Danio rerio

13 known processes

nuf2

NUF2, NDC80 kinetochore complex component, homolog

(Aliases: MGC56708,zgc:56708)

nuf2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.561
maintenance of location GO:0051235 4 0.445
spindle assembly involved in mitosis GO:0090307 1 0.431
embryo development ending in birth or egg hatching GO:0009792 271 0.420
chromosome segregation GO:0007059 12 0.367
nitrogen compound metabolic process GO:0006807 319 0.314
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.312
gene expression GO:0010467 252 0.280
regulation of biological quality GO:0065008 263 0.275
organelle organization GO:0006996 227 0.266
regulation of metabolic process GO:0019222 359 0.256
organic cyclic compound metabolic process GO:1901360 301 0.243
spindle assembly GO:0051225 2 0.233
single organism metabolic process GO:0044710 217 0.212
cellular biosynthetic process GO:0044249 286 0.211
regulation of chromosome segregation GO:0051983 1 0.209
negative regulation of biological process GO:0048519 304 0.199
cellular aromatic compound metabolic process GO:0006725 295 0.187
cellular macromolecule metabolic process GO:0044260 391 0.161
single organism organelle organization GO:1902589 199 0.160
regulation of establishment of protein localization GO:0070201 4 0.151
heart development GO:0007507 313 0.149
heterocycle metabolic process GO:0046483 290 0.148
negative regulation of protein transport GO:0051224 3 0.147
meiotic nuclear division GO:0007126 4 0.144
locomotion GO:0040011 313 0.142
regulation of gene expression GO:0010468 265 0.135
regulation of macromolecule metabolic process GO:0060255 317 0.130
mitotic nuclear division GO:0007067 18 0.129
nuclear division GO:0000280 23 0.125
regulation of protein transport GO:0051223 3 0.124
meiotic chromosome segregation GO:0045132 3 0.121
organelle fission GO:0048285 23 0.118
establishment of protein localization to organelle GO:0072594 4 0.117
cell cycle GO:0007049 93 0.116
meiotic cell cycle process GO:1903046 3 0.115
cellular nitrogen compound metabolic process GO:0034641 290 0.111
single organism nuclear import GO:1902593 3 0.111
single organism localization GO:1902578 225 0.111
nucleic acid metabolic process GO:0090304 244 0.110
negative regulation of cellular process GO:0048523 283 0.109
organic substance biosynthetic process GO:1901576 289 0.108
establishment of localization GO:0051234 244 0.101
cellular macromolecule biosynthetic process GO:0034645 224 0.101
regulation of protein targeting GO:1903533 2 0.098
aromatic compound biosynthetic process GO:0019438 217 0.097
chromosome organization GO:0051276 31 0.095
protein targeting to nucleus GO:0044744 3 0.095
nucleobase containing compound metabolic process GO:0006139 274 0.094
transport GO:0006810 220 0.094
regulation of protein import into nucleus GO:0042306 2 0.093
protein localization to nucleus GO:0034504 3 0.090
reproductive process GO:0022414 40 0.088
microtubule based process GO:0007017 60 0.087
cytoskeleton organization GO:0007010 96 0.086
regulation of nucleocytoplasmic transport GO:0046822 2 0.086
nucleobase containing compound biosynthetic process GO:0034654 205 0.085
modification dependent protein catabolic process GO:0019941 3 0.083
organelle localization GO:0051640 49 0.082
regulation of primary metabolic process GO:0080090 311 0.082
nuclear import GO:0051170 3 0.081
negative regulation of cytoplasmic transport GO:1903650 2 0.081
protein import into nucleus GO:0006606 3 0.081
negative regulation of mitosis GO:0045839 3 0.080
immune system development GO:0002520 191 0.079
positive regulation of biological process GO:0048518 253 0.078
single organism biosynthetic process GO:0044711 71 0.077
cytokinesis GO:0000910 3 0.077
nucleocytoplasmic transport GO:0006913 4 0.077
immune system process GO:0002376 241 0.077
regulation of protein catabolic process GO:0042176 1 0.076
regulation of protein ubiquitination GO:0031396 3 0.075
microtubule cytoskeleton organization GO:0000226 33 0.074
sister chromatid segregation GO:0000819 6 0.074
mitotic sister chromatid segregation GO:0000070 6 0.073
cytoskeleton dependent cytokinesis GO:0061640 3 0.072
negative regulation of protein localization to nucleus GO:1900181 2 0.072
biosynthetic process GO:0009058 294 0.071
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.069
apoptotic process GO:0006915 116 0.068
protein metabolic process GO:0019538 183 0.068
ubiquitin dependent protein catabolic process GO:0006511 3 0.067
negative regulation of nuclear division GO:0051784 3 0.065
cell migration GO:0016477 237 0.064
double strand break repair GO:0006302 3 0.063
regulation of intracellular protein transport GO:0033157 3 0.061
cell cycle process GO:0022402 53 0.060
cellular component movement GO:0006928 335 0.060
nuclear transport GO:0051169 4 0.060
organic cyclic compound biosynthetic process GO:1901362 223 0.059
single fertilization GO:0007338 3 0.059
regulation of nitrogen compound metabolic process GO:0051171 251 0.058
regulation of proteolysis GO:0030162 24 0.058
protein import GO:0017038 3 0.057
regulation of apoptotic process GO:0042981 98 0.056
regulation of cytoplasmic transport GO:1903649 4 0.056
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.056
cellular protein metabolic process GO:0044267 129 0.056
fertilization GO:0009566 3 0.055
negative regulation of macromolecule metabolic process GO:0010605 76 0.054
response to stress GO:0006950 263 0.054
regulation of protein localization to nucleus GO:1900180 2 0.053
cellular nitrogen compound biosynthetic process GO:0044271 218 0.052
mitotic metaphase plate congression GO:0007080 1 0.051
protein modification process GO:0036211 100 0.051
regulation of rna metabolic process GO:0051252 224 0.050
cellular protein catabolic process GO:0044257 4 0.050
organic acid metabolic process GO:0006082 31 0.049
regulation of cellular protein catabolic process GO:1903362 1 0.049
rna metabolic process GO:0016070 219 0.049
heterocycle biosynthetic process GO:0018130 215 0.048
centrosome cycle GO:0007098 1 0.048
hematopoietic or lymphoid organ development GO:0048534 191 0.047
regulation of multicellular organism growth GO:0040014 4 0.046
female meiotic division GO:0007143 2 0.046
proteasomal protein catabolic process GO:0010498 2 0.046
blood vessel morphogenesis GO:0048514 216 0.046
reproduction GO:0000003 40 0.046
negative regulation of cell division GO:0051782 4 0.045
localization of cell GO:0051674 244 0.045
single organism transport GO:0044765 206 0.044
cellular localization GO:0051641 97 0.044
oxoacid metabolic process GO:0043436 31 0.044
angiogenesis GO:0001525 158 0.044
cellular protein modification process GO:0006464 100 0.043
response to abiotic stimulus GO:0009628 122 0.043
regulation of binding GO:0051098 3 0.043
regulation of mitotic cell cycle GO:0007346 25 0.042
negative regulation of intracellular protein transport GO:0090317 3 0.041
protein localization GO:0008104 40 0.041
oocyte maturation GO:0001556 4 0.041
centrosome organization GO:0051297 1 0.041
single organism reproductive process GO:0044702 40 0.040
dna metabolic process GO:0006259 27 0.040
meiosis i GO:0007127 1 0.040
negative regulation of intracellular transport GO:0032387 3 0.040
regulation of meiotic cell cycle GO:0051445 1 0.040
negative regulation of protein import into nucleus GO:0042308 2 0.040
rna localization GO:0006403 4 0.039
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.039
negative regulation of gene expression GO:0010629 65 0.038
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.038
digestive system development GO:0055123 289 0.038
modification dependent macromolecule catabolic process GO:0043632 3 0.038
negative regulation of cellular catabolic process GO:0031330 3 0.038
positive regulation of cellular catabolic process GO:0031331 3 0.038
macromolecule modification GO:0043412 111 0.038
rna biosynthetic process GO:0032774 181 0.038
positive regulation of catabolic process GO:0009896 4 0.037
macromolecular complex subunit organization GO:0043933 74 0.037
stem cell proliferation GO:0072089 4 0.037
regulation of synapse organization GO:0050807 3 0.035
amine metabolic process GO:0009308 2 0.035
nucleic acid templated transcription GO:0097659 181 0.035
positive regulation of cell cycle GO:0045787 3 0.035
macromolecule biosynthetic process GO:0009059 227 0.034
cellular ketone metabolic process GO:0042180 11 0.034
g1 s transition of mitotic cell cycle GO:0000082 1 0.033
cellular component biogenesis GO:0044085 178 0.033
microtubule organizing center organization GO:0031023 1 0.033
regulation of stem cell proliferation GO:0072091 2 0.033
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.033
aging GO:0007568 2 0.032
regulation of cellular metabolic process GO:0031323 320 0.032
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.032
cellular amine metabolic process GO:0044106 2 0.032
centrosome duplication GO:0051298 1 0.031
chordate embryonic development GO:0043009 271 0.031
response to drug GO:0042493 3 0.031
lipid storage GO:0019915 1 0.031
macromolecule localization GO:0033036 54 0.031
muscle structure development GO:0061061 196 0.031
mitotic cytokinesis GO:0000281 3 0.030
positive regulation of transport GO:0051050 2 0.030
cell death GO:0008219 121 0.029
organelle assembly GO:0070925 110 0.029
brain development GO:0007420 293 0.029
reciprocal dna recombination GO:0035825 1 0.029
cell motility GO:0048870 244 0.028
phagocytosis GO:0006909 3 0.028
single organism cellular localization GO:1902580 46 0.027
regulation of cellular amine metabolic process GO:0033238 0 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.027
cellular component assembly GO:0022607 170 0.027
astral microtubule organization GO:0030953 1 0.027
signal transduction GO:0007165 455 0.026
protein acetylation GO:0006473 2 0.026
mononuclear cell proliferation GO:0032943 1 0.026
phosphorus metabolic process GO:0006793 109 0.026
negative regulation of catabolic process GO:0009895 3 0.026
cell surface receptor signaling pathway GO:0007166 325 0.025
carboxylic acid metabolic process GO:0019752 22 0.025
establishment of spindle localization GO:0051293 12 0.025
regulation of signaling GO:0023051 235 0.025
negative regulation of chromosome organization GO:2001251 1 0.025
transcription dna templated GO:0006351 181 0.025
regulation of protein metabolic process GO:0051246 56 0.025
regulation of cell migration GO:0030334 40 0.025
multicellular organism growth GO:0035264 4 0.025
regulation of biosynthetic process GO:0009889 250 0.025
negative regulation of metabolic process GO:0009892 86 0.024
leukocyte proliferation GO:0070661 1 0.024
regulation of cellular ketone metabolic process GO:0010565 7 0.024
cell cycle g1 s phase transition GO:0044843 1 0.023
negative regulation of cellular biosynthetic process GO:0031327 55 0.023
mitotic cell cycle GO:0000278 64 0.023
cellular response to stress GO:0033554 62 0.023
vasculature development GO:0001944 278 0.023
homeostatic process GO:0042592 142 0.023
small molecule metabolic process GO:0044281 77 0.023
regulation of mitotic cell cycle phase transition GO:1901990 8 0.023
cell division GO:0051301 20 0.023
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.022
striated muscle cell development GO:0055002 108 0.022
eye development GO:0001654 277 0.022
hemopoiesis GO:0030097 183 0.022
meiotic spindle organization GO:0000212 1 0.022
cellular protein localization GO:0034613 20 0.022
positive regulation of cellular process GO:0048522 201 0.022
response to chemical GO:0042221 320 0.022
cell proliferation in forebrain GO:0021846 3 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
male meiosis GO:0007140 2 0.021
regulation of response to stimulus GO:0048583 269 0.021
phosphate containing compound metabolic process GO:0006796 108 0.021
macromolecular complex disassembly GO:0032984 1 0.021
cellular macromolecule localization GO:0070727 21 0.020
negative regulation of protein maturation GO:1903318 10 0.020
multi organism process GO:0051704 134 0.020
negative regulation of protein processing GO:0010955 10 0.020
regulation of cell cycle process GO:0010564 20 0.020
reciprocal meiotic recombination GO:0007131 1 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.020
regulation of cell death GO:0010941 103 0.020
regulation of macromolecule biosynthetic process GO:0010556 225 0.020
negative regulation of cell cycle process GO:0010948 9 0.019
regulation of programmed cell death GO:0043067 101 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.019
positive regulation of chromosome organization GO:2001252 1 0.019
chromosome localization GO:0050000 2 0.019
establishment of localization in cell GO:0051649 77 0.019
positive regulation of dna metabolic process GO:0051054 1 0.019
sister chromatid cohesion GO:0007062 2 0.019
microtubule depolymerization GO:0007019 1 0.018
protein complex subunit organization GO:0071822 46 0.018
internal protein amino acid acetylation GO:0006475 2 0.018
rna transport GO:0050658 2 0.018
regulation of localization GO:0032879 104 0.018
regulation of molecular function GO:0065009 70 0.018
peptidyl serine modification GO:0018209 2 0.018
telomere organization GO:0032200 1 0.018
regulation of cellular protein metabolic process GO:0032268 52 0.018
generation of neurons GO:0048699 385 0.018
neuron projection development GO:0031175 180 0.018
muscle cell development GO:0055001 115 0.018
regulation of developmental process GO:0050793 247 0.017
regulation of multicellular organismal process GO:0051239 277 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
digestive tract development GO:0048565 265 0.017
single organism intracellular transport GO:1902582 25 0.017
response to corticosteroid GO:0031960 1 0.017
death GO:0016265 121 0.016
response to external stimulus GO:0009605 264 0.016
germ line stem cell maintenance GO:0030718 2 0.016
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
recombinational repair GO:0000725 1 0.016
regulation of dendrite development GO:0050773 3 0.016
rna 3 end processing GO:0031123 2 0.016
ribonucleoside monophosphate catabolic process GO:0009158 4 0.016
g2 m transition of mitotic cell cycle GO:0000086 4 0.016
peptidyl serine phosphorylation GO:0018105 1 0.016
tube morphogenesis GO:0035239 349 0.016
negative regulation of apoptotic process GO:0043066 55 0.016
negative regulation of mitotic cell cycle GO:0045930 11 0.015
regulation of cellular biosynthetic process GO:0031326 245 0.015
neuron differentiation GO:0030182 353 0.015
atp catabolic process GO:0006200 4 0.015
protein complex disassembly GO:0043241 1 0.015
positive regulation of cellular metabolic process GO:0031325 94 0.015
proteolysis GO:0006508 38 0.015
neural precursor cell proliferation GO:0061351 20 0.015
meiosis ii GO:0007135 1 0.015
blood vessel development GO:0001568 246 0.015
regulation of heart growth GO:0060420 2 0.014
guanosine containing compound metabolic process GO:1901068 4 0.014
establishment of organelle localization GO:0051656 45 0.014
regulation of cell communication GO:0010646 232 0.014
chromosome organization involved in meiosis GO:0070192 1 0.014
organonitrogen compound metabolic process GO:1901564 74 0.014
regulation of purine nucleotide catabolic process GO:0033121 2 0.014
protein acylation GO:0043543 3 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
somatic muscle development GO:0007525 4 0.014
regulation of nucleotide catabolic process GO:0030811 2 0.014
neuron development GO:0048666 262 0.014
gtp catabolic process GO:0006184 2 0.014
lymphocyte proliferation GO:0046651 1 0.014
organic substance transport GO:0071702 58 0.014
peptidyl threonine phosphorylation GO:0018107 1 0.014
homologous chromosome segregation GO:0045143 1 0.014
guanosine containing compound catabolic process GO:1901069 2 0.013
growth GO:0040007 174 0.013
positive regulation of striated muscle tissue development GO:0045844 1 0.013
regulation of multicellular organismal development GO:2000026 223 0.013
positive regulation of histone modification GO:0031058 1 0.013
regulation of rna biosynthetic process GO:2001141 213 0.013
negative regulation of cell cycle GO:0045786 14 0.013
regulation of chromosome organization GO:0033044 5 0.013
cell projection organization GO:0030030 284 0.013
pronuclear migration GO:0035046 1 0.013
neuroblast proliferation GO:0007405 2 0.013
protein depolymerization GO:0051261 1 0.013
cell cycle g2 m phase transition GO:0044839 4 0.013
dna biosynthetic process GO:0071897 3 0.013
head development GO:0060322 303 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
protein polyubiquitination GO:0000209 4 0.013
regulation of transcription dna templated GO:0006355 213 0.013
protein phosphorylation GO:0006468 47 0.013
regulation of transport GO:0051049 45 0.012
cell proliferation GO:0008283 80 0.012
regulation of protein binding GO:0043393 3 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
regulation of signal transduction GO:0009966 225 0.012
nucleotide biosynthetic process GO:0009165 21 0.012
positive regulation of cell division GO:0051781 2 0.012
cellular component morphogenesis GO:0032989 336 0.012
gland development GO:0048732 143 0.012
intracellular signal transduction GO:0035556 85 0.012
negative regulation of rna metabolic process GO:0051253 48 0.012
ameboidal type cell migration GO:0001667 143 0.012
stem cell maintenance GO:0019827 4 0.012
negative regulation of nucleic acid templated transcription GO:1903507 45 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
microtubule polymerization or depolymerization GO:0031109 3 0.012
oxidation reduction process GO:0055114 41 0.012
cellular response to oxygen levels GO:0071453 1 0.012
purine nucleoside monophosphate catabolic process GO:0009128 4 0.012
regulation of cell cycle GO:0051726 52 0.012
regulation of cellular component organization GO:0051128 86 0.012
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
hepatocyte differentiation GO:0070365 1 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.012
striated muscle tissue development GO:0014706 110 0.012
regulation of synaptic plasticity GO:0048167 1 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
regulation of neural precursor cell proliferation GO:2000177 3 0.011
programmed cell death GO:0012501 119 0.011
body morphogenesis GO:0010171 16 0.011
regulation of cell activation GO:0050865 1 0.011
negative regulation of programmed cell death GO:0043069 58 0.011
nuclear migration GO:0007097 3 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
macromolecular complex assembly GO:0065003 35 0.011
anatomical structure homeostasis GO:0060249 36 0.011
developmental process involved in reproduction GO:0003006 27 0.011
glial cell migration GO:0008347 3 0.011
regulation of cell differentiation GO:0045595 142 0.011
spindle localization GO:0051653 12 0.011
muscle cell differentiation GO:0042692 139 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
negative regulation of kinase activity GO:0033673 4 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
positive regulation of chromosome segregation GO:0051984 1 0.011
negative regulation of proteolysis GO:0045861 10 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
central nervous system development GO:0007417 387 0.011
cellular response to external stimulus GO:0071496 2 0.011
cellular component disassembly GO:0022411 1 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.010
anterior posterior pattern specification GO:0009952 152 0.010
regulation of nucleoside metabolic process GO:0009118 2 0.010
multi organism reproductive process GO:0044703 36 0.010
nucleus localization GO:0051647 8 0.010
embryonic digestive tract morphogenesis GO:0048557 3 0.010
regulation of microtubule cytoskeleton organization GO:0070507 3 0.010
phosphorylation GO:0016310 69 0.010
female meiosis chromosome segregation GO:0016321 1 0.010
regeneration GO:0031099 91 0.010
negative regulation of cell death GO:0060548 60 0.010
regulation of dna replication GO:0006275 3 0.010
positive regulation of metabolic process GO:0009893 108 0.010
spindle organization GO:0007051 5 0.010
cell part morphogenesis GO:0032990 246 0.010
response to wounding GO:0009611 116 0.010
hepaticobiliary system development GO:0061008 98 0.010

nuf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.034
disease of cellular proliferation DOID:14566 0 0.034
organ system cancer DOID:0050686 0 0.023
breast cancer DOID:1612 0 0.012
thoracic cancer DOID:5093 0 0.012
disease of metabolism DOID:0014667 0 0.011