Danio rerio

68 known processes

ptch1

patched 1

(Aliases: lep,ptc1,ptc2)

ptch1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
skeletal system development GO:0001501 181 0.995
cellular component movement GO:0006928 335 0.990
Zebrafish Fly
cell surface receptor signaling pathway GO:0007166 325 0.980
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.974
heart jogging GO:0003146 40 0.961
embryonic organ development GO:0048568 381 0.959
Mouse
limb bud formation GO:0060174 2 0.951
multi organism reproductive process GO:0044703 36 0.949
Worm Fly
retina development in camera type eye GO:0060041 146 0.938
odontogenesis of dentin containing tooth GO:0042475 1 0.935
fin morphogenesis GO:0033334 53 0.934
sensory organ morphogenesis GO:0090596 200 0.925
direct ossification GO:0036072 3 0.925
bmp signaling pathway involved in heart jogging GO:0003303 14 0.911
bmp signaling pathway involved in heart development GO:0061312 15 0.887
sensory organ development GO:0007423 393 0.878
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.875
regulation of multicellular organismal process GO:0051239 277 0.874
sexual reproduction GO:0019953 36 0.864
Worm Fly
generation of neurons GO:0048699 385 0.856
Zebrafish Mouse Fly
regulation of signal transduction GO:0009966 225 0.837
embryo development ending in birth or egg hatching GO:0009792 271 0.825
Mouse Worm
homeostatic process GO:0042592 142 0.813
Mouse Fly
appendage development GO:0048736 80 0.786
Mouse Fly
digestive system development GO:0055123 289 0.783
chordate embryonic development GO:0043009 271 0.783
Mouse
digestive tract development GO:0048565 265 0.780
intramembranous ossification GO:0001957 3 0.764
cardiac endothelial cell differentiation GO:0003348 5 0.759
larval development GO:0002164 2 0.749
Worm
heart development GO:0007507 313 0.730
fin development GO:0033333 77 0.729
regionalization GO:0003002 274 0.716
Zebrafish Mouse
eye morphogenesis GO:0048592 144 0.713
camera type eye development GO:0043010 222 0.705
floor plate formation GO:0021508 12 0.701
skeletal system morphogenesis GO:0048705 102 0.700
appendage morphogenesis GO:0035107 56 0.695
Mouse Fly
somitogenesis GO:0001756 87 0.693
post embryonic foregut morphogenesis GO:0048618 3 0.692
system process GO:0003008 185 0.684
inner ear development GO:0048839 126 0.681
hindbrain development GO:0030902 91 0.676
mesodermal cell migration GO:0008078 12 0.675
mesoderm development GO:0007498 88 0.660
extracellular matrix assembly GO:0085029 1 0.659
regulation of biological quality GO:0065008 263 0.631
Mouse Worm Fly
endocardium development GO:0003157 9 0.630
embryonic pectoral fin morphogenesis GO:0035118 24 0.629
cell motility GO:0048870 244 0.624
Fly
locomotion GO:0040011 313 0.604
Zebrafish Worm Fly
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.594
bmp signaling pathway involved in determination of left right symmetry GO:0003154 14 0.591
digestive tract morphogenesis GO:0048546 231 0.589
organelle organization GO:0006996 227 0.583
localization of cell GO:0051674 244 0.582
Fly
glial cell fate specification GO:0021780 4 0.579
multicellular organism reproduction GO:0032504 35 0.568
Worm Fly
atrial ventricular junction remodeling GO:0003294 2 0.565
heart valve morphogenesis GO:0003179 8 0.565
embryonic skeletal system morphogenesis GO:0048704 93 0.565
myotube differentiation GO:0014902 45 0.556
embryonic digestive tract morphogenesis GO:0048557 3 0.542
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.538
muscle organ development GO:0007517 101 0.536
regulation of localization GO:0032879 104 0.536
Mouse Fly
periodic partitioning GO:0007365 1 0.532
positive regulation of stem cell proliferation GO:2000648 1 0.530
regulation of mesenchymal cell proliferation GO:0010464 1 0.523
retina morphogenesis in camera type eye GO:0060042 79 0.520
regulation of protein maturation GO:1903317 10 0.512
embryonic digestive tract development GO:0048566 4 0.512
oligodendrocyte cell fate specification GO:0021778 4 0.508
cellular response to growth factor stimulus GO:0071363 39 0.506
specification of symmetry GO:0009799 204 0.493
embryonic organ morphogenesis GO:0048562 274 0.491
foregut morphogenesis GO:0007440 4 0.488
axial mesoderm formation GO:0048320 4 0.484
embryonic skeletal system development GO:0048706 97 0.477
retina homeostasis GO:0001895 12 0.477
mesenchyme development GO:0060485 127 0.475
multicellular organismal reproductive process GO:0048609 35 0.470
Worm Fly
somite development GO:0061053 96 0.469
Mouse
proximal distal pattern formation GO:0009954 1 0.466
Zebrafish
invagination involved in gastrulation with mouth forming second GO:0055109 1 0.466
cardiocyte differentiation GO:0035051 44 0.465
aromatic compound biosynthetic process GO:0019438 217 0.463
mesoderm morphogenesis GO:0048332 51 0.457
connective tissue development GO:0061448 99 0.457
tissue remodeling GO:0048771 4 0.454
cardioblast differentiation GO:0010002 9 0.450
signal transduction downstream of smoothened GO:0007227 1 0.448
spemann organizer formation at the embryonic shield GO:0060063 2 0.445
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.442
cartilage development GO:0051216 96 0.440
embryonic viscerocranium morphogenesis GO:0048703 52 0.439
cardiac atrium morphogenesis GO:0003209 2 0.425
determination of bilateral symmetry GO:0009855 204 0.422
macromolecule biosynthetic process GO:0009059 227 0.421
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.404
multi organism process GO:0051704 134 0.403
Worm Fly
floor plate morphogenesis GO:0033505 12 0.401
gamete generation GO:0007276 33 0.397
Worm Fly
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.396
cell projection morphogenesis GO:0048858 244 0.392
Zebrafish Fly
epithelial structure maintenance GO:0010669 8 0.388
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.381
endocrine system development GO:0035270 65 0.380
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.379
atrioventricular valve formation GO:0003190 3 0.371
response to chemical GO:0042221 320 0.370
Zebrafish Mouse Fly
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.368
positive regulation of signaling GO:0023056 56 0.367
cell differentiation in spinal cord GO:0021515 40 0.365
Mouse
anterior posterior pattern specification GO:0009952 152 0.365
cellular response to chemical stimulus GO:0070887 157 0.359
Mouse
segmentation GO:0035282 97 0.353
regulation of biosynthetic process GO:0009889 250 0.352
mesenchymal cell proliferation GO:0010463 1 0.351
negative regulation of oocyte development GO:0060283 2 0.348
cartilage condensation GO:0001502 3 0.342
negative regulation of cellular process GO:0048523 283 0.339
developmental process involved in reproduction GO:0003006 27 0.339
Worm Fly
cell morphogenesis involved in differentiation GO:0000904 195 0.338
Zebrafish Fly
single organism reproductive process GO:0044702 40 0.338
Worm Fly
segment polarity determination GO:0007367 1 0.337
auditory receptor cell fate commitment GO:0009912 4 0.333
chemical homeostasis GO:0048878 49 0.331
Mouse Fly
embryonic camera type eye development GO:0031076 29 0.327
eye development GO:0001654 277 0.325
adrenal gland development GO:0030325 10 0.322
regulation of primary metabolic process GO:0080090 311 0.321
bmp signaling pathway GO:0030509 52 0.318
heart valve formation GO:0003188 4 0.316
forebrain regionalization GO:0021871 4 0.306
muscle structure development GO:0061061 196 0.301
septum transversum development GO:0003343 4 0.296
kidney development GO:0001822 92 0.291
Mouse
muscle tissue development GO:0060537 110 0.289
multicellular organismal homeostasis GO:0048871 29 0.286
atrioventricular valve morphogenesis GO:0003181 6 0.286
swim bladder development GO:0048794 19 0.282
cell fate specification GO:0001708 68 0.280
ventral spinal cord interneuron specification GO:0021521 3 0.279
caudal fin morphogenesis GO:0035143 7 0.279
myotube cell development GO:0014904 35 0.273
cell migration involved in gastrulation GO:0042074 79 0.269
tube morphogenesis GO:0035239 349 0.269
Mouse
intermediate mesoderm development GO:0048389 2 0.266
enzyme linked receptor protein signaling pathway GO:0007167 106 0.259
specification of organ position GO:0010159 3 0.253
regulation of behavior GO:0050795 24 0.252
regulation of cell communication GO:0010646 232 0.252
positive regulation of response to stimulus GO:0048584 80 0.250
gastrulation GO:0007369 208 0.247
determination of heart left right asymmetry GO:0061371 117 0.246
ventral spinal cord interneuron fate commitment GO:0060579 3 0.246
hematopoietic stem cell differentiation GO:0060218 20 0.239
stem cell proliferation GO:0072089 4 0.238
central nervous system development GO:0007417 387 0.238
Mouse
regulation of organ growth GO:0046620 3 0.236
endocardial cell differentiation GO:0060956 5 0.233
muscle cell fate specification GO:0042694 5 0.232
endodermal digestive tract morphogenesis GO:0061031 2 0.226
pectoral fin development GO:0033339 50 0.225
epithelial cell differentiation GO:0030855 116 0.222
Mouse
hemopoiesis GO:0030097 183 0.218
endocardial cushion formation GO:0003272 2 0.218
positive regulation of gene expression GO:0010628 71 0.217
regulation of response to stimulus GO:0048583 269 0.217
regulation of establishment of protein localization GO:0070201 4 0.216
Fly
regulation of system process GO:0044057 40 0.216
retinal pigment epithelium development GO:0003406 8 0.213
pancreas development GO:0031016 84 0.213
developmental growth GO:0048589 166 0.211
Mouse Worm
ear development GO:0043583 127 0.209
heart valve development GO:0003170 14 0.207
cell proliferation involved in heart morphogenesis GO:0061323 2 0.205
photoreceptor cell fate commitment GO:0046552 1 0.204
negative regulation of muscle organ development GO:0048635 5 0.201
single organism localization GO:1902578 225 0.200
Fly
medial fin development GO:0033338 16 0.199
positive regulation of cell proliferation GO:0008284 15 0.198
cell cycle GO:0007049 93 0.196
Mouse Fly
embryonic heart tube morphogenesis GO:0003143 108 0.196
blood vessel endothelial cell differentiation GO:0060837 2 0.195
striated muscle cell differentiation GO:0051146 129 0.193
positive regulation of muscle tissue development GO:1901863 1 0.193
adenohypophysis development GO:0021984 15 0.190
signal transduction GO:0007165 455 0.190
canonical wnt signaling pathway GO:0060070 48 0.189
muscle cell fate determination GO:0007521 1 0.188
regulation of multicellular organismal development GO:2000026 223 0.186
regulation of multicellular organism growth GO:0040014 4 0.184
Mouse Worm
muscle cell differentiation GO:0042692 139 0.184
positive regulation of skeletal muscle tissue development GO:0048643 1 0.182
regulation of reproductive process GO:2000241 4 0.181
embryonic skeletal joint development GO:0072498 3 0.180
regulation of oligodendrocyte differentiation GO:0048713 1 0.176
camera type eye photoreceptor cell differentiation GO:0060219 19 0.175
transcription from rna polymerase ii promoter GO:0006366 80 0.173
tissue homeostasis GO:0001894 25 0.173
neuron development GO:0048666 262 0.171
Zebrafish Fly
neuron fate specification GO:0048665 20 0.170
notochord development GO:0030903 54 0.170
lipid homeostasis GO:0055088 3 0.170
Fly
head development GO:0060322 303 0.169
Mouse
skeletal muscle fiber development GO:0048741 35 0.169
regulation of cellular biosynthetic process GO:0031326 245 0.168
fin regeneration GO:0031101 51 0.166
pigment cell differentiation GO:0050931 38 0.165
nephron tubule morphogenesis GO:0072078 1 0.165
Mouse
wound healing GO:0042060 90 0.164
positive regulation of muscle organ development GO:0048636 1 0.164
heart looping GO:0001947 94 0.163
cellular macromolecule metabolic process GO:0044260 391 0.162
regulation of protein processing GO:0070613 10 0.160
lateral line system development GO:0048925 76 0.159
apoptotic process GO:0006915 116 0.157
Fly
positive regulation of rna metabolic process GO:0051254 59 0.155
heart morphogenesis GO:0003007 156 0.152
Mouse
tube formation GO:0035148 25 0.152
Mouse
positive regulation of cell cycle GO:0045787 3 0.152
caudal fin development GO:0033336 9 0.152
reproductive process GO:0022414 40 0.151
Worm Fly
spinal cord motor neuron differentiation GO:0021522 26 0.151
Mouse
hematopoietic or lymphoid organ development GO:0048534 191 0.151
neuron differentiation GO:0030182 353 0.151
Zebrafish Mouse Fly
odontogenesis GO:0042476 9 0.150
response to external stimulus GO:0009605 264 0.147
Zebrafish Fly
vagus nerve development GO:0021564 2 0.146
embryonic neurocranium morphogenesis GO:0048702 15 0.144
endocardium formation GO:0060214 1 0.144
developmental pigmentation GO:0048066 48 0.144
cell migration GO:0016477 237 0.143
Fly
proepicardium development GO:0003342 4 0.143
regulation of metabolic process GO:0019222 359 0.142
catecholamine biosynthetic process GO:0042423 2 0.140
auditory receptor cell differentiation GO:0042491 15 0.139
embryonic cranial skeleton morphogenesis GO:0048701 90 0.139
behavior GO:0007610 74 0.138
Worm
protein metabolic process GO:0019538 183 0.138
Mouse
regulation of cell differentiation GO:0045595 142 0.137
nitrogen compound metabolic process GO:0006807 319 0.137
regulation of dna replication GO:0006275 3 0.137
somatic motor neuron differentiation GO:0021523 5 0.136
aorta development GO:0035904 4 0.136
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.135
embryonic limb morphogenesis GO:0030326 2 0.132
Mouse
cellular component biogenesis GO:0044085 178 0.132
diencephalon development GO:0021536 58 0.132
ventral spinal cord development GO:0021517 35 0.130
Mouse
specification of organ identity GO:0010092 2 0.130
photoreceptor cell maintenance GO:0045494 11 0.128
stem cell differentiation GO:0048863 117 0.128
exocrine pancreas development GO:0031017 28 0.127
regulation of macromolecule metabolic process GO:0060255 317 0.125
camera type eye morphogenesis GO:0048593 108 0.124
positive regulation of transcription dna templated GO:0045893 57 0.124
endocrine pancreas development GO:0031018 27 0.123
inner ear receptor cell development GO:0060119 20 0.122
regulation of locomotion GO:0040012 55 0.120
Fly
regulation of organ morphogenesis GO:2000027 35 0.119
neural plate development GO:0001840 10 0.118
Mouse
embryonic appendage morphogenesis GO:0035113 30 0.118
Mouse
sprouting angiogenesis GO:0002040 53 0.118
regulation of embryonic development GO:0045995 47 0.116
blood vessel morphogenesis GO:0048514 216 0.115
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.115
regulation of cellular response to growth factor stimulus GO:0090287 35 0.114
regulation of wnt signaling pathway calcium modulating pathway GO:0008591 3 0.113
maintenance of location GO:0051235 4 0.112
Worm
negative regulation of cellular catabolic process GO:0031330 3 0.110
heart contraction GO:0060047 71 0.110
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.110
negative regulation of cell communication GO:0010648 96 0.109
epidermis development GO:0008544 48 0.109
Mouse
swim bladder morphogenesis GO:0048795 4 0.109
embryonic pattern specification GO:0009880 44 0.109
Mouse
optic placode formation involved in camera type eye formation GO:0046619 3 0.108
aging GO:0007568 2 0.107
determination of left right symmetry GO:0007368 179 0.107
tissue regeneration GO:0042246 74 0.107
cardiac ventricle formation GO:0003211 1 0.105
ear morphogenesis GO:0042471 64 0.105
regulation of endodermal cell fate specification GO:0042663 15 0.105
regulation of heart morphogenesis GO:2000826 17 0.105
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 15 0.104
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.104
regulation of cell proliferation involved in tissue homeostasis GO:0060784 2 0.103
blood vessel development GO:0001568 246 0.103
protein localization to nucleus GO:0034504 3 0.103
Fly
cellular aromatic compound metabolic process GO:0006725 295 0.102
pituitary gland development GO:0021983 16 0.101
positive regulation of mesodermal cell fate specification GO:0048337 1 0.101
epithelial cell morphogenesis GO:0003382 2 0.101
cell proliferation in dorsal spinal cord GO:0010456 2 0.100
regulation of molecular function GO:0065009 70 0.100
intestinal epithelial cell differentiation GO:0060575 3 0.100
brain development GO:0007420 293 0.098
Mouse
endocardial cushion development GO:0003197 6 0.097
embryonic heart tube formation GO:0003144 1 0.096
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.095
regulation of epithelial to mesenchymal transition GO:0010717 3 0.095
organic cyclic compound biosynthetic process GO:1901362 223 0.095
single organism metabolic process GO:0044710 217 0.094
reproduction GO:0000003 40 0.093
Worm Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.092
regulation of anatomical structure morphogenesis GO:0022603 130 0.092
embryonic heart tube development GO:0035050 133 0.092
cellular macromolecule biosynthetic process GO:0034645 224 0.091
endocardium morphogenesis GO:0003160 4 0.091
cell morphogenesis GO:0000902 289 0.091
Zebrafish Fly
growth GO:0040007 174 0.091
Mouse Worm
glomerulus vasculature development GO:0072012 2 0.090
cardiogenic plate morphogenesis GO:0003142 1 0.090
semicircular canal development GO:0060872 24 0.089
biosynthetic process GO:0009058 294 0.089
neural plate morphogenesis GO:0001839 7 0.089
otic vesicle development GO:0071599 42 0.088
nucleobase containing compound metabolic process GO:0006139 274 0.088
wnt signaling pathway GO:0016055 80 0.088
negative regulation of protein processing GO:0010955 10 0.088
positive regulation of muscle cell differentiation GO:0051149 1 0.087
cartilage morphogenesis GO:0060536 13 0.086
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.085
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.084
morphogenesis of embryonic epithelium GO:0016331 30 0.083
Mouse
extracellular matrix organization GO:0030198 27 0.082
specification of axis polarity GO:0065001 4 0.082
regulation of nucleocytoplasmic transport GO:0046822 2 0.081
Fly
regulation of smoothened signaling pathway GO:0008589 18 0.080
taxis GO:0042330 109 0.080
Zebrafish Fly
organic substance biosynthetic process GO:1901576 289 0.080
auditory receptor cell fate determination GO:0042668 2 0.080
atrioventricular valve development GO:0003171 11 0.080
muscle cell fate commitment GO:0042693 9 0.080
regulation of wnt signaling pathway GO:0030111 53 0.079
homeostasis of number of cells within a tissue GO:0048873 4 0.079
dna templated transcription elongation GO:0006354 3 0.079
regeneration GO:0031099 91 0.079
regulation of stem cell proliferation GO:0072091 2 0.079
single organism cell adhesion GO:0098602 29 0.078
cell cell signaling GO:0007267 52 0.078
neuroepithelial cell differentiation GO:0060563 26 0.077
regulation of epithelial cell proliferation GO:0050678 3 0.076
Mouse
inner ear receptor cell differentiation GO:0060113 29 0.076
negative regulation of wnt signaling pathway GO:0030178 30 0.076
osteoblast differentiation GO:0001649 5 0.075
regulation of bone mineralization GO:0030500 2 0.075
otolith development GO:0048840 32 0.074
gastrulation with mouth forming second GO:0001702 44 0.073
renal system development GO:0072001 94 0.073
Mouse
negative regulation of proteolysis GO:0045861 10 0.072
regulation of dna templated transcription elongation GO:0032784 3 0.072
neurological system process GO:0050877 62 0.072
pericardium morphogenesis GO:0003344 1 0.071
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.071
neuron projection development GO:0031175 180 0.071
Zebrafish Fly
medial fin morphogenesis GO:0035141 14 0.071
response to growth factor GO:0070848 39 0.070
microtubule based process GO:0007017 60 0.070
regulation of cell cycle GO:0051726 52 0.070
Mouse Fly
striated muscle cell development GO:0055002 108 0.070
neuron fate commitment GO:0048663 26 0.069
cell cycle process GO:0022402 53 0.068
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.068
protein complex biogenesis GO:0070271 30 0.068
macromolecular complex subunit organization GO:0043933 74 0.067
regulation of protein transport GO:0051223 3 0.067
Fly
multicellular organism growth GO:0035264 4 0.067
Mouse Worm
regulation of multicellular organismal metabolic process GO:0044246 2 0.067
forebrain development GO:0030900 96 0.066
floor plate development GO:0033504 15 0.066
negative regulation of metabolic process GO:0009892 86 0.065
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.064
cell proliferation GO:0008283 80 0.064
Mouse
sensory system development GO:0048880 76 0.064
endocardial cushion morphogenesis GO:0003203 3 0.063
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.063
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.062
morphogenesis of an epithelium GO:0002009 333 0.062
Mouse
hair cell differentiation GO:0035315 32 0.061
positive regulation of metabolic process GO:0009893 108 0.061
hatching GO:0035188 4 0.061
regulation of gene expression GO:0010468 265 0.061
spinal cord radial glial cell differentiation GO:0021531 2 0.061
anatomical structure homeostasis GO:0060249 36 0.060
single organism transport GO:0044765 206 0.060
Fly
pronephros development GO:0048793 69 0.060
cell projection organization GO:0030030 284 0.059
Zebrafish Fly
cell death GO:0008219 121 0.059
Fly
regulation of programmed cell death GO:0043067 101 0.058
Fly
cellular component assembly GO:0022607 170 0.058
positive regulation of cellular metabolic process GO:0031325 94 0.057
epithelial tube morphogenesis GO:0060562 148 0.057
Mouse
lens development in camera type eye GO:0002088 22 0.057
regulation of biomineral tissue development GO:0070167 2 0.057
positive regulation of gliogenesis GO:0014015 2 0.057
negative regulation of biological process GO:0048519 304 0.057
positive regulation of epithelial cell differentiation GO:0030858 2 0.057
neuromast development GO:0048884 46 0.057
eye photoreceptor cell differentiation GO:0001754 45 0.056
establishment of protein localization to organelle GO:0072594 4 0.056
Fly
regulation of heart contraction GO:0008016 32 0.055
regulation of rna biosynthetic process GO:2001141 213 0.055
blood circulation GO:0008015 87 0.055
regulation of developmental process GO:0050793 247 0.054
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.054
cerebellar cortex development GO:0021695 5 0.053
determination of intestine left right asymmetry GO:0071908 2 0.053
cell migration in hindbrain GO:0021535 7 0.053
digestive system process GO:0022600 9 0.053
vasculogenesis GO:0001570 41 0.052
positive regulation of neural precursor cell proliferation GO:2000179 1 0.052
spinal cord dorsal ventral patterning GO:0021513 5 0.052
morphogenesis of an epithelial fold GO:0060571 1 0.052
muscle fiber development GO:0048747 52 0.052
oogenesis GO:0048477 14 0.051
Worm Fly
meiotic nuclear division GO:0007126 4 0.051
regulation of autophagy GO:0010506 3 0.050
regulation of cellular metabolic process GO:0031323 320 0.050
epidermal cell differentiation GO:0009913 36 0.050
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.050
negative regulation of multicellular organismal process GO:0051241 69 0.050
cell fate specification involved in pattern specification GO:0060573 3 0.050
epithelial tube formation GO:0072175 19 0.050
Mouse
nucleic acid templated transcription GO:0097659 181 0.049
negative regulation of catabolic process GO:0009895 3 0.049
sensory perception of mechanical stimulus GO:0050954 16 0.049
heart formation GO:0060914 13 0.049
maintenance of gastrointestinal epithelium GO:0030277 7 0.048
central nervous system projection neuron axonogenesis GO:0021952 15 0.048
striated muscle tissue development GO:0014706 110 0.048
rna biosynthetic process GO:0032774 181 0.047
regulation of neuron projection development GO:0010975 40 0.047
negative regulation of cellular biosynthetic process GO:0031327 55 0.047
regulation of stem cell differentiation GO:2000736 4 0.047
organic hydroxy compound biosynthetic process GO:1901617 6 0.046
vasculature development GO:0001944 278 0.046
inner ear receptor cell fate commitment GO:0060120 4 0.046
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.046
establishment of localization GO:0051234 244 0.045
Worm Fly
rhombomere development GO:0021546 19 0.045
regulation of endodermal cell differentiation GO:1903224 15 0.044
positive regulation of cell activation GO:0050867 1 0.044
cellular component morphogenesis GO:0032989 336 0.044
Zebrafish Fly
smoothened signaling pathway GO:0007224 30 0.044
positive regulation of transport GO:0051050 2 0.044
positive regulation of rna biosynthetic process GO:1902680 57 0.044
immune system development GO:0002520 191 0.044
radial glial cell differentiation GO:0060019 2 0.044
urogenital system development GO:0001655 97 0.043
Mouse
regulation of myelination GO:0031641 1 0.043
positive regulation of mesoderm development GO:2000382 1 0.043
rhombomere morphogenesis GO:0021593 17 0.043
organ formation GO:0048645 17 0.043
mesenchymal cell development GO:0014031 78 0.043
glomerulus development GO:0032835 27 0.043
facial nerve development GO:0021561 3 0.042
regulation of canonical wnt signaling pathway GO:0060828 34 0.042
forebrain dorsal ventral pattern formation GO:0021798 1 0.042
semicircular canal morphogenesis GO:0048752 18 0.042
response to wounding GO:0009611 116 0.041
oocyte maturation GO:0001556 4 0.041
phosphate containing compound metabolic process GO:0006796 108 0.041
multicellular organismal macromolecule metabolic process GO:0044259 2 0.041
pharyngeal muscle development GO:0043282 4 0.041
single organism organelle organization GO:1902589 199 0.040
cellular response to organic substance GO:0071310 105 0.040
Mouse
axial mesoderm development GO:0048318 10 0.040
developmental induction GO:0031128 10 0.040
somatic stem cell maintenance GO:0035019 1 0.039
hormone metabolic process GO:0042445 19 0.039
neuromast hair cell development GO:0035675 6 0.039
regulation of cellular component movement GO:0051270 55 0.039
Fly
regulation of growth GO:0040008 42 0.039
Mouse Worm
protein maturation GO:0051604 12 0.039
Mouse
adenohypophysis morphogenesis GO:0048855 4 0.039
photoreceptor cell fate specification GO:0043704 1 0.039
mitotic cell cycle process GO:1903047 48 0.039
vestibular receptor cell development GO:0060118 3 0.038
protein complex assembly GO:0006461 30 0.038
phosphorus metabolic process GO:0006793 109 0.038
regulation of mitotic cell cycle GO:0007346 25 0.037
Mouse Fly
olfactory lobe development GO:0021988 4 0.037
lipid storage GO:0019915 1 0.037
Worm
anterior commissure morphogenesis GO:0021960 3 0.037
protein modification process GO:0036211 100 0.036
collagen metabolic process GO:0032963 2 0.036

ptch1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
osteochondrodysplasia DOID:2256 0 0.254
bone development disease DOID:0080006 0 0.254
bone disease DOID:0080001 0 0.254
disease of anatomical entity DOID:7 0 0.254
musculoskeletal system disease DOID:17 0 0.254
connective tissue disease DOID:65 0 0.254
endocrine system disease DOID:28 0 0.171
disease of mental health DOID:150 0 0.037
developmental disorder of mental health DOID:0060037 0 0.037