Danio rerio

0 known processes

pdpk1a

3-phosphoinositide dependent protein kinase-1a

(Aliases: zgc:153787)

pdpk1a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
immune system process GO:0002376 241 0.110
regulation of establishment of protein localization GO:0070201 4 0.105
aging GO:0007568 2 0.100
response to biotic stimulus GO:0009607 97 0.100
hemopoiesis GO:0030097 183 0.079
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.072
immune response GO:0006955 28 0.068
regulation of dna templated transcription in response to stress GO:0043620 0 0.066
cellular nitrogen compound metabolic process GO:0034641 290 0.062
response to stress GO:0006950 263 0.061
regulation of cytokine production GO:0001817 3 0.061
regulation of cell differentiation GO:0045595 142 0.061
homeostatic process GO:0042592 142 0.060
cellular response to chemical stimulus GO:0070887 157 0.058
phagocytosis GO:0006909 3 0.055
regulation of inflammatory response GO:0050727 2 0.054
aromatic compound biosynthetic process GO:0019438 217 0.052
cellular aromatic compound metabolic process GO:0006725 295 0.051
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.050
negative regulation of kinase activity GO:0033673 4 0.049
regulation of rna metabolic process GO:0051252 224 0.048
urogenital system development GO:0001655 97 0.047
homeostasis of number of cells GO:0048872 62 0.047
growth GO:0040007 174 0.046
striated muscle cell development GO:0055002 108 0.045
response to organic substance GO:0010033 153 0.045
hematopoietic or lymphoid organ development GO:0048534 191 0.044
nitrogen compound metabolic process GO:0006807 319 0.044
organic cyclic compound metabolic process GO:1901360 301 0.044
establishment of protein localization to plasma membrane GO:0090002 1 0.044
negative regulation of protein phosphorylation GO:0001933 4 0.043
response to uv GO:0009411 3 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.042
cellular nitrogen compound biosynthetic process GO:0044271 218 0.042
kidney development GO:0001822 92 0.041
embryonic skeletal joint morphogenesis GO:0060272 3 0.041
muscle structure development GO:0061061 196 0.041
heterocycle metabolic process GO:0046483 290 0.041
positive regulation of muscle cell differentiation GO:0051149 1 0.039
cellular macromolecule metabolic process GO:0044260 391 0.039
gland development GO:0048732 143 0.039
response to external stimulus GO:0009605 264 0.039
single organism metabolic process GO:0044710 217 0.039
microtubule organizing center organization GO:0031023 1 0.039
gtp metabolic process GO:0046039 4 0.038
positive regulation of transport GO:0051050 2 0.037
regulation of cellular metabolic process GO:0031323 320 0.037
regulation of nitrogen compound metabolic process GO:0051171 251 0.037
organic cyclic compound biosynthetic process GO:1901362 223 0.037
regulation of protein transport GO:0051223 3 0.036
regulation of microtubule cytoskeleton organization GO:0070507 3 0.036
nucleic acid metabolic process GO:0090304 244 0.035
defense response GO:0006952 47 0.035
cellular component biogenesis GO:0044085 178 0.034
larval development GO:0002164 2 0.033
locomotion GO:0040011 313 0.033
skeletal system morphogenesis GO:0048705 102 0.033
guanosine containing compound metabolic process GO:1901068 4 0.033
centrosome organization GO:0051297 1 0.033
nucleobase containing compound metabolic process GO:0006139 274 0.033
heterocycle biosynthetic process GO:0018130 215 0.032
response to wounding GO:0009611 116 0.031
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.031
multicellular organismal metabolic process GO:0044236 2 0.030
phosphorylation GO:0016310 69 0.030
antimicrobial humoral response GO:0019730 2 0.029
regulation of multicellular organism growth GO:0040014 4 0.029
positive regulation of dna metabolic process GO:0051054 1 0.029
muscle cell differentiation GO:0042692 139 0.029
response to external biotic stimulus GO:0043207 97 0.029
embryonic skeletal joint development GO:0072498 3 0.028
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.028
guanosine containing compound catabolic process GO:1901069 2 0.028
morphogenesis of an epithelium GO:0002009 333 0.028
regulation of stem cell differentiation GO:2000736 4 0.027
response to hexose GO:0009746 3 0.027
cell surface receptor signaling pathway GO:0007166 325 0.027
regulation of protein localization to nucleus GO:1900180 2 0.027
blood vessel morphogenesis GO:0048514 216 0.027
modification dependent protein catabolic process GO:0019941 3 0.027
regulation of synapse organization GO:0050807 3 0.027
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.027
regulation of cell development GO:0060284 100 0.026
cellular localization GO:0051641 97 0.026
cell projection organization GO:0030030 284 0.026
proteasomal protein catabolic process GO:0010498 2 0.025
negative regulation of secretion by cell GO:1903531 2 0.025
biosynthetic process GO:0009058 294 0.024
cellular component movement GO:0006928 335 0.024
regulation of metabolic process GO:0019222 359 0.024
immune system development GO:0002520 191 0.024
system process GO:0003008 185 0.024
renal system development GO:0072001 94 0.024
ovarian follicle development GO:0001541 2 0.024
cellular biosynthetic process GO:0044249 286 0.024
positive regulation of cell cycle GO:0045787 3 0.023
cell migration GO:0016477 237 0.023
fatty acid oxidation GO:0019395 1 0.023
signal transduction GO:0007165 455 0.023
tissue regeneration GO:0042246 74 0.023
cell part morphogenesis GO:0032990 246 0.023
pharyngeal muscle development GO:0043282 4 0.023
organic substance biosynthetic process GO:1901576 289 0.022
angiogenesis GO:0001525 158 0.022
erythrocyte homeostasis GO:0034101 55 0.022
neuron development GO:0048666 262 0.022
regulation of gene expression GO:0010468 265 0.021
oxoacid metabolic process GO:0043436 31 0.021
response to corticosteroid GO:0031960 1 0.021
ubiquitin dependent protein catabolic process GO:0006511 3 0.021
myeloid cell differentiation GO:0030099 86 0.021
regulation of biological quality GO:0065008 263 0.021
osteoclast differentiation GO:0030316 1 0.021
embryo development ending in birth or egg hatching GO:0009792 271 0.020
maintenance of location GO:0051235 4 0.020
carboxylic acid metabolic process GO:0019752 22 0.020
regulation of dendrite development GO:0050773 3 0.020
peptidyl serine phosphorylation GO:0018105 1 0.020
regulation of multicellular organismal development GO:2000026 223 0.020
convergent extension GO:0060026 118 0.020
multi organism process GO:0051704 134 0.020
developmental growth GO:0048589 166 0.020
vasculature development GO:0001944 278 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
negative regulation of nuclear division GO:0051784 3 0.020
embryonic skeletal system morphogenesis GO:0048704 93 0.020
nucleic acid templated transcription GO:0097659 181 0.019
positive regulation of cellular process GO:0048522 201 0.019
eye development GO:0001654 277 0.019
response to other organism GO:0051707 97 0.019
rna metabolic process GO:0016070 219 0.019
phosphorus metabolic process GO:0006793 109 0.019
erythrocyte differentiation GO:0030218 54 0.019
gene expression GO:0010467 252 0.019
rna biosynthetic process GO:0032774 181 0.019
establishment of synaptic vesicle localization GO:0097480 1 0.019
regulation of cellular biosynthetic process GO:0031326 245 0.019
cytoplasm organization GO:0007028 4 0.019
reactive oxygen species metabolic process GO:0072593 6 0.019
female sex differentiation GO:0046660 4 0.019
regulation of reproductive process GO:2000241 4 0.018
blood vessel development GO:0001568 246 0.018
determination of dorsal identity GO:0048263 13 0.018
cell proliferation GO:0008283 80 0.018
regulation of response to biotic stimulus GO:0002831 2 0.018
regulation of intracellular protein transport GO:0033157 3 0.018
centrosome duplication GO:0051298 1 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
wound healing GO:0042060 90 0.018
regulation of defense response GO:0031347 14 0.018
digestive tract development GO:0048565 265 0.018
negative regulation of protein kinase activity GO:0006469 4 0.017
cellular response to organic substance GO:0071310 105 0.017
cellular response to growth factor stimulus GO:0071363 39 0.017
stem cell maintenance GO:0019827 4 0.017
nucleobase containing compound biosynthetic process GO:0034654 205 0.017
positive regulation of catabolic process GO:0009896 4 0.017
central nervous system development GO:0007417 387 0.017
centrosome cycle GO:0007098 1 0.017
neurotransmitter transport GO:0006836 2 0.017
aorta development GO:0035904 4 0.017
response to abiotic stimulus GO:0009628 122 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
microtubule based process GO:0007017 60 0.017
negative regulation of response to stimulus GO:0048585 104 0.017
small gtpase mediated signal transduction GO:0007264 8 0.017
regulation of chromosome segregation GO:0051983 1 0.017
forebrain development GO:0030900 96 0.017
branching morphogenesis of a nerve GO:0048755 4 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.017
development of primary female sexual characteristics GO:0046545 4 0.016
regulation of rho protein signal transduction GO:0035023 2 0.016
regulation of primary metabolic process GO:0080090 311 0.016
gtp catabolic process GO:0006184 2 0.016
regulation of skeletal muscle fiber development GO:0048742 2 0.016
neuron differentiation GO:0030182 353 0.016
regulation of neurogenesis GO:0050767 87 0.016
macromolecule biosynthetic process GO:0009059 227 0.016
regeneration GO:0031099 91 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
positive regulation of cellular biosynthetic process GO:0031328 68 0.016
protein heterooligomerization GO:0051291 1 0.016
positive regulation of apoptotic signaling pathway GO:2001235 1 0.016
striated muscle cell differentiation GO:0051146 129 0.015
negative regulation of cell fate specification GO:0009996 11 0.015
rna localization GO:0006403 4 0.015
negative regulation of signaling GO:0023057 96 0.015
regulation of erk1 and erk2 cascade GO:0070372 4 0.015
cellular response to endogenous stimulus GO:0071495 68 0.015
response to organic cyclic compound GO:0014070 51 0.015
regulation of macromolecule metabolic process GO:0060255 317 0.015
cellular protein catabolic process GO:0044257 4 0.015
skeletal system development GO:0001501 181 0.015
response to chemical GO:0042221 320 0.015
regulation of meiotic cell cycle GO:0051445 1 0.015
regulation of cytokine mediated signaling pathway GO:0001959 3 0.015
positive regulation of metabolic process GO:0009893 108 0.015
negative regulation of cytokine production GO:0001818 1 0.015
negative regulation of translation GO:0017148 1 0.015
ovulation cycle process GO:0022602 2 0.014
sensory epithelium regeneration GO:0070654 14 0.014
regulation of organ growth GO:0046620 3 0.014
regulation of stem cell proliferation GO:0072091 2 0.014
cell morphogenesis involved in differentiation GO:0000904 195 0.014
positive regulation of nucleoside metabolic process GO:0045979 1 0.014
cellular response to radiation GO:0071478 4 0.014
muscle tissue development GO:0060537 110 0.014
single organism membrane fusion GO:0044801 2 0.014
cell aging GO:0007569 2 0.014
positive regulation of rna biosynthetic process GO:1902680 57 0.014
myeloid cell homeostasis GO:0002262 56 0.014
regulation of purine nucleotide catabolic process GO:0033121 2 0.014
regulation of cell proliferation GO:0042127 37 0.014
exocytosis GO:0006887 1 0.014
ribose phosphate metabolic process GO:0019693 27 0.014
negative regulation of map kinase activity GO:0043407 2 0.013
localization of cell GO:0051674 244 0.013
regulation of binding GO:0051098 3 0.013
p38mapk cascade GO:0038066 1 0.013
inner ear development GO:0048839 126 0.013
regulation of cellular response to oxidative stress GO:1900407 2 0.013
positive regulation of biological process GO:0048518 253 0.013
embryonic organ morphogenesis GO:0048562 274 0.013
cellular macromolecule biosynthetic process GO:0034645 224 0.013
regulation of mrna splicing via spliceosome GO:0048024 3 0.013
peripheral nervous system neuron differentiation GO:0048934 28 0.013
antibacterial humoral response GO:0019731 2 0.013
cytoskeleton organization GO:0007010 96 0.013
cellular response to reactive oxygen species GO:0034614 2 0.013
muscle cell development GO:0055001 115 0.013
regulation of macromolecule biosynthetic process GO:0010556 225 0.013
regulation of cell activation GO:0050865 1 0.012
cellular protein metabolic process GO:0044267 129 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
negative regulation of protein transport GO:0051224 3 0.012
protein localization to nucleus GO:0034504 3 0.012
regulation of rna biosynthetic process GO:2001141 213 0.012
regulation of mechanoreceptor differentiation GO:0045631 1 0.012
amine metabolic process GO:0009308 2 0.012
response to carbohydrate GO:0009743 3 0.012
startle response GO:0001964 4 0.012
negative regulation of defense response GO:0031348 2 0.012
branchiomotor neuron axon guidance GO:0021785 1 0.012
response to cold GO:0009409 4 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.012
negative regulation of ras protein signal transduction GO:0046580 1 0.012
intracellular signal transduction GO:0035556 85 0.012
regulation of protein binding GO:0043393 3 0.012
nephron tubule morphogenesis GO:0072078 1 0.012
chordate embryonic development GO:0043009 271 0.012
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
organonitrogen compound metabolic process GO:1901564 74 0.011
ovulation cycle GO:0042698 2 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
negative regulation of cell communication GO:0010648 96 0.011
organic acid metabolic process GO:0006082 31 0.011
cell motility GO:0048870 244 0.011
protein metabolic process GO:0019538 183 0.011
positive regulation of immune effector process GO:0002699 3 0.011
negative regulation of multi organism process GO:0043901 3 0.011
interaction with host GO:0051701 4 0.011
mitochondrial transport GO:0006839 2 0.011
phagocytosis engulfment GO:0006911 1 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
lymphocyte proliferation GO:0046651 1 0.011
peptidyl serine modification GO:0018209 2 0.011
negative regulation of feeding behavior GO:2000252 2 0.011
tissue remodeling GO:0048771 4 0.011
regulation of dna recombination GO:0000018 2 0.011
positive regulation of multi organism process GO:0043902 3 0.011
positive regulation of cellular metabolic process GO:0031325 94 0.011
negative regulation of secretion GO:0051048 2 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
regulation of gtpase activity GO:0043087 2 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
regulation of cell maturation GO:1903429 1 0.011
locomotor rhythm GO:0045475 3 0.011
regulation of signaling GO:0023051 235 0.011
autophagy GO:0006914 4 0.011
ribosomal small subunit biogenesis GO:0042274 2 0.011
phosphatidylinositol mediated signaling GO:0048015 2 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.011
long chain fatty acid transport GO:0015909 1 0.011
protein modification process GO:0036211 100 0.010
cell aggregation GO:0098743 3 0.010
xenobiotic metabolic process GO:0006805 4 0.010
response to growth factor GO:0070848 39 0.010
regulation of jak stat cascade GO:0046425 3 0.010
regulation of dna replication GO:0006275 3 0.010
nephron tubule epithelial cell differentiation GO:0072160 1 0.010
positive regulation of signal transduction GO:0009967 56 0.010
negative regulation of stem cell differentiation GO:2000737 2 0.010
protein stabilization GO:0050821 2 0.010
regulation of multicellular organismal process GO:0051239 277 0.010
response to bacterium GO:0009617 58 0.010
regulation of response to stimulus GO:0048583 269 0.010
regulation of cell cycle GO:0051726 52 0.010
cell cycle g2 m phase transition GO:0044839 4 0.010
developmental growth involved in morphogenesis GO:0060560 86 0.010
lipid oxidation GO:0034440 1 0.010
regulation of phosphorus metabolic process GO:0051174 43 0.010

pdpk1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.014
disease of anatomical entity DOID:7 0 0.013
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011