Danio rerio

66 known processes

pak1

p21/Cdc42/Rac1-activated kinase 1

(Aliases: cb761,wu:fj97h10)

pak1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
single organism organelle organization GO:1902589 199 0.758
cytoskeleton organization GO:0007010 96 0.745
cellular component morphogenesis GO:0032989 336 0.688
digestive system development GO:0055123 289 0.678
cell projection assembly GO:0030031 64 0.667
actin cytoskeleton organization GO:0030036 63 0.653
actin filament based process GO:0030029 64 0.632
cellular component assembly GO:0022607 170 0.574
organelle assembly GO:0070925 110 0.546
negative regulation of cellular process GO:0048523 283 0.534
cellular component biogenesis GO:0044085 178 0.492
regulation of cell projection assembly GO:0060491 4 0.424
negative regulation of biological process GO:0048519 304 0.415
locomotion GO:0040011 313 0.364
cell morphogenesis GO:0000902 289 0.353
regulation of cell shape GO:0008360 1 0.343
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.336
cilium organization GO:0044782 71 0.334
embryonic organ development GO:0048568 381 0.320
regulation of circadian rhythm GO:0042752 4 0.307
phosphate containing compound metabolic process GO:0006796 108 0.290
mitotic cell cycle process GO:1903047 48 0.279
sensory organ development GO:0007423 393 0.273
regulation of cellular metabolic process GO:0031323 320 0.270
cell morphogenesis involved in differentiation GO:0000904 195 0.238
cellular protein metabolic process GO:0044267 129 0.234
kupffer s vesicle development GO:0070121 50 0.225
organelle organization GO:0006996 227 0.202
regulation of nucleocytoplasmic transport GO:0046822 2 0.201
ameboidal type cell migration GO:0001667 143 0.195
cell surface receptor signaling pathway GO:0007166 325 0.192
digestive tract morphogenesis GO:0048546 231 0.190
cell projection morphogenesis GO:0048858 244 0.189
pronephros development GO:0048793 69 0.187
cell matrix adhesion GO:0007160 4 0.181
pigmentation GO:0043473 85 0.180
nucleocytoplasmic transport GO:0006913 4 0.174
cell projection organization GO:0030030 284 0.173
central nervous system development GO:0007417 387 0.170
tor signaling GO:0031929 7 0.167
macromolecule modification GO:0043412 111 0.167
regulation of primary metabolic process GO:0080090 311 0.166
regulation of synapse organization GO:0050807 3 0.162
mitotic cell cycle GO:0000278 64 0.159
convergent extension GO:0060026 118 0.158
cell part morphogenesis GO:0032990 246 0.156
cellular localization GO:0051641 97 0.154
cellular protein modification process GO:0006464 100 0.154
regulation of cytoplasmic transport GO:1903649 4 0.151
radial glial cell differentiation GO:0060019 2 0.147
axon development GO:0061564 166 0.143
neuron differentiation GO:0030182 353 0.143
organonitrogen compound metabolic process GO:1901564 74 0.142
hematopoietic or lymphoid organ development GO:0048534 191 0.139
protein dephosphorylation GO:0006470 3 0.139
regulation of protein localization to nucleus GO:1900180 2 0.138
cyclic nucleotide metabolic process GO:0009187 18 0.137
determination of heart left right asymmetry GO:0061371 117 0.136
microtubule based process GO:0007017 60 0.130
negative regulation of cell communication GO:0010648 96 0.129
regulation of localization GO:0032879 104 0.125
digestive tract development GO:0048565 265 0.124
cytokinesis GO:0000910 3 0.122
positive regulation of macromolecule metabolic process GO:0010604 93 0.122
positive regulation of cell communication GO:0010647 56 0.113
protein targeting to nucleus GO:0044744 3 0.113
single organism intracellular transport GO:1902582 25 0.111
nucleic acid transport GO:0050657 2 0.110
nuclear transport GO:0051169 4 0.110
protein modification process GO:0036211 100 0.109
macromolecular complex subunit organization GO:0043933 74 0.107
growth GO:0040007 174 0.106
response to abiotic stimulus GO:0009628 122 0.104
larval development GO:0002164 2 0.103
gastrulation GO:0007369 208 0.102
notch signaling pathway GO:0007219 35 0.101
single organism nuclear import GO:1902593 3 0.100
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.099
startle response GO:0001964 4 0.097
nuclear import GO:0051170 3 0.096
regulation of catalytic activity GO:0050790 55 0.095
immune system process GO:0002376 241 0.095
regulation of protein transport GO:0051223 3 0.093
regulation of protein import into nucleus GO:0042306 2 0.093
regulation of intracellular protein transport GO:0033157 3 0.091
regulation of metabolic process GO:0019222 359 0.091
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.090
cilium assembly GO:0042384 58 0.089
response to external stimulus GO:0009605 264 0.089
regulation of cell morphogenesis GO:0022604 42 0.086
positive regulation of transport GO:0051050 2 0.085
regulation of filopodium assembly GO:0051489 2 0.084
cellular component movement GO:0006928 335 0.084
protein n linked glycosylation GO:0006487 1 0.082
cell cycle process GO:0022402 53 0.081
developmental growth GO:0048589 166 0.080
regulation of apoptotic process GO:0042981 98 0.079
generation of neurons GO:0048699 385 0.078
cell cycle GO:0007049 93 0.078
positive regulation of map kinase activity GO:0043406 3 0.078
regulation of nucleic acid templated transcription GO:1903506 213 0.077
multicellular organism growth GO:0035264 4 0.075
response to stress GO:0006950 263 0.074
protein localization to nucleus GO:0034504 3 0.074
cell migration GO:0016477 237 0.074
wnt signaling pathway GO:0016055 80 0.073
negative regulation of apoptotic process GO:0043066 55 0.073
protein polymerization GO:0051258 4 0.072
small molecule metabolic process GO:0044281 77 0.071
camera type eye development GO:0043010 222 0.071
regulation of anatomical structure morphogenesis GO:0022603 130 0.071
regulation of collateral sprouting in absence of injury GO:0048696 4 0.067
amine metabolic process GO:0009308 2 0.065
synaptic growth at neuromuscular junction GO:0051124 2 0.064
immune system development GO:0002520 191 0.064
peripheral nervous system neuron differentiation GO:0048934 28 0.064
peptidyl serine modification GO:0018209 2 0.062
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.061
positive regulation of protein metabolic process GO:0051247 23 0.060
regulation of wnt signaling pathway GO:0030111 53 0.060
protein metabolic process GO:0019538 183 0.059
dorsal ventral pattern formation GO:0009953 125 0.059
regulation of cellular component organization GO:0051128 86 0.058
positive regulation of cell cycle GO:0045787 3 0.058
filopodium assembly GO:0046847 5 0.056
single organism cellular localization GO:1902580 46 0.055
neuron projection development GO:0031175 180 0.055
eye development GO:0001654 277 0.055
apoptotic process GO:0006915 116 0.055
microtubule cytoskeleton organization GO:0000226 33 0.055
sensory system development GO:0048880 76 0.054
establishment of mitotic spindle localization GO:0040001 12 0.054
regulation of establishment of protein localization GO:0070201 4 0.054
positive regulation of catabolic process GO:0009896 4 0.054
phosphorus metabolic process GO:0006793 109 0.054
regulation of multicellular organism growth GO:0040014 4 0.054
regulation of synapse assembly GO:0051963 3 0.054
regulation of biological quality GO:0065008 263 0.053
positive regulation of cellular component biogenesis GO:0044089 3 0.052
hemopoiesis GO:0030097 183 0.050
regulation of multicellular organismal process GO:0051239 277 0.050
actin filament organization GO:0007015 15 0.049
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.049
programmed cell death GO:0012501 119 0.048
signal transduction GO:0007165 455 0.047
protein import into nucleus GO:0006606 3 0.047
establishment of protein localization to organelle GO:0072594 4 0.046
sensory organ morphogenesis GO:0090596 200 0.046
cytoplasmic transport GO:0016482 11 0.046
regulation of striated muscle contraction GO:0006942 2 0.046
inner ear development GO:0048839 126 0.046
neuron migration GO:0001764 22 0.045
morphogenesis of an epithelium GO:0002009 333 0.044
system process GO:0003008 185 0.044
positive regulation of cellular metabolic process GO:0031325 94 0.044
single organism metabolic process GO:0044710 217 0.043
peripheral nervous system neuron axonogenesis GO:0048936 13 0.042
cellular response to extracellular stimulus GO:0031668 2 0.042
axonogenesis GO:0007409 152 0.042
regulation of protein targeting GO:1903533 2 0.042
positive regulation of metabolic process GO:0009893 108 0.042
positive regulation of oocyte development GO:0060282 1 0.041
brain development GO:0007420 293 0.041
regeneration GO:0031099 91 0.041
regulation of response to stimulus GO:0048583 269 0.041
intracellular transport GO:0046907 32 0.040
adult behavior GO:0030534 2 0.040
positive regulation of cellular protein metabolic process GO:0032270 22 0.040
negative regulation of cell migration GO:0030336 17 0.040
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.040
maintenance of location GO:0051235 4 0.039
neurological system process GO:0050877 62 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.038
regulation of programmed cell death GO:0043067 101 0.038
cellular component assembly involved in morphogenesis GO:0010927 107 0.038
lipid storage GO:0019915 1 0.037
single organism transport GO:0044765 206 0.037
heart development GO:0007507 313 0.037
establishment of localization in cell GO:0051649 77 0.037
aging GO:0007568 2 0.036
neuromast development GO:0048884 46 0.035
sensory perception GO:0007600 39 0.035
extrinsic apoptotic signaling pathway GO:0097191 3 0.035
calcium ion transmembrane transport GO:0070588 13 0.035
positive regulation of cell death GO:0010942 29 0.035
cell cycle phase transition GO:0044770 9 0.034
hepaticobiliary system development GO:0061008 98 0.034
regionalization GO:0003002 274 0.033
head development GO:0060322 303 0.033
cell cycle g1 s phase transition GO:0044843 1 0.033
establishment of spindle orientation GO:0051294 10 0.032
striated muscle cell development GO:0055002 108 0.032
negative regulation of response to stimulus GO:0048585 104 0.032
protein import GO:0017038 3 0.032
compound eye development GO:0048749 2 0.032
regulation of metal ion transport GO:0010959 4 0.031
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.031
cell cycle g2 m phase transition GO:0044839 4 0.031
mitotic cell cycle phase transition GO:0044772 9 0.031
tissue migration GO:0090130 37 0.031
response to metal ion GO:0010038 34 0.030
cell substrate adhesion GO:0031589 4 0.030
fin development GO:0033333 77 0.030
cell migration involved in gastrulation GO:0042074 79 0.030
renal system development GO:0072001 94 0.030
cell motility GO:0048870 244 0.029
negative regulation of dna metabolic process GO:0051053 4 0.029
regulation of cytoskeleton organization GO:0051493 11 0.029
specification of symmetry GO:0009799 204 0.029
embryonic organ morphogenesis GO:0048562 274 0.029
cellular protein catabolic process GO:0044257 4 0.029
regulation of cellular amine metabolic process GO:0033238 0 0.028
regulation of developmental growth GO:0048638 38 0.028
tube morphogenesis GO:0035239 349 0.028
protein complex disassembly GO:0043241 1 0.028
wound healing GO:0042060 90 0.027
intracellular signal transduction GO:0035556 85 0.027
neuron projection regeneration GO:0031102 16 0.027
positive regulation of signaling GO:0023056 56 0.027
regulation of multicellular organismal development GO:2000026 223 0.027
regulation of calcium ion transport GO:0051924 2 0.027
activation of mapk activity GO:0000187 3 0.026
developmental growth involved in morphogenesis GO:0060560 86 0.026
regulation of kinase activity GO:0043549 15 0.026
epithelial cell migration GO:0010631 25 0.026
peptidyl serine phosphorylation GO:0018105 1 0.026
kidney development GO:0001822 92 0.025
positive regulation of signal transduction GO:0009967 56 0.025
regulation of cell communication GO:0010646 232 0.024
ventricular cardiac muscle tissue development GO:0003229 3 0.024
inner ear morphogenesis GO:0042472 63 0.024
epithelial tube morphogenesis GO:0060562 148 0.024
protein complex biogenesis GO:0070271 30 0.024
g1 s transition of mitotic cell cycle GO:0000082 1 0.024
positive regulation of apoptotic signaling pathway GO:2001235 1 0.024
neuron projection morphogenesis GO:0048812 161 0.024
regulation of growth GO:0040008 42 0.023
regulation of molecular function GO:0065009 70 0.023
regulation of cellular ketone metabolic process GO:0010565 7 0.023
establishment of spindle localization GO:0051293 12 0.023
response to starvation GO:0042594 5 0.023
regulation of mitosis GO:0007088 9 0.023
somatic stem cell maintenance GO:0035019 1 0.022
ph reduction GO:0045851 1 0.022
regulation of cell death GO:0010941 103 0.022
establishment of localization GO:0051234 244 0.022
regulation of signaling GO:0023051 235 0.021
positive regulation of cellular amine metabolic process GO:0033240 0 0.021
regulation of microtubule cytoskeleton organization GO:0070507 3 0.021
cilium morphogenesis GO:0060271 85 0.021
urogenital system development GO:0001655 97 0.021
convergent extension involved in gastrulation GO:0060027 71 0.021
cell substrate junction assembly GO:0007044 2 0.021
biological adhesion GO:0022610 40 0.021
gtp catabolic process GO:0006184 2 0.021
peripheral nervous system neuron development GO:0048935 22 0.021
cellular component disassembly GO:0022411 1 0.021
determination of bilateral symmetry GO:0009855 204 0.021
mesenchymal cell development GO:0014031 78 0.021
regulation of protein ubiquitination GO:0031396 3 0.021
regulation of neuron differentiation GO:0045664 56 0.020
phagocytosis engulfment GO:0006911 1 0.020
protein complex assembly GO:0006461 30 0.020
response to wounding GO:0009611 116 0.020
regulation of transmembrane transporter activity GO:0022898 2 0.020
regulation of cell matrix adhesion GO:0001952 1 0.020
phosphorylation GO:0016310 69 0.020
regulation of cell projection organization GO:0031344 44 0.020
regulation of phosphate metabolic process GO:0019220 43 0.019
positive regulation of embryonic development GO:0040019 3 0.019
regulation of developmental process GO:0050793 247 0.019
cell cell recognition GO:0009988 1 0.019
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.019
epithelial cell morphogenesis GO:0003382 2 0.019
regulation of dna replication GO:0006275 3 0.019
neuromast deposition GO:0048885 9 0.019
cellular protein complex assembly GO:0043623 19 0.019
single organism localization GO:1902578 225 0.018
g2 m transition of mitotic cell cycle GO:0000086 4 0.018
body morphogenesis GO:0010171 16 0.018
negative regulation of wnt signaling pathway GO:0030178 30 0.018
mitotic nuclear division GO:0007067 18 0.018
negative regulation of signal transduction GO:0009968 94 0.018
death GO:0016265 121 0.018
regulation of cell cycle GO:0051726 52 0.018
negative regulation of kinase activity GO:0033673 4 0.017
negative regulation of signaling GO:0023057 96 0.017
positive regulation of cell proliferation GO:0008284 15 0.017
microtubule depolymerization GO:0007019 1 0.017
protein phosphorylation GO:0006468 47 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.017
regulation of anatomical structure size GO:0090066 33 0.017
cation transmembrane transport GO:0098655 65 0.017
developmental cell growth GO:0048588 52 0.017
regulation of tor signaling GO:0032006 7 0.017
epidermal cell differentiation GO:0009913 36 0.017
muscle cell fate determination GO:0007521 1 0.017
ganglioside metabolic process GO:0001573 3 0.017
posterior lateral line neuromast development GO:0048919 20 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.016
positive regulation of jak stat cascade GO:0046427 2 0.016
glial cell proliferation GO:0014009 4 0.016
positive regulation of cellular process GO:0048522 201 0.016
macromolecular complex disassembly GO:0032984 1 0.016
embryonic heart tube development GO:0035050 133 0.016
skin development GO:0043588 54 0.016
embryonic skeletal system morphogenesis GO:0048704 93 0.016
regulation of oligodendrocyte differentiation GO:0048713 1 0.016
regulation of protein phosphorylation GO:0001932 18 0.016
negative regulation of molecular function GO:0044092 23 0.016
ion transmembrane transport GO:0034220 91 0.016
cell death GO:0008219 121 0.015
regulation of cell migration GO:0030334 40 0.015
regulation of organelle organization GO:0033043 29 0.015
glycosylation GO:0070085 11 0.015
positive regulation of catalytic activity GO:0043085 25 0.015
protein localization GO:0008104 40 0.015
calcium ion dependent exocytosis GO:0017156 1 0.015
negative regulation of cellular component movement GO:0051271 18 0.015
protein complex subunit organization GO:0071822 46 0.015
regulation of cell activation GO:0050865 1 0.015
stem cell maintenance GO:0019827 4 0.015
regulation of epithelial cell proliferation GO:0050678 3 0.015
ectodermal cell differentiation GO:0010668 2 0.015
nuclear division GO:0000280 23 0.015
establishment of cell polarity GO:0030010 18 0.015
regulation of cell differentiation GO:0045595 142 0.015
actomyosin structure organization GO:0031032 53 0.015
mesenchymal cell differentiation GO:0048762 87 0.015
regulation of protein depolymerization GO:1901879 1 0.014
endothelial cell migration GO:0043542 19 0.014
positive regulation of exocytosis GO:0045921 1 0.014
transport GO:0006810 220 0.014
neural crest cell development GO:0014032 62 0.014
organ regeneration GO:0031100 1 0.014
microtubule polymerization or depolymerization GO:0031109 3 0.014
macromolecule biosynthetic process GO:0009059 227 0.014
rhythmic process GO:0048511 21 0.014
myofibril assembly GO:0030239 48 0.014
positive regulation of biological process GO:0048518 253 0.014
regulation of nucleotide catabolic process GO:0030811 2 0.014
transcription dna templated GO:0006351 181 0.014
cellular ketone metabolic process GO:0042180 11 0.014
stem cell proliferation GO:0072089 4 0.014
inorganic ion transmembrane transport GO:0098660 57 0.013
regulation of glial cell differentiation GO:0045685 4 0.013
regulation of cell cycle process GO:0010564 20 0.013
regulation of jak stat cascade GO:0046425 3 0.013
stem cell differentiation GO:0048863 117 0.013
regulation of protein catabolic process GO:0042176 1 0.013
cell substrate adherens junction assembly GO:0007045 1 0.013
taxis GO:0042330 109 0.013
positive regulation of biosynthetic process GO:0009891 68 0.013
posterior lateral line system development GO:0048915 46 0.013
macromolecular complex assembly GO:0065003 35 0.013
cellular nitrogen compound metabolic process GO:0034641 290 0.013
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.013
positive regulation of apoptotic process GO:0043065 29 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
negative regulation of protein complex assembly GO:0031333 1 0.013
inorganic cation transmembrane transport GO:0098662 50 0.013
regulation of gtp catabolic process GO:0033124 2 0.013
carbohydrate derivative metabolic process GO:1901135 61 0.013
cognition GO:0050890 1 0.013
response to corticosteroid GO:0031960 1 0.012
amino acid transport GO:0006865 2 0.012
cellular amine metabolic process GO:0044106 2 0.012
regulation of ectodermal cell fate specification GO:0042665 2 0.012
cell proliferation GO:0008283 80 0.012
biosynthetic process GO:0009058 294 0.012
divalent inorganic cation transport GO:0072511 21 0.012
kidney morphogenesis GO:0060993 15 0.012
vasculature development GO:0001944 278 0.012
negative regulation of multi organism process GO:0043901 3 0.012
developmental process involved in reproduction GO:0003006 27 0.012
ectodermal cell fate specification GO:0001715 2 0.012
mechanoreceptor differentiation GO:0042490 37 0.012
signal transduction in absence of ligand GO:0038034 1 0.012
embryonic heart tube morphogenesis GO:0003143 108 0.012
regulation of nitrogen compound metabolic process GO:0051171 251 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
regulation of protein complex assembly GO:0043254 3 0.012
ear development GO:0043583 127 0.012
negative regulation of cell motility GO:2000146 17 0.011
myeloid leukocyte differentiation GO:0002573 15 0.011
regulation of muscle contraction GO:0006937 3 0.011
regulation of cell adhesion GO:0030155 15 0.011
gland development GO:0048732 143 0.011
regulation of calcium ion dependent exocytosis GO:0017158 1 0.011
olfactory placode morphogenesis GO:0071699 7 0.011
head morphogenesis GO:0060323 8 0.011
actin polymerization or depolymerization GO:0008154 2 0.011
actin filament polymerization GO:0030041 2 0.011
positive regulation of cellular catabolic process GO:0031331 3 0.011
regulation of ectoderm development GO:2000383 2 0.011
positive regulation of programmed cell death GO:0043068 29 0.011
positive regulation of phosphate metabolic process GO:0045937 21 0.011
negative regulation of notch signaling pathway GO:0045746 6 0.011
regulation of transferase activity GO:0051338 16 0.011
canonical wnt signaling pathway GO:0060070 48 0.011
regulation of reproductive process GO:2000241 4 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
neuroblast proliferation GO:0007405 2 0.011
establishment of organelle localization GO:0051656 45 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
regulation of cellular ph GO:0030641 1 0.011
regulation of protein metabolic process GO:0051246 56 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.010
regulation of receptor mediated endocytosis GO:0048259 4 0.010
regulation of establishment of planar polarity GO:0090175 4 0.010
renal tubule morphogenesis GO:0061333 1 0.010
response to decreased oxygen levels GO:0036293 25 0.010
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.010
regulation of cellular component movement GO:0051270 55 0.010
positive regulation of response to stimulus GO:0048584 80 0.010
cellular macromolecule metabolic process GO:0044260 391 0.010
negative regulation of locomotion GO:0040013 18 0.010
negative regulation of intracellular transport GO:0032387 3 0.010
positive regulation of phosphorus metabolic process GO:0010562 21 0.010

pak1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
cancer DOID:162 0 0.033
disease of cellular proliferation DOID:14566 0 0.033
organ system cancer DOID:0050686 0 0.033
nervous system disease DOID:863 0 0.029
auditory system disease DOID:2742 0 0.023
autosomal dominant nonsyndromic deafness DOID:0050564 0 0.023
nonsyndromic deafness DOID:0050563 0 0.023
sensory system disease DOID:0050155 0 0.023
gastrointestinal system cancer DOID:3119 0 0.017
reproductive organ cancer DOID:193 0 0.014