Danio rerio

0 known processes

prdm9

PR domain containing 9

(Aliases: MGC63970,zgc:63970)

prdm9 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular nitrogen compound biosynthetic process GO:0044271 218 0.717
regulation of transcription dna templated GO:0006355 213 0.534
protein alkylation GO:0008213 13 0.403
regulation of biosynthetic process GO:0009889 250 0.391
macromolecule methylation GO:0043414 19 0.368
histone lysine methylation GO:0034968 12 0.366
histone modification GO:0016570 20 0.366
histone methylation GO:0016571 13 0.363
rna biosynthetic process GO:0032774 181 0.332
chromatin modification GO:0016568 21 0.321
organic cyclic compound biosynthetic process GO:1901362 223 0.301
nucleic acid metabolic process GO:0090304 244 0.300
methylation GO:0032259 22 0.279
cellular biosynthetic process GO:0044249 286 0.268
regulation of gene expression GO:0010468 265 0.248
regulation of macromolecule biosynthetic process GO:0010556 225 0.245
regulation of histone methylation GO:0031060 3 0.239
peptidyl lysine methylation GO:0018022 3 0.239
protein methylation GO:0006479 13 0.231
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.222
nucleobase containing compound metabolic process GO:0006139 274 0.215
nitrogen compound metabolic process GO:0006807 319 0.211
histone h3 k9 methylation GO:0051567 5 0.210
heterocycle metabolic process GO:0046483 290 0.208
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.207
covalent chromatin modification GO:0016569 20 0.204
regulation of macromolecule metabolic process GO:0060255 317 0.203
nucleic acid templated transcription GO:0097659 181 0.200
regulation of nitrogen compound metabolic process GO:0051171 251 0.197
nucleocytoplasmic transport GO:0006913 4 0.185
aromatic compound biosynthetic process GO:0019438 217 0.182
cellular macromolecule metabolic process GO:0044260 391 0.180
organic substance biosynthetic process GO:1901576 289 0.172
transcription dna templated GO:0006351 181 0.172
histone h3 k4 methylation GO:0051568 2 0.169
regulation of cellular metabolic process GO:0031323 320 0.160
regulation of metabolic process GO:0019222 359 0.157
histone h4 k20 methylation GO:0034770 2 0.153
biosynthetic process GO:0009058 294 0.152
negative regulation of cellular process GO:0048523 283 0.151
response to stress GO:0006950 263 0.140
positive regulation of macromolecule metabolic process GO:0010604 93 0.139
regulation of primary metabolic process GO:0080090 311 0.139
macromolecule biosynthetic process GO:0009059 227 0.137
single organism metabolic process GO:0044710 217 0.134
gene expression GO:0010467 252 0.133
cellular protein modification process GO:0006464 100 0.133
nucleobase containing compound biosynthetic process GO:0034654 205 0.126
regulation of nucleic acid templated transcription GO:1903506 213 0.125
regulation of cellular biosynthetic process GO:0031326 245 0.118
meiotic nuclear division GO:0007126 4 0.112
rna metabolic process GO:0016070 219 0.110
cellular protein metabolic process GO:0044267 129 0.110
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.108
nuclear transport GO:0051169 4 0.107
regulation of rna metabolic process GO:0051252 224 0.103
maintenance of location GO:0051235 4 0.101
organic cyclic compound metabolic process GO:1901360 301 0.101
regulation of rna biosynthetic process GO:2001141 213 0.101
heterocycle biosynthetic process GO:0018130 215 0.099
histone h3 k36 methylation GO:0010452 2 0.098
negative regulation of transcription dna templated GO:0045892 45 0.096
cellular macromolecule biosynthetic process GO:0034645 224 0.095
negative regulation of rna metabolic process GO:0051253 48 0.094
negative regulation of nucleic acid templated transcription GO:1903507 45 0.092
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.092
protein metabolic process GO:0019538 183 0.091
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.091
cellular aromatic compound metabolic process GO:0006725 295 0.088
negative regulation of gene expression GO:0010629 65 0.085
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.085
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.083
multicellular organism growth GO:0035264 4 0.082
positive regulation of cellular metabolic process GO:0031325 94 0.082
positive regulation of biosynthetic process GO:0009891 68 0.082
negative regulation of macromolecule metabolic process GO:0010605 76 0.079
protein modification process GO:0036211 100 0.076
peptidyl lysine trimethylation GO:0018023 1 0.075
amine metabolic process GO:0009308 2 0.073
negative regulation of biological process GO:0048519 304 0.073
positive regulation of cellular biosynthetic process GO:0031328 68 0.072
head development GO:0060322 303 0.071
negative regulation of cellular metabolic process GO:0031324 77 0.070
chromosome organization GO:0051276 31 0.068
negative regulation of metabolic process GO:0009892 86 0.067
single organism organelle organization GO:1902589 199 0.061
negative regulation of rna biosynthetic process GO:1902679 45 0.058
positive regulation of cellular process GO:0048522 201 0.058
protein import into nucleus GO:0006606 3 0.058
nuclear import GO:0051170 3 0.057
positive regulation of rna biosynthetic process GO:1902680 57 0.056
single organism nuclear import GO:1902593 3 0.055
cellular response to dna damage stimulus GO:0006974 24 0.052
regulation of establishment of protein localization GO:0070201 4 0.051
positive regulation of map kinase activity GO:0043406 3 0.051
dna metabolic process GO:0006259 27 0.050
positive regulation of transport GO:0051050 2 0.050
cellular amine metabolic process GO:0044106 2 0.050
peptidyl serine phosphorylation GO:0018105 1 0.050
phagocytosis GO:0006909 3 0.049
positive regulation of dna metabolic process GO:0051054 1 0.049
larval development GO:0002164 2 0.049
response to chemical GO:0042221 320 0.048
regulation of multicellular organism growth GO:0040014 4 0.048
establishment of localization GO:0051234 244 0.048
positive regulation of transcription dna templated GO:0045893 57 0.048
negative regulation of cellular biosynthetic process GO:0031327 55 0.046
protein import GO:0017038 3 0.046
skeletal system development GO:0001501 181 0.045
signal transduction GO:0007165 455 0.045
chromatin organization GO:0006325 22 0.045
histone h3 k9 modification GO:0061647 5 0.044
transport GO:0006810 220 0.043
regulation of multicellular organismal process GO:0051239 277 0.043
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.043
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.043
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.042
regulation of response to stimulus GO:0048583 269 0.042
locomotion GO:0040011 313 0.041
macromolecule modification GO:0043412 111 0.041
transcription from rna polymerase ii promoter GO:0006366 80 0.041
protein localization to nucleus GO:0034504 3 0.041
regulation of signal transduction GO:0009966 225 0.039
female gonad development GO:0008585 4 0.038
regulation of meiotic cell cycle GO:0051445 1 0.038
brain development GO:0007420 293 0.038
negative regulation of biosynthetic process GO:0009890 55 0.037
internal peptidyl lysine acetylation GO:0018393 2 0.036
embryo development ending in birth or egg hatching GO:0009792 271 0.036
Worm
modification dependent protein catabolic process GO:0019941 3 0.036
regulation of protein catabolic process GO:0042176 1 0.036
positive regulation of nucleic acid templated transcription GO:1903508 57 0.036
positive regulation of immune effector process GO:0002699 3 0.035
gastrulation GO:0007369 208 0.034
heart development GO:0007507 313 0.034
cellular localization GO:0051641 97 0.033
regulation of developmental process GO:0050793 247 0.033
cognition GO:0050890 1 0.033
cellular ketone metabolic process GO:0042180 11 0.033
cellular response to chemical stimulus GO:0070887 157 0.033
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.032
organelle organization GO:0006996 227 0.032
cellular response to extracellular stimulus GO:0031668 2 0.032
peptidyl lysine dimethylation GO:0018027 1 0.032
internal protein amino acid acetylation GO:0006475 2 0.031
positive regulation of cellular component biogenesis GO:0044089 3 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.031
sensory organ development GO:0007423 393 0.031
sex determination GO:0007530 1 0.030
single organism transport GO:0044765 206 0.030
regulation of cellular ketone metabolic process GO:0010565 7 0.030
cellular amino acid metabolic process GO:0006520 7 0.030
digestive system development GO:0055123 289 0.030
response to nutrient GO:0007584 3 0.030
eye development GO:0001654 277 0.030
positive regulation of biological process GO:0048518 253 0.030
cellular nitrogen compound metabolic process GO:0034641 290 0.029
regulation of stem cell differentiation GO:2000736 4 0.029
cellular response to nutrient levels GO:0031669 2 0.029
positive regulation of jun kinase activity GO:0043507 2 0.028
organic acid metabolic process GO:0006082 31 0.028
positive regulation of muscle organ development GO:0048636 1 0.028
hormone transport GO:0009914 2 0.028
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.027
multi organism process GO:0051704 134 0.027
regulation of protein transport GO:0051223 3 0.027
immune system process GO:0002376 241 0.026
regulation of cellular amine metabolic process GO:0033238 0 0.026
positive regulation of catabolic process GO:0009896 4 0.026
cellular protein catabolic process GO:0044257 4 0.025
positive regulation of cellular amine metabolic process GO:0033240 0 0.025
response to abiotic stimulus GO:0009628 122 0.025
regulation of cell activation GO:0050865 1 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.025
tube morphogenesis GO:0035239 349 0.025
small molecule metabolic process GO:0044281 77 0.024
positive regulation of cell cycle GO:0045787 3 0.024
intracellular signal transduction GO:0035556 85 0.024
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.024
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.024
cellular component morphogenesis GO:0032989 336 0.024
positive regulation of metabolic process GO:0009893 108 0.024
single organism localization GO:1902578 225 0.024
neuron differentiation GO:0030182 353 0.023
lipid storage GO:0019915 1 0.023
regulation of response to extracellular stimulus GO:0032104 1 0.023
connective tissue development GO:0061448 99 0.023
nuclear export GO:0051168 1 0.023
establishment of protein localization to organelle GO:0072594 4 0.023
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.023
proteasomal protein catabolic process GO:0010498 2 0.023
regulation of circadian rhythm GO:0042752 4 0.023
camera type eye development GO:0043010 222 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.022
aging GO:0007568 2 0.022
dna templated transcription initiation GO:0006352 1 0.022
positive regulation of rna metabolic process GO:0051254 59 0.021
regulation of localization GO:0032879 104 0.021
macromolecular complex subunit organization GO:0043933 74 0.021
response to ketone GO:1901654 1 0.021
positive regulation of cell activation GO:0050867 1 0.021
neuron development GO:0048666 262 0.021
chemosensory behavior GO:0007635 1 0.021
hepaticobiliary system development GO:0061008 98 0.021
regulation of type b pancreatic cell development GO:2000074 1 0.021
g2 dna damage checkpoint GO:0031572 3 0.020
cellular component assembly involved in morphogenesis GO:0010927 107 0.020
peptidyl lysine acetylation GO:0018394 2 0.020
response to organic substance GO:0010033 153 0.020
dna alkylation GO:0006305 8 0.020
ubiquitin dependent protein catabolic process GO:0006511 3 0.020
b cell mediated immunity GO:0019724 3 0.020
response to external stimulus GO:0009605 264 0.019
regulation of intracellular protein transport GO:0033157 3 0.019
oxoacid metabolic process GO:0043436 31 0.019
protein acylation GO:0043543 3 0.019
regulation of protein localization to nucleus GO:1900180 2 0.019
positive regulation of cellular catabolic process GO:0031331 3 0.019
regulation of cellular component organization GO:0051128 86 0.019
regulation of organelle assembly GO:1902115 4 0.019
regulation of dna templated transcription elongation GO:0032784 3 0.019
axoneme assembly GO:0035082 9 0.018
response to external biotic stimulus GO:0043207 97 0.018
convergent extension GO:0060026 118 0.018
regulation of cytokine production GO:0001817 3 0.018
dna integrity checkpoint GO:0031570 6 0.018
protein localization GO:0008104 40 0.018
digestive tract morphogenesis GO:0048546 231 0.018
response to drug GO:0042493 3 0.018
double strand break repair GO:0006302 3 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
development of primary female sexual characteristics GO:0046545 4 0.018
negative regulation of cell communication GO:0010648 96 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
cellular response to external stimulus GO:0071496 2 0.017
vasculature development GO:0001944 278 0.017
negative regulation of protein transport GO:0051224 3 0.017
negative regulation of signaling GO:0023057 96 0.017
negative regulation of signal transduction GO:0009968 94 0.017
wnt signaling pathway GO:0016055 80 0.017
developmental growth GO:0048589 166 0.017
regulation of signaling GO:0023051 235 0.017
protein targeting to nucleus GO:0044744 3 0.017
peptide transport GO:0015833 1 0.017
regulation of hormone secretion GO:0046883 2 0.017
liver development GO:0001889 96 0.016
heart morphogenesis GO:0003007 156 0.016
positive regulation of secretion GO:0051047 1 0.016
b cell activation GO:0042113 2 0.016
response to biotic stimulus GO:0009607 97 0.016
hormone secretion GO:0046879 2 0.016
axonogenesis GO:0007409 152 0.016
cell surface receptor signaling pathway GO:0007166 325 0.016
response to other organism GO:0051707 97 0.016
activation of mapk activity GO:0000187 3 0.016
telomere organization GO:0032200 1 0.016
meiosis i GO:0007127 1 0.015
sleep GO:0030431 1 0.015
mitotic dna damage checkpoint GO:0044773 4 0.015
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.015
positive regulation of chromatin modification GO:1903310 1 0.015
neuron projection morphogenesis GO:0048812 161 0.015
cellular response to starvation GO:0009267 1 0.015
negative regulation of cytoplasmic transport GO:1903650 2 0.015
negative regulation of protein phosphorylation GO:0001933 4 0.015
atp catabolic process GO:0006200 4 0.015
positive regulation of stress activated mapk cascade GO:0032874 3 0.015
gamete generation GO:0007276 33 0.015
central nervous system development GO:0007417 387 0.015
cellular response to organic substance GO:0071310 105 0.015
female sex differentiation GO:0046660 4 0.014
regulation of jun kinase activity GO:0043506 3 0.014
negative regulation of response to stimulus GO:0048585 104 0.014
response to bacterium GO:0009617 58 0.014
negative regulation of tor signaling GO:0032007 2 0.014
dna templated transcription elongation GO:0006354 3 0.014
pericardium development GO:0060039 1 0.014
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.014
regulation of dna recombination GO:0000018 2 0.014
immunoglobulin production GO:0002377 1 0.014
establishment of localization in cell GO:0051649 77 0.014
response to glucocorticoid GO:0051384 1 0.014
circadian sleep wake cycle sleep GO:0050802 1 0.014
cell projection morphogenesis GO:0048858 244 0.014
regulation of protein ubiquitination GO:0031396 3 0.014
mitotic dna integrity checkpoint GO:0044774 4 0.014
regulation of organelle organization GO:0033043 29 0.014
positive regulation of leukocyte mediated immunity GO:0002705 1 0.014
positive regulation of muscle tissue development GO:1901863 1 0.013
septum transversum development GO:0003343 4 0.013
golgi vesicle transport GO:0048193 3 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
cellular response to stress GO:0033554 62 0.013
regulation of canonical wnt signaling pathway GO:0060828 34 0.013
macroautophagy GO:0016236 1 0.013
regulation of protein complex assembly GO:0043254 3 0.013
response to hypoxia GO:0001666 25 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
peptidyl serine modification GO:0018209 2 0.013
cell morphogenesis GO:0000902 289 0.013
negative regulation of mapk cascade GO:0043409 4 0.013
hypothalamus cell differentiation GO:0021979 4 0.013
regulation of dna metabolic process GO:0051052 11 0.013
retinal cone cell development GO:0046549 8 0.013
dna catabolic process GO:0006308 1 0.013
cell part morphogenesis GO:0032990 246 0.013
growth GO:0040007 174 0.013
adult behavior GO:0030534 2 0.013
muscle organ development GO:0007517 101 0.013
cellular component assembly GO:0022607 170 0.013
mesenchyme development GO:0060485 127 0.013
generation of neurons GO:0048699 385 0.013
rna localization GO:0006403 4 0.013
dna methylation GO:0006306 8 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
regulation of cell communication GO:0010646 232 0.012
cartilage development GO:0051216 96 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
regulation of synapse organization GO:0050807 3 0.012
protein acetylation GO:0006473 2 0.012
rhythmic process GO:0048511 21 0.012
cell cycle GO:0007049 93 0.012
recombinational repair GO:0000725 1 0.012
regulation of leukocyte mediated immunity GO:0002703 1 0.012
convergent extension involved in axis elongation GO:0060028 26 0.012
pancreas development GO:0031016 84 0.012
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.012
modification dependent macromolecule catabolic process GO:0043632 3 0.012
regulation of tube size GO:0035150 2 0.012
gland development GO:0048732 143 0.012
sexual reproduction GO:0019953 36 0.012
type b pancreatic cell development GO:0003323 4 0.012
blood vessel development GO:0001568 246 0.012
cell matrix adhesion GO:0007160 4 0.012
protein k48 linked ubiquitination GO:0070936 1 0.012
regulation of production of molecular mediator of immune response GO:0002700 1 0.012
organonitrogen compound metabolic process GO:1901564 74 0.012
photoreceptor cell development GO:0042461 40 0.012
somatic cell dna recombination GO:0016444 1 0.011
regionalization GO:0003002 274 0.011
determination of bilateral symmetry GO:0009855 204 0.011
er to golgi vesicle mediated transport GO:0006888 1 0.011
reproduction GO:0000003 40 0.011
nucleoside monophosphate catabolic process GO:0009125 4 0.011
somatic stem cell maintenance GO:0035019 1 0.011
fertilization GO:0009566 3 0.011
nucleic acid transport GO:0050657 2 0.011
cell cycle process GO:0022402 53 0.011
positive regulation of gene expression GO:0010628 71 0.011
double strand break repair via homologous recombination GO:0000724 1 0.011
negative regulation of kinase activity GO:0033673 4 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
response to radiation GO:0009314 51 0.011
reciprocal dna recombination GO:0035825 1 0.011
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.011
regulation of inflammatory response GO:0050727 2 0.011
positive regulation of cytokine production GO:0001819 2 0.011
cellular component biogenesis GO:0044085 178 0.011
regulation of protein targeting GO:1903533 2 0.011
cytokinesis GO:0000910 3 0.011
response to glucose GO:0009749 3 0.011
negative regulation of catabolic process GO:0009895 3 0.011
regulation of dna methylation GO:0044030 5 0.011
bmp signaling pathway GO:0030509 52 0.011
cell aging GO:0007569 2 0.010
meiotic cell cycle process GO:1903046 3 0.010
organic substance transport GO:0071702 58 0.010
positive regulation of protein complex assembly GO:0031334 2 0.010
regulation of protein import into nucleus GO:0042306 2 0.010
positive regulation of striated muscle cell differentiation GO:0051155 1 0.010
regulation of establishment or maintenance of cell polarity GO:0032878 2 0.010
cell cycle g1 s phase transition GO:0044843 1 0.010
cilium organization GO:0044782 71 0.010
positive regulation of multi organism process GO:0043902 3 0.010
g1 s transition of mitotic cell cycle GO:0000082 1 0.010
muscle structure development GO:0061061 196 0.010
mitotic cell cycle embryonic GO:0045448 2 0.010
regulation of chromatin organization GO:1902275 5 0.010

prdm9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.037
disease of cellular proliferation DOID:14566 0 0.025
cancer DOID:162 0 0.020
organ system cancer DOID:0050686 0 0.014
nervous system disease DOID:863 0 0.013