Danio rerio

0 known processes

ppt1

palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)

(Aliases: zgc:63969,wu:fj17f04)

ppt1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organelle fusion GO:0048284 3 0.129
cytoskeleton dependent cytokinesis GO:0061640 3 0.106
superoxide metabolic process GO:0006801 2 0.098
cytokinetic process GO:0032506 2 0.096
membrane fusion GO:0061025 2 0.087
regulation of cell shape GO:0008360 1 0.068
secondary metabolic process GO:0019748 3 0.059
gtp catabolic process GO:0006184 2 0.059
positive regulation of transport GO:0051050 2 0.059
Human Fly
endosomal transport GO:0016197 2 0.057
single organism membrane fusion GO:0044801 2 0.056
protein metabolic process GO:0019538 183 0.054
Human Fly
mitotic cytokinesis GO:0000281 3 0.053
guanosine containing compound metabolic process GO:1901068 4 0.052
regulation of protein catabolic process GO:0042176 1 0.049
autophagy GO:0006914 4 0.048
larval development GO:0002164 2 0.046
rna localization GO:0006403 4 0.045
cellular protein catabolic process GO:0044257 4 0.045
cortical actin cytoskeleton organization GO:0030866 1 0.039
transport GO:0006810 220 0.038
Human Fly
single organism metabolic process GO:0044710 217 0.038
Human
centrosome cycle GO:0007098 1 0.036
stem cell proliferation GO:0072089 4 0.036
guanosine containing compound catabolic process GO:1901069 2 0.035
protein modification process GO:0036211 100 0.035
Human Fly
regulation of macromolecule metabolic process GO:0060255 317 0.033
positive regulation of protein complex assembly GO:0031334 2 0.033
regulation of protein complex assembly GO:0043254 3 0.033
meiotic nuclear division GO:0007126 4 0.032
compound eye development GO:0048749 2 0.032
release of sequestered calcium ion into cytosol GO:0051209 3 0.032
neuroblast proliferation GO:0007405 2 0.031
glial cell migration GO:0008347 3 0.031
sensory organ development GO:0007423 393 0.031
cortical cytoskeleton organization GO:0030865 1 0.031
meiotic cell cycle process GO:1903046 3 0.031
modification dependent macromolecule catabolic process GO:0043632 3 0.030
establishment of protein localization to organelle GO:0072594 4 0.030
proteasomal protein catabolic process GO:0010498 2 0.030
ubiquitin dependent protein catabolic process GO:0006511 3 0.029
cellular protein metabolic process GO:0044267 129 0.029
Human Fly
signal transduction GO:0007165 455 0.029
nitrogen compound metabolic process GO:0006807 319 0.028
localization of cell GO:0051674 244 0.028
heterocycle biosynthetic process GO:0018130 215 0.028
microtubule organizing center organization GO:0031023 1 0.027
cellular response to nutrient levels GO:0031669 2 0.026
death GO:0016265 121 0.026
Human
cellular aromatic compound metabolic process GO:0006725 295 0.026
regulation of filopodium assembly GO:0051489 2 0.026
antimicrobial humoral response GO:0019730 2 0.026
cellular response to external stimulus GO:0071496 2 0.026
membrane invagination GO:0010324 1 0.026
establishment of rna localization GO:0051236 3 0.025
cellular response to starvation GO:0009267 1 0.025
protein polyubiquitination GO:0000209 4 0.025
mitotic dna damage checkpoint GO:0044773 4 0.025
regulation of cytoplasmic transport GO:1903649 4 0.024
modification dependent protein catabolic process GO:0019941 3 0.024
cellular macromolecule metabolic process GO:0044260 391 0.024
Human Fly
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.024
embryo development ending in birth or egg hatching GO:0009792 271 0.024
protein localization to plasma membrane GO:0072659 1 0.024
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.024
positive regulation of cellular process GO:0048522 201 0.024
Fly
centrosome organization GO:0051297 1 0.024
cellular ketone metabolic process GO:0042180 11 0.023
eye development GO:0001654 277 0.023
response to wounding GO:0009611 116 0.022
cellular response to extracellular stimulus GO:0031668 2 0.022
apoptotic process involved in development GO:1902742 2 0.022
stem cell maintenance GO:0019827 4 0.022
oxoacid metabolic process GO:0043436 31 0.022
response to glucocorticoid GO:0051384 1 0.022
regulation of transmembrane transporter activity GO:0022898 2 0.021
regulation of metal ion transport GO:0010959 4 0.021
xenobiotic metabolic process GO:0006805 4 0.021
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.021
regulation of reactive oxygen species metabolic process GO:2000377 2 0.021
meiotic chromosome segregation GO:0045132 3 0.020
cell motility GO:0048870 244 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
cellular localization GO:0051641 97 0.020
Fly
regulation of cellular ph GO:0030641 1 0.020
Human
negative regulation of synapse assembly GO:0051964 2 0.020
positive regulation of cellular component biogenesis GO:0044089 3 0.019
negative regulation of biological process GO:0048519 304 0.019
Human
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.019
gtp metabolic process GO:0046039 4 0.019
cell surface receptor signaling pathway GO:0007166 325 0.019
internal protein amino acid acetylation GO:0006475 2 0.019
regulation of cytokine production GO:0001817 3 0.019
peptide transport GO:0015833 1 0.019
positive regulation of cell cycle GO:0045787 3 0.019
nucleic acid transport GO:0050657 2 0.019
regulation of signaling GO:0023051 235 0.019
Fly
cell projection morphogenesis GO:0048858 244 0.018
Fly
cell death GO:0008219 121 0.018
Human
stem cell division GO:0017145 1 0.018
maintenance of location GO:0051235 4 0.018
aging GO:0007568 2 0.018
Fly
neurotransmitter transport GO:0006836 2 0.018
regulation of embryonic development GO:0045995 47 0.018
nucleobase containing compound transport GO:0015931 2 0.018
regulation of intracellular ph GO:0051453 1 0.018
Human
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
golgi vesicle transport GO:0048193 3 0.018
regulation of cell projection assembly GO:0060491 4 0.018
organic substance biosynthetic process GO:1901576 289 0.018
regulation of cellular amino acid metabolic process GO:0006521 0 0.018
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
macromolecule biosynthetic process GO:0009059 227 0.017
regulation of cellular protein catabolic process GO:1903362 1 0.017
small molecule metabolic process GO:0044281 77 0.017
regulation of response to oxidative stress GO:1902882 2 0.017
protein acylation GO:0043543 3 0.017
ion transmembrane transport GO:0034220 91 0.017
multicellular organism growth GO:0035264 4 0.016
establishment of synaptic vesicle localization GO:0097480 1 0.016
Fly
axonogenesis GO:0007409 152 0.016
Fly
cation transport GO:0006812 81 0.016
i kappab kinase nf kappab signaling GO:0007249 4 0.016
determination of bilateral symmetry GO:0009855 204 0.016
nucleobase containing compound metabolic process GO:0006139 274 0.016
single organism membrane organization GO:0044802 20 0.016
Human
positive regulation of catabolic process GO:0009896 4 0.016
organonitrogen compound metabolic process GO:1901564 74 0.016
regulation of response to stimulus GO:0048583 269 0.016
Fly
retina development in camera type eye GO:0060041 146 0.016
calcium ion transport into cytosol GO:0060402 3 0.016
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.016
phagocytosis GO:0006909 3 0.016
response to stress GO:0006950 263 0.016
regulation of wound healing GO:0061041 2 0.016
regulation of protein transport GO:0051223 3 0.016
cellular nitrogen compound metabolic process GO:0034641 290 0.016
actin filament based movement GO:0030048 1 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
regulation of cell communication GO:0010646 232 0.015
Fly
regulation of transporter activity GO:0032409 2 0.015
regulation of cell differentiation GO:0045595 142 0.015
Fly
cellular protein modification process GO:0006464 100 0.015
Human Fly
positive regulation of secretion by cell GO:1903532 1 0.015
lateral inhibition GO:0046331 1 0.015
mitotic dna integrity checkpoint GO:0044774 4 0.015
protein polymerization GO:0051258 4 0.015
specification of symmetry GO:0009799 204 0.015
cellular component movement GO:0006928 335 0.015
Fly
establishment of localization GO:0051234 244 0.015
Human Fly
cytosolic calcium ion transport GO:0060401 3 0.015
tissue remodeling GO:0048771 4 0.015
response to unfolded protein GO:0006986 2 0.015
regulation of jun kinase activity GO:0043506 3 0.014
negative regulation of sequestering of calcium ion GO:0051283 4 0.014
germ line stem cell maintenance GO:0030718 2 0.014
cellular component biogenesis GO:0044085 178 0.014
sequestering of calcium ion GO:0051208 3 0.014
cellular component morphogenesis GO:0032989 336 0.014
Fly
regulation of protein metabolic process GO:0051246 56 0.014
determination of left right symmetry GO:0007368 179 0.014
response to corticosteroid GO:0031960 1 0.014
biosynthetic process GO:0009058 294 0.014
regulation of synapse organization GO:0050807 3 0.014
rna transport GO:0050658 2 0.014
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.014
regulation of synaptic plasticity GO:0048167 1 0.014
amine metabolic process GO:0009308 2 0.014
cytoplasm organization GO:0007028 4 0.014
response to topologically incorrect protein GO:0035966 2 0.014
leukocyte proliferation GO:0070661 1 0.014
exocytosis GO:0006887 1 0.014
melanin metabolic process GO:0006582 2 0.013
cellular amine metabolic process GO:0044106 2 0.013
heterocycle metabolic process GO:0046483 290 0.013
regulation of ion transmembrane transporter activity GO:0032412 2 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
gland development GO:0048732 143 0.013
organelle organization GO:0006996 227 0.013
Human
positive regulation of secretion GO:0051047 1 0.013
regulation of cell projection organization GO:0031344 44 0.013
Fly
positive regulation of stem cell proliferation GO:2000648 1 0.013
interspecies interaction between organisms GO:0044419 4 0.013
double strand break repair GO:0006302 3 0.013
regulation of multicellular organism growth GO:0040014 4 0.013
regulation of primary metabolic process GO:0080090 311 0.013
cellular response to topologically incorrect protein GO:0035967 2 0.013
protein dephosphorylation GO:0006470 3 0.013
regulation of stem cell differentiation GO:2000736 4 0.013
regulation of multicellular organismal process GO:0051239 277 0.013
Fly
negative regulation of signaling GO:0023057 96 0.013
cytokinesis GO:0000910 3 0.013
organic substance transport GO:0071702 58 0.013
Human
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.013
er nucleus signaling pathway GO:0006984 2 0.013
regulation of sequestering of calcium ion GO:0051282 4 0.013
blood vessel development GO:0001568 246 0.013
epithelial cell morphogenesis GO:0003382 2 0.013
response to uv GO:0009411 3 0.013
pole plasm assembly GO:0007315 4 0.013
regulation of binding GO:0051098 3 0.013
blood vessel morphogenesis GO:0048514 216 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
nephron epithelium morphogenesis GO:0072088 1 0.013
internal peptidyl lysine acetylation GO:0018393 2 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
protein acetylation GO:0006473 2 0.012
immune response GO:0006955 28 0.012
programmed cell death GO:0012501 119 0.012
Human
cellular response to unfolded protein GO:0034620 2 0.012
neuron differentiation GO:0030182 353 0.012
Fly
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.012
regulation of intracellular protein transport GO:0033157 3 0.012
double strand break repair via homologous recombination GO:0000724 1 0.012
vacuolar transport GO:0007034 2 0.012
regulation of synapse assembly GO:0051963 3 0.012
intracellular signal transduction GO:0035556 85 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
positive regulation of protein polymerization GO:0032273 2 0.012
negative regulation of cell communication GO:0010648 96 0.012
negative regulation of cytokine production GO:0001818 1 0.012
actin mediated cell contraction GO:0070252 1 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.012
regulation of blood vessel size GO:0050880 2 0.012
synaptic vesicle recycling GO:0036465 1 0.012
Fly
regulation of cellular response to oxidative stress GO:1900407 2 0.012
sensory perception of chemical stimulus GO:0007606 3 0.012
apoptotic process GO:0006915 116 0.012
Human
response to drug GO:0042493 3 0.012
regulation of hormone secretion GO:0046883 2 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
synaptic growth at neuromuscular junction GO:0051124 2 0.011
regulation of neurotransmitter secretion GO:0046928 1 0.011
regulation of reproductive process GO:2000241 4 0.011
regulation of blood pressure GO:0008217 1 0.011
microtubule based process GO:0007017 60 0.011
recombinational repair GO:0000725 1 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
endoplasmic reticulum unfolded protein response GO:0030968 2 0.011
cellular amide metabolic process GO:0043603 4 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
regulation of carbohydrate metabolic process GO:0006109 4 0.011
immune system process GO:0002376 241 0.011
cation transmembrane transport GO:0098655 65 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
Fly
phosphate containing compound metabolic process GO:0006796 108 0.011
developmental programmed cell death GO:0010623 4 0.011
multi organism cellular process GO:0044764 2 0.011
sequestering of metal ion GO:0051238 3 0.011
macroautophagy GO:0016236 1 0.011
mitochondrion organization GO:0007005 4 0.011
regulation of ph GO:0006885 3 0.011
Human
spindle assembly involved in mitosis GO:0090307 1 0.011
enzyme linked receptor protein signaling pathway GO:0007167 106 0.011
inorganic cation transmembrane transport GO:0098662 50 0.011
organic acid metabolic process GO:0006082 31 0.011
neurotransmitter secretion GO:0007269 2 0.011
sex determination GO:0007530 1 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
negative regulation of kinase activity GO:0033673 4 0.011
negative regulation of multi organism process GO:0043901 3 0.011
phagocytosis engulfment GO:0006911 1 0.011
mitotic cell cycle GO:0000278 64 0.011
nuclear import GO:0051170 3 0.011
macromolecule modification GO:0043412 111 0.011
Human Fly
synaptic vesicle transport GO:0048489 1 0.011
Fly
regulation of protein ubiquitination GO:0031396 3 0.011
regulation of meiotic cell cycle GO:0051445 1 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
organic cyclic compound metabolic process GO:1901360 301 0.011
positive regulation of cell division GO:0051781 2 0.011
telomere maintenance GO:0000723 1 0.011
peptide metabolic process GO:0006518 1 0.010
single organism organelle organization GO:1902589 199 0.010
positive regulation of apoptotic signaling pathway GO:2001235 1 0.010
cell cycle process GO:0022402 53 0.010
cellular response to biotic stimulus GO:0071216 3 0.010
regulation of apoptotic process GO:0042981 98 0.010
Human
regulation of cell activation GO:0050865 1 0.010
cellular pigmentation GO:0033059 30 0.010
regulation of epithelial cell proliferation GO:0050678 3 0.010
regulation of multicellular organismal development GO:2000026 223 0.010
Fly
single organism nuclear import GO:1902593 3 0.010
regulation of oocyte development GO:0060281 3 0.010
toxin metabolic process GO:0009404 1 0.010
cellular response to stress GO:0033554 62 0.010
intracellular mrna localization GO:0008298 1 0.010
protein import GO:0017038 3 0.010
regulation of gtpase activity GO:0043087 2 0.010
positive regulation of wound healing GO:0090303 1 0.010
single organism transport GO:0044765 206 0.010
Human Fly
nucleocytoplasmic transport GO:0006913 4 0.010
muscle cell differentiation GO:0042692 139 0.010
negative regulation of wnt signaling pathway GO:0030178 30 0.010
segmentation GO:0035282 97 0.010
signal transduction in absence of ligand GO:0038034 1 0.010
cell migration GO:0016477 237 0.010
regulation of receptor activity GO:0010469 2 0.010
cell cycle GO:0007049 93 0.010

ppt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.060
nervous system disease DOID:863 0 0.029
disease of metabolism DOID:0014667 0 0.017
Human
lipid storage disease DOID:9455 0 0.015
Human
lysosomal storage disease DOID:3211 0 0.015
Human
inherited metabolic disorder DOID:655 0 0.015
Human
musculoskeletal system disease DOID:17 0 0.011
cardiovascular system disease DOID:1287 0 0.011