Danio rerio

48 known processes

nrxn2a

neurexin 2a

nrxn2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell morphogenesis GO:0000902 289 0.557
response to external stimulus GO:0009605 264 0.383
mechanosensory behavior GO:0007638 2 0.382
Human
embryonic camera type eye development GO:0031076 29 0.342
neuron neuron synaptic transmission GO:0007270 1 0.296
eye development GO:0001654 277 0.285
sensory organ development GO:0007423 393 0.251
digestive tract development GO:0048565 265 0.229
cation transmembrane transport GO:0098655 65 0.215
Mouse
neuron projection morphogenesis GO:0048812 161 0.214
regulation of cell development GO:0060284 100 0.211
locomotion GO:0040011 313 0.186
cellular component morphogenesis GO:0032989 336 0.169
motor neuron axon guidance GO:0008045 23 0.165
response to chemical GO:0042221 320 0.164
camera type eye development GO:0043010 222 0.159
monoamine transport GO:0015844 1 0.153
cell surface receptor signaling pathway GO:0007166 325 0.130
signal transduction GO:0007165 455 0.123
axon development GO:0061564 166 0.110
ion transmembrane transport GO:0034220 91 0.105
Mouse
neurotransmitter transport GO:0006836 2 0.100
Mouse
embryonic organ development GO:0048568 381 0.098
regulation of axonogenesis GO:0050770 32 0.088
spinal cord development GO:0021510 46 0.088
regulation of system process GO:0044057 40 0.087
muscle hypertrophy GO:0014896 2 0.085
regulation of neurogenesis GO:0050767 87 0.084
extrinsic apoptotic signaling pathway GO:0097191 3 0.083
regulation of cell differentiation GO:0045595 142 0.081
regulation of multicellular organismal process GO:0051239 277 0.078
neuron projection guidance GO:0097485 86 0.077
central nervous system development GO:0007417 387 0.076
positive regulation of biological process GO:0048518 253 0.075
Fly
homeostatic process GO:0042592 142 0.073
cellular component assembly GO:0022607 170 0.070
Mouse Fly
generation of neurons GO:0048699 385 0.068
regulation of anatomical structure morphogenesis GO:0022603 130 0.067
central nervous system neuron differentiation GO:0021953 74 0.066
cell projection organization GO:0030030 284 0.064
cell part morphogenesis GO:0032990 246 0.063
blood vessel morphogenesis GO:0048514 216 0.063
Zebrafish
cell morphogenesis involved in differentiation GO:0000904 195 0.062
neuron development GO:0048666 262 0.061
larval development GO:0002164 2 0.059
regulation of developmental process GO:0050793 247 0.056
transmembrane transport GO:0055085 120 0.056
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.055
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.054
regulation of signaling GO:0023051 235 0.054
Fly
regulation of response to stimulus GO:0048583 269 0.053
specification of organ identity GO:0010092 2 0.050
adult behavior GO:0030534 2 0.048
Human
response to alkaloid GO:0043279 2 0.047
ion transport GO:0006811 114 0.046
Mouse
retina development in camera type eye GO:0060041 146 0.046
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.045
regulation of synapse organization GO:0050807 3 0.045
Fly
gabaergic neuron differentiation GO:0097154 2 0.044
cellular macromolecule metabolic process GO:0044260 391 0.044
cell projection morphogenesis GO:0048858 244 0.044
organic acid metabolic process GO:0006082 31 0.043
regulation of biological quality GO:0065008 263 0.042
Mouse Fly
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.042
muscle structure development GO:0061061 196 0.042
neuron differentiation GO:0030182 353 0.041
synaptic transmission glycinergic GO:0060012 1 0.041
cellular biosynthetic process GO:0044249 286 0.041
taxis GO:0042330 109 0.041
digestive system development GO:0055123 289 0.041
regulation of stem cell proliferation GO:0072091 2 0.041
axonogenesis GO:0007409 152 0.040
regulation of multicellular organismal development GO:2000026 223 0.040
regulation of molecular function GO:0065009 70 0.040
amine metabolic process GO:0009308 2 0.039
response to abiotic stimulus GO:0009628 122 0.039
Human
multicellular organismal response to stress GO:0033555 2 0.038
female gonad development GO:0008585 4 0.037
regulation of hormone secretion GO:0046883 2 0.037
development of primary female sexual characteristics GO:0046545 4 0.037
peripheral nervous system development GO:0007422 55 0.036
carbohydrate homeostasis GO:0033500 1 0.036
digestive tract morphogenesis GO:0048546 231 0.035
inner ear morphogenesis GO:0042472 63 0.035
response to carbohydrate GO:0009743 3 0.035
positive regulation of axonogenesis GO:0050772 6 0.034
regulation of neurological system process GO:0031644 2 0.034
endocrine process GO:0050886 2 0.033
single organism transport GO:0044765 206 0.032
Mouse Fly
neuron projection extension GO:1990138 45 0.032
nephron morphogenesis GO:0072028 2 0.032
response to decreased oxygen levels GO:0036293 25 0.032
neuron fate commitment GO:0048663 26 0.031
tube morphogenesis GO:0035239 349 0.031
negative regulation of cell communication GO:0010648 96 0.031
regulation of cell communication GO:0010646 232 0.031
Fly
regulation of synaptic plasticity GO:0048167 1 0.031
response to oxygen levels GO:0070482 25 0.030
oxoacid metabolic process GO:0043436 31 0.030
negative regulation of response to stimulus GO:0048585 104 0.030
endocrine system development GO:0035270 65 0.030
establishment of localization GO:0051234 244 0.030
Mouse Fly
protein heterooligomerization GO:0051291 1 0.030
positive regulation of cellular process GO:0048522 201 0.029
Fly
programmed cell death GO:0012501 119 0.029
regulation of rna metabolic process GO:0051252 224 0.029
brain development GO:0007420 293 0.029
embryonic eye morphogenesis GO:0048048 30 0.029
axon guidance GO:0007411 86 0.029
nucleobase containing compound metabolic process GO:0006139 274 0.029
centrosome organization GO:0051297 1 0.029
nuclear transport GO:0051169 4 0.028
stem cell maintenance GO:0019827 4 0.028
regulation of cell size GO:0008361 29 0.027
embryonic camera type eye morphogenesis GO:0048596 19 0.027
regulation of axon extension GO:0030516 24 0.027
nerve development GO:0021675 45 0.027
cation transport GO:0006812 81 0.026
Mouse
response to oxygen containing compound GO:1901700 55 0.026
negative regulation of biological process GO:0048519 304 0.026
gastrulation GO:0007369 208 0.026
directional locomotion GO:0033058 1 0.026
neuromuscular synaptic transmission GO:0007274 2 0.026
Fly
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.026
cognition GO:0050890 1 0.025
Human Fly
apoptotic process GO:0006915 116 0.025
behavior GO:0007610 74 0.025
Human Fly
regulation of extent of cell growth GO:0061387 29 0.025
energy reserve metabolic process GO:0006112 2 0.025
dorsal ventral pattern formation GO:0009953 125 0.025
single organism localization GO:1902578 225 0.024
Mouse Fly
regulation of anatomical structure size GO:0090066 33 0.024
phasic smooth muscle contraction GO:0014821 1 0.024
establishment of protein localization to organelle GO:0072594 4 0.024
smooth muscle contraction GO:0006939 2 0.023
sensory organ morphogenesis GO:0090596 200 0.023
regulation of postsynaptic membrane potential GO:0060078 1 0.023
cell differentiation in spinal cord GO:0021515 40 0.023
canonical wnt signaling pathway GO:0060070 48 0.023
developmental growth GO:0048589 166 0.023
Fly
ventral spinal cord development GO:0021517 35 0.023
regulation of apoptotic process GO:0042981 98 0.023
ventral spinal cord interneuron differentiation GO:0021514 12 0.023
regulation of cellular metabolic process GO:0031323 320 0.022
negative regulation of signaling GO:0023057 96 0.022
fin development GO:0033333 77 0.022
regulation of protein transport GO:0051223 3 0.022
response to amphetamine GO:0001975 1 0.022
cell cell signaling GO:0007267 52 0.022
autonomic nervous system development GO:0048483 19 0.022
regulation of multicellular organism growth GO:0040014 4 0.022
catecholamine metabolic process GO:0006584 2 0.021
locomotory behavior GO:0007626 34 0.021
response to heat GO:0009408 6 0.021
spinal cord motor neuron differentiation GO:0021522 26 0.021
regulation of signal transduction GO:0009966 225 0.021
lateral line development GO:0048882 66 0.021
erythrocyte differentiation GO:0030218 54 0.020
regulation of neuron projection development GO:0010975 40 0.020
regulation of protein binding GO:0043393 3 0.020
positive regulation of catabolic process GO:0009896 4 0.020
reflex GO:0060004 2 0.020
protein targeting to nucleus GO:0044744 3 0.020
cell motility GO:0048870 244 0.019
protein complex biogenesis GO:0070271 30 0.019
cell death GO:0008219 121 0.019
regulation of skeletal muscle tissue development GO:0048641 4 0.019
response to metal ion GO:0010038 34 0.019
negative regulation of cellular process GO:0048523 283 0.019
glucose homeostasis GO:0042593 1 0.019
regulation of blood pressure GO:0008217 1 0.019
response to stress GO:0006950 263 0.018
regulation of macromolecule metabolic process GO:0060255 317 0.018
regulation of neuron differentiation GO:0045664 56 0.018
regulation of dendrite development GO:0050773 3 0.018
eye morphogenesis GO:0048592 144 0.018
response to inorganic substance GO:0010035 38 0.018
regulation of cell death GO:0010941 103 0.018
primitive erythrocyte differentiation GO:0060319 5 0.018
microtubule organizing center organization GO:0031023 1 0.018
nucleocytoplasmic transport GO:0006913 4 0.018
convergent extension involved in gastrulation GO:0060027 71 0.018
macromolecule biosynthetic process GO:0009059 227 0.018
neuron fate specification GO:0048665 20 0.018
negative regulation of protein kinase b signaling GO:0051898 2 0.017
positive regulation of multicellular organismal process GO:0051240 52 0.017
leukocyte proliferation GO:0070661 1 0.017
regulation of gene expression GO:0010468 265 0.017
circadian sleep wake cycle process GO:0022410 2 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
positive regulation of secretion GO:0051047 1 0.017
organic substance biosynthetic process GO:1901576 289 0.017
neurotransmitter secretion GO:0007269 2 0.017
Mouse
type b pancreatic cell development GO:0003323 4 0.017
transport GO:0006810 220 0.017
Mouse Fly
chemosensory behavior GO:0007635 1 0.017
neuron projection development GO:0031175 180 0.017
hormone secretion GO:0046879 2 0.017
regulation of neuron migration GO:2001222 2 0.017
regionalization GO:0003002 274 0.017
cell fate commitment GO:0045165 99 0.017
kidney development GO:0001822 92 0.017
response to endogenous stimulus GO:0009719 83 0.017
branching morphogenesis of a nerve GO:0048755 4 0.017
regulation of cellular component size GO:0032535 30 0.016
cranial nerve development GO:0021545 42 0.016
homeostasis of number of cells GO:0048872 62 0.016
cell growth GO:0016049 57 0.016
cellular component movement GO:0006928 335 0.016
response to glucose GO:0009749 3 0.016
response to hypoxia GO:0001666 25 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
negative regulation of mesodermal cell fate specification GO:0042662 3 0.016
developmental cell growth GO:0048588 52 0.016
hormone transport GO:0009914 2 0.016
inner ear receptor cell differentiation GO:0060113 29 0.016
regulation of nitrogen compound metabolic process GO:0051171 251 0.016
regulation of axon extension involved in axon guidance GO:0048841 6 0.016
ubiquitin dependent protein catabolic process GO:0006511 3 0.016
regulation of membrane potential GO:0042391 23 0.015
cellular component biogenesis GO:0044085 178 0.015
Mouse Fly
hepaticobiliary system development GO:0061008 98 0.015
localization of cell GO:0051674 244 0.015
negative regulation of signal transduction GO:0009968 94 0.015
negative regulation of programmed cell death GO:0043069 58 0.015
notochord development GO:0030903 54 0.015
pancreatic a cell development GO:0003322 2 0.015
regulation of cell growth GO:0001558 29 0.015
cellular response to chemical stimulus GO:0070887 157 0.015
organonitrogen compound metabolic process GO:1901564 74 0.015
centrosome cycle GO:0007098 1 0.015
spinal cord motor neuron cell fate specification GO:0021520 8 0.015
pronephros development GO:0048793 69 0.015
mitochondrion organization GO:0007005 4 0.015
positive regulation of neuron differentiation GO:0045666 12 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.015
negative regulation of cell death GO:0060548 60 0.015
cellular response to oxygen levels GO:0071453 1 0.014
reactive oxygen species metabolic process GO:0072593 6 0.014
cellular localization GO:0051641 97 0.014
Mouse Fly
response to monosaccharide GO:0034284 3 0.014
developmental programmed cell death GO:0010623 4 0.014
apoptotic process involved in development GO:1902742 2 0.014
striated muscle cell development GO:0055002 108 0.014
organic substance transport GO:0071702 58 0.014
Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.014
stem cell proliferation GO:0072089 4 0.014
pharyngeal muscle development GO:0043282 4 0.014
gland development GO:0048732 143 0.014
gene expression GO:0010467 252 0.014
cellular aromatic compound metabolic process GO:0006725 295 0.014
positive regulation of cell cycle GO:0045787 3 0.014
establishment of localization in cell GO:0051649 77 0.014
Mouse Fly
multicellular organismal signaling GO:0035637 22 0.014
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.014
regulation of cell migration GO:0030334 40 0.014
regulation of cell motility GO:2000145 46 0.014
amino acid transport GO:0006865 2 0.014
positive regulation of cell development GO:0010720 25 0.013
peristalsis GO:0030432 1 0.013
nephron epithelium morphogenesis GO:0072088 1 0.013
protein metabolic process GO:0019538 183 0.013
small molecule metabolic process GO:0044281 77 0.013
photoreceptor cell fate commitment GO:0046552 1 0.013
transcription dna templated GO:0006351 181 0.013
response to hexose GO:0009746 3 0.013
regulation of binding GO:0051098 3 0.013
cellular response to organic substance GO:0071310 105 0.013
nephron tubule morphogenesis GO:0072078 1 0.013
forebrain neuron differentiation GO:0021879 14 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
regulation of reactive oxygen species metabolic process GO:2000377 2 0.013
maintenance of location GO:0051235 4 0.013
regulation of circadian rhythm GO:0042752 4 0.013
positive regulation of developmental process GO:0051094 50 0.013
glutamate receptor signaling pathway GO:0007215 1 0.013
embryonic camera type eye formation GO:0060900 10 0.013
nitrogen compound transport GO:0071705 23 0.013
chemical homeostasis GO:0048878 49 0.013
dendrite guidance GO:0070983 0 0.013
positive regulation of cellular catabolic process GO:0031331 3 0.013
ear development GO:0043583 127 0.013
nuclear import GO:0051170 3 0.012
chemotaxis GO:0006935 104 0.012
regulation of programmed cell death GO:0043067 101 0.012
fatty acid transport GO:0015908 1 0.012
positive regulation of nervous system development GO:0051962 25 0.012
regulation of cellular component movement GO:0051270 55 0.012
response to wounding GO:0009611 116 0.012
regulation of protein modification process GO:0031399 29 0.012
regulation of establishment of protein localization GO:0070201 4 0.012
neuron projection regeneration GO:0031102 16 0.012
positive regulation of transport GO:0051050 2 0.012
Fly
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.012
nitrogen compound metabolic process GO:0006807 319 0.012
regulation of response to extracellular stimulus GO:0032104 1 0.012
muscle organ development GO:0007517 101 0.012
myotube differentiation GO:0014902 45 0.012
regulation of metabolic process GO:0019222 359 0.012
neuronal action potential GO:0019228 18 0.012
female sex differentiation GO:0046660 4 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
wnt signaling pathway GO:0016055 80 0.011
post embryonic organ morphogenesis GO:0048563 1 0.011
transmission of nerve impulse GO:0019226 19 0.011
neuroblast proliferation GO:0007405 2 0.011
convergent extension GO:0060026 118 0.011
protein localization to nucleus GO:0034504 3 0.011
regulation of synapse assembly GO:0051963 3 0.011
organelle localization GO:0051640 49 0.011
Fly
sensory perception of chemical stimulus GO:0007606 3 0.011
liver development GO:0001889 96 0.011
muscle system process GO:0003012 20 0.011
smooth muscle tissue development GO:0048745 1 0.011
heterocycle biosynthetic process GO:0018130 215 0.011
cellular nitrogen compound biosynthetic process GO:0044271 218 0.011
positive regulation of apoptotic signaling pathway GO:2001235 1 0.011
sensory perception of pain GO:0019233 1 0.011
death GO:0016265 121 0.011
embryo development ending in birth or egg hatching GO:0009792 271 0.011
protein secretion GO:0009306 1 0.011
regulation of response to oxidative stress GO:1902882 2 0.011
lipid metabolic process GO:0006629 52 0.011
regulation of primary metabolic process GO:0080090 311 0.011
macromolecular complex subunit organization GO:0043933 74 0.011
aging GO:0007568 2 0.011
regeneration GO:0031099 91 0.011
primary neural tube formation GO:0014020 1 0.011
regulation of locomotion GO:0040012 55 0.011
Fly
cellular response to decreased oxygen levels GO:0036294 1 0.011
negative regulation of protein phosphorylation GO:0001933 4 0.011
organic cyclic compound biosynthetic process GO:1901362 223 0.010
cellular amine metabolic process GO:0044106 2 0.010
regulation of protein catabolic process GO:0042176 1 0.010
positive regulation of biosynthetic process GO:0009891 68 0.010
formation of primary germ layer GO:0001704 62 0.010
heterocycle metabolic process GO:0046483 290 0.010
appendage morphogenesis GO:0035107 56 0.010
single organism metabolic process GO:0044710 217 0.010
regulation of muscle hypertrophy GO:0014743 2 0.010
regulation of response to nutrient levels GO:0032107 1 0.010
cellular response to hypoxia GO:0071456 1 0.010
regulation of cellular protein catabolic process GO:1903362 1 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.010

nrxn2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
nervous system disease DOID:863 0 0.029
disease of metabolism DOID:0014667 0 0.022
disease of cellular proliferation DOID:14566 0 0.014
immune system disease DOID:2914 0 0.013