Danio rerio

0 known processes

pcsk2

proprotein convertase subtilisin/kexin type 2

pcsk2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
peptide metabolic process GO:0006518 1 0.698
Mouse Worm Fly
cartilage morphogenesis GO:0060536 13 0.694
Zebrafish
mechanosensory lateral line system development GO:0048881 49 0.583
Zebrafish
cellular amide metabolic process GO:0043603 4 0.470
Mouse Worm Fly
neuromast development GO:0048884 46 0.455
Zebrafish
sensory organ development GO:0007423 393 0.442
Zebrafish
embryonic organ development GO:0048568 381 0.440
Zebrafish
embryo development ending in birth or egg hatching GO:0009792 271 0.342
Zebrafish
steroid hormone mediated signaling pathway GO:0043401 9 0.307
lateral line system development GO:0048925 76 0.298
Zebrafish
lateral line development GO:0048882 66 0.293
Zebrafish
embryonic skeletal system development GO:0048706 97 0.259
Zebrafish
long chain fatty acid metabolic process GO:0001676 1 0.223
amide biosynthetic process GO:0043604 1 0.223
signal transduction GO:0007165 455 0.217
locomotion GO:0040011 313 0.210
Worm
cellular nitrogen compound metabolic process GO:0034641 290 0.204
Mouse Worm Fly
embryonic skeletal system morphogenesis GO:0048704 93 0.201
Zebrafish
aging GO:0007568 2 0.200
Worm
inner ear development GO:0048839 126 0.190
regulation of gene expression GO:0010468 265 0.186
cellular nitrogen compound biosynthetic process GO:0044271 218 0.173
connective tissue development GO:0061448 99 0.172
Zebrafish
negative regulation of biological process GO:0048519 304 0.172
Worm
anterior lateral line development GO:0048899 5 0.171
Zebrafish
innate immune response GO:0045087 13 0.159
nik nf kappab signaling GO:0038061 1 0.159
nucleobase containing compound metabolic process GO:0006139 274 0.152
embryonic organ morphogenesis GO:0048562 274 0.146
Zebrafish
embryonic viscerocranium morphogenesis GO:0048703 52 0.144
Zebrafish
cellular biosynthetic process GO:0044249 286 0.144
sensory system development GO:0048880 76 0.143
Zebrafish
protein processing GO:0016485 12 0.134
Mouse Worm Fly
anterior lateral line system development GO:0048898 9 0.130
Zebrafish
organic substance biosynthetic process GO:1901576 289 0.129
biosynthetic process GO:0009058 294 0.125
appendage morphogenesis GO:0035107 56 0.119
Zebrafish
regulation of biological quality GO:0065008 263 0.114
Mouse Worm Fly
oxidation reduction process GO:0055114 41 0.113
regulation of defense response GO:0031347 14 0.106
synaptic target recognition GO:0008039 1 0.100
chordate embryonic development GO:0043009 271 0.099
Zebrafish
larval development GO:0002164 2 0.099
very long chain fatty acid biosynthetic process GO:0042761 4 0.097
determination of left right symmetry GO:0007368 179 0.093
nucleobase containing compound biosynthetic process GO:0034654 205 0.092
heterocycle biosynthetic process GO:0018130 215 0.087
cellular macromolecule metabolic process GO:0044260 391 0.085
fin development GO:0033333 77 0.082
Zebrafish
nitrogen compound metabolic process GO:0006807 319 0.082
Mouse Worm Fly
cartilage development GO:0051216 96 0.081
Zebrafish
positive regulation of transport GO:0051050 2 0.078
nucleic acid metabolic process GO:0090304 244 0.076
regulation of cellular biosynthetic process GO:0031326 245 0.075
central nervous system development GO:0007417 387 0.073
programmed cell death GO:0012501 119 0.071
protein metabolic process GO:0019538 183 0.070
Mouse Worm Fly
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.070
rna biosynthetic process GO:0032774 181 0.069
heart development GO:0007507 313 0.069
regulation of cellular metabolic process GO:0031323 320 0.069
gene expression GO:0010467 252 0.066
Mouse Worm Fly
negative regulation of nucleic acid templated transcription GO:1903507 45 0.066
negative regulation of cellular process GO:0048523 283 0.066
regulation of establishment of protein localization GO:0070201 4 0.064
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.060
fatty acid biosynthetic process GO:0006633 4 0.060
regulation of rna metabolic process GO:0051252 224 0.059
response to biotic stimulus GO:0009607 97 0.059
determination of bilateral symmetry GO:0009855 204 0.058
multi organism process GO:0051704 134 0.056
Worm
regulation of glucose import GO:0046324 1 0.056
membrane invagination GO:0010324 1 0.053
response to oxidative stress GO:0006979 11 0.053
maintenance of location GO:0051235 4 0.053
regulation of apoptotic process GO:0042981 98 0.052
regulation of metabolic process GO:0019222 359 0.051
response to external stimulus GO:0009605 264 0.051
response to drug GO:0042493 3 0.050
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.050
regulation of hormone levels GO:0010817 21 0.050
Mouse Worm Fly
positive regulation of leukocyte mediated cytotoxicity GO:0001912 1 0.050
pericardium morphogenesis GO:0003344 1 0.049
localization of cell GO:0051674 244 0.048
cell surface receptor signaling pathway GO:0007166 325 0.048
regulation of reproductive process GO:2000241 4 0.047
Worm
appendage development GO:0048736 80 0.046
Zebrafish
regulation of protein transport GO:0051223 3 0.045
multi organism cellular process GO:0044764 2 0.045
brain development GO:0007420 293 0.044
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.044
phosphorus metabolic process GO:0006793 109 0.044
cell motility GO:0048870 244 0.044
regulation of cytoplasmic transport GO:1903649 4 0.043
nucleic acid templated transcription GO:0097659 181 0.043
establishment of localization GO:0051234 244 0.043
organic cyclic compound biosynthetic process GO:1901362 223 0.041
regulation of macromolecule biosynthetic process GO:0010556 225 0.041
regulation of rna biosynthetic process GO:2001141 213 0.041
regulation of protein localization to nucleus GO:1900180 2 0.041
response to topologically incorrect protein GO:0035966 2 0.041
hematopoietic stem cell differentiation GO:0060218 20 0.041
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.041
cellular localization GO:0051641 97 0.041
negative regulation of macromolecule metabolic process GO:0010605 76 0.040
female sex differentiation GO:0046660 4 0.040
regulation of transcription dna templated GO:0006355 213 0.039
fatty acid elongation GO:0030497 1 0.039
hormone transport GO:0009914 2 0.038
cellular protein metabolic process GO:0044267 129 0.038
rna metabolic process GO:0016070 219 0.038
protein maturation GO:0051604 12 0.038
Mouse Worm Fly
transport GO:0006810 220 0.038
regulation of nucleocytoplasmic transport GO:0046822 2 0.037
long chain fatty acid biosynthetic process GO:0042759 1 0.037
cell death GO:0008219 121 0.037
phagocytosis GO:0006909 3 0.036
response to stress GO:0006950 263 0.036
cellular macromolecule biosynthetic process GO:0034645 224 0.036
regulation of cell communication GO:0010646 232 0.036
regulation of stem cell differentiation GO:2000736 4 0.036
cell recognition GO:0008037 19 0.036
homeostatic process GO:0042592 142 0.036
Fly
morphogenesis of an epithelium GO:0002009 333 0.035
organonitrogen compound biosynthetic process GO:1901566 47 0.035
epithelial cell differentiation GO:0030855 116 0.035
ear development GO:0043583 127 0.035
response to monosaccharide GO:0034284 3 0.035
lipid storage GO:0019915 1 0.034
regulation of multicellular organismal process GO:0051239 277 0.034
Worm
membrane lipid biosynthetic process GO:0046467 2 0.034
fin morphogenesis GO:0033334 53 0.034
Zebrafish
negative regulation of gene expression GO:0010629 65 0.033
regulation of macromolecule metabolic process GO:0060255 317 0.033
transcription from rna polymerase ii promoter GO:0006366 80 0.033
membrane fusion GO:0061025 2 0.033
urogenital system development GO:0001655 97 0.033
nucleic acid phosphodiester bond hydrolysis GO:0090305 6 0.032
regulation of nitrogen compound metabolic process GO:0051171 251 0.032
single organism membrane fusion GO:0044801 2 0.032
phosphate containing compound metabolic process GO:0006796 108 0.032
generation of neurons GO:0048699 385 0.032
aromatic compound biosynthetic process GO:0019438 217 0.032
response to external biotic stimulus GO:0043207 97 0.031
negative regulation of translation GO:0017148 1 0.031
hormone metabolic process GO:0042445 19 0.031
Mouse Worm Fly
regulation of protein targeting GO:1903533 2 0.031
cellular response to xenobiotic stimulus GO:0071466 35 0.031
detection of stimulus GO:0051606 29 0.030
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.030
response to glucose GO:0009749 3 0.030
regionalization GO:0003002 274 0.030
regulation of signal transduction GO:0009966 225 0.030
stem cell proliferation GO:0072089 4 0.030
single organism localization GO:1902578 225 0.030
regulation of intracellular protein transport GO:0033157 3 0.029
negative regulation of peptidase activity GO:0010466 10 0.029
i kappab kinase nf kappab signaling GO:0007249 4 0.028
cellular carbohydrate metabolic process GO:0044262 4 0.028
negative regulation of defense response GO:0031348 2 0.028
response to chemical GO:0042221 320 0.028
organelle fusion GO:0048284 3 0.028
system process GO:0003008 185 0.027
glucose import GO:0046323 2 0.027
cellular aromatic compound metabolic process GO:0006725 295 0.027
specification of symmetry GO:0009799 204 0.026
cellular component assembly GO:0022607 170 0.026
endocrine process GO:0050886 2 0.026
regulation of protein complex assembly GO:0043254 3 0.025
mitotic cell cycle process GO:1903047 48 0.025
response to other organism GO:0051707 97 0.025
neuron development GO:0048666 262 0.025
negative regulation of apoptotic process GO:0043066 55 0.025
negative regulation of reproductive process GO:2000242 3 0.025
Worm
interspecies interaction between organisms GO:0044419 4 0.025
zymogen activation GO:0031638 3 0.025
regulation of nucleic acid templated transcription GO:1903506 213 0.025
immunoglobulin mediated immune response GO:0016064 3 0.025
protein secretion GO:0009306 1 0.025
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.024
regulation of nik nf kappab signaling GO:1901222 1 0.024
nuclear import GO:0051170 3 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.024
regulation of protein binding GO:0043393 3 0.024
positive regulation of immune response GO:0050778 11 0.024
protein activation cascade GO:0072376 6 0.024
hormone secretion GO:0046879 2 0.024
vacuolar transport GO:0007034 2 0.024
lipid metabolic process GO:0006629 52 0.023
stem cell maintenance GO:0019827 4 0.023
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.023
regulation of carbohydrate metabolic process GO:0006109 4 0.023
regulation of localization GO:0032879 104 0.023
regulation of protein catabolic process GO:0042176 1 0.023
neuron differentiation GO:0030182 353 0.023
cell killing GO:0001906 2 0.023
catabolic process GO:0009056 32 0.023
Worm
negative regulation of rna biosynthetic process GO:1902679 45 0.023
transcription dna templated GO:0006351 181 0.023
positive regulation of cell cycle GO:0045787 3 0.023
cellular response to unfolded protein GO:0034620 2 0.023
carboxylic acid metabolic process GO:0019752 22 0.023
nuclear transport GO:0051169 4 0.022
regulation of stem cell proliferation GO:0072091 2 0.022
regulation of cytokine production GO:0001817 3 0.022
single organism metabolic process GO:0044710 217 0.022
cellular response to stress GO:0033554 62 0.022
negative regulation of protein phosphorylation GO:0001933 4 0.022
hematopoietic or lymphoid organ development GO:0048534 191 0.022
fatty acid elongation unsaturated fatty acid GO:0019368 1 0.021
regulation of programmed cell death GO:0043067 101 0.021
protein localization to nucleus GO:0034504 3 0.021
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.021
er nucleus signaling pathway GO:0006984 2 0.021
smooth muscle contraction GO:0006939 2 0.020
positive regulation of cellular metabolic process GO:0031325 94 0.020
response to carbohydrate GO:0009743 3 0.020
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.020
regulation of primary metabolic process GO:0080090 311 0.020
organelle organization GO:0006996 227 0.020
response to hexose GO:0009746 3 0.020
cellular component morphogenesis GO:0032989 336 0.020
b cell activation GO:0042113 2 0.020
regulation of cell cycle GO:0051726 52 0.020
positive regulation of stress activated mapk cascade GO:0032874 3 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.020
regulation of protein import into nucleus GO:0042306 2 0.019
protein modification process GO:0036211 100 0.019
heterocycle metabolic process GO:0046483 290 0.019
blood vessel development GO:0001568 246 0.019
energy reserve metabolic process GO:0006112 2 0.019
positive regulation of cytokine production GO:0001819 2 0.019
phagocytosis engulfment GO:0006911 1 0.019
positive regulation of neuron death GO:1901216 1 0.019
gastrulation GO:0007369 208 0.019
pericardium development GO:0060039 1 0.019
negative regulation of cellular biosynthetic process GO:0031327 55 0.019
cell proliferation GO:0008283 80 0.019
small molecule metabolic process GO:0044281 77 0.019
regulation of locomotion GO:0040012 55 0.019
Worm
regulation of cardiac muscle contraction GO:0055117 2 0.019
very long chain fatty acid metabolic process GO:0000038 4 0.019
striated muscle cell differentiation GO:0051146 129 0.018
cytokine mediated signaling pathway GO:0019221 7 0.018
regulation of multicellular organismal development GO:2000026 223 0.018
negative regulation of protein kinase activity GO:0006469 4 0.018
negative regulation of programmed cell death GO:0043069 58 0.018
cellular response to external stimulus GO:0071496 2 0.018
single organism organelle organization GO:1902589 199 0.018
regulation of hormone secretion GO:0046883 2 0.018
ribosomal small subunit biogenesis GO:0042274 2 0.018
meiotic nuclear division GO:0007126 4 0.018
regulation of binding GO:0051098 3 0.018
ameboidal type cell migration GO:0001667 143 0.017
protein complex localization GO:0031503 1 0.017
regulation of signaling GO:0023051 235 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
plasminogen activation GO:0031639 3 0.017
macroautophagy GO:0016236 1 0.017
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.017
regulation of immune system process GO:0002682 34 0.017
cellular component movement GO:0006928 335 0.017
regulation of protein metabolic process GO:0051246 56 0.017
negative regulation of cell differentiation GO:0045596 46 0.017
cellular response to organic substance GO:0071310 105 0.017
microtubule organizing center organization GO:0031023 1 0.017
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.017
macromolecule biosynthetic process GO:0009059 227 0.017
response to nutrient GO:0007584 3 0.017
regulation of peptidase activity GO:0052547 23 0.016
axon development GO:0061564 166 0.016
heart contraction GO:0060047 71 0.016
positive regulation of neural precursor cell proliferation GO:2000179 1 0.016
peptide transport GO:0015833 1 0.016
negative regulation of hydrolase activity GO:0051346 10 0.016
centrosome organization GO:0051297 1 0.016
establishment of protein localization to organelle GO:0072594 4 0.016
negative regulation of cell communication GO:0010648 96 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.016
single organism transport GO:0044765 206 0.016
positive regulation of cell adhesion GO:0045785 1 0.016
regulation of molecular function GO:0065009 70 0.016
cellular response to molecule of bacterial origin GO:0071219 3 0.016
complement activation GO:0006956 3 0.016
peptidyl serine modification GO:0018209 2 0.016
regulation of cell shape GO:0008360 1 0.015
morphogenesis of an epithelial sheet GO:0002011 49 0.015
cellular component biogenesis GO:0044085 178 0.015
apoptotic process GO:0006915 116 0.015
negative regulation of rna metabolic process GO:0051253 48 0.015
defense response GO:0006952 47 0.015
regulation of leukocyte mediated cytotoxicity GO:0001910 1 0.015
female gonad development GO:0008585 4 0.015
androgen metabolic process GO:0008209 2 0.015
positive regulation of cellular catabolic process GO:0031331 3 0.015
antimicrobial humoral response GO:0019730 2 0.015
sensory perception of smell GO:0007608 2 0.015
cognition GO:0050890 1 0.015
protein import into nucleus GO:0006606 3 0.015
cell migration GO:0016477 237 0.015
meiosis i GO:0007127 1 0.015
death GO:0016265 121 0.015
golgi vesicle transport GO:0048193 3 0.015
regulation of cell proliferation GO:0042127 37 0.015
modification of morphology or physiology of other organism GO:0035821 4 0.014
regulation of actin filament based movement GO:1903115 1 0.014
meiotic cell cycle process GO:1903046 3 0.014
carbohydrate homeostasis GO:0033500 1 0.014
Fly
mrna cleavage involved in gene silencing by mirna GO:0035279 1 0.014
carboxylic acid catabolic process GO:0046395 3 0.014
embryonic heart tube development GO:0035050 133 0.014
response to endogenous stimulus GO:0009719 83 0.014
negative regulation of secretion GO:0051048 2 0.014
cellular response to starvation GO:0009267 1 0.014
viral process GO:0016032 1 0.014
cell part morphogenesis GO:0032990 246 0.014
hemopoiesis GO:0030097 183 0.014
regulation of blood pressure GO:0008217 1 0.014
regulation of multicellular organism growth GO:0040014 4 0.014
regulation of cell motility GO:2000145 46 0.014
glucose homeostasis GO:0042593 1 0.014
cellular response to topologically incorrect protein GO:0035967 2 0.014
cellular response to biotic stimulus GO:0071216 3 0.014
protein targeting to nucleus GO:0044744 3 0.014
negative regulation of locomotion GO:0040013 18 0.014
cell cycle g2 m phase transition GO:0044839 4 0.014
organic substance catabolic process GO:1901575 28 0.014
Worm
positive regulation of cell division GO:0051781 2 0.014
negative regulation of meiotic cell cycle GO:0051447 1 0.014
negative regulation of mapk cascade GO:0043409 4 0.013
epithelial tube morphogenesis GO:0060562 148 0.013
single organism nuclear import GO:1902593 3 0.013
multicellular organism growth GO:0035264 4 0.013
regulation of leukocyte mediated immunity GO:0002703 1 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
purine ribonucleoside biosynthetic process GO:0046129 2 0.013
negative regulation of biosynthetic process GO:0009890 55 0.013
lipid digestion GO:0044241 3 0.013
response to bacterium GO:0009617 58 0.013
endoplasmic reticulum unfolded protein response GO:0030968 2 0.013
proteolysis GO:0006508 38 0.013
Mouse Worm Fly
liver development GO:0001889 96 0.013
cellular component disassembly GO:0022411 1 0.013
intracellular signal transduction GO:0035556 85 0.013
glial cell proliferation GO:0014009 4 0.013
regulation of developmental process GO:0050793 247 0.012
dna catabolic process GO:0006308 1 0.012
cellular protein catabolic process GO:0044257 4 0.012
myeloid cell differentiation GO:0030099 86 0.012
regulation of muscle contraction GO:0006937 3 0.012
sensory perception of pain GO:0019233 1 0.012
regulation of inflammatory response GO:0050727 2 0.012
regulation of cell death GO:0010941 103 0.012
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
lipid oxidation GO:0034440 1 0.012
cell proliferation involved in heart morphogenesis GO:0061323 2 0.012
immune system process GO:0002376 241 0.012
response to unfolded protein GO:0006986 2 0.012
negative regulation of signal transduction GO:0009968 94 0.012
cellular response to lipopolysaccharide GO:0071222 3 0.012
vasculature development GO:0001944 278 0.012
leukocyte mediated cytotoxicity GO:0001909 1 0.012
cellular lipid catabolic process GO:0044242 3 0.012
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.012
positive regulation of translation GO:0045727 1 0.012
regulation of response to stimulus GO:0048583 269 0.012
Worm
positive regulation of cell killing GO:0031343 2 0.012
positive regulation of signaling GO:0023056 56 0.012
regulation of system process GO:0044057 40 0.012
anterior posterior pattern specification GO:0009952 152 0.012
interaction with host GO:0051701 4 0.012
immune system development GO:0002520 191 0.012
regulation of lymphocyte mediated immunity GO:0002706 1 0.012
regulation of membrane repolarization GO:0060306 1 0.011
posttranscriptional regulation of gene expression GO:0010608 14 0.011
regulation of intracellular signal transduction GO:1902531 57 0.011
positive regulation of biological process GO:0048518 253 0.011
cellular response to extracellular stimulus GO:0031668 2 0.011
regulation of transferase activity GO:0051338 16 0.011
macromolecule modification GO:0043412 111 0.011
regulation of neural precursor cell proliferation GO:2000177 3 0.011
negative regulation of cytokine production GO:0001818 1 0.011
cellular response to light stimulus GO:0071482 4 0.011
anion transport GO:0006820 38 0.011
negative regulation of transcription dna templated GO:0045892 45 0.011
positive regulation of developmental process GO:0051094 50 0.011
gtp metabolic process GO:0046039 4 0.011
developmental programmed cell death GO:0010623 4 0.011
phosphorylation GO:0016310 69 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
guanosine containing compound catabolic process GO:1901069 2 0.011
positive regulation of biosynthetic process GO:0009891 68 0.011
centrosome cycle GO:0007098 1 0.011
muscle system process GO:0003012 20 0.011
negative regulation of multi organism process GO:0043901 3 0.011
Worm
muscle cell development GO:0055001 115 0.011
regulation of sodium ion transport GO:0002028 2 0.011
regulation of cellular component movement GO:0051270 55 0.011
regulation of meiotic cell cycle GO:0051445 1 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.011
neurotransmitter secretion GO:0007269 2 0.011
adult behavior GO:0030534 2 0.011
regulation of cysteine type endopeptidase activity GO:2000116 21 0.011
pigmentation GO:0043473 85 0.011
regulation of innate immune response GO:0045088 11 0.010
osteoclast differentiation GO:0030316 1 0.010
embryonic heart tube morphogenesis GO:0003143 108 0.010
stem cell differentiation GO:0048863 117 0.010
organelle assembly GO:0070925 110 0.010
muscle structure development GO:0061061 196 0.010
positive regulation of phosphorus metabolic process GO:0010562 21 0.010
sphingolipid biosynthetic process GO:0030148 2 0.010
positive regulation of dna metabolic process GO:0051054 1 0.010
response to vitamin b3 GO:0033552 2 0.010
response to alkaloid GO:0043279 2 0.010
photoreceptor cell fate specification GO:0043704 1 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.010

pcsk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
sensory system disease DOID:0050155 0 0.013
nervous system disease DOID:863 0 0.013
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010