Danio rerio

0 known processes

pkp1

plakophilin 1

(Aliases: fb30d08,wu:fb30d08)

pkp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
hemopoiesis GO:0030097 183 0.555
keratinocyte differentiation GO:0030216 0 0.408
intestinal absorption GO:0050892 2 0.286
heart development GO:0007507 313 0.272
Zebrafish
intestinal cholesterol absorption GO:0030299 2 0.199
hematopoietic or lymphoid organ development GO:0048534 191 0.172
wound healing GO:0042060 90 0.163
regulation of biological quality GO:0065008 263 0.161
desmosome organization GO:0002934 3 0.161
Zebrafish
tissue regeneration GO:0042246 74 0.161
fin regeneration GO:0031101 51 0.156
embryonic organ development GO:0048568 381 0.153
Zebrafish
single organism organelle organization GO:1902589 199 0.144
Worm
epidermal cell differentiation GO:0009913 36 0.144
phagocytosis GO:0006909 3 0.140
ion transport GO:0006811 114 0.130
chordate embryonic development GO:0043009 271 0.116
cellular macromolecule metabolic process GO:0044260 391 0.114
cell motility GO:0048870 244 0.112
regeneration GO:0031099 91 0.111
single organism membrane fusion GO:0044801 2 0.102
developmental growth GO:0048589 166 0.100
cellular component assembly GO:0022607 170 0.095
cellular component movement GO:0006928 335 0.091
myofibril assembly GO:0030239 48 0.090
system process GO:0003008 185 0.088
blood vessel morphogenesis GO:0048514 216 0.086
organelle fusion GO:0048284 3 0.083
immune system development GO:0002520 191 0.081
organelle organization GO:0006996 227 0.080
Worm
localization of cell GO:0051674 244 0.075
muscle cell development GO:0055001 115 0.073
immune system process GO:0002376 241 0.070
skin development GO:0043588 54 0.070
positive regulation of transport GO:0051050 2 0.067
membrane fusion GO:0061025 2 0.067
desmosome assembly GO:0002159 2 0.066
plasma membrane repair GO:0001778 2 0.066
embryonic organ morphogenesis GO:0048562 274 0.065
Zebrafish
morphogenesis of an epithelium GO:0002009 333 0.060
Zebrafish
phagocytosis engulfment GO:0006911 1 0.059
action potential GO:0001508 19 0.058
lipid digestion GO:0044241 3 0.056
response to stress GO:0006950 263 0.056
single fertilization GO:0007338 3 0.053
inner ear development GO:0048839 126 0.052
regulation of multicellular organismal process GO:0051239 277 0.051
membrane invagination GO:0010324 1 0.051
rna metabolic process GO:0016070 219 0.051
striated muscle cell differentiation GO:0051146 129 0.050
response to corticosteroid GO:0031960 1 0.050
ear development GO:0043583 127 0.050
regulation of establishment of protein localization GO:0070201 4 0.050
signal transduction GO:0007165 455 0.049
multi organism process GO:0051704 134 0.046
digestive system process GO:0022600 9 0.046
gastrulation GO:0007369 208 0.045
muscle cell differentiation GO:0042692 139 0.045
growth GO:0040007 174 0.044
muscle structure development GO:0061061 196 0.044
locomotion GO:0040011 313 0.044
morphogenesis of an epithelial sheet GO:0002011 49 0.041
skeletal system morphogenesis GO:0048705 102 0.041
regulation of cytokine production GO:0001817 3 0.040
embryonic skeletal system development GO:0048706 97 0.040
embryo development ending in birth or egg hatching GO:0009792 271 0.039
aging GO:0007568 2 0.037
regulation of cell death GO:0010941 103 0.037
striated muscle cell development GO:0055002 108 0.037
response to organic substance GO:0010033 153 0.037
epithelial cell differentiation GO:0030855 116 0.037
skeletal system development GO:0001501 181 0.037
regulation of protein transport GO:0051223 3 0.036
actin cytoskeleton organization GO:0030036 63 0.036
Worm
fin development GO:0033333 77 0.036
sensory organ development GO:0007423 393 0.035
single organism transport GO:0044765 206 0.035
negative regulation of biological process GO:0048519 304 0.034
negative regulation of protein transport GO:0051224 3 0.033
actin filament based movement GO:0030048 1 0.033
regulation of water loss via skin GO:0033561 1 0.032
water homeostasis GO:0030104 4 0.032
regulation of response to stimulus GO:0048583 269 0.032
generation of neurons GO:0048699 385 0.032
cellular component biogenesis GO:0044085 178 0.032
cellular response to organic cyclic compound GO:0071407 38 0.031
cardiac cell fate commitment GO:0060911 1 0.031
positive regulation of cellular process GO:0048522 201 0.031
cellular response to chemical stimulus GO:0070887 157 0.030
central nervous system neuron differentiation GO:0021953 74 0.030
single organism localization GO:1902578 225 0.029
regulation of muscle contraction GO:0006937 3 0.029
regulation of cell motility GO:2000145 46 0.028
positive regulation of cell cycle GO:0045787 3 0.028
cognition GO:0050890 1 0.028
regulation of vesicle mediated transport GO:0060627 9 0.028
medial fin development GO:0033338 16 0.028
response to glucocorticoid GO:0051384 1 0.028
regulation of cellular component movement GO:0051270 55 0.028
appendage development GO:0048736 80 0.028
regulation of gene expression GO:0010468 265 0.028
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.027
negative regulation of defense response GO:0031348 2 0.027
regulation of cellular component organization GO:0051128 86 0.027
Worm
single organism membrane organization GO:0044802 20 0.027
cellular response to stress GO:0033554 62 0.026
cell surface receptor signaling pathway GO:0007166 325 0.026
specification of axis polarity GO:0065001 4 0.026
embryonic hemopoiesis GO:0035162 53 0.026
connective tissue development GO:0061448 99 0.026
regulation of locomotion GO:0040012 55 0.026
brain development GO:0007420 293 0.026
negative regulation of response to stimulus GO:0048585 104 0.025
nucleic acid metabolic process GO:0090304 244 0.025
response to wounding GO:0009611 116 0.025
cellular component morphogenesis GO:0032989 336 0.025
regulation of membrane potential GO:0042391 23 0.025
vasculature development GO:0001944 278 0.025
embryonic skeletal system morphogenesis GO:0048704 93 0.024
negative regulation of cytokine production GO:0001818 1 0.024
regulation of developmental process GO:0050793 247 0.024
eye morphogenesis GO:0048592 144 0.024
female sex differentiation GO:0046660 4 0.024
complement activation GO:0006956 3 0.024
regulation of metabolic process GO:0019222 359 0.024
cytoskeleton organization GO:0007010 96 0.024
Worm
homeostatic process GO:0042592 142 0.024
regulation of inflammatory response GO:0050727 2 0.023
fatty acid transport GO:0015908 1 0.023
polarized epithelial cell differentiation GO:0030859 4 0.023
fin morphogenesis GO:0033334 53 0.023
heart process GO:0003015 71 0.023
neuronal action potential GO:0019228 18 0.023
response to chemical GO:0042221 320 0.023
cellular protein metabolic process GO:0044267 129 0.023
tissue remodeling GO:0048771 4 0.023
nucleobase containing compound biosynthetic process GO:0034654 205 0.022
angiogenesis GO:0001525 158 0.022
mesoderm development GO:0007498 88 0.022
transport GO:0006810 220 0.022
lateral line system development GO:0048925 76 0.022
epidermis development GO:0008544 48 0.022
specification of symmetry GO:0009799 204 0.022
Zebrafish
digestive system development GO:0055123 289 0.022
actomyosin structure organization GO:0031032 53 0.022
regulation of macromolecule metabolic process GO:0060255 317 0.021
multi organism reproductive process GO:0044703 36 0.021
cartilage development GO:0051216 96 0.021
digestive tract morphogenesis GO:0048546 231 0.021
regulation of organelle organization GO:0033043 29 0.021
Worm
epiboly GO:0090504 41 0.021
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.021
cellular biosynthetic process GO:0044249 286 0.021
actin filament based process GO:0030029 64 0.021
Worm
convergent extension GO:0060026 118 0.021
organelle assembly GO:0070925 110 0.020
protein polymerization GO:0051258 4 0.020
neutrophil homeostasis GO:0001780 1 0.020
convergent extension involved in gastrulation GO:0060027 71 0.020
gastrulation with mouth forming second GO:0001702 44 0.020
multicellular organismal signaling GO:0035637 22 0.020
tube morphogenesis GO:0035239 349 0.020
Zebrafish
cellular component assembly involved in morphogenesis GO:0010927 107 0.020
cell projection organization GO:0030030 284 0.020
protein modification process GO:0036211 100 0.019
central nervous system development GO:0007417 387 0.019
cell cycle g1 s phase transition GO:0044843 1 0.019
erk1 and erk2 cascade GO:0070371 4 0.019
embryonic heart tube development GO:0035050 133 0.019
Zebrafish
membrane organization GO:0061024 21 0.019
negative regulation of epithelial cell proliferation GO:0050680 1 0.019
g1 s transition of mitotic cell cycle GO:0000082 1 0.019
neuron projection development GO:0031175 180 0.018
negative regulation of secretion by cell GO:1903531 2 0.018
lipid storage GO:0019915 1 0.018
apoptotic process GO:0006915 116 0.018
neural crest cell development GO:0014032 62 0.018
cranial nerve development GO:0021545 42 0.018
regulation of programmed cell death GO:0043067 101 0.018
neuroblast proliferation GO:0007405 2 0.018
mesenchyme development GO:0060485 127 0.018
meiotic nuclear division GO:0007126 4 0.018
regulation of apoptotic process GO:0042981 98 0.017
muscle contraction GO:0006936 18 0.017
regulation of cellular biosynthetic process GO:0031326 245 0.017
monoamine transport GO:0015844 1 0.017
organic substance biosynthetic process GO:1901576 289 0.017
negative regulation of cellular process GO:0048523 283 0.017
regulation of wound healing GO:0061041 2 0.017
negative regulation of wnt signaling pathway GO:0030178 30 0.017
regulation of blood coagulation GO:0030193 1 0.017
cellular response to hormone stimulus GO:0032870 39 0.017
death GO:0016265 121 0.017
cellular nitrogen compound biosynthetic process GO:0044271 218 0.017
regulation of cellular metabolic process GO:0031323 320 0.017
regulation of protein ubiquitination GO:0031396 3 0.016
extrinsic apoptotic signaling pathway GO:0097191 3 0.016
cell morphogenesis involved in differentiation GO:0000904 195 0.016
optic nerve development GO:0021554 15 0.016
response to organic cyclic compound GO:0014070 51 0.016
aromatic compound biosynthetic process GO:0019438 217 0.016
regulation of cell activation GO:0050865 1 0.016
organic cyclic compound metabolic process GO:1901360 301 0.016
developmental growth involved in morphogenesis GO:0060560 86 0.016
regulation of protein complex assembly GO:0043254 3 0.016
response to hormone GO:0009725 48 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
behavior GO:0007610 74 0.015
regulation of localization GO:0032879 104 0.015
Worm
cellular protein modification process GO:0006464 100 0.015
retina development in camera type eye GO:0060041 146 0.015
embryonic eye morphogenesis GO:0048048 30 0.015
neural crest cell differentiation GO:0014033 72 0.015
regulation of dna templated transcription in response to stress GO:0043620 0 0.015
protein secretion GO:0009306 1 0.015
programmed cell death GO:0012501 119 0.015
long chain fatty acid metabolic process GO:0001676 1 0.015
heart contraction GO:0060047 71 0.015
regulation of biosynthetic process GO:0009889 250 0.015
neuron differentiation GO:0030182 353 0.015
regulation of multicellular organism growth GO:0040014 4 0.015
homeostasis of number of cells GO:0048872 62 0.015
myeloid cell homeostasis GO:0002262 56 0.015
oxoacid metabolic process GO:0043436 31 0.015
biosynthetic process GO:0009058 294 0.015
macromolecular complex subunit organization GO:0043933 74 0.014
response to external stimulus GO:0009605 264 0.014
macromolecule biosynthetic process GO:0009059 227 0.014
renal system development GO:0072001 94 0.014
kupffer s vesicle development GO:0070121 50 0.014
multicellular organism growth GO:0035264 4 0.014
regulation of epithelial cell proliferation GO:0050678 3 0.014
gene expression GO:0010467 252 0.014
regulation of erk1 and erk2 cascade GO:0070372 4 0.014
regulation of multicellular organismal development GO:2000026 223 0.014
blood vessel development GO:0001568 246 0.014
nerve development GO:0021675 45 0.014
cell morphogenesis GO:0000902 289 0.014
multicellular organismal water homeostasis GO:0050891 1 0.014
wnt signaling pathway GO:0016055 80 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
heterocycle biosynthetic process GO:0018130 215 0.014
reproductive process GO:0022414 40 0.014
cellular macromolecule biosynthetic process GO:0034645 224 0.014
anion transport GO:0006820 38 0.014
cardiocyte differentiation GO:0035051 44 0.014
positive regulation of cellular component biogenesis GO:0044089 3 0.014
adherens junction organization GO:0034332 4 0.014
muscle system process GO:0003012 20 0.014
cellular response to starvation GO:0009267 1 0.013
regulation of epidermis development GO:0045682 2 0.013
fatty acid biosynthetic process GO:0006633 4 0.013
protein metabolic process GO:0019538 183 0.013
striated muscle tissue development GO:0014706 110 0.013
regulation of heart rate GO:0002027 5 0.013
cell aging GO:0007569 2 0.013
gamete generation GO:0007276 33 0.013
regionalization GO:0003002 274 0.013
carboxylic acid metabolic process GO:0019752 22 0.013
neuroblast differentiation GO:0014016 1 0.013
primary neural tube formation GO:0014020 1 0.013
cation transport GO:0006812 81 0.013
protein complex disassembly GO:0043241 1 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
mesendoderm development GO:0048382 10 0.013
cell cycle GO:0007049 93 0.013
nitrogen compound metabolic process GO:0006807 319 0.013
hepaticobiliary system development GO:0061008 98 0.013
stem cell development GO:0048864 82 0.013
regulation of system process GO:0044057 40 0.013
camera type eye development GO:0043010 222 0.013
cellular nitrogen compound metabolic process GO:0034641 290 0.013
protein complex subunit organization GO:0071822 46 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
cell proliferation GO:0008283 80 0.012
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
single organism metabolic process GO:0044710 217 0.012
negative regulation of secretion GO:0051048 2 0.012
organic acid metabolic process GO:0006082 31 0.012
pronephros development GO:0048793 69 0.012
regulation of macromolecule biosynthetic process GO:0010556 225 0.012
stem cell maintenance GO:0019827 4 0.012
digestive tract development GO:0048565 265 0.012
chemical homeostasis GO:0048878 49 0.012
cellular aromatic compound metabolic process GO:0006725 295 0.012
limb bud formation GO:0060174 2 0.012
zymogen activation GO:0031638 3 0.012
hatching GO:0035188 4 0.012
cellular response to organic substance GO:0071310 105 0.012
cartilage condensation GO:0001502 3 0.012
g protein coupled receptor signaling pathway GO:0007186 74 0.012
leukocyte homeostasis GO:0001776 2 0.012
regulation of synapse assembly GO:0051963 3 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
cellular component disassembly GO:0022411 1 0.011
myeloid cell differentiation GO:0030099 86 0.011
heart field specification GO:0003128 1 0.011
long chain fatty acid transport GO:0015909 1 0.011
fertilization GO:0009566 3 0.011
heterocycle metabolic process GO:0046483 290 0.011
retina morphogenesis in camera type eye GO:0060042 79 0.011
leukocyte differentiation GO:0002521 25 0.011
transcription dna templated GO:0006351 181 0.011
rna localization GO:0006403 4 0.011
dna templated transcription elongation GO:0006354 3 0.011
cell migration GO:0016477 237 0.011
mitotic cell cycle GO:0000278 64 0.011
regulation of primary metabolic process GO:0080090 311 0.011
regulation of metal ion transport GO:0010959 4 0.011
muscle tissue development GO:0060537 110 0.011
organic anion transport GO:0015711 15 0.010
regulation of cardiac muscle contraction GO:0055117 2 0.010
positive regulation of epithelial cell migration GO:0010634 2 0.010
cell fate specification GO:0001708 68 0.010
establishment of localization GO:0051234 244 0.010
regulation of nucleic acid templated transcription GO:1903506 213 0.010
regulation of stem cell differentiation GO:2000736 4 0.010
maintenance of location GO:0051235 4 0.010

pkp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.061
cardiovascular system disease DOID:1287 0 0.025
heart disease DOID:114 0 0.025
disease of metabolism DOID:0014667 0 0.022
musculoskeletal system disease DOID:17 0 0.019
muscular disease DOID:0080000 0 0.015
myopathy DOID:423 0 0.014
cardiomyopathy DOID:0050700 0 0.014
muscle tissue disease DOID:66 0 0.014
intrinsic cardiomyopathy DOID:0060036 0 0.011