Danio rerio

0 known processes

rapgef1

Rap guanine nucleotide exchange factor (GEF) 1

(Aliases: zgc:56372,MGC56372,rapgef1b,GRF2)

rapgef1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.227
brain development GO:0007420 293 0.152
modification dependent protein catabolic process GO:0019941 3 0.135
cellular macromolecule biosynthetic process GO:0034645 224 0.120
camera type eye development GO:0043010 222 0.117
central nervous system development GO:0007417 387 0.116
embryo development ending in birth or egg hatching GO:0009792 271 0.104
regulation of signaling GO:0023051 235 0.089
cellular component movement GO:0006928 335 0.085
retina development in camera type eye GO:0060041 146 0.082
cellular nitrogen compound metabolic process GO:0034641 290 0.081
head development GO:0060322 303 0.079
heterocycle metabolic process GO:0046483 290 0.079
regulation of cell communication GO:0010646 232 0.071
rna metabolic process GO:0016070 219 0.070
nuclear transport GO:0051169 4 0.070
single organism organelle organization GO:1902589 199 0.069
cellular macromolecule metabolic process GO:0044260 391 0.067
nitrogen compound metabolic process GO:0006807 319 0.066
negative regulation of biological process GO:0048519 304 0.065
transcription dna templated GO:0006351 181 0.065
protein metabolic process GO:0019538 183 0.065
gene expression GO:0010467 252 0.064
eye development GO:0001654 277 0.060
positive regulation of map kinase activity GO:0043406 3 0.060
regulation of response to stimulus GO:0048583 269 0.060
regulation of signal transduction GO:0009966 225 0.059
regulation of multicellular organism growth GO:0040014 4 0.057
regulation of biosynthetic process GO:0009889 250 0.056
sensory organ development GO:0007423 393 0.055
skeletal system development GO:0001501 181 0.055
tube morphogenesis GO:0035239 349 0.055
organic substance biosynthetic process GO:1901576 289 0.052
organelle organization GO:0006996 227 0.052
regulation of rna biosynthetic process GO:2001141 213 0.051
maintenance of location GO:0051235 4 0.051
morphogenesis of an epithelium GO:0002009 333 0.051
positive regulation of transport GO:0051050 2 0.049
ubiquitin dependent protein catabolic process GO:0006511 3 0.048
aging GO:0007568 2 0.048
regulation of multicellular organismal development GO:2000026 223 0.046
regulation of rna metabolic process GO:0051252 224 0.046
immune system process GO:0002376 241 0.045
regulation of primary metabolic process GO:0080090 311 0.045
organic cyclic compound metabolic process GO:1901360 301 0.044
rna biosynthetic process GO:0032774 181 0.044
negative regulation of cellular process GO:0048523 283 0.044
digestive system development GO:0055123 289 0.043
positive regulation of catabolic process GO:0009896 4 0.043
digestive tract development GO:0048565 265 0.042
nucleocytoplasmic transport GO:0006913 4 0.042
regulation of transcription dna templated GO:0006355 213 0.042
generation of neurons GO:0048699 385 0.041
cell motility GO:0048870 244 0.039
cognition GO:0050890 1 0.039
regulation of multicellular organismal process GO:0051239 277 0.038
response to nutrient GO:0007584 3 0.038
nucleobase containing compound biosynthetic process GO:0034654 205 0.037
nucleobase containing compound metabolic process GO:0006139 274 0.037
peptidyl serine phosphorylation GO:0018105 1 0.037
modification dependent macromolecule catabolic process GO:0043632 3 0.036
cellular component biogenesis GO:0044085 178 0.036
regionalization GO:0003002 274 0.036
regulation of nitrogen compound metabolic process GO:0051171 251 0.035
positive regulation of stress activated mapk cascade GO:0032874 3 0.035
regulation of protein kinase b signaling GO:0051896 8 0.034
positive regulation of cellular catabolic process GO:0031331 3 0.034
aromatic compound biosynthetic process GO:0019438 217 0.034
stem cell maintenance GO:0019827 4 0.034
digestive tract morphogenesis GO:0048546 231 0.034
macromolecule biosynthetic process GO:0009059 227 0.033
signal transduction GO:0007165 455 0.033
locomotion GO:0040011 313 0.032
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.032
response to stress GO:0006950 263 0.032
cellular protein metabolic process GO:0044267 129 0.032
establishment of localization GO:0051234 244 0.032
lateral inhibition GO:0046331 1 0.032
cellular protein modification process GO:0006464 100 0.032
stem cell proliferation GO:0072089 4 0.032
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.032
regulation of macromolecule metabolic process GO:0060255 317 0.031
nucleic acid metabolic process GO:0090304 244 0.031
lipid storage GO:0019915 1 0.031
microtubule based process GO:0007017 60 0.031
taxis GO:0042330 109 0.031
regulation of gene expression GO:0010468 265 0.031
stem cell division GO:0017145 1 0.030
cellular biosynthetic process GO:0044249 286 0.030
regulation of developmental process GO:0050793 247 0.030
multicellular organism growth GO:0035264 4 0.030
regulation of glucose import GO:0046324 1 0.030
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.030
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.030
regulation of macromolecule biosynthetic process GO:0010556 225 0.029
dorsal ventral pattern formation GO:0009953 125 0.029
response to external stimulus GO:0009605 264 0.029
embryonic organ morphogenesis GO:0048562 274 0.029
cell surface receptor signaling pathway GO:0007166 325 0.029
organic cyclic compound biosynthetic process GO:1901362 223 0.029
positive regulation of jnk cascade GO:0046330 3 0.029
regulation of establishment of protein localization GO:0070201 4 0.028
cellular component morphogenesis GO:0032989 336 0.028
neuron projection guidance GO:0097485 86 0.028
cellular component assembly GO:0022607 170 0.028
embryonic organ development GO:0048568 381 0.028
positive regulation of macromolecule metabolic process GO:0010604 93 0.027
localization of cell GO:0051674 244 0.027
macromolecule modification GO:0043412 111 0.027
immune system development GO:0002520 191 0.027
regulation of cellular biosynthetic process GO:0031326 245 0.026
mitotic cell cycle GO:0000278 64 0.026
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.026
hemopoiesis GO:0030097 183 0.026
hindbrain development GO:0030902 91 0.026
response to chemical GO:0042221 320 0.026
axonogenesis GO:0007409 152 0.026
regulation of carbohydrate metabolic process GO:0006109 4 0.025
heart development GO:0007507 313 0.025
biosynthetic process GO:0009058 294 0.025
response to abiotic stimulus GO:0009628 122 0.025
negative regulation of protein phosphorylation GO:0001933 4 0.025
neuron development GO:0048666 262 0.025
heterocycle biosynthetic process GO:0018130 215 0.025
cellular nitrogen compound biosynthetic process GO:0044271 218 0.024
regulation of binding GO:0051098 3 0.024
phagocytosis GO:0006909 3 0.024
organic acid metabolic process GO:0006082 31 0.024
positive regulation of response to stimulus GO:0048584 80 0.024
response to carbohydrate GO:0009743 3 0.024
gastrulation GO:0007369 208 0.024
cellular response to chemical stimulus GO:0070887 157 0.023
oxoacid metabolic process GO:0043436 31 0.023
cellular localization GO:0051641 97 0.023
positive regulation of cell cycle GO:0045787 3 0.023
positive regulation of protein kinase b signaling GO:0051897 1 0.023
negative regulation of cell communication GO:0010648 96 0.023
protein modification process GO:0036211 100 0.023
regulation of synapse assembly GO:0051963 3 0.023
positive regulation of dna metabolic process GO:0051054 1 0.023
regulation of nucleic acid templated transcription GO:1903506 213 0.023
regulation of protein targeting GO:1903533 2 0.023
gland development GO:0048732 143 0.023
negative regulation of signaling GO:0023057 96 0.022
adherens junction organization GO:0034332 4 0.022
negative regulation of response to stimulus GO:0048585 104 0.022
spindle localization GO:0051653 12 0.022
retina morphogenesis in camera type eye GO:0060042 79 0.022
positive regulation of metabolic process GO:0009893 108 0.022
negative regulation of signal transduction GO:0009968 94 0.022
cellular protein catabolic process GO:0044257 4 0.021
single organism localization GO:1902578 225 0.021
heart morphogenesis GO:0003007 156 0.021
cellular response to external stimulus GO:0071496 2 0.021
cell cycle GO:0007049 93 0.021
embryonic hemopoiesis GO:0035162 53 0.021
gamete generation GO:0007276 33 0.021
regulation of molecular function GO:0065009 70 0.021
regulation of synapse organization GO:0050807 3 0.021
anterior posterior pattern specification GO:0009952 152 0.020
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.020
regulation of stem cell differentiation GO:2000736 4 0.020
endodermal cell fate specification GO:0001714 17 0.020
regulation of cytokine production GO:0001817 3 0.020
guanosine containing compound metabolic process GO:1901068 4 0.020
establishment of spindle orientation GO:0051294 10 0.020
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.020
protein phosphorylation GO:0006468 47 0.020
nuclear import GO:0051170 3 0.020
small molecule metabolic process GO:0044281 77 0.020
diencephalon development GO:0021536 58 0.019
neuroblast proliferation GO:0007405 2 0.019
regulation of cell activation GO:0050865 1 0.019
determination of bilateral symmetry GO:0009855 204 0.019
regulation of dna replication GO:0006275 3 0.019
epidermis development GO:0008544 48 0.019
regulation of meiotic cell cycle GO:0051445 1 0.019
cellular carbohydrate metabolic process GO:0044262 4 0.019
actin filament based process GO:0030029 64 0.019
cell projection organization GO:0030030 284 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
specification of symmetry GO:0009799 204 0.019
transcription from rna polymerase ii promoter GO:0006366 80 0.019
synaptic target recognition GO:0008039 1 0.019
negative regulation of multicellular organismal process GO:0051241 69 0.019
negative regulation of gene expression GO:0010629 65 0.019
cell proliferation GO:0008283 80 0.019
chemotaxis GO:0006935 104 0.019
cellular response to extracellular stimulus GO:0031668 2 0.019
cellular response to starvation GO:0009267 1 0.019
intracellular signal transduction GO:0035556 85 0.019
phosphate containing compound metabolic process GO:0006796 108 0.019
gtp catabolic process GO:0006184 2 0.019
cellular amine metabolic process GO:0044106 2 0.018
response to monosaccharide GO:0034284 3 0.018
regulation of cellular metabolic process GO:0031323 320 0.018
regulation of protein transport GO:0051223 3 0.018
response to glucose GO:0009749 3 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
positive regulation of glucose transport GO:0010828 1 0.018
guanosine containing compound catabolic process GO:1901069 2 0.018
cell migration GO:0016477 237 0.018
system process GO:0003008 185 0.018
camera type eye morphogenesis GO:0048593 108 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
cellular response to nutrient levels GO:0031669 2 0.017
skin development GO:0043588 54 0.017
single organism metabolic process GO:0044710 217 0.017
developmental growth GO:0048589 166 0.017
nucleic acid templated transcription GO:0097659 181 0.017
regulation of organ growth GO:0046620 3 0.017
negative regulation of metabolic process GO:0009892 86 0.017
response to vitamin GO:0033273 3 0.017
cellular aromatic compound metabolic process GO:0006725 295 0.017
regulation of response to cytokine stimulus GO:0060759 3 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
amine metabolic process GO:0009308 2 0.017
neuron projection development GO:0031175 180 0.017
organelle localization GO:0051640 49 0.017
nuclear export GO:0051168 1 0.017
positive regulation of carbohydrate metabolic process GO:0045913 1 0.017
regeneration GO:0031099 91 0.016
negative regulation of reproductive process GO:2000242 3 0.016
cell substrate adhesion GO:0031589 4 0.016
negative regulation of response to cytokine stimulus GO:0060761 2 0.016
negative chemotaxis GO:0050919 1 0.016
protein kinase b signaling GO:0043491 9 0.016
regulation of sodium ion transport GO:0002028 2 0.016
enzyme linked receptor protein signaling pathway GO:0007167 106 0.016
positive regulation of cellular component biogenesis GO:0044089 3 0.015
regulation of cellular amine metabolic process GO:0033238 0 0.015
activation of mapk activity GO:0000187 3 0.015
proteasomal protein catabolic process GO:0010498 2 0.015
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.015
circadian sleep wake cycle process GO:0022410 2 0.015
cell cycle g1 s phase transition GO:0044843 1 0.015
response to wounding GO:0009611 116 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.015
response to hexose GO:0009746 3 0.015
negative regulation of ras protein signal transduction GO:0046580 1 0.015
phosphorus metabolic process GO:0006793 109 0.015
cell morphogenesis GO:0000902 289 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.015
regulation of reproductive process GO:2000241 4 0.015
phosphorylation GO:0016310 69 0.015
reactive nitrogen species metabolic process GO:2001057 0 0.015
cytoskeleton organization GO:0007010 96 0.015
negative regulation of developmental process GO:0051093 65 0.015
macromolecular complex subunit organization GO:0043933 74 0.015
protein import GO:0017038 3 0.015
cell projection morphogenesis GO:0048858 244 0.014
positive regulation of reproductive process GO:2000243 2 0.014
meiotic nuclear division GO:0007126 4 0.014
inner ear development GO:0048839 126 0.014
axon guidance GO:0007411 86 0.014
blood vessel morphogenesis GO:0048514 216 0.014
cell fate commitment GO:0045165 99 0.014
regulation of nucleoside metabolic process GO:0009118 2 0.014
protein localization to nucleus GO:0034504 3 0.014
response to drug GO:0042493 3 0.014
neuron differentiation GO:0030182 353 0.014
photoreceptor cell differentiation GO:0046530 55 0.014
myotube differentiation GO:0014902 45 0.014
regulation of intracellular signal transduction GO:1902531 57 0.014
g1 s transition of mitotic cell cycle GO:0000082 1 0.014
positive regulation of gtpase activity GO:0043547 1 0.014
regulation of circadian rhythm GO:0042752 4 0.014
regulation of cytoplasmic transport GO:1903649 4 0.014
protein complex subunit organization GO:0071822 46 0.014
regulation of nervous system development GO:0051960 90 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.014
establishment of spindle localization GO:0051293 12 0.014
cell matrix adhesion GO:0007160 4 0.013
renal system development GO:0072001 94 0.013
somatic stem cell maintenance GO:0035019 1 0.013
lamellipodium assembly GO:0030032 1 0.013
positive regulation of cell activation GO:0050867 1 0.013
regulation of cell development GO:0060284 100 0.013
protein targeting to nucleus GO:0044744 3 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
gtp metabolic process GO:0046039 4 0.013
multi organism process GO:0051704 134 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
centrosome cycle GO:0007098 1 0.013
regulation of gtp catabolic process GO:0033124 2 0.013
blood vessel development GO:0001568 246 0.013
photoreceptor cell outer segment organization GO:0035845 9 0.013
nitric oxide biosynthetic process GO:0006809 2 0.013
positive regulation of blood circulation GO:1903524 2 0.013
response to light stimulus GO:0009416 46 0.013
determination of left right symmetry GO:0007368 179 0.013
sex determination GO:0007530 1 0.013
striated muscle cell development GO:0055002 108 0.013
negative regulation of macromolecule metabolic process GO:0010605 76 0.013
adult behavior GO:0030534 2 0.013
regulation of mrna processing GO:0050684 3 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.013
mitotic cell cycle process GO:1903047 48 0.013
regulation of glucose transport GO:0010827 1 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.013
negative regulation of cytokine production GO:0001818 1 0.013
regulation of cellular protein metabolic process GO:0032268 52 0.013
positive regulation of jun kinase activity GO:0043507 2 0.013
epithelial tube morphogenesis GO:0060562 148 0.013
positive regulation of notch signaling pathway GO:0045747 3 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
protein import into nucleus GO:0006606 3 0.012
synaptic growth at neuromuscular junction GO:0051124 2 0.012
negative regulation of kinase activity GO:0033673 4 0.012
regulation of cell cycle GO:0051726 52 0.012
growth GO:0040007 174 0.012
positive regulation of secretion GO:0051047 1 0.012
circadian sleep wake cycle GO:0042745 2 0.012
cellular ketone metabolic process GO:0042180 11 0.012
microtubule cytoskeleton organization GO:0000226 33 0.012
regulation of protein modification process GO:0031399 29 0.012
negative regulation of nucleic acid templated transcription GO:1903507 45 0.012
pyruvate metabolic process GO:0006090 1 0.012
response to organic substance GO:0010033 153 0.012
organonitrogen compound metabolic process GO:1901564 74 0.012
single organism cellular localization GO:1902580 46 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.012
rna localization GO:0006403 4 0.012
circadian sleep wake cycle sleep GO:0050802 1 0.012
chordate embryonic development GO:0043009 271 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
atp catabolic process GO:0006200 4 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
convergent extension GO:0060026 118 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
epithelial cell differentiation GO:0030855 116 0.012
cell aging GO:0007569 2 0.011
female sex differentiation GO:0046660 4 0.011
positive regulation of molecular function GO:0044093 33 0.011
muscle cell differentiation GO:0042692 139 0.011
wound healing GO:0042060 90 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
regulation of smoothened signaling pathway GO:0008589 18 0.011
cartilage development GO:0051216 96 0.011
positive regulation of catalytic activity GO:0043085 25 0.011
centrosome organization GO:0051297 1 0.011
positive regulation of cellular biosynthetic process GO:0031328 68 0.011
neurotransmitter secretion GO:0007269 2 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
regulation of phosphate metabolic process GO:0019220 43 0.011
cellular response to stress GO:0033554 62 0.011
embryonic skeletal system morphogenesis GO:0048704 93 0.011
striated muscle cell differentiation GO:0051146 129 0.011
inositol lipid mediated signaling GO:0048017 2 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
regulation of response to nutrient levels GO:0032107 1 0.011
stem cell development GO:0048864 82 0.011
embryonic skeletal system development GO:0048706 97 0.011
ear development GO:0043583 127 0.011
cellular response to organic substance GO:0071310 105 0.011
establishment or maintenance of cell polarity GO:0007163 29 0.011
formation of primary germ layer GO:0001704 62 0.011
positive regulation of signal transduction GO:0009967 56 0.011
regulation of skeletal muscle tissue development GO:0048641 4 0.011
regulation of cell differentiation GO:0045595 142 0.011
developmental maturation GO:0021700 34 0.011
pancreas development GO:0031016 84 0.011
protein secretion GO:0009306 1 0.011
regulation of protein ubiquitination GO:0031396 3 0.010
negative regulation of multi organism process GO:0043901 3 0.010
embryonic heart tube development GO:0035050 133 0.010
cellular response to endogenous stimulus GO:0071495 68 0.010
positive regulation of protein polymerization GO:0032273 2 0.010
regulation of metal ion transport GO:0010959 4 0.010
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.010
positive regulation of cell adhesion GO:0045785 1 0.010
protein acylation GO:0043543 3 0.010
regulation of nucleocytoplasmic transport GO:0046822 2 0.010
wnt signaling pathway GO:0016055 80 0.010
positive regulation of biological process GO:0048518 253 0.010
hypothalamus cell differentiation GO:0021979 4 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
death GO:0016265 121 0.010
positive regulation of apoptotic signaling pathway GO:2001235 1 0.010
establishment of mitotic spindle localization GO:0040001 12 0.010
cellular response to organic cyclic compound GO:0071407 38 0.010
negative regulation of stem cell differentiation GO:2000737 2 0.010
negative regulation of synapse assembly GO:0051964 2 0.010
forebrain development GO:0030900 96 0.010

rapgef1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.015