Danio rerio

0 known processes

pde10a

phosphodiesterase 10A

(Aliases: MGC56689,zgc:56689)

pde10a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell migration GO:0016477 237 0.379
cellular component movement GO:0006928 335 0.312
localization of cell GO:0051674 244 0.311
maintenance of location GO:0051235 4 0.285
embryonic organ development GO:0048568 381 0.254
cell motility GO:0048870 244 0.253
circadian sleep wake cycle GO:0042745 2 0.241
regulation of circadian sleep wake cycle GO:0042749 1 0.232
larval development GO:0002164 2 0.214
circadian sleep wake cycle sleep GO:0050802 1 0.207
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.194
signal transduction GO:0007165 455 0.176
Mouse
locomotion GO:0040011 313 0.149
negative regulation of ras protein signal transduction GO:0046580 1 0.148
cellular macromolecule biosynthetic process GO:0034645 224 0.148
regulation of multicellular organismal development GO:2000026 223 0.138
aging GO:0007568 2 0.128
regulation of synapse organization GO:0050807 3 0.124
stem cell proliferation GO:0072089 4 0.120
tube morphogenesis GO:0035239 349 0.118
response to external stimulus GO:0009605 264 0.118
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.113
sleep GO:0030431 1 0.110
response to organic substance GO:0010033 153 0.109
regulation of autophagy GO:0010506 3 0.103
regulation of signaling GO:0023051 235 0.101
Mouse
central nervous system development GO:0007417 387 0.100
digestive tract morphogenesis GO:0048546 231 0.098
circadian sleep wake cycle process GO:0022410 2 0.096
regulation of protein complex assembly GO:0043254 3 0.095
autophagy GO:0006914 4 0.095
hematopoietic or lymphoid organ development GO:0048534 191 0.094
axon extension GO:0048675 45 0.091
axonogenesis GO:0007409 152 0.090
response to wounding GO:0009611 116 0.083
response to alkaloid GO:0043279 2 0.083
regulation of nitrogen compound metabolic process GO:0051171 251 0.082
aromatic compound biosynthetic process GO:0019438 217 0.080
female sex differentiation GO:0046660 4 0.078
epidermis development GO:0008544 48 0.078
transcription dna templated GO:0006351 181 0.078
eye development GO:0001654 277 0.075
macromolecule biosynthetic process GO:0009059 227 0.075
positive regulation of biological process GO:0048518 253 0.074
cognition GO:0050890 1 0.074
regulation of multicellular organismal process GO:0051239 277 0.071
positive regulation of transport GO:0051050 2 0.071
axon development GO:0061564 166 0.071
development of primary female sexual characteristics GO:0046545 4 0.070
response to growth factor GO:0070848 39 0.069
regulation of oocyte development GO:0060281 3 0.068
blood vessel development GO:0001568 246 0.067
regulation of biosynthetic process GO:0009889 250 0.067
regulation of multicellular organism growth GO:0040014 4 0.066
embryonic organ morphogenesis GO:0048562 274 0.066
regulation of stem cell proliferation GO:0072091 2 0.064
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.064
gland development GO:0048732 143 0.063
digestive tract development GO:0048565 265 0.062
morphogenesis of an epithelium GO:0002009 333 0.061
anterior posterior pattern specification GO:0009952 152 0.061
cellular response to growth factor stimulus GO:0071363 39 0.060
synaptic growth at neuromuscular junction GO:0051124 2 0.060
positive regulation of cellular process GO:0048522 201 0.059
actin polymerization or depolymerization GO:0008154 2 0.059
regulation of gene expression GO:0010468 265 0.057
adult behavior GO:0030534 2 0.056
formation of primary germ layer GO:0001704 62 0.055
neuron neuron synaptic transmission GO:0007270 1 0.055
regulation of developmental process GO:0050793 247 0.055
regulation of rna biosynthetic process GO:2001141 213 0.053
ear development GO:0043583 127 0.052
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.051
rna metabolic process GO:0016070 219 0.051
regulation of cellular biosynthetic process GO:0031326 245 0.050
regulation of metabolic process GO:0019222 359 0.050
negative regulation of protein phosphorylation GO:0001933 4 0.049
regulation of macromolecule metabolic process GO:0060255 317 0.049
muscle structure development GO:0061061 196 0.048
neurotransmitter transport GO:0006836 2 0.047
neuron development GO:0048666 262 0.046
regulation of transcription dna templated GO:0006355 213 0.045
developmental cell growth GO:0048588 52 0.045
regulation of embryonic development GO:0045995 47 0.045
tissue remodeling GO:0048771 4 0.045
organelle organization GO:0006996 227 0.045
digestive system development GO:0055123 289 0.043
axon guidance GO:0007411 86 0.042
energy reserve metabolic process GO:0006112 2 0.042
vasculature development GO:0001944 278 0.042
heterocycle biosynthetic process GO:0018130 215 0.041
mesenchymal cell development GO:0014031 78 0.041
biosynthetic process GO:0009058 294 0.041
regulation of inflammatory response GO:0050727 2 0.040
enzyme linked receptor protein signaling pathway GO:0007167 106 0.040
homeostatic process GO:0042592 142 0.039
gastrulation GO:0007369 208 0.039
somite development GO:0061053 96 0.038
muscle cell differentiation GO:0042692 139 0.038
eye morphogenesis GO:0048592 144 0.037
regulation of circadian rhythm GO:0042752 4 0.037
nucleic acid templated transcription GO:0097659 181 0.037
neuron projection extension GO:1990138 45 0.037
pancreas development GO:0031016 84 0.037
regulation of anatomical structure morphogenesis GO:0022603 130 0.036
negative regulation of cellular process GO:0048523 283 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.036
regulation of epithelial cell proliferation GO:0050678 3 0.036
chordate embryonic development GO:0043009 271 0.036
cellular nitrogen compound biosynthetic process GO:0044271 218 0.036
regulation of binding GO:0051098 3 0.035
neurotransmitter secretion GO:0007269 2 0.035
lipid storage GO:0019915 1 0.035
post embryonic organ development GO:0048569 4 0.035
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.035
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.035
synaptic vesicle localization GO:0097479 1 0.035
release of sequestered calcium ion into cytosol GO:0051209 3 0.035
regulation of protein polymerization GO:0032271 2 0.034
sensory perception of chemical stimulus GO:0007606 3 0.034
cellular response to organic substance GO:0071310 105 0.034
cell proliferation GO:0008283 80 0.034
regulation of neurotransmitter secretion GO:0046928 1 0.034
multicellular organism growth GO:0035264 4 0.033
cortical cytoskeleton organization GO:0030865 1 0.033
regulation of programmed cell death GO:0043067 101 0.033
sensory organ development GO:0007423 393 0.033
neuron projection guidance GO:0097485 86 0.032
regulation of cell shape GO:0008360 1 0.032
hard palate development GO:0060022 4 0.032
cell migration involved in gastrulation GO:0042074 79 0.032
positive regulation of immune effector process GO:0002699 3 0.032
metal ion transport GO:0030001 58 0.030
regulation of cell communication GO:0010646 232 0.030
Mouse
response to chemical GO:0042221 320 0.029
ameboidal type cell migration GO:0001667 143 0.029
fin development GO:0033333 77 0.029
regulation of cellular component movement GO:0051270 55 0.029
response to external biotic stimulus GO:0043207 97 0.029
cell growth GO:0016049 57 0.029
protein secretion GO:0009306 1 0.029
regulation of biological quality GO:0065008 263 0.029
embryo development ending in birth or egg hatching GO:0009792 271 0.028
regulation of cytokine production GO:0001817 3 0.028
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.028
negative regulation of biological process GO:0048519 304 0.028
cellular response to oxygen levels GO:0071453 1 0.028
negative regulation of protein kinase b signaling GO:0051898 2 0.028
cell fate specification GO:0001708 68 0.028
positive regulation of cellular catabolic process GO:0031331 3 0.028
positive regulation of cell division GO:0051781 2 0.027
regulation of protein transport GO:0051223 3 0.027
regulation of establishment of protein localization GO:0070201 4 0.027
regulation of stem cell differentiation GO:2000736 4 0.027
developmental growth involved in morphogenesis GO:0060560 86 0.027
negative regulation of gene expression GO:0010629 65 0.027
nitrogen compound metabolic process GO:0006807 319 0.027
gene expression GO:0010467 252 0.027
response to endogenous stimulus GO:0009719 83 0.026
programmed cell death GO:0012501 119 0.026
extrinsic apoptotic signaling pathway GO:0097191 3 0.025
response to transition metal nanoparticle GO:1990267 28 0.025
cell morphogenesis involved in differentiation GO:0000904 195 0.025
peripheral nervous system development GO:0007422 55 0.025
dopamine metabolic process GO:0042417 2 0.025
positive regulation of cellular component biogenesis GO:0044089 3 0.025
convergent extension involved in gastrulation GO:0060027 71 0.025
positive regulation of secretion GO:0051047 1 0.025
regulation of synapse assembly GO:0051963 3 0.025
fin regeneration GO:0031101 51 0.025
synaptic vesicle transport GO:0048489 1 0.024
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.024
modulation by virus of host morphology or physiology GO:0019048 1 0.024
negative regulation of protein complex assembly GO:0031333 1 0.024
negative regulation of feeding behavior GO:2000252 2 0.024
regulation of cellular metabolic process GO:0031323 320 0.024
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.024
blood vessel morphogenesis GO:0048514 216 0.024
regulation of nucleic acid templated transcription GO:1903506 213 0.024
negative regulation of multicellular organismal process GO:0051241 69 0.024
mesodermal cell migration GO:0008078 12 0.024
immune system development GO:0002520 191 0.023
nucleic acid metabolic process GO:0090304 244 0.023
cell morphogenesis GO:0000902 289 0.023
regionalization GO:0003002 274 0.023
regulation of macromolecule biosynthetic process GO:0010556 225 0.023
ectodermal placode morphogenesis GO:0071697 32 0.023
head development GO:0060322 303 0.022
embryonic heart tube development GO:0035050 133 0.022
positive regulation of rna metabolic process GO:0051254 59 0.022
developmental pigmentation GO:0048066 48 0.022
generation of neurons GO:0048699 385 0.022
maternal determination of anterior posterior axis embryo GO:0008358 4 0.022
regulation of intracellular signal transduction GO:1902531 57 0.022
Mouse
regulation of primary metabolic process GO:0080090 311 0.022
actin filament polymerization GO:0030041 2 0.022
positive regulation of cell cycle GO:0045787 3 0.021
positive regulation of gene expression GO:0010628 71 0.021
cellular response to molecule of bacterial origin GO:0071219 3 0.021
positive regulation of catabolic process GO:0009896 4 0.021
transcription from rna polymerase ii promoter GO:0006366 80 0.021
ectodermal placode formation GO:0060788 26 0.021
rna biosynthetic process GO:0032774 181 0.021
exocytosis GO:0006887 1 0.021
positive regulation of multicellular organismal process GO:0051240 52 0.021
regulation of cellular component size GO:0032535 30 0.021
cellular response to chemical stimulus GO:0070887 157 0.021
cytosolic calcium ion transport GO:0060401 3 0.020
regulation of cell proliferation GO:0042127 37 0.020
cellular macromolecule metabolic process GO:0044260 391 0.020
intracellular signal transduction GO:0035556 85 0.020
Mouse
heterocycle metabolic process GO:0046483 290 0.020
positive regulation of secretion by cell GO:1903532 1 0.020
transport GO:0006810 220 0.020
regulation of localization GO:0032879 104 0.020
regulation of cell differentiation GO:0045595 142 0.019
cell projection organization GO:0030030 284 0.019
brain development GO:0007420 293 0.019
positive regulation of protein complex assembly GO:0031334 2 0.019
otic placode formation GO:0043049 23 0.019
cellular response to biotic stimulus GO:0071216 3 0.019
neuroblast proliferation GO:0007405 2 0.019
organic substance biosynthetic process GO:1901576 289 0.019
inner ear morphogenesis GO:0042472 63 0.018
cellular response to hypoxia GO:0071456 1 0.018
regulation of response to stimulus GO:0048583 269 0.018
Mouse
ear morphogenesis GO:0042471 64 0.018
neuron projection morphogenesis GO:0048812 161 0.018
regulation of signal transduction GO:0009966 225 0.018
Mouse
establishment of synaptic vesicle localization GO:0097480 1 0.018
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
growth GO:0040007 174 0.018
vestibular receptor cell differentiation GO:0060114 3 0.018
gtp metabolic process GO:0046039 4 0.018
positive regulation of cellular biosynthetic process GO:0031328 68 0.017
negative regulation of catabolic process GO:0009895 3 0.017
striated muscle cell development GO:0055002 108 0.017
regulation of neurogenesis GO:0050767 87 0.017
skin development GO:0043588 54 0.017
response to stress GO:0006950 263 0.017
regulation of exocytosis GO:0017157 1 0.017
determination of bilateral symmetry GO:0009855 204 0.017
nucleobase containing compound metabolic process GO:0006139 274 0.017
cellular macromolecular complex assembly GO:0034622 24 0.017
regulation of organelle assembly GO:1902115 4 0.017
negative regulation of metabolic process GO:0009892 86 0.017
cellular response to nutrient levels GO:0031669 2 0.017
inner ear development GO:0048839 126 0.017
cell surface receptor signaling pathway GO:0007166 325 0.016
positive regulation of nucleic acid templated transcription GO:1903508 57 0.016
regulation of neurotransmitter transport GO:0051588 1 0.016
compound eye development GO:0048749 2 0.016
cellular carbohydrate metabolic process GO:0044262 4 0.016
guanosine containing compound metabolic process GO:1901068 4 0.016
regulation of axon extension GO:0030516 24 0.016
regulation of synaptic vesicle transport GO:1902803 1 0.016
fatty acid transport GO:0015908 1 0.016
regulation of extent of cell growth GO:0061387 29 0.016
long chain fatty acid transport GO:0015909 1 0.016
cranial suture morphogenesis GO:0060363 1 0.016
astrocyte differentiation GO:0048708 1 0.016
negative regulation of signaling GO:0023057 96 0.016
cell part morphogenesis GO:0032990 246 0.016
cell fate commitment GO:0045165 99 0.016
ras protein signal transduction GO:0007265 7 0.016
hemopoiesis GO:0030097 183 0.016
macroautophagy GO:0016236 1 0.015
pigment cell differentiation GO:0050931 38 0.015
developmental growth GO:0048589 166 0.015
organic cyclic compound biosynthetic process GO:1901362 223 0.015
glial cell differentiation GO:0010001 42 0.015
negative regulation of cellular component organization GO:0051129 16 0.015
neuron projection development GO:0031175 180 0.015
endoderm development GO:0007492 49 0.015
small gtpase mediated signal transduction GO:0007264 8 0.015
regulation of cell death GO:0010941 103 0.015
stem cell development GO:0048864 82 0.015
segmentation GO:0035282 97 0.015
urogenital system development GO:0001655 97 0.015
regulation of response to stress GO:0080134 36 0.015
vestibular receptor cell development GO:0060118 3 0.015
single organismal cell cell adhesion GO:0016337 29 0.015
membrane fusion GO:0061025 2 0.015
regulation of metal ion transport GO:0010959 4 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.014
regulation of cartilage development GO:0061035 7 0.014
nitric oxide metabolic process GO:0046209 2 0.014
sequestering of metal ion GO:0051238 3 0.014
regulation of gtpase activity GO:0043087 2 0.014
taxis GO:0042330 109 0.014
regulation of sequestering of calcium ion GO:0051282 4 0.014
positive regulation of cell adhesion GO:0045785 1 0.014
convergent extension GO:0060026 118 0.014
bone remodeling GO:0046849 2 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
hormone transport GO:0009914 2 0.014
protein polymerization GO:0051258 4 0.014
muscle organ development GO:0007517 101 0.014
death GO:0016265 121 0.014
sensory perception of smell GO:0007608 2 0.014
phagocytosis GO:0006909 3 0.014
locus ceruleus development GO:0021703 3 0.014
regulation of cell motility GO:2000145 46 0.014
carbohydrate homeostasis GO:0033500 1 0.014
positive regulation of biosynthetic process GO:0009891 68 0.014
embryonic cranial skeleton morphogenesis GO:0048701 90 0.014
endocrine system development GO:0035270 65 0.014
regulation of leukocyte mediated immunity GO:0002703 1 0.014
endodermal cell fate specification GO:0001714 17 0.014
negative regulation of cell communication GO:0010648 96 0.013
regulation of apoptotic process GO:0042981 98 0.013
response to other organism GO:0051707 97 0.013
stem cell maintenance GO:0019827 4 0.013
neuron differentiation GO:0030182 353 0.013
regulation of cytoplasmic transport GO:1903649 4 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
cellular aromatic compound metabolic process GO:0006725 295 0.013
protein acetylation GO:0006473 2 0.013
cell aggregation GO:0098743 3 0.013
negative regulation of epithelial cell migration GO:0010633 1 0.013
regeneration GO:0031099 91 0.013
sensory organ morphogenesis GO:0090596 200 0.013
stem cell division GO:0017145 1 0.013
positive regulation of cytoskeleton organization GO:0051495 3 0.013
positive regulation of transcription dna templated GO:0045893 57 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
regulation of cell migration GO:0030334 40 0.012
dopaminergic neuron differentiation GO:0071542 14 0.012
regulation of cell activation GO:0050865 1 0.012
regulation of chondrocyte differentiation GO:0032330 1 0.012
single organism organelle organization GO:1902589 199 0.012
regulation of nucleoside metabolic process GO:0009118 2 0.012
cell death GO:0008219 121 0.012
negative regulation of cytokine production GO:0001818 1 0.012
somitogenesis GO:0001756 87 0.012
cellular response to extracellular stimulus GO:0031668 2 0.012
morphogenesis of an epithelial sheet GO:0002011 49 0.012
female gonad development GO:0008585 4 0.012
ion homeostasis GO:0050801 41 0.012
regulation of cell maturation GO:1903429 1 0.012
regulation of bone remodeling GO:0046850 2 0.012
somatic muscle development GO:0007525 4 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
regulation of reactive oxygen species metabolic process GO:2000377 2 0.012
striated muscle tissue development GO:0014706 110 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
camera type eye morphogenesis GO:0048593 108 0.012
mucopolysaccharide metabolic process GO:1903510 2 0.012
regulation of locomotion GO:0040012 55 0.012
negative regulation of sequestering of calcium ion GO:0051283 4 0.012
regulation of dna replication GO:0006275 3 0.012
macromolecular complex subunit organization GO:0043933 74 0.011
locomotory behavior GO:0007626 34 0.011
glucose homeostasis GO:0042593 1 0.011
regulation of nervous system development GO:0051960 90 0.011
protein depolymerization GO:0051261 1 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.011
cytoplasm organization GO:0007028 4 0.011
zymogen activation GO:0031638 3 0.011
positive regulation of gliogenesis GO:0014015 2 0.011
pectoral fin development GO:0033339 50 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
positive regulation of molecular function GO:0044093 33 0.011
regulation of calcium ion transport GO:0051924 2 0.011
retina morphogenesis in camera type eye GO:0060042 79 0.011
striated muscle cell differentiation GO:0051146 129 0.011
apoptotic process GO:0006915 116 0.011
positive regulation of cell communication GO:0010647 56 0.011
cellular nitrogen compound metabolic process GO:0034641 290 0.011
cellular biosynthetic process GO:0044249 286 0.011
response to glucose GO:0009749 3 0.011
peptidyl serine modification GO:0018209 2 0.011
organic cyclic compound metabolic process GO:1901360 301 0.011
single organism cell adhesion GO:0098602 29 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.011
protein complex disassembly GO:0043241 1 0.011
tube closure GO:0060606 1 0.011
regulation of carbohydrate metabolic process GO:0006109 4 0.011
smooth muscle contraction GO:0006939 2 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
negative regulation of protein transport GO:0051224 3 0.010
gtp catabolic process GO:0006184 2 0.010
positive regulation of cell motility GO:2000147 11 0.010
epithelial cell differentiation GO:0030855 116 0.010
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.010
determination of left right symmetry GO:0007368 179 0.010
multi organism process GO:0051704 134 0.010
sequestering of calcium ion GO:0051208 3 0.010
regulation of axonogenesis GO:0050770 32 0.010
negative regulation of cell death GO:0060548 60 0.010
heart contraction GO:0060047 71 0.010
regulation of growth GO:0040008 42 0.010
embryonic pattern specification GO:0009880 44 0.010
multi organism cellular process GO:0044764 2 0.010
regulation of rna metabolic process GO:0051252 224 0.010
regulation of cell cycle GO:0051726 52 0.010
liver development GO:0001889 96 0.010
negative regulation of cell proliferation GO:0008285 8 0.010
cation transport GO:0006812 81 0.010
sex determination GO:0007530 1 0.010

pde10a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.026
cancer DOID:162 0 0.017
organ system cancer DOID:0050686 0 0.012
disease of anatomical entity DOID:7 0 0.012
musculoskeletal system disease DOID:17 0 0.012