1 0.020
developmental growth GO:0048589 166 0.020
response to glucose GO:0009749 3 0.020
skeletal system development GO:0001501 181 0.020
intracellular transport GO:0046907 32 0.020
cellular component assembly involved in morphogenesis GO:0010927 107 0.020
cell morphogenesis GO:0000902 289 0.020
response to hexose GO:0009746 3 0.020
cellular macromolecule biosynthetic process GO:0034645 224 0.020
regulation of reproductive process GO:2000241 4 0.020
glucose homeostasis GO:0042593 1 0.020
regulation of gtp catabolic process GO:0033124 2 0.020
establishment of localization in cell GO:0051649 77 0.020
positive regulation of gtpase activity GO:0043547 1 0.020
organic substance catabolic process GO:1901575 28 0.020
Worm
regulation of protein targeting GO:1903533 2 0.020
synaptic growth at neuromuscular junction GO:0051124 2 0.020
cellular response to stress GO:0033554 62 0.020
Worm
pericardium development GO:0060039 1 0.019
regulation of intracellular protein transport GO:0033157 3 0.019
regulation of molecular function GO:0065009 70 0.019
regulation of multicellular organism growth GO:0040014 4 0.019
mitotic g2 m transition checkpoint GO:0044818 3 0.019
positive regulation of nucleoside metabolic process GO:0045979 1 0.019
circadian sleep wake cycle process GO:0022410 2 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.019
cell projection morphogenesis GO:0048858 244 0.019
adult behavior GO:0030534 2 0.019
myeloid cell differentiation GO:0030099 86 0.019
maturation of ssu rrna GO:0030490 1 0.019
negative regulation of cellular process GO:0048523 283 0.018
mesoderm development GO:0007498 88 0.018
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.018
er to golgi vesicle mediated transport GO:0006888 1 0.018
cell cycle g1 s phase transition GO:0044843 1 0.018
g1 s transition of mitotic cell cycle GO:0000082 1 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.018
protein import into nucleus GO:0006606 3 0.018
catabolic process GO:0009056 32 0.017
Worm
generation of neurons GO:0048699 385 0.017
neuron projection development GO:0031175 180 0.017
multi organism process GO:0051704 134 0.017
regulation of multicellular organismal process GO:0051239 277 0.017
positive regulation of nucleotide catabolic process GO:0030813 1 0.017
regulation of synapse assembly GO:0051963 3 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.017
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
positive regulation of cellular biosynthetic process GO:0031328 68 0.016
regulation of nucleotide catabolic process GO:0030811 2 0.016
single organism membrane organization GO:0044802 20 0.016
regulation of gtpase activity GO:0043087 2 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.016
cellular macromolecule catabolic process GO:0044265 12 0.016
Worm
macromolecular complex disassembly GO:0032984 1 0.016
cellular component movement GO:0006928 335 0.016
protein metabolic process GO:0019538 183 0.016
Worm
golgi vesicle transport GO:0048193 3 0.016
vasculature development GO:0001944 278 0.016
negative regulation of protein localization to nucleus GO:1900181 2 0.016
meiotic nuclear division GO:0007126 4 0.016
posttranscriptional regulation of gene expression GO:0010608 14 0.016
centrosome organization GO:0051297 1 0.016
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
regulation of cell communication GO:0010646 232 0.015
growth GO:0040007 174 0.015
negative regulation of chromosome organization GO:2001251 1 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
regulation of response to stimulus GO:0048583 269 0.015
regulation of response to extracellular stimulus GO:0032104 1 0.015
cell fate commitment GO:0045165 99 0.015
atp catabolic process GO:0006200 4 0.015
negative regulation of protein maturation GO:1903318 10 0.015
mitotic cell cycle GO:0000278 64 0.015
carbohydrate homeostasis GO:0033500 1 0.015
positive regulation of macromolecule metabolic process GO:0010604 93 0.015
nephron epithelium morphogenesis GO:0072088 1 0.014
single organism behavior GO:0044708 24 0.014
g2 dna damage checkpoint GO:0031572 3 0.014
nucleobase containing compound catabolic process GO:0034655 15 0.014
dna biosynthetic process GO:0071897 3 0.014
organism emergence from protective structure GO:0071684 4 0.014
alternative mrna splicing via spliceosome GO:0000380 1 0.014
morphogenesis of an epithelium GO:0002009 333 0.014
organic substance transport GO:0071702 58 0.014
circadian rhythm GO:0007623 19 0.014
regulation of programmed cell death GO:0043067 101 0.014
organonitrogen compound metabolic process GO:1901564 74 0.014
dna templated transcription elongation GO:0006354 3 0.014
regulation of anatomical structure morphogenesis GO:0022603 130 0.014
regulation of protein binding GO:0043393 3 0.014
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.014
circadian sleep wake cycle GO:0042745 2 0.014
response to external stimulus GO:0009605 264 0.014
regulation of erk1 and erk2 cascade GO:0070372 4 0.014
neuron development GO:0048666 262 0.014
dorsal ventral pattern formation GO:0009953 125 0.014
extrinsic apoptotic signaling pathway GO:0097191 3 0.014
rna export from nucleus GO:0006405 1 0.014
response to stress GO:0006950 263 0.014
Worm
compound eye development GO:0048749 2 0.014
regulation of intracellular signal transduction GO:1902531 57 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
Worm
protein localization to plasma membrane GO:0072659 1 0.013
negative regulation of mapk cascade GO:0043409 4 0.013
regulation of synapse organization GO:0050807 3 0.013
macroautophagy GO:0016236 1 0.013
negative regulation of cellular metabolic process GO:0031324 77 0.013
meiotic cell cycle process GO:1903046 3 0.013
organelle fission GO:0048285 23 0.013
regulation of autophagy GO:0010506 3 0.013
negative regulation of protein import into nucleus GO:0042308 2 0.013
regulation of rho protein signal transduction GO:0035023 2 0.013
mesenchymal cell development GO:0014031 78 0.013
nucleobase containing compound transport GO:0015931 2 0.013
striated muscle cell development GO:0055002 108 0.013
regulation of inflammatory response GO:0050727 2 0.013
negative regulation of protein kinase activity GO:0006469 4 0.013
muscle structure development GO:0061061 196 0.013
microtubule based movement GO:0007018 33 0.013
regulation of jak stat cascade GO:0046425 3 0.013
regulation of developmental process GO:0050793 247 0.013
liver development GO:0001889 96 0.013
cellular amide metabolic process GO:0043603 4 0.013
response to monosaccharide GO:0034284 3 0.012
organelle transport along microtubule GO:0072384 1 0.012
establishment of rna localization GO:0051236 3 0.012
positive regulation of signal transduction GO:0009967 56 0.012
negative regulation of intracellular protein transport GO:0090317 3 0.012
nucleic acid transport GO:0050657 2 0.012
organelle assembly GO:0070925 110 0.012
ribonucleoside monophosphate catabolic process GO:0009158 4 0.012
regulation of catalytic activity GO:0050790 55 0.012
mrna metabolic process GO:0016071 20 0.012
glucose import GO:0046323 2 0.012
cell cycle process GO:0022402 53 0.012
protein modification by small protein removal GO:0070646 1 0.012
membrane invagination GO:0010324 1 0.012
female sex differentiation GO:0046660 4 0.012
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.012
embryonic organ morphogenesis GO:0048562 274 0.012
determination of left right symmetry GO:0007368 179 0.012
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.012
stem cell fate commitment GO:0048865 1 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
mesenchyme development GO:0060485 127 0.012
macromolecule localization GO:0033036 54 0.012
neuroblast proliferation GO:0007405 2 0.012
entrainment of circadian clock GO:0009649 2 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
organelle organization GO:0006996 227 0.011
cellular response to light stimulus GO:0071482 4 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
cellular amine metabolic process GO:0044106 2 0.011
somatic muscle development GO:0007525 4 0.011
protein polyubiquitination GO:0000209 4 0.011
negative regulation of protein transport GO:0051224 3 0.011
chromosome organization involved in meiosis GO:0070192 1 0.011
embryonic cranial skeleton morphogenesis GO:0048701 90 0.011
positive regulation of biosynthetic process GO:0009891 68 0.011
regulation of ras gtpase activity GO:0032318 2 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
negative regulation of response to cytokine stimulus GO:0060761 2 0.011
regulation of glucose transport GO:0010827 1 0.011
epiboly GO:0090504 41 0.011
regulation of cell matrix adhesion GO:0001952 1 0.011
protein homooligomerization GO:0051260 3 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.011
phagocytosis engulfment GO:0006911 1 0.011
protein complex disassembly GO:0043241 1 0.011
camera type eye development GO:0043010 222 0.011
cytokinesis GO:0000910 3 0.011
regulation of response to nutrient levels GO:0032107 1 0.011
rna localization GO:0006403 4 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
phosphate containing compound metabolic process GO:0006796 108 0.011
type b pancreatic cell development GO:0003323 4 0.011
mitotic g2 dna damage checkpoint GO:0007095 3 0.011
regulation of binding GO:0051098 3 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
convergent extension GO:0060026 118 0.011
cytoskeleton dependent cytokinesis GO:0061640 3 0.011
regulation of cell development GO:0060284 100 0.011
cellular response to organic substance GO:0071310 105 0.011
Worm
positive regulation of translation GO:0045727 1 0.011
regulation of cell shape GO:0008360 1 0.011
small molecule metabolic process GO:0044281 77 0.011
response to nutrient GO:0007584 3 0.010
axonogenesis GO:0007409 152 0.010
response to uv GO:0009411 3 0.010
membrane fusion GO:0061025 2 0.010
regulation of protein complex disassembly GO:0043244 1 0.010
tube morphogenesis GO:0035239 349 0.010
peptidyl serine phosphorylation GO:0018105 1 0.010
negative regulation of biosynthetic process GO:0009890 55 0.010
mitotic nuclear division GO:0007067 18 0.010
positive regulation of jun kinase activity GO:0043507 2 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.010
regulation of organ growth GO:0046620 3 0.010
mitochondrial transport GO:0006839 2 0.010
hard palate development GO:0060022 4 0.010
amine metabolic process GO:0009308 2 0.010
translational initiation GO:0006413 3 0.010
kidney development GO:0001822 92 0.010
skeletal system morphogenesis GO:0048705 102 0.010
negative regulation of ras protein signal transduction GO:0046580 1 0.010
regulation of microtubule cytoskeleton organization GO:0070507 3 0.010
sex determination GO:0007530 1 0.010

nploc4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
organ system cancer DOID:0050686 0 0.025
nervous system disease DOID:863 0 0.015
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013
eye disease DOID:5614 0 0.013