Danio rerio

15 known processes

rbb4

retinoblastoma binding protein 4

(Aliases: rbb4-2,wu:fb33a09,wu:fb40e10,RBBP4,zgc:55349,zgc:77854)

rbb4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
methylation GO:0032259 22 0.549
Fly
internal peptidyl lysine acetylation GO:0018393 2 0.488
Yeast Fly
heterocycle metabolic process GO:0046483 290 0.445
Human Yeast Fly
nucleobase containing compound metabolic process GO:0006139 274 0.333
Human Yeast Fly
cellular aromatic compound metabolic process GO:0006725 295 0.325
Human Yeast Fly
digestive tract development GO:0048565 265 0.325
Worm
nitrogen compound metabolic process GO:0006807 319 0.320
Human Yeast Fly
negative regulation of biological process GO:0048519 304 0.318
Yeast Worm Fly
regulation of macromolecule metabolic process GO:0060255 317 0.318
Yeast Worm Fly
protein modification process GO:0036211 100 0.314
Yeast Fly
regulation of mitotic cell cycle GO:0007346 25 0.309
Fly
double strand break repair GO:0006302 3 0.307
negative regulation of ras protein signal transduction GO:0046580 1 0.297
internal protein amino acid acetylation GO:0006475 2 0.265
Yeast Fly
protein acylation GO:0043543 3 0.251
Yeast Fly
negative regulation of cellular process GO:0048523 283 0.243
Yeast Fly
regulation of biological quality GO:0065008 263 0.238
mitotic cell cycle GO:0000278 64 0.230
Fly
peptidyl lysine acetylation GO:0018394 2 0.228
Yeast Fly
histone modification GO:0016570 20 0.227
Yeast Fly
reproduction GO:0000003 40 0.226
Worm
cellular macromolecule metabolic process GO:0044260 391 0.220
Human Yeast Fly
negative regulation of signal transduction GO:0009968 94 0.210
organic cyclic compound biosynthetic process GO:1901362 223 0.208
Yeast Fly
g1 s transition of mitotic cell cycle GO:0000082 1 0.207
protein metabolic process GO:0019538 183 0.202
Yeast Fly
protein acetylation GO:0006473 2 0.199
Yeast Fly
rna metabolic process GO:0016070 219 0.190
Yeast Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.187
Yeast Fly
programmed cell death GO:0012501 119 0.185
Worm
organelle organization GO:0006996 227 0.184
Human Yeast Fly
response to stress GO:0006950 263 0.180
cellular protein metabolic process GO:0044267 129 0.179
Yeast Fly
cellular component movement GO:0006928 335 0.176
protein alkylation GO:0008213 13 0.173
Fly
negative regulation of signaling GO:0023057 96 0.166
cell cycle process GO:0022402 53 0.161
Fly
cellular protein modification process GO:0006464 100 0.159
Yeast Fly
regulation of gene expression GO:0010468 265 0.158
Yeast Worm Fly
chromosome organization GO:0051276 31 0.157
Human Yeast Fly
single organism organelle organization GO:1902589 199 0.157
Yeast Fly
organic substance biosynthetic process GO:1901576 289 0.156
Yeast Fly
death GO:0016265 121 0.154
Worm
nuclear migration GO:0007097 3 0.151
nucleic acid templated transcription GO:0097659 181 0.148
Yeast Fly
single fertilization GO:0007338 3 0.140
cell death GO:0008219 121 0.137
Worm
cell cycle GO:0007049 93 0.134
Fly
apoptotic process GO:0006915 116 0.130
Worm
cellular macromolecule biosynthetic process GO:0034645 224 0.128
Yeast Fly
covalent chromatin modification GO:0016569 20 0.125
Yeast Fly
heterocycle biosynthetic process GO:0018130 215 0.125
Yeast Fly
regulation of primary metabolic process GO:0080090 311 0.122
Yeast Fly
regulation of cellular metabolic process GO:0031323 320 0.120
Yeast Fly
biosynthetic process GO:0009058 294 0.119
Yeast Fly
nucleic acid metabolic process GO:0090304 244 0.117
Human Yeast Fly
positive regulation of cell cycle GO:0045787 3 0.117
positive regulation of dna metabolic process GO:0051054 1 0.115
tube morphogenesis GO:0035239 349 0.114
Worm
gene expression GO:0010467 252 0.112
Yeast Worm Fly
digestive tract morphogenesis GO:0048546 231 0.106
Worm
macromolecule modification GO:0043412 111 0.105
Yeast Fly
digestive system development GO:0055123 289 0.104
Worm
aging GO:0007568 2 0.102
regulation of apoptotic process GO:0042981 98 0.101
regulation of transcription dna templated GO:0006355 213 0.094
Yeast Fly
recombinational repair GO:0000725 1 0.092
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.091
Yeast Fly
determination of bilateral symmetry GO:0009855 204 0.090
cell projection morphogenesis GO:0048858 244 0.090
Fly
macromolecule biosynthetic process GO:0009059 227 0.089
Yeast Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.089
Yeast Fly
cell migration GO:0016477 237 0.089
regulation of programmed cell death GO:0043067 101 0.087
cell projection organization GO:0030030 284 0.087
Fly
dna modification GO:0006304 8 0.086
developmental growth GO:0048589 166 0.085
regulation of cell death GO:0010941 103 0.085
sexual reproduction GO:0019953 36 0.085
negative regulation of cell death GO:0060548 60 0.084
nucleobase containing compound biosynthetic process GO:0034654 205 0.084
Yeast Fly
regulation of rna metabolic process GO:0051252 224 0.082
Yeast Fly
regulation of multicellular organismal process GO:0051239 277 0.080
Worm
cell cycle g1 s phase transition GO:0044843 1 0.080
mitotic recombination GO:0006312 2 0.079
behavior GO:0007610 74 0.078
muscle structure development GO:0061061 196 0.078
Fly
blood vessel morphogenesis GO:0048514 216 0.078
positive regulation of transport GO:0051050 2 0.076
regulation of nucleic acid templated transcription GO:1903506 213 0.075
Yeast Fly
neuron projection development GO:0031175 180 0.074
Fly
negative regulation of programmed cell death GO:0043069 58 0.074
positive regulation of chromatin modification GO:1903310 1 0.072
angiogenesis GO:0001525 158 0.071
nuclear division GO:0000280 23 0.070
developmental process involved in reproduction GO:0003006 27 0.070
Worm
macromolecule methylation GO:0043414 19 0.070
Fly
dna metabolic process GO:0006259 27 0.069
Human Yeast Fly
cell cycle g2 m phase transition GO:0044839 4 0.069
immune system process GO:0002376 241 0.068
protein methylation GO:0006479 13 0.068
Fly
localization of cell GO:0051674 244 0.067
rna stabilization GO:0043489 4 0.066
mitotic cell cycle process GO:1903047 48 0.066
Fly
multi organism process GO:0051704 134 0.065
negative regulation of apoptotic process GO:0043066 55 0.065
negative regulation of cell communication GO:0010648 96 0.065
mitotic cell cycle phase transition GO:0044772 9 0.064
embryo development ending in birth or egg hatching GO:0009792 271 0.064
Worm
cellular carbohydrate metabolic process GO:0044262 4 0.063
aromatic compound biosynthetic process GO:0019438 217 0.062
Yeast Fly
establishment of localization GO:0051234 244 0.061
locomotion GO:0040011 313 0.060
Worm
lateral inhibition GO:0046331 1 0.060
response to chemical GO:0042221 320 0.059
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.058
regeneration GO:0031099 91 0.058
head development GO:0060322 303 0.058
fertilization GO:0009566 3 0.057
regulation of cellular biosynthetic process GO:0031326 245 0.057
Yeast Fly
telomere organization GO:0032200 1 0.057
multi organism reproductive process GO:0044703 36 0.056
mitotic dna damage checkpoint GO:0044773 4 0.056
rna biosynthetic process GO:0032774 181 0.055
Yeast Fly
organic cyclic compound metabolic process GO:1901360 301 0.053
Human Yeast Fly
larval development GO:0002164 2 0.052
Worm
homeostatic process GO:0042592 142 0.050
cellular nitrogen compound metabolic process GO:0034641 290 0.049
Human Yeast Fly
cellular amine metabolic process GO:0044106 2 0.048
mitotic g2 dna damage checkpoint GO:0007095 3 0.048
regulation of cell cycle process GO:0010564 20 0.048
double strand break repair via nonhomologous end joining GO:0006303 1 0.047
histone methylation GO:0016571 13 0.046
Fly
regulation of mrna stability GO:0043488 4 0.046
double strand break repair via homologous recombination GO:0000724 1 0.046
protein complex localization GO:0031503 1 0.044
cellular ketone metabolic process GO:0042180 11 0.044
non recombinational repair GO:0000726 2 0.044
cellular response to external stimulus GO:0071496 2 0.043
negative regulation of response to stimulus GO:0048585 104 0.042
neuron differentiation GO:0030182 353 0.042
Fly
transport GO:0006810 220 0.042
mitotic dna integrity checkpoint GO:0044774 4 0.041
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.041
Yeast Fly
regulation of cellular amine metabolic process GO:0033238 0 0.041
astrocyte differentiation GO:0048708 1 0.040
regulation of metabolic process GO:0019222 359 0.040
Yeast Worm Fly
epithelial tube morphogenesis GO:0060562 148 0.040
positive regulation of biological process GO:0048518 253 0.039
Fly
cellular component morphogenesis GO:0032989 336 0.039
Fly
regulation of developmental process GO:0050793 247 0.039
Worm
cytokinesis GO:0000910 3 0.038
Fly
regulation of cellular ketone metabolic process GO:0010565 7 0.038
positive regulation of cellular amine metabolic process GO:0033240 0 0.038
cellular component disassembly GO:0022411 1 0.037
vasculature development GO:0001944 278 0.037
determination of left right symmetry GO:0007368 179 0.037
tissue regeneration GO:0042246 74 0.036
specification of symmetry GO:0009799 204 0.036
gene silencing GO:0016458 4 0.036
Yeast Worm Fly
adult behavior GO:0030534 2 0.035
g2 m transition of mitotic cell cycle GO:0000086 4 0.035
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.035
negative regulation of cell cycle GO:0045786 14 0.035
cellular biosynthetic process GO:0044249 286 0.034
Yeast Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.034
Yeast Fly
negative regulation of cell cycle phase transition GO:1901988 5 0.034
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.034
Yeast Fly
mitotic g2 m transition checkpoint GO:0044818 3 0.034
cellular response to stress GO:0033554 62 0.033
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.033
single organism localization GO:1902578 225 0.033
intracellular signal transduction GO:0035556 85 0.033
amine metabolic process GO:0009308 2 0.032
telomere maintenance GO:0000723 1 0.032
peptidyl amino acid modification GO:0018193 16 0.032
Yeast Fly
signal transduction GO:0007165 455 0.031
response to organic substance GO:0010033 153 0.031
oxoacid metabolic process GO:0043436 31 0.031
negative regulation of developmental process GO:0051093 65 0.031
Worm
muscle tissue development GO:0060537 110 0.031
regulation of molecular function GO:0065009 70 0.031
gamete generation GO:0007276 33 0.030
positive regulation of carbohydrate metabolic process GO:0045913 1 0.030
multicellular organism growth GO:0035264 4 0.030
regulation of signal transduction GO:0009966 225 0.029
heart development GO:0007507 313 0.029
regulation of establishment of protein localization GO:0070201 4 0.029
negative regulation of rna biosynthetic process GO:1902679 45 0.028
Yeast Fly
convergent extension GO:0060026 118 0.028
regulation of cellular protein metabolic process GO:0032268 52 0.028
cell motility GO:0048870 244 0.028
macromolecular complex subunit organization GO:0043933 74 0.028
Human Yeast Fly
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
taxis GO:0042330 109 0.028
protein polymerization GO:0051258 4 0.028
negative regulation of cellular metabolic process GO:0031324 77 0.028
Yeast Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.027
Yeast Fly
blood vessel development GO:0001568 246 0.027
regulation of biosynthetic process GO:0009889 250 0.027
Yeast Fly
positive regulation of metabolic process GO:0009893 108 0.027
cellular protein complex localization GO:0034629 1 0.027
dna catabolic process GO:0006308 1 0.027
female gamete generation GO:0007292 14 0.027
regulation of signaling GO:0023051 235 0.026
negative regulation of cellular biosynthetic process GO:0031327 55 0.026
Yeast Fly
regulation of mitotic cell cycle phase transition GO:1901990 8 0.026
hemopoiesis GO:0030097 183 0.026
transcription dna templated GO:0006351 181 0.026
Yeast Fly
organonitrogen compound metabolic process GO:1901564 74 0.025
Human
fin regeneration GO:0031101 51 0.025
regulation of glial cell differentiation GO:0045685 4 0.024
response to external stimulus GO:0009605 264 0.024
brain development GO:0007420 293 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.024
cell part morphogenesis GO:0032990 246 0.024
Fly
cell morphogenesis GO:0000902 289 0.024
Fly
negative regulation of nucleic acid templated transcription GO:1903507 45 0.024
Yeast Fly
regulation of cell cycle GO:0051726 52 0.024
Fly
regulation of cell differentiation GO:0045595 142 0.024
posttranscriptional gene silencing by rna GO:0035194 3 0.024
Worm
regulation of anatomical structure morphogenesis GO:0022603 130 0.023
cytoskeleton dependent cytokinesis GO:0061640 3 0.023
Fly
regulation of rna biosynthetic process GO:2001141 213 0.023
Yeast Fly
eye development GO:0001654 277 0.023
regulation of response to stimulus GO:0048583 269 0.023
morphogenesis of an epithelium GO:0002009 333 0.022
response to corticosteroid GO:0031960 1 0.022
carboxylic acid metabolic process GO:0019752 22 0.022
maintenance of location GO:0051235 4 0.022
positive regulation of cellular metabolic process GO:0031325 94 0.022
macromolecular complex disassembly GO:0032984 1 0.022
response to drug GO:0042493 3 0.022
chromatin modification GO:0016568 21 0.021
Human Yeast Fly
regulation of multicellular organism growth GO:0040014 4 0.021
cellular component biogenesis GO:0044085 178 0.021
Human Yeast Fly
camera type eye development GO:0043010 222 0.021
pronuclear migration GO:0035046 1 0.021
positive regulation of translation GO:0045727 1 0.021
positive regulation of histone modification GO:0031058 1 0.021
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.020
Fly
dna biosynthetic process GO:0071897 3 0.020
multicellular organism reproduction GO:0032504 35 0.020
meiotic nuclear division GO:0007126 4 0.020
organic acid metabolic process GO:0006082 31 0.020
striated muscle tissue development GO:0014706 110 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.020
Yeast Fly
cell surface receptor signaling pathway GO:0007166 325 0.020
regulation of vasculature development GO:1901342 33 0.020
meiotic cell cycle process GO:1903046 3 0.020
mitotic nuclear division GO:0007067 18 0.019
dna methylation or demethylation GO:0044728 8 0.019
regulation of response to stress GO:0080134 36 0.019
regulation of growth GO:0040008 42 0.019
dorsal ventral pattern formation GO:0009953 125 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.019
immune system development GO:0002520 191 0.019
single organism metabolic process GO:0044710 217 0.019
Human Yeast Fly
carbohydrate biosynthetic process GO:0016051 1 0.019
embryonic digestive tract morphogenesis GO:0048557 3 0.018
Worm
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.018
regulation of intracellular protein transport GO:0033157 3 0.018
regulation of dna recombination GO:0000018 2 0.018
hematopoietic or lymphoid organ development GO:0048534 191 0.018
nuclear transport GO:0051169 4 0.018
negative regulation of gene expression GO:0010629 65 0.018
Yeast Worm Fly
establishment of localization in cell GO:0051649 77 0.018
single organism biosynthetic process GO:0044711 71 0.017
regulation of cellular component organization GO:0051128 86 0.017
anterior posterior pattern specification GO:0009952 152 0.017
gene silencing by rna GO:0031047 4 0.017
Worm
regulation of intracellular signal transduction GO:1902531 57 0.017
negative regulation of intracellular signal transduction GO:1902532 22 0.017
regulation of microtubule cytoskeleton organization GO:0070507 3 0.017
gastrulation GO:0007369 208 0.017
positive regulation of cellular process GO:0048522 201 0.017
Fly
small molecule metabolic process GO:0044281 77 0.017
Human
cell cycle phase transition GO:0044770 9 0.017
actin filament polymerization GO:0030041 2 0.017
reciprocal meiotic recombination GO:0007131 1 0.017
system process GO:0003008 185 0.016
macromolecular complex assembly GO:0065003 35 0.016
Human Yeast Fly
adherens junction assembly GO:0034333 1 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
histone deacetylation GO:0016575 2 0.016
regulation of cell communication GO:0010646 232 0.016
generation of neurons GO:0048699 385 0.016
Fly
regulation of chromosome segregation GO:0051983 1 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.016
neuron development GO:0048666 262 0.016
Fly
energy reserve metabolic process GO:0006112 2 0.016
negative regulation of dna metabolic process GO:0051053 4 0.016
small gtpase mediated signal transduction GO:0007264 8 0.016
establishment or maintenance of cell polarity GO:0007163 29 0.016
reciprocal dna recombination GO:0035825 1 0.016
regulation of protein transport GO:0051223 3 0.015
regionalization GO:0003002 274 0.015
Fly
positive regulation of biosynthetic process GO:0009891 68 0.015
regulation of cellular response to stress GO:0080135 20 0.015
negative regulation of macromolecule metabolic process GO:0010605 76 0.015
Yeast Worm Fly
protein stabilization GO:0050821 2 0.014
cellular component assembly GO:0022607 170 0.014
Human Yeast Fly
ribonucleoside monophosphate catabolic process GO:0009158 4 0.014
Human
regulation of gene expression epigenetic GO:0040029 11 0.014
Yeast Worm Fly
ras protein signal transduction GO:0007265 7 0.014
organelle assembly GO:0070925 110 0.014
macromolecule catabolic process GO:0009057 15 0.014
response to glucocorticoid GO:0051384 1 0.014
negative regulation of transcription dna templated GO:0045892 45 0.014
Yeast Fly
positive regulation of multicellular organismal process GO:0051240 52 0.014
spindle assembly GO:0051225 2 0.014
central nervous system development GO:0007417 387 0.014
peptidyl lysine modification GO:0018205 5 0.014
Yeast Fly
muscle cell development GO:0055001 115 0.014
cellular response to organic cyclic compound GO:0071407 38 0.014
interspecies interaction between organisms GO:0044419 4 0.014
organelle fission GO:0048285 23 0.014
growth GO:0040007 174 0.014
regulation of multicellular organismal development GO:2000026 223 0.014
Worm
chemotaxis GO:0006935 104 0.014
retinal cell programmed cell death GO:0046666 2 0.014
protein dephosphorylation GO:0006470 3 0.013
protein localization GO:0008104 40 0.013
regulation of cell development GO:0060284 100 0.013
organ regeneration GO:0031100 1 0.013
cell aging GO:0007569 2 0.013
multi organism cellular process GO:0044764 2 0.013
meiosis i GO:0007127 1 0.013
dna integrity checkpoint GO:0031570 6 0.013
regulation of canonical wnt signaling pathway GO:0060828 34 0.013
cell proliferation GO:0008283 80 0.013
Fly
skeletal muscle tissue development GO:0007519 67 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
Human
stem cell maintenance GO:0019827 4 0.013
hematopoietic stem cell homeostasis GO:0061484 2 0.013
phosphorus metabolic process GO:0006793 109 0.013
Human
mitotic metaphase plate congression GO:0007080 1 0.012
spermatid differentiation GO:0048515 2 0.012
histone h3 k4 methylation GO:0051568 2 0.012
regulation of organelle organization GO:0033043 29 0.012
cellular localization GO:0051641 97 0.012
cellular response to organic substance GO:0071310 105 0.012
spermatid development GO:0007286 2 0.012
negative regulation of biosynthetic process GO:0009890 55 0.012
Yeast Fly
phosphorylation GO:0016310 69 0.012
positive regulation of cellular protein metabolic process GO:0032270 22 0.012
peptidyl lysine dimethylation GO:0018027 1 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
regulation of carbohydrate metabolic process GO:0006109 4 0.012
cell fate commitment GO:0045165 99 0.012
Worm
posttranscriptional regulation of gene expression GO:0010608 14 0.011
Worm
regulation of tube size GO:0035150 2 0.011
autophagy GO:0006914 4 0.011
positive regulation of cellular biosynthetic process GO:0031328 68 0.011
establishment of protein localization to organelle GO:0072594 4 0.011
convergent extension involved in gastrulation GO:0060027 71 0.011
negative regulation of rna metabolic process GO:0051253 48 0.011
Yeast Fly
regulation of response to oxidative stress GO:1902882 2 0.011
dna templated transcription initiation GO:0006352 1 0.011
positive regulation of chromosome organization GO:2001252 1 0.011
regulation of protein complex assembly GO:0043254 3 0.011
translational initiation GO:0006413 3 0.011
regulation of carbohydrate biosynthetic process GO:0043255 1 0.011
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
cellular response to extracellular stimulus GO:0031668 2 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
cellular protein complex assembly GO:0043623 19 0.011
negative regulation of cell cycle process GO:0010948 9 0.011
organic substance transport GO:0071702 58 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
Fly
regulation of cell cycle phase transition GO:1901987 8 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.010
single organism reproductive process GO:0044702 40 0.010
Worm
protein localization to nucleus GO:0034504 3 0.010
neural retina development GO:0003407 49 0.010
cell substrate adhesion GO:0031589 4 0.010

rbb4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.039
nervous system disease DOID:863 0 0.015
disease of mental health DOID:150 0 0.012
developmental disorder of mental health DOID:0060037 0 0.012