Danio rerio

0 known processes

ptgds

prostaglandin D2 synthase

(Aliases: wu:fb10b10,hm:zeh0800,wu:fb11h03)

ptgds biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to chemical GO:0042221 320 0.590
larval development GO:0002164 2 0.502
response to biotic stimulus GO:0009607 97 0.463
Mouse
extrinsic apoptotic signaling pathway GO:0097191 3 0.378
Mouse
circadian sleep wake cycle GO:0042745 2 0.354
Mouse
response to organic substance GO:0010033 153 0.341
response to virus GO:0009615 21 0.327
Mouse
response to external stimulus GO:0009605 264 0.276
Mouse
circadian sleep wake cycle sleep GO:0050802 1 0.260
Mouse
muscle cell differentiation GO:0042692 139 0.243
defense response GO:0006952 47 0.238
Mouse
response to xenobiotic stimulus GO:0009410 45 0.226
innate immune response GO:0045087 13 0.225
Mouse
signal transduction in absence of ligand GO:0038034 1 0.215
Mouse
response to other organism GO:0051707 97 0.183
Mouse
circadian sleep wake cycle process GO:0022410 2 0.177
Mouse
immune system process GO:0002376 241 0.173
Mouse
cell surface receptor signaling pathway GO:0007166 325 0.169
Mouse
positive regulation of biological process GO:0048518 253 0.163
biosynthetic process GO:0009058 294 0.160
Mouse
transport GO:0006810 220 0.160
Mouse
death GO:0016265 121 0.154
Mouse
aging GO:0007568 2 0.153
muscle cell development GO:0055001 115 0.149
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.149
Mouse
cell projection organization GO:0030030 284 0.144
regulation of endothelial cell proliferation GO:0001936 1 0.128
neuron projection development GO:0031175 180 0.125
cellular component biogenesis GO:0044085 178 0.122
sleep GO:0030431 1 0.121
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.115
maintenance of location GO:0051235 4 0.114
response to glucocorticoid GO:0051384 1 0.107
fatty acid biosynthetic process GO:0006633 4 0.106
Mouse
regulation of multicellular organismal process GO:0051239 277 0.103
Mouse
regulation of response to stimulus GO:0048583 269 0.100
Mouse
positive regulation of catabolic process GO:0009896 4 0.098
response to vitamin GO:0033273 3 0.093
single organism localization GO:1902578 225 0.092
Mouse
regulation of circadian rhythm GO:0042752 4 0.090
Mouse
cell morphogenesis GO:0000902 289 0.090
immune system development GO:0002520 191 0.084
skeletal muscle organ development GO:0060538 78 0.084
carboxylic acid metabolic process GO:0019752 22 0.082
Mouse
muscle structure development GO:0061061 196 0.081
locomotion GO:0040011 313 0.080
behavior GO:0007610 74 0.079
Mouse
monocarboxylic acid biosynthetic process GO:0072330 12 0.075
Mouse
neuron projection morphogenesis GO:0048812 161 0.073
generation of neurons GO:0048699 385 0.073
regulation of signaling GO:0023051 235 0.070
positive regulation of cellular component biogenesis GO:0044089 3 0.070
regulation of signal transduction GO:0009966 225 0.069
cellular response to xenobiotic stimulus GO:0071466 35 0.069
muscle tissue development GO:0060537 110 0.068
digestive system development GO:0055123 289 0.067
response to nutrient GO:0007584 3 0.067
leukocyte proliferation GO:0070661 1 0.067
cellular component assembly involved in morphogenesis GO:0010927 107 0.065
rhythmic process GO:0048511 21 0.062
Mouse
response to corticosteroid GO:0031960 1 0.062
adult behavior GO:0030534 2 0.062
negative regulation of biological process GO:0048519 304 0.062
regulation of epithelial cell proliferation GO:0050678 3 0.059
cellular component morphogenesis GO:0032989 336 0.059
endocrine hormone secretion GO:0060986 2 0.058
lipid biosynthetic process GO:0008610 22 0.058
Mouse
response to hexose GO:0009746 3 0.057
regulation of nitrogen compound metabolic process GO:0051171 251 0.057
lipid storage GO:0019915 1 0.057
positive regulation of cellular catabolic process GO:0031331 3 0.056
cellular biosynthetic process GO:0044249 286 0.055
Mouse
chemotaxis GO:0006935 104 0.052
small molecule metabolic process GO:0044281 77 0.051
Mouse
signal transduction GO:0007165 455 0.050
Mouse
regulation of cell communication GO:0010646 232 0.049
organic substance biosynthetic process GO:1901576 289 0.049
Mouse
notochord development GO:0030903 54 0.048
positive regulation of epithelial cell migration GO:0010634 2 0.048
apoptotic process GO:0006915 116 0.048
Mouse
cellular component movement GO:0006928 335 0.046
steroid hormone secretion GO:0035929 1 0.046
striated muscle cell development GO:0055002 108 0.046
organelle assembly GO:0070925 110 0.046
cellular localization GO:0051641 97 0.045
Mouse
cell projection morphogenesis GO:0048858 244 0.043
morphogenesis of an epithelium GO:0002009 333 0.043
regulation of hormone secretion GO:0046883 2 0.042
single organism transport GO:0044765 206 0.042
Mouse
neuron projection regeneration GO:0031102 16 0.042
muscle organ development GO:0007517 101 0.042
cellular aromatic compound metabolic process GO:0006725 295 0.042
cell substrate adhesion GO:0031589 4 0.042
cellular response to chemical stimulus GO:0070887 157 0.041
response to cadmium ion GO:0046686 14 0.041
positive regulation of protein complex assembly GO:0031334 2 0.041
regulation of gene expression GO:0010468 265 0.041
extracellular structure organization GO:0043062 27 0.040
cellular component assembly GO:0022607 170 0.040
cellular response to oxygen levels GO:0071453 1 0.039
nucleic acid metabolic process GO:0090304 244 0.039
response to light stimulus GO:0009416 46 0.039
cognition GO:0050890 1 0.038
regulation of circadian sleep wake cycle GO:0042749 1 0.038
Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.038
embryo development ending in birth or egg hatching GO:0009792 271 0.038
cell motility GO:0048870 244 0.037
guanosine containing compound metabolic process GO:1901068 4 0.037
regulation of protein complex assembly GO:0043254 3 0.037
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.037
negative regulation of kinase activity GO:0033673 4 0.037
cellular response to decreased oxygen levels GO:0036294 1 0.036
positive regulation of cell cycle GO:0045787 3 0.036
regulation of protein catabolic process GO:0042176 1 0.036
positive regulation of transport GO:0051050 2 0.036
regulation of cell activation GO:0050865 1 0.035
response to organic cyclic compound GO:0014070 51 0.035
regeneration GO:0031099 91 0.035
endocrine process GO:0050886 2 0.035
regulation of inflammatory response GO:0050727 2 0.035
cellular response to stress GO:0033554 62 0.034
regulation of macromolecule metabolic process GO:0060255 317 0.034
multi organism process GO:0051704 134 0.034
Mouse
cell morphogenesis involved in differentiation GO:0000904 195 0.034
determination of bilateral symmetry GO:0009855 204 0.034
secondary metabolic process GO:0019748 3 0.034
cellular lipid metabolic process GO:0044255 36 0.033
Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.033
regulation of response to oxidative stress GO:1902882 2 0.033
response to carbohydrate GO:0009743 3 0.032
response to radiation GO:0009314 51 0.032
cerebellar granular layer development GO:0021681 3 0.032
negative regulation of cellular process GO:0048523 283 0.032
lipid catabolic process GO:0016042 4 0.032
regulation of wound healing GO:0061041 2 0.031
response to topologically incorrect protein GO:0035966 2 0.031
regulation of cellular amine metabolic process GO:0033238 0 0.031
organic acid metabolic process GO:0006082 31 0.031
Mouse
positive regulation of cytoskeleton organization GO:0051495 3 0.031
cell part morphogenesis GO:0032990 246 0.030
multicellular organism growth GO:0035264 4 0.030
cellular ketone metabolic process GO:0042180 11 0.030
gene expression GO:0010467 252 0.030
single organism metabolic process GO:0044710 217 0.029
Mouse
protein acetylation GO:0006473 2 0.029
striated muscle tissue development GO:0014706 110 0.029
odontogenesis of dentin containing tooth GO:0042475 1 0.028
cell death GO:0008219 121 0.028
Mouse
regulation of cellular response to oxidative stress GO:1900407 2 0.028
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.028
Mouse
lipid metabolic process GO:0006629 52 0.028
Mouse
regulation of reactive oxygen species metabolic process GO:2000377 2 0.027
gtp metabolic process GO:0046039 4 0.027
response to monosaccharide GO:0034284 3 0.027
estrogen metabolic process GO:0008210 2 0.027
neuron projection guidance GO:0097485 86 0.027
zymogen activation GO:0031638 3 0.027
regulation of cytokine production GO:0001817 3 0.027
head development GO:0060322 303 0.027
protein polymerization GO:0051258 4 0.026
positive regulation of cell activation GO:0050867 1 0.026
regulation of cell migration GO:0030334 40 0.026
regulation of developmental process GO:0050793 247 0.026
regulation of transcription involved in cell fate commitment GO:0060850 1 0.026
rna biosynthetic process GO:0032774 181 0.025
neuroblast proliferation GO:0007405 2 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
fatty acid transport GO:0015908 1 0.024
regulation of protein polymerization GO:0032271 2 0.024
single organism organelle organization GO:1902589 199 0.024
reactive oxygen species biosynthetic process GO:1903409 1 0.024
ear development GO:0043583 127 0.024
ovulation cycle GO:0042698 2 0.024
phagocytosis GO:0006909 3 0.024
nucleobase containing compound metabolic process GO:0006139 274 0.023
hormone transport GO:0009914 2 0.023
positive regulation of epithelial cell proliferation GO:0050679 1 0.023
eye development GO:0001654 277 0.023
reactive nitrogen species metabolic process GO:2001057 0 0.023
cell migration GO:0016477 237 0.023
positive regulation of response to stimulus GO:0048584 80 0.023
amine metabolic process GO:0009308 2 0.023
negative regulation of epithelial cell proliferation GO:0050680 1 0.023
enzyme linked receptor protein signaling pathway GO:0007167 106 0.023
specification of symmetry GO:0009799 204 0.022
protein secretion GO:0009306 1 0.022
reactive oxygen species metabolic process GO:0072593 6 0.022
regulation of rho protein signal transduction GO:0035023 2 0.022
anion transport GO:0006820 38 0.022
cellular hormone metabolic process GO:0034754 19 0.022
negative regulation of reproductive process GO:2000242 3 0.022
regulation of protein binding GO:0043393 3 0.022
cell junction maintenance GO:0034331 2 0.022
neuron neuron synaptic transmission GO:0007270 1 0.022
rna metabolic process GO:0016070 219 0.022
negative regulation of hormone secretion GO:0046888 2 0.021
cellular response to hypoxia GO:0071456 1 0.021
neuron development GO:0048666 262 0.021
skeletal muscle tissue development GO:0007519 67 0.021
response to oxygen containing compound GO:1901700 55 0.021
single organism biosynthetic process GO:0044711 71 0.021
Mouse
negative regulation of response to stimulus GO:0048585 104 0.021
regulation of multicellular organism growth GO:0040014 4 0.021
regulation of binding GO:0051098 3 0.020
tissue remodeling GO:0048771 4 0.020
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.020
negative regulation of epithelial cell migration GO:0010633 1 0.020
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.020
protein complex disassembly GO:0043241 1 0.020
regulation of establishment of protein localization GO:0070201 4 0.020
regulation of receptor activity GO:0010469 2 0.020
actin filament based process GO:0030029 64 0.020
neurotransmitter secretion GO:0007269 2 0.020
regulation of metabolic process GO:0019222 359 0.020
positive regulation of cgmp biosynthetic process GO:0030828 6 0.020
stem cell maintenance GO:0019827 4 0.019
response to amino acid GO:0043200 2 0.019
positive regulation of gene expression GO:0010628 71 0.019
vasculature development GO:0001944 278 0.019
regulation of nucleic acid templated transcription GO:1903506 213 0.019
beta amyloid metabolic process GO:0050435 1 0.019
gtp catabolic process GO:0006184 2 0.019
regulation of localization GO:0032879 104 0.019
positive regulation of inflammatory response GO:0050729 1 0.019
embryonic limb morphogenesis GO:0030326 2 0.019
stem cell proliferation GO:0072089 4 0.019
lateral inhibition GO:0046331 1 0.018
membrane invagination GO:0010324 1 0.018
heterocycle biosynthetic process GO:0018130 215 0.018
regulation of autophagy GO:0010506 3 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
heart development GO:0007507 313 0.018
regulation of apoptotic process GO:0042981 98 0.018
positive regulation of secretion by cell GO:1903532 1 0.018
ovarian follicle development GO:0001541 2 0.018
reproduction GO:0000003 40 0.018
ovulation cycle process GO:0022602 2 0.018
phagocytosis engulfment GO:0006911 1 0.018
cellular response to endogenous stimulus GO:0071495 68 0.018
carboxylic acid biosynthetic process GO:0046394 12 0.018
Mouse
regulation of cellular protein catabolic process GO:1903362 1 0.018
negative regulation of protein phosphorylation GO:0001933 4 0.018
regulation of multicellular organismal development GO:2000026 223 0.017
cell matrix adhesion GO:0007160 4 0.017
response to stress GO:0006950 263 0.017
Mouse
mononuclear cell proliferation GO:0032943 1 0.017
peptide metabolic process GO:0006518 1 0.017
positive regulation of nucleic acid templated transcription GO:1903508 57 0.017
regulation of rna metabolic process GO:0051252 224 0.017
regulation of biological quality GO:0065008 263 0.017
alcohol biosynthetic process GO:0046165 2 0.017
response to glucose GO:0009749 3 0.017
myeloid cell differentiation GO:0030099 86 0.017
cell cycle g1 s phase transition GO:0044843 1 0.017
i kappab kinase nf kappab signaling GO:0007249 4 0.017
aromatic compound biosynthetic process GO:0019438 217 0.017
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.017
localization of cell GO:0051674 244 0.016
negative regulation of secretion GO:0051048 2 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
detection of external stimulus GO:0009581 24 0.016
er nucleus signaling pathway GO:0006984 2 0.016
cellular response to prostaglandin stimulus GO:0071379 3 0.016
cellular amine metabolic process GO:0044106 2 0.016
cellular component disassembly GO:0022411 1 0.016
astrocyte differentiation GO:0048708 1 0.016
hematopoietic or lymphoid organ development GO:0048534 191 0.016
single organism membrane fusion GO:0044801 2 0.016
tube morphogenesis GO:0035239 349 0.015
positive regulation of biosynthetic process GO:0009891 68 0.015
response to hypoxia GO:0001666 25 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
regulation of biomineral tissue development GO:0070167 2 0.015
regulation of cell differentiation GO:0045595 142 0.015
neurological system process GO:0050877 62 0.015
regulation of transcription dna templated GO:0006355 213 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.015
programmed cell death GO:0012501 119 0.015
Mouse
regulation of steroid hormone secretion GO:2000831 1 0.015
regulation of tube size GO:0035150 2 0.015
single organism behavior GO:0044708 24 0.015
Mouse
embryonic organ morphogenesis GO:0048562 274 0.015
response to drug GO:0042493 3 0.015
regulation of cellular biosynthetic process GO:0031326 245 0.015
cellular response to radiation GO:0071478 4 0.014
autophagy GO:0006914 4 0.014
regulation of biosynthetic process GO:0009889 250 0.014
regulation of filopodium assembly GO:0051489 2 0.014
neurotransmitter transport GO:0006836 2 0.014
nucleocytoplasmic transport GO:0006913 4 0.014
establishment or maintenance of monopolar cell polarity GO:0061339 2 0.014
response to alkaloid GO:0043279 2 0.014
organic cyclic compound metabolic process GO:1901360 301 0.014
spermatid development GO:0007286 2 0.014
response to antibiotic GO:0046677 1 0.014
nitric oxide biosynthetic process GO:0006809 2 0.014
post embryonic organ morphogenesis GO:0048563 1 0.014
eye morphogenesis GO:0048592 144 0.014
apoptotic signaling pathway GO:0097190 23 0.014
Mouse
internal peptidyl lysine acetylation GO:0018393 2 0.014
protein targeting to nucleus GO:0044744 3 0.014
positive regulation of protein kinase b signaling GO:0051897 1 0.014
protein homooligomerization GO:0051260 3 0.014
motor neuron axon guidance GO:0008045 23 0.014
hemopoiesis GO:0030097 183 0.014
long chain fatty acid transport GO:0015909 1 0.014
positive regulation of neuron death GO:1901216 1 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
negative regulation of cell communication GO:0010648 96 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
regulation of gtpase activity GO:0043087 2 0.013
male meiosis GO:0007140 2 0.013
sensory organ morphogenesis GO:0090596 200 0.013
cell cell junction maintenance GO:0045217 1 0.013
regulation of growth rate GO:0040009 1 0.013
negative regulation of endothelial cell migration GO:0010596 1 0.013
catabolic process GO:0009056 32 0.013
regulation of cgmp biosynthetic process GO:0030826 6 0.013
regulation of gtp catabolic process GO:0033124 2 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
response to metal ion GO:0010038 34 0.013
organic acid biosynthetic process GO:0016053 12 0.013
Mouse
urogenital system development GO:0001655 97 0.013
regulation of lipid transport GO:0032368 4 0.013
actin filament polymerization GO:0030041 2 0.013
regulation of dendrite development GO:0050773 3 0.013
carbohydrate biosynthetic process GO:0016051 1 0.013
positive regulation of translation GO:0045727 1 0.013
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.013
nucleic acid templated transcription GO:0097659 181 0.012
striated muscle cell differentiation GO:0051146 129 0.012
cellular macromolecule metabolic process GO:0044260 391 0.012
calcium ion import GO:0070509 4 0.012
response to acid chemical GO:0001101 17 0.012
cellular response to unfolded protein GO:0034620 2 0.012
nitrogen compound metabolic process GO:0006807 319 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
cell substrate adherens junction assembly GO:0007045 1 0.012
organelle organization GO:0006996 227 0.012
female sex differentiation GO:0046660 4 0.012
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.012
postsynaptic membrane organization GO:0001941 3 0.012
organelle fusion GO:0048284 3 0.012
gland development GO:0048732 143 0.012
melanin metabolic process GO:0006582 2 0.012
nuclear transport GO:0051169 4 0.012
chromosome organization involved in meiosis GO:0070192 1 0.012
lipoprotein biosynthetic process GO:0042158 3 0.012
cellular response to topologically incorrect protein GO:0035967 2 0.012
cellular macromolecule biosynthetic process GO:0034645 224 0.012
detection of abiotic stimulus GO:0009582 24 0.012
negative regulation of defense response GO:0031348 2 0.012
axon development GO:0061564 166 0.012
positive regulation of cell division GO:0051781 2 0.012
positive regulation of secretion GO:0051047 1 0.012
regulation of protein transport GO:0051223 3 0.012
heterocycle metabolic process GO:0046483 290 0.012
extracellular matrix organization GO:0030198 27 0.012
nephron morphogenesis GO:0072028 2 0.012
regulation of immune system process GO:0002682 34 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
post embryonic organ development GO:0048569 4 0.011
atp catabolic process GO:0006200 4 0.011
response to external biotic stimulus GO:0043207 97 0.011
Mouse
nitric oxide metabolic process GO:0046209 2 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.011
regulation of organelle organization GO:0033043 29 0.011
regulation of cell proliferation GO:0042127 37 0.011
cellular response to methanol GO:0071405 4 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
regulation of blood vessel size GO:0050880 2 0.011
cellular protein catabolic process GO:0044257 4 0.011
regulation of blood coagulation GO:0030193 1 0.011
purine nucleoside monophosphate catabolic process GO:0009128 4 0.011
organic cyclic compound biosynthetic process GO:1901362 223 0.011
peptidyl serine phosphorylation GO:0018105 1 0.011
oocyte maturation GO:0001556 4 0.011
system process GO:0003008 185 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
g1 s transition of mitotic cell cycle GO:0000082 1 0.011
small molecule catabolic process GO:0044282 3 0.011
endodermal cell fate determination GO:0007493 2 0.011
regulation of protein ubiquitination GO:0031396 3 0.011
hormone secretion GO:0046879 2 0.011
multicellular organismal homeostasis GO:0048871 29 0.011
inositol lipid mediated signaling GO:0048017 2 0.011
small molecule biosynthetic process GO:0044283 16 0.010
Mouse
regulation of cell projection assembly GO:0060491 4 0.010
sister chromatid cohesion GO:0007062 2 0.010
regulation of cytoplasmic transport GO:1903649 4 0.010
equilibrioception GO:0050957 2 0.010
cell death in response to oxidative stress GO:0036473 2 0.010
phosphorus metabolic process GO:0006793 109 0.010
protein import GO:0017038 3 0.010
establishment of apical basal cell polarity GO:0035089 2 0.010
endoplasmic reticulum unfolded protein response GO:0030968 2 0.010
one carbon compound transport GO:0019755 14 0.010
glucocorticoid metabolic process GO:0008211 2 0.010
response to methylmercury GO:0051597 11 0.010
neuron differentiation GO:0030182 353 0.010
macromolecule biosynthetic process GO:0009059 227 0.010
polarized epithelial cell differentiation GO:0030859 4 0.010
microtubule polymerization GO:0046785 2 0.010
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.010
blood vessel development GO:0001568 246 0.010
cgmp biosynthetic process GO:0006182 7 0.010
positive regulation of signaling GO:0023056 56 0.010
response to decreased oxygen levels GO:0036293 25 0.010
regulation of myotube differentiation GO:0010830 2 0.010
embryonic organ development GO:0048568 381 0.010
beta amyloid formation GO:0034205 1 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010

ptgds disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.023
disease of anatomical entity DOID:7 0 0.023
central nervous system disease DOID:331 0 0.021
tauopathy DOID:680 0 0.021
neurodegenerative disease DOID:1289 0 0.021
nervous system disease DOID:863 0 0.021
dementia DOID:1307 0 0.014
alzheimer s disease DOID:10652 0 0.014
disease of mental health DOID:150 0 0.014
cognitive disorder DOID:1561 0 0.014
disease of metabolism DOID:0014667 0 0.014
lysosomal storage disease DOID:3211 0 0.014
inherited metabolic disorder DOID:655 0 0.014
bone development disease DOID:0080006 0 0.011
bone disease DOID:0080001 0 0.011
musculoskeletal system disease DOID:17 0 0.011
connective tissue disease DOID:65 0 0.011