Danio rerio

14 known processes

pou4f2

POU domain, class 4, transcription factor 2

(Aliases: brn-3b,brn3.2)

pou4f2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to chemical GO:0042221 320 0.627
Mouse Fly
response to alkaloid GO:0043279 2 0.461
eye development GO:0001654 277 0.386
Mouse
sensory organ development GO:0007423 393 0.347
Mouse
ion transport GO:0006811 114 0.320
regulation of multicellular organismal development GO:2000026 223 0.313
Zebrafish
head development GO:0060322 303 0.302
gastrulation GO:0007369 208 0.281
Zebrafish
regulation of neurogenesis GO:0050767 87 0.245
neuron differentiation GO:0030182 353 0.223
Mouse Worm Fly
mechanosensory lateral line system development GO:0048881 49 0.200
cell surface receptor signaling pathway GO:0007166 325 0.194
transport GO:0006810 220 0.187
neuron projection development GO:0031175 180 0.185
Mouse Worm Fly
sleep GO:0030431 1 0.156
tube morphogenesis GO:0035239 349 0.150
Zebrafish
sensory system development GO:0048880 76 0.138
embryonic viscerocranium morphogenesis GO:0048703 52 0.138
central nervous system development GO:0007417 387 0.134
positive regulation of biological process GO:0048518 253 0.126
Human Zebrafish Mouse Worm Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.120
Human Zebrafish Mouse Worm Fly
response to external stimulus GO:0009605 264 0.118
Mouse Worm Fly
establishment of localization GO:0051234 244 0.117
digestive system development GO:0055123 289 0.108
Zebrafish
response to xenobiotic stimulus GO:0009410 45 0.107
posterior lateral line nerve development GO:0048918 8 0.106
inorganic anion transport GO:0015698 25 0.106
inorganic anion transmembrane transport GO:0098661 10 0.099
organelle localization GO:0051640 49 0.098
embryonic organ development GO:0048568 381 0.098
cellular protein catabolic process GO:0044257 4 0.098
embryonic organ morphogenesis GO:0048562 274 0.097
response to amino acid GO:0043200 2 0.096
cellular macromolecule metabolic process GO:0044260 391 0.094
Human Zebrafish Mouse Worm Fly
system process GO:0003008 185 0.093
Mouse Fly
circadian sleep wake cycle process GO:0022410 2 0.093
regulation of macromolecule metabolic process GO:0060255 317 0.092
Human Zebrafish Mouse Worm Fly
sensory organ morphogenesis GO:0090596 200 0.092
glomerular epithelial cell fate commitment GO:0072314 4 0.089
neuron neuron synaptic transmission GO:0007270 1 0.087
axon guidance GO:0007411 86 0.085
Mouse Fly
posterior lateral line system development GO:0048915 46 0.084
transmembrane transport GO:0055085 120 0.082
regulation of circadian rhythm GO:0042752 4 0.081
single organism localization GO:1902578 225 0.081
camera type eye development GO:0043010 222 0.081
Mouse
skeletal system morphogenesis GO:0048705 102 0.079
response to amphetamine GO:0001975 1 0.077
nitrogen compound metabolic process GO:0006807 319 0.077
Human Zebrafish Mouse Worm Fly
neural retina development GO:0003407 49 0.076
regulation of cellular metabolic process GO:0031323 320 0.076
Human Zebrafish Mouse Worm Fly
regulation of cell differentiation GO:0045595 142 0.075
Zebrafish Mouse
adult behavior GO:0030534 2 0.075
Fly
brain development GO:0007420 293 0.075
response to nicotine GO:0035094 2 0.075
pancreatic a cell development GO:0003322 2 0.074
gene expression GO:0010467 252 0.073
Human Zebrafish Mouse Worm Fly
posterior lateral line development GO:0048916 38 0.073
nerve development GO:0021675 45 0.070
regulation of synaptic plasticity GO:0048167 1 0.069
regulation of multicellular organismal process GO:0051239 277 0.068
Zebrafish
modification dependent protein catabolic process GO:0019941 3 0.066
embryonic skeletal system morphogenesis GO:0048704 93 0.066
chloride transport GO:0006821 8 0.065
entrainment of circadian clock GO:0009649 2 0.065
lateral line system development GO:0048925 76 0.063
cognition GO:0050890 1 0.062
regulation of circadian sleep wake cycle GO:0042749 1 0.062
fin development GO:0033333 77 0.062
regulation of cellular biosynthetic process GO:0031326 245 0.061
Human Zebrafish Mouse Worm Fly
regulation of developmental process GO:0050793 247 0.061
Zebrafish Mouse
morphogenesis of an epithelium GO:0002009 333 0.060
Zebrafish
regulation of biosynthetic process GO:0009889 250 0.059
Human Zebrafish Mouse Worm Fly
hindbrain development GO:0030902 91 0.059
Zebrafish
carboxylic acid catabolic process GO:0046395 3 0.058
embryonic skeletal system development GO:0048706 97 0.057
myeloid cell differentiation GO:0030099 86 0.057
endocrine system development GO:0035270 65 0.057
digestive tract development GO:0048565 265 0.055
Zebrafish
peptide transport GO:0015833 1 0.055
forebrain development GO:0030900 96 0.054
single organism transport GO:0044765 206 0.054
cellular nitrogen compound metabolic process GO:0034641 290 0.054
Human Zebrafish Mouse Worm Fly
cell motility GO:0048870 244 0.053
regulation of nervous system development GO:0051960 90 0.051
axon development GO:0061564 166 0.051
Mouse Fly
regulation of transcription dna templated GO:0006355 213 0.051
Human Zebrafish Mouse Worm Fly
regulation of embryonic development GO:0045995 47 0.051
Zebrafish
segmentation GO:0035282 97 0.050
Zebrafish
cell projection morphogenesis GO:0048858 244 0.050
Mouse Fly
cellular aromatic compound metabolic process GO:0006725 295 0.050
Human Zebrafish Mouse Worm Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.050
Human Zebrafish Mouse Worm Fly
embryonic heart tube development GO:0035050 133 0.049
cell cell signaling GO:0007267 52 0.048
nucleobase containing compound biosynthetic process GO:0034654 205 0.048
Human Zebrafish Mouse Worm Fly
locomotion GO:0040011 313 0.048
Mouse Worm Fly
response to glucose GO:0009749 3 0.047
eye morphogenesis GO:0048592 144 0.046
epithelial cell development GO:0002064 42 0.046
cellular response to chemical stimulus GO:0070887 157 0.046
regulation of sequestering of calcium ion GO:0051282 4 0.045
cranial nerve development GO:0021545 42 0.044
rna metabolic process GO:0016070 219 0.044
Human Zebrafish Mouse Worm Fly
reflex GO:0060004 2 0.042
generation of neurons GO:0048699 385 0.041
Mouse Worm Fly
organic substance biosynthetic process GO:1901576 289 0.040
Human Zebrafish Mouse Worm Fly
regulation of ion transmembrane transporter activity GO:0032412 2 0.040
inorganic ion transmembrane transport GO:0098660 57 0.040
camera type eye morphogenesis GO:0048593 108 0.040
dopamine metabolic process GO:0042417 2 0.040
nucleic acid metabolic process GO:0090304 244 0.040
Human Zebrafish Mouse Worm Fly
regulation of localization GO:0032879 104 0.039
larval development GO:0002164 2 0.039
negative regulation of behavior GO:0048521 6 0.039
g protein coupled receptor signaling pathway GO:0007186 74 0.039
intracellular estrogen receptor signaling pathway GO:0030520 3 0.039
Human
negative regulation of protein phosphorylation GO:0001933 4 0.039
embryonic cranial skeleton morphogenesis GO:0048701 90 0.038
septum transversum development GO:0003343 4 0.037
compound eye development GO:0048749 2 0.036
cellular biosynthetic process GO:0044249 286 0.036
Human Zebrafish Mouse Worm Fly
ion transmembrane transport GO:0034220 91 0.036
forebrain neuron development GO:0021884 7 0.036
proepicardium development GO:0003342 4 0.035
lateral line development GO:0048882 66 0.035
small molecule metabolic process GO:0044281 77 0.035
negative regulation of cellular process GO:0048523 283 0.035
Mouse Fly
localization of cell GO:0051674 244 0.034
chloride transmembrane transport GO:1902476 4 0.034
renal system development GO:0072001 94 0.033
cytokinesis GO:0000910 3 0.033
nucleobase containing compound metabolic process GO:0006139 274 0.033
Human Zebrafish Mouse Worm Fly
nitrogen compound transport GO:0071705 23 0.032
monoamine transport GO:0015844 1 0.032
heterocycle biosynthetic process GO:0018130 215 0.031
Human Zebrafish Mouse Worm Fly
cellular component assembly GO:0022607 170 0.031
mesoderm formation GO:0001707 43 0.031
intracellular signal transduction GO:0035556 85 0.031
Human
regulation of sodium ion transport GO:0002028 2 0.031
cellular macromolecule biosynthetic process GO:0034645 224 0.031
Human Zebrafish Mouse Worm Fly
sequestering of calcium ion GO:0051208 3 0.031
multi organism process GO:0051704 134 0.030
Worm
pancreas development GO:0031016 84 0.030
response to organic substance GO:0010033 153 0.030
endocardium formation GO:0060214 1 0.029
sequestering of metal ion GO:0051238 3 0.029
response to food GO:0032094 1 0.029
cardiocyte differentiation GO:0035051 44 0.029
hematopoietic or lymphoid organ development GO:0048534 191 0.029
organonitrogen compound metabolic process GO:1901564 74 0.029
gastrulation with mouth forming second GO:0001702 44 0.029
Zebrafish
heterocycle metabolic process GO:0046483 290 0.029
Human Zebrafish Mouse Worm Fly
protein localization to nucleus GO:0034504 3 0.029
regulation of cell development GO:0060284 100 0.028
hormone secretion GO:0046879 2 0.028
forebrain cell migration GO:0021885 1 0.028
negative regulation of multicellular organismal process GO:0051241 69 0.028
positive regulation of cellular component biogenesis GO:0044089 3 0.028
rhythmic behavior GO:0007622 5 0.028
phagocytosis GO:0006909 3 0.028
negative regulation of phosphate metabolic process GO:0045936 13 0.027
organonitrogen compound biosynthetic process GO:1901566 47 0.027
regulation of hormone secretion GO:0046883 2 0.027
positive regulation of multicellular organismal process GO:0051240 52 0.027
regulation of reproductive process GO:2000241 4 0.026
convergent extension GO:0060026 118 0.026
peripheral nervous system neuron differentiation GO:0048934 28 0.026
regulation of nitrogen compound metabolic process GO:0051171 251 0.026
Human Zebrafish Mouse Worm Fly
negative regulation of protein kinase activity GO:0006469 4 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.026
epidermal cell differentiation GO:0009913 36 0.025
cellular nitrogen compound biosynthetic process GO:0044271 218 0.025
Human Zebrafish Mouse Worm Fly
neuromuscular synaptic transmission GO:0007274 2 0.025
response to stress GO:0006950 263 0.025
Zebrafish
positive regulation of developmental process GO:0051094 50 0.025
Mouse
regulation of tube size GO:0035150 2 0.025
regulation of transport GO:0051049 45 0.024
cardiogenic plate morphogenesis GO:0003142 1 0.024
transcription from rna polymerase ii promoter GO:0006366 80 0.024
Human Mouse Worm Fly
multicellular organism growth GO:0035264 4 0.024
cell morphogenesis GO:0000902 289 0.024
Mouse Fly
neuron fate determination GO:0048664 2 0.024
organic cyclic compound metabolic process GO:1901360 301 0.023
Human Zebrafish Mouse Worm Fly
chondrocyte intercalation involved in growth plate cartilage morphogenesis GO:0003428 1 0.023
negative regulation of biological process GO:0048519 304 0.023
Mouse Fly
regulation of metabolic process GO:0019222 359 0.023
Human Zebrafish Mouse Worm Fly
regulation of transporter activity GO:0032409 2 0.023
cellular component movement GO:0006928 335 0.023
Mouse Fly
establishment of localization in cell GO:0051649 77 0.023
erythrocyte homeostasis GO:0034101 55 0.022
regulation of primary metabolic process GO:0080090 311 0.022
Human Zebrafish Mouse Worm Fly
regulation of cell communication GO:0010646 232 0.022
regulation of transmembrane transport GO:0034762 18 0.022
response to endogenous stimulus GO:0009719 83 0.022
polarized epithelial cell differentiation GO:0030859 4 0.022
developmental growth GO:0048589 166 0.022
Zebrafish Mouse
regulation of ion transmembrane transport GO:0034765 18 0.022
cell recognition GO:0008037 19 0.021
Fly
cellular chemical homeostasis GO:0055082 17 0.021
aging GO:0007568 2 0.021
regulation of behavior GO:0050795 24 0.021
heart development GO:0007507 313 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.021
Human Mouse Worm Fly
positive regulation of cellular process GO:0048522 201 0.020
Human Zebrafish Mouse Worm Fly
neuron development GO:0048666 262 0.020
Mouse Worm Fly
cellular protein metabolic process GO:0044267 129 0.020
glomerular visceral epithelial cell fate commitment GO:0072149 4 0.020
female gonad development GO:0008585 4 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
cell migration GO:0016477 237 0.020
negative regulation of metabolic process GO:0009892 86 0.020
Mouse Fly
morphogenesis of embryonic epithelium GO:0016331 30 0.020
Zebrafish
mechanosensory behavior GO:0007638 2 0.020
Worm
axon regeneration GO:0031103 14 0.019
morphogenesis of an epithelial sheet GO:0002011 49 0.019
Zebrafish
positive regulation of signaling GO:0023056 56 0.019
kidney development GO:0001822 92 0.019
negative regulation of signaling GO:0023057 96 0.019
taxis GO:0042330 109 0.019
Mouse Fly
regulation of establishment of protein localization GO:0070201 4 0.019
negative regulation of sequestering of calcium ion GO:0051283 4 0.019
cellular component morphogenesis GO:0032989 336 0.019
Mouse Fly
negative regulation of cellular metabolic process GO:0031324 77 0.019
Mouse Fly
positive regulation of transport GO:0051050 2 0.018
regulation of axon extension GO:0030516 24 0.018
regulation of growth GO:0040008 42 0.018
cellular cation homeostasis GO:0030003 17 0.018
hemopoiesis GO:0030097 183 0.018
post embryonic organ morphogenesis GO:0048563 1 0.018
endocardium morphogenesis GO:0003160 4 0.018
hair cell differentiation GO:0035315 32 0.018
hormone transport GO:0009914 2 0.018
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.018
Human Zebrafish Mouse Worm Fly
circadian regulation of gene expression GO:0032922 8 0.018
regulation of rna biosynthetic process GO:2001141 213 0.017
Human Zebrafish Mouse Worm Fly
protein modification process GO:0036211 100 0.017
phosphorus metabolic process GO:0006793 109 0.017
Human
blood circulation GO:0008015 87 0.017
retina morphogenesis in camera type eye GO:0060042 79 0.017
regulation of blood circulation GO:1903522 32 0.017
locomotory behavior GO:0007626 34 0.017
Fly
glomerulus development GO:0032835 27 0.017
regulation of rna metabolic process GO:0051252 224 0.017
Human Zebrafish Mouse Worm Fly
regulation of gene expression GO:0010468 265 0.017
Human Zebrafish Mouse Worm Fly
carbohydrate derivative biosynthetic process GO:1901137 43 0.017
digestive tract morphogenesis GO:0048546 231 0.016
Zebrafish
endochondral bone growth GO:0003416 2 0.016
regulation of blood vessel size GO:0050880 2 0.016
regulation of cellular protein metabolic process GO:0032268 52 0.016
single organism metabolic process GO:0044710 217 0.016
Human
determination of bilateral symmetry GO:0009855 204 0.016
positive regulation of catabolic process GO:0009896 4 0.016
angiogenesis GO:0001525 158 0.016
phosphate containing compound metabolic process GO:0006796 108 0.016
Human
epithelial tube morphogenesis GO:0060562 148 0.016
growth plate cartilage development GO:0003417 2 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.016
Human Zebrafish Mouse Worm Fly
cell part morphogenesis GO:0032990 246 0.016
Mouse Fly
regulation of synapse organization GO:0050807 3 0.016
phenol containing compound biosynthetic process GO:0046189 4 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.015
Mouse Fly
regulation of system process GO:0044057 40 0.015
behavior GO:0007610 74 0.015
Worm Fly
epidermis development GO:0008544 48 0.015
regulation of phosphate metabolic process GO:0019220 43 0.015
protein secretion GO:0009306 1 0.015
regulation of inflammatory response GO:0050727 2 0.015
homeostatic process GO:0042592 142 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
cation transport GO:0006812 81 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.015
regulation of cellular component organization GO:0051128 86 0.015
ribonucleotide metabolic process GO:0009259 27 0.015
posterior lateral line neuromast hair cell differentiation GO:0048923 8 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.015
Mouse Fly
guanosine containing compound catabolic process GO:1901069 2 0.015
positive regulation of gene expression GO:0010628 71 0.015
Human Zebrafish Mouse Worm Fly
cation homeostasis GO:0055080 33 0.015
circadian sleep wake cycle sleep GO:0050802 1 0.014
immune system process GO:0002376 241 0.014
response to external biotic stimulus GO:0043207 97 0.014
growth GO:0040007 174 0.014
Zebrafish Mouse
growth plate cartilage morphogenesis GO:0003422 1 0.014
negative regulation of cell development GO:0010721 26 0.014
regulation of neuronal synaptic plasticity GO:0048168 1 0.014
mechanoreceptor differentiation GO:0042490 37 0.014
regulation of metal ion transport GO:0010959 4 0.014
otolith formation GO:0032475 2 0.014
convergent extension involved in organogenesis GO:0060029 10 0.014
organelle organization GO:0006996 227 0.014
neuron projection morphogenesis GO:0048812 161 0.014
Mouse Fly
positive regulation of endothelial cell differentiation GO:0045603 2 0.014
cell differentiation involved in kidney development GO:0061005 13 0.014
macromolecule biosynthetic process GO:0009059 227 0.014
Human Zebrafish Mouse Worm Fly
synaptic transmission GO:0007268 35 0.013
wnt signaling pathway GO:0016055 80 0.013
synaptic growth at neuromuscular junction GO:0051124 2 0.013
embryonic camera type eye morphogenesis GO:0048596 19 0.013
chordate embryonic development GO:0043009 271 0.013
anterior lateral line nerve development GO:0048909 4 0.013
catabolic process GO:0009056 32 0.013
positive regulation of cell cycle GO:0045787 3 0.013
myeloid cell development GO:0061515 32 0.013
response to light stimulus GO:0009416 46 0.013
cellular component biogenesis GO:0044085 178 0.013
chemical homeostasis GO:0048878 49 0.013
response to drug GO:0042493 3 0.013
olfactory lobe development GO:0021988 4 0.013
anterior posterior pattern specification GO:0009952 152 0.013
regulation of heart contraction GO:0008016 32 0.013
organophosphate metabolic process GO:0019637 37 0.013
organic hydroxy compound transport GO:0015850 14 0.012
forebrain regionalization GO:0021871 4 0.012
regulation of intracellular signal transduction GO:1902531 57 0.012
auditory receptor cell fate commitment GO:0009912 4 0.012
retina development in camera type eye GO:0060041 146 0.012
Mouse
negative regulation of defense response GO:0031348 2 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
apoptotic process involved in development GO:1902742 2 0.012
cellular response to external stimulus GO:0071496 2 0.012
rhombomere formation GO:0021594 12 0.012
steroid hormone mediated signaling pathway GO:0043401 9 0.011
regulation of signaling GO:0023051 235 0.011
female sex differentiation GO:0046660 4 0.011
central nervous system neuron differentiation GO:0021953 74 0.011
regulation of neuron projection regeneration GO:0070570 7 0.011
regulation of phosphorylation GO:0042325 26 0.011
positive regulation of nervous system development GO:0051962 25 0.011
cellular response to organic substance GO:0071310 105 0.011
response to axon injury GO:0048678 14 0.011
maintenance of location GO:0051235 4 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
Zebrafish
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.011
cellular homeostasis GO:0019725 26 0.011
blood vessel development GO:0001568 246 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
Mouse Fly
mesodermal cell differentiation GO:0048333 21 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
sodium ion transport GO:0006814 24 0.011
keratinocyte differentiation GO:0030216 0 0.011
regulation of extent of cell growth GO:0061387 29 0.011
positive regulation of cell development GO:0010720 25 0.011
biosynthetic process GO:0009058 294 0.011
Human Zebrafish Mouse Worm Fly
regulation of hydrolase activity GO:0051336 28 0.011
regulation of calcium ion transport GO:0051924 2 0.011
positive regulation of microtubule polymerization or depolymerization GO:0031112 3 0.011
regeneration GO:0031099 91 0.011
Zebrafish
forebrain anterior posterior pattern specification GO:0021797 3 0.011
regulation of protein ubiquitination GO:0031396 3 0.011
cell differentiation in spinal cord GO:0021515 40 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
actin filament based process GO:0030029 64 0.010
regulation of lipid catabolic process GO:0050994 2 0.010
immune system development GO:0002520 191 0.010
lipid digestion GO:0044241 3 0.010
nucleotide metabolic process GO:0009117 28 0.010
regionalization GO:0003002 274 0.010
Zebrafish
heart morphogenesis GO:0003007 156 0.010
negative regulation of macromolecule metabolic process GO:0010605 76 0.010
Mouse Fly
enzyme linked receptor protein signaling pathway GO:0007167 106 0.010

pou4f2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
connective tissue disease DOID:65 0 0.018
osteochondrodysplasia DOID:2256 0 0.018
bone development disease DOID:0080006 0 0.018
musculoskeletal system disease DOID:17 0 0.018
bone disease DOID:0080001 0 0.018
nervous system disease DOID:863 0 0.010