Danio rerio

87 known processes

pitx2

paired-like homeodomain transcription factor 2

(Aliases: pitx2a,pitx2c,zgc:110508,MGC110508)

pitx2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
heterocycle metabolic process GO:0046483 290 0.994
Human Zebrafish Mouse Rat Worm
regionalization GO:0003002 274 0.987
erythrocyte differentiation GO:0030218 54 0.984
central nervous system development GO:0007417 387 0.982
Zebrafish Mouse Rat
myeloid cell homeostasis GO:0002262 56 0.978
digestive system development GO:0055123 289 0.975
erythrocyte homeostasis GO:0034101 55 0.965
nucleobase containing compound metabolic process GO:0006139 274 0.965
Human Zebrafish Mouse Rat Worm
generation of neurons GO:0048699 385 0.964
Mouse Rat Worm Fly
embryonic organ development GO:0048568 381 0.959
transcription dna templated GO:0006351 181 0.955
Human Zebrafish Mouse Rat Worm
cellular aromatic compound metabolic process GO:0006725 295 0.954
Human Zebrafish Mouse Rat Worm
specification of symmetry GO:0009799 204 0.948
nucleic acid metabolic process GO:0090304 244 0.942
Human Zebrafish Mouse Rat Worm
regulation of biological quality GO:0065008 263 0.941
morphogenesis of an epithelial sheet GO:0002011 49 0.937
regulation of cellular metabolic process GO:0031323 320 0.932
Human Zebrafish Mouse Rat Worm
aromatic compound biosynthetic process GO:0019438 217 0.928
Human Zebrafish Mouse Rat Worm
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.927
Human Mouse Rat Worm
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.916
Human Zebrafish Mouse Rat Worm
regulation of nucleic acid templated transcription GO:1903506 213 0.916
Human Zebrafish Mouse Rat Worm
skeletal system development GO:0001501 181 0.909
organic cyclic compound metabolic process GO:1901360 301 0.907
Human Zebrafish Mouse Rat Worm
embryonic skeletal system morphogenesis GO:0048704 93 0.899
cellular macromolecule biosynthetic process GO:0034645 224 0.884
Human Zebrafish Mouse Rat Worm
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.880
Human
positive regulation of metabolic process GO:0009893 108 0.878
Human Zebrafish Mouse Rat Worm
regulation of gene expression GO:0010468 265 0.875
Human Zebrafish Mouse Rat Worm
organic cyclic compound biosynthetic process GO:1901362 223 0.841
Human Zebrafish Mouse Rat Worm
chordate embryonic development GO:0043009 271 0.840
positive regulation of macromolecule metabolic process GO:0010604 93 0.832
Human Zebrafish Mouse Rat Worm
negative regulation of cellular process GO:0048523 283 0.832
Human
embryonic skeletal system development GO:0048706 97 0.829
positive regulation of rna metabolic process GO:0051254 59 0.826
Human Zebrafish Mouse Rat Worm
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.823
Human Zebrafish Mouse Rat Worm
regulation of biosynthetic process GO:0009889 250 0.822
Human Zebrafish Mouse Rat Worm
cell differentiation in spinal cord GO:0021515 40 0.811
regulation of multicellular organismal process GO:0051239 277 0.797
hemopoiesis GO:0030097 183 0.795
regulation of cellular biosynthetic process GO:0031326 245 0.786
Human Zebrafish Mouse Rat Worm
regulation of rna biosynthetic process GO:2001141 213 0.786
Human Zebrafish Mouse Rat Worm
heterocycle biosynthetic process GO:0018130 215 0.785
Human Zebrafish Mouse Rat Worm
regulation of nitrogen compound metabolic process GO:0051171 251 0.780
Human Zebrafish Mouse Rat Worm
regulation of transcription dna templated GO:0006355 213 0.777
Human Zebrafish Mouse Rat Worm
homeostasis of number of cells GO:0048872 62 0.775
positive regulation of cellular metabolic process GO:0031325 94 0.769
Human Zebrafish Mouse Rat Worm
muscle structure development GO:0061061 196 0.751
Mouse
pituitary gland development GO:0021983 16 0.747
Zebrafish Mouse
otic placode formation GO:0043049 23 0.746
determination of heart left right asymmetry GO:0061371 117 0.745
positive regulation of nucleic acid templated transcription GO:1903508 57 0.738
Human Zebrafish Mouse Rat Worm
diencephalon development GO:0021536 58 0.734
Zebrafish Mouse
gland development GO:0048732 143 0.733
Zebrafish Mouse
digestive tract morphogenesis GO:0048546 231 0.730
Mouse
rna metabolic process GO:0016070 219 0.727
Human Zebrafish Mouse Rat Worm
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.724
Human Zebrafish Mouse Rat Worm
neuron projection guidance GO:0097485 86 0.709
Worm
immune system process GO:0002376 241 0.705
Mouse
positive regulation of neuron migration GO:2001224 2 0.704
cell proliferation GO:0008283 80 0.700
Mouse
ectodermal placode development GO:0071696 37 0.698
positive regulation of gene expression GO:0010628 71 0.694
Human Zebrafish Mouse Rat Worm
embryonic viscerocranium morphogenesis GO:0048703 52 0.683
digestive tract development GO:0048565 265 0.678
transcription from rna polymerase ii promoter GO:0006366 80 0.673
Human Mouse Rat Worm
regulation of metabolic process GO:0019222 359 0.673
Human Zebrafish Mouse Rat Worm
regulation of rna metabolic process GO:0051252 224 0.667
Human Zebrafish Mouse Rat Worm
eye morphogenesis GO:0048592 144 0.665
regulation of macromolecule biosynthetic process GO:0010556 225 0.658
Human Zebrafish Mouse Rat Worm
nitrogen compound metabolic process GO:0006807 319 0.658
Human Zebrafish Mouse Rat Worm
neuron fate commitment GO:0048663 26 0.654
behavior GO:0007610 74 0.648
regulation of primary metabolic process GO:0080090 311 0.647
Human Zebrafish Mouse Rat Worm
spinal cord development GO:0021510 46 0.626
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.621
Human Zebrafish Mouse Rat Worm
sensory organ morphogenesis GO:0090596 200 0.620
gene expression GO:0010467 252 0.616
Human Zebrafish Mouse Rat Worm
cell fate specification GO:0001708 68 0.599
cellular component movement GO:0006928 335 0.597
Mouse Worm
head development GO:0060322 303 0.597
nucleic acid templated transcription GO:0097659 181 0.596
Human Zebrafish Mouse Rat Worm
cell projection morphogenesis GO:0048858 244 0.592
Worm Fly
cell fate commitment GO:0045165 99 0.590
regulation of vascular permeability GO:0043114 5 0.580
muscle cell differentiation GO:0042692 139 0.573
Mouse
inner ear morphogenesis GO:0042472 63 0.572
brain development GO:0007420 293 0.561
Zebrafish Mouse Rat
cellular nitrogen compound biosynthetic process GO:0044271 218 0.557
Human Zebrafish Mouse Rat Worm
cell migration GO:0016477 237 0.553
Mouse
organic substance biosynthetic process GO:1901576 289 0.549
Human Zebrafish Mouse Rat Worm
mesenchyme development GO:0060485 127 0.540
Mouse
stem cell proliferation GO:0072089 4 0.522
otic vesicle morphogenesis GO:0071600 34 0.510
positive regulation of cellular biosynthetic process GO:0031328 68 0.503
Human Zebrafish Mouse Rat Worm
negative regulation of transcription dna templated GO:0045892 45 0.499
Human
determination of bilateral symmetry GO:0009855 204 0.489
otic vesicle formation GO:0030916 27 0.478
negative regulation of nucleic acid templated transcription GO:1903507 45 0.477
Human
cell migration to the midline involved in heart development GO:0003318 12 0.475
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.473
circulatory system process GO:0003013 87 0.469
heart process GO:0003015 71 0.468
neural crest cell differentiation GO:0014033 72 0.464
Mouse
embryonic organ morphogenesis GO:0048562 274 0.462
epidermal cell differentiation GO:0009913 36 0.457
nucleobase containing compound biosynthetic process GO:0034654 205 0.456
Human Zebrafish Mouse Rat Worm
striated muscle tissue development GO:0014706 110 0.444
Mouse
central nervous system myelin formation GO:0032289 1 0.437
embryonic cranial skeleton morphogenesis GO:0048701 90 0.435
anterior posterior pattern specification GO:0009952 152 0.432
ectodermal placode morphogenesis GO:0071697 32 0.430
sensory organ development GO:0007423 393 0.430
gastrulation with mouth forming second GO:0001702 44 0.427
positive regulation of biosynthetic process GO:0009891 68 0.426
Human Zebrafish Mouse Rat Worm
mesoderm development GO:0007498 88 0.420
gastrulation GO:0007369 208 0.419
left right pattern formation GO:0060972 19 0.416
primitive hemopoiesis GO:0060215 27 0.414
tube morphogenesis GO:0035239 349 0.409
Mouse
mesoderm morphogenesis GO:0048332 51 0.405
aging GO:0007568 2 0.399
oligodendrocyte differentiation GO:0048709 23 0.398
embryonic camera type eye formation GO:0060900 10 0.396
macromolecule biosynthetic process GO:0009059 227 0.393
Human Zebrafish Mouse Rat Worm
heart field specification GO:0003128 1 0.391
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.390
Human
appendage development GO:0048736 80 0.389
Human Mouse
thyroid gland development GO:0030878 12 0.380
positive regulation of cellular process GO:0048522 201 0.378
Human Zebrafish Mouse Rat Worm
cell motility GO:0048870 244 0.377
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.376
Human Zebrafish Mouse Rat Worm
negative regulation of muscle tissue development GO:1901862 2 0.376
foregut morphogenesis GO:0007440 4 0.375
wnt signaling pathway GO:0016055 80 0.375
Mouse
cranial nerve development GO:0021545 42 0.374
heart development GO:0007507 313 0.373
regulation of developmental process GO:0050793 247 0.373
negative regulation of biological process GO:0048519 304 0.371
Human
positive regulation of biological process GO:0048518 253 0.368
Human Zebrafish Mouse Rat Worm
cardioblast migration GO:0003260 7 0.366
endoderm development GO:0007492 49 0.366
cell morphogenesis GO:0000902 289 0.364
Worm Fly
embryonic hemopoiesis GO:0035162 53 0.361
negative regulation of gene expression GO:0010629 65 0.352
Human
regulation of cell differentiation GO:0045595 142 0.350
positive regulation of transcription dna templated GO:0045893 57 0.348
Human Zebrafish Mouse Rat Worm
endocrine system development GO:0035270 65 0.343
Zebrafish Mouse
homeostatic process GO:0042592 142 0.338
taxis GO:0042330 109 0.336
Worm
blood circulation GO:0008015 87 0.327
optic cup morphogenesis involved in camera type eye development GO:0002072 7 0.326
heart formation GO:0060914 13 0.325
striated muscle cell differentiation GO:0051146 129 0.324
Mouse
mesenchymal cell development GO:0014031 78 0.312
Mouse
localization of cell GO:0051674 244 0.311
Mouse
camera type eye development GO:0043010 222 0.310
axon guidance GO:0007411 86 0.308
Worm
ectodermal placode formation GO:0060788 26 0.303
rna biosynthetic process GO:0032774 181 0.300
Human Zebrafish Mouse Rat Worm
cellular biosynthetic process GO:0044249 286 0.296
Human Zebrafish Mouse Rat Worm
regulation of erythrocyte differentiation GO:0045646 2 0.289
negative regulation of cellular metabolic process GO:0031324 77 0.285
Human
atrioventricular valve formation GO:0003190 3 0.284
connective tissue development GO:0061448 99 0.280
neuroepithelial cell differentiation GO:0060563 26 0.277
ear morphogenesis GO:0042471 64 0.275
regulation of neuron migration GO:2001222 2 0.274
oligodendrocyte cell fate specification GO:0021778 4 0.273
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.273
Human Mouse Rat Worm
cardiac muscle cell differentiation GO:0055007 30 0.272
Mouse
axonogenesis GO:0007409 152 0.270
Worm
embryonic heart tube development GO:0035050 133 0.269
positive regulation of nervous system development GO:0051962 25 0.252
heart valve formation GO:0003188 4 0.248
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.239
Human Zebrafish Mouse Rat Worm
larval development GO:0002164 2 0.235
forebrain neuron fate commitment GO:0021877 1 0.234
system process GO:0003008 185 0.233
regulation of macromolecule metabolic process GO:0060255 317 0.232
Human Zebrafish Mouse Rat Worm
ventral spinal cord development GO:0021517 35 0.226
ear development GO:0043583 127 0.226
semicircular canal development GO:0060872 24 0.225
tissue regeneration GO:0042246 74 0.223
cardiac muscle tissue development GO:0048738 48 0.223
Mouse
regulation of heart morphogenesis GO:2000826 17 0.221
female sex differentiation GO:0046660 4 0.221
Rat
regulation of heart contraction GO:0008016 32 0.220
hematopoietic or lymphoid organ development GO:0048534 191 0.219
Mouse
negative regulation of cellular biosynthetic process GO:0031327 55 0.219
Human
negative regulation of biosynthetic process GO:0009890 55 0.218
Human
nerve development GO:0021675 45 0.218
cell migration involved in gastrulation GO:0042074 79 0.216
cartilage development GO:0051216 96 0.215
heart jogging GO:0003146 40 0.211
epidermal cell fate specification GO:0009957 4 0.210
positive regulation of rna biosynthetic process GO:1902680 57 0.210
Human Zebrafish Mouse Rat Worm
embryo development ending in birth or egg hatching GO:0009792 271 0.206
cell growth GO:0016049 57 0.201
heart contraction GO:0060047 71 0.201
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.200
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.199
otic vesicle development GO:0071599 42 0.197
formation of primary germ layer GO:0001704 62 0.195
locomotion GO:0040011 313 0.194
Mouse Worm
neural plate pattern specification GO:0060896 12 0.192
muscle tissue development GO:0060537 110 0.191
Mouse
endodermal cell fate determination GO:0007493 2 0.189
regulation of multicellular organismal development GO:2000026 223 0.184
adenohypophysis development GO:0021984 15 0.183
Zebrafish
epithelial cell differentiation GO:0030855 116 0.182
endodermal cell differentiation GO:0035987 19 0.181
cardiac chamber formation GO:0003207 4 0.177
negative regulation of macromolecule metabolic process GO:0010605 76 0.169
Human
mechanoreceptor differentiation GO:0042490 37 0.168
protein targeting to nucleus GO:0044744 3 0.168
axon development GO:0061564 166 0.168
Worm
central nervous system myelination GO:0022010 2 0.165
cell surface receptor signaling pathway GO:0007166 325 0.165
Mouse
forebrain development GO:0030900 96 0.164
Zebrafish Mouse
auditory receptor cell fate commitment GO:0009912 4 0.164
enteric nervous system development GO:0048484 12 0.162
regulation of epithelial cell proliferation GO:0050678 3 0.161
epidermis development GO:0008544 48 0.159
cellular component morphogenesis GO:0032989 336 0.159
Worm Fly
response to external stimulus GO:0009605 264 0.158
Rat Worm
lens development in camera type eye GO:0002088 22 0.158
Zebrafish
apoptotic process GO:0006915 116 0.158
negative regulation of rna biosynthetic process GO:1902679 45 0.152
Human
skeletal system morphogenesis GO:0048705 102 0.148
neural tube development GO:0021915 62 0.147
cellular nitrogen compound metabolic process GO:0034641 290 0.146
Human Zebrafish Mouse Rat Worm
neuron differentiation GO:0030182 353 0.145
Rat Worm Fly
determination of left right symmetry GO:0007368 179 0.145
response to chemical GO:0042221 320 0.144
Rat Worm
hindbrain development GO:0030902 91 0.143
cell death GO:0008219 121 0.138
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.137
wound healing GO:0042060 90 0.137
retina development in camera type eye GO:0060041 146 0.137
floor plate development GO:0033504 15 0.136
positive regulation of axon guidance GO:1902669 1 0.134
hair cell differentiation GO:0035315 32 0.134
response to organic substance GO:0010033 153 0.132
Rat
glial cell migration GO:0008347 3 0.132
positive regulation of muscle cell differentiation GO:0051149 1 0.130
pancreatic a cell development GO:0003322 2 0.128
nucleocytoplasmic transport GO:0006913 4 0.127
nuclear transport GO:0051169 4 0.127
pectoral fin development GO:0033339 50 0.126
gamete generation GO:0007276 33 0.125
ventral spinal cord interneuron differentiation GO:0021514 12 0.124
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.124
regulation of apoptotic process GO:0042981 98 0.124
myotube differentiation GO:0014902 45 0.123
Mouse
cranial ganglion development GO:0061550 3 0.122
regulation of endodermal cell fate specification GO:0042663 15 0.121
regulation of programmed cell death GO:0043067 101 0.118
neuroblast proliferation GO:0007405 2 0.118
astrocyte differentiation GO:0048708 1 0.118
endodermal cell fate specification GO:0001714 17 0.117
pancreas development GO:0031016 84 0.116
dorsal ventral pattern formation GO:0009953 125 0.116
signal transduction GO:0007165 455 0.116
cellular component assembly GO:0022607 170 0.116
sympathetic nervous system development GO:0048485 3 0.115
cellular component assembly involved in morphogenesis GO:0010927 107 0.114
camera type eye morphogenesis GO:0048593 108 0.113
post embryonic morphogenesis GO:0009886 4 0.112
cell morphogenesis involved in differentiation GO:0000904 195 0.108
Worm Fly
regulation of dna metabolic process GO:0051052 11 0.104
epiboly GO:0090504 41 0.104
lymphocyte proliferation GO:0046651 1 0.104
cellular response to chemical stimulus GO:0070887 157 0.103
regulation of cellular component organization GO:0051128 86 0.103
morphogenesis of an epithelium GO:0002009 333 0.102
bmp signaling pathway GO:0030509 52 0.102
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.101
Human
ossification GO:0001503 23 0.101
mesenchymal cell differentiation GO:0048762 87 0.100
Mouse
regulation of gastrulation GO:0010470 24 0.098
retina morphogenesis in camera type eye GO:0060042 79 0.097
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.097
central nervous system neuron differentiation GO:0021953 74 0.095
regulation of cell proliferation GO:0042127 37 0.095
Mouse
exocrine pancreas development GO:0031017 28 0.094
inner ear receptor cell fate commitment GO:0060120 4 0.094
embryonic neurocranium morphogenesis GO:0048702 15 0.094
embryonic heart tube morphogenesis GO:0003143 108 0.093
negative regulation of metabolic process GO:0009892 86 0.093
Human
hatching gland development GO:0048785 3 0.092
myeloid cell differentiation GO:0030099 86 0.091
type b pancreatic cell development GO:0003323 4 0.091
mesoderm formation GO:0001707 43 0.091
pigmentation GO:0043473 85 0.089
development of primary female sexual characteristics GO:0046545 4 0.089
Rat
aorta development GO:0035904 4 0.089
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.088
neural crest cell migration GO:0001755 42 0.086
Mouse
negative regulation of response to stimulus GO:0048585 104 0.085
closure of optic fissure GO:0061386 6 0.084
head morphogenesis GO:0060323 8 0.084
germ line stem cell maintenance GO:0030718 2 0.082
response to growth factor GO:0070848 39 0.082
endodermal cell fate commitment GO:0001711 18 0.082
mononuclear cell proliferation GO:0032943 1 0.080
embryonic digestive tract morphogenesis GO:0048557 3 0.079
Mouse
glial cell fate commitment GO:0021781 6 0.079
glial cell fate specification GO:0021780 4 0.079
inner ear development GO:0048839 126 0.078
cell projection organization GO:0030030 284 0.077
Worm Fly
biosynthetic process GO:0009058 294 0.076
Human Zebrafish Mouse Rat Worm
eye development GO:0001654 277 0.076
convergent extension involved in organogenesis GO:0060029 10 0.076
regulation of molecular function GO:0065009 70 0.076
Mouse
pectoral fin morphogenesis GO:0035138 29 0.076
positive regulation of epithelial cell differentiation GO:0030858 2 0.075
axon ensheathment in central nervous system GO:0032291 2 0.075
regulation of binding GO:0051098 3 0.074
Mouse
stem cell division GO:0017145 1 0.074
positive regulation of striated muscle cell differentiation GO:0051155 1 0.073
heart looping GO:0001947 94 0.073
sprouting angiogenesis GO:0002040 53 0.073
positive regulation of cellular component movement GO:0051272 11 0.072
ovarian follicle development GO:0001541 2 0.070
neural plate regionalization GO:0060897 10 0.069
regulation of organ growth GO:0046620 3 0.068
regulation of mesenchymal cell proliferation GO:0010464 1 0.067
response to lipid GO:0033993 60 0.067
Rat
liver development GO:0001889 96 0.066
glial cell differentiation GO:0010001 42 0.066
positive regulation of epithelial cell proliferation GO:0050679 1 0.065
dorsal aorta morphogenesis GO:0035912 3 0.065
water homeostasis GO:0030104 4 0.064
male gamete generation GO:0048232 7 0.063
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.062
regulation of neurogenesis GO:0050767 87 0.062
pharyngeal muscle development GO:0043282 4 0.061
photoreceptor cell differentiation GO:0046530 55 0.061
atrial cardiac muscle cell differentiation GO:0055011 5 0.060
developmental pigmentation GO:0048066 48 0.060
lens morphogenesis in camera type eye GO:0002089 7 0.059
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.058
positive regulation of cell migration GO:0030335 11 0.058
neuron fate specification GO:0048665 20 0.057
positive regulation of stem cell proliferation GO:2000648 1 0.057
hepaticobiliary system development GO:0061008 98 0.056
myeloid cell development GO:0061515 32 0.056
ovulation cycle GO:0042698 2 0.055
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.054
mesenchymal cell proliferation GO:0010463 1 0.053
leukocyte proliferation GO:0070661 1 0.053
spinal cord motor neuron differentiation GO:0021522 26 0.053
skin development GO:0043588 54 0.052
axon extension GO:0048675 45 0.052
regulation of cell communication GO:0010646 232 0.052
regulation of cell death GO:0010941 103 0.052
negative regulation of mesodermal cell fate specification GO:0042662 3 0.052
neuronal action potential GO:0019228 18 0.052
enzyme linked receptor protein signaling pathway GO:0007167 106 0.051
endocrine pancreas development GO:0031018 27 0.051
positive regulation of cell motility GO:2000147 11 0.051
ventral midline development GO:0007418 13 0.050
artery development GO:0060840 22 0.050
telencephalon development GO:0021537 14 0.049
negative regulation of leukocyte differentiation GO:1902106 1 0.049
bmp signaling pathway involved in heart jogging GO:0003303 14 0.049
stem cell maintenance GO:0019827 4 0.049
regulation of locomotion GO:0040012 55 0.049
Mouse Worm
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.048
motor neuron axon guidance GO:0008045 23 0.048
dorsal ventral neural tube patterning GO:0021904 1 0.048
cardiac muscle tissue regeneration GO:0061026 3 0.048
macrophage differentiation GO:0030225 7 0.047
inner ear receptor cell differentiation GO:0060113 29 0.047
female gonad development GO:0008585 4 0.046
Rat
determination of left right asymmetry in nervous system GO:0035545 4 0.046
anterior posterior axis specification GO:0009948 20 0.046
endocardium formation GO:0060214 1 0.046
pigment cell differentiation GO:0050931 38 0.045
muscle cell development GO:0055001 115 0.044
Mouse
polarized epithelial cell differentiation GO:0030859 4 0.044
fin development GO:0033333 77 0.044
programmed cell death GO:0012501 119 0.043
positive regulation of cell differentiation GO:0045597 30 0.043
negative regulation of cell differentiation GO:0045596 46 0.043
positive regulation of gastrulation GO:2000543 2 0.043
negative regulation of myeloid cell differentiation GO:0045638 1 0.042
fin morphogenesis GO:0033334 53 0.042
regeneration GO:0031099 91 0.042
mesodermal cell fate specification GO:0007501 12 0.042
regulation of cardiac muscle tissue development GO:0055024 1 0.042
positive regulation of neurogenesis GO:0050769 24 0.041
pancreatic d cell differentiation GO:0003311 2 0.041
regulation of signaling GO:0023051 235 0.041
oligodendrocyte development GO:0014003 7 0.041
activin receptor signaling pathway GO:0032924 8 0.040
stem cell development GO:0048864 82 0.040
Mouse
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.040
regulation of organ morphogenesis GO:2000027 35 0.040
monocyte differentiation GO:0030224 2 0.040
lateral line ganglion development GO:0048890 2 0.040
midbrain hindbrain boundary development GO:0030917 23 0.040
intestinal epithelial cell differentiation GO:0060575 3 0.039
erythrocyte development GO:0048821 24 0.039
muscle organ morphogenesis GO:0048644 8 0.038
Mouse
hepatocyte differentiation GO:0070365 1 0.038
negative regulation of muscle organ development GO:0048635 5 0.038
multi organism process GO:0051704 134 0.037
forebrain regionalization GO:0021871 4 0.037
odontogenesis of dentin containing tooth GO:0042475 1 0.037
Rat
neuron fate determination GO:0048664 2 0.037
anterior commissure morphogenesis GO:0021960 3 0.036
adult behavior GO:0030534 2 0.036
ventricular cardiac muscle tissue development GO:0003229 3 0.036
canonical wnt signaling pathway GO:0060070 48 0.036
definitive hemopoiesis GO:0060216 18 0.036
cell migration involved in heart formation GO:0060974 10 0.035
medial fin morphogenesis GO:0035141 14 0.034
regulation of epidermis development GO:0045682 2 0.034
trigeminal nerve development GO:0021559 3 0.034
negative regulation of cell proliferation GO:0008285 8 0.034
striated muscle cell development GO:0055002 108 0.034
Mouse
stem cell differentiation GO:0048863 117 0.034
Mouse
ectoderm formation GO:0001705 2 0.034
fin regeneration GO:0031101 51 0.034
regulation of transcription involved in cell fate commitment GO:0060850 1 0.033
midbrain development GO:0030901 28 0.033
atrioventricular valve morphogenesis GO:0003181 6 0.033
endoderm formation GO:0001706 29 0.033
neural plate anterior posterior regionalization GO:0021999 8 0.033
forebrain generation of neurons GO:0021872 14 0.032
heart morphogenesis GO:0003007 156 0.032
Mouse
neural nucleus development GO:0048857 15 0.032
Mouse
organonitrogen compound metabolic process GO:1901564 74 0.032
response to glucocorticoid GO:0051384 1 0.032
immune system development GO:0002520 191 0.032
Mouse
nuclear import GO:0051170 3 0.031
post embryonic foregut morphogenesis GO:0048618 3 0.031
artery morphogenesis GO:0048844 14 0.030
multi organism reproductive process GO:0044703 36 0.030
striated muscle cell proliferation GO:0014855 7 0.030
stem cell fate determination GO:0048867 1 0.030
lateral line nerve glial cell differentiation GO:0048895 6 0.030
neuroblast differentiation GO:0014016 1 0.029
response to abiotic stimulus GO:0009628 122 0.029
cellular response to growth factor stimulus GO:0071363 39 0.029
optomotor response GO:0071632 1 0.029
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.029
Human
embryonic pectoral fin morphogenesis GO:0035118 24 0.029
endocardial cushion morphogenesis GO:0003203 3 0.029
somatic muscle development GO:0007525 4 0.028
epithelial tube morphogenesis GO:0060562 148 0.028
Mouse
myelin assembly GO:0032288 1 0.028
positive regulation of muscle tissue development GO:1901863 1 0.028
embryonic appendage morphogenesis GO:0035113 30 0.028
Mouse
pronephric glomerulus development GO:0039021 13 0.027
exocrine system development GO:0035272 28 0.027
protein localization to nucleus GO:0034504 3 0.027
ameboidal type cell migration GO:0001667 143 0.027
Mouse
nephron tubule epithelial cell differentiation GO:0072160 1 0.027
determination of digestive tract left right asymmetry GO:0071907 10 0.027
muscle cell fate commitment GO:0042693 9 0.027
apoptotic process involved in development GO:1902742 2 0.027
oligodendrocyte cell fate commitment GO:0021779 5 0.027
ganglion development GO:0061548 5 0.026
sex determination GO:0007530 1 0.026
regulation of glial cell differentiation GO:0045685 4 0.026
cell cycle g1 s phase transition GO:0044843 1 0.026
positive regulation of endothelial cell differentiation GO:0045603 2 0.026
mesendoderm development GO:0048382 10 0.026
response to wounding GO:0009611 116 0.026
death GO:0016265 121 0.026
appendage morphogenesis GO:0035107 56 0.026
Mouse
gabaergic neuron differentiation GO:0097154 2 0.026
Worm
primitive erythrocyte differentiation GO:0060319 5 0.026
cell proliferation in forebrain GO:0021846 3 0.026
cell differentiation in hindbrain GO:0021533 5 0.025
nephron epithelium morphogenesis GO:0072088 1 0.025
determination of pancreatic left right asymmetry GO:0035469 11 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.025
Human
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.025
negative regulation of programmed cell death GO:0043069 58 0.024
positive regulation of programmed cell death GO:0043068 29 0.024
positive regulation of leukocyte differentiation GO:1902107 1 0.024
positive regulation of cellular catabolic process GO:0031331 3 0.024
glomerulus morphogenesis GO:0072102 7 0.024
semicircular canal morphogenesis GO:0048752 18 0.024
organic hydroxy compound biosynthetic process GO:1901617 6 0.024
negative regulation of apoptotic process GO:0043066 55 0.024
monocarboxylic acid biosynthetic process GO:0072330 12 0.024

pitx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.050
bone disease DOID:0080001 0 0.050
disease of anatomical entity DOID:7 0 0.050
musculoskeletal system disease DOID:17 0 0.050
connective tissue disease DOID:65 0 0.050