Danio rerio

0 known processes

pnp4a

purine nucleoside phosphorylase 4a

(Aliases: zgc:86889)

pnp4a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleobase containing compound biosynthetic process GO:0034654 205 0.589
Mouse
xanthophore differentiation GO:0050936 3 0.453
cellular biosynthetic process GO:0044249 286 0.406
Mouse
pigmentation GO:0043473 85 0.292
regulation of retina development in camera type eye GO:1902866 2 0.274
cellular nitrogen compound biosynthetic process GO:0044271 218 0.268
Mouse
pigment cell differentiation GO:0050931 38 0.262
nucleobase containing compound metabolic process GO:0006139 274 0.256
Mouse
leukocyte proliferation GO:0070661 1 0.230
Mouse
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 1 0.207
dopamine metabolic process GO:0042417 2 0.193
dopamine biosynthetic process GO:0042416 2 0.184
melanocyte differentiation GO:0030318 26 0.166
developmental pigmentation GO:0048066 48 0.159
embryonic organ morphogenesis GO:0048562 274 0.157
catechol containing compound metabolic process GO:0009712 2 0.137
regulation of neural retina development GO:0061074 2 0.136
tube morphogenesis GO:0035239 349 0.119
response to chemical GO:0042221 320 0.111
camera type eye development GO:0043010 222 0.111
regulation of developmental pigmentation GO:0048070 6 0.109
mesenchymal cell development GO:0014031 78 0.109
cellular component morphogenesis GO:0032989 336 0.105
heterocycle biosynthetic process GO:0018130 215 0.104
Mouse
mesenchymal cell differentiation GO:0048762 87 0.100
regulation of histone methylation GO:0031060 3 0.100
maintenance of location GO:0051235 4 0.098
generation of neurons GO:0048699 385 0.090
cellular nitrogen compound metabolic process GO:0034641 290 0.090
Mouse
embryonic organ development GO:0048568 381 0.087
nitrogen compound metabolic process GO:0006807 319 0.084
Mouse
cell cell junction maintenance GO:0045217 1 0.083
organic cyclic compound metabolic process GO:1901360 301 0.080
Mouse
mesenchyme development GO:0060485 127 0.079
negative regulation of programmed cell death GO:0043069 58 0.079
Mouse
cellular amine metabolic process GO:0044106 2 0.073
regulation of synaptic plasticity GO:0048167 1 0.069
pigment granule organization GO:0048753 4 0.067
skeletal system development GO:0001501 181 0.067
cellular component movement GO:0006928 335 0.065
chordate embryonic development GO:0043009 271 0.065
aging GO:0007568 2 0.065
digestive system development GO:0055123 289 0.063
positive regulation of biological process GO:0048518 253 0.061
Mouse
central nervous system neuron differentiation GO:0021953 74 0.060
catecholamine metabolic process GO:0006584 2 0.056
positive regulation of chromosome organization GO:2001252 1 0.055
sensory organ development GO:0007423 393 0.054
cellular macromolecule metabolic process GO:0044260 391 0.054
Mouse
regulation of cell differentiation GO:0045595 142 0.053
Mouse
embryonic skeletal system development GO:0048706 97 0.053
spinal cord development GO:0021510 46 0.051
neuroepithelial cell differentiation GO:0060563 26 0.051
catechol containing compound biosynthetic process GO:0009713 2 0.051
organic substance biosynthetic process GO:1901576 289 0.051
Mouse
aromatic compound biosynthetic process GO:0019438 217 0.050
Mouse
neuron differentiation GO:0030182 353 0.050
regulation of response to stimulus GO:0048583 269 0.050
Mouse
positive regulation of myeloid cell differentiation GO:0045639 2 0.050
melanocyte migration GO:0097324 4 0.049
rna biosynthetic process GO:0032774 181 0.048
periodic partitioning GO:0007365 1 0.047
rna metabolic process GO:0016070 219 0.046
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.045
macrophage chemotaxis GO:0048246 3 0.045
biosynthetic process GO:0009058 294 0.045
Mouse
eye development GO:0001654 277 0.045
positive regulation of histone modification GO:0031058 1 0.044
nuclear import GO:0051170 3 0.043
single organism metabolic process GO:0044710 217 0.041
Mouse
small molecule metabolic process GO:0044281 77 0.040
Mouse
brain development GO:0007420 293 0.040
positive regulation of macrophage chemotaxis GO:0010759 1 0.039
central nervous system development GO:0007417 387 0.039
catecholamine biosynthetic process GO:0042423 2 0.039
regulation of nitrogen compound metabolic process GO:0051171 251 0.038
Mouse
phenol containing compound biosynthetic process GO:0046189 4 0.036
digestive tract development GO:0048565 265 0.036
aromatic amino acid family metabolic process GO:0009072 1 0.035
cell differentiation in spinal cord GO:0021515 40 0.035
signal transduction GO:0007165 455 0.035
Mouse
organonitrogen compound metabolic process GO:1901564 74 0.034
Mouse
larval development GO:0002164 2 0.034
phosphate containing compound metabolic process GO:0006796 108 0.033
Mouse
cell morphogenesis GO:0000902 289 0.031
programmed cell death GO:0012501 119 0.031
Mouse
regulation of rna metabolic process GO:0051252 224 0.031
transcription dna templated GO:0006351 181 0.031
negative regulation of apoptotic process GO:0043066 55 0.030
Mouse
osteoclast development GO:0036035 1 0.030
cell proliferation GO:0008283 80 0.029
Mouse
spermatid differentiation GO:0048515 2 0.029
enzyme linked receptor protein signaling pathway GO:0007167 106 0.029
cellular aromatic compound metabolic process GO:0006725 295 0.029
Mouse
extrinsic apoptotic signaling pathway GO:0097191 3 0.028
response to organic substance GO:0010033 153 0.027
melanosome organization GO:0032438 4 0.027
embryonic skeletal system morphogenesis GO:0048704 93 0.026
regulation of programmed cell death GO:0043067 101 0.026
Mouse
organonitrogen compound biosynthetic process GO:1901566 47 0.026
Mouse
carboxylic acid metabolic process GO:0019752 22 0.025
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.025
organic cyclic compound biosynthetic process GO:1901362 223 0.025
Mouse
single organism biosynthetic process GO:0044711 71 0.025
Mouse
positive regulation of chromatin modification GO:1903310 1 0.024
regulation of transcription dna templated GO:0006355 213 0.024
segment polarity determination GO:0007367 1 0.024
cell death GO:0008219 121 0.024
Mouse
retina development in camera type eye GO:0060041 146 0.024
neural crest cell differentiation GO:0014033 72 0.024
regulation of multicellular organismal development GO:2000026 223 0.023
Mouse
microglia differentiation GO:0014004 1 0.023
regulation of developmental process GO:0050793 247 0.023
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.023
regulation of cell death GO:0010941 103 0.023
Mouse
positive regulation of retina development in camera type eye GO:1902868 1 0.023
stem cell differentiation GO:0048863 117 0.023
anterior posterior pattern specification GO:0009952 152 0.023
regulation of macromolecule biosynthetic process GO:0010556 225 0.022
regulation of anatomical structure morphogenesis GO:0022603 130 0.022
cell motility GO:0048870 244 0.022
cation transport GO:0006812 81 0.022
neuron development GO:0048666 262 0.020
cellular macromolecule biosynthetic process GO:0034645 224 0.020
mononuclear cell migration GO:0071674 1 0.020
regulation of gene expression GO:0010468 265 0.020
negative regulation of cell communication GO:0010648 96 0.019
determination of heart left right asymmetry GO:0061371 117 0.019
g2 m transition of mitotic cell cycle GO:0000086 4 0.019
smooth muscle contraction GO:0006939 2 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
regulation of binding GO:0051098 3 0.019
regulation of cell shape GO:0008360 1 0.019
positive regulation of leukocyte differentiation GO:1902107 1 0.018
Mouse
intracellular signal transduction GO:0035556 85 0.018
Mouse
regulation of cell fate commitment GO:0010453 22 0.018
proteasomal protein catabolic process GO:0010498 2 0.018
cell morphogenesis involved in differentiation GO:0000904 195 0.018
transcription from rna polymerase ii promoter GO:0006366 80 0.018
regulation of calcium ion transport GO:0051924 2 0.018
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.018
establishment of protein localization to organelle GO:0072594 4 0.018
regulation of mapk cascade GO:0043408 14 0.017
regulation of signaling GO:0023051 235 0.017
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.017
organism emergence from protective structure GO:0071684 4 0.017
response to lipid GO:0033993 60 0.016
cell substrate junction assembly GO:0007044 2 0.016
tyrosine metabolic process GO:0006570 1 0.016
cellular response to organic substance GO:0071310 105 0.016
b cell activation GO:0042113 2 0.016
Mouse
regulation of macrophage chemotaxis GO:0010758 1 0.016
response to wounding GO:0009611 116 0.016
single organism localization GO:1902578 225 0.016
regulation of cell development GO:0060284 100 0.016
transport GO:0006810 220 0.016
spermatid development GO:0007286 2 0.016
nucleic acid templated transcription GO:0097659 181 0.015
alpha amino acid metabolic process GO:1901605 3 0.015
gland development GO:0048732 143 0.015
positive regulation of transport GO:0051050 2 0.015
pigment biosynthetic process GO:0046148 9 0.015
localization of cell GO:0051674 244 0.015
synaptic target recognition GO:0008039 1 0.015
phagocytosis GO:0006909 3 0.015
mitotic dna damage checkpoint GO:0044773 4 0.015
regulation of jak stat cascade GO:0046425 3 0.015
positive regulation of catabolic process GO:0009896 4 0.015
locomotion GO:0040011 313 0.014
Worm
mononuclear cell proliferation GO:0032943 1 0.014
Mouse
regulation of cell activation GO:0050865 1 0.014
Mouse
muscle organ development GO:0007517 101 0.014
response to stress GO:0006950 263 0.014
Mouse Worm
regulation of signal transduction GO:0009966 225 0.014
taxis GO:0042330 109 0.014
positive regulation of myeloid leukocyte differentiation GO:0002763 1 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.014
purine nucleotide biosynthetic process GO:0006164 20 0.014
Mouse
regulation of organelle assembly GO:1902115 4 0.014
muscle tissue development GO:0060537 110 0.014
positive regulation of leukocyte chemotaxis GO:0002690 1 0.014
regulation of mononuclear cell migration GO:0071675 1 0.014
heart morphogenesis GO:0003007 156 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
developmental programmed cell death GO:0010623 4 0.014
protein metabolic process GO:0019538 183 0.014
positive regulation of metabolic process GO:0009893 108 0.013
Mouse
gene expression GO:0010467 252 0.013
macromolecule modification GO:0043412 111 0.013
response to organic cyclic compound GO:0014070 51 0.013
cellular protein catabolic process GO:0044257 4 0.013
notochord development GO:0030903 54 0.013
negative regulation of sequestering of calcium ion GO:0051283 4 0.013
sequestering of calcium ion GO:0051208 3 0.013
muscle structure development GO:0061061 196 0.013
fat soluble vitamin metabolic process GO:0006775 4 0.013
organic acid metabolic process GO:0006082 31 0.013
Mouse
lens fiber cell morphogenesis GO:0070309 3 0.013
regulation of protein binding GO:0043393 3 0.013
regionalization GO:0003002 274 0.013
melanin metabolic process GO:0006582 2 0.013
single organism reproductive process GO:0044702 40 0.013
cell fate commitment GO:0045165 99 0.013
secondary metabolic process GO:0019748 3 0.013
cytokine production involved in immune response GO:0002367 1 0.013
glial cell differentiation GO:0010001 42 0.013
ion transmembrane transport GO:0034220 91 0.013
cellular response to lipid GO:0071396 39 0.012
epithelial cell differentiation GO:0030855 116 0.012
regulation of cellular ketone metabolic process GO:0010565 7 0.012
positive regulation of cellular process GO:0048522 201 0.012
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.012
Mouse
melanin biosynthetic process GO:0042438 1 0.012
cell fate specification GO:0001708 68 0.012
mitotic dna integrity checkpoint GO:0044774 4 0.012
lymphocyte proliferation GO:0046651 1 0.012
Mouse
erk1 and erk2 cascade GO:0070371 4 0.012
regulation of pigment cell differentiation GO:0050932 2 0.012
amine metabolic process GO:0009308 2 0.012
myeloid cell differentiation GO:0030099 86 0.012
regulation of cellular metabolic process GO:0031323 320 0.012
Mouse
gtp catabolic process GO:0006184 2 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
cartilage development GO:0051216 96 0.012
osteoclast differentiation GO:0030316 1 0.012
phagosome maturation GO:0090382 1 0.012
carbon dioxide transport GO:0015670 3 0.012
intra s dna damage checkpoint GO:0031573 1 0.012
protein alkylation GO:0008213 13 0.012
negative regulation of dna metabolic process GO:0051053 4 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
immune system development GO:0002520 191 0.011
Mouse
positive regulation of ras protein signal transduction GO:0046579 1 0.011
positive regulation of jak stat cascade GO:0046427 2 0.011
phosphorylation GO:0016310 69 0.011
regulation of metabolic process GO:0019222 359 0.011
Mouse
protein targeting to nucleus GO:0044744 3 0.011
oxoacid metabolic process GO:0043436 31 0.011
regulation of bone mineralization GO:0030500 2 0.011
sequestering of metal ion GO:0051238 3 0.011
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.011
heart development GO:0007507 313 0.011
protein import GO:0017038 3 0.011
protein localization to nucleus GO:0034504 3 0.011
axon ensheathment in central nervous system GO:0032291 2 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.010
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.010
trabecula formation GO:0060343 2 0.010
central nervous system myelination GO:0022010 2 0.010
activation of mapk activity GO:0000187 3 0.010
lens fiber cell development GO:0070307 3 0.010
negative regulation of multicellular organismal process GO:0051241 69 0.010
somitogenesis GO:0001756 87 0.010
regulation of melanocyte differentiation GO:0045634 2 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
chromatin organization GO:0006325 22 0.010

pnp4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.075
disease of anatomical entity DOID:7 0 0.075
cancer DOID:162 0 0.064
disease of cellular proliferation DOID:14566 0 0.064
organ system cancer DOID:0050686 0 0.029
hematopoietic system disease DOID:74 0 0.021
musculoskeletal system cancer DOID:0060100 0 0.021
auditory system disease DOID:2742 0 0.021
nonsyndromic deafness DOID:0050563 0 0.021
sensory system disease DOID:0050155 0 0.021
nervous system disease DOID:863 0 0.021