Danio rerio

0 known processes

pkp3

plakophilin 3

(Aliases: wu:fk69a12,MGC136656,zgc:136656,wu:fa97f09,MGC174236)

pkp3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
desmosome organization GO:0002934 3 0.403
desmosome assembly GO:0002159 2 0.401
keratinocyte differentiation GO:0030216 0 0.313
heart development GO:0007507 313 0.251
cell motility GO:0048870 244 0.231
embryonic organ development GO:0048568 381 0.216
pigment cell differentiation GO:0050931 38 0.200
regulation of establishment of protein localization GO:0070201 4 0.198
cellular component assembly GO:0022607 170 0.191
cartilage development GO:0051216 96 0.189
embryonic organ morphogenesis GO:0048562 274 0.172
hemopoiesis GO:0030097 183 0.168
regulation of locomotion GO:0040012 55 0.165
epidermis development GO:0008544 48 0.157
regulation of protein transport GO:0051223 3 0.148
protein secretion GO:0009306 1 0.144
response to organic substance GO:0010033 153 0.136
retina development in camera type eye GO:0060041 146 0.131
regulation of biological quality GO:0065008 263 0.122
hematopoietic or lymphoid organ development GO:0048534 191 0.118
actin filament based movement GO:0030048 1 0.115
positive regulation of biological process GO:0048518 253 0.108
cognition GO:0050890 1 0.105
neuron neuron synaptic transmission GO:0007270 1 0.102
skin development GO:0043588 54 0.101
digestive system development GO:0055123 289 0.101
head development GO:0060322 303 0.095
locomotion GO:0040011 313 0.091
eye development GO:0001654 277 0.089
positive regulation of transport GO:0051050 2 0.089
apoptotic process GO:0006915 116 0.085
tube morphogenesis GO:0035239 349 0.084
central nervous system development GO:0007417 387 0.080
cellular component movement GO:0006928 335 0.080
regulation of developmental process GO:0050793 247 0.080
negative regulation of protein transport GO:0051224 3 0.079
immune system development GO:0002520 191 0.077
inner ear development GO:0048839 126 0.077
adherens junction organization GO:0034332 4 0.076
growth GO:0040007 174 0.075
regulation of membrane potential GO:0042391 23 0.072
digestive tract development GO:0048565 265 0.071
morphogenesis of an epithelium GO:0002009 333 0.069
convergent extension GO:0060026 118 0.068
regulation of apoptotic process GO:0042981 98 0.068
brain development GO:0007420 293 0.067
larval development GO:0002164 2 0.066
organelle organization GO:0006996 227 0.065
multicellular organismal signaling GO:0035637 22 0.063
single organism nuclear import GO:1902593 3 0.063
single fertilization GO:0007338 3 0.063
embryo development ending in birth or egg hatching GO:0009792 271 0.061
regulation of metabolic process GO:0019222 359 0.060
regulation of multicellular organismal process GO:0051239 277 0.060
response to uv GO:0009411 3 0.059
single organism organelle organization GO:1902589 199 0.058
regulation of cytokine production GO:0001817 3 0.057
tissue remodeling GO:0048771 4 0.056
cellular component biogenesis GO:0044085 178 0.055
developmental pigmentation GO:0048066 48 0.055
action potential GO:0001508 19 0.054
gtp catabolic process GO:0006184 2 0.053
digestive tract morphogenesis GO:0048546 231 0.053
regulation of primary metabolic process GO:0080090 311 0.052
regulation of muscle contraction GO:0006937 3 0.052
pigmentation GO:0043473 85 0.051
myeloid cell homeostasis GO:0002262 56 0.050
regulation of epithelial cell proliferation GO:0050678 3 0.050
convergent extension involved in gastrulation GO:0060027 71 0.050
cellular response to external stimulus GO:0071496 2 0.050
regulation of cell death GO:0010941 103 0.050
cellular response to decreased oxygen levels GO:0036294 1 0.049
response to corticosteroid GO:0031960 1 0.049
regulation of multicellular organismal development GO:2000026 223 0.049
stem cell maintenance GO:0019827 4 0.049
cell junction organization GO:0034330 11 0.049
cellular response to starvation GO:0009267 1 0.048
mesenchyme development GO:0060485 127 0.048
neural crest cell development GO:0014032 62 0.048
embryonic skeletal system morphogenesis GO:0048704 93 0.047
cellular nitrogen compound metabolic process GO:0034641 290 0.047
gastrulation GO:0007369 208 0.046
carbohydrate biosynthetic process GO:0016051 1 0.046
fin development GO:0033333 77 0.046
homeostatic process GO:0042592 142 0.046
epithelial tube morphogenesis GO:0060562 148 0.045
homeostasis of number of cells GO:0048872 62 0.045
cellular component maintenance GO:0043954 3 0.045
protein import into nucleus GO:0006606 3 0.044
gland development GO:0048732 143 0.043
tissue regeneration GO:0042246 74 0.043
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.043
death GO:0016265 121 0.042
cellular response to oxygen levels GO:0071453 1 0.042
epidermal cell differentiation GO:0009913 36 0.042
organelle assembly GO:0070925 110 0.041
heart morphogenesis GO:0003007 156 0.041
transmission of nerve impulse GO:0019226 19 0.041
regulation of cell motility GO:2000145 46 0.039
signal transduction GO:0007165 455 0.039
nitrogen compound metabolic process GO:0006807 319 0.039
hepaticobiliary system development GO:0061008 98 0.039
regulation of cytoplasmic transport GO:1903649 4 0.039
liver development GO:0001889 96 0.038
ear development GO:0043583 127 0.038
regulation of synapse assembly GO:0051963 3 0.038
phagocytosis GO:0006909 3 0.037
stem cell proliferation GO:0072089 4 0.036
neuroblast proliferation GO:0007405 2 0.036
localization of cell GO:0051674 244 0.036
immune system process GO:0002376 241 0.036
programmed cell death GO:0012501 119 0.035
cellular macromolecule metabolic process GO:0044260 391 0.035
cardiac conduction GO:0061337 3 0.035
positive regulation of cell cycle GO:0045787 3 0.035
cellular aromatic compound metabolic process GO:0006725 295 0.035
regeneration GO:0031099 91 0.034
axial mesoderm morphogenesis GO:0048319 8 0.034
skeletal system morphogenesis GO:0048705 102 0.034
heart looping GO:0001947 94 0.034
transport GO:0006810 220 0.034
response to glucocorticoid GO:0051384 1 0.033
morphogenesis of an epithelial sheet GO:0002011 49 0.033
embryonic heart tube development GO:0035050 133 0.033
establishment of protein localization to organelle GO:0072594 4 0.033
protein localization to nucleus GO:0034504 3 0.033
regulation of nervous system development GO:0051960 90 0.032
cell migration GO:0016477 237 0.032
negative regulation of cellular process GO:0048523 283 0.032
regulation of cellular metabolic process GO:0031323 320 0.032
stem cell differentiation GO:0048863 117 0.032
organic cyclic compound metabolic process GO:1901360 301 0.032
regulation of nucleoside metabolic process GO:0009118 2 0.031
extrinsic apoptotic signaling pathway GO:0097191 3 0.031
gtp metabolic process GO:0046039 4 0.031
inner ear morphogenesis GO:0042472 63 0.031
positive regulation of catabolic process GO:0009896 4 0.030
cell cell junction organization GO:0045216 10 0.030
regulation of nitrogen compound metabolic process GO:0051171 251 0.030
response to abiotic stimulus GO:0009628 122 0.030
developmental growth GO:0048589 166 0.030
protein metabolic process GO:0019538 183 0.030
gene expression GO:0010467 252 0.030
determination of heart left right asymmetry GO:0061371 117 0.030
leukocyte homeostasis GO:0001776 2 0.029
multicellular organism growth GO:0035264 4 0.029
negative regulation of cytokine production GO:0001818 1 0.029
guanosine containing compound catabolic process GO:1901069 2 0.029
nuclear transport GO:0051169 4 0.029
cell projection organization GO:0030030 284 0.029
cellular component morphogenesis GO:0032989 336 0.029
synaptic growth at neuromuscular junction GO:0051124 2 0.029
positive regulation of secretion GO:0051047 1 0.029
negative regulation of biological process GO:0048519 304 0.029
cardiocyte differentiation GO:0035051 44 0.028
neural crest cell differentiation GO:0014033 72 0.028
appendage development GO:0048736 80 0.028
regulation of programmed cell death GO:0043067 101 0.028
positive regulation of cellular catabolic process GO:0031331 3 0.028
heterocycle metabolic process GO:0046483 290 0.028
connective tissue development GO:0061448 99 0.027
myeloid cell differentiation GO:0030099 86 0.027
cell projection morphogenesis GO:0048858 244 0.027
positive regulation of secretion by cell GO:1903532 1 0.027
protein targeting to nucleus GO:0044744 3 0.027
fatty acid transport GO:0015908 1 0.027
regulation of protein localization to nucleus GO:1900180 2 0.027
regulation of actin filament based movement GO:1903115 1 0.027
generation of neurons GO:0048699 385 0.026
embryonic cranial skeleton morphogenesis GO:0048701 90 0.026
regulation of synapse organization GO:0050807 3 0.026
aging GO:0007568 2 0.026
neuronal action potential GO:0019228 18 0.026
regulation of cellular ketone metabolic process GO:0010565 7 0.026
regulation of system process GO:0044057 40 0.026
response to drug GO:0042493 3 0.026
wound healing GO:0042060 90 0.026
cell death GO:0008219 121 0.026
multi organism process GO:0051704 134 0.026
sensory organ development GO:0007423 393 0.025
water homeostasis GO:0030104 4 0.025
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.025
regulation of intracellular protein transport GO:0033157 3 0.025
nucleic acid metabolic process GO:0090304 244 0.025
regulation of reproductive process GO:2000241 4 0.025
regulation of multicellular organism growth GO:0040014 4 0.025
regulation of response to stimulus GO:0048583 269 0.025
adherens junction maintenance GO:0034334 2 0.024
chordate embryonic development GO:0043009 271 0.024
actin filament based process GO:0030029 64 0.024
regulation of nucleocytoplasmic transport GO:0046822 2 0.024
regulation of cellular biosynthetic process GO:0031326 245 0.024
regulation of heart contraction GO:0008016 32 0.024
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.024
cell fate specification GO:0001708 68 0.023
regulation of protein import into nucleus GO:0042306 2 0.023
membrane invagination GO:0010324 1 0.023
wnt signaling pathway GO:0016055 80 0.023
cell morphogenesis GO:0000902 289 0.023
female sex differentiation GO:0046660 4 0.023
urogenital system development GO:0001655 97 0.023
negative regulation of response to stimulus GO:0048585 104 0.022
pronephros development GO:0048793 69 0.022
rna metabolic process GO:0016070 219 0.022
cell cell adhesion involved in mesendodermal cell migration GO:0003370 1 0.022
neurological system process GO:0050877 62 0.022
polarized epithelial cell differentiation GO:0030859 4 0.022
epithelial cell differentiation GO:0030855 116 0.022
medial fin development GO:0033338 16 0.022
negative regulation of cell communication GO:0010648 96 0.022
energy reserve metabolic process GO:0006112 2 0.021
regulation of nucleic acid templated transcription GO:1903506 213 0.021
regulation of cellular component movement GO:0051270 55 0.021
single organism localization GO:1902578 225 0.021
cell proliferation GO:0008283 80 0.021
regulation of protein targeting GO:1903533 2 0.021
blood circulation GO:0008015 87 0.021
cellular protein metabolic process GO:0044267 129 0.021
sexual reproduction GO:0019953 36 0.021
fin morphogenesis GO:0033334 53 0.021
system process GO:0003008 185 0.021
regulation of gene expression GO:0010468 265 0.021
cellular response to organic substance GO:0071310 105 0.021
cellular response to hormone stimulus GO:0032870 39 0.021
nucleocytoplasmic transport GO:0006913 4 0.021
embryonic heart tube morphogenesis GO:0003143 108 0.021
meiotic nuclear division GO:0007126 4 0.020
single organism metabolic process GO:0044710 217 0.020
skeletal system development GO:0001501 181 0.020
regulation of localization GO:0032879 104 0.020
cellular component assembly involved in morphogenesis GO:0010927 107 0.020
positive regulation of neuron apoptotic process GO:0043525 1 0.020
regulation of organ morphogenesis GO:2000027 35 0.020
ventricular cardiac muscle tissue development GO:0003229 3 0.020
g1 s transition of mitotic cell cycle GO:0000082 1 0.020
small gtpase mediated signal transduction GO:0007264 8 0.020
developmental programmed cell death GO:0010623 4 0.020
response to lipid GO:0033993 60 0.020
stem cell development GO:0048864 82 0.019
negative regulation of epithelial cell proliferation GO:0050680 1 0.019
regulation of epidermis development GO:0045682 2 0.019
phosphate containing compound metabolic process GO:0006796 108 0.019
regulation of biosynthetic process GO:0009889 250 0.019
neural crest cell migration GO:0001755 42 0.019
cell surface receptor signaling pathway GO:0007166 325 0.019
vasculogenesis GO:0001570 41 0.019
cell fate commitment GO:0045165 99 0.018
cellular response to hypoxia GO:0071456 1 0.018
response to chemical GO:0042221 320 0.018
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.018
guanosine containing compound metabolic process GO:1901068 4 0.018
ras protein signal transduction GO:0007265 7 0.018
positive regulation of macromolecule metabolic process GO:0010604 93 0.018
regulation of cellular component organization GO:0051128 86 0.018
negative regulation of stem cell differentiation GO:2000737 2 0.018
nuclear migration GO:0007097 3 0.018
single organism transport GO:0044765 206 0.018
protein import GO:0017038 3 0.018
neuron differentiation GO:0030182 353 0.018
axis elongation involved in somitogenesis GO:0090245 2 0.018
establishment of localization in cell GO:0051649 77 0.018
sleep GO:0030431 1 0.017
protein localization GO:0008104 40 0.017
cellular response to nutrient levels GO:0031669 2 0.017
meiosis i GO:0007127 1 0.017
regulation of synaptic plasticity GO:0048167 1 0.017
camera type eye development GO:0043010 222 0.017
response to endogenous stimulus GO:0009719 83 0.017
regulation of purine nucleotide catabolic process GO:0033121 2 0.017
epiboly GO:0090504 41 0.017
establishment of localization GO:0051234 244 0.017
positive regulation of cellular process GO:0048522 201 0.017
ear morphogenesis GO:0042471 64 0.017
protein complex disassembly GO:0043241 1 0.017
positive regulation of cell death GO:0010942 29 0.017
peripheral nervous system development GO:0007422 55 0.017
cellular component disassembly GO:0022411 1 0.017
regulation of cell cycle GO:0051726 52 0.017
regionalization GO:0003002 274 0.017
regulation of gtpase activity GO:0043087 2 0.016
autophagy GO:0006914 4 0.016
response to hormone GO:0009725 48 0.016
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.016
negative regulation of defense response GO:0031348 2 0.016
cortical cytoskeleton organization GO:0030865 1 0.016
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.016
amine metabolic process GO:0009308 2 0.016
nucleobase containing compound metabolic process GO:0006139 274 0.016
leukocyte differentiation GO:0002521 25 0.016
intracellular signal transduction GO:0035556 85 0.016
cellular nitrogen compound biosynthetic process GO:0044271 218 0.016
neuroblast differentiation GO:0014016 1 0.016
nuclear import GO:0051170 3 0.016
determination of bilateral symmetry GO:0009855 204 0.016
actin mediated cell contraction GO:0070252 1 0.015
transcription from rna polymerase ii promoter GO:0006366 80 0.015
heart contraction GO:0060047 71 0.015
cardiac cell fate commitment GO:0060911 1 0.015
multicellular organismal macromolecule metabolic process GO:0044259 2 0.015
regulation of cell projection assembly GO:0060491 4 0.015
circulatory system process GO:0003013 87 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
pectoral fin morphogenesis GO:0035138 29 0.015
plasma membrane repair GO:0001778 2 0.015
cartilage condensation GO:0001502 3 0.015
cellular response to organic cyclic compound GO:0071407 38 0.015
exocytosis GO:0006887 1 0.015
cell cycle g1 s phase transition GO:0044843 1 0.015
regulation of stem cell differentiation GO:2000736 4 0.015
regulation of rna metabolic process GO:0051252 224 0.015
regulation of autophagy GO:0010506 3 0.015
specification of organ identity GO:0010092 2 0.015
reactive nitrogen species metabolic process GO:2001057 0 0.015
protein modification process GO:0036211 100 0.014
phosphorus metabolic process GO:0006793 109 0.014
regulation of reactive oxygen species metabolic process GO:2000377 2 0.014
regulation of eye photoreceptor cell development GO:0042478 2 0.014
response to wounding GO:0009611 116 0.014
response to organic cyclic compound GO:0014070 51 0.014
eye morphogenesis GO:0048592 144 0.014
macromolecule localization GO:0033036 54 0.014
determination of left right symmetry GO:0007368 179 0.014
renal system development GO:0072001 94 0.014
regulation of carbohydrate biosynthetic process GO:0043255 1 0.014
anion transport GO:0006820 38 0.014
reactive oxygen species biosynthetic process GO:1903409 1 0.014
response to nitrogen compound GO:1901698 19 0.014
positive regulation of cellular metabolic process GO:0031325 94 0.014
regulation of hydrolase activity GO:0051336 28 0.014
reciprocal meiotic recombination GO:0007131 1 0.014
cellular localization GO:0051641 97 0.013
cytoskeleton organization GO:0007010 96 0.013
regulation of signal transduction GO:0009966 225 0.013
retina morphogenesis in camera type eye GO:0060042 79 0.013
renal system process involved in regulation of blood volume GO:0001977 1 0.013
erythrocyte development GO:0048821 24 0.013
small molecule metabolic process GO:0044281 77 0.013
positive regulation of cellular component biogenesis GO:0044089 3 0.013
positive regulation of gtp catabolic process GO:0033126 1 0.013
heart process GO:0003015 71 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
cytokinesis GO:0000910 3 0.013
regulation of protein catabolic process GO:0042176 1 0.013
regulation of circadian sleep wake cycle GO:0042749 1 0.013
somatic stem cell maintenance GO:0035019 1 0.013
regulation of gtp catabolic process GO:0033124 2 0.013
biosynthetic process GO:0009058 294 0.013
response to fluid shear stress GO:0034405 2 0.013
regulation of photoreceptor cell differentiation GO:0046532 2 0.013
cell projection assembly GO:0030031 64 0.013
gamete generation GO:0007276 33 0.013
erythrocyte homeostasis GO:0034101 55 0.013
regulation of cell differentiation GO:0045595 142 0.013
cell junction maintenance GO:0034331 2 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.013
neutrophil homeostasis GO:0001780 1 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
pancreas development GO:0031016 84 0.013
cellular response to extracellular stimulus GO:0031668 2 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
regulation of blood circulation GO:1903522 32 0.012
anterior posterior pattern specification GO:0009952 152 0.012
positive regulation of programmed cell death GO:0043068 29 0.012
zymogen activation GO:0031638 3 0.012
regulation of macromolecule metabolic process GO:0060255 317 0.012
regulation of cell migration GO:0030334 40 0.012
muscle structure development GO:0061061 196 0.012
monoamine transport GO:0015844 1 0.012
mesoderm development GO:0007498 88 0.012
embryonic hemopoiesis GO:0035162 53 0.012
sensory system development GO:0048880 76 0.012
regulation of circadian rhythm GO:0042752 4 0.012
macromolecular complex disassembly GO:0032984 1 0.012
oxoacid metabolic process GO:0043436 31 0.012
positive regulation of apoptotic process GO:0043065 29 0.012
proximal distal pattern formation GO:0009954 1 0.011
blood vessel development GO:0001568 246 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
long chain fatty acid transport GO:0015909 1 0.011
cell cycle GO:0007049 93 0.011
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.011
kidney development GO:0001822 92 0.011
cell part morphogenesis GO:0032990 246 0.011
regulation of blood vessel size GO:0050880 2 0.011
positive regulation of ras protein signal transduction GO:0046579 1 0.011
response to nutrient GO:0007584 3 0.011
macromolecule modification GO:0043412 111 0.011
skeletal muscle fiber development GO:0048741 35 0.011
meiotic cell cycle process GO:1903046 3 0.011
regulation of cardiac muscle contraction GO:0055117 2 0.011
cranial nerve development GO:0021545 42 0.011
reproductive process GO:0022414 40 0.011
cellular response to light stimulus GO:0071482 4 0.011
neutrophil mediated immunity GO:0002446 1 0.011
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.011
cardiac muscle cell contraction GO:0086003 1 0.011
pectoral fin development GO:0033339 50 0.011
smooth muscle contraction GO:0006939 2 0.011
negative regulation of response to cytokine stimulus GO:0060761 2 0.011
maintenance of location GO:0051235 4 0.010
cell type specific apoptotic process GO:0097285 22 0.010
kupffer s vesicle development GO:0070121 50 0.010
adult behavior GO:0030534 2 0.010
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.010
mitotic cell cycle GO:0000278 64 0.010
cellular response to xenobiotic stimulus GO:0071466 35 0.010
response to inorganic substance GO:0010035 38 0.010
negative regulation of multicellular organismal process GO:0051241 69 0.010
phagocytosis engulfment GO:0006911 1 0.010
specification of symmetry GO:0009799 204 0.010
lateral line system development GO:0048925 76 0.010
developmental process involved in reproduction GO:0003006 27 0.010
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.010
appendage morphogenesis GO:0035107 56 0.010
semicircular canal development GO:0060872 24 0.010
regulation of tube size GO:0035150 2 0.010

pkp3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.046
myopathy DOID:423 0 0.034
muscular disease DOID:0080000 0 0.034
heart disease DOID:114 0 0.034
cardiomyopathy DOID:0050700 0 0.034
cardiovascular system disease DOID:1287 0 0.034
musculoskeletal system disease DOID:17 0 0.034
muscle tissue disease DOID:66 0 0.034
intrinsic cardiomyopathy DOID:0060036 0 0.023
disease of metabolism DOID:0014667 0 0.021
amyloidosis DOID:9120 0 0.021
acquired metabolic disease DOID:0060158 0 0.021
disease of cellular proliferation DOID:14566 0 0.012