Danio rerio

16 known processes

pcsk9

proprotein convertase subtilisin/kexin type 9

pcsk9 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic organ development GO:0048568 381 0.570
peptide metabolic process GO:0006518 1 0.527
regulation of gene expression GO:0010468 265 0.447
cartilage morphogenesis GO:0060536 13 0.433
sensory system development GO:0048880 76 0.426
neuromast development GO:0048884 46 0.422
immunoglobulin mediated immune response GO:0016064 3 0.398
lateral line system development GO:0048925 76 0.396
appendage morphogenesis GO:0035107 56 0.387
sensory organ development GO:0007423 393 0.335
mechanosensory lateral line system development GO:0048881 49 0.289
fin morphogenesis GO:0033334 53 0.264
connective tissue development GO:0061448 99 0.262
embryo development ending in birth or egg hatching GO:0009792 271 0.241
cellular amide metabolic process GO:0043603 4 0.239
fin development GO:0033333 77 0.234
cellular nitrogen compound metabolic process GO:0034641 290 0.234
cartilage development GO:0051216 96 0.227
chordate embryonic development GO:0043009 271 0.219
embryonic skeletal system morphogenesis GO:0048704 93 0.216
embryonic cranial skeleton morphogenesis GO:0048701 90 0.202
embryonic skeletal system development GO:0048706 97 0.190
skeletal system morphogenesis GO:0048705 102 0.181
nucleic acid templated transcription GO:0097659 181 0.171
cellular biosynthetic process GO:0044249 286 0.169
aromatic compound biosynthetic process GO:0019438 217 0.161
regulation of biosynthetic process GO:0009889 250 0.160
biosynthetic process GO:0009058 294 0.158
appendage development GO:0048736 80 0.156
regulation of transcription dna templated GO:0006355 213 0.156
embryonic viscerocranium morphogenesis GO:0048703 52 0.153
regulation of nucleic acid templated transcription GO:1903506 213 0.147
protein processing GO:0016485 12 0.145
eye development GO:0001654 277 0.144
urogenital system development GO:0001655 97 0.139
embryonic organ morphogenesis GO:0048562 274 0.135
nucleobase containing compound metabolic process GO:0006139 274 0.133
regulation of rna biosynthetic process GO:2001141 213 0.129
cellular nitrogen compound biosynthetic process GO:0044271 218 0.128
gene expression GO:0010467 252 0.126
lateral line development GO:0048882 66 0.124
negative regulation of reproductive process GO:2000242 3 0.115
rna biosynthetic process GO:0032774 181 0.113
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.111
aging GO:0007568 2 0.102
regulation of metabolic process GO:0019222 359 0.101
rna metabolic process GO:0016070 219 0.098
organic cyclic compound biosynthetic process GO:1901362 223 0.097
protein metabolic process GO:0019538 183 0.094
inner ear development GO:0048839 126 0.093
carbohydrate homeostasis GO:0033500 1 0.091
regulation of rna metabolic process GO:0051252 224 0.091
regulation of fatty acid metabolic process GO:0019217 1 0.091
cell motility GO:0048870 244 0.088
organic substance biosynthetic process GO:1901576 289 0.085
regulation of biological quality GO:0065008 263 0.083
localization of cell GO:0051674 244 0.083
hormone metabolic process GO:0042445 19 0.082
regulation of cellular biosynthetic process GO:0031326 245 0.081
water homeostasis GO:0030104 4 0.079
innate immune response GO:0045087 13 0.079
regulation of nitrogen compound metabolic process GO:0051171 251 0.076
female sex differentiation GO:0046660 4 0.076
cellular macromolecule metabolic process GO:0044260 391 0.075
nitrogen compound metabolic process GO:0006807 319 0.074
complement activation classical pathway GO:0006958 3 0.074
response to drug GO:0042493 3 0.072
heterocycle metabolic process GO:0046483 290 0.072
transcription dna templated GO:0006351 181 0.071
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.071
heterocycle biosynthetic process GO:0018130 215 0.069
establishment of localization GO:0051234 244 0.068
complement activation GO:0006956 3 0.067
organonitrogen compound metabolic process GO:1901564 74 0.067
positive regulation of nucleic acid templated transcription GO:1903508 57 0.066
negative regulation of nucleic acid templated transcription GO:1903507 45 0.064
skeletal system development GO:0001501 181 0.063
female gonad development GO:0008585 4 0.062
amide biosynthetic process GO:0043604 1 0.062
regulation of primary metabolic process GO:0080090 311 0.061
multi organism cellular process GO:0044764 2 0.061
regulation of defense response GO:0031347 14 0.061
regulation of locomotion GO:0040012 55 0.061
transport GO:0006810 220 0.059
regulation of reproductive process GO:2000241 4 0.059
brain development GO:0007420 293 0.059
locomotion GO:0040011 313 0.058
negative regulation of biological process GO:0048519 304 0.057
protein heterooligomerization GO:0051291 1 0.057
anterior lateral line development GO:0048899 5 0.056
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.056
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.054
organic cyclic compound metabolic process GO:1901360 301 0.052
nucleobase containing compound biosynthetic process GO:0034654 205 0.052
muscle fiber development GO:0048747 52 0.051
androgen metabolic process GO:0008209 2 0.051
transcription from rna polymerase ii promoter GO:0006366 80 0.051
anterior lateral line system development GO:0048898 9 0.050
natural killer cell mediated cytotoxicity GO:0042267 1 0.050
synaptic target recognition GO:0008039 1 0.050
regulation of response to stimulus GO:0048583 269 0.049
macromolecule biosynthetic process GO:0009059 227 0.047
regulation of hormone secretion GO:0046883 2 0.046
regulation of cytoplasmic transport GO:1903649 4 0.045
signal transduction GO:0007165 455 0.045
positive regulation of cytokine production GO:0001819 2 0.043
nuclear transport GO:0051169 4 0.043
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.043
blood vessel development GO:0001568 246 0.043
regulation of natural killer cell mediated immunity GO:0002715 1 0.043
protein activation cascade GO:0072376 6 0.043
positive regulation of biosynthetic process GO:0009891 68 0.043
positive regulation of immune effector process GO:0002699 3 0.042
regulation of cellular ketone metabolic process GO:0010565 7 0.041
positive regulation of transport GO:0051050 2 0.041
regulation of cytokine production GO:0001817 3 0.040
epithelial cell differentiation GO:0030855 116 0.040
regulation of ion transmembrane transporter activity GO:0032412 2 0.040
cell migration GO:0016477 237 0.040
cellular macromolecule biosynthetic process GO:0034645 224 0.040
negative regulation of programmed cell death GO:0043069 58 0.039
regulation of glucose import GO:0046324 1 0.039
negative regulation of peptidase activity GO:0010466 10 0.038
cellular aromatic compound metabolic process GO:0006725 295 0.038
negative regulation of rna metabolic process GO:0051253 48 0.038
regulation of macromolecule metabolic process GO:0060255 317 0.037
calcium ion import GO:0070509 4 0.037
negative regulation of gene expression GO:0010629 65 0.037
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.036
membrane lipid biosynthetic process GO:0046467 2 0.036
defense response GO:0006952 47 0.036
anterior posterior pattern specification GO:0009952 152 0.036
renal absorption GO:0070293 1 0.036
regulation of signal transduction GO:0009966 225 0.036
protein localization to nucleus GO:0034504 3 0.035
glucose homeostasis GO:0042593 1 0.035
positive regulation of innate immune response GO:0045089 8 0.035
retina development in camera type eye GO:0060041 146 0.035
regulation of macromolecule biosynthetic process GO:0010556 225 0.035
positive regulation of rna metabolic process GO:0051254 59 0.035
response to external biotic stimulus GO:0043207 97 0.033
regulation of stem cell differentiation GO:2000736 4 0.032
kidney development GO:0001822 92 0.032
cellular component movement GO:0006928 335 0.032
single organism localization GO:1902578 225 0.032
regulation of cellular metabolic process GO:0031323 320 0.032
regulation of hormone levels GO:0010817 21 0.032
regulation of developmental process GO:0050793 247 0.032
single organism metabolic process GO:0044710 217 0.031
regulation of multicellular organismal development GO:2000026 223 0.031
hatching GO:0035188 4 0.031
regulation of signaling GO:0023051 235 0.031
negative regulation of behavior GO:0048521 6 0.031
cell fate specification GO:0001708 68 0.030
production of molecular mediator of immune response GO:0002440 2 0.030
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.030
nucleic acid metabolic process GO:0090304 244 0.030
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.030
regulation of protein import into nucleus GO:0042306 2 0.030
regulation of production of molecular mediator of immune response GO:0002700 1 0.029
regulation of protein complex assembly GO:0043254 3 0.029
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.029
notochord development GO:0030903 54 0.029
negative regulation of mapk cascade GO:0043409 4 0.029
ameboidal type cell migration GO:0001667 143 0.029
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.028
lipid storage GO:0019915 1 0.028
negative regulation of macromolecule metabolic process GO:0010605 76 0.028
nik nf kappab signaling GO:0038061 1 0.028
homeostatic process GO:0042592 142 0.028
positive regulation of leukocyte mediated cytotoxicity GO:0001912 1 0.028
establishment of protein localization to organelle GO:0072594 4 0.027
carboxylic acid catabolic process GO:0046395 3 0.027
regulation of inflammatory response GO:0050727 2 0.027
myelin assembly GO:0032288 1 0.027
negative regulation of defense response GO:0031348 2 0.027
cranial ganglion development GO:0061550 3 0.027
positive regulation of cell division GO:0051781 2 0.026
cellular protein modification process GO:0006464 100 0.026
positive regulation of macromolecule metabolic process GO:0010604 93 0.026
positive regulation of gene expression GO:0010628 71 0.026
cell surface receptor signaling pathway GO:0007166 325 0.026
gastrulation GO:0007369 208 0.026
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.026
response to external stimulus GO:0009605 264 0.025
regulation of stem cell proliferation GO:0072091 2 0.025
single organism transport GO:0044765 206 0.025
regulation of translational initiation GO:0006446 1 0.025
cellular component morphogenesis GO:0032989 336 0.025
maintenance of location GO:0051235 4 0.025
interspecies interaction between organisms GO:0044419 4 0.025
regulation of protein binding GO:0043393 3 0.025
regulation of multicellular organismal process GO:0051239 277 0.025
protein maturation GO:0051604 12 0.024
regulation of leukocyte mediated immunity GO:0002703 1 0.024
proteolysis GO:0006508 38 0.024
head development GO:0060322 303 0.024
larval development GO:0002164 2 0.024
regulation of peptidase activity GO:0052547 23 0.024
otolith development GO:0048840 32 0.024
regulation of endopeptidase activity GO:0052548 23 0.024
regionalization GO:0003002 274 0.024
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.024
morphogenesis of an epithelium GO:0002009 333 0.024
carboxylic acid metabolic process GO:0019752 22 0.024
death GO:0016265 121 0.024
development of primary female sexual characteristics GO:0046545 4 0.024
cellular amine metabolic process GO:0044106 2 0.023
regulation of response to biotic stimulus GO:0002831 2 0.023
ear development GO:0043583 127 0.023
cell death GO:0008219 121 0.023
phagocytosis GO:0006909 3 0.023
lipid oxidation GO:0034440 1 0.022
multi organism process GO:0051704 134 0.022
monocarboxylic acid catabolic process GO:0072329 3 0.022
somitogenesis GO:0001756 87 0.022
response to other organism GO:0051707 97 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
immune system process GO:0002376 241 0.022
phosphorus metabolic process GO:0006793 109 0.022
determination of bilateral symmetry GO:0009855 204 0.022
glucose import GO:0046323 2 0.021
regulation of binding GO:0051098 3 0.021
negative regulation of cytokine production GO:0001818 1 0.021
calcium mediated signaling GO:0019722 2 0.021
hormone transport GO:0009914 2 0.021
protein targeting to nucleus GO:0044744 3 0.021
ion transmembrane transport GO:0034220 91 0.020
eye morphogenesis GO:0048592 144 0.020
organic substance transport GO:0071702 58 0.020
organonitrogen compound biosynthetic process GO:1901566 47 0.020
lymph vessel morphogenesis GO:0036303 25 0.020
protein secretion GO:0009306 1 0.020
b cell activation GO:0042113 2 0.020
wnt signaling pathway GO:0016055 80 0.020
negative regulation of hormone secretion GO:0046888 2 0.019
regulation of molecular function GO:0065009 70 0.019
somite development GO:0061053 96 0.019
negative regulation of cellular process GO:0048523 283 0.019
ovulation cycle process GO:0022602 2 0.019
nephric duct development GO:0072176 13 0.019
positive regulation of leukocyte mediated immunity GO:0002705 1 0.019
regulation of establishment of protein localization GO:0070201 4 0.019
lymph vessel development GO:0001945 27 0.019
hormone biosynthetic process GO:0042446 3 0.019
positive regulation of biological process GO:0048518 253 0.019
neuron development GO:0048666 262 0.019
regulation of transferase activity GO:0051338 16 0.019
regulation of protein transport GO:0051223 3 0.019
liver development GO:0001889 96 0.019
positive regulation of glucose transport GO:0010828 1 0.018
hepaticobiliary system development GO:0061008 98 0.018
positive regulation of cellular metabolic process GO:0031325 94 0.018
negative regulation of transcription dna templated GO:0045892 45 0.018
immunoglobulin production GO:0002377 1 0.018
dorsal ventral pattern formation GO:0009953 125 0.018
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.018
regulation of cell death GO:0010941 103 0.018
organic acid catabolic process GO:0016054 3 0.018
membrane invagination GO:0010324 1 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
cellular protein metabolic process GO:0044267 129 0.018
regulation of protein targeting GO:1903533 2 0.018
regulation of system process GO:0044057 40 0.018
somatic muscle development GO:0007525 4 0.017
pectoral fin morphogenesis GO:0035138 29 0.017
neuron differentiation GO:0030182 353 0.017
epithelial cell development GO:0002064 42 0.017
programmed cell death GO:0012501 119 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.017
negative regulation of protein phosphorylation GO:0001933 4 0.017
immune effector process GO:0002252 23 0.017
ovulation cycle GO:0042698 2 0.017
antimicrobial humoral response GO:0019730 2 0.016
response to bacterium GO:0009617 58 0.016
negative regulation of cell communication GO:0010648 96 0.016
endocrine process GO:0050886 2 0.016
positive regulation of rna biosynthetic process GO:1902680 57 0.016
hemopoiesis GO:0030097 183 0.016
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.016
single organism nuclear import GO:1902593 3 0.016
regulation of nucleocytoplasmic transport GO:0046822 2 0.016
determination of left right symmetry GO:0007368 179 0.016
cellular lipid catabolic process GO:0044242 3 0.016
regulation of intracellular protein transport GO:0033157 3 0.016
pronephros development GO:0048793 69 0.016
regulation of cellular amine metabolic process GO:0033238 0 0.016
negative regulation of kinase activity GO:0033673 4 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
positive regulation of secretion GO:0051047 1 0.015
stem cell proliferation GO:0072089 4 0.015
nuclear import GO:0051170 3 0.015
regulation of lymphocyte mediated immunity GO:0002706 1 0.015
response to monosaccharide GO:0034284 3 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
organelle organization GO:0006996 227 0.015
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.015
hindbrain development GO:0030902 91 0.015
viral process GO:0016032 1 0.015
regulation of calcium ion transport GO:0051924 2 0.015
regulation of immune system process GO:0002682 34 0.015
lipid metabolic process GO:0006629 52 0.015
regulation of carbohydrate metabolic process GO:0006109 4 0.015
regulation of metal ion transport GO:0010959 4 0.015
stem cell maintenance GO:0019827 4 0.015
mesenchyme development GO:0060485 127 0.015
regulation of protein ubiquitination GO:0031396 3 0.015
nephron development GO:0072006 31 0.014
positive regulation of cell activation GO:0050867 1 0.014
camera type eye development GO:0043010 222 0.014
macromolecule modification GO:0043412 111 0.014
cell killing GO:0001906 2 0.014
larval behavior GO:0030537 5 0.014
cellular response to organic substance GO:0071310 105 0.014
negative regulation of metabolic process GO:0009892 86 0.014
regulation of epithelial cell proliferation GO:0050678 3 0.014
regulation of cell communication GO:0010646 232 0.014
retina morphogenesis in camera type eye GO:0060042 79 0.014
regulation of chronic inflammatory response GO:0002676 1 0.014
phagocytosis engulfment GO:0006911 1 0.014
negative regulation of protein kinase activity GO:0006469 4 0.014
cellular carbohydrate metabolic process GO:0044262 4 0.014
eye photoreceptor cell development GO:0042462 30 0.014
negative regulation of sequestering of calcium ion GO:0051283 4 0.014
lipid catabolic process GO:0016042 4 0.014
cellular response to molecule of bacterial origin GO:0071219 3 0.014
adult behavior GO:0030534 2 0.014
multicellular organismal macromolecule metabolic process GO:0044259 2 0.014
system process GO:0003008 185 0.013
negative regulation of translation GO:0017148 1 0.013
cellular component biogenesis GO:0044085 178 0.013
positive regulation of defense response GO:0031349 9 0.013
negative regulation of hydrolase activity GO:0051346 10 0.013
response to glucose GO:0009749 3 0.013
blood vessel morphogenesis GO:0048514 216 0.013
vasculature development GO:0001944 278 0.013
negative regulation of cellular biosynthetic process GO:0031327 55 0.013
kidney epithelium development GO:0072073 23 0.013
positive regulation of cell cycle GO:0045787 3 0.013
wound healing GO:0042060 90 0.013
cellular component assembly GO:0022607 170 0.013
mitotic cell cycle GO:0000278 64 0.013
negative regulation of protein transport GO:0051224 3 0.013
androgen biosynthetic process GO:0006702 1 0.013
small molecule metabolic process GO:0044281 77 0.013
multicellular organism growth GO:0035264 4 0.013
regulation of protein processing GO:0070613 10 0.013
hormone secretion GO:0046879 2 0.013
negative regulation of cell death GO:0060548 60 0.013
protein modification process GO:0036211 100 0.013
regulation of transport GO:0051049 45 0.013
regulation of protein localization to nucleus GO:1900180 2 0.013
regulation of transporter activity GO:0032409 2 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
apoptotic process GO:0006915 116 0.012
leukocyte mediated cytotoxicity GO:0001909 1 0.012
translational initiation GO:0006413 3 0.012
negative regulation of multi organism process GO:0043901 3 0.012
response to chemical GO:0042221 320 0.012
response to biotic stimulus GO:0009607 97 0.012
neuronal action potential GO:0019228 18 0.012
fatty acid biosynthetic process GO:0006633 4 0.012
hematopoietic or lymphoid organ development GO:0048534 191 0.012
protein acetylation GO:0006473 2 0.012
negative regulation of rna biosynthetic process GO:1902679 45 0.012
cellular response to endogenous stimulus GO:0071495 68 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
regulation of cellular protein catabolic process GO:1903362 1 0.012
fatty acid transport GO:0015908 1 0.012
negative regulation of map kinase activity GO:0043407 2 0.012
negative regulation of proteolysis GO:0045861 10 0.012
response to carbohydrate GO:0009743 3 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.012
cellular localization GO:0051641 97 0.012
digestive tract morphogenesis GO:0048546 231 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
sex determination GO:0007530 1 0.012
negative regulation of signal transduction GO:0009968 94 0.012
sphingolipid biosynthetic process GO:0030148 2 0.012
cell migration involved in gastrulation GO:0042074 79 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
aorta development GO:0035904 4 0.012
internal protein amino acid acetylation GO:0006475 2 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
regulation of innate immune response GO:0045088 11 0.012
lens fiber cell development GO:0070307 3 0.012
regulation of cell activation GO:0050865 1 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
cell part morphogenesis GO:0032990 246 0.011
regulation of skeletal muscle tissue development GO:0048641 4 0.011
small molecule catabolic process GO:0044282 3 0.011
negative regulation of nuclear division GO:0051784 3 0.011
regulation of cell migration GO:0030334 40 0.011
single organism organelle organization GO:1902589 199 0.011
regulation of synapse organization GO:0050807 3 0.011
immune system development GO:0002520 191 0.011
cellular ketone metabolic process GO:0042180 11 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.011
regulation of phosphate metabolic process GO:0019220 43 0.011
blood vessel endothelial cell migration GO:0043534 18 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
adherens junction organization GO:0034332 4 0.011
positive regulation of cell substrate adhesion GO:0010811 1 0.011
plasminogen activation GO:0031639 3 0.011
angiogenesis GO:0001525 158 0.011
protein import GO:0017038 3 0.011
epidermal cell fate specification GO:0009957 4 0.011
axon ensheathment in central nervous system GO:0032291 2 0.011
b cell mediated immunity GO:0019724 3 0.011
nephron epithelium development GO:0072009 16 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
meiosis i GO:0007127 1 0.011
glial cell proliferation GO:0014009 4 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
positive regulation of blood circulation GO:1903524 2 0.011
fatty acid catabolic process GO:0009062 1 0.010
amine metabolic process GO:0009308 2 0.010
response to vitamin GO:0033273 3 0.010
regulation of endothelial cell proliferation GO:0001936 1 0.010
cognition GO:0050890 1 0.010
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.010
positive regulation of metabolic process GO:0009893 108 0.010
positive regulation of immune system process GO:0002684 17 0.010
response to glucocorticoid GO:0051384 1 0.010
positive regulation of production of molecular mediator of immune response GO:0002702 1 0.010
regulation of receptor activity GO:0010469 2 0.010
negative regulation of multicellular organismal process GO:0051241 69 0.010
positive regulation of inflammatory response GO:0050729 1 0.010
lateral line ganglion development GO:0048890 2 0.010
regulation of dna templated transcription in response to stress GO:0043620 0 0.010
mesoderm development GO:0007498 88 0.010
myeloid cell differentiation GO:0030099 86 0.010
lymphocyte mediated immunity GO:0002449 5 0.010
muscle organ development GO:0007517 101 0.010
anion transport GO:0006820 38 0.010

pcsk9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
disease of metabolism DOID:0014667 0 0.015
musculoskeletal system disease DOID:17 0 0.013
disease of cellular proliferation DOID:14566 0 0.010
cancer DOID:162 0 0.010