Danio rerio

4 known processes

park7

parkinson disease (autosomal recessive, early onset) 7

(Aliases: dj1,zgc:103725)

park7 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to oxygen radical GO:0000305 2 0.681
Human
oxidation reduction process GO:0055114 41 0.640
Human Mouse
hydrogen peroxide metabolic process GO:0042743 2 0.579
Human Mouse
removal of superoxide radicals GO:0019430 2 0.543
Human
cellular respiration GO:0045333 3 0.523
Human Mouse
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.523
Human Mouse
regulation of cellular metabolic process GO:0031323 320 0.409
Human Mouse
larval development GO:0002164 2 0.382
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.327
Human Mouse
cellular macromolecule metabolic process GO:0044260 391 0.326
Human Mouse
regulation of biological quality GO:0065008 263 0.245
Human Mouse
cellular response to superoxide GO:0071451 2 0.226
Human
aging GO:0007568 2 0.223
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.223
Human
sensory organ development GO:0007423 393 0.220
regulation of molecular function GO:0065009 70 0.213
Human Mouse
reactive oxygen species biosynthetic process GO:1903409 1 0.200
Mouse
protein modification process GO:0036211 100 0.190
Human Mouse
negative regulation of programmed cell death GO:0043069 58 0.186
Human Mouse
small molecule catabolic process GO:0044282 3 0.170
Human Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.164
Human Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.160
Human Mouse
signal transduction GO:0007165 455 0.159
Human Mouse
single organism metabolic process GO:0044710 217 0.146
Human Mouse
small molecule metabolic process GO:0044281 77 0.146
Human Mouse
negative regulation of cellular process GO:0048523 283 0.138
Human Mouse
cellular ketone metabolic process GO:0042180 11 0.138
Human Mouse
response to superoxide GO:0000303 2 0.133
Human
gene expression GO:0010467 252 0.127
Human Mouse
cellular response to oxygen radical GO:0071450 2 0.126
Human
organic substance biosynthetic process GO:1901576 289 0.122
Human Mouse
nucleobase containing compound metabolic process GO:0006139 274 0.116
Human Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.114
Human Mouse
organic acid metabolic process GO:0006082 31 0.112
Human Mouse
regulation of apoptotic process GO:0042981 98 0.110
Human Mouse
ribonucleoside monophosphate catabolic process GO:0009158 4 0.109
generation of neurons GO:0048699 385 0.107
cellular protein metabolic process GO:0044267 129 0.102
Human Mouse
regulation of reactive oxygen species metabolic process GO:2000377 2 0.100
Human Mouse
organic cyclic compound metabolic process GO:1901360 301 0.099
Human Mouse
response to chemical GO:0042221 320 0.095
Human Mouse
programmed cell death GO:0012501 119 0.093
Human Mouse
regulation of cell communication GO:0010646 232 0.090
Human Mouse
nitrogen compound metabolic process GO:0006807 319 0.088
Human Mouse
regulation of metabolic process GO:0019222 359 0.087
Human Mouse
camera type eye development GO:0043010 222 0.084
regulation of primary metabolic process GO:0080090 311 0.081
Human Mouse
superoxide metabolic process GO:0006801 2 0.079
Human
regulation of response to oxidative stress GO:1902882 2 0.077
Human Mouse
single organism biosynthetic process GO:0044711 71 0.077
Human Mouse
digestive system development GO:0055123 289 0.076
multicellular organism growth GO:0035264 4 0.070
dicarboxylic acid metabolic process GO:0043648 1 0.068
intracellular signal transduction GO:0035556 85 0.067
Human Mouse
regulation of protein metabolic process GO:0051246 56 0.067
Human Mouse
cellular amide metabolic process GO:0043603 4 0.067
reactive nitrogen species metabolic process GO:2001057 0 0.065
organonitrogen compound metabolic process GO:1901564 74 0.064
Human Mouse
apoptotic process GO:0006915 116 0.063
Human Mouse
macromolecule modification GO:0043412 111 0.062
Human Mouse
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.061
regulation of cellular ketone metabolic process GO:0010565 7 0.061
Human
muscle cell differentiation GO:0042692 139 0.060
regulation of signal transduction GO:0009966 225 0.059
Human Mouse
cellular protein modification process GO:0006464 100 0.058
Human Mouse
neurotransmitter transport GO:0006836 2 0.058
Mouse
regulation of autophagy GO:0010506 3 0.056
response to hormone GO:0009725 48 0.056
Human
eye development GO:0001654 277 0.055
cellular catabolic process GO:0044248 27 0.055
Human Mouse
internal protein amino acid acetylation GO:0006475 2 0.054
cell death GO:0008219 121 0.054
Human Mouse
autophagy GO:0006914 4 0.052
nitric oxide biosynthetic process GO:0006809 2 0.051
positive regulation of rho protein signal transduction GO:0035025 0 0.051
multicellular organismal response to stress GO:0033555 2 0.051
regulation of gene expression GO:0010468 265 0.051
Human Mouse
cellular modified amino acid metabolic process GO:0006575 3 0.050
Human
carboxylic acid metabolic process GO:0019752 22 0.049
Human Mouse
mechanosensory behavior GO:0007638 2 0.049
cytoskeleton dependent intracellular transport GO:0030705 10 0.049
organelle organization GO:0006996 227 0.048
Mouse
regulation of multicellular organism growth GO:0040014 4 0.048
cellular nitrogen compound metabolic process GO:0034641 290 0.047
Human Mouse
central nervous system development GO:0007417 387 0.047
hepaticobiliary system development GO:0061008 98 0.046
cellular biosynthetic process GO:0044249 286 0.046
Human Mouse
response to metal ion GO:0010038 34 0.045
cellular response to lipopolysaccharide GO:0071222 3 0.045
peptide metabolic process GO:0006518 1 0.045
regulation of cell death GO:0010941 103 0.045
Human Mouse
positive regulation of metabolic process GO:0009893 108 0.045
Human Mouse
cellular amino acid metabolic process GO:0006520 7 0.044
Human
amine metabolic process GO:0009308 2 0.044
Human
regulation of cellular protein metabolic process GO:0032268 52 0.044
Human Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.044
Human Mouse
regulation of cellular response to oxidative stress GO:1900407 2 0.042
Human Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.042
Human
response to organic substance GO:0010033 153 0.042
Human Mouse
retina development in camera type eye GO:0060041 146 0.041
regulation of response to stimulus GO:0048583 269 0.041
Human Mouse
smooth muscle contraction GO:0006939 2 0.040
oxoacid metabolic process GO:0043436 31 0.038
Human Mouse
organic acid catabolic process GO:0016054 3 0.038
positive regulation of cellular amine metabolic process GO:0033240 0 0.038
Human
cell aging GO:0007569 2 0.037
heterocycle metabolic process GO:0046483 290 0.037
Human Mouse
cell death in response to oxidative stress GO:0036473 2 0.037
Human Mouse
nucleoside monophosphate catabolic process GO:0009125 4 0.037
regulation of cellular amine metabolic process GO:0033238 0 0.036
Human
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.036
macromolecule biosynthetic process GO:0009059 227 0.036
Human Mouse
action potential GO:0001508 19 0.036
regulation of developmental process GO:0050793 247 0.036
regulation of blood pressure GO:0008217 1 0.035
cell type specific apoptotic process GO:0097285 22 0.034
Human
microtubule based movement GO:0007018 33 0.033
regulation of programmed cell death GO:0043067 101 0.033
Human Mouse
protein metabolic process GO:0019538 183 0.033
Human Mouse
monoamine transport GO:0015844 1 0.033
Mouse
response to abiotic stimulus GO:0009628 122 0.033
positive regulation of map kinase activity GO:0043406 3 0.032
atp catabolic process GO:0006200 4 0.031
response to oxygen levels GO:0070482 25 0.030
regulation of rho protein signal transduction GO:0035023 2 0.030
nucleic acid metabolic process GO:0090304 244 0.030
Human Mouse
regulation of response to nutrient levels GO:0032107 1 0.030
mitochondrion organization GO:0007005 4 0.030
Mouse
fatty acid beta oxidation GO:0006635 1 0.030
cellular response to chemical stimulus GO:0070887 157 0.029
Human Mouse
negative regulation of biological process GO:0048519 304 0.029
Human Mouse
reactive oxygen species metabolic process GO:0072593 6 0.029
Human Mouse
purine nucleoside monophosphate catabolic process GO:0009128 4 0.028
regulation of oxidative stress induced cell death GO:1903201 2 0.028
Human Mouse
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.028
maintenance of location GO:0051235 4 0.027
lipid metabolic process GO:0006629 52 0.027
cellular response to molecule of bacterial origin GO:0071219 3 0.026
fatty acid oxidation GO:0019395 1 0.026
phosphorylation GO:0016310 69 0.025
Human Mouse
nitric oxide metabolic process GO:0046209 2 0.025
regulation of nucleoside metabolic process GO:0009118 2 0.025
Human Mouse
regulation of membrane potential GO:0042391 23 0.025
Human Mouse
erythrocyte differentiation GO:0030218 54 0.024
regulation of sarcomere organization GO:0060297 2 0.024
leukocyte proliferation GO:0070661 1 0.024
negative regulation of oxidative stress induced cell death GO:1903202 2 0.024
Human Mouse
cellular amine metabolic process GO:0044106 2 0.024
Human
homeostasis of number of cells GO:0048872 62 0.024
regulation of erk1 and erk2 cascade GO:0070372 4 0.023
liver development GO:0001889 96 0.023
response to copper ion GO:0046688 13 0.023
regulation of apoptotic signaling pathway GO:2001233 12 0.023
Human Mouse
iron ion homeostasis GO:0055072 4 0.023
cellular response to reactive oxygen species GO:0034614 2 0.023
Human Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.022
Human Mouse
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.021
cation transport GO:0006812 81 0.021
Mouse
negative regulation of apoptotic process GO:0043066 55 0.021
Human Mouse
cellular amino acid biosynthetic process GO:0008652 2 0.021
Human
cellular macromolecule biosynthetic process GO:0034645 224 0.020
Human Mouse
neuron death GO:0070997 21 0.020
Human Mouse
regulation of anatomical structure size GO:0090066 33 0.020
retrograde axon cargo transport GO:0008090 1 0.020
response to stress GO:0006950 263 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
Human
gland development GO:0048732 143 0.019
sensory organ morphogenesis GO:0090596 200 0.019
androgen metabolic process GO:0008209 2 0.019
negative regulation of cell communication GO:0010648 96 0.019
Human
regulation of biosynthetic process GO:0009889 250 0.019
Human Mouse
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 8 0.019
Human
cellular aldehyde metabolic process GO:0006081 4 0.019
Human Mouse
regulation of signaling GO:0023051 235 0.019
Human Mouse
light adaption GO:0036367 1 0.019
axon cargo transport GO:0008088 2 0.019
response to activity GO:0014823 14 0.018
response to oxygen containing compound GO:1901700 55 0.018
Human Mouse
transmission of nerve impulse GO:0019226 19 0.018
cell morphogenesis GO:0000902 289 0.018
regulation of blood vessel size GO:0050880 2 0.018
ion transport GO:0006811 114 0.018
Mouse
nucleic acid templated transcription GO:0097659 181 0.018
Human Mouse
negative regulation of cell death GO:0060548 60 0.018
Human Mouse
muscle structure development GO:0061061 196 0.017
protein stabilization GO:0050821 2 0.017
Human Mouse
cellular response to drug GO:0035690 1 0.017
negative regulation of dna metabolic process GO:0051053 4 0.017
locomotion GO:0040011 313 0.017
heterocycle biosynthetic process GO:0018130 215 0.017
Human Mouse
transcription dna templated GO:0006351 181 0.017
Human Mouse
negative regulation of metabolic process GO:0009892 86 0.016
Human Mouse
response to decreased oxygen levels GO:0036293 25 0.016
intracellular mrna localization GO:0008298 1 0.016
phosphorus metabolic process GO:0006793 109 0.016
Human Mouse
regulation of developmental growth GO:0048638 38 0.016
peptidyl serine phosphorylation GO:0018105 1 0.016
Human
response to wounding GO:0009611 116 0.016
Mouse
death GO:0016265 121 0.015
Human Mouse
female sex differentiation GO:0046660 4 0.015
guanosine containing compound metabolic process GO:1901068 4 0.015
response to lipid GO:0033993 60 0.015
Human
purine containing compound metabolic process GO:0072521 29 0.015
Human Mouse
immune system process GO:0002376 241 0.015
regulation of cytokine production GO:0001817 3 0.015
Human
negative regulation of developmental process GO:0051093 65 0.015
organic substance catabolic process GO:1901575 28 0.015
Human Mouse
transport GO:0006810 220 0.014
Human Mouse
response to temperature stimulus GO:0009266 15 0.014
erk1 and erk2 cascade GO:0070371 4 0.014
negative regulation of apoptotic signaling pathway GO:2001234 10 0.014
Human
regulation of ras gtpase activity GO:0032318 2 0.014
positive regulation of molecular function GO:0044093 33 0.014
Human Mouse
regulation of carbohydrate metabolic process GO:0006109 4 0.014
lipid oxidation GO:0034440 1 0.014
regulation of nitrogen compound metabolic process GO:0051171 251 0.014
Human Mouse
multicellular organismal signaling GO:0035637 22 0.014
myeloid cell homeostasis GO:0002262 56 0.014
activation of mapk activity GO:0000187 3 0.014
regulation of neuron apoptotic process GO:0043523 17 0.014
Human
regulation of dendrite development GO:0050773 3 0.013
embryonic organ development GO:0048568 381 0.013
cell cell signaling GO:0007267 52 0.013
Mouse
fat soluble vitamin biosynthetic process GO:0042362 2 0.013
regulation of gtpase activity GO:0043087 2 0.013
dopaminergic neuron differentiation GO:0071542 14 0.013
ribosome assembly GO:0042255 1 0.013
cation transmembrane transport GO:0098655 65 0.013
regulation of rna biosynthetic process GO:2001141 213 0.013
Human Mouse
xenobiotic metabolic process GO:0006805 4 0.013
positive regulation of cytokine production GO:0001819 2 0.013
Human
purine nucleotide metabolic process GO:0006163 27 0.013
Human Mouse
bleb assembly GO:0032060 1 0.012
oxidative demethylation GO:0070989 1 0.012
response to dexamethasone GO:0071548 1 0.012
cellular response to oxygen containing compound GO:1901701 20 0.012
Human Mouse
guanosine containing compound catabolic process GO:1901069 2 0.012
protein phosphorylation GO:0006468 47 0.012
Human
heart development GO:0007507 313 0.012
protein acetylation GO:0006473 2 0.011
Human
regulation of gtp catabolic process GO:0033124 2 0.011
hemopoiesis GO:0030097 183 0.011
positive regulation of macromolecule metabolic process GO:0010604 93 0.011
Human Mouse
alcohol biosynthetic process GO:0046165 2 0.011
Human Mouse
aromatic compound catabolic process GO:0019439 15 0.011
regulation of response to biotic stimulus GO:0002831 2 0.011
regulation of cell differentiation GO:0045595 142 0.011
negative regulation of dna replication GO:0008156 2 0.011
extracellular matrix organization GO:0030198 27 0.011
regulation of systemic arterial blood pressure GO:0003073 1 0.011
reciprocal meiotic recombination GO:0007131 1 0.011
neuron apoptotic process GO:0051402 20 0.011
Human
energy reserve metabolic process GO:0006112 2 0.011
response to other organism GO:0051707 97 0.010
regulation of tube size GO:0035150 2 0.010
nucleobase containing compound biosynthetic process GO:0034654 205 0.010
Human Mouse
phosphate containing compound metabolic process GO:0006796 108 0.010
Human Mouse
response to cadmium ion GO:0046686 14 0.010
catabolic process GO:0009056 32 0.010
Human Mouse
negative regulation of protein kinase activity GO:0006469 4 0.010
Human
negative regulation of multi organism process GO:0043901 3 0.010
carbon dioxide transport GO:0015670 3 0.010

park7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.195
mitochondrial metabolism disease DOID:700 0 0.195
inherited metabolic disorder DOID:655 0 0.195
leigh disease DOID:3652 0 0.067
disease of anatomical entity DOID:7 0 0.032
Human
immune system disease DOID:2914 0 0.018
hematopoietic system disease DOID:74 0 0.018
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
motor neuron disease DOID:231 0 0.013
central nervous system disease DOID:331 0 0.013
Human
amyotrophic lateral sclerosis DOID:332 0 0.013
neurodegenerative disease DOID:1289 0 0.013
Human
nervous system disease DOID:863 0 0.013
Human