Danio rerio

0 known processes

pfn2l

profilin 2 like

(Aliases: wu:fb02e10,zgc:86790,hm:zeh0341,wu:fi35b08)

pfn2l biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
pronuclear migration GO:0035046 1 0.675
larval development GO:0002164 2 0.475
neuron differentiation GO:0030182 353 0.251
heterocycle metabolic process GO:0046483 290 0.251
cell projection organization GO:0030030 284 0.246
regulation of gene expression GO:0010468 265 0.245
organic substance biosynthetic process GO:1901576 289 0.225
organic cyclic compound metabolic process GO:1901360 301 0.220
nuclear migration GO:0007097 3 0.219
fertilization GO:0009566 3 0.197
cellular biosynthetic process GO:0044249 286 0.193
cellular component biogenesis GO:0044085 178 0.190
Rat
gene expression GO:0010467 252 0.181
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.169
biosynthetic process GO:0009058 294 0.153
central nervous system development GO:0007417 387 0.152
regulation of metabolic process GO:0019222 359 0.135
macromolecule biosynthetic process GO:0009059 227 0.132
establishment of localization GO:0051234 244 0.129
autophagy GO:0006914 4 0.128
cell morphogenesis GO:0000902 289 0.126
regulation of protein catabolic process GO:0042176 1 0.126
negative regulation of biological process GO:0048519 304 0.124
establishment of organelle localization GO:0051656 45 0.120
nitrogen compound metabolic process GO:0006807 319 0.120
single fertilization GO:0007338 3 0.113
establishment of nucleus localization GO:0040023 7 0.111
regulation of cell differentiation GO:0045595 142 0.110
striated muscle cell differentiation GO:0051146 129 0.109
cellular macromolecule biosynthetic process GO:0034645 224 0.108
cell cycle g2 m phase transition GO:0044839 4 0.107
cytokinesis GO:0000910 3 0.100
generation of neurons GO:0048699 385 0.100
endosomal transport GO:0016197 2 0.100
regulation of establishment of protein localization GO:0070201 4 0.096
cytoskeleton dependent cytokinesis GO:0061640 3 0.093
protein secretion GO:0009306 1 0.093
positive regulation of transport GO:0051050 2 0.092
organelle localization GO:0051640 49 0.088
brain development GO:0007420 293 0.086
small molecule metabolic process GO:0044281 77 0.084
head development GO:0060322 303 0.084
cortical cytoskeleton organization GO:0030865 1 0.083
cellular component movement GO:0006928 335 0.083
regulation of biosynthetic process GO:0009889 250 0.082
nucleobase containing compound metabolic process GO:0006139 274 0.082
cellular component assembly GO:0022607 170 0.082
Rat
negative regulation of cellular process GO:0048523 283 0.079
neuron development GO:0048666 262 0.078
cell death GO:0008219 121 0.076
response to external stimulus GO:0009605 264 0.075
signal transduction GO:0007165 455 0.074
taxis GO:0042330 109 0.073
protein localization to plasma membrane GO:0072659 1 0.070
regulation of cellular biosynthetic process GO:0031326 245 0.069
growth GO:0040007 174 0.069
apoptotic process GO:0006915 116 0.068
death GO:0016265 121 0.068
aging GO:0007568 2 0.067
cell migration GO:0016477 237 0.067
cell projection morphogenesis GO:0048858 244 0.067
multi organism process GO:0051704 134 0.066
multicellular organism growth GO:0035264 4 0.065
locomotion GO:0040011 313 0.065
muscle structure development GO:0061061 196 0.065
programmed cell death GO:0012501 119 0.064
regulation of cell communication GO:0010646 232 0.063
positive regulation of biological process GO:0048518 253 0.062
regulation of macromolecule metabolic process GO:0060255 317 0.062
regulation of rna biosynthetic process GO:2001141 213 0.062
regulation of biological quality GO:0065008 263 0.061
Rat
regulation of nitrogen compound metabolic process GO:0051171 251 0.061
negative regulation of gene expression GO:0010629 65 0.060
protein metabolic process GO:0019538 183 0.060
ubiquitin dependent protein catabolic process GO:0006511 3 0.059
cell surface receptor signaling pathway GO:0007166 325 0.059
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.058
neuron projection development GO:0031175 180 0.058
cellular protein metabolic process GO:0044267 129 0.058
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.057
guanosine containing compound metabolic process GO:1901068 4 0.057
ribonucleoside monophosphate catabolic process GO:0009158 4 0.057
regulation of cell development GO:0060284 100 0.056
regionalization GO:0003002 274 0.056
developmental growth GO:0048589 166 0.056
exocytosis GO:0006887 1 0.056
cell part morphogenesis GO:0032990 246 0.056
cellular component morphogenesis GO:0032989 336 0.056
regulation of cytoplasmic transport GO:1903649 4 0.055
regulation of cellular metabolic process GO:0031323 320 0.054
regulation of protein transport GO:0051223 3 0.053
negative regulation of metabolic process GO:0009892 86 0.052
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.052
guanosine containing compound catabolic process GO:1901069 2 0.052
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.052
cellular protein complex assembly GO:0043623 19 0.051
Rat
axon development GO:0061564 166 0.050
cellular protein catabolic process GO:0044257 4 0.050
specification of symmetry GO:0009799 204 0.050
transcription dna templated GO:0006351 181 0.049
regulation of embryonic development GO:0045995 47 0.049
positive regulation of carbohydrate metabolic process GO:0045913 1 0.049
positive regulation of secretion by cell GO:1903532 1 0.048
negative regulation of cytoplasmic transport GO:1903650 2 0.048
positive regulation of catabolic process GO:0009896 4 0.048
phagocytosis GO:0006909 3 0.048
protein modification by small protein removal GO:0070646 1 0.047
regulation of cell shape GO:0008360 1 0.046
positive regulation of cellular component biogenesis GO:0044089 3 0.044
gtp metabolic process GO:0046039 4 0.044
regulation of developmental process GO:0050793 247 0.044
cellular nitrogen compound biosynthetic process GO:0044271 218 0.043
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.042
protein stabilization GO:0050821 2 0.042
regulation of protein ubiquitination GO:0031396 3 0.042
rna metabolic process GO:0016070 219 0.042
axon guidance GO:0007411 86 0.042
negative regulation of response to stimulus GO:0048585 104 0.042
maintenance of location GO:0051235 4 0.041
regulation of multicellular organismal process GO:0051239 277 0.041
cellular nitrogen compound metabolic process GO:0034641 290 0.041
positive regulation of secretion GO:0051047 1 0.041
embryo development ending in birth or egg hatching GO:0009792 271 0.041
single organism localization GO:1902578 225 0.040
gtp catabolic process GO:0006184 2 0.040
axonogenesis GO:0007409 152 0.039
carbohydrate biosynthetic process GO:0016051 1 0.038
rna biosynthetic process GO:0032774 181 0.037
nucleobase containing compound biosynthetic process GO:0034654 205 0.037
cellular macromolecule metabolic process GO:0044260 391 0.037
maternal determination of anterior posterior axis embryo GO:0008358 4 0.037
actin polymerization or depolymerization GO:0008154 2 0.037
Rat
sexual reproduction GO:0019953 36 0.037
g2 m transition of mitotic cell cycle GO:0000086 4 0.037
regulation of rna metabolic process GO:0051252 224 0.036
negative regulation of cell death GO:0060548 60 0.036
determination of left right symmetry GO:0007368 179 0.036
catabolic process GO:0009056 32 0.036
protein o linked glycosylation GO:0006493 4 0.036
neuron projection regeneration GO:0031102 16 0.035
proteasomal protein catabolic process GO:0010498 2 0.035
determination of bilateral symmetry GO:0009855 204 0.035
negative regulation of ras protein signal transduction GO:0046580 1 0.035
modification dependent macromolecule catabolic process GO:0043632 3 0.035
digestive system development GO:0055123 289 0.035
macromolecular complex assembly GO:0065003 35 0.035
Rat
immune system process GO:0002376 241 0.035
actin filament based movement GO:0030048 1 0.034
regulation of chromosome segregation GO:0051983 1 0.034
cellular carbohydrate metabolic process GO:0044262 4 0.034
response to wounding GO:0009611 116 0.034
negative regulation of multicellular organismal process GO:0051241 69 0.034
negative regulation of signaling GO:0023057 96 0.034
regulation of neurogenesis GO:0050767 87 0.034
nucleoside monophosphate catabolic process GO:0009125 4 0.033
tube morphogenesis GO:0035239 349 0.033
regulation of macromolecule biosynthetic process GO:0010556 225 0.033
regulation of gtp catabolic process GO:0033124 2 0.033
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.033
carboxylic acid metabolic process GO:0019752 22 0.033
regulation of primary metabolic process GO:0080090 311 0.032
localization of cell GO:0051674 244 0.032
regulation of carbohydrate metabolic process GO:0006109 4 0.032
mitotic cytokinesis GO:0000281 3 0.032
cellular aromatic compound metabolic process GO:0006725 295 0.032
melanosome localization GO:0032400 21 0.032
positive regulation of cellular process GO:0048522 201 0.032
centrosome organization GO:0051297 1 0.031
meiotic cell cycle process GO:1903046 3 0.031
single organism organelle organization GO:1902589 199 0.031
Rat
photoreceptor cell outer segment organization GO:0035845 9 0.031
positive regulation of cellular catabolic process GO:0031331 3 0.031
cell proliferation GO:0008283 80 0.031
behavior GO:0007610 74 0.030
translational initiation GO:0006413 3 0.030
regulation of cellular ketone metabolic process GO:0010565 7 0.030
establishment of localization in cell GO:0051649 77 0.030
cellular amine metabolic process GO:0044106 2 0.030
pole plasm assembly GO:0007315 4 0.029
regulation of multicellular organism growth GO:0040014 4 0.029
negative regulation of catabolic process GO:0009895 3 0.029
heterocycle biosynthetic process GO:0018130 215 0.029
transport GO:0006810 220 0.028
negative regulation of cellular biosynthetic process GO:0031327 55 0.028
chemotaxis GO:0006935 104 0.028
nucleic acid metabolic process GO:0090304 244 0.028
stem cell maintenance GO:0019827 4 0.028
regulation of protein complex assembly GO:0043254 3 0.028
Rat
regulation of nucleoside metabolic process GO:0009118 2 0.028
muscle cell differentiation GO:0042692 139 0.028
digestive tract morphogenesis GO:0048546 231 0.028
organic substance catabolic process GO:1901575 28 0.027
cellular component assembly involved in morphogenesis GO:0010927 107 0.027
neurological system process GO:0050877 62 0.027
regulation of nucleic acid templated transcription GO:1903506 213 0.027
positive regulation of cytoskeleton organization GO:0051495 3 0.027
nucleus localization GO:0051647 8 0.026
synaptic growth at neuromuscular junction GO:0051124 2 0.026
regulation of neuron differentiation GO:0045664 56 0.026
adult behavior GO:0030534 2 0.026
nucleic acid templated transcription GO:0097659 181 0.026
regulation of signal transduction GO:0009966 225 0.025
organonitrogen compound metabolic process GO:1901564 74 0.025
carbohydrate derivative metabolic process GO:1901135 61 0.025
cell substrate adhesion GO:0031589 4 0.025
regulation of signaling GO:0023051 235 0.025
regulation of reproductive process GO:2000241 4 0.025
macromolecule catabolic process GO:0009057 15 0.025
actin cytoskeleton organization GO:0030036 63 0.025
Rat
regulation of nervous system development GO:0051960 90 0.025
axis specification GO:0009798 43 0.024
macromolecule glycosylation GO:0043413 9 0.024
apoptotic process involved in development GO:1902742 2 0.024
response to chemical GO:0042221 320 0.024
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.024
negative regulation of intracellular transport GO:0032387 3 0.024
muscle cell development GO:0055001 115 0.024
regulation of multicellular organismal development GO:2000026 223 0.024
regulation of intracellular protein transport GO:0033157 3 0.024
cell motility GO:0048870 244 0.024
regulation of neuron projection development GO:0010975 40 0.023
cellular ketone metabolic process GO:0042180 11 0.023
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.023
organelle organization GO:0006996 227 0.023
Rat
carbohydrate homeostasis GO:0033500 1 0.023
purine nucleoside monophosphate catabolic process GO:0009128 4 0.023
cellular macromolecular complex assembly GO:0034622 24 0.023
Rat
negative regulation of protein transport GO:0051224 3 0.023
positive regulation of translation GO:0045727 1 0.023
single organism metabolic process GO:0044710 217 0.023
atp catabolic process GO:0006200 4 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.022
protein modification process GO:0036211 100 0.022
positive regulation of macromolecule metabolic process GO:0010604 93 0.022
macromolecular complex disassembly GO:0032984 1 0.022
system process GO:0003008 185 0.022
embryonic pattern specification GO:0009880 44 0.022
organic cyclic compound biosynthetic process GO:1901362 223 0.022
cellular response to external stimulus GO:0071496 2 0.022
regulation of cellular protein catabolic process GO:1903362 1 0.022
cytoplasm organization GO:0007028 4 0.022
mitotic cell cycle GO:0000278 64 0.021
positive regulation of histone modification GO:0031058 1 0.021
single organism cellular localization GO:1902580 46 0.021
germ line stem cell division GO:0042078 1 0.021
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.021
protein complex disassembly GO:0043241 1 0.021
cytokinetic process GO:0032506 2 0.021
negative regulation of axon regeneration GO:0048681 4 0.021
regulation of canonical wnt signaling pathway GO:0060828 34 0.021
multi organism reproductive process GO:0044703 36 0.021
aromatic compound biosynthetic process GO:0019438 217 0.021
cell cycle GO:0007049 93 0.021
double strand break repair GO:0006302 3 0.020
regeneration GO:0031099 91 0.020
morphogenesis of an epithelium GO:0002009 333 0.020
negative regulation of macromolecule metabolic process GO:0010605 76 0.020
cellular component disassembly GO:0022411 1 0.020
cell cycle process GO:0022402 53 0.020
wnt signaling pathway GO:0016055 80 0.020
positive regulation of dna metabolic process GO:0051054 1 0.020
oocyte anterior posterior axis specification GO:0007314 4 0.020
vasculature development GO:0001944 278 0.020
centrosome cycle GO:0007098 1 0.019
mitotic dna integrity checkpoint GO:0044774 4 0.019
macromolecular complex subunit organization GO:0043933 74 0.019
Rat
actin filament based process GO:0030029 64 0.019
Rat
positive regulation of protein complex assembly GO:0031334 2 0.019
purine nucleotide metabolic process GO:0006163 27 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
cell morphogenesis involved in differentiation GO:0000904 195 0.019
mitotic dna damage checkpoint GO:0044773 4 0.018
actomyosin structure organization GO:0031032 53 0.018
organelle assembly GO:0070925 110 0.018
negative regulation of developmental process GO:0051093 65 0.018
organic acid metabolic process GO:0006082 31 0.018
skin development GO:0043588 54 0.018
skeletal muscle organ development GO:0060538 78 0.018
cellular response to oxygen levels GO:0071453 1 0.018
regulation of cell projection organization GO:0031344 44 0.017
actin filament polymerization GO:0030041 2 0.017
Rat
positive regulation of cell cycle GO:0045787 3 0.017
modification dependent protein catabolic process GO:0019941 3 0.017
spermatid differentiation GO:0048515 2 0.017
protein complex biogenesis GO:0070271 30 0.017
Rat
purine containing compound metabolic process GO:0072521 29 0.017
myofibril assembly GO:0030239 48 0.017
plasma membrane repair GO:0001778 2 0.017
microtubule organizing center organization GO:0031023 1 0.017
regulation of locomotion GO:0040012 55 0.017
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.017
spermatid development GO:0007286 2 0.017
single organism transport GO:0044765 206 0.016
myosin filament organization GO:0031033 6 0.016
striated muscle cell development GO:0055002 108 0.016
regulation of developmental growth GO:0048638 38 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
meiotic nuclear division GO:0007126 4 0.016
negative regulation of signal transduction GO:0009968 94 0.016
synaptic vesicle localization GO:0097479 1 0.016
amine metabolic process GO:0009308 2 0.016
regulation of cell death GO:0010941 103 0.016
protein k63 linked ubiquitination GO:0070534 2 0.016
mitotic cell cycle process GO:1903047 48 0.016
vesicle mediated transport GO:0016192 22 0.015
regulation of gtpase activity GO:0043087 2 0.015
oxoacid metabolic process GO:0043436 31 0.015
establishment of protein localization to plasma membrane GO:0090002 1 0.015
regulation of protein metabolic process GO:0051246 56 0.015
anterior posterior pattern specification GO:0009952 152 0.015
cranial nerve development GO:0021545 42 0.015
regulation of nucleotide catabolic process GO:0030811 2 0.015
organism emergence from protective structure GO:0071684 4 0.015
regulation of calcium ion dependent exocytosis GO:0017158 1 0.015
regulation of protein targeting GO:1903533 2 0.015
protein complex localization GO:0031503 1 0.015
negative regulation of chromosome organization GO:2001251 1 0.014
cell matrix adhesion GO:0007160 4 0.014
dorsal ventral pattern formation GO:0009953 125 0.014
single organism biosynthetic process GO:0044711 71 0.014
stem cell differentiation GO:0048863 117 0.014
stem cell proliferation GO:0072089 4 0.014
glial cell migration GO:0008347 3 0.014
regulation of carbohydrate biosynthetic process GO:0043255 1 0.014
protein polyubiquitination GO:0000209 4 0.014
protein localization to nucleus GO:0034504 3 0.014
organelle fusion GO:0048284 3 0.014
positive regulation of protein polymerization GO:0032273 2 0.014
regulation of circadian rhythm GO:0042752 4 0.014
actin filament organization GO:0007015 15 0.014
Rat
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.014
cellular pigmentation GO:0033059 30 0.014
regulation of apoptotic process GO:0042981 98 0.014
posttranscriptional regulation of gene expression GO:0010608 14 0.013
regulation of cellular component movement GO:0051270 55 0.013
synaptic vesicle transport GO:0048489 1 0.013
cytoskeleton organization GO:0007010 96 0.013
Rat
protein polymerization GO:0051258 4 0.013
Rat
epithelial cell differentiation GO:0030855 116 0.013
macromolecule modification GO:0043412 111 0.013
regulation of oocyte development GO:0060281 3 0.013
neuron projection morphogenesis GO:0048812 161 0.013
ras protein signal transduction GO:0007265 7 0.013
neuromuscular process controlling balance GO:0050885 3 0.013
macromolecule localization GO:0033036 54 0.013
telomere maintenance GO:0000723 1 0.013
epithelial cell development GO:0002064 42 0.013
negative regulation of cell communication GO:0010648 96 0.013
purine ribonucleotide metabolic process GO:0009150 27 0.013
convergent extension GO:0060026 118 0.013
negative regulation of neuron projection regeneration GO:0070571 4 0.013
reproduction GO:0000003 40 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
hatching GO:0035188 4 0.013
regulation of purine nucleotide catabolic process GO:0033121 2 0.013
blood vessel morphogenesis GO:0048514 216 0.013
protein import GO:0017038 3 0.013
regulation of cell activation GO:0050865 1 0.012
positive regulation of chromosome organization GO:2001252 1 0.012
response to external biotic stimulus GO:0043207 97 0.012
response to other organism GO:0051707 97 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
microtubule cytoskeleton organization GO:0000226 33 0.012
neuroblast proliferation GO:0007405 2 0.012
regulation of purine nucleotide metabolic process GO:1900542 17 0.012
heart development GO:0007507 313 0.012
sensory perception of pain GO:0019233 1 0.012
regulation of programmed cell death GO:0043067 101 0.012
protein complex assembly GO:0006461 30 0.012
Rat
regulation of cellular component organization GO:0051128 86 0.012
Rat
calcium ion dependent exocytosis GO:0017156 1 0.012
apoptotic process involved in morphogenesis GO:0060561 2 0.012
signal transduction in absence of ligand GO:0038034 1 0.012
regulation of wnt signaling pathway GO:0030111 53 0.012
single organism membrane fusion GO:0044801 2 0.012
hematopoietic or lymphoid organ development GO:0048534 191 0.012
multicellular organism reproduction GO:0032504 35 0.012
regulation of stem cell differentiation GO:2000736 4 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
membrane fusion GO:0061025 2 0.012
negative regulation of nervous system development GO:0051961 22 0.011
embryonic organ development GO:0048568 381 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.011
response to stress GO:0006950 263 0.011
cellular macromolecule localization GO:0070727 21 0.011
developmental programmed cell death GO:0010623 4 0.011
homeostatic process GO:0042592 142 0.011
left right pattern formation GO:0060972 19 0.011
mechanosensory behavior GO:0007638 2 0.011
germ line stem cell maintenance GO:0030718 2 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
regulation of cell cycle GO:0051726 52 0.011
establishment of endothelial barrier GO:0061028 3 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
nucleobase containing small molecule metabolic process GO:0055086 32 0.011
action potential GO:0001508 19 0.011
digestive tract development GO:0048565 265 0.011
golgi vesicle transport GO:0048193 3 0.011
positive regulation of wound healing GO:0090303 1 0.011
antimicrobial humoral response GO:0019730 2 0.011
ribonucleotide metabolic process GO:0009259 27 0.011
rna localization GO:0006403 4 0.011
regulation of response to stimulus GO:0048583 269 0.011
polarized epithelial cell differentiation GO:0030859 4 0.011
regulation of synapse organization GO:0050807 3 0.011
negative regulation of cellular metabolic process GO:0031324 77 0.010
chemosensory behavior GO:0007635 1 0.010
mesoderm development GO:0007498 88 0.010
canonical wnt signaling pathway GO:0060070 48 0.010
response to nutrient GO:0007584 3 0.010
adherens junction organization GO:0034332 4 0.010
negative regulation of protein processing GO:0010955 10 0.010
macromolecule deacylation GO:0098732 3 0.010
positive regulation of cell adhesion GO:0045785 1 0.010
regulation of anatomical structure size GO:0090066 33 0.010
Rat
positive regulation of apoptotic signaling pathway GO:2001235 1 0.010
forebrain cell migration GO:0021885 1 0.010
mitotic g2 dna damage checkpoint GO:0007095 3 0.010
endocytosis GO:0006897 16 0.010
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
heterocycle catabolic process GO:0046700 15 0.010

pfn2l disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.050
nervous system disease DOID:863 0 0.019
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
organ system cancer DOID:0050686 0 0.019
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.010
eye disease DOID:5614 0 0.010