Danio rerio

16 known processes

prox1b

prospero-related homeobox gene 1b

(Aliases: prox3)

prox1b biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
lymph vessel development GO:0001945 27 0.756
vascular endothelial growth factor signaling pathway GO:0038084 3 0.394
regulation of endothelial cell proliferation GO:0001936 1 0.351
endothelial cell proliferation GO:0001935 11 0.348
signal transduction GO:0007165 455 0.305
vasculature development GO:0001944 278 0.294
lymphangiogenesis GO:0001946 25 0.278
regulation of cell communication GO:0010646 232 0.274
cellular component movement GO:0006928 335 0.216
regulation of epithelial cell proliferation GO:0050678 3 0.197
regulation of lymphangiogenesis GO:1901490 4 0.192
cell surface receptor signaling pathway GO:0007166 325 0.176
positive regulation of endothelial cell proliferation GO:0001938 1 0.173
gene expression GO:0010467 252 0.167
blood vessel development GO:0001568 246 0.156
regulation of response to stimulus GO:0048583 269 0.155
lymph vessel morphogenesis GO:0036303 25 0.153
positive regulation of epithelial cell proliferation GO:0050679 1 0.140
heart looping GO:0001947 94 0.137
localization of cell GO:0051674 244 0.128
regulation of multicellular organismal process GO:0051239 277 0.121
cell migration GO:0016477 237 0.104
regulation of rna metabolic process GO:0051252 224 0.102
blood vessel morphogenesis GO:0048514 216 0.100
endocrine process GO:0050886 2 0.099
sprouting angiogenesis GO:0002040 53 0.098
smooth muscle contraction GO:0006939 2 0.093
cell motility GO:0048870 244 0.089
positive regulation of cytokine production GO:0001819 2 0.081
regulation of developmental process GO:0050793 247 0.080
vasculogenesis GO:0001570 41 0.075
neuroblast proliferation GO:0007405 2 0.072
regulation of nucleic acid templated transcription GO:1903506 213 0.070
striated muscle tissue development GO:0014706 110 0.069
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.069
hypothalamus cell differentiation GO:0021979 4 0.068
protein localization to plasma membrane GO:0072659 1 0.067
multi organism process GO:0051704 134 0.067
determination of bilateral symmetry GO:0009855 204 0.066
venous blood vessel morphogenesis GO:0048845 3 0.064
positive regulation of cell cycle GO:0045787 3 0.063
cellular response to vascular endothelial growth factor stimulus GO:0035924 3 0.062
lipid storage GO:0019915 1 0.061
regulation of nitrogen compound metabolic process GO:0051171 251 0.060
phagocytosis GO:0006909 3 0.060
negative regulation of biological process GO:0048519 304 0.058
regulation of signal transduction GO:0009966 225 0.058
positive regulation of biological process GO:0048518 253 0.056
cellular nitrogen compound metabolic process GO:0034641 290 0.056
rna biosynthetic process GO:0032774 181 0.055
detection of mechanical stimulus involved in sensory perception GO:0050974 11 0.054
cellular macromolecule biosynthetic process GO:0034645 224 0.049
regulation of cytokine production GO:0001817 3 0.049
nephron tubule morphogenesis GO:0072078 1 0.048
regulation of anatomical structure morphogenesis GO:0022603 130 0.047
aromatic compound biosynthetic process GO:0019438 217 0.047
regulation of macromolecule metabolic process GO:0060255 317 0.046
carboxylic acid metabolic process GO:0019752 22 0.046
tissue migration GO:0090130 37 0.046
stem cell proliferation GO:0072089 4 0.044
central nervous system development GO:0007417 387 0.044
determination of heart left right asymmetry GO:0061371 117 0.044
regulation of gene expression GO:0010468 265 0.043
negative regulation of secretion GO:0051048 2 0.042
regulation of cell migration GO:0030334 40 0.042
epithelial tube morphogenesis GO:0060562 148 0.041
maintenance of location GO:0051235 4 0.041
locomotion GO:0040011 313 0.040
positive regulation of lymphangiogenesis GO:1901492 3 0.040
positive regulation of transport GO:0051050 2 0.039
positive regulation of cellular process GO:0048522 201 0.038
response to organic substance GO:0010033 153 0.037
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.037
regulation of primary metabolic process GO:0080090 311 0.037
positive regulation of blood circulation GO:1903524 2 0.037
regulation of muscle contraction GO:0006937 3 0.036
cytokinesis GO:0000910 3 0.036
detection of abiotic stimulus GO:0009582 24 0.036
ameboidal type cell migration GO:0001667 143 0.036
regulation of vasculature development GO:1901342 33 0.035
regulation of metabolic process GO:0019222 359 0.035
specification of symmetry GO:0009799 204 0.035
amino acid transport GO:0006865 2 0.035
artery development GO:0060840 22 0.034
embryonic heart tube morphogenesis GO:0003143 108 0.034
rna metabolic process GO:0016070 219 0.033
organic cyclic compound biosynthetic process GO:1901362 223 0.033
protein metabolic process GO:0019538 183 0.032
signal transduction in absence of ligand GO:0038034 1 0.032
regulation of synaptic plasticity GO:0048167 1 0.032
phosphate containing compound metabolic process GO:0006796 108 0.032
phosphorus metabolic process GO:0006793 109 0.032
regulation of signaling GO:0023051 235 0.031
venous blood vessel development GO:0060841 9 0.031
angiogenesis GO:0001525 158 0.031
heterocycle biosynthetic process GO:0018130 215 0.031
cellular amine metabolic process GO:0044106 2 0.031
tube morphogenesis GO:0035239 349 0.031
single organism biosynthetic process GO:0044711 71 0.031
sympathetic nervous system development GO:0048485 3 0.030
cell morphogenesis GO:0000902 289 0.030
regulation of cellular amino acid metabolic process GO:0006521 0 0.030
positive regulation of secretion GO:0051047 1 0.030
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.030
mesenchymal cell development GO:0014031 78 0.030
positive regulation of secretion by cell GO:1903532 1 0.029
heart development GO:0007507 313 0.029
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.029
ras protein signal transduction GO:0007265 7 0.029
notch signaling pathway GO:0007219 35 0.028
positive regulation of epithelial cell migration GO:0010634 2 0.028
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.028
regulation of locomotion GO:0040012 55 0.028
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.028
negative regulation of secretion by cell GO:1903531 2 0.028
negative regulation of sequestering of calcium ion GO:0051283 4 0.028
phosphatidylinositol mediated signaling GO:0048015 2 0.028
negative chemotaxis GO:0050919 1 0.027
oxoacid metabolic process GO:0043436 31 0.027
determination of left right symmetry GO:0007368 179 0.027
regulation of stem cell differentiation GO:2000736 4 0.027
hypothalamus development GO:0021854 14 0.027
skeletal system development GO:0001501 181 0.027
regulation of localization GO:0032879 104 0.027
organic acid metabolic process GO:0006082 31 0.026
regulation of neural precursor cell proliferation GO:2000177 3 0.026
protein processing GO:0016485 12 0.026
regulation of angiogenesis GO:0045765 26 0.026
biosynthetic process GO:0009058 294 0.026
regulation of neurological system process GO:0031644 2 0.026
outflow tract morphogenesis GO:0003151 1 0.026
epithelium migration GO:0090132 25 0.026
canonical wnt signaling pathway GO:0060070 48 0.025
negative regulation of gene expression GO:0010629 65 0.025
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.025
response to external stimulus GO:0009605 264 0.025
negative regulation of multicellular organismal process GO:0051241 69 0.025
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.024
nitrogen compound metabolic process GO:0006807 319 0.024
regulation of retina development in camera type eye GO:1902866 2 0.024
sympathetic ganglion development GO:0061549 2 0.024
regulation of blood vessel size GO:0050880 2 0.024
cellular macromolecule metabolic process GO:0044260 391 0.024
cellular response to radiation GO:0071478 4 0.024
inositol lipid mediated signaling GO:0048017 2 0.023
positive regulation of neural precursor cell proliferation GO:2000179 1 0.023
cranial ganglion development GO:0061550 3 0.023
detection of stimulus involved in sensory perception GO:0050906 21 0.023
protein localization to nucleus GO:0034504 3 0.023
embryonic organ morphogenesis GO:0048562 274 0.023
exocytosis GO:0006887 1 0.023
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.023
regulation of stem cell proliferation GO:0072091 2 0.023
calcium ion homeostasis GO:0055074 19 0.023
negative regulation of protein transport GO:0051224 3 0.023
ion transmembrane transport GO:0034220 91 0.022
maternal determination of anterior posterior axis embryo GO:0008358 4 0.022
head development GO:0060322 303 0.022
regulation of endocrine process GO:0044060 2 0.022
regulation of fatty acid metabolic process GO:0019217 1 0.022
regulation of cell motility GO:2000145 46 0.022
positive regulation of map kinase activity GO:0043406 3 0.022
anterior posterior pattern specification GO:0009952 152 0.022
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.022
regulation of cellular ketone metabolic process GO:0010565 7 0.022
single organism metabolic process GO:0044710 217 0.022
positive regulation of rna metabolic process GO:0051254 59 0.021
response to other organism GO:0051707 97 0.021
neuron development GO:0048666 262 0.021
regulation of erythrocyte differentiation GO:0045646 2 0.021
skeletal muscle organ development GO:0060538 78 0.021
stem cell development GO:0048864 82 0.021
cellular nitrogen compound biosynthetic process GO:0044271 218 0.021
sensory perception of chemical stimulus GO:0007606 3 0.021
diencephalon development GO:0021536 58 0.021
synaptic target recognition GO:0008039 1 0.021
transport GO:0006810 220 0.020
cellular aromatic compound metabolic process GO:0006725 295 0.020
g protein coupled receptor signaling pathway GO:0007186 74 0.020
single organism localization GO:1902578 225 0.020
enzyme linked receptor protein signaling pathway GO:0007167 106 0.020
regulation of sequestering of calcium ion GO:0051282 4 0.020
dna templated transcription initiation GO:0006352 1 0.020
neuron neuron synaptic transmission GO:0007270 1 0.020
response to abiotic stimulus GO:0009628 122 0.020
regulation of establishment of protein localization GO:0070201 4 0.020
regulation of protein transport GO:0051223 3 0.020
cognition GO:0050890 1 0.020
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.020
nucleic acid metabolic process GO:0090304 244 0.020
regulation of binding GO:0051098 3 0.020
mitochondrion organization GO:0007005 4 0.020
regulation of protein binding GO:0043393 3 0.020
regulation of oligodendrocyte differentiation GO:0048713 1 0.019
pigmentation GO:0043473 85 0.019
positive regulation of stress activated mapk cascade GO:0032874 3 0.019
regulation of cell shape GO:0008360 1 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
multicellular organismal macromolecule metabolic process GO:0044259 2 0.019
organic substance biosynthetic process GO:1901576 289 0.019
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.019
response to estrogen GO:0043627 27 0.019
cellular protein modification process GO:0006464 100 0.019
phagocytosis engulfment GO:0006911 1 0.019
stem cell division GO:0017145 1 0.019
amine metabolic process GO:0009308 2 0.019
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.019
pole plasm assembly GO:0007315 4 0.019
locomotory behavior GO:0007626 34 0.019
detection of stimulus GO:0051606 29 0.018
positive regulation of multicellular organismal process GO:0051240 52 0.018
regulation of tube size GO:0035150 2 0.018
stem cell differentiation GO:0048863 117 0.018
heterocycle metabolic process GO:0046483 290 0.018
regulation of multicellular organismal development GO:2000026 223 0.018
leukocyte homeostasis GO:0001776 2 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
positive regulation of rna biosynthetic process GO:1902680 57 0.018
positive regulation of macromolecule metabolic process GO:0010604 93 0.018
regulation of protein catabolic process GO:0042176 1 0.018
neuron projection guidance GO:0097485 86 0.018
modification dependent macromolecule catabolic process GO:0043632 3 0.018
neural crest cell development GO:0014032 62 0.018
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.018
negative regulation of cellular biosynthetic process GO:0031327 55 0.018
regulation of dendrite development GO:0050773 3 0.018
detection of mechanical stimulus GO:0050982 11 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
epithelial cell differentiation GO:0030855 116 0.017
cellular component morphogenesis GO:0032989 336 0.017
nucleobase containing compound metabolic process GO:0006139 274 0.017
locomotor rhythm GO:0045475 3 0.017
ubiquitin dependent protein catabolic process GO:0006511 3 0.017
response to chemical GO:0042221 320 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
regulation of cell substrate adhesion GO:0010810 1 0.017
positive regulation of leukocyte differentiation GO:1902107 1 0.017
adherens junction organization GO:0034332 4 0.017
cell part morphogenesis GO:0032990 246 0.017
zymogen activation GO:0031638 3 0.017
transcription dna templated GO:0006351 181 0.017
cytoplasm organization GO:0007028 4 0.017
morphogenesis of an epithelium GO:0002009 333 0.017
release of sequestered calcium ion into cytosol GO:0051209 3 0.017
glial cell differentiation GO:0010001 42 0.017
regulation of systemic arterial blood pressure GO:0003073 1 0.016
positive regulation of endothelial cell migration GO:0010595 2 0.016
artery morphogenesis GO:0048844 14 0.016
cell morphogenesis involved in differentiation GO:0000904 195 0.016
lymphatic endothelial cell differentiation GO:0060836 1 0.016
nucleotide biosynthetic process GO:0009165 21 0.016
positive regulation of cytoskeleton organization GO:0051495 3 0.016
positive regulation of catabolic process GO:0009896 4 0.016
aorta development GO:0035904 4 0.016
cellular ketone metabolic process GO:0042180 11 0.016
positive regulation of nucleic acid templated transcription GO:1903508 57 0.016
positive regulation of apoptotic signaling pathway GO:2001235 1 0.016
blood circulation GO:0008015 87 0.016
fertilization GO:0009566 3 0.016
regulation of dendrite morphogenesis GO:0048814 3 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
dicarboxylic acid transport GO:0006835 1 0.016
regulation of endothelial cell differentiation GO:0045601 3 0.016
cell cycle arrest GO:0007050 1 0.016
cardiac cell fate commitment GO:0060911 1 0.015
aorta morphogenesis GO:0035909 3 0.015
cellular protein catabolic process GO:0044257 4 0.015
negative regulation of stem cell differentiation GO:2000737 2 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.015
tissue remodeling GO:0048771 4 0.015
intracellular signal transduction GO:0035556 85 0.015
nitrogen compound transport GO:0071705 23 0.015
positive regulation of cell division GO:0051781 2 0.015
antimicrobial humoral response GO:0019730 2 0.015
cell projection morphogenesis GO:0048858 244 0.015
lateral inhibition GO:0046331 1 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
ovulation cycle process GO:0022602 2 0.015
stem cell maintenance GO:0019827 4 0.015
neural crest cell migration GO:0001755 42 0.015
regulation of reproductive process GO:2000241 4 0.015
positive regulation of myeloid cell differentiation GO:0045639 2 0.015
limbic system development GO:0021761 16 0.015
retina development in camera type eye GO:0060041 146 0.015
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
detection of mechanical stimulus involved in sensory perception of sound GO:0050910 3 0.014
camera type eye development GO:0043010 222 0.014
regulation of cellular component movement GO:0051270 55 0.014
positive regulation of jnk cascade GO:0046330 3 0.014
regulation of biosynthetic process GO:0009889 250 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
transcription from rna polymerase ii promoter GO:0006366 80 0.014
regulation of blood pressure GO:0008217 1 0.014
endothelial cell fate commitment GO:0060839 3 0.014
chemosensory behavior GO:0007635 1 0.014
regulation of organelle assembly GO:1902115 4 0.014
organic cyclic compound metabolic process GO:1901360 301 0.014
cell cycle GO:0007049 93 0.014
erk1 and erk2 cascade GO:0070371 4 0.014
protein secretion GO:0009306 1 0.014
negative regulation of rna metabolic process GO:0051253 48 0.014
cellular response to chemical stimulus GO:0070887 157 0.014
microtubule organizing center organization GO:0031023 1 0.014
convergent extension involved in gastrulation GO:0060027 71 0.013
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
cell proliferation GO:0008283 80 0.013
circulatory system process GO:0003013 87 0.013
regulation of hormone secretion GO:0046883 2 0.013
negative regulation of cellular process GO:0048523 283 0.013
regulation of rna biosynthetic process GO:2001141 213 0.013
positive regulation of signal transduction GO:0009967 56 0.013
neuromuscular process controlling balance GO:0050885 3 0.013
macromolecule biosynthetic process GO:0009059 227 0.013
regulation of myotube differentiation GO:0010830 2 0.013
definitive hemopoiesis GO:0060216 18 0.013
larval development GO:0002164 2 0.013
sensory perception of smell GO:0007608 2 0.013
autonomic nervous system development GO:0048483 19 0.013
cellular biosynthetic process GO:0044249 286 0.013
sensory neuron axon guidance GO:0097374 3 0.013
mesenchyme development GO:0060485 127 0.013
mesenchymal cell differentiation GO:0048762 87 0.013
interspecies interaction between organisms GO:0044419 4 0.012
positive regulation of cell communication GO:0010647 56 0.012
neuroepithelial cell differentiation GO:0060563 26 0.012
regulation of molecular function GO:0065009 70 0.012
organ formation GO:0048645 17 0.012
catechol containing compound metabolic process GO:0009712 2 0.012
membrane invagination GO:0010324 1 0.012
carbohydrate derivative biosynthetic process GO:1901137 43 0.012
sensory organ development GO:0007423 393 0.012
regulation of neural retina development GO:0061074 2 0.012
system process GO:0003008 185 0.012
myeloid leukocyte differentiation GO:0002573 15 0.012
regulation of cellular biosynthetic process GO:0031326 245 0.012
positive regulation of gene expression GO:0010628 71 0.012
positive regulation of leukocyte chemotaxis GO:0002690 1 0.012
viral process GO:0016032 1 0.012
homeostatic process GO:0042592 142 0.012
nucleic acid templated transcription GO:0097659 181 0.012
regulation of macromolecule biosynthetic process GO:0010556 225 0.012
organic substance transport GO:0071702 58 0.012
brain development GO:0007420 293 0.012
organelle organization GO:0006996 227 0.012
nephron morphogenesis GO:0072028 2 0.012
homeostasis of number of cells within a tissue GO:0048873 4 0.012
negative regulation of biosynthetic process GO:0009890 55 0.012
regulation of autophagy GO:0010506 3 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
positive regulation of epithelial cell differentiation GO:0030858 2 0.012
developmental programmed cell death GO:0010623 4 0.012
positive regulation of stem cell proliferation GO:2000648 1 0.011
positive regulation of transcription dna templated GO:0045893 57 0.011
interaction with host GO:0051701 4 0.011
cytosolic calcium ion transport GO:0060401 3 0.011
regulation of intracellular signal transduction GO:1902531 57 0.011
autophagy GO:0006914 4 0.011
ovulation cycle GO:0042698 2 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
heart morphogenesis GO:0003007 156 0.011
organic acid transport GO:0015849 9 0.011
response to wounding GO:0009611 116 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
endothelial cell differentiation GO:0045446 20 0.011
sequestering of calcium ion GO:0051208 3 0.011
embryonic heart tube development GO:0035050 133 0.011
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
regulation of cell differentiation GO:0045595 142 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
negative regulation of cellular component movement GO:0051271 18 0.011
monocyte differentiation GO:0030224 2 0.011
homeostasis of number of cells GO:0048872 62 0.011
negative regulation of kinase activity GO:0033673 4 0.011
response to light stimulus GO:0009416 46 0.011
positive regulation of histone modification GO:0031058 1 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
regulation of phosphorus metabolic process GO:0051174 43 0.011
cell recognition GO:0008037 19 0.011
heart formation GO:0060914 13 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
developmental pigmentation GO:0048066 48 0.011
immune system process GO:0002376 241 0.011
i kappab kinase nf kappab signaling GO:0007249 4 0.011
protein import into nucleus GO:0006606 3 0.011
macromolecule modification GO:0043412 111 0.011
renal system process GO:0003014 14 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.010
cellular response to molecule of bacterial origin GO:0071219 3 0.010
leukocyte proliferation GO:0070661 1 0.010
response to external biotic stimulus GO:0043207 97 0.010
cardioblast migration GO:0003260 7 0.010
glucose import GO:0046323 2 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.010
ribose phosphate biosynthetic process GO:0046390 20 0.010
lytic vacuole organization GO:0080171 1 0.010
regulation of calcium mediated signaling GO:0050848 1 0.010
regulation of coagulation GO:0050818 2 0.010
regulation of synapse assembly GO:0051963 3 0.010
regulation of wound healing GO:0061041 2 0.010
metal ion homeostasis GO:0055065 26 0.010
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.010
positive regulation of rho protein signal transduction GO:0035025 0 0.010
septum transversum development GO:0003343 4 0.010
regulation of exocytosis GO:0017157 1 0.010
regulation of rho protein signal transduction GO:0035023 2 0.010
multicellular organism growth GO:0035264 4 0.010

prox1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.018
disease of metabolism DOID:0014667 0 0.013