Danio rerio

19 known processes

pnn

pinin, desmosome associated protein

(Aliases: wu:fb24d03)

pnn biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
alternative mrna splicing via spliceosome GO:0000380 1 0.546
cellular macromolecule metabolic process GO:0044260 391 0.134
immune system process GO:0002376 241 0.132
positive regulation of cellular component biogenesis GO:0044089 3 0.115
larval development GO:0002164 2 0.111
regulation of mrna splicing via spliceosome GO:0048024 3 0.103
negative regulation of gene expression GO:0010629 65 0.099
regulation of mrna processing GO:0050684 3 0.087
embryo development ending in birth or egg hatching GO:0009792 271 0.085
regulation of rna metabolic process GO:0051252 224 0.079
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.076
regulation of cellular metabolic process GO:0031323 320 0.075
stem cell maintenance GO:0019827 4 0.073
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.069
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.067
gene expression GO:0010467 252 0.065
regulation of nitrogen compound metabolic process GO:0051171 251 0.065
meiotic nuclear division GO:0007126 4 0.065
heterocycle biosynthetic process GO:0018130 215 0.063
organic cyclic compound biosynthetic process GO:1901362 223 0.063
cellular protein catabolic process GO:0044257 4 0.059
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 10 0.059
regulation of gene expression GO:0010468 265 0.058
protein metabolic process GO:0019538 183 0.057
rna biosynthetic process GO:0032774 181 0.057
cellular aromatic compound metabolic process GO:0006725 295 0.056
regulation of primary metabolic process GO:0080090 311 0.055
organic cyclic compound metabolic process GO:1901360 301 0.054
cellular macromolecule biosynthetic process GO:0034645 224 0.052
regulation of cellular biosynthetic process GO:0031326 245 0.052
adult behavior GO:0030534 2 0.051
aging GO:0007568 2 0.048
multicellular organism growth GO:0035264 4 0.046
regulation of meiotic cell cycle GO:0051445 1 0.045
maintenance of location GO:0051235 4 0.045
nucleic acid metabolic process GO:0090304 244 0.044
regulation of mrna metabolic process GO:1903311 6 0.043
hematopoietic or lymphoid organ development GO:0048534 191 0.043
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.042
ubiquitin dependent protein catabolic process GO:0006511 3 0.041
embryonic organ morphogenesis GO:0048562 274 0.039
transcription from rna polymerase ii promoter GO:0006366 80 0.039
regulation of rna splicing GO:0043484 8 0.039
organic substance biosynthetic process GO:1901576 289 0.038
synaptic growth at neuromuscular junction GO:0051124 2 0.038
establishment of protein localization to organelle GO:0072594 4 0.037
nucleobase containing compound metabolic process GO:0006139 274 0.037
macromolecule biosynthetic process GO:0009059 227 0.037
cellular nitrogen compound biosynthetic process GO:0044271 218 0.036
rna metabolic process GO:0016070 219 0.035
stem cell development GO:0048864 82 0.035
chordate embryonic development GO:0043009 271 0.034
negative regulation of ras protein signal transduction GO:0046580 1 0.034
negative regulation of metabolic process GO:0009892 86 0.034
positive regulation of cell cycle GO:0045787 3 0.034
immune system development GO:0002520 191 0.033
response to drug GO:0042493 3 0.033
cellular biosynthetic process GO:0044249 286 0.033
regulation of developmental process GO:0050793 247 0.031
regulation of macromolecule metabolic process GO:0060255 317 0.031
regulation of transcription dna templated GO:0006355 213 0.031
rna splicing via transesterification reactions GO:0000375 10 0.030
negative regulation of cellular process GO:0048523 283 0.030
rna splicing GO:0008380 16 0.030
skeletal system development GO:0001501 181 0.029
transport GO:0006810 220 0.029
macromolecule methylation GO:0043414 19 0.029
regulation of multicellular organism growth GO:0040014 4 0.029
negative regulation of macromolecule metabolic process GO:0010605 76 0.029
locomotion GO:0040011 313 0.028
striated muscle cell differentiation GO:0051146 129 0.028
cellular protein metabolic process GO:0044267 129 0.028
central nervous system neuron differentiation GO:0021953 74 0.028
regulation of biological quality GO:0065008 263 0.028
spliceosomal complex assembly GO:0000245 1 0.027
heterocycle metabolic process GO:0046483 290 0.027
positive regulation of chromatin modification GO:1903310 1 0.027
protein import GO:0017038 3 0.027
transcription dna templated GO:0006351 181 0.027
nuclear import GO:0051170 3 0.027
stem cell proliferation GO:0072089 4 0.026
carboxylic acid metabolic process GO:0019752 22 0.026
cellular component morphogenesis GO:0032989 336 0.026
proteasomal protein catabolic process GO:0010498 2 0.026
regulation of metabolic process GO:0019222 359 0.026
regulation of rna biosynthetic process GO:2001141 213 0.025
regulation of histone methylation GO:0031060 3 0.025
positive regulation of biological process GO:0048518 253 0.025
positive regulation of synapse assembly GO:0051965 1 0.024
negative regulation of biological process GO:0048519 304 0.024
histone h4 k20 methylation GO:0034770 2 0.024
aromatic compound biosynthetic process GO:0019438 217 0.024
protein targeting to nucleus GO:0044744 3 0.024
heart development GO:0007507 313 0.023
somitogenesis GO:0001756 87 0.023
modification dependent macromolecule catabolic process GO:0043632 3 0.023
positive regulation of histone modification GO:0031058 1 0.023
regulation of synapse organization GO:0050807 3 0.023
negative regulation of catabolic process GO:0009895 3 0.023
signal transduction GO:0007165 455 0.023
regulation of protein catabolic process GO:0042176 1 0.023
generation of neurons GO:0048699 385 0.022
regulation of synapse assembly GO:0051963 3 0.022
positive regulation of chromosome organization GO:2001252 1 0.022
negative regulation of cellular metabolic process GO:0031324 77 0.022
hemopoiesis GO:0030097 183 0.022
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.022
nucleocytoplasmic transport GO:0006913 4 0.022
programmed cell death GO:0012501 119 0.022
regulation of nucleic acid templated transcription GO:1903506 213 0.021
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.021
stem cell differentiation GO:0048863 117 0.021
regulation of cell death GO:0010941 103 0.021
protein stabilization GO:0050821 2 0.020
positive regulation of dna metabolic process GO:0051054 1 0.020
nucleobase containing compound biosynthetic process GO:0034654 205 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.020
biosynthetic process GO:0009058 294 0.019
rna processing GO:0006396 25 0.019
modification of morphology or physiology of other organism GO:0035821 4 0.019
regulation of mrna catabolic process GO:0061013 3 0.019
neuron development GO:0048666 262 0.019
regulation of intracellular protein transport GO:0033157 3 0.019
hematopoietic stem cell differentiation GO:0060218 20 0.019
transcription from rna polymerase iii promoter GO:0006383 1 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.019
compound eye development GO:0048749 2 0.019
erythrocyte maturation GO:0043249 8 0.019
cellular nitrogen compound metabolic process GO:0034641 290 0.019
dorsal ventral pattern formation GO:0009953 125 0.018
b cell mediated immunity GO:0019724 3 0.018
protein acylation GO:0043543 3 0.018
macromolecule localization GO:0033036 54 0.018
nitrogen compound metabolic process GO:0006807 319 0.018
response to chemical GO:0042221 320 0.018
positive regulation of transport GO:0051050 2 0.018
histone h3 k4 methylation GO:0051568 2 0.018
growth GO:0040007 174 0.018
nuclear transport GO:0051169 4 0.018
localization of cell GO:0051674 244 0.018
cellular component assembly GO:0022607 170 0.018
protein import into nucleus GO:0006606 3 0.018
modification dependent protein catabolic process GO:0019941 3 0.017
lipid storage GO:0019915 1 0.017
regulation of macromolecule biosynthetic process GO:0010556 225 0.017
positive regulation of rna metabolic process GO:0051254 59 0.017
head development GO:0060322 303 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
somite development GO:0061053 96 0.017
hepaticobiliary system development GO:0061008 98 0.017
posterior lateral line system development GO:0048915 46 0.017
negative regulation of dna templated transcription elongation GO:0032785 1 0.017
amine metabolic process GO:0009308 2 0.017
cell morphogenesis GO:0000902 289 0.016
negative regulation of defense response GO:0031348 2 0.016
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
positive regulation of developmental process GO:0051094 50 0.016
intracellular estrogen receptor signaling pathway GO:0030520 3 0.016
cellular component biogenesis GO:0044085 178 0.016
negative regulation of rna splicing GO:0033119 1 0.016
rna export from nucleus GO:0006405 1 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.016
primary neural tube formation GO:0014020 1 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.016
regulation of response to stimulus GO:0048583 269 0.016
rna transport GO:0050658 2 0.016
myeloid cell differentiation GO:0030099 86 0.015
regulation of gene expression epigenetic GO:0040029 11 0.015
myeloid cell homeostasis GO:0002262 56 0.015
positive regulation of metabolic process GO:0009893 108 0.015
determination of bilateral symmetry GO:0009855 204 0.015
digestive tract development GO:0048565 265 0.015
embryonic skeletal joint morphogenesis GO:0060272 3 0.015
positive regulation of rna biosynthetic process GO:1902680 57 0.015
epithelial cell differentiation GO:0030855 116 0.015
peptidyl lysine monomethylation GO:0018026 1 0.015
embryonic skeletal system development GO:0048706 97 0.015
regulation of establishment of protein localization GO:0070201 4 0.015
neuron differentiation GO:0030182 353 0.014
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.014
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.014
erythrocyte homeostasis GO:0034101 55 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.014
mesenchymal cell differentiation GO:0048762 87 0.014
positive regulation of gliogenesis GO:0014015 2 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.014
peptidyl lysine methylation GO:0018022 3 0.014
negative regulation of histone modification GO:0031057 1 0.014
regulation of response to cytokine stimulus GO:0060759 3 0.014
embryonic heart tube development GO:0035050 133 0.014
adherens junction organization GO:0034332 4 0.014
negative regulation of chromosome organization GO:2001251 1 0.014
dna biosynthetic process GO:0071897 3 0.014
positive regulation of cellular catabolic process GO:0031331 3 0.014
regulation of stem cell differentiation GO:2000736 4 0.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.013
regulation of histone h3 k9 methylation GO:0051570 2 0.013
regulation of glial cell differentiation GO:0045685 4 0.013
single organism nuclear import GO:1902593 3 0.013
regulation of nucleocytoplasmic transport GO:0046822 2 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
positive regulation of catabolic process GO:0009896 4 0.013
cell projection organization GO:0030030 284 0.013
negative regulation of dna metabolic process GO:0051053 4 0.013
embryonic cranial skeleton morphogenesis GO:0048701 90 0.013
cell death GO:0008219 121 0.013
negative regulation of dna replication GO:0008156 2 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.013
sex determination GO:0007530 1 0.013
phagocytosis GO:0006909 3 0.013
sensory organ development GO:0007423 393 0.013
peptidyl lysine acetylation GO:0018394 2 0.013
heart morphogenesis GO:0003007 156 0.013
regionalization GO:0003002 274 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
regulation of dna templated transcription elongation GO:0032784 3 0.012
cellular response to external stimulus GO:0071496 2 0.012
oxoacid metabolic process GO:0043436 31 0.012
determination of heart left right asymmetry GO:0061371 117 0.012
negative regulation of biosynthetic process GO:0009890 55 0.012
homeostasis of number of cells GO:0048872 62 0.012
nucleic acid templated transcription GO:0097659 181 0.012
response to hexose GO:0009746 3 0.012
regulation of cytokine mediated signaling pathway GO:0001959 3 0.012
skeletal system morphogenesis GO:0048705 102 0.012
mitotic cell cycle embryonic GO:0045448 2 0.012
regulation of cell activation GO:0050865 1 0.012
protein acetylation GO:0006473 2 0.012
response to corticosteroid GO:0031960 1 0.012
protein polyubiquitination GO:0000209 4 0.012
cilium morphogenesis GO:0060271 85 0.012
single organism organelle organization GO:1902589 199 0.012
interspecies interaction between organisms GO:0044419 4 0.012
central nervous system development GO:0007417 387 0.012
germ line stem cell maintenance GO:0030718 2 0.011
regulation of protein complex assembly GO:0043254 3 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.011
regulation of skeletal muscle tissue development GO:0048641 4 0.011
regulation of microtubule cytoskeleton organization GO:0070507 3 0.011
mesenchyme development GO:0060485 127 0.011
rna localization GO:0006403 4 0.011
regulation of multicellular organismal development GO:2000026 223 0.011
viral process GO:0016032 1 0.011
positive regulation of carbohydrate metabolic process GO:0045913 1 0.011
positive regulation of dna templated transcription elongation GO:0032786 1 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
specification of symmetry GO:0009799 204 0.011
muscle tissue development GO:0060537 110 0.011
b cell activation GO:0042113 2 0.011
nucleic acid transport GO:0050657 2 0.011
pharyngeal muscle development GO:0043282 4 0.011
small gtpase mediated signal transduction GO:0007264 8 0.011
embryonic skeletal system morphogenesis GO:0048704 93 0.011
cellular amine metabolic process GO:0044106 2 0.011
neuronal stem cell maintenance GO:0097150 2 0.011
mesenchymal cell development GO:0014031 78 0.011
establishment of rna localization GO:0051236 3 0.011
positive regulation of mrna metabolic process GO:1903313 2 0.011
anterior posterior pattern specification GO:0009952 152 0.011
ras protein signal transduction GO:0007265 7 0.011
cellular protein modification process GO:0006464 100 0.011
cell cycle GO:0007049 93 0.011
posterior lateral line development GO:0048916 38 0.011
nuclear migration GO:0007097 3 0.011
dna templated transcription elongation GO:0006354 3 0.011
cell motility GO:0048870 244 0.011
gland development GO:0048732 143 0.011
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.010
death GO:0016265 121 0.010
regulation of epidermis development GO:0045682 2 0.010
positive regulation of macromolecule metabolic process GO:0010604 93 0.010
hematopoietic progenitor cell differentiation GO:0002244 23 0.010
cellular component disassembly GO:0022411 1 0.010
regulation of multicellular organismal process GO:0051239 277 0.010
neuroblast proliferation GO:0007405 2 0.010
negative regulation of multi organism process GO:0043901 3 0.010
regulation of growth rate GO:0040009 1 0.010
mrna metabolic process GO:0016071 20 0.010
regulation of programmed cell death GO:0043067 101 0.010

pnn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
motor neuron disease DOID:231 0 0.025
neurodegenerative disease DOID:1289 0 0.025
nervous system disease DOID:863 0 0.025
amyotrophic lateral sclerosis DOID:332 0 0.025
central nervous system disease DOID:331 0 0.025
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011