Danio rerio

13 known processes

paf1

paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)

(Aliases: wu:fb80a09,paf1l,im:6906070)

paf1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nitrogen compound metabolic process GO:0006807 319 0.542
cellular aromatic compound metabolic process GO:0006725 295 0.521
negative regulation of biological process GO:0048519 304 0.435
cellular nitrogen compound metabolic process GO:0034641 290 0.423
larval development GO:0002164 2 0.354
regulation of nitrogen compound metabolic process GO:0051171 251 0.351
gene expression GO:0010467 252 0.350
cellular macromolecule metabolic process GO:0044260 391 0.313
nucleic acid metabolic process GO:0090304 244 0.307
regulation of gene expression GO:0010468 265 0.282
signal transduction GO:0007165 455 0.257
nucleobase containing compound metabolic process GO:0006139 274 0.244
organic cyclic compound metabolic process GO:1901360 301 0.238
regulation of macromolecule metabolic process GO:0060255 317 0.234
aging GO:0007568 2 0.231
regulation of metabolic process GO:0019222 359 0.223
regulation of primary metabolic process GO:0080090 311 0.213
negative regulation of cellular process GO:0048523 283 0.206
organic cyclic compound biosynthetic process GO:1901362 223 0.204
positive regulation of biological process GO:0048518 253 0.187
cell motility GO:0048870 244 0.186
cellular component movement GO:0006928 335 0.184
positive regulation of rna metabolic process GO:0051254 59 0.179
locomotion GO:0040011 313 0.170
positive regulation of cellular process GO:0048522 201 0.154
negative regulation of gene expression GO:0010629 65 0.154
regulation of transcription dna templated GO:0006355 213 0.151
macromolecule biosynthetic process GO:0009059 227 0.144
embryonic organ development GO:0048568 381 0.143
nucleobase containing compound biosynthetic process GO:0034654 205 0.139
rna biosynthetic process GO:0032774 181 0.137
gene silencing GO:0016458 4 0.128
cell migration GO:0016477 237 0.128
embryo development ending in birth or egg hatching GO:0009792 271 0.128
response to stress GO:0006950 263 0.125
aromatic compound biosynthetic process GO:0019438 217 0.125
heterocycle metabolic process GO:0046483 290 0.119
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.119
heterocycle biosynthetic process GO:0018130 215 0.118
regulation of developmental process GO:0050793 247 0.116
cellular biosynthetic process GO:0044249 286 0.113
regulation of meiotic cell cycle GO:0051445 1 0.110
nucleic acid templated transcription GO:0097659 181 0.109
meiotic nuclear division GO:0007126 4 0.109
regulation of nucleic acid templated transcription GO:1903506 213 0.107
regulation of gene expression epigenetic GO:0040029 11 0.107
regulation of cellular biosynthetic process GO:0031326 245 0.100
rna metabolic process GO:0016070 219 0.097
transcription dna templated GO:0006351 181 0.094
cellular macromolecule biosynthetic process GO:0034645 224 0.093
regulation of cell cycle GO:0051726 52 0.091
biosynthetic process GO:0009058 294 0.091
positive regulation of cellular metabolic process GO:0031325 94 0.090
cell morphogenesis GO:0000902 289 0.090
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.087
regulation of macromolecule biosynthetic process GO:0010556 225 0.086
cellular component morphogenesis GO:0032989 336 0.085
single organism metabolic process GO:0044710 217 0.084
regulation of cell communication GO:0010646 232 0.083
negative regulation of dna replication GO:0008156 2 0.081
multicellular organism growth GO:0035264 4 0.081
fertilization GO:0009566 3 0.080
regulation of rna metabolic process GO:0051252 224 0.080
negative regulation of metabolic process GO:0009892 86 0.079
negative regulation of cellular biosynthetic process GO:0031327 55 0.079
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.079
organelle organization GO:0006996 227 0.077
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.076
cellular protein catabolic process GO:0044257 4 0.076
negative regulation of biosynthetic process GO:0009890 55 0.075
embryonic organ morphogenesis GO:0048562 274 0.073
cellular response to stress GO:0033554 62 0.071
negative regulation of transcription dna templated GO:0045892 45 0.069
mitotic cell cycle GO:0000278 64 0.068
regulation of biosynthetic process GO:0009889 250 0.065
localization of cell GO:0051674 244 0.065
generation of neurons GO:0048699 385 0.064
regulation of signaling GO:0023051 235 0.064
regulation of rna biosynthetic process GO:2001141 213 0.064
single organism organelle organization GO:1902589 199 0.062
neuron development GO:0048666 262 0.062
organism emergence from protective structure GO:0071684 4 0.062
growth GO:0040007 174 0.062
response to drug GO:0042493 3 0.060
protein metabolic process GO:0019538 183 0.059
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.058
enzyme linked receptor protein signaling pathway GO:0007167 106 0.057
regulation of cell shape GO:0008360 1 0.056
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.056
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.056
cell projection organization GO:0030030 284 0.055
establishment of protein localization to organelle GO:0072594 4 0.055
negative regulation of macromolecule metabolic process GO:0010605 76 0.053
behavior GO:0007610 74 0.053
regulation of synapse organization GO:0050807 3 0.053
histone h3 k4 methylation GO:0051568 2 0.052
negative regulation of cell communication GO:0010648 96 0.052
apoptotic process GO:0006915 116 0.051
positive regulation of nucleic acid templated transcription GO:1903508 57 0.051
adult behavior GO:0030534 2 0.050
regulation of multicellular organismal development GO:2000026 223 0.050
macromolecular complex subunit organization GO:0043933 74 0.050
regulation of response to stimulus GO:0048583 269 0.049
mitotic dna integrity checkpoint GO:0044774 4 0.049
response to chemical GO:0042221 320 0.049
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.049
internal protein amino acid acetylation GO:0006475 2 0.048
synaptic growth at neuromuscular junction GO:0051124 2 0.048
regulation of cell differentiation GO:0045595 142 0.048
small molecule metabolic process GO:0044281 77 0.047
negative regulation of cellular metabolic process GO:0031324 77 0.047
meiotic chromosome segregation GO:0045132 3 0.046
regulation of cellular metabolic process GO:0031323 320 0.045
organonitrogen compound metabolic process GO:1901564 74 0.044
peptidyl lysine methylation GO:0018022 3 0.044
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.043
vasculature development GO:0001944 278 0.043
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.043
stem cell differentiation GO:0048863 117 0.043
mitotic g2 dna damage checkpoint GO:0007095 3 0.043
double strand break repair GO:0006302 3 0.043
rna 3 end processing GO:0031123 2 0.042
spliceosomal snrnp assembly GO:0000387 2 0.042
regulation of binding GO:0051098 3 0.042
multi organism process GO:0051704 134 0.041
cellular nitrogen compound biosynthetic process GO:0044271 218 0.040
response to external stimulus GO:0009605 264 0.040
cytoskeleton organization GO:0007010 96 0.040
single fertilization GO:0007338 3 0.039
cell cycle GO:0007049 93 0.039
regulation of signal transduction GO:0009966 225 0.039
modification dependent macromolecule catabolic process GO:0043632 3 0.039
establishment of localization GO:0051234 244 0.038
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.038
mitotic g2 m transition checkpoint GO:0044818 3 0.038
macromolecule modification GO:0043412 111 0.038
protein acetylation GO:0006473 2 0.037
single organism localization GO:1902578 225 0.037
protein modification process GO:0036211 100 0.037
cellular component biogenesis GO:0044085 178 0.036
negative regulation of signal transduction GO:0009968 94 0.036
positive regulation of transport GO:0051050 2 0.035
tube morphogenesis GO:0035239 349 0.035
phosphorus metabolic process GO:0006793 109 0.034
peptidyl lysine acetylation GO:0018394 2 0.034
chromatin modification GO:0016568 21 0.034
neuron differentiation GO:0030182 353 0.033
positive regulation of transcription dna templated GO:0045893 57 0.033
female sex differentiation GO:0046660 4 0.033
positive regulation of cellular biosynthetic process GO:0031328 68 0.033
positive regulation of metabolic process GO:0009893 108 0.032
phagocytosis GO:0006909 3 0.032
development of primary female sexual characteristics GO:0046545 4 0.032
regulation of cellular component organization GO:0051128 86 0.031
death GO:0016265 121 0.031
regulation of biological quality GO:0065008 263 0.031
ras protein signal transduction GO:0007265 7 0.031
regulation of multicellular organismal process GO:0051239 277 0.031
internal peptidyl lysine acetylation GO:0018393 2 0.031
positive regulation of rna biosynthetic process GO:1902680 57 0.030
regulation of dna replication GO:0006275 3 0.030
cellular component assembly GO:0022607 170 0.030
intracellular signal transduction GO:0035556 85 0.030
negative regulation of cell cycle GO:0045786 14 0.030
stem cell proliferation GO:0072089 4 0.030
positive regulation of macromolecule metabolic process GO:0010604 93 0.030
immune system process GO:0002376 241 0.029
regulation of circadian rhythm GO:0042752 4 0.029
cellular localization GO:0051641 97 0.029
negative regulation of signaling GO:0023057 96 0.029
homeostatic process GO:0042592 142 0.029
negative regulation of ras protein signal transduction GO:0046580 1 0.029
protein localization to nucleus GO:0034504 3 0.028
small gtpase mediated signal transduction GO:0007264 8 0.028
regulation of programmed cell death GO:0043067 101 0.028
cell morphogenesis involved in differentiation GO:0000904 195 0.027
regulation of multicellular organism growth GO:0040014 4 0.027
morphogenesis of an epithelium GO:0002009 333 0.027
response to external biotic stimulus GO:0043207 97 0.027
maintenance of location GO:0051235 4 0.027
regionalization GO:0003002 274 0.027
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.027
nuclear import GO:0051170 3 0.027
positive regulation of gene expression GO:0010628 71 0.027
anterior posterior pattern specification GO:0009952 152 0.027
regulation of cell death GO:0010941 103 0.027
proteasomal protein catabolic process GO:0010498 2 0.026
negative regulation of rna metabolic process GO:0051253 48 0.026
negative regulation of dna metabolic process GO:0051053 4 0.026
organic acid metabolic process GO:0006082 31 0.026
programmed cell death GO:0012501 119 0.026
nuclear transport GO:0051169 4 0.026
regulation of apoptotic process GO:0042981 98 0.026
regulation of cellular amine metabolic process GO:0033238 0 0.026
g2 dna damage checkpoint GO:0031572 3 0.026
cellular response to dna damage stimulus GO:0006974 24 0.025
triglyceride homeostasis GO:0070328 2 0.025
cilium assembly GO:0042384 58 0.025
cell projection morphogenesis GO:0048858 244 0.025
segmentation GO:0035282 97 0.025
embryonic limb morphogenesis GO:0030326 2 0.025
regulation of synapse assembly GO:0051963 3 0.025
blood vessel development GO:0001568 246 0.025
neuron projection development GO:0031175 180 0.025
liver development GO:0001889 96 0.025
heart development GO:0007507 313 0.024
multi organism cellular process GO:0044764 2 0.024
regulation of cell proliferation GO:0042127 37 0.024
negative regulation of response to stimulus GO:0048585 104 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.024
positive regulation of cellular catabolic process GO:0031331 3 0.024
central nervous system development GO:0007417 387 0.024
epithelial cell differentiation GO:0030855 116 0.024
mitotic dna damage checkpoint GO:0044773 4 0.024
response to endogenous stimulus GO:0009719 83 0.024
chordate embryonic development GO:0043009 271 0.023
amine metabolic process GO:0009308 2 0.023
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.023
cytokinesis GO:0000910 3 0.023
transcription from rna polymerase ii promoter GO:0006366 80 0.023
developmental growth GO:0048589 166 0.023
positive regulation of cellular component biogenesis GO:0044089 3 0.022
rna processing GO:0006396 25 0.022
ubiquitin dependent protein catabolic process GO:0006511 3 0.022
negative regulation of multicellular organismal process GO:0051241 69 0.022
dna metabolic process GO:0006259 27 0.022
cell part morphogenesis GO:0032990 246 0.022
blood vessel morphogenesis GO:0048514 216 0.022
cellular carbohydrate metabolic process GO:0044262 4 0.022
microtubule cytoskeleton organization GO:0000226 33 0.021
response to abiotic stimulus GO:0009628 122 0.021
stem cell maintenance GO:0019827 4 0.021
oocyte anterior posterior axis specification GO:0007314 4 0.021
single organism reproductive process GO:0044702 40 0.021
regulation of mrna processing GO:0050684 3 0.021
regulation of nervous system development GO:0051960 90 0.021
cellular amine metabolic process GO:0044106 2 0.021
nucleocytoplasmic transport GO:0006913 4 0.021
negative regulation of nucleic acid templated transcription GO:1903507 45 0.020
female gonad development GO:0008585 4 0.020
protein targeting to nucleus GO:0044744 3 0.020
cell proliferation GO:0008283 80 0.020
cellular protein modification process GO:0006464 100 0.020
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.020
hemopoiesis GO:0030097 183 0.020
rna localization GO:0006403 4 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
protein complex subunit organization GO:0071822 46 0.020
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
protein stabilization GO:0050821 2 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.019
cellular ketone metabolic process GO:0042180 11 0.019
negative regulation of cell death GO:0060548 60 0.019
skin development GO:0043588 54 0.019
regulation of cytokine production GO:0001817 3 0.019
negative regulation of developmental process GO:0051093 65 0.019
microtubule based process GO:0007017 60 0.019
positive regulation of gliogenesis GO:0014015 2 0.019
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.019
regulation of cell cycle process GO:0010564 20 0.018
epidermis development GO:0008544 48 0.018
cellular response to radiation GO:0071478 4 0.018
angiogenesis GO:0001525 158 0.018
carboxylic acid metabolic process GO:0019752 22 0.018
multicellular organism reproduction GO:0032504 35 0.018
gland development GO:0048732 143 0.018
cellular component assembly involved in morphogenesis GO:0010927 107 0.018
mrna processing GO:0006397 14 0.018
positive regulation of synapse assembly GO:0051965 1 0.018
single organism transport GO:0044765 206 0.018
stem cell development GO:0048864 82 0.018
protein import into nucleus GO:0006606 3 0.017
cell cycle process GO:0022402 53 0.017
protein polyubiquitination GO:0000209 4 0.017
regulation of mrna splicing via spliceosome GO:0048024 3 0.017
recombinational repair GO:0000725 1 0.017
protein acylation GO:0043543 3 0.017
mitotic nuclear division GO:0007067 18 0.017
regulation of embryonic development GO:0045995 47 0.017
interspecies interaction between organisms GO:0044419 4 0.017
cell surface receptor signaling pathway GO:0007166 325 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
hepaticobiliary system development GO:0061008 98 0.016
cilium organization GO:0044782 71 0.016
positive regulation of cell cycle GO:0045787 3 0.016
reproduction GO:0000003 40 0.016
cell death GO:0008219 121 0.016
hatching GO:0035188 4 0.016
positive regulation of cytokine production GO:0001819 2 0.016
brain development GO:0007420 293 0.016
mrna 3 end processing GO:0031124 2 0.016
regulation of molecular function GO:0065009 70 0.016
chromosome organization GO:0051276 31 0.016
regulation of protein transport GO:0051223 3 0.016
cellular protein metabolic process GO:0044267 129 0.016
cellular amino acid metabolic process GO:0006520 7 0.016
posttranscriptional gene silencing GO:0016441 3 0.016
oxoacid metabolic process GO:0043436 31 0.015
organic substance biosynthetic process GO:1901576 289 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 10 0.015
regulation of reproductive process GO:2000241 4 0.015
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
dorsal ventral pattern formation GO:0009953 125 0.015
multicellular organismal reproductive process GO:0048609 35 0.015
response to other organism GO:0051707 97 0.015
positive regulation of biosynthetic process GO:0009891 68 0.015
reproductive process GO:0022414 40 0.015
meiotic cell cycle process GO:1903046 3 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
transport GO:0006810 220 0.015
regulation of cell cycle phase transition GO:1901987 8 0.015
embryonic cranial skeleton morphogenesis GO:0048701 90 0.015
germ cell development GO:0007281 22 0.015
maternal determination of anterior posterior axis embryo GO:0008358 4 0.015
mrna metabolic process GO:0016071 20 0.015
positive regulation of catabolic process GO:0009896 4 0.015
skeletal system development GO:0001501 181 0.015
membrane invagination GO:0010324 1 0.015
rna splicing GO:0008380 16 0.015
cell projection assembly GO:0030031 64 0.014
regulation of cellular ketone metabolic process GO:0010565 7 0.014
embryonic axis specification GO:0000578 12 0.014
negative regulation of rna biosynthetic process GO:1902679 45 0.014
negative regulation of mitotic cell cycle GO:0045930 11 0.014
somitogenesis GO:0001756 87 0.014
nuclear division GO:0000280 23 0.014
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.014
regulation of dendrite morphogenesis GO:0048814 3 0.014
regeneration GO:0031099 91 0.014
negative regulation of myeloid cell differentiation GO:0045638 1 0.014
positive regulation of mrna processing GO:0050685 1 0.014
negative regulation of mrna splicing via spliceosome GO:0048025 1 0.014
cellular response to external stimulus GO:0071496 2 0.014
single organism nuclear import GO:1902593 3 0.014
digestive tract development GO:0048565 265 0.014
regulation of intracellular signal transduction GO:1902531 57 0.014
negative regulation of cell differentiation GO:0045596 46 0.014
developmental process involved in reproduction GO:0003006 27 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
somite development GO:0061053 96 0.013
respiratory electron transport chain GO:0022904 2 0.013
regulation of nucleocytoplasmic transport GO:0046822 2 0.013
cell cycle phase transition GO:0044770 9 0.013
modification of morphology or physiology of other organism GO:0035821 4 0.013
double strand break repair via homologous recombination GO:0000724 1 0.013
negative regulation of synapse assembly GO:0051964 2 0.013
chemosensory behavior GO:0007635 1 0.013
cell division GO:0051301 20 0.013
negative regulation of mitosis GO:0045839 3 0.013
regulation of cell activation GO:0050865 1 0.013
mesenchyme development GO:0060485 127 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
regulation of growth GO:0040008 42 0.013
neuron projection morphogenesis GO:0048812 161 0.013
digestive system development GO:0055123 289 0.013
macromolecule localization GO:0033036 54 0.012
alternative mrna splicing via spliceosome GO:0000380 1 0.012
rna modification GO:0009451 2 0.012
regulation of localization GO:0032879 104 0.012
anterior posterior axis specification GO:0009948 20 0.012
protein import GO:0017038 3 0.012
gene silencing by rna GO:0031047 4 0.012
regulation of glial cell differentiation GO:0045685 4 0.012
regulation of nuclear division GO:0051783 9 0.012
mechanosensory behavior GO:0007638 2 0.012
positive regulation of apoptotic signaling pathway GO:2001235 1 0.012
positive regulation of glial cell differentiation GO:0045687 1 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
regulation of mitotic cell cycle GO:0007346 25 0.011
negative regulation of cell cycle process GO:0010948 9 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
regulation of neuron differentiation GO:0045664 56 0.011
negative regulation of multi organism process GO:0043901 3 0.011
protein localization GO:0008104 40 0.011
acylglycerol homeostasis GO:0055090 2 0.011
regulation of response to cytokine stimulus GO:0060759 3 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
regulation of protein complex assembly GO:0043254 3 0.011
cellular macromolecule catabolic process GO:0044265 12 0.011
stem cell division GO:0017145 1 0.011
immune system development GO:0002520 191 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.011
response to light stimulus GO:0009416 46 0.011
response to nutrient GO:0007584 3 0.011
single organism biosynthetic process GO:0044711 71 0.011
regulation of chromosome segregation GO:0051983 1 0.011
response to wounding GO:0009611 116 0.011
mitochondrion organization GO:0007005 4 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.010
regulation of response to stress GO:0080134 36 0.010
neural crest cell development GO:0014032 62 0.010
sexual reproduction GO:0019953 36 0.010
transmembrane transport GO:0055085 120 0.010
developmental growth involved in morphogenesis GO:0060560 86 0.010
convergent extension involved in gastrulation GO:0060027 71 0.010
mitotic cell cycle embryonic GO:0045448 2 0.010
system process GO:0003008 185 0.010
cell cycle arrest GO:0007050 1 0.010
mesenchymal cell differentiation GO:0048762 87 0.010
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.010

paf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
organ system cancer DOID:0050686 0 0.025
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.012