Danio rerio

45 known processes

otx2

orthodenticle homolog 2

(Aliases: zOtx2,id:ibd2915,zotx-2,MGC136535,zgc:136535)

otx2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aromatic compound biosynthetic process GO:0019438 217 0.997
Human Zebrafish Mouse Worm Fly
brain development GO:0007420 293 0.997
camera type eye morphogenesis GO:0048593 108 0.997
generation of neurons GO:0048699 385 0.996
Human Zebrafish Mouse Worm Fly
neuron differentiation GO:0030182 353 0.994
Human Zebrafish Mouse Worm Fly
eye photoreceptor cell differentiation GO:0001754 45 0.990
Zebrafish Mouse Fly
sensory organ morphogenesis GO:0090596 200 0.989
Zebrafish Mouse Fly
regulation of gene expression GO:0010468 265 0.986
Human Zebrafish Mouse Worm Fly
photoreceptor cell differentiation GO:0046530 55 0.986
Zebrafish Mouse Fly
eye morphogenesis GO:0048592 144 0.985
Zebrafish Mouse Fly
forebrain neuron fate commitment GO:0021877 1 0.981
central nervous system development GO:0007417 387 0.978
nucleic acid templated transcription GO:0097659 181 0.973
Human Zebrafish Mouse Worm Fly
embryonic camera type eye development GO:0031076 29 0.972
camera type eye development GO:0043010 222 0.972
retina development in camera type eye GO:0060041 146 0.970
regulation of macromolecule biosynthetic process GO:0010556 225 0.959
Human Zebrafish Mouse Worm Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.957
Human Zebrafish Mouse Worm Fly
cell morphogenesis GO:0000902 289 0.952
Human Fly
diencephalon development GO:0021536 58 0.947
Mouse
regulation of transcription dna templated GO:0006355 213 0.945
Human Zebrafish Mouse Worm Fly
regulation of macromolecule metabolic process GO:0060255 317 0.934
Human Zebrafish Mouse Worm Fly
regulation of inner ear receptor cell differentiation GO:2000980 1 0.930
eye development GO:0001654 277 0.927
chordate embryonic development GO:0043009 271 0.925
transcription dna templated GO:0006351 181 0.917
Human Zebrafish Mouse Worm Fly
retina morphogenesis in camera type eye GO:0060042 79 0.916
retina layer formation GO:0010842 24 0.915
forebrain neuron development GO:0021884 7 0.913
cell proliferation in forebrain GO:0021846 3 0.913
somitogenesis GO:0001756 87 0.911
Mouse
head development GO:0060322 303 0.908
photoreceptor cell development GO:0042461 40 0.907
Zebrafish Fly
forebrain anterior posterior pattern specification GO:0021797 3 0.907
compound eye development GO:0048749 2 0.905
Fly
cellular biosynthetic process GO:0044249 286 0.903
Human Zebrafish Mouse Worm Fly
regionalization GO:0003002 274 0.900
brain morphogenesis GO:0048854 18 0.899
Mouse
regulation of primary metabolic process GO:0080090 311 0.897
Human Zebrafish Mouse Worm Fly
eye photoreceptor cell development GO:0042462 30 0.894
Zebrafish Fly
forebrain dorsal ventral pattern formation GO:0021798 1 0.893
regulation of mechanoreceptor differentiation GO:0045631 1 0.886
cell fate commitment GO:0045165 99 0.871
Mouse Worm Fly
heterocycle biosynthetic process GO:0018130 215 0.871
Human Zebrafish Mouse Worm Fly
neural tube development GO:0021915 62 0.870
photoreceptor cell fate commitment GO:0046552 1 0.858
Mouse Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.851
Human Zebrafish Mouse Worm Fly
oligodendrocyte cell fate specification GO:0021778 4 0.847
organic cyclic compound metabolic process GO:1901360 301 0.845
Human Zebrafish Mouse Worm Fly
sensory organ development GO:0007423 393 0.842
nucleobase containing compound metabolic process GO:0006139 274 0.842
Human Zebrafish Mouse Worm Fly
neuron development GO:0048666 262 0.837
Human Zebrafish Fly
thalamus development GO:0021794 6 0.829
forebrain regionalization GO:0021871 4 0.828
regulation of biosynthetic process GO:0009889 250 0.824
Human Zebrafish Mouse Worm Fly
rostrocaudal neural tube patterning GO:0021903 29 0.806
neuron projection morphogenesis GO:0048812 161 0.802
Human Fly
embryonic camera type eye morphogenesis GO:0048596 19 0.799
ameboidal type cell migration GO:0001667 143 0.795
cell surface receptor signaling pathway GO:0007166 325 0.793
cellular aromatic compound metabolic process GO:0006725 295 0.789
Human Zebrafish Mouse Worm Fly
vasculogenesis GO:0001570 41 0.777
neuron fate commitment GO:0048663 26 0.776
Mouse Worm Fly
neural crest cell migration GO:0001755 42 0.771
pancreatic a cell development GO:0003322 2 0.767
forebrain generation of neurons GO:0021872 14 0.762
regulation of cellular metabolic process GO:0031323 320 0.753
Human Zebrafish Mouse Worm Fly
neuron fate specification GO:0048665 20 0.751
Worm
regulation of nucleic acid templated transcription GO:1903506 213 0.749
Human Zebrafish Mouse Worm Fly
nucleic acid metabolic process GO:0090304 244 0.745
Human Zebrafish Mouse Worm Fly
neural tube patterning GO:0021532 33 0.744
central nervous system neuron differentiation GO:0021953 74 0.736
positive regulation of cellular process GO:0048522 201 0.733
Human Zebrafish Mouse Worm Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.728
Human Zebrafish Mouse Worm Fly
pancreatic d cell differentiation GO:0003311 2 0.724
hindbrain development GO:0030902 91 0.719
neural retina development GO:0003407 49 0.718
embryo development ending in birth or egg hatching GO:0009792 271 0.706
retinal pigment epithelium development GO:0003406 8 0.703
regulation of rna biosynthetic process GO:2001141 213 0.689
Human Zebrafish Mouse Worm Fly
forebrain midbrain boundary formation GO:0021905 1 0.688
cellular macromolecule metabolic process GO:0044260 391 0.685
Human Zebrafish Mouse Worm Fly
embryonic organ development GO:0048568 381 0.676
Mouse
ventral spinal cord development GO:0021517 35 0.667
blood vessel morphogenesis GO:0048514 216 0.664
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.650
gastrulation GO:0007369 208 0.644
Mouse
regulation of metabolic process GO:0019222 359 0.642
Human Zebrafish Mouse Worm Fly
abducens nucleus development GO:0021742 2 0.627
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.625
Human Zebrafish Mouse Worm Fly
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.623
signal transduction GO:0007165 455 0.616
stem cell proliferation GO:0072089 4 0.612
positive regulation of neuron migration GO:2001224 2 0.596
camera type eye photoreceptor cell differentiation GO:0060219 19 0.593
mesenchymal cell differentiation GO:0048762 87 0.593
central nervous system myelin formation GO:0032289 1 0.574
anterior posterior pattern specification GO:0009952 152 0.573
rna biosynthetic process GO:0032774 181 0.572
Human Zebrafish Mouse Worm Fly
midbrain hindbrain boundary development GO:0030917 23 0.565
negative regulation of translational initiation GO:0045947 1 0.564
regulation of rna metabolic process GO:0051252 224 0.562
Human Zebrafish Mouse Worm Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.554
Fly
embryonic heart tube development GO:0035050 133 0.548
cellular nitrogen compound metabolic process GO:0034641 290 0.545
Human Zebrafish Mouse Worm Fly
heterocycle metabolic process GO:0046483 290 0.543
Human Zebrafish Mouse Worm Fly
cell differentiation in spinal cord GO:0021515 40 0.537
neural crest cell development GO:0014032 62 0.536
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.529
Human Zebrafish Mouse Worm Fly
retinal cell programmed cell death GO:0046666 2 0.521
Zebrafish
nitrogen compound metabolic process GO:0006807 319 0.520
Human Zebrafish Mouse Worm Fly
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.515
organic substance biosynthetic process GO:1901576 289 0.511
Human Zebrafish Mouse Worm Fly
epithelial cell differentiation GO:0030855 116 0.509
glial cell development GO:0021782 20 0.507
epidermal cell fate specification GO:0009957 4 0.503
regulation of nervous system development GO:0051960 90 0.500
Fly
positive regulation of stem cell proliferation GO:2000648 1 0.499
gliogenesis GO:0042063 45 0.491
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.486
Human Mouse Worm Fly
morphogenesis of an epithelium GO:0002009 333 0.485
spinal cord development GO:0021510 46 0.485
positive regulation of rna metabolic process GO:0051254 59 0.482
Human Zebrafish Mouse Worm Fly
regulation of cellular biosynthetic process GO:0031326 245 0.478
Human Zebrafish Mouse Worm Fly
regulation of cell differentiation GO:0045595 142 0.455
Zebrafish Fly
neuron projection development GO:0031175 180 0.450
Human Fly
forebrain development GO:0030900 96 0.437
Mouse
embryonic eye morphogenesis GO:0048048 30 0.433
biosynthetic process GO:0009058 294 0.432
Human Zebrafish Mouse Worm Fly
regulation of stem cell proliferation GO:0072091 2 0.426
forebrain neuron differentiation GO:0021879 14 0.418
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.418
Fly
mesenchymal cell development GO:0014031 78 0.413
ear development GO:0043583 127 0.408
Mouse
rna metabolic process GO:0016070 219 0.408
Human Zebrafish Mouse Worm Fly
regulation of neural precursor cell proliferation GO:2000177 3 0.407
regulation of transcription involved in cell fate commitment GO:0060850 1 0.404
regulation of signaling GO:0023051 235 0.403
cell projection morphogenesis GO:0048858 244 0.401
Human Fly
limb bud formation GO:0060174 2 0.398
glial cell fate commitment GO:0021781 6 0.394
glial cell fate specification GO:0021780 4 0.388
positive regulation of rna biosynthetic process GO:1902680 57 0.385
Human Zebrafish Mouse Worm Fly
negative regulation of cellular process GO:0048523 283 0.377
Zebrafish Fly
spinal cord motor neuron differentiation GO:0021522 26 0.368
auditory receptor cell fate commitment GO:0009912 4 0.363
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.353
Human Zebrafish Mouse Worm Fly
positive regulation of neural precursor cell proliferation GO:2000179 1 0.349
system process GO:0003008 185 0.349
Zebrafish Worm
response to light stimulus GO:0009416 46 0.345
neural crest cell differentiation GO:0014033 72 0.341
cellular component morphogenesis GO:0032989 336 0.339
Human Fly
hindbrain morphogenesis GO:0021575 22 0.339
regulation of nitrogen compound metabolic process GO:0051171 251 0.333
Human Zebrafish Mouse Worm Fly
cellular component movement GO:0006928 335 0.332
Human
glial cell differentiation GO:0010001 42 0.331
negative regulation of nervous system development GO:0051961 22 0.331
peripheral nervous system neuron differentiation GO:0048934 28 0.331
morphogenesis of embryonic epithelium GO:0016331 30 0.325
blood vessel development GO:0001568 246 0.323
regulation of neurogenesis GO:0050767 87 0.323
Fly
neuroblast proliferation GO:0007405 2 0.319
cellular response to prostaglandin stimulus GO:0071379 3 0.310
inner ear receptor cell fate commitment GO:0060120 4 0.307
epidermis development GO:0008544 48 0.306
segmentation GO:0035282 97 0.299
Mouse Fly
iris morphogenesis GO:0061072 1 0.297
lens morphogenesis in camera type eye GO:0002089 7 0.297
cellular nitrogen compound biosynthetic process GO:0044271 218 0.296
Human Zebrafish Mouse Worm Fly
gene expression GO:0010467 252 0.295
Human Zebrafish Mouse Worm Fly
melanocyte differentiation GO:0030318 26 0.293
positive regulation of cell fate specification GO:0042660 1 0.284
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.283
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.281
Human Zebrafish Mouse Worm Fly
pigment granule organization GO:0048753 4 0.277
mammillary body development GO:0021767 4 0.275
cranial ganglion development GO:0061550 3 0.274
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.272
Fly
negative regulation of cellular biosynthetic process GO:0031327 55 0.271
Fly
neuroblast fate determination GO:0007400 1 0.268
positive regulation of gene expression GO:0010628 71 0.265
Human Zebrafish Mouse Worm Fly
somite development GO:0061053 96 0.257
Mouse
positive regulation of cellular biosynthetic process GO:0031328 68 0.253
Human Zebrafish Mouse Worm Fly
negative regulation of gene expression GO:0010629 65 0.249
Fly
vasculature development GO:0001944 278 0.247
convergent extension GO:0060026 118 0.247
digestive tract development GO:0048565 265 0.246
Mouse
stem cell differentiation GO:0048863 117 0.245
pancreas development GO:0031016 84 0.243
macromolecule biosynthetic process GO:0009059 227 0.243
Human Zebrafish Mouse Worm Fly
epidermal cell differentiation GO:0009913 36 0.241
axon ensheathment GO:0008366 18 0.240
heart development GO:0007507 313 0.238
photoreceptor cell fate specification GO:0043704 1 0.236
digestive system development GO:0055123 289 0.235
Mouse
mesoderm development GO:0007498 88 0.234
regulation of neuron migration GO:2001222 2 0.233
cell morphogenesis involved in differentiation GO:0000904 195 0.231
Human Fly
negative regulation of rna metabolic process GO:0051253 48 0.231
Fly
heart looping GO:0001947 94 0.230
enzyme linked receptor protein signaling pathway GO:0007167 106 0.230
morphogenesis of an epithelial sheet GO:0002011 49 0.221
central nervous system myelination GO:0022010 2 0.209
retinal cone cell development GO:0046549 8 0.207
mechanoreceptor differentiation GO:0042490 37 0.206
atrioventricular valve formation GO:0003190 3 0.202
negative regulation of retinal cell programmed cell death GO:0046671 2 0.201
Zebrafish
negative regulation of cell development GO:0010721 26 0.201
Zebrafish
somite specification GO:0001757 12 0.200
determination of bilateral symmetry GO:0009855 204 0.200
anterior commissure morphogenesis GO:0021960 3 0.195
ectodermal placode development GO:0071696 37 0.195
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.194
Fly
regulation of epithelial cell proliferation GO:0050678 3 0.193
regulation of multicellular organismal process GO:0051239 277 0.192
Zebrafish Mouse Fly
aorta development GO:0035904 4 0.192
embryonic epithelial tube formation GO:0001838 17 0.191
negative regulation of neurogenesis GO:0050768 20 0.190
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.189
Fly
optic cup morphogenesis involved in camera type eye development GO:0002072 7 0.188
pituitary gland development GO:0021983 16 0.187
neural tube formation GO:0001841 16 0.187
positive regulation of transcription dna templated GO:0045893 57 0.183
Human Zebrafish Mouse Worm Fly
positive regulation of cell fate commitment GO:0010455 1 0.176
dorsal ventral pattern formation GO:0009953 125 0.176
Mouse
neuron projection guidance GO:0097485 86 0.175
Human
cardiac cell fate commitment GO:0060911 1 0.175
neuroblast differentiation GO:0014016 1 0.175
cell cycle GO:0007049 93 0.172
regulation of multicellular organismal development GO:2000026 223 0.172
Zebrafish Mouse Fly
glial cell migration GO:0008347 3 0.172
inner ear development GO:0048839 126 0.171
Mouse
ventral spinal cord interneuron fate commitment GO:0060579 3 0.170
retinal cone cell differentiation GO:0042670 12 0.168
determination of left right symmetry GO:0007368 179 0.161
positive regulation of macromolecule metabolic process GO:0010604 93 0.160
Human Zebrafish Mouse Worm Fly
cilium organization GO:0044782 71 0.159
cellular component assembly involved in morphogenesis GO:0010927 107 0.157
muscle structure development GO:0061061 196 0.157
skin development GO:0043588 54 0.155
inner ear receptor cell differentiation GO:0060113 29 0.154
digestive tract morphogenesis GO:0048546 231 0.154
Mouse
embryonic pattern specification GO:0009880 44 0.152
Mouse
angiogenesis GO:0001525 158 0.148
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.144
Human Fly
central nervous system neuron development GO:0021954 29 0.143
developmental growth involved in morphogenesis GO:0060560 86 0.143
lens development in camera type eye GO:0002088 22 0.141
primary neural tube formation GO:0014020 1 0.138
inner ear morphogenesis GO:0042472 63 0.138
Mouse
positive regulation of nervous system development GO:0051962 25 0.137
Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.136
Human Mouse Worm Fly
neuron fate determination GO:0048664 2 0.135
Mouse
regulation of cell development GO:0060284 100 0.134
Zebrafish Fly
multi organism process GO:0051704 134 0.133
sympathetic nervous system development GO:0048485 3 0.132
auditory receptor cell differentiation GO:0042491 15 0.132
cellular response to fatty acid GO:0071398 3 0.130
neural crest formation GO:0014029 14 0.129
pharyngeal muscle development GO:0043282 4 0.128
neuromast mantle cell differentiation GO:0048888 1 0.127
embryonic heart tube morphogenesis GO:0003143 108 0.126
response to chemical GO:0042221 320 0.126
cell fate commitment involved in pattern specification GO:0060581 6 0.125
neuroepithelial cell differentiation GO:0060563 26 0.125
specification of symmetry GO:0009799 204 0.125
axon guidance GO:0007411 86 0.124
Human
maintenance of location GO:0051235 4 0.124
determination of pancreatic left right asymmetry GO:0035469 11 0.124
axon ensheathment in central nervous system GO:0032291 2 0.124
lateral line ganglion development GO:0048890 2 0.123
olfactory lobe development GO:0021988 4 0.123
neuroblast fate commitment GO:0014017 1 0.122
larval development GO:0002164 2 0.120
glial cell fate determination GO:0007403 1 0.119
artery development GO:0060840 22 0.119
cell part morphogenesis GO:0032990 246 0.118
Human Fly
formation of primary germ layer GO:0001704 62 0.117
positive regulation of biological process GO:0048518 253 0.115
Human Zebrafish Mouse Worm Fly
stem cell fate determination GO:0048867 1 0.114
mesenchyme development GO:0060485 127 0.112
cell migration GO:0016477 237 0.112
extraocular skeletal muscle development GO:0002074 3 0.109
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.106
epithelial tube formation GO:0072175 19 0.106
single organism organelle organization GO:1902589 199 0.105
ectodermal placode formation GO:0060788 26 0.105
negative regulation of biosynthetic process GO:0009890 55 0.105
Fly
myeloid cell differentiation GO:0030099 86 0.104
localization of cell GO:0051674 244 0.104
organelle organization GO:0006996 227 0.103
Fly
negative regulation of transcription dna templated GO:0045892 45 0.103
Fly
peripheral nervous system neuron development GO:0048935 22 0.103
olfactory bulb development GO:0021772 4 0.102
endocrine pancreas development GO:0031018 27 0.100
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.098
Human Zebrafish Mouse Worm Fly
ectodermal placode morphogenesis GO:0071697 32 0.097
sensory epithelium regeneration GO:0070654 14 0.097
axonogenesis GO:0007409 152 0.096
Human
positive regulation of transport GO:0051050 2 0.094
gland development GO:0048732 143 0.093
muscle tissue development GO:0060537 110 0.090
pigment cell differentiation GO:0050931 38 0.089
response to alcohol GO:0097305 14 0.089
negative regulation of biological process GO:0048519 304 0.088
Zebrafish Fly
regulation of developmental process GO:0050793 247 0.088
Zebrafish Mouse Fly
hematopoietic or lymphoid organ development GO:0048534 191 0.088
artery morphogenesis GO:0048844 14 0.087
multicellular organismal water homeostasis GO:0050891 1 0.086
negative regulation of cell differentiation GO:0045596 46 0.085
Zebrafish
nucleocytoplasmic transport GO:0006913 4 0.085
autonomic nervous system development GO:0048483 19 0.084
response to axon injury GO:0048678 14 0.084
epithelial cell fate commitment GO:0072148 11 0.084
pancreatic d cell development GO:0003324 1 0.084
enteroendocrine cell differentiation GO:0035883 9 0.083
cell motility GO:0048870 244 0.082
heart formation GO:0060914 13 0.082
cell proliferation in hindbrain GO:0021534 4 0.081
negative regulation of neuron differentiation GO:0045665 10 0.080
segment specification GO:0007379 12 0.077
lipid storage GO:0019915 1 0.077
gabaergic neuron differentiation GO:0097154 2 0.077
regulation of response to stimulus GO:0048583 269 0.077
water homeostasis GO:0030104 4 0.076
transcription from rna polymerase ii promoter GO:0006366 80 0.075
Human Mouse Worm Fly
pronephric glomerulus development GO:0039021 13 0.075
transmission of nerve impulse GO:0019226 19 0.075
response to external stimulus GO:0009605 264 0.075
Human
cerebellar cortex development GO:0021695 5 0.075
negative regulation of macromolecule metabolic process GO:0010605 76 0.075
Fly
pronephros development GO:0048793 69 0.075
positive regulation of metabolic process GO:0009893 108 0.075
Human Zebrafish Mouse Worm Fly
endoderm development GO:0007492 49 0.074
Mouse
stem cell fate commitment GO:0048865 1 0.073
positive regulation of axon guidance GO:1902669 1 0.073
stem cell development GO:0048864 82 0.073
nuclear transport GO:0051169 4 0.073
axon extension involved in axon guidance GO:0048846 10 0.073
atrial ventricular junction remodeling GO:0003294 2 0.072
positive regulation of cellular metabolic process GO:0031325 94 0.072
Human Zebrafish Mouse Worm Fly
fourth ventricle development GO:0021592 8 0.071
cellular pigmentation GO:0033059 30 0.071
limbic system development GO:0021761 16 0.071
notch signaling pathway GO:0007219 35 0.070
dopaminergic neuron differentiation GO:0071542 14 0.070
determination of heart left right asymmetry GO:0061371 117 0.070
posterior lateral line neuromast mantle cell differentiation GO:0048924 1 0.069
adenohypophysis development GO:0021984 15 0.068
facial nucleus development GO:0021754 7 0.067
aging GO:0007568 2 0.067
hemopoiesis GO:0030097 183 0.067
somatic motor neuron differentiation GO:0021523 5 0.066
aorta morphogenesis GO:0035909 3 0.066
chemosensory behavior GO:0007635 1 0.065
Worm
forebrain cell migration GO:0021885 1 0.065
nerve development GO:0021675 45 0.064
negative regulation of wnt signaling pathway GO:0030178 30 0.063
auditory receptor cell development GO:0060117 8 0.063
negative regulation of rna biosynthetic process GO:1902679 45 0.063
Fly
negative regulation of cellular metabolic process GO:0031324 77 0.063
Fly
axis specification GO:0009798 43 0.062
Mouse
mesoderm morphogenesis GO:0048332 51 0.062
closure of optic fissure GO:0061386 6 0.062
retinal ganglion cell axon guidance GO:0031290 35 0.062
embryonic camera type eye formation GO:0060900 10 0.062
hair cell differentiation GO:0035315 32 0.061
post embryonic morphogenesis GO:0009886 4 0.060
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.060
enteric nervous system development GO:0048484 12 0.060
regulation of canonical wnt signaling pathway GO:0060828 34 0.060
peripheral nervous system neuron axonogenesis GO:0048936 13 0.059
neuron neuron synaptic transmission GO:0007270 1 0.059
negative regulation of epithelial cell proliferation GO:0050680 1 0.058
lymphatic endothelial cell differentiation GO:0060836 1 0.058
pigmentation GO:0043473 85 0.058
negative regulation of gliogenesis GO:0014014 1 0.057
auditory receptor cell fate determination GO:0042668 2 0.057
cell cell signaling GO:0007267 52 0.057
oligodendrocyte development GO:0014003 7 0.057
myelination GO:0042552 18 0.057
formation of anatomical boundary GO:0048859 14 0.056
homeostatic process GO:0042592 142 0.056
peripheral nervous system development GO:0007422 55 0.056
muscle fiber development GO:0048747 52 0.055
embryonic organ morphogenesis GO:0048562 274 0.055
Mouse
oligodendrocyte cell fate commitment GO:0021779 5 0.054
visual perception GO:0007601 17 0.054
Zebrafish
protein targeting to nucleus GO:0044744 3 0.054
otic placode formation GO:0043049 23 0.053
positive regulation of neurogenesis GO:0050769 24 0.053
Fly
chemotaxis GO:0006935 104 0.053
Human
endodermal cell fate determination GO:0007493 2 0.052
canonical wnt signaling pathway GO:0060070 48 0.052
rho protein signal transduction GO:0007266 5 0.051
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.051
neural precursor cell proliferation GO:0061351 20 0.051
heart process GO:0003015 71 0.051
cell migration involved in gastrulation GO:0042074 79 0.050
pharyngeal system development GO:0060037 18 0.050
negative regulation of nucleic acid templated transcription GO:1903507 45 0.050
Fly
epithelial cell development GO:0002064 42 0.049
establishment of localization GO:0051234 244 0.049
regulation of binding GO:0051098 3 0.048
myeloid cell homeostasis GO:0002262 56 0.048
negative regulation of leukocyte differentiation GO:1902106 1 0.048
regulation of biological quality GO:0065008 263 0.048
striated muscle tissue development GO:0014706 110 0.048
glandular epithelial cell differentiation GO:0002067 9 0.048
spinal cord motor neuron cell fate specification GO:0021520 8 0.047
proepicardium development GO:0003342 4 0.047
pericardium morphogenesis GO:0003344 1 0.047
retinal rod cell development GO:0046548 4 0.046
immune system process GO:0002376 241 0.045
regulation of cell motility GO:2000145 46 0.045
cell proliferation in midbrain GO:0033278 4 0.045
negative regulation of protein phosphorylation GO:0001933 4 0.045
otic vesicle development GO:0071599 42 0.044
positive regulation of endothelial cell differentiation GO:0045603 2 0.044
organ formation GO:0048645 17 0.044
cardiac muscle tissue development GO:0048738 48 0.044
anterior posterior axis specification GO:0009948 20 0.044
Mouse
ensheathment of neurons GO:0007272 18 0.043
regulation of neuron differentiation GO:0045664 56 0.043
Fly
cell proliferation involved in heart morphogenesis GO:0061323 2 0.042
regulation of molecular function GO:0065009 70 0.042
developmental maturation GO:0021700 34 0.042
optomotor response GO:0071632 1 0.041
guanosine containing compound catabolic process GO:1901069 2 0.041
positive regulation of biosynthetic process GO:0009891 68 0.041
Human Zebrafish Mouse Worm Fly
cell differentiation in hindbrain GO:0021533 5 0.041
mesoderm formation GO:0001707 43 0.041
dorsal ventral axis specification GO:0009950 14 0.040
protein modification process GO:0036211 100 0.040
endocardium formation GO:0060214 1 0.040
wnt signaling pathway GO:0016055 80 0.039
extracellular fibril organization GO:0043206 1 0.039
immune system development GO:0002520 191 0.039
heart valve formation GO:0003188 4 0.038
regulation of axon extension GO:0030516 24 0.038
positive regulation of cell development GO:0010720 25 0.038
Fly
cell projection assembly GO:0030031 64 0.038
protein import into nucleus GO:0006606 3 0.038
gastrulation with mouth forming second GO:0001702 44 0.038
Mouse
endothelial cell fate commitment GO:0060839 3 0.038
sensory perception of light stimulus GO:0050953 19 0.037
Zebrafish
regulation of nucleoside metabolic process GO:0009118 2 0.037
cardiocyte differentiation GO:0035051 44 0.037
intracellular estrogen receptor signaling pathway GO:0030520 3 0.037
lymphatic endothelial cell fate commitment GO:0060838 1 0.037
programmed cell death GO:0012501 119 0.037
Zebrafish
bmp signaling pathway GO:0030509 52 0.036
gtp metabolic process GO:0046039 4 0.036
cellular protein metabolic process GO:0044267 129 0.036
epithelium regeneration GO:1990399 14 0.036
tube closure GO:0060606 1 0.036
pectoral fin morphogenesis GO:0035138 29 0.035
phosphorus metabolic process GO:0006793 109 0.035
cilium assembly GO:0042384 58 0.035
single organism nuclear import GO:1902593 3 0.035
ear morphogenesis GO:0042471 64 0.035
Mouse
circadian regulation of gene expression GO:0032922 8 0.035
Zebrafish
negative regulation of signaling GO:0023057 96 0.034
gtp catabolic process GO:0006184 2 0.034
somatic stem cell maintenance GO:0035019 1 0.034
guanosine containing compound metabolic process GO:1901068 4 0.034
positive regulation of axon extension involved in axon guidance GO:0048842 1 0.034
type b pancreatic cell differentiation GO:0003309 8 0.034
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.034
cilium morphogenesis GO:0060271 85 0.033
cell fate specification GO:0001708 68 0.033
Mouse Worm
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.033
heart contraction GO:0060047 71 0.033
regulation of intracellular protein transport GO:0033157 3 0.032
detection of abiotic stimulus GO:0009582 24 0.032
regulation of signal transduction GO:0009966 225 0.032
intermediate mesoderm development GO:0048389 2 0.032
dorsal aorta morphogenesis GO:0035912 3 0.032
multicellular organismal signaling GO:0035637 22 0.031
stem cell division GO:0017145 1 0.031
peptide transport GO:0015833 1 0.031
dorsal aorta development GO:0035907 4 0.031
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.031
positive regulation of notch signaling pathway GO:0045747 3 0.030
endochondral bone morphogenesis GO:0060350 8 0.030
astrocyte differentiation GO:0048708 1 0.030
oligodendrocyte differentiation GO:0048709 23 0.029
circulatory system process GO:0003013 87 0.029
spinal cord radial glial cell differentiation GO:0021531 2 0.029
cell projection organization GO:0030030 284 0.029
Human Fly

otx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.678
Human
disease of anatomical entity DOID:7 0 0.678
Human
eye and adnexa disease DOID:1492 0 0.678
Human
nervous system disease DOID:863 0 0.678
Human
eye disease DOID:5614 0 0.154
Human
retinal disease DOID:5679 0 0.063
retinal degeneration DOID:8466 0 0.063
physical disorder DOID:0080015 0 0.035
congenital nervous system abnormality DOID:2490 0 0.035