Danio rerio

0 known processes

pmpca

peptidase (mitochondrial processing) alpha

(Aliases: wu:fi19e06,zgc:101647,wu:fj83d11)

pmpca biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.132
single organism organelle organization GO:1902589 199 0.088
mitochondrion organization GO:0007005 4 0.079
aging GO:0007568 2 0.079
regulation of macromolecule metabolic process GO:0060255 317 0.070
mitochondrial transport GO:0006839 2 0.061
response to stress GO:0006950 263 0.061
establishment of localization GO:0051234 244 0.060
aromatic compound biosynthetic process GO:0019438 217 0.057
sulfur compound biosynthetic process GO:0044272 9 0.056
nuclear transport GO:0051169 4 0.047
multicellular organism growth GO:0035264 4 0.046
regulation of metabolic process GO:0019222 359 0.046
establishment of protein localization to organelle GO:0072594 4 0.045
meiotic nuclear division GO:0007126 4 0.044
cellular nitrogen compound metabolic process GO:0034641 290 0.043
embryo development ending in birth or egg hatching GO:0009792 271 0.043
coenzyme biosynthetic process GO:0009108 2 0.042
maintenance of location GO:0051235 4 0.040
organelle organization GO:0006996 227 0.040
mitochondrion morphogenesis GO:0070584 2 0.040
regulation of biological quality GO:0065008 263 0.038
transport GO:0006810 220 0.038
cellular macromolecule metabolic process GO:0044260 391 0.038
gene expression GO:0010467 252 0.037
small molecule metabolic process GO:0044281 77 0.036
zymogen activation GO:0031638 3 0.035
organic substance biosynthetic process GO:1901576 289 0.035
regulation of response to stimulus GO:0048583 269 0.033
heterocycle biosynthetic process GO:0018130 215 0.032
negative regulation of biological process GO:0048519 304 0.032
response to chemical GO:0042221 320 0.031
protein modification process GO:0036211 100 0.031
response to organic substance GO:0010033 153 0.031
nuclear export GO:0051168 1 0.031
lipid storage GO:0019915 1 0.031
protein localization to nucleus GO:0034504 3 0.031
carbohydrate derivative biosynthetic process GO:1901137 43 0.031
negative regulation of kinase activity GO:0033673 4 0.031
positive regulation of transport GO:0051050 2 0.030
regulation of gene expression GO:0010468 265 0.030
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.030
regulation of multicellular organism growth GO:0040014 4 0.030
cellular component movement GO:0006928 335 0.030
intracellular steroid hormone receptor signaling pathway GO:0030518 5 0.030
single organism transport GO:0044765 206 0.030
single organism localization GO:1902578 225 0.030
single organism nuclear import GO:1902593 3 0.029
protein import GO:0017038 3 0.029
nucleocytoplasmic transport GO:0006913 4 0.029
locomotion GO:0040011 313 0.028
intracellular estrogen receptor signaling pathway GO:0030520 3 0.028
positive regulation of cellular process GO:0048522 201 0.027
nucleoside monophosphate catabolic process GO:0009125 4 0.027
endoplasmic reticulum unfolded protein response GO:0030968 2 0.027
nuclear import GO:0051170 3 0.027
cellular biosynthetic process GO:0044249 286 0.026
negative regulation of defense response GO:0031348 2 0.026
sister chromatid cohesion GO:0007062 2 0.025
regulation of primary metabolic process GO:0080090 311 0.025
cellular response to oxygen levels GO:0071453 1 0.025
nucleoside phosphate biosynthetic process GO:1901293 21 0.025
biosynthetic process GO:0009058 294 0.025
negative regulation of protein kinase activity GO:0006469 4 0.025
regulation of signaling GO:0023051 235 0.024
negative regulation of protein phosphorylation GO:0001933 4 0.024
cellular ketone metabolic process GO:0042180 11 0.024
signal transduction GO:0007165 455 0.024
regulation of signal transduction GO:0009966 225 0.024
organic cyclic compound biosynthetic process GO:1901362 223 0.024
positive regulation of cellular component biogenesis GO:0044089 3 0.023
rna biosynthetic process GO:0032774 181 0.023
protein import into nucleus GO:0006606 3 0.023
regulation of cellular metabolic process GO:0031323 320 0.023
regulation of cellular biosynthetic process GO:0031326 245 0.023
macromolecule modification GO:0043412 111 0.022
regulation of cytoplasmic transport GO:1903649 4 0.022
nucleotide biosynthetic process GO:0009165 21 0.022
protein complex localization GO:0031503 1 0.022
amine metabolic process GO:0009308 2 0.022
cellular respiration GO:0045333 3 0.022
sensory organ development GO:0007423 393 0.022
er nucleus signaling pathway GO:0006984 2 0.022
nucleobase containing compound biosynthetic process GO:0034654 205 0.022
response to uv GO:0009411 3 0.022
single organism metabolic process GO:0044710 217 0.022
cell migration GO:0016477 237 0.021
cell part morphogenesis GO:0032990 246 0.021
neurotransmitter transport GO:0006836 2 0.021
regulation of tube size GO:0035150 2 0.021
regulation of blood vessel size GO:0050880 2 0.021
negative regulation of cell communication GO:0010648 96 0.020
meiotic cell cycle process GO:1903046 3 0.020
lymphocyte proliferation GO:0046651 1 0.020
response to unfolded protein GO:0006986 2 0.020
regulation of nucleoside metabolic process GO:0009118 2 0.020
tissue remodeling GO:0048771 4 0.020
dna catabolic process GO:0006308 1 0.020
multi organism process GO:0051704 134 0.020
nucleic acid metabolic process GO:0090304 244 0.020
mononuclear cell proliferation GO:0032943 1 0.020
phosphorus metabolic process GO:0006793 109 0.020
b cell differentiation GO:0030183 1 0.020
regulation of cytokine production GO:0001817 3 0.020
protein metabolic process GO:0019538 183 0.019
regulation of nucleocytoplasmic transport GO:0046822 2 0.019
positive regulation of biological process GO:0048518 253 0.019
phosphate containing compound metabolic process GO:0006796 108 0.019
regulation of intracellular protein transport GO:0033157 3 0.019
cell morphogenesis GO:0000902 289 0.019
regulation of establishment of protein localization GO:0070201 4 0.019
cellular protein metabolic process GO:0044267 129 0.019
protein targeting to nucleus GO:0044744 3 0.019
regulation of cell projection assembly GO:0060491 4 0.019
organonitrogen compound metabolic process GO:1901564 74 0.018
negative regulation of cellular process GO:0048523 283 0.018
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.018
growth GO:0040007 174 0.018
cell aging GO:0007569 2 0.018
nucleobase containing compound metabolic process GO:0006139 274 0.018
system process GO:0003008 185 0.018
eye development GO:0001654 277 0.018
oxoacid metabolic process GO:0043436 31 0.017
regulation of stem cell differentiation GO:2000736 4 0.017
morphogenesis of an epithelium GO:0002009 333 0.017
cellular component disassembly GO:0022411 1 0.017
negative regulation of signaling GO:0023057 96 0.017
organic acid metabolic process GO:0006082 31 0.017
negative regulation of mapk cascade GO:0043409 4 0.017
macromolecule biosynthetic process GO:0009059 227 0.017
negative regulation of catabolic process GO:0009895 3 0.017
regulation of multicellular organismal process GO:0051239 277 0.017
transcription dna templated GO:0006351 181 0.017
cellular component assembly involved in morphogenesis GO:0010927 107 0.017
secondary metabolic process GO:0019748 3 0.017
stem cell proliferation GO:0072089 4 0.017
guanosine containing compound catabolic process GO:1901069 2 0.017
regulation of cellular amine metabolic process GO:0033238 0 0.016
mesenchymal cell development GO:0014031 78 0.016
cellular response to unfolded protein GO:0034620 2 0.016
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 10 0.016
cellular protein modification process GO:0006464 100 0.016
localization of cell GO:0051674 244 0.016
somatic cell dna recombination GO:0016444 1 0.016
regulation of reproductive process GO:2000241 4 0.016
lipid catabolic process GO:0016042 4 0.016
microtubule organizing center organization GO:0031023 1 0.016
cellular amine metabolic process GO:0044106 2 0.016
regulation of myotube differentiation GO:0010830 2 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.016
leukocyte proliferation GO:0070661 1 0.016
regulation of neurotransmitter transport GO:0051588 1 0.016
cellular response to topologically incorrect protein GO:0035967 2 0.016
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.016
cellular response to decreased oxygen levels GO:0036294 1 0.016
regulation of microtubule cytoskeleton organization GO:0070507 3 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
single organism cellular localization GO:1902580 46 0.015
digestive system development GO:0055123 289 0.015
cell motility GO:0048870 244 0.015
regulation of inflammatory response GO:0050727 2 0.015
muscle cell migration GO:0014812 4 0.015
cellular response to chemical stimulus GO:0070887 157 0.015
phagocytosis GO:0006909 3 0.015
regulation of neural precursor cell proliferation GO:2000177 3 0.015
regulation of collateral sprouting in absence of injury GO:0048696 4 0.015
cellular response to hypoxia GO:0071456 1 0.015
positive regulation of cytoskeleton organization GO:0051495 3 0.015
rna metabolic process GO:0016070 219 0.015
regulation of protein transport GO:0051223 3 0.015
cell projection organization GO:0030030 284 0.015
heart development GO:0007507 313 0.015
nitrogen compound metabolic process GO:0006807 319 0.015
cell substrate adhesion GO:0031589 4 0.015
positive regulation of catabolic process GO:0009896 4 0.015
embryonic organ development GO:0048568 381 0.014
synaptic growth at neuromuscular junction GO:0051124 2 0.014
cell growth GO:0016049 57 0.014
cellular component biogenesis GO:0044085 178 0.014
regulation of protein catabolic process GO:0042176 1 0.014
regulation of cell activation GO:0050865 1 0.014
single organism biosynthetic process GO:0044711 71 0.014
neurotransmitter secretion GO:0007269 2 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
b cell activation GO:0042113 2 0.014
circulatory system process GO:0003013 87 0.014
b cell mediated immunity GO:0019724 3 0.014
regulation of protein ubiquitination GO:0031396 3 0.014
positive regulation of metabolic process GO:0009893 108 0.014
cellular amino acid metabolic process GO:0006520 7 0.014
mesenchymal cell differentiation GO:0048762 87 0.014
adult behavior GO:0030534 2 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
cell cycle GO:0007049 93 0.014
dicarboxylic acid metabolic process GO:0043648 1 0.013
organic cyclic compound metabolic process GO:1901360 301 0.013
regulation of cell communication GO:0010646 232 0.013
regulation of apoptotic process GO:0042981 98 0.013
regulation of jun kinase activity GO:0043506 3 0.013
determination of bilateral symmetry GO:0009855 204 0.013
neuroblast proliferation GO:0007405 2 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
rna export from nucleus GO:0006405 1 0.013
immune system process GO:0002376 241 0.013
cytoskeleton organization GO:0007010 96 0.013
regulation of synapse organization GO:0050807 3 0.013
neural crest cell differentiation GO:0014033 72 0.013
amino acid transport GO:0006865 2 0.013
embryonic heart tube development GO:0035050 133 0.013
thioester biosynthetic process GO:0035384 1 0.013
renal tubule morphogenesis GO:0061333 1 0.013
negative regulation of cellular metabolic process GO:0031324 77 0.013
regulation of transporter activity GO:0032409 2 0.013
regulation of peptidase activity GO:0052547 23 0.013
protein complex disassembly GO:0043241 1 0.013
regulation of blood pressure GO:0008217 1 0.013
immunoglobulin mediated immune response GO:0016064 3 0.013
regulation of gtpase activity GO:0043087 2 0.013
specification of symmetry GO:0009799 204 0.013
acyl coa metabolic process GO:0006637 1 0.013
negative regulation of response to stimulus GO:0048585 104 0.013
ribonucleoside biosynthetic process GO:0042455 2 0.013
odontogenesis of dentin containing tooth GO:0042475 1 0.012
mesenchyme development GO:0060485 127 0.012
embryonic organ morphogenesis GO:0048562 274 0.012
camera type eye development GO:0043010 222 0.012
cellular component morphogenesis GO:0032989 336 0.012
regulation of protein targeting GO:1903533 2 0.012
digestive tract development GO:0048565 265 0.012
protein polymerization GO:0051258 4 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.012
positive regulation of cell activation GO:0050867 1 0.012
purine nucleoside monophosphate catabolic process GO:0009128 4 0.012
generation of neurons GO:0048699 385 0.012
lateral line development GO:0048882 66 0.012
acetyl coa metabolic process GO:0006084 1 0.012
peptide transport GO:0015833 1 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
response to wounding GO:0009611 116 0.012
response to amino acid GO:0043200 2 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.012
organic substance transport GO:0071702 58 0.012
establishment of localization in cell GO:0051649 77 0.012
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
cognition GO:0050890 1 0.012
epithelial tube morphogenesis GO:0060562 148 0.012
organonitrogen compound biosynthetic process GO:1901566 47 0.012
positive regulation of epithelial cell proliferation GO:0050679 1 0.012
actin polymerization or depolymerization GO:0008154 2 0.012
oxidative phosphorylation GO:0006119 1 0.012
actin filament based movement GO:0030048 1 0.012
oocyte maturation GO:0001556 4 0.012
negative regulation of metabolic process GO:0009892 86 0.012
intra s dna damage checkpoint GO:0031573 1 0.012
heterocycle metabolic process GO:0046483 290 0.012
neuron projection morphogenesis GO:0048812 161 0.012
hormone transport GO:0009914 2 0.011
regulation of developmental process GO:0050793 247 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
protein stabilization GO:0050821 2 0.011
sensory system development GO:0048880 76 0.011
transmembrane transport GO:0055085 120 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
central nervous system development GO:0007417 387 0.011
inositol lipid mediated signaling GO:0048017 2 0.011
regulation of skeletal muscle fiber development GO:0048742 2 0.011
microtubule based process GO:0007017 60 0.011
regulation of nucleic acid templated transcription GO:1903506 213 0.011
organic acid catabolic process GO:0016054 3 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
pyrimidine containing compound metabolic process GO:0072527 3 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
retina development in camera type eye GO:0060041 146 0.011
cellular response to organic substance GO:0071310 105 0.011
establishment of organelle localization GO:0051656 45 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
cellular macromolecule biosynthetic process GO:0034645 224 0.011
regulation of biosynthetic process GO:0009889 250 0.011
regulation of protein complex assembly GO:0043254 3 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
regulation of cellular component organization GO:0051128 86 0.011
chordate embryonic development GO:0043009 271 0.011
cellular response to retinoic acid GO:0071300 1 0.011
positive regulation of muscle organ development GO:0048636 1 0.011
cell death GO:0008219 121 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
determination of left right symmetry GO:0007368 179 0.011
cellular response to radiation GO:0071478 4 0.011
g2 dna damage checkpoint GO:0031572 3 0.011
sensory perception of pain GO:0019233 1 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
phosphatidylinositol mediated signaling GO:0048015 2 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
cellular component assembly GO:0022607 170 0.011
response to nutrient GO:0007584 3 0.011
catechol containing compound metabolic process GO:0009712 2 0.011
macromolecular complex subunit organization GO:0043933 74 0.011
cellular aromatic compound metabolic process GO:0006725 295 0.011
oxidoreduction coenzyme metabolic process GO:0006733 1 0.011
calcium mediated signaling GO:0019722 2 0.011
behavior GO:0007610 74 0.010
axon development GO:0061564 166 0.010
type i interferon production GO:0032606 2 0.010
macromolecular complex disassembly GO:0032984 1 0.010
hormone secretion GO:0046879 2 0.010
regulation of neurotransmitter secretion GO:0046928 1 0.010
regulation of systemic arterial blood pressure GO:0003073 1 0.010
neural crest cell development GO:0014032 62 0.010
regulation of oligodendrocyte differentiation GO:0048713 1 0.010
positive regulation of immune effector process GO:0002699 3 0.010
regulation of macromolecule biosynthetic process GO:0010556 225 0.010
establishment of synaptic vesicle localization GO:0097480 1 0.010
synaptic vesicle localization GO:0097479 1 0.010
protein homooligomerization GO:0051260 3 0.010
response to other organism GO:0051707 97 0.010
regulation of protein polymerization GO:0032271 2 0.010

pmpca disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.075
sensory system disease DOID:0050155 0 0.070
eye and adnexa disease DOID:1492 0 0.070
nervous system disease DOID:863 0 0.070
eye disease DOID:5614 0 0.070
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
disease of metabolism DOID:0014667 0 0.018
inherited metabolic disorder DOID:655 0 0.015
organ system cancer DOID:0050686 0 0.015
musculoskeletal system disease DOID:17 0 0.014
retinal disease DOID:5679 0 0.012
retinal degeneration DOID:8466 0 0.012