Danio rerio

51 known processes

ptpro

protein tyrosine phosphatase, receptor type, O

(Aliases: zgc:158179)

ptpro biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic organ development GO:0048568 381 0.303
generation of neurons GO:0048699 385 0.266
cell death GO:0008219 121 0.211
negative regulation of axon regeneration GO:0048681 4 0.196
angioblast cell migration involved in selective angioblast sprouting GO:0035475 4 0.166
negative regulation of neuron projection regeneration GO:0070571 4 0.160
synaptic target recognition GO:0008039 1 0.151
morphogenesis of an epithelium GO:0002009 333 0.150
intracellular signal transduction GO:0035556 85 0.113
synaptic growth at neuromuscular junction GO:0051124 2 0.106
collateral sprouting of intact axon in response to injury GO:0048673 2 0.106
regulation of collateral sprouting of intact axon in response to injury GO:0048683 2 0.104
signal transduction GO:0007165 455 0.104
cell projection morphogenesis GO:0048858 244 0.098
cell part morphogenesis GO:0032990 246 0.097
cell surface receptor signaling pathway GO:0007166 325 0.095
death GO:0016265 121 0.088
neural retina development GO:0003407 49 0.079
head development GO:0060322 303 0.078
negative regulation of cellular process GO:0048523 283 0.078
dendrite guidance GO:0070983 0 0.074
neuron projection development GO:0031175 180 0.073
small gtpase mediated signal transduction GO:0007264 8 0.069
ion homeostasis GO:0050801 41 0.069
brain development GO:0007420 293 0.067
central nervous system development GO:0007417 387 0.067
regulation of neuron projection regeneration GO:0070570 7 0.067
cell substrate adhesion GO:0031589 4 0.065
regulation of neuron differentiation GO:0045664 56 0.065
regulation of cell projection organization GO:0031344 44 0.065
regulation of axonogenesis GO:0050770 32 0.061
postsynaptic membrane organization GO:0001941 3 0.060
negative regulation of programmed cell death GO:0043069 58 0.060
developmental maturation GO:0021700 34 0.058
eye development GO:0001654 277 0.057
regulation of nucleoside metabolic process GO:0009118 2 0.057
guanosine containing compound metabolic process GO:1901068 4 0.055
inorganic ion transmembrane transport GO:0098660 57 0.054
negative regulation of multicellular organismal process GO:0051241 69 0.052
regulation of reproductive process GO:2000241 4 0.049
gtp metabolic process GO:0046039 4 0.048
regulation of synapse organization GO:0050807 3 0.047
regulation of programmed cell death GO:0043067 101 0.046
regulation of neurogenesis GO:0050767 87 0.045
formation of anatomical boundary GO:0048859 14 0.045
regulation of neural retina development GO:0061074 2 0.045
transmembrane transport GO:0055085 120 0.044
hindbrain formation GO:0021576 3 0.044
positive regulation of cellular component biogenesis GO:0044089 3 0.043
oocyte maturation GO:0001556 4 0.042
response to external stimulus GO:0009605 264 0.042
regulation of synapse assembly GO:0051963 3 0.040
regulation of neuron projection development GO:0010975 40 0.040
inorganic anion transport GO:0015698 25 0.039
forebrain regionalization GO:0021871 4 0.039
growth GO:0040007 174 0.038
regulation of retina development in camera type eye GO:1902866 2 0.037
neuron differentiation GO:0030182 353 0.037
negative regulation of axon extension GO:0030517 7 0.037
negative regulation of epithelial cell proliferation GO:0050680 1 0.037
regulation of purine nucleotide catabolic process GO:0033121 2 0.035
regulation of cell death GO:0010941 103 0.035
regulation of developmental process GO:0050793 247 0.034
negative regulation of histone modification GO:0031057 1 0.034
negative regulation of cell death GO:0060548 60 0.034
negative regulation of protein phosphorylation GO:0001933 4 0.034
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.033
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.032
chemotaxis GO:0006935 104 0.032
methylation GO:0032259 22 0.032
regulation of nucleotide catabolic process GO:0030811 2 0.032
regulation of dendrite development GO:0050773 3 0.031
forebrain development GO:0030900 96 0.031
cellular aromatic compound metabolic process GO:0006725 295 0.031
cell cell recognition GO:0009988 1 0.031
angioblast cell migration GO:0035476 9 0.030
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.030
morphogenesis of embryonic epithelium GO:0016331 30 0.030
developmental growth GO:0048589 166 0.030
cellular response to chemical stimulus GO:0070887 157 0.029
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.029
regulation of cellular component organization GO:0051128 86 0.029
regulation of epithelial cell proliferation GO:0050678 3 0.029
cilium organization GO:0044782 71 0.029
camera type eye morphogenesis GO:0048593 108 0.029
forebrain anterior posterior pattern specification GO:0021797 3 0.029
negative regulation of collateral sprouting of intact axon in response to injury GO:0048685 2 0.029
cellular protein metabolic process GO:0044267 129 0.028
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.028
ion transmembrane transport GO:0034220 91 0.028
adult behavior GO:0030534 2 0.027
regulation of gene expression GO:0010468 265 0.027
response to chemical GO:0042221 320 0.025
response to carbohydrate GO:0009743 3 0.025
response to organic substance GO:0010033 153 0.025
regulation of apoptotic process GO:0042981 98 0.025
negative regulation of neuron projection development GO:0010977 9 0.025
camera type eye development GO:0043010 222 0.024
negative regulation of gene expression GO:0010629 65 0.024
rhombomere boundary formation GO:0021654 10 0.024
positive regulation of synapse assembly GO:0051965 1 0.024
regulation of axon regeneration GO:0048679 7 0.024
cell migration GO:0016477 237 0.024
ion transport GO:0006811 114 0.024
tube closure GO:0060606 1 0.023
apoptotic process GO:0006915 116 0.023
brain morphogenesis GO:0048854 18 0.023
negative regulation of cellular metabolic process GO:0031324 77 0.023
motor neuron axon guidance GO:0008045 23 0.022
hair cell differentiation GO:0035315 32 0.022
regulation of gtpase activity GO:0043087 2 0.022
negative regulation of protein metabolic process GO:0051248 16 0.021
regulation of multicellular organism growth GO:0040014 4 0.021
forebrain dorsal ventral pattern formation GO:0021798 1 0.021
oligodendrocyte cell fate specification GO:0021778 4 0.021
meiotic nuclear division GO:0007126 4 0.020
maintenance of location GO:0051235 4 0.020
cellular response to stress GO:0033554 62 0.020
regulation of nervous system development GO:0051960 90 0.020
regulation of ion transmembrane transporter activity GO:0032412 2 0.020
photoreceptor cell fate commitment GO:0046552 1 0.020
development of primary female sexual characteristics GO:0046545 4 0.020
phosphorus metabolic process GO:0006793 109 0.020
cellular response to organic substance GO:0071310 105 0.020
sensory organ morphogenesis GO:0090596 200 0.020
negative regulation of cellular catabolic process GO:0031330 3 0.020
regulation of membrane potential GO:0042391 23 0.019
somite development GO:0061053 96 0.019
primary neural tube formation GO:0014020 1 0.019
negative regulation of reproductive process GO:2000242 3 0.019
embryonic skeletal system morphogenesis GO:0048704 93 0.019
negative regulation of axonogenesis GO:0050771 7 0.018
regulation of cell development GO:0060284 100 0.018
female gonad development GO:0008585 4 0.018
chordate embryonic development GO:0043009 271 0.018
axon regeneration GO:0031103 14 0.018
positive regulation of epithelial cell differentiation GO:0030858 2 0.018
cell proliferation in forebrain GO:0021846 3 0.018
regulation of dendrite morphogenesis GO:0048814 3 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.018
retinal pigment epithelium development GO:0003406 8 0.018
eye morphogenesis GO:0048592 144 0.018
cell projection organization GO:0030030 284 0.018
negative regulation of chromosome organization GO:2001251 1 0.018
cranial nerve morphogenesis GO:0021602 15 0.017
neuron development GO:0048666 262 0.017
multicellular organism growth GO:0035264 4 0.017
locomotion GO:0040011 313 0.017
nerve development GO:0021675 45 0.017
female sex differentiation GO:0046660 4 0.017
negative regulation of biological process GO:0048519 304 0.017
programmed cell death GO:0012501 119 0.017
forebrain cell migration GO:0021885 1 0.016
negative regulation of chromatin modification GO:1903309 1 0.016
guanosine containing compound catabolic process GO:1901069 2 0.016
apoptotic process involved in development GO:1902742 2 0.016
rhombomere formation GO:0021594 12 0.015
gland development GO:0048732 143 0.015
neuroblast proliferation GO:0007405 2 0.015
retina development in camera type eye GO:0060041 146 0.015
retinal cell programmed cell death GO:0046666 2 0.015
sequestering of calcium ion GO:0051208 3 0.015
regulation of primary metabolic process GO:0080090 311 0.015
positive regulation of nucleotide catabolic process GO:0030813 1 0.015
olfactory placode development GO:0071698 12 0.015
cerebellum formation GO:0021588 2 0.015
neuron projection morphogenesis GO:0048812 161 0.015
melanin metabolic process GO:0006582 2 0.015
nucleic acid metabolic process GO:0090304 244 0.014
neuron projection regeneration GO:0031102 16 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
phosphate containing compound metabolic process GO:0006796 108 0.014
phagocytosis GO:0006909 3 0.014
transport GO:0006810 220 0.014
chemical homeostasis GO:0048878 49 0.014
negative regulation of collateral sprouting GO:0048671 2 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.014
regulation of stem cell differentiation GO:2000736 4 0.014
response to endogenous stimulus GO:0009719 83 0.014
nitrogen compound metabolic process GO:0006807 319 0.014
cranial nerve development GO:0021545 42 0.014
cellular macromolecule metabolic process GO:0044260 391 0.014
regulation of receptor activity GO:0010469 2 0.014
regulation of tube size GO:0035150 2 0.014
auditory receptor cell fate commitment GO:0009912 4 0.014
negative regulation of response to stimulus GO:0048585 104 0.013
tube formation GO:0035148 25 0.013
cell motility GO:0048870 244 0.013
negative regulation of neuron differentiation GO:0045665 10 0.013
regulation of intracellular signal transduction GO:1902531 57 0.013
negative regulation of rna metabolic process GO:0051253 48 0.013
negative regulation of macromolecule metabolic process GO:0010605 76 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
regulation of dna methylation GO:0044030 5 0.013
ectodermal placode development GO:0071696 37 0.013
selective angioblast sprouting GO:0035474 5 0.013
microtubule based process GO:0007017 60 0.013
basement membrane organization GO:0071711 5 0.013
response to stress GO:0006950 263 0.013
neuronal action potential GO:0019228 18 0.013
transmission of nerve impulse GO:0019226 19 0.013
localization of cell GO:0051674 244 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
somitogenesis GO:0001756 87 0.013
cellular pigmentation GO:0033059 30 0.012
mitotic g2 dna damage checkpoint GO:0007095 3 0.012
regulation of collateral sprouting GO:0048670 7 0.012
retina morphogenesis in camera type eye GO:0060042 79 0.012
epithelial tube morphogenesis GO:0060562 148 0.012
embryonic viscerocranium morphogenesis GO:0048703 52 0.012
detection of stimulus GO:0051606 29 0.012
cell morphogenesis GO:0000902 289 0.012
negative regulation of nuclear division GO:0051784 3 0.012
negative regulation of nucleic acid templated transcription GO:1903507 45 0.012
positive regulation of signal transduction GO:0009967 56 0.012
nephron morphogenesis GO:0072028 2 0.012
response to glucose GO:0009749 3 0.012
pigmentation GO:0043473 85 0.012
cranial nerve formation GO:0021603 13 0.012
heart development GO:0007507 313 0.012
developmental programmed cell death GO:0010623 4 0.012
neuron projection extension GO:1990138 45 0.012
embryonic camera type eye development GO:0031076 29 0.012
central nervous system neuron differentiation GO:0021953 74 0.012
histone h3 k9 modification GO:0061647 5 0.011
embryonic heart tube morphogenesis GO:0003143 108 0.011
negative regulation of cellular protein metabolic process GO:0032269 16 0.011
regulation of sequestering of calcium ion GO:0051282 4 0.011
heart looping GO:0001947 94 0.011
cellular response to external stimulus GO:0071496 2 0.011
regulation of hydrolase activity GO:0051336 28 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
central nervous system projection neuron axonogenesis GO:0021952 15 0.011
establishment of localization GO:0051234 244 0.011
gtp catabolic process GO:0006184 2 0.011
female gamete generation GO:0007292 14 0.011
heterocycle biosynthetic process GO:0018130 215 0.011
neuroblast differentiation GO:0014016 1 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
negative regulation of cell development GO:0010721 26 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
axon development GO:0061564 166 0.010
positive regulation of cellular catabolic process GO:0031331 3 0.010
peptide metabolic process GO:0006518 1 0.010
biosynthetic process GO:0009058 294 0.010
regulation of macromolecule metabolic process GO:0060255 317 0.010
stem cell division GO:0017145 1 0.010
cellular response to nutrient levels GO:0031669 2 0.010
compound eye development GO:0048749 2 0.010
macromolecule methylation GO:0043414 19 0.010
regulation of multicellular organismal development GO:2000026 223 0.010
single organism membrane fusion GO:0044801 2 0.010
peripheral nervous system development GO:0007422 55 0.010
cellular component movement GO:0006928 335 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
synaptic transmission cholinergic GO:0007271 4 0.010
negative regulation of protein kinase b signaling GO:0051898 2 0.010
response to oxidative stress GO:0006979 11 0.010

ptpro disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.059
nervous system disease DOID:863 0 0.059
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011