Danio rerio

36 known processes

pax8

paired box gene 8

pax8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
brain development GO:0007420 293 0.998
Zebrafish
negative regulation of biological process GO:0048519 304 0.995
Mouse
chordate embryonic development GO:0043009 271 0.993
Zebrafish
regulation of primary metabolic process GO:0080090 311 0.986
Human Mouse Rat Worm Fly
regulation of multicellular organismal process GO:0051239 277 0.979
Mouse Fly
nucleic acid templated transcription GO:0097659 181 0.975
Human Mouse Rat Worm Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.974
Human Mouse Rat Worm Fly
positive regulation of cellular process GO:0048522 201 0.971
Human Mouse Rat Worm Fly
central nervous system development GO:0007417 387 0.968
Human Zebrafish Mouse
cellular component morphogenesis GO:0032989 336 0.967
Human Mouse Fly
epithelial tube morphogenesis GO:0060562 148 0.964
Human Mouse
embryo development ending in birth or egg hatching GO:0009792 271 0.961
Zebrafish Worm
nitrogen compound metabolic process GO:0006807 319 0.961
Human Mouse Rat Worm Fly
signal transduction GO:0007165 455 0.957
head development GO:0060322 303 0.955
Zebrafish
regulation of rna metabolic process GO:0051252 224 0.955
Human Mouse Rat Worm Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.952
Human Mouse Rat Worm Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.951
Human Mouse Rat Worm Fly
pancreas development GO:0031016 84 0.950
regulation of gene expression GO:0010468 265 0.948
Human Mouse Rat Worm Fly
aromatic compound biosynthetic process GO:0019438 217 0.946
Human Mouse Rat Worm Fly
embryonic organ morphogenesis GO:0048562 274 0.936
midbrain hindbrain boundary development GO:0030917 23 0.934
Zebrafish
cellular aromatic compound metabolic process GO:0006725 295 0.932
Human Mouse Rat Worm Fly
morphogenesis of an epithelium GO:0002009 333 0.932
rna biosynthetic process GO:0032774 181 0.930
Human Mouse Rat Worm Fly
digestive tract morphogenesis GO:0048546 231 0.930
organic cyclic compound metabolic process GO:1901360 301 0.915
Human Mouse Rat Worm Fly
regulation of cellular metabolic process GO:0031323 320 0.911
Human Mouse Rat Worm Fly
regulation of rna biosynthetic process GO:2001141 213 0.910
Human Mouse Rat Worm Fly
neural tube development GO:0021915 62 0.907
Zebrafish
regulation of nitrogen compound metabolic process GO:0051171 251 0.904
Human Mouse Rat Worm Fly
regulation of multicellular organismal development GO:2000026 223 0.899
Mouse Fly
regulation of response to stimulus GO:0048583 269 0.899
embryonic skeletal system morphogenesis GO:0048704 93 0.898
anterior posterior pattern specification GO:0009952 152 0.894
Zebrafish
regulation of nucleic acid templated transcription GO:1903506 213 0.877
Human Mouse Rat Worm Fly
regulation of macromolecule metabolic process GO:0060255 317 0.876
Human Mouse Rat Worm Fly
negative regulation of cellular process GO:0048523 283 0.853
Mouse
regulation of biosynthetic process GO:0009889 250 0.853
Human Mouse Rat Worm Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.852
Mouse Fly
sensory organ morphogenesis GO:0090596 200 0.848
heterocycle metabolic process GO:0046483 290 0.847
Human Mouse Rat Worm Fly
developmental programmed cell death GO:0010623 4 0.846
Mouse
positive regulation of metabolic process GO:0009893 108 0.842
Human Mouse Rat Worm Fly
determination of bilateral symmetry GO:0009855 204 0.841
regulation of metabolic process GO:0019222 359 0.841
Human Mouse Rat Worm Fly
floor plate development GO:0033504 15 0.837
negative regulation of stem cell differentiation GO:2000737 2 0.835
Mouse
skeletal system morphogenesis GO:0048705 102 0.832
rhombomere development GO:0021546 19 0.832
gliogenesis GO:0042063 45 0.829
cellular nitrogen compound metabolic process GO:0034641 290 0.824
Human Mouse Rat Worm Fly
apoptotic process involved in morphogenesis GO:0060561 2 0.809
Mouse
developmental process involved in reproduction GO:0003006 27 0.805
Worm
regulation of developmental process GO:0050793 247 0.802
Mouse Fly
response to chemical GO:0042221 320 0.791
Human
gene expression GO:0010467 252 0.787
Human Mouse Rat Worm Fly
cell surface receptor signaling pathway GO:0007166 325 0.780
digestive system development GO:0055123 289 0.776
neuron development GO:0048666 262 0.763
Zebrafish Fly
heterocycle biosynthetic process GO:0018130 215 0.759
Human Mouse Rat Worm Fly
nucleic acid metabolic process GO:0090304 244 0.758
Human Mouse Rat Worm Fly
otic vesicle morphogenesis GO:0071600 34 0.756
forebrain development GO:0030900 96 0.754
cell morphogenesis GO:0000902 289 0.753
Human Mouse Fly
neuron projection development GO:0031175 180 0.746
Fly
regulation of cellular biosynthetic process GO:0031326 245 0.737
Human Mouse Rat Worm Fly
chemotaxis GO:0006935 104 0.733
heart development GO:0007507 313 0.733
regulation of neuron differentiation GO:0045664 56 0.732
Fly
rna metabolic process GO:0016070 219 0.729
Human Mouse Rat Worm Fly
positive regulation of biological process GO:0048518 253 0.728
Human Mouse Rat Worm Fly
cellular component assembly GO:0022607 170 0.726
inner ear morphogenesis GO:0042472 63 0.724
nucleobase containing compound metabolic process GO:0006139 274 0.714
Human Mouse Rat Worm Fly
positive regulation of gene expression GO:0010628 71 0.714
Human Mouse Rat Worm Fly
mesodermal cell fate specification GO:0007501 12 0.710
diencephalon development GO:0021536 58 0.705
otic placode formation GO:0043049 23 0.690
skeletal system development GO:0001501 181 0.683
ear development GO:0043583 127 0.680
rostrocaudal neural tube patterning GO:0021903 29 0.678
Zebrafish
otic vesicle development GO:0071599 42 0.672
cell part morphogenesis GO:0032990 246 0.671
Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.663
Human Mouse Rat Worm Fly
embryonic organ development GO:0048568 381 0.652
cellular response to organic substance GO:0071310 105 0.644
Human
inner ear receptor cell differentiation GO:0060113 29 0.632
Zebrafish
response to external stimulus GO:0009605 264 0.626
Zebrafish
cell cell signaling GO:0007267 52 0.625
Human
embryonic cranial skeleton morphogenesis GO:0048701 90 0.619
epithelial cell morphogenesis GO:0003382 2 0.617
Human Mouse
apoptotic process involved in development GO:1902742 2 0.617
Mouse
embryonic skeletal system development GO:0048706 97 0.616
blood vessel development GO:0001568 246 0.609
taxis GO:0042330 109 0.605
mesoderm morphogenesis GO:0048332 51 0.600
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.598
Human Mouse Rat Worm Fly
midbrain development GO:0030901 28 0.597
Zebrafish
positive regulation of macromolecule metabolic process GO:0010604 93 0.594
Human Mouse Rat Worm Fly
cellular biosynthetic process GO:0044249 286 0.591
Human Mouse Rat Worm Fly
regulation of cell communication GO:0010646 232 0.588
Human
developmental growth GO:0048589 166 0.574
reproductive process GO:0022414 40 0.568
Worm
motor neuron axon guidance GO:0008045 23 0.566
macromolecule biosynthetic process GO:0009059 227 0.560
Human Mouse Rat Worm Fly
appendage morphogenesis GO:0035107 56 0.554
regulation of organ morphogenesis GO:2000027 35 0.549
Mouse Fly
adenohypophysis development GO:0021984 15 0.546
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.541
Human Mouse Rat Worm Fly
positive regulation of embryonic development GO:0040019 3 0.539
organelle organization GO:0006996 227 0.538
regulation of axonogenesis GO:0050770 32 0.538
tube morphogenesis GO:0035239 349 0.534
Human Mouse
positive regulation of rna metabolic process GO:0051254 59 0.532
Human Mouse Rat Worm Fly
angiogenesis GO:0001525 158 0.511
cardiac muscle tissue development GO:0048738 48 0.511
digestive tract development GO:0048565 265 0.509
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.509
Fly
regulation of cell differentiation GO:0045595 142 0.498
Mouse Fly
mesodermal cell differentiation GO:0048333 21 0.496
locomotion GO:0040011 313 0.492
localization of cell GO:0051674 244 0.486
neural tube patterning GO:0021532 33 0.484
Zebrafish
organic substance biosynthetic process GO:1901576 289 0.483
Human Mouse Rat Worm Fly
regulation of gastrulation GO:0010470 24 0.480
small molecule metabolic process GO:0044281 77 0.468
Human Mouse
sensory organ development GO:0007423 393 0.464
thyroid gland development GO:0030878 12 0.462
Human Zebrafish Mouse
cardiocyte differentiation GO:0035051 44 0.459
dendrite development GO:0016358 9 0.456
Fly
neurological system process GO:0050877 62 0.455
distal tubule development GO:0072017 1 0.455
Mouse
reflex GO:0060004 2 0.451
Zebrafish
negative regulation of metabolic process GO:0009892 86 0.451
developmental growth involved in morphogenesis GO:0060560 86 0.446
aorta morphogenesis GO:0035909 3 0.439
ectodermal placode formation GO:0060788 26 0.438
gastrulation GO:0007369 208 0.436
central nervous system neuron differentiation GO:0021953 74 0.427
regulation of inner ear receptor cell differentiation GO:2000980 1 0.426
brain morphogenesis GO:0048854 18 0.421
cellular component biogenesis GO:0044085 178 0.419
regulation of transcription dna templated GO:0006355 213 0.418
Human Mouse Rat Worm Fly
cellular component movement GO:0006928 335 0.415
regulation of neurogenesis GO:0050767 87 0.411
Fly
epithelial cell development GO:0002064 42 0.407
Human Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.407
Human Mouse Rat Worm Fly
embryonic eye morphogenesis GO:0048048 30 0.401
Zebrafish
regulation of mechanoreceptor differentiation GO:0045631 1 0.399
establishment of localization GO:0051234 244 0.394
Human
otic vesicle formation GO:0030916 27 0.389
nucleobase containing compound biosynthetic process GO:0034654 205 0.387
Human Mouse Rat Worm Fly
biosynthetic process GO:0009058 294 0.386
Human Mouse Rat Worm Fly
regionalization GO:0003002 274 0.385
Zebrafish Mouse
positive regulation of multicellular organismal process GO:0051240 52 0.385
Mouse
hormone transport GO:0009914 2 0.382
Human
cellular macromolecule metabolic process GO:0044260 391 0.376
Human Mouse Rat Worm Fly
retinal pigment epithelium development GO:0003406 8 0.371
positive regulation of cellular metabolic process GO:0031325 94 0.369
Human Mouse Rat Worm Fly
morphogenesis of embryonic epithelium GO:0016331 30 0.367
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.362
Human Rat Worm Fly
glial cell migration GO:0008347 3 0.361
transcription dna templated GO:0006351 181 0.356
Human Mouse Rat Worm Fly
axon guidance GO:0007411 86 0.355
inner ear development GO:0048839 126 0.355
epidermal cell differentiation GO:0009913 36 0.355
Zebrafish
compound eye development GO:0048749 2 0.353
Fly
positive regulation of nervous system development GO:0051962 25 0.352
negative regulation of cellular metabolic process GO:0031324 77 0.352
muscle tissue development GO:0060537 110 0.352
regulation of neural retina development GO:0061074 2 0.350
Fly
camera type eye development GO:0043010 222 0.350
Zebrafish Fly
blood vessel morphogenesis GO:0048514 216 0.349
negative regulation of rna metabolic process GO:0051253 48 0.346
negative regulation of macromolecule metabolic process GO:0010605 76 0.345
rhombomere morphogenesis GO:0021593 17 0.344
nephron epithelium morphogenesis GO:0072088 1 0.338
Human Mouse
hair cell differentiation GO:0035315 32 0.338
Zebrafish
negative regulation of biosynthetic process GO:0009890 55 0.335
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.332
Human Mouse Rat Worm Fly
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.328
rhombomere formation GO:0021594 12 0.327
type b pancreatic cell development GO:0003323 4 0.326
positive regulation of rna biosynthetic process GO:1902680 57 0.321
Human Mouse Rat Worm Fly
positive regulation of developmental process GO:0051094 50 0.317
Mouse
negative regulation of cell communication GO:0010648 96 0.316
pronephros development GO:0048793 69 0.314
Zebrafish Mouse
negative regulation of gene expression GO:0010629 65 0.303
ventral spinal cord development GO:0021517 35 0.302
forebrain anterior posterior pattern specification GO:0021797 3 0.301
transcription from rna polymerase ii promoter GO:0006366 80 0.299
Human Rat Worm Fly
regulation of apoptotic process GO:0042981 98 0.297
Mouse
eye development GO:0001654 277 0.297
Zebrafish Fly
hindbrain development GO:0030902 91 0.292
Zebrafish
negative regulation of response to stimulus GO:0048585 104 0.290
peripheral nervous system neuron differentiation GO:0048934 28 0.287
neuroblast differentiation GO:0014016 1 0.284
regulation of mesoderm development GO:2000380 11 0.280
neuron projection morphogenesis GO:0048812 161 0.279
Fly
larval development GO:0002164 2 0.274
Worm
cell projection organization GO:0030030 284 0.274
Fly
endocrine system development GO:0035270 65 0.271
Human Zebrafish Mouse
negative regulation of nucleic acid templated transcription GO:1903507 45 0.270
forebrain regionalization GO:0021871 4 0.269
ear morphogenesis GO:0042471 64 0.268
ventral midline development GO:0007418 13 0.266
response to glucose GO:0009749 3 0.264
nephron morphogenesis GO:0072028 2 0.264
Human Mouse
eye morphogenesis GO:0048592 144 0.262
Zebrafish Fly
axon development GO:0061564 166 0.261
negative regulation of cellular biosynthetic process GO:0031327 55 0.259
cell morphogenesis involved in differentiation GO:0000904 195 0.259
Human Mouse Fly
hypochord development GO:0055016 3 0.257
heart looping GO:0001947 94 0.257
somatic stem cell maintenance GO:0035019 1 0.256
Mouse
rhombomere 4 development GO:0021570 5 0.256
cell projection morphogenesis GO:0048858 244 0.255
Fly
determination of left right symmetry GO:0007368 179 0.246
epithelial cell differentiation GO:0030855 116 0.241
Human Zebrafish Mouse
heart morphogenesis GO:0003007 156 0.236
neuron differentiation GO:0030182 353 0.236
Zebrafish Fly
striated muscle cell differentiation GO:0051146 129 0.234
negative regulation of signal transduction GO:0009968 94 0.230
aorta development GO:0035904 4 0.228
single organism transport GO:0044765 206 0.225
Human
primary neural tube formation GO:0014020 1 0.222
cell differentiation in spinal cord GO:0021515 40 0.218
glandular epithelial cell differentiation GO:0002067 9 0.215
dorsal ventral pattern formation GO:0009953 125 0.214
spinal cord development GO:0021510 46 0.213
aging GO:0007568 2 0.206
stem cell development GO:0048864 82 0.202
Mouse
response to oxygen containing compound GO:1901700 55 0.202
determination of heart left right asymmetry GO:0061371 117 0.201
skeletal muscle tissue development GO:0007519 67 0.200
cellular component assembly involved in morphogenesis GO:0010927 107 0.199
hindbrain morphogenesis GO:0021575 22 0.199
Zebrafish
striated muscle tissue development GO:0014706 110 0.198
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.197
muscle structure development GO:0061061 196 0.196
Fly
negative regulation of programmed cell death GO:0043069 58 0.195
Mouse
response to carbohydrate GO:0009743 3 0.191
cilium morphogenesis GO:0060271 85 0.190
tube formation GO:0035148 25 0.187
Mouse
cardiac chamber morphogenesis GO:0003206 12 0.182
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.181
peripheral nervous system development GO:0007422 55 0.179
response to endogenous stimulus GO:0009719 83 0.179
Human
glial cell differentiation GO:0010001 42 0.177
cellular response to chemical stimulus GO:0070887 157 0.175
Human
regulation of macromolecule biosynthetic process GO:0010556 225 0.175
Human Mouse Rat Worm Fly
developmental maturation GO:0021700 34 0.175
ectodermal placode development GO:0071696 37 0.173
mesodermal cell fate commitment GO:0001710 14 0.173
retinal ganglion cell axon guidance GO:0031290 35 0.171
regulation of cell development GO:0060284 100 0.171
Mouse Fly
regulation of stem cell differentiation GO:2000736 4 0.170
Mouse
renal tubule development GO:0061326 5 0.170
Human Mouse
stem cell fate commitment GO:0048865 1 0.168
regulation of mesodermal cell fate specification GO:0042661 9 0.168
embryonic heart tube development GO:0035050 133 0.166
negative regulation of transcription dna templated GO:0045892 45 0.166
embryonic pattern specification GO:0009880 44 0.165
Zebrafish
hindbrain formation GO:0021576 3 0.165
Zebrafish
growth GO:0040007 174 0.164
regulation of photoreceptor cell differentiation GO:0046532 2 0.164
Fly
optic cup morphogenesis involved in camera type eye development GO:0002072 7 0.161
metencephalon development GO:0022037 27 0.158
Zebrafish
epidermis development GO:0008544 48 0.157
Zebrafish
response to stress GO:0006950 263 0.157
nephron epithelium development GO:0072009 16 0.155
Human Mouse
wound healing GO:0042060 90 0.154
positive regulation of nucleic acid templated transcription GO:1903508 57 0.153
Human Mouse Rat Worm Fly
embryonic camera type eye development GO:0031076 29 0.153
Zebrafish
regulation of signaling GO:0023051 235 0.150
Human
cell motility GO:0048870 244 0.149
appendage development GO:0048736 80 0.148
gland development GO:0048732 143 0.147
Human Zebrafish Mouse
cerebellum formation GO:0021588 2 0.140
Zebrafish
endoderm development GO:0007492 49 0.138
response to organic substance GO:0010033 153 0.136
Human
auditory receptor cell development GO:0060117 8 0.136
vasculature development GO:0001944 278 0.136
organic substance catabolic process GO:1901575 28 0.135
Worm
anterior head development GO:0097065 2 0.134
apoptotic process GO:0006915 116 0.134
Mouse
regulation of locomotion GO:0040012 55 0.133
cell fate commitment GO:0045165 99 0.132
Zebrafish Worm Fly
regulation of neuron migration GO:2001222 2 0.131
floor plate formation GO:0021508 12 0.131
transport GO:0006810 220 0.129
Human
ventral spinal cord interneuron differentiation GO:0021514 12 0.129
response to hexose GO:0009746 3 0.129
connective tissue development GO:0061448 99 0.128
single organism localization GO:1902578 225 0.128
Human
rhombomere 5 development GO:0021571 4 0.128
regulation of nervous system development GO:0051960 90 0.128
Fly
axonogenesis GO:0007409 152 0.127
embryonic viscerocranium morphogenesis GO:0048703 52 0.125
neuron projection guidance GO:0097485 86 0.125
specification of symmetry GO:0009799 204 0.123
cranial nerve development GO:0021545 42 0.123
cellular protein metabolic process GO:0044267 129 0.122
enteroendocrine cell differentiation GO:0035883 9 0.122
positive regulation of cell cycle GO:0045787 3 0.122
embryonic camera type eye morphogenesis GO:0048596 19 0.122
Zebrafish
embryonic digestive tract development GO:0048566 4 0.119
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.116
wnt signaling pathway GO:0016055 80 0.114
skin development GO:0043588 54 0.114
Zebrafish
embryonic heart tube morphogenesis GO:0003143 108 0.113
sexual reproduction GO:0019953 36 0.112
stem cell maintenance GO:0019827 4 0.111
Mouse
macromolecular complex subunit organization GO:0043933 74 0.110
regulation of anatomical structure size GO:0090066 33 0.110
stem cell differentiation GO:0048863 117 0.107
Mouse
cartilage development GO:0051216 96 0.106
photoreceptor cell differentiation GO:0046530 55 0.105
Fly
kidney development GO:0001822 92 0.104
Human Zebrafish Mouse
nephron tubule morphogenesis GO:0072078 1 0.102
Human Mouse
glial cell fate specification GO:0021780 4 0.101
negative regulation of signaling GO:0023057 96 0.101
response to wounding GO:0009611 116 0.100
regulation of developmental growth GO:0048638 38 0.099
cellular catabolic process GO:0044248 27 0.099
formation of primary germ layer GO:0001704 62 0.098
embryonic camera type eye formation GO:0060900 10 0.096
organelle fission GO:0048285 23 0.095
cellular response to endogenous stimulus GO:0071495 68 0.094
Human
positive regulation of biosynthetic process GO:0009891 68 0.093
Human Mouse Rat Worm Fly
mechanoreceptor differentiation GO:0042490 37 0.092
Zebrafish
regulation of endodermal cell fate specification GO:0042663 15 0.091
carboxylic acid catabolic process GO:0046395 3 0.089
hormone secretion GO:0046879 2 0.089
Human
meiotic nuclear division GO:0007126 4 0.089
response to monosaccharide GO:0034284 3 0.088
floor plate morphogenesis GO:0033505 12 0.087
regulation of circadian rhythm GO:0042752 4 0.086
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.086
embryonic skeletal joint development GO:0072498 3 0.085
kidney morphogenesis GO:0060993 15 0.085
Human Zebrafish Mouse
embryonic digestive tract morphogenesis GO:0048557 3 0.085
tissue regeneration GO:0042246 74 0.085
anatomical structure arrangement GO:0048532 2 0.084
glomerular epithelial cell fate commitment GO:0072314 4 0.083
positive regulation of neuron migration GO:2001224 2 0.083
mesenchyme development GO:0060485 127 0.082
otolith morphogenesis GO:0032474 8 0.081
negative regulation of multicellular organismal process GO:0051241 69 0.081
Mouse
skeletal muscle organ development GO:0060538 78 0.081
regulation of cell projection organization GO:0031344 44 0.080
otolith development GO:0048840 32 0.080
rhombomere boundary formation GO:0021654 10 0.080
left right pattern formation GO:0060972 19 0.079
organelle assembly GO:0070925 110 0.078
negative regulation of developmental process GO:0051093 65 0.078
Mouse
regulation of vasculature development GO:1901342 33 0.077
mesoderm development GO:0007498 88 0.077
foregut morphogenesis GO:0007440 4 0.076
renal tubule morphogenesis GO:0061333 1 0.076
Human Mouse
positive regulation of cellular component biogenesis GO:0044089 3 0.075
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.075
Mouse
positive regulation of stem cell proliferation GO:2000648 1 0.075
negative regulation of cell differentiation GO:0045596 46 0.075
Mouse
generation of neurons GO:0048699 385 0.074
Zebrafish Fly
glomerulus vasculature development GO:0072012 2 0.074
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.073
auditory receptor cell differentiation GO:0042491 15 0.073
regulation of axon extension GO:0030516 24 0.073
synaptic growth at neuromuscular junction GO:0051124 2 0.073
negative regulation of reproductive process GO:2000242 3 0.073
mitotic nuclear division GO:0007067 18 0.072
kidney epithelium development GO:0072073 23 0.072
Human Mouse
cognition GO:0050890 1 0.070
pituitary gland development GO:0021983 16 0.069
type b pancreatic cell differentiation GO:0003309 8 0.068
single organism organelle organization GO:1902589 199 0.068
oxoacid metabolic process GO:0043436 31 0.068
Human Mouse
stem cell proliferation GO:0072089 4 0.066
central nervous system neuron development GO:0021954 29 0.065
gastrulation with mouth forming second GO:0001702 44 0.065
germ cell development GO:0007281 22 0.065
regulation of cell fate specification GO:0042659 20 0.065
Fly
cell proliferation GO:0008283 80 0.063
negative regulation of rna biosynthetic process GO:1902679 45 0.063
oligodendrocyte cell fate specification GO:0021778 4 0.062
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.061
epithelial cell fate commitment GO:0072148 11 0.061
pharyngeal muscle development GO:0043282 4 0.060
reproduction GO:0000003 40 0.059
nephron tubule epithelial cell differentiation GO:0072160 1 0.059
Mouse
cell differentiation involved in kidney development GO:0061005 13 0.057
Mouse
negative regulation of neuron differentiation GO:0045665 10 0.057
regulation of cellular protein metabolic process GO:0032268 52 0.057
cell cycle GO:0007049 93 0.057
urogenital system development GO:0001655 97 0.057
Human Zebrafish Mouse
artery morphogenesis GO:0048844 14 0.057
establishment of localization in cell GO:0051649 77 0.056
Human
regulation of retina development in camera type eye GO:1902866 2 0.055
Fly
blood vessel endothelial cell migration GO:0043534 18 0.055
regulation of wnt signaling pathway GO:0030111 53 0.055
regulation of embryonic development GO:0045995 47 0.054
cardiac chamber development GO:0003205 19 0.053
death GO:0016265 121 0.052
Mouse
positive regulation of neurogenesis GO:0050769 24 0.052
sensory perception of pain GO:0019233 1 0.052
response to light stimulus GO:0009416 46 0.051
striated muscle cell development GO:0055002 108 0.050
ion transmembrane transport GO:0034220 91 0.050
photoreceptor cell fate commitment GO:0046552 1 0.049
Fly
tube closure GO:0060606 1 0.049
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.048
positive regulation of epithelial cell differentiation GO:0030858 2 0.048
Mouse
forebrain cell migration GO:0021885 1 0.047
fin development GO:0033333 77 0.047
cardiac cell fate commitment GO:0060911 1 0.047
ectodermal placode morphogenesis GO:0071697 32 0.047
sprouting angiogenesis GO:0002040 53 0.047
positive regulation of cellular biosynthetic process GO:0031328 68 0.046
Human Mouse Rat Worm Fly
response to lipid GO:0033993 60 0.046
peripheral nervous system neuron development GO:0048935 22 0.045
mesoderm formation GO:0001707 43 0.045
inner ear receptor cell development GO:0060119 20 0.045
Zebrafish
multi organism process GO:0051704 134 0.045
cellular response to acid chemical GO:0071229 8 0.044
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.044
regulation of heart morphogenesis GO:2000826 17 0.044
response to mechanical stimulus GO:0009612 24 0.043
muscle cell differentiation GO:0042692 139 0.043
regulation of catalytic activity GO:0050790 55 0.042
neural precursor cell proliferation GO:0061351 20 0.042
regulation of endodermal cell differentiation GO:1903224 15 0.042
epithelium migration GO:0090132 25 0.042
regulation of localization GO:0032879 104 0.042
Human
segmentation GO:0035282 97 0.041
glucose homeostasis GO:0042593 1 0.041
cardiogenic plate morphogenesis GO:0003142 1 0.041
camera type eye morphogenesis GO:0048593 108 0.040
Zebrafish Fly
ventricular system development GO:0021591 12 0.040
negative regulation of apoptotic process GO:0043066 55 0.040
Mouse
lymph vessel morphogenesis GO:0036303 25 0.039
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.039
Human Rat Worm Fly
cardiac ventricle development GO:0003231 9 0.039
negative regulation of catalytic activity GO:0043086 21 0.039
muscle organ development GO:0007517 101 0.038
Fly
bmp signaling pathway GO:0030509 52 0.038
regulation of stem cell proliferation GO:0072091 2 0.038
oligodendrocyte differentiation GO:0048709 23 0.038
artery development GO:0060840 22 0.037
renal system development GO:0072001 94 0.037
Human Zebrafish Mouse
regulation of extent of cell growth GO:0061387 29 0.037
regulation of cell motility GO:2000145 46 0.037
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.037
negative regulation of protein metabolic process GO:0051248 16 0.037
adult behavior GO:0030534 2 0.037
regulation of synapse structure and activity GO:0050803 5 0.036
post embryonic morphogenesis GO:0009886 4 0.036
cellular response to growth factor stimulus GO:0071363 39 0.036
positive regulation of cell differentiation GO:0045597 30 0.036
Mouse
lymphangiogenesis GO:0001946 25 0.035
gamete generation GO:0007276 33 0.035
determination of pancreatic left right asymmetry GO:0035469 11 0.035
cartilage development involved in endochondral bone morphogenesis GO:0060351 8 0.035
cellular protein catabolic process GO:0044257 4 0.035
axis specification GO:0009798 43 0.035
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.034
kupffer s vesicle development GO:0070121 50 0.034
regulation of signal transduction GO:0009966 225 0.034
response to drug GO:0042493 3 0.034
positive regulation of transcription dna templated GO:0045893 57 0.034
Human Mouse Rat Worm Fly
extraocular skeletal muscle development GO:0002074 3 0.033
endothelial cell migration GO:0043542 19 0.033
somite development GO:0061053 96 0.033
ribonucleotide metabolic process GO:0009259 27 0.033
cardiac muscle cell differentiation GO:0055007 30 0.033
nerve development GO:0021675 45 0.033
positive regulation of cellular component organization GO:0051130 13 0.032
Mouse
single organism metabolic process GO:0044710 217 0.032
Human Mouse
nuclear division GO:0000280 23 0.032
gtp metabolic process GO:0046039 4 0.032
cell migration GO:0016477 237 0.032
retina morphogenesis in camera type eye GO:0060042 79 0.032
Fly
dorsal aorta morphogenesis GO:0035912 3 0.032
cellular amine metabolic process GO:0044106 2 0.032
Human Mouse
rhombomere 6 development GO:0021572 4 0.032
neuron fate commitment GO:0048663 26 0.032
Fly
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.031
cellular response to stress GO:0033554 62 0.031

pax8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.510
Human
urinary system cancer DOID:3996 0 0.370
cancer DOID:162 0 0.370
disease of cellular proliferation DOID:14566 0 0.370
organ system cancer DOID:0050686 0 0.370
endocrine system disease DOID:28 0 0.298
Human
urinary system disease DOID:18 0 0.092
kidney disease DOID:557 0 0.048