Danio rerio

0 known processes

penka

proenkephalin a

(Aliases: penkl,zgc:73353)

penka biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular nitrogen compound biosynthetic process GO:0044271 218 0.258
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.251
cellular aromatic compound metabolic process GO:0006725 295 0.246
cell surface receptor signaling pathway GO:0007166 325 0.232
nucleobase containing compound biosynthetic process GO:0034654 205 0.198
aromatic compound biosynthetic process GO:0019438 217 0.191
regulation of nitrogen compound metabolic process GO:0051171 251 0.183
organic cyclic compound biosynthetic process GO:1901362 223 0.181
regulation of cellular metabolic process GO:0031323 320 0.180
regulation of catalytic activity GO:0050790 55 0.176
organic substance biosynthetic process GO:1901576 289 0.168
organic cyclic compound metabolic process GO:1901360 301 0.163
regulation of ion transmembrane transporter activity GO:0032412 2 0.157
gene expression GO:0010467 252 0.153
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 5 0.151
biosynthetic process GO:0009058 294 0.141
rna biosynthetic process GO:0032774 181 0.130
nucleobase containing compound metabolic process GO:0006139 274 0.129
nitrogen compound metabolic process GO:0006807 319 0.125
cellular nitrogen compound metabolic process GO:0034641 290 0.124
adult behavior GO:0030534 2 0.122
regulation of metabolic process GO:0019222 359 0.118
cognition GO:0050890 1 0.117
cellular component morphogenesis GO:0032989 336 0.112
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 5 0.111
nucleic acid metabolic process GO:0090304 244 0.110
heterocycle metabolic process GO:0046483 290 0.109
cell projection organization GO:0030030 284 0.108
cellular macromolecule metabolic process GO:0044260 391 0.106
negative regulation of biological process GO:0048519 304 0.104
signal transduction GO:0007165 455 0.103
rna metabolic process GO:0016070 219 0.103
regulation of biosynthetic process GO:0009889 250 0.100
regulation of cellular biosynthetic process GO:0031326 245 0.099
cellular protein metabolic process GO:0044267 129 0.096
cellular amine metabolic process GO:0044106 2 0.092
heterocycle biosynthetic process GO:0018130 215 0.089
positive regulation of transport GO:0051050 2 0.089
localization of cell GO:0051674 244 0.087
glutamate receptor signaling pathway GO:0007215 1 0.086
larval development GO:0002164 2 0.083
regulation of macromolecule metabolic process GO:0060255 317 0.081
g protein coupled receptor signaling pathway GO:0007186 74 0.080
regulation of transporter activity GO:0032409 2 0.079
dopamine metabolic process GO:0042417 2 0.076
regulation of primary metabolic process GO:0080090 311 0.074
regulation of transmembrane transporter activity GO:0022898 2 0.072
amine metabolic process GO:0009308 2 0.071
positive regulation of cellular process GO:0048522 201 0.071
regulation of reproductive process GO:2000241 4 0.067
regulation of gene expression GO:0010468 265 0.066
transcription from rna polymerase ii promoter GO:0006366 80 0.066
regulation of response to stimulus GO:0048583 269 0.065
establishment of localization GO:0051234 244 0.065
positive regulation of camp metabolic process GO:0030816 2 0.064
cellular macromolecule biosynthetic process GO:0034645 224 0.063
regulation of localization GO:0032879 104 0.063
response to amine GO:0014075 1 0.062
catechol containing compound metabolic process GO:0009712 2 0.061
sensory organ development GO:0007423 393 0.061
nucleoside phosphate biosynthetic process GO:1901293 21 0.060
ion transport GO:0006811 114 0.059
organonitrogen compound biosynthetic process GO:1901566 47 0.059
organonitrogen compound metabolic process GO:1901564 74 0.057
neuron projection morphogenesis GO:0048812 161 0.057
negative regulation of cellular process GO:0048523 283 0.056
regulation of cytoplasmic transport GO:1903649 4 0.056
response to chemical GO:0042221 320 0.056
locomotion GO:0040011 313 0.055
regulation of phosphate metabolic process GO:0019220 43 0.054
negative regulation of molecular function GO:0044092 23 0.054
regulation of transmembrane transport GO:0034762 18 0.053
neuron neuron synaptic transmission GO:0007270 1 0.053
regulation of signaling GO:0023051 235 0.053
nucleic acid templated transcription GO:0097659 181 0.052
regulation of transcription dna templated GO:0006355 213 0.052
regulation of calcium ion transport GO:0051924 2 0.050
regulation of ion transport GO:0043269 22 0.050
single organism localization GO:1902578 225 0.049
macromolecule modification GO:0043412 111 0.049
nucleotide biosynthetic process GO:0009165 21 0.048
regulation of multicellular organismal process GO:0051239 277 0.048
regulation of cellular amine metabolic process GO:0033238 0 0.047
cell part morphogenesis GO:0032990 246 0.047
regulation of macromolecule biosynthetic process GO:0010556 225 0.046
cyclic nucleotide biosynthetic process GO:0009190 18 0.046
negative regulation of metabolic process GO:0009892 86 0.046
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.045
positive regulation of biological process GO:0048518 253 0.045
regulation of lyase activity GO:0051339 12 0.044
positive regulation of metabolic process GO:0009893 108 0.044
response to amphetamine GO:0001975 1 0.044
eye development GO:0001654 277 0.043
regulation of rna metabolic process GO:0051252 224 0.043
inner ear development GO:0048839 126 0.042
cellular biosynthetic process GO:0044249 286 0.042
regulation of signal transduction GO:0009966 225 0.041
generation of neurons GO:0048699 385 0.041
protein modification process GO:0036211 100 0.041
response to organic substance GO:0010033 153 0.041
neuron projection development GO:0031175 180 0.040
macromolecule biosynthetic process GO:0009059 227 0.040
single organism transport GO:0044765 206 0.039
dopaminergic neuron differentiation GO:0071542 14 0.039
regulation of rna biosynthetic process GO:2001141 213 0.039
purine ribonucleotide biosynthetic process GO:0009152 20 0.039
response to endogenous stimulus GO:0009719 83 0.039
catecholamine metabolic process GO:0006584 2 0.039
regulation of dendrite development GO:0050773 3 0.039
mechanosensory lateral line system development GO:0048881 49 0.038
regulation of cyclase activity GO:0031279 12 0.038
regulation of protein transport GO:0051223 3 0.038
regulation of cell communication GO:0010646 232 0.038
response to abiotic stimulus GO:0009628 122 0.038
locomotory behavior GO:0007626 34 0.038
Mouse
regulation of receptor activity GO:0010469 2 0.037
regulation of protein localization to nucleus GO:1900180 2 0.036
phagocytosis GO:0006909 3 0.036
regulation of intracellular protein transport GO:0033157 3 0.036
regulation of ion transmembrane transport GO:0034765 18 0.035
regulation of nucleocytoplasmic transport GO:0046822 2 0.035
regulation of transport GO:0051049 45 0.035
cell projection morphogenesis GO:0048858 244 0.034
establishment of protein localization to organelle GO:0072594 4 0.034
regulation of establishment of protein localization GO:0070201 4 0.034
positive regulation of gene expression GO:0010628 71 0.033
regulation of nucleotide biosynthetic process GO:0030808 15 0.033
nucleocytoplasmic transport GO:0006913 4 0.033
metal ion transport GO:0030001 58 0.033
regulation of developmental process GO:0050793 247 0.033
regulation of nucleic acid templated transcription GO:1903506 213 0.033
cell morphogenesis GO:0000902 289 0.032
regulation of locomotion GO:0040012 55 0.032
sensory system development GO:0048880 76 0.032
protein targeting to nucleus GO:0044744 3 0.032
nuclear transport GO:0051169 4 0.032
regulation of metal ion transport GO:0010959 4 0.031
chemotaxis GO:0006935 104 0.031
positive regulation of cellular metabolic process GO:0031325 94 0.031
nuclear import GO:0051170 3 0.031
regulation of cyclic nucleotide biosynthetic process GO:0030802 15 0.031
regulation of nucleotide metabolic process GO:0006140 17 0.031
purine nucleotide biosynthetic process GO:0006164 20 0.030
ear development GO:0043583 127 0.030
regulation of adenylate cyclase activity GO:0045761 6 0.030
neuron differentiation GO:0030182 353 0.030
negative regulation of catabolic process GO:0009895 3 0.030
regionalization GO:0003002 274 0.030
regulation of cellular amino acid metabolic process GO:0006521 0 0.030
regulation of protein import into nucleus GO:0042306 2 0.030
response to light stimulus GO:0009416 46 0.030
cation transport GO:0006812 81 0.030
transport GO:0006810 220 0.030
purine containing compound biosynthetic process GO:0072522 20 0.030
directional locomotion GO:0033058 1 0.030
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.029
camp metabolic process GO:0046058 11 0.029
regulation of molecular function GO:0065009 70 0.029
organelle organization GO:0006996 227 0.029
phosphorus metabolic process GO:0006793 109 0.029
positive regulation of camp biosynthetic process GO:0030819 2 0.029
lateral line system development GO:0048925 76 0.028
single organism nuclear import GO:1902593 3 0.028
ribonucleotide biosynthetic process GO:0009260 20 0.028
multicellular organism growth GO:0035264 4 0.028
cell differentiation in spinal cord GO:0021515 40 0.028
cellular ketone metabolic process GO:0042180 11 0.028
regulation of cellular ketone metabolic process GO:0010565 7 0.028
regulation of neurogenesis GO:0050767 87 0.028
chemosensory behavior GO:0007635 1 0.027
regulation of camp biosynthetic process GO:0030817 9 0.027
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.027
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.027
regulation of multicellular organismal development GO:2000026 223 0.026
positive regulation of cellular component biogenesis GO:0044089 3 0.026
neurological system process GO:0050877 62 0.026
Mouse
cellular amino acid metabolic process GO:0006520 7 0.026
gastrulation GO:0007369 208 0.026
positive regulation of biosynthetic process GO:0009891 68 0.026
protein localization to nucleus GO:0034504 3 0.026
camp biosynthetic process GO:0006171 11 0.026
morphogenesis of an epithelium GO:0002009 333 0.025
cell migration GO:0016477 237 0.025
neuron development GO:0048666 262 0.025
positive regulation of cellular amine metabolic process GO:0033240 0 0.025
regulation of cyclic nucleotide metabolic process GO:0030799 15 0.025
cellular component biogenesis GO:0044085 178 0.025
embryonic organ development GO:0048568 381 0.025
cellular component movement GO:0006928 335 0.025
catechol containing compound biosynthetic process GO:0009713 2 0.025
aging GO:0007568 2 0.024
peptidyl serine modification GO:0018209 2 0.024
negative regulation of protein kinase activity GO:0006469 4 0.024
carboxylic acid metabolic process GO:0019752 22 0.024
transmembrane transport GO:0055085 120 0.024
hormone secretion GO:0046879 2 0.024
transcription dna templated GO:0006351 181 0.024
central nervous system neuron axonogenesis GO:0021955 18 0.024
lateral line development GO:0048882 66 0.024
negative regulation of protein phosphorylation GO:0001933 4 0.024
behavior GO:0007610 74 0.024
Mouse
diencephalon development GO:0021536 58 0.024
cell motility GO:0048870 244 0.024
protein import GO:0017038 3 0.024
protein import into nucleus GO:0006606 3 0.023
regulation of cell development GO:0060284 100 0.023
retina development in camera type eye GO:0060041 146 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.023
regulation of synapse organization GO:0050807 3 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.023
head development GO:0060322 303 0.022
cell morphogenesis involved in differentiation GO:0000904 195 0.022
sleep GO:0030431 1 0.022
single organism metabolic process GO:0044710 217 0.022
mitochondrion organization GO:0007005 4 0.022
central nervous system development GO:0007417 387 0.022
regulation of purine nucleotide biosynthetic process GO:1900371 15 0.022
ribose phosphate biosynthetic process GO:0046390 20 0.022
phosphate containing compound metabolic process GO:0006796 108 0.022
endocrine system development GO:0035270 65 0.021
posterior lateral line system development GO:0048915 46 0.021
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.021
positive regulation of catabolic process GO:0009896 4 0.021
developmental maturation GO:0021700 34 0.021
regulation of cell death GO:0010941 103 0.021
positive regulation of signaling GO:0023056 56 0.021
response to glucose GO:0009749 3 0.021
regulation of phosphorus metabolic process GO:0051174 43 0.020
tube morphogenesis GO:0035239 349 0.020
neuroblast proliferation GO:0007405 2 0.020
central nervous system neuron differentiation GO:0021953 74 0.020
oxoacid metabolic process GO:0043436 31 0.020
organic acid metabolic process GO:0006082 31 0.020
single organism biosynthetic process GO:0044711 71 0.020
neuron projection extension GO:1990138 45 0.020
regulation of cell differentiation GO:0045595 142 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
catecholamine biosynthetic process GO:0042423 2 0.020
hormone transport GO:0009914 2 0.019
regulation of anatomical structure morphogenesis GO:0022603 130 0.019
carbohydrate derivative biosynthetic process GO:1901137 43 0.019
negative regulation of protein transport GO:0051224 3 0.019
calcium ion transport GO:0006816 18 0.019
positive regulation of macromolecule metabolic process GO:0010604 93 0.019
central nervous system neuron development GO:0021954 29 0.019
cellular amide metabolic process GO:0043603 4 0.019
carbohydrate homeostasis GO:0033500 1 0.019
compound eye development GO:0048749 2 0.019
positive regulation of cell communication GO:0010647 56 0.019
negative regulation of catalytic activity GO:0043086 21 0.019
maintenance of location GO:0051235 4 0.018
cellular response to radiation GO:0071478 4 0.018
dorsal ventral pattern formation GO:0009953 125 0.018
anterior posterior pattern specification GO:0009952 152 0.018
multicellular organismal response to stress GO:0033555 2 0.018
Mouse
response to carbohydrate GO:0009743 3 0.018
proteasomal protein catabolic process GO:0010498 2 0.018
regulation of hormone secretion GO:0046883 2 0.018
negative regulation of gene expression GO:0010629 65 0.018
positive regulation of nucleic acid templated transcription GO:1903508 57 0.018
cellular localization GO:0051641 97 0.018
cellular protein modification process GO:0006464 100 0.018
brain development GO:0007420 293 0.018
positive regulation of rna metabolic process GO:0051254 59 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.018
camera type eye development GO:0043010 222 0.017
guanosine containing compound catabolic process GO:1901069 2 0.017
cellular component assembly GO:0022607 170 0.017
positive regulation of cell cycle GO:0045787 3 0.017
modification dependent macromolecule catabolic process GO:0043632 3 0.017
cellular response to light stimulus GO:0071482 4 0.017
regulation of purine nucleotide metabolic process GO:1900542 17 0.017
alpha amino acid metabolic process GO:1901605 3 0.017
calcium ion transmembrane transport GO:0070588 13 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
cellular protein catabolic process GO:0044257 4 0.017
regulation of oligodendrocyte differentiation GO:0048713 1 0.017
negative regulation of macromolecule metabolic process GO:0010605 76 0.017
ion transmembrane transport GO:0034220 91 0.017
muscle structure development GO:0061061 196 0.017
establishment of synaptic vesicle localization GO:0097480 1 0.016
single organism behavior GO:0044708 24 0.016
Mouse
neuromuscular process controlling balance GO:0050885 3 0.016
cellular component disassembly GO:0022411 1 0.016
response to ketone GO:1901654 1 0.016
ubiquitin dependent protein catabolic process GO:0006511 3 0.016
response to hexose GO:0009746 3 0.016
negative regulation of cellular metabolic process GO:0031324 77 0.016
peptide transport GO:0015833 1 0.016
positive regulation of molecular function GO:0044093 33 0.016
protein metabolic process GO:0019538 183 0.016
positive regulation of purine nucleotide biosynthetic process GO:1900373 8 0.016
regulation of jak stat cascade GO:0046425 3 0.016
gtp metabolic process GO:0046039 4 0.016
negative regulation of kinase activity GO:0033673 4 0.015
intracellular signal transduction GO:0035556 85 0.015
macromolecular complex disassembly GO:0032984 1 0.015
single organism cellular localization GO:1902580 46 0.015
negative regulation of gliogenesis GO:0014014 1 0.015
divalent inorganic cation transport GO:0072511 21 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.015
taxis GO:0042330 109 0.015
axon development GO:0061564 166 0.015
negative regulation of sequestering of calcium ion GO:0051283 4 0.015
positive regulation of secretion GO:0051047 1 0.015
regulation of dendrite morphogenesis GO:0048814 3 0.015
axon extension GO:0048675 45 0.015
maternal determination of anterior posterior axis embryo GO:0008358 4 0.015
regulation of synapse assembly GO:0051963 3 0.015
spinal cord motor neuron differentiation GO:0021522 26 0.015
interspecies interaction between organisms GO:0044419 4 0.015
phosphorylation GO:0016310 69 0.015
regulation of binding GO:0051098 3 0.015
negative regulation of cell communication GO:0010648 96 0.015
membrane invagination GO:0010324 1 0.015
monoamine transport GO:0015844 1 0.015
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.015
regulation of synaptic plasticity GO:0048167 1 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
positive regulation of map kinase activity GO:0043406 3 0.014
regulation of membrane potential GO:0042391 23 0.014
renal system development GO:0072001 94 0.014
synaptic growth at neuromuscular junction GO:0051124 2 0.014
establishment of localization in cell GO:0051649 77 0.014
response to external stimulus GO:0009605 264 0.014
Mouse
regulation of multicellular organism growth GO:0040014 4 0.014
regulation of biological quality GO:0065008 263 0.014
small molecule catabolic process GO:0044282 3 0.014
positive regulation of response to stimulus GO:0048584 80 0.014
positive regulation of cellular catabolic process GO:0031331 3 0.014
cellular response to extracellular stimulus GO:0031668 2 0.014
meiotic nuclear division GO:0007126 4 0.014
gland development GO:0048732 143 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.014
regulation of glial cell differentiation GO:0045685 4 0.014
developmental cell growth GO:0048588 52 0.014
organophosphate metabolic process GO:0019637 37 0.014
regulation of protein targeting GO:1903533 2 0.014
neuron migration GO:0001764 22 0.014
regulation of cytokine production GO:0001817 3 0.014
developmental growth GO:0048589 166 0.014
modification dependent protein catabolic process GO:0019941 3 0.013
regulation of protein catabolic process GO:0042176 1 0.013
regulation of cell shape GO:0008360 1 0.013
homeostatic process GO:0042592 142 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
response to hormone GO:0009725 48 0.013
positive regulation of rna biosynthetic process GO:1902680 57 0.013
small molecule metabolic process GO:0044281 77 0.013
organophosphate biosynthetic process GO:0090407 23 0.013
membrane hyperpolarization GO:0060081 1 0.013
gabaergic neuron differentiation GO:0097154 2 0.013
regulation of nervous system development GO:0051960 90 0.013
response to food GO:0032094 1 0.013
heart development GO:0007507 313 0.013
water homeostasis GO:0030104 4 0.013
development of primary female sexual characteristics GO:0046545 4 0.013
protein phosphorylation GO:0006468 47 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
regulation of circadian rhythm GO:0042752 4 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.012
autophagy GO:0006914 4 0.012
sequestering of metal ion GO:0051238 3 0.012
positive regulation of transcription dna templated GO:0045893 57 0.012
protein stabilization GO:0050821 2 0.012
regulation of neuron differentiation GO:0045664 56 0.012
cyclic nucleotide metabolic process GO:0009187 18 0.012
digestive system development GO:0055123 289 0.012
axonogenesis GO:0007409 152 0.012
sensory perception of chemical stimulus GO:0007606 3 0.012
stem cell proliferation GO:0072089 4 0.012
system process GO:0003008 185 0.012
Mouse
liver development GO:0001889 96 0.012
regulation of neuron projection development GO:0010975 40 0.012
negative regulation of reproductive process GO:2000242 3 0.012
mesenchymal cell differentiation GO:0048762 87 0.012
convergent extension GO:0060026 118 0.012
regulation of sequestering of calcium ion GO:0051282 4 0.012
regulation of inflammatory response GO:0050727 2 0.011
growth GO:0040007 174 0.011
guanosine containing compound metabolic process GO:1901068 4 0.011
photoreceptor cell development GO:0042461 40 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
chordate embryonic development GO:0043009 271 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
cellular response to endogenous stimulus GO:0071495 68 0.011
death GO:0016265 121 0.011
divalent metal ion transport GO:0070838 20 0.011
synaptic transmission GO:0007268 35 0.011
skeletal system development GO:0001501 181 0.011
cellular response to external stimulus GO:0071496 2 0.011
cation transmembrane transport GO:0098655 65 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
positive regulation of nucleotide biosynthetic process GO:0030810 8 0.011
response to monosaccharide GO:0034284 3 0.011
spinal cord development GO:0021510 46 0.011
multi organism cellular process GO:0044764 2 0.011
regulation of programmed cell death GO:0043067 101 0.011
antimicrobial humoral response GO:0019730 2 0.011
regulation of erk1 and erk2 cascade GO:0070372 4 0.011
positive regulation of lyase activity GO:0051349 6 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.010
axon guidance GO:0007411 86 0.010
positive regulation of cyclase activity GO:0031281 6 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
neurotransmitter secretion GO:0007269 2 0.010
regulation of cellular component organization GO:0051128 86 0.010
inorganic ion transmembrane transport GO:0098660 57 0.010
phenol containing compound biosynthetic process GO:0046189 4 0.010
extrinsic apoptotic signaling pathway GO:0097191 3 0.010
sequestering of calcium ion GO:0051208 3 0.010
response to alkaloid GO:0043279 2 0.010
neurotransmitter transport GO:0006836 2 0.010
regulation of cell substrate adhesion GO:0010810 1 0.010
synaptic vesicle localization GO:0097479 1 0.010
phenol containing compound metabolic process GO:0018958 5 0.010

penka disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.031
nervous system disease DOID:863 0 0.017
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
disease of metabolism DOID:0014667 0 0.011