Danio rerio

0 known processes

plod2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

(Aliases: zgc:101868,MGC101868,lh2)

plod2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular component morphogenesis GO:0032989 336 0.670
Zebrafish
embryonic organ morphogenesis GO:0048562 274 0.650
embryonic organ development GO:0048568 381 0.616
cell morphogenesis involved in differentiation GO:0000904 195 0.570
Zebrafish
collagen biosynthetic process GO:0032964 2 0.466
Worm
mesenchymal cell development GO:0014031 78 0.429
Zebrafish
chordate embryonic development GO:0043009 271 0.378
skeletal system morphogenesis GO:0048705 102 0.357
skeletal system development GO:0001501 181 0.347
cellular biosynthetic process GO:0044249 286 0.320
Worm
biosynthetic process GO:0009058 294 0.309
Worm
cell morphogenesis GO:0000902 289 0.303
Zebrafish
connective tissue development GO:0061448 99 0.260
glycoprotein metabolic process GO:0009100 23 0.252
Worm
nitrogen compound metabolic process GO:0006807 319 0.247
Worm
morphogenesis of an epithelium GO:0002009 333 0.242
notochord development GO:0030903 54 0.241
organic substance biosynthetic process GO:1901576 289 0.230
Worm
cartilage development GO:0051216 96 0.227
heart morphogenesis GO:0003007 156 0.213
cellular aromatic compound metabolic process GO:0006725 295 0.201
Worm
tissue remodeling GO:0048771 4 0.196
collagen metabolic process GO:0032963 2 0.194
Worm
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.189
angiogenesis GO:0001525 158 0.181
cellular macromolecule biosynthetic process GO:0034645 224 0.179
Worm
vasculature development GO:0001944 278 0.176
embryonic cranial skeleton morphogenesis GO:0048701 90 0.173
embryonic skeletal system development GO:0048706 97 0.173
regulation of multicellular organismal process GO:0051239 277 0.172
macromolecule biosynthetic process GO:0009059 227 0.167
Worm
regulation of metabolic process GO:0019222 359 0.155
cellular macromolecule metabolic process GO:0044260 391 0.153
Worm
regulation of primary metabolic process GO:0080090 311 0.137
embryo development ending in birth or egg hatching GO:0009792 271 0.135
Worm
heart development GO:0007507 313 0.133
regulation of response to stimulus GO:0048583 269 0.132
stem cell development GO:0048864 82 0.131
Zebrafish
positive regulation of transport GO:0051050 2 0.131
heart looping GO:0001947 94 0.120
organic cyclic compound metabolic process GO:1901360 301 0.119
Worm
nucleobase containing compound metabolic process GO:0006139 274 0.119
Worm
mesenchyme development GO:0060485 127 0.118
Zebrafish
multicellular organismal macromolecule metabolic process GO:0044259 2 0.116
Worm
larval development GO:0002164 2 0.115
Worm
heterocycle biosynthetic process GO:0018130 215 0.113
cellular nitrogen compound metabolic process GO:0034641 290 0.113
Worm
heterocycle metabolic process GO:0046483 290 0.110
Worm
epithelial cell morphogenesis GO:0003382 2 0.106
embryonic viscerocranium morphogenesis GO:0048703 52 0.106
regulation of nitrogen compound metabolic process GO:0051171 251 0.105
regulation of bone mineralization GO:0030500 2 0.103
kidney development GO:0001822 92 0.091
transcription dna templated GO:0006351 181 0.090
positive regulation of cellular process GO:0048522 201 0.090
signal transduction GO:0007165 455 0.089
blood vessel morphogenesis GO:0048514 216 0.088
collagen fibril organization GO:0030199 1 0.087
single organism metabolic process GO:0044710 217 0.085
Worm
gene expression GO:0010467 252 0.084
cell projection morphogenesis GO:0048858 244 0.084
Zebrafish
rna biosynthetic process GO:0032774 181 0.083
regulation of macromolecule metabolic process GO:0060255 317 0.081
multicellular organismal metabolic process GO:0044236 2 0.080
Worm
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.078
neural crest cell differentiation GO:0014033 72 0.077
Zebrafish
tube morphogenesis GO:0035239 349 0.075
embryonic skeletal system morphogenesis GO:0048704 93 0.074
regulation of signaling GO:0023051 235 0.072
specification of symmetry GO:0009799 204 0.070
axon development GO:0061564 166 0.070
Zebrafish
epithelial tube morphogenesis GO:0060562 148 0.070
organic cyclic compound biosynthetic process GO:1901362 223 0.069
embryonic skeletal joint development GO:0072498 3 0.068
localization of cell GO:0051674 244 0.068
Zebrafish
establishment of protein localization to organelle GO:0072594 4 0.067
bone mineralization GO:0030282 9 0.067
regulation of signal transduction GO:0009966 225 0.066
establishment of localization GO:0051234 244 0.065
Worm
axonogenesis GO:0007409 152 0.064
Zebrafish
modification dependent protein catabolic process GO:0019941 3 0.064
nucleic acid templated transcription GO:0097659 181 0.063
regulation of biosynthetic process GO:0009889 250 0.062
small molecule metabolic process GO:0044281 77 0.062
Worm
regulation of multicellular organismal development GO:2000026 223 0.061
cell motility GO:0048870 244 0.060
Zebrafish
regulation of biomineral tissue development GO:0070167 2 0.060
muscle cell development GO:0055001 115 0.059
regulation of protein catabolic process GO:0042176 1 0.057
cartilage condensation GO:0001502 3 0.056
regulation of organ morphogenesis GO:2000027 35 0.055
embryonic skeletal joint morphogenesis GO:0060272 3 0.054
sulfur compound metabolic process GO:0006790 13 0.054
ubiquitin dependent protein catabolic process GO:0006511 3 0.053
cellular nitrogen compound biosynthetic process GO:0044271 218 0.052
nucleobase containing small molecule metabolic process GO:0055086 32 0.052
Worm
ameboidal type cell migration GO:0001667 143 0.052
Zebrafish
carbohydrate derivative biosynthetic process GO:1901137 43 0.050
Worm
sprouting angiogenesis GO:0002040 53 0.050
mesenchymal cell differentiation GO:0048762 87 0.050
Zebrafish
sensory organ morphogenesis GO:0090596 200 0.048
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.048
ear morphogenesis GO:0042471 64 0.047
cellular protein catabolic process GO:0044257 4 0.046
positive regulation of cellular catabolic process GO:0031331 3 0.046
regulation of epithelial cell proliferation GO:0050678 3 0.045
embryonic heart tube development GO:0035050 133 0.045
regulation of rna metabolic process GO:0051252 224 0.043
positive regulation of rna biosynthetic process GO:1902680 57 0.043
growth plate cartilage development GO:0003417 2 0.043
enzyme linked receptor protein signaling pathway GO:0007167 106 0.041
regulation of cellular biosynthetic process GO:0031326 245 0.041
regionalization GO:0003002 274 0.041
regulation of smoothened signaling pathway GO:0008589 18 0.040
brain development GO:0007420 293 0.039
cell surface receptor signaling pathway GO:0007166 325 0.039
blood vessel development GO:0001568 246 0.038
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.038
cell projection organization GO:0030030 284 0.038
Zebrafish
embryonic heart tube morphogenesis GO:0003143 108 0.038
eye morphogenesis GO:0048592 144 0.037
head development GO:0060322 303 0.037
regulation of localization GO:0032879 104 0.036
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.036
Zebrafish
cranial ganglion development GO:0061550 3 0.036
proteasomal protein catabolic process GO:0010498 2 0.036
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.036
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.035
growth GO:0040007 174 0.034
appendage morphogenesis GO:0035107 56 0.034
Zebrafish
urogenital system development GO:0001655 97 0.034
determination of heart left right asymmetry GO:0061371 117 0.034
aging GO:0007568 2 0.034
regulation of glial cell differentiation GO:0045685 4 0.033
pronephros development GO:0048793 69 0.033
carbohydrate derivative metabolic process GO:1901135 61 0.032
Worm
regulation of protein localization to nucleus GO:1900180 2 0.032
regulation of gene expression GO:0010468 265 0.032
nephron development GO:0072006 31 0.032
wnt signaling pathway GO:0016055 80 0.032
mitotic dna damage checkpoint GO:0044773 4 0.032
protein metabolic process GO:0019538 183 0.032
Worm
single organism nuclear import GO:1902593 3 0.032
system process GO:0003008 185 0.031
nuclear transport GO:0051169 4 0.031
regulation of cellular metabolic process GO:0031323 320 0.031
multicellular organism growth GO:0035264 4 0.031
glycoprotein biosynthetic process GO:0009101 21 0.031
Worm
single organism localization GO:1902578 225 0.031
Worm
epithelial to mesenchymal transition GO:0001837 21 0.030
nucleocytoplasmic transport GO:0006913 4 0.030
stem cell differentiation GO:0048863 117 0.030
Zebrafish
morphogenesis of a branching structure GO:0001763 21 0.030
central nervous system development GO:0007417 387 0.029
regulation of cell communication GO:0010646 232 0.029
regulation of binding GO:0051098 3 0.029
notochord morphogenesis GO:0048570 17 0.029
cell part morphogenesis GO:0032990 246 0.029
Zebrafish
nucleic acid metabolic process GO:0090304 244 0.029
regulation of cytoplasmic transport GO:1903649 4 0.029
regulation of nucleic acid templated transcription GO:1903506 213 0.029
regulation of transcription dna templated GO:0006355 213 0.029
heart jogging GO:0003146 40 0.029
embryonic limb morphogenesis GO:0030326 2 0.029
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.028
positive regulation of cell differentiation GO:0045597 30 0.028
locomotion GO:0040011 313 0.028
Zebrafish
bmp signaling pathway GO:0030509 52 0.028
regulation of tube size GO:0035150 2 0.028
renal system development GO:0072001 94 0.028
regulation of developmental process GO:0050793 247 0.027
negative regulation of cytokine production GO:0001818 1 0.027
positive regulation of signaling GO:0023056 56 0.027
motor neuron axon guidance GO:0008045 23 0.027
Zebrafish
regulation of calcium ion transport GO:0051924 2 0.026
patterning of blood vessels GO:0001569 15 0.026
regulation of myotube differentiation GO:0010830 2 0.026
regulation of cell development GO:0060284 100 0.025
bone remodeling GO:0046849 2 0.025
neural crest cell development GO:0014032 62 0.025
Zebrafish
transport GO:0006810 220 0.025
Worm
regulation of intracellular protein transport GO:0033157 3 0.025
camera type eye morphogenesis GO:0048593 108 0.025
regulation of nucleocytoplasmic transport GO:0046822 2 0.025
regulation of protein transport GO:0051223 3 0.025
chondrocyte development GO:0002063 4 0.025
regulation of mitotic cell cycle GO:0007346 25 0.024
glial cell proliferation GO:0014009 4 0.024
modification dependent macromolecule catabolic process GO:0043632 3 0.024
cellular component biogenesis GO:0044085 178 0.024
notochord cell differentiation GO:0060034 18 0.024
neural crest cell migration GO:0001755 42 0.024
Zebrafish
determination of left right symmetry GO:0007368 179 0.024
regulation of anatomical structure morphogenesis GO:0022603 130 0.024
eye development GO:0001654 277 0.024
nucleobase containing compound biosynthetic process GO:0034654 205 0.024
glial cell migration GO:0008347 3 0.024
determination of bilateral symmetry GO:0009855 204 0.023
regulation of protein import into nucleus GO:0042306 2 0.023
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
circulatory system process GO:0003013 87 0.023
glycosylation GO:0070085 11 0.022
Worm
aromatic compound biosynthetic process GO:0019438 217 0.022
regulation of protein targeting GO:1903533 2 0.022
positive regulation of embryonic development GO:0040019 3 0.022
branchiomotor neuron axon guidance GO:0021785 1 0.022
maintenance of location GO:0051235 4 0.022
nephron tubule morphogenesis GO:0072078 1 0.022
dorsal ventral pattern formation GO:0009953 125 0.022
trabecula morphogenesis GO:0061383 2 0.022
regulation of rna biosynthetic process GO:2001141 213 0.021
negative regulation of multicellular organismal process GO:0051241 69 0.021
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.021
biomineral tissue development GO:0031214 13 0.021
organonitrogen compound metabolic process GO:1901564 74 0.021
protein import into nucleus GO:0006606 3 0.021
somite development GO:0061053 96 0.021
positive regulation of apoptotic signaling pathway GO:2001235 1 0.021
single organism transport GO:0044765 206 0.021
Worm
midbrain development GO:0030901 28 0.020
regulation of macromolecule biosynthetic process GO:0010556 225 0.020
regulation of metal ion transport GO:0010959 4 0.020
protein targeting to nucleus GO:0044744 3 0.020
cell cycle g1 s phase transition GO:0044843 1 0.020
primary neural tube formation GO:0014020 1 0.019
positive regulation of catabolic process GO:0009896 4 0.019
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.019
cellular response to external stimulus GO:0071496 2 0.019
nitric oxide metabolic process GO:0046209 2 0.019
autonomic nervous system development GO:0048483 19 0.019
glial cell fate commitment GO:0021781 6 0.019
central nervous system neuron differentiation GO:0021953 74 0.019
cellular localization GO:0051641 97 0.019
Worm
developmental growth involved in morphogenesis GO:0060560 86 0.019
positive regulation of cellular biosynthetic process GO:0031328 68 0.018
regulation of multicellular organism growth GO:0040014 4 0.018
response to fluid shear stress GO:0034405 2 0.018
odontogenesis of dentin containing tooth GO:0042475 1 0.018
cardiac chamber development GO:0003205 19 0.018
ossification GO:0001503 23 0.018
positive regulation of biological process GO:0048518 253 0.018
leukocyte proliferation GO:0070661 1 0.018
smoothened signaling pathway GO:0007224 30 0.018
regulation of blood vessel size GO:0050880 2 0.018
g1 s transition of mitotic cell cycle GO:0000082 1 0.017
regulation of multicellular organismal metabolic process GO:0044246 2 0.017
protein modification process GO:0036211 100 0.017
Worm
regulation of skeletal muscle fiber development GO:0048742 2 0.017
cell proliferation in hindbrain GO:0021534 4 0.017
transcription from rna polymerase ii promoter GO:0006366 80 0.017
regulation of stem cell differentiation GO:2000736 4 0.017
response to external stimulus GO:0009605 264 0.017
Zebrafish
cell adhesion mediated by integrin GO:0033627 1 0.017
lymphocyte proliferation GO:0046651 1 0.017
muscle tissue development GO:0060537 110 0.017
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.017
organic acid metabolic process GO:0006082 31 0.017
adult behavior GO:0030534 2 0.017
pronephric nephron tubule development GO:0039020 2 0.017
convergent extension GO:0060026 118 0.017
i kappab kinase nf kappab signaling GO:0007249 4 0.017
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
programmed cell death GO:0012501 119 0.016
death GO:0016265 121 0.016
endochondral bone growth GO:0003416 2 0.016
aminoglycan metabolic process GO:0006022 9 0.016
positive regulation of epithelial cell proliferation GO:0050679 1 0.016
facial nerve development GO:0021561 3 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
peptide transport GO:0015833 1 0.016
response to external biotic stimulus GO:0043207 97 0.016
muscle fiber development GO:0048747 52 0.016
response to topologically incorrect protein GO:0035966 2 0.016
protein import GO:0017038 3 0.016
myotube differentiation GO:0014902 45 0.016
regulation of cytokine production GO:0001817 3 0.016
otic placode formation GO:0043049 23 0.016
negative regulation of developmental process GO:0051093 65 0.016
chondroitin sulfate proteoglycan metabolic process GO:0050654 8 0.016
neuron projection development GO:0031175 180 0.016
Zebrafish
striated muscle tissue development GO:0014706 110 0.016
vasculogenesis GO:0001570 41 0.016
inner ear development GO:0048839 126 0.015
protein localization to nucleus GO:0034504 3 0.015
proximal tubule development GO:0072014 3 0.015
positive regulation of cell communication GO:0010647 56 0.015
positive regulation of blood circulation GO:1903524 2 0.015
cilium organization GO:0044782 71 0.015
phagocytosis GO:0006909 3 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
axon guidance GO:0007411 86 0.015
Zebrafish
behavior GO:0007610 74 0.015
cellular protein metabolic process GO:0044267 129 0.015
Worm
regulation of epithelial to mesenchymal transition GO:0010717 3 0.015
embryonic pattern specification GO:0009880 44 0.015
positive regulation of muscle organ development GO:0048636 1 0.015
phosphate containing compound metabolic process GO:0006796 108 0.015
Worm
facial nerve morphogenesis GO:0021610 1 0.015
macromolecular complex subunit organization GO:0043933 74 0.015
positive regulation of cellular metabolic process GO:0031325 94 0.015
gastrulation GO:0007369 208 0.015
regulation of tissue remodeling GO:0034103 2 0.015
spinal cord development GO:0021510 46 0.015
regulation of cellular protein catabolic process GO:1903362 1 0.015
response to stress GO:0006950 263 0.015
Human
positive regulation of epithelial cell differentiation GO:0030858 2 0.014
periodic partitioning GO:0007365 1 0.014
mesoderm development GO:0007498 88 0.014
response to nutrient GO:0007584 3 0.014
amine metabolic process GO:0009308 2 0.014
axis elongation GO:0003401 31 0.014
regulation of biological quality GO:0065008 263 0.014
cardiac atrium development GO:0003230 4 0.014
central nervous system neuron development GO:0021954 29 0.014
oxoacid metabolic process GO:0043436 31 0.014
anatomical structure arrangement GO:0048532 2 0.014
appendage development GO:0048736 80 0.014
Zebrafish
positive regulation of cell activation GO:0050867 1 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.014
macromolecule localization GO:0033036 54 0.014
nitric oxide biosynthetic process GO:0006809 2 0.013
regulation of bone remodeling GO:0046850 2 0.013
establishment of localization in cell GO:0051649 77 0.013
Worm
golgi vesicle transport GO:0048193 3 0.013
positive regulation of gliogenesis GO:0014015 2 0.013
negative regulation of signaling GO:0023057 96 0.013
positive regulation of dna metabolic process GO:0051054 1 0.013
epidermal cell differentiation GO:0009913 36 0.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.013
generation of neurons GO:0048699 385 0.013
Zebrafish
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
epithelium migration GO:0090132 25 0.013
striated muscle cell development GO:0055002 108 0.013
cytoskeleton organization GO:0007010 96 0.013
regulation of heart contraction GO:0008016 32 0.013
regulation of cell death GO:0010941 103 0.013
negative regulation of smoothened signaling pathway GO:0045879 6 0.013
meiotic cell cycle process GO:1903046 3 0.013
response to uv GO:0009411 3 0.013
tube closure GO:0060606 1 0.013
cell aggregation GO:0098743 3 0.013
morphogenesis of an epithelial fold GO:0060571 1 0.012
cellular component assembly GO:0022607 170 0.012
intracellular signal transduction GO:0035556 85 0.012
cell cycle arrest GO:0007050 1 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
neuron differentiation GO:0030182 353 0.012
Zebrafish
cellular carbohydrate metabolic process GO:0044262 4 0.012
macromolecule modification GO:0043412 111 0.012
Worm
negative regulation of cell communication GO:0010648 96 0.012
neural crest formation GO:0014029 14 0.012
forebrain development GO:0030900 96 0.012
er nucleus signaling pathway GO:0006984 2 0.012
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.012
nuclear envelope organization GO:0006998 2 0.012
negative regulation of chemotaxis GO:0050922 4 0.012
positive regulation of signal transduction GO:0009967 56 0.012
regulation of cell motility GO:2000145 46 0.011
hormone secretion GO:0046879 2 0.011
positive regulation of stem cell proliferation GO:2000648 1 0.011
camera type eye development GO:0043010 222 0.011
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.011
response to chemical GO:0042221 320 0.011
Zebrafish
endoderm formation GO:0001706 29 0.011
mitotic dna integrity checkpoint GO:0044774 4 0.011
superoxide metabolic process GO:0006801 2 0.011
cellular amine metabolic process GO:0044106 2 0.011
sensory organ development GO:0007423 393 0.011
response to unfolded protein GO:0006986 2 0.011
epidermis development GO:0008544 48 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
ear development GO:0043583 127 0.011
negative regulation of multi organism process GO:0043901 3 0.011
regulation of sequestering of calcium ion GO:0051282 4 0.011
localization within membrane GO:0051668 1 0.011
positive regulation of macromolecule metabolic process GO:0010604 93 0.011
trabecula formation GO:0060343 2 0.011
positive regulation of transcription dna templated GO:0045893 57 0.011
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.011
developmental growth GO:0048589 166 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
hatching gland development GO:0048785 3 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
inner ear morphogenesis GO:0042472 63 0.010
pathway restricted smad protein phosphorylation GO:0060389 1 0.010
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.010
regulation of mesenchymal cell proliferation GO:0010464 1 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.010
organelle organization GO:0006996 227 0.010
sympathetic nervous system development GO:0048485 3 0.010
regulation of gtpase activity GO:0043087 2 0.010
cellular amino acid metabolic process GO:0006520 7 0.010
epithelial cell differentiation GO:0030855 116 0.010
otic vesicle development GO:0071599 42 0.010
regulation of dna replication GO:0006275 3 0.010
nucleoside phosphate metabolic process GO:0006753 28 0.010
Worm
phosphorus metabolic process GO:0006793 109 0.010
Worm
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.010
lateral inhibition GO:0046331 1 0.010
mesenchymal cell proliferation GO:0010463 1 0.010
calcium ion transport into cytosol GO:0060402 3 0.010
organophosphate metabolic process GO:0019637 37 0.010
Worm
blood circulation GO:0008015 87 0.010
regulation of cell activation GO:0050865 1 0.010
protein complex localization GO:0031503 1 0.010
chemosensory behavior GO:0007635 1 0.010

plod2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.095
musculoskeletal system disease DOID:17 0 0.032
bone disease DOID:0080001 0 0.026
connective tissue disease DOID:65 0 0.026
nervous system disease DOID:863 0 0.023
sensory system disease DOID:0050155 0 0.020
eye and adnexa disease DOID:1492 0 0.020
eye disease DOID:5614 0 0.020
disease of cellular proliferation DOID:14566 0 0.012