Danio rerio

27 known processes

orc1

origin recognition complex, subunit 1

(Aliases: orc1l,zgc:55976,MGC55976,wu:fa11h08)

orc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic substance biosynthetic process GO:1901576 289 0.577
Fly
mitotic dna integrity checkpoint GO:0044774 4 0.458
cellular macromolecule biosynthetic process GO:0034645 224 0.414
Fly
modification dependent protein catabolic process GO:0019941 3 0.403
cellular protein catabolic process GO:0044257 4 0.403
nucleobase containing compound metabolic process GO:0006139 274 0.378
Fly
protein metabolic process GO:0019538 183 0.376
cellular nitrogen compound metabolic process GO:0034641 290 0.366
Fly
organic cyclic compound metabolic process GO:1901360 301 0.328
Fly
regulation of metabolic process GO:0019222 359 0.316
cellular macromolecule metabolic process GO:0044260 391 0.303
Fly
heterocycle metabolic process GO:0046483 290 0.298
Fly
nucleic acid metabolic process GO:0090304 244 0.292
Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.290
Fly
regulation of dna replication GO:0006275 3 0.289
regulation of transcription dna templated GO:0006355 213 0.281
regulation of primary metabolic process GO:0080090 311 0.278
cellular biosynthetic process GO:0044249 286 0.274
Fly
cellular aromatic compound metabolic process GO:0006725 295 0.271
Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.254
negative regulation of mitosis GO:0045839 3 0.248
aromatic compound biosynthetic process GO:0019438 217 0.245
Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.231
Fly
biosynthetic process GO:0009058 294 0.215
Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.208
regulation of protein catabolic process GO:0042176 1 0.208
negative regulation of nuclear division GO:0051784 3 0.197
organic cyclic compound biosynthetic process GO:1901362 223 0.196
Fly
gene expression GO:0010467 252 0.192
regulation of cellular metabolic process GO:0031323 320 0.188
modification dependent macromolecule catabolic process GO:0043632 3 0.180
ubiquitin dependent protein catabolic process GO:0006511 3 0.175
regulation of cellular biosynthetic process GO:0031326 245 0.170
chromatin modification GO:0016568 21 0.169
nitrogen compound metabolic process GO:0006807 319 0.145
Fly
cellular component biogenesis GO:0044085 178 0.141
positive regulation of metabolic process GO:0009893 108 0.134
regulation of protein ubiquitination GO:0031396 3 0.133
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.132
rna metabolic process GO:0016070 219 0.120
regulation of cell cycle GO:0051726 52 0.120
regulation of nucleic acid templated transcription GO:1903506 213 0.118
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.117
positive regulation of biological process GO:0048518 253 0.117
regulation of meiotic cell cycle GO:0051445 1 0.116
macromolecule biosynthetic process GO:0009059 227 0.113
Fly
positive regulation of cell cycle GO:0045787 3 0.113
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.110
cellular protein metabolic process GO:0044267 129 0.108
dna metabolic process GO:0006259 27 0.107
Fly
regulation of macromolecule metabolic process GO:0060255 317 0.102
negative regulation of mitotic cell cycle GO:0045930 11 0.101
g2 dna damage checkpoint GO:0031572 3 0.100
regulation of biosynthetic process GO:0009889 250 0.099
regulation of gene expression GO:0010468 265 0.098
larval development GO:0002164 2 0.097
Worm
positive regulation of macromolecule metabolic process GO:0010604 93 0.097
meiotic chromosome segregation GO:0045132 3 0.097
embryo development ending in birth or egg hatching GO:0009792 271 0.095
Worm
cellular component assembly GO:0022607 170 0.095
positive regulation of catabolic process GO:0009896 4 0.095
g2 m transition of mitotic cell cycle GO:0000086 4 0.094
signal transduction GO:0007165 455 0.092
macromolecule modification GO:0043412 111 0.090
proteasomal protein catabolic process GO:0010498 2 0.090
dna biosynthetic process GO:0071897 3 0.088
Fly
positive regulation of cellular process GO:0048522 201 0.084
rna biosynthetic process GO:0032774 181 0.080
nucleic acid templated transcription GO:0097659 181 0.078
single organism organelle organization GO:1902589 199 0.077
meiotic cell cycle process GO:1903046 3 0.076
immune system process GO:0002376 241 0.075
positive regulation of cellular metabolic process GO:0031325 94 0.074
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.072
transcription dna templated GO:0006351 181 0.071
single organism biosynthetic process GO:0044711 71 0.070
mitotic g2 m transition checkpoint GO:0044818 3 0.070
cellular component morphogenesis GO:0032989 336 0.069
regulation of organelle organization GO:0033043 29 0.068
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.066
mitotic cell cycle process GO:1903047 48 0.066
double strand break repair GO:0006302 3 0.066
regulation of rna biosynthetic process GO:2001141 213 0.066
protein modification process GO:0036211 100 0.065
regulation of rna metabolic process GO:0051252 224 0.064
regulation of biological quality GO:0065008 263 0.063
positive regulation of gene expression GO:0010628 71 0.062
centrosome duplication GO:0051298 1 0.060
cell cycle g2 m phase transition GO:0044839 4 0.059
response to stress GO:0006950 263 0.058
chromatin organization GO:0006325 22 0.058
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.057
centrosome organization GO:0051297 1 0.055
negative regulation of cellular process GO:0048523 283 0.055
stem cell maintenance GO:0019827 4 0.055
histone phosphorylation GO:0016572 2 0.054
cytokinesis GO:0000910 3 0.053
response to alkaloid GO:0043279 2 0.052
cellular catabolic process GO:0044248 27 0.052
amine metabolic process GO:0009308 2 0.051
nuclear import GO:0051170 3 0.051
regulation of protein complex assembly GO:0043254 3 0.051
cellular protein modification process GO:0006464 100 0.050
aging GO:0007568 2 0.050
negative regulation of transcription dna templated GO:0045892 45 0.050
gland development GO:0048732 143 0.050
negative regulation of metabolic process GO:0009892 86 0.048
single organism metabolic process GO:0044710 217 0.048
protein import GO:0017038 3 0.047
programmed cell death GO:0012501 119 0.047
cellular ketone metabolic process GO:0042180 11 0.047
regulation of macromolecule biosynthetic process GO:0010556 225 0.047
regulation of protein import into nucleus GO:0042306 2 0.047
cellular response to external stimulus GO:0071496 2 0.046
proteolysis GO:0006508 38 0.045
establishment of localization GO:0051234 244 0.044
response to abiotic stimulus GO:0009628 122 0.044
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.043
sex determination GO:0007530 1 0.043
cell cycle GO:0007049 93 0.043
mitotic cell cycle embryonic GO:0045448 2 0.043
negative regulation of cellular biosynthetic process GO:0031327 55 0.043
cellular response to stress GO:0033554 62 0.043
oocyte maturation GO:0001556 4 0.042
negative regulation of biological process GO:0048519 304 0.042
developmental growth GO:0048589 166 0.042
regulation of mitotic cell cycle GO:0007346 25 0.042
establishment of protein localization to organelle GO:0072594 4 0.041
regulation of cytoplasmic transport GO:1903649 4 0.040
homeostatic process GO:0042592 142 0.040
mitotic cell cycle GO:0000278 64 0.040
g1 s transition of mitotic cell cycle GO:0000082 1 0.040
microtubule organizing center organization GO:0031023 1 0.039
dna replication checkpoint GO:0000076 1 0.038
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.037
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.036
centrosome cycle GO:0007098 1 0.036
multicellular organism growth GO:0035264 4 0.036
double strand break repair via homologous recombination GO:0000724 1 0.036
mitotic dna damage checkpoint GO:0044773 4 0.035
positive regulation of cellular catabolic process GO:0031331 3 0.035
negative regulation of nucleic acid templated transcription GO:1903507 45 0.035
carboxylic acid metabolic process GO:0019752 22 0.035
peptidyl threonine modification GO:0018210 1 0.034
regulation of cell cycle phase transition GO:1901987 8 0.034
regulation of protein targeting GO:1903533 2 0.034
negative regulation of chromosome organization GO:2001251 1 0.034
death GO:0016265 121 0.033
transcription from rna polymerase ii promoter GO:0006366 80 0.033
single organism nuclear import GO:1902593 3 0.033
growth GO:0040007 174 0.033
regulation of establishment of protein localization GO:0070201 4 0.033
response to light stimulus GO:0009416 46 0.032
negative regulation of cytoplasmic transport GO:1903650 2 0.032
anterior posterior pattern specification GO:0009952 152 0.031
intra s dna damage checkpoint GO:0031573 1 0.031
cell projection morphogenesis GO:0048858 244 0.031
pancreas development GO:0031016 84 0.031
negative regulation of macromolecule metabolic process GO:0010605 76 0.031
regulation of cellular component organization GO:0051128 86 0.031
heterocycle biosynthetic process GO:0018130 215 0.030
Fly
protein targeting to nucleus GO:0044744 3 0.030
positive regulation of rna metabolic process GO:0051254 59 0.030
negative regulation of dna metabolic process GO:0051053 4 0.030
striated muscle cell development GO:0055002 108 0.030
dna alkylation GO:0006305 8 0.029
transport GO:0006810 220 0.029
regulation of proteolysis GO:0030162 24 0.029
organelle assembly GO:0070925 110 0.029
peptidyl serine phosphorylation GO:0018105 1 0.029
regulation of dna metabolic process GO:0051052 11 0.029
protein complex assembly GO:0006461 30 0.029
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.029
negative regulation of rna biosynthetic process GO:1902679 45 0.029
single organism reproductive process GO:0044702 40 0.029
Worm
protein polymerization GO:0051258 4 0.028
heart development GO:0007507 313 0.028
response to uv GO:0009411 3 0.028
regulation of cellular protein metabolic process GO:0032268 52 0.028
phosphate containing compound metabolic process GO:0006796 108 0.027
response to external stimulus GO:0009605 264 0.027
cell morphogenesis GO:0000902 289 0.027
negative regulation of cellular metabolic process GO:0031324 77 0.027
cytoskeleton organization GO:0007010 96 0.027
maintenance of location GO:0051235 4 0.027
organelle organization GO:0006996 227 0.027
positive regulation of histone modification GO:0031058 1 0.026
negative regulation of biosynthetic process GO:0009890 55 0.026
regulation of nucleocytoplasmic transport GO:0046822 2 0.026
regulation of cellular ketone metabolic process GO:0010565 7 0.026
cell cycle g1 s phase transition GO:0044843 1 0.026
central nervous system development GO:0007417 387 0.026
nucleocytoplasmic transport GO:0006913 4 0.025
response to chemical GO:0042221 320 0.025
regulation of cell cycle process GO:0010564 20 0.025
positive regulation of chromatin modification GO:1903310 1 0.025
intracellular signal transduction GO:0035556 85 0.025
macromolecule catabolic process GO:0009057 15 0.024
histone modification GO:0016570 20 0.024
positive regulation of rna biosynthetic process GO:1902680 57 0.024
macromolecular complex subunit organization GO:0043933 74 0.024
positive regulation of protein complex assembly GO:0031334 2 0.024
regulation of response to stimulus GO:0048583 269 0.024
regulation of mitosis GO:0007088 9 0.024
positive regulation of chromosome organization GO:2001252 1 0.024
cellular amino acid metabolic process GO:0006520 7 0.024
developmental programmed cell death GO:0010623 4 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.024
protein complex biogenesis GO:0070271 30 0.023
gene silencing GO:0016458 4 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
regulation of cellular protein catabolic process GO:1903362 1 0.023
peptidyl serine modification GO:0018209 2 0.023
organic acid metabolic process GO:0006082 31 0.023
negative regulation of gene expression GO:0010629 65 0.023
cellular amine metabolic process GO:0044106 2 0.023
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.023
positive regulation of molecular function GO:0044093 33 0.023
response to biotic stimulus GO:0009607 97 0.023
cellular macromolecule catabolic process GO:0044265 12 0.023
response to organic substance GO:0010033 153 0.023
apoptotic process GO:0006915 116 0.022
generation of neurons GO:0048699 385 0.022
immune system development GO:0002520 191 0.022
phosphorylation GO:0016310 69 0.022
cellular response to organic substance GO:0071310 105 0.022
regulation of protein localization to nucleus GO:1900180 2 0.022
meiosis i GO:0007127 1 0.021
cellular response to endogenous stimulus GO:0071495 68 0.021
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
multi organism process GO:0051704 134 0.021
neuron development GO:0048666 262 0.021
negative regulation of cell cycle process GO:0010948 9 0.021
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.021
immunoglobulin mediated immune response GO:0016064 3 0.020
dna methylation GO:0006306 8 0.020
guanosine containing compound catabolic process GO:1901069 2 0.020
chordate embryonic development GO:0043009 271 0.020
negative regulation of dna replication GO:0008156 2 0.020
macromolecular complex assembly GO:0065003 35 0.020
nuclear transport GO:0051169 4 0.020
stem cell fate commitment GO:0048865 1 0.020
hematopoietic or lymphoid organ development GO:0048534 191 0.020
protein acetylation GO:0006473 2 0.020
negative regulation of cell cycle phase transition GO:1901988 5 0.020
negative regulation of cell cycle GO:0045786 14 0.020
protein polyubiquitination GO:0000209 4 0.020
microtubule based process GO:0007017 60 0.019
covalent chromatin modification GO:0016569 20 0.019
cell part morphogenesis GO:0032990 246 0.019
cellular macromolecular complex assembly GO:0034622 24 0.019
cellular response to chemical stimulus GO:0070887 157 0.019
spindle assembly GO:0051225 2 0.019
positive regulation of cellular component biogenesis GO:0044089 3 0.019
spindle assembly involved in mitosis GO:0090307 1 0.019
negative regulation of cell cycle g2 m phase transition GO:1902750 1 0.019
cellular component assembly involved in morphogenesis GO:0010927 107 0.019
digestive system development GO:0055123 289 0.019
male meiosis GO:0007140 2 0.018
regulation of intracellular protein transport GO:0033157 3 0.018
positive regulation of transport GO:0051050 2 0.018
gtp metabolic process GO:0046039 4 0.018
phosphorus metabolic process GO:0006793 109 0.018
peptidyl threonine phosphorylation GO:0018107 1 0.018
meiotic nuclear division GO:0007126 4 0.018
dna recombination GO:0006310 5 0.018
mitotic metaphase plate congression GO:0007080 1 0.017
oxoacid metabolic process GO:0043436 31 0.017
regulation of cysteine type endopeptidase activity GO:2000116 21 0.017
striated muscle cell differentiation GO:0051146 129 0.017
stem cell differentiation GO:0048863 117 0.017
production of molecular mediator of immune response GO:0002440 2 0.017
locomotion GO:0040011 313 0.017
Worm
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.017
positive regulation of leukocyte mediated immunity GO:0002705 1 0.016
muscle cell development GO:0055001 115 0.016
regulation of dna templated transcription in response to stress GO:0043620 0 0.016
negative regulation of catabolic process GO:0009895 3 0.016
regulation of organelle assembly GO:1902115 4 0.016
oocyte development GO:0048599 14 0.016
regulation of chromosome organization GO:0033044 5 0.016
organonitrogen compound metabolic process GO:1901564 74 0.016
mitotic g2 dna damage checkpoint GO:0007095 3 0.015
vasculature development GO:0001944 278 0.015
reproductive process GO:0022414 40 0.015
Worm
negative regulation of rna metabolic process GO:0051253 48 0.015
regulation of chromatin organization GO:1902275 5 0.015
guanosine containing compound metabolic process GO:1901068 4 0.015
macromolecule methylation GO:0043414 19 0.015
response to mechanical stimulus GO:0009612 24 0.015
recombinational repair GO:0000725 1 0.015
catabolic process GO:0009056 32 0.015
mitotic recombination GO:0006312 2 0.015
positive regulation of cellular biosynthetic process GO:0031328 68 0.015
ribonucleoside biosynthetic process GO:0042455 2 0.015
protein localization to nucleus GO:0034504 3 0.015
b cell mediated immunity GO:0019724 3 0.015
cell death GO:0008219 121 0.015
organelle fission GO:0048285 23 0.015
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.015
regulation of developmental process GO:0050793 247 0.015
response to radiation GO:0009314 51 0.015
cellular response to dna damage stimulus GO:0006974 24 0.015
tissue remodeling GO:0048771 4 0.015
germ cell development GO:0007281 22 0.014
positive regulation of cell division GO:0051781 2 0.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.014
regulation of cell shape GO:0008360 1 0.014
regulation of binding GO:0051098 3 0.014
muscle structure development GO:0061061 196 0.014
cell motility GO:0048870 244 0.014
regulation of cell proliferation GO:0042127 37 0.014
histone h3 k4 methylation GO:0051568 2 0.014
positive regulation of transcription dna templated GO:0045893 57 0.013
regulation of protein transport GO:0051223 3 0.013
apoptotic signaling pathway GO:0097190 23 0.013
reciprocal dna recombination GO:0035825 1 0.013
positive regulation of cell activation GO:0050867 1 0.013
specification of symmetry GO:0009799 204 0.013
mitotic cell cycle phase transition GO:0044772 9 0.013
phagocytosis GO:0006909 3 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
cell surface receptor signaling pathway GO:0007166 325 0.013
small molecule metabolic process GO:0044281 77 0.013
antimicrobial humoral response GO:0019730 2 0.012
cellular protein complex assembly GO:0043623 19 0.012
positive regulation of cellular protein metabolic process GO:0032270 22 0.012
developmental cell growth GO:0048588 52 0.012
negative regulation of protein transport GO:0051224 3 0.012
immunoglobulin production GO:0002377 1 0.012
internal protein amino acid acetylation GO:0006475 2 0.012
regulation of mitotic cell cycle phase transition GO:1901990 8 0.012
adult behavior GO:0030534 2 0.012
rna localization GO:0006403 4 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.012
regulation of microtubule cytoskeleton organization GO:0070507 3 0.012
positive regulation of nucleic acid templated transcription GO:1903508 57 0.012
response to endogenous stimulus GO:0009719 83 0.012
regulation of protein metabolic process GO:0051246 56 0.011
response to drug GO:0042493 3 0.011
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.011
female meiotic division GO:0007143 2 0.011
chromosome organization GO:0051276 31 0.011
negative regulation of intracellular transport GO:0032387 3 0.011
cell cycle checkpoint GO:0000075 7 0.011
cell migration GO:0016477 237 0.011
response to external biotic stimulus GO:0043207 97 0.011
regulation of multicellular organism growth GO:0040014 4 0.011
positive regulation of programmed cell death GO:0043068 29 0.011
positive regulation of proteolysis GO:0045862 10 0.011
developmental growth involved in morphogenesis GO:0060560 86 0.011
negative regulation of cell division GO:0051782 4 0.011
cellular component movement GO:0006928 335 0.011
protein import into nucleus GO:0006606 3 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
somatic cell dna recombination GO:0016444 1 0.011
cell proliferation GO:0008283 80 0.011
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.010
zymogen activation GO:0031638 3 0.010
regulation of protein modification process GO:0031399 29 0.010
cytoskeleton dependent cytokinesis GO:0061640 3 0.010
organic substance catabolic process GO:1901575 28 0.010
primary neural tube formation GO:0014020 1 0.010
protein modification by small protein conjugation or removal GO:0070647 14 0.010
gtp catabolic process GO:0006184 2 0.010
regulation of response to stress GO:0080134 36 0.010
mitotic nuclear division GO:0007067 18 0.010
negative regulation of response to stimulus GO:0048585 104 0.010
regulation of neural precursor cell proliferation GO:2000177 3 0.010
regulation of catalytic activity GO:0050790 55 0.010
cell cycle phase transition GO:0044770 9 0.010

orc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.067
disease of cellular proliferation DOID:14566 0 0.067
disease of anatomical entity DOID:7 0 0.067
organ system cancer DOID:0050686 0 0.055
nervous system disease DOID:863 0 0.029
thoracic cancer DOID:5093 0 0.029
large intestine cancer DOID:5672 0 0.025
gastrointestinal system cancer DOID:3119 0 0.025
intestinal cancer DOID:10155 0 0.025
colorectal cancer DOID:9256 0 0.025
disease of metabolism DOID:0014667 0 0.011