Danio rerio

58 known processes

rpgrb

retinitis pigmentosa GTPase regulator b

rpgrb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
renal system development GO:0072001 94 0.183
specification of symmetry GO:0009799 204 0.164
urogenital system development GO:0001655 97 0.153
heart development GO:0007507 313 0.147
embryonic organ development GO:0048568 381 0.131
positive regulation of biological process GO:0048518 253 0.130
eye development GO:0001654 277 0.116
morphogenesis of an epithelium GO:0002009 333 0.115
embryonic organ morphogenesis GO:0048562 274 0.113
sensory organ development GO:0007423 393 0.107
tube morphogenesis GO:0035239 349 0.097
signal transduction GO:0007165 455 0.097
heart looping GO:0001947 94 0.089
cellular biosynthetic process GO:0044249 286 0.086
determination of left right symmetry GO:0007368 179 0.086
somitogenesis GO:0001756 87 0.084
organic substance biosynthetic process GO:1901576 289 0.083
positive regulation of transport GO:0051050 2 0.072
muscle cell development GO:0055001 115 0.067
determination of heart left right asymmetry GO:0061371 117 0.067
regulation of signaling GO:0023051 235 0.067
embryonic heart tube morphogenesis GO:0003143 108 0.065
camera type eye development GO:0043010 222 0.065
response to chemical GO:0042221 320 0.064
determination of bilateral symmetry GO:0009855 204 0.063
striated muscle cell development GO:0055002 108 0.062
lipid storage GO:0019915 1 0.061
regulation of synapse organization GO:0050807 3 0.060
chordate embryonic development GO:0043009 271 0.060
regulation of establishment of protein localization GO:0070201 4 0.060
generation of neurons GO:0048699 385 0.058
biosynthetic process GO:0009058 294 0.056
skeletal system development GO:0001501 181 0.055
aging GO:0007568 2 0.054
negative regulation of cellular process GO:0048523 283 0.052
retina development in camera type eye GO:0060041 146 0.051
maintenance of location GO:0051235 4 0.051
inner ear development GO:0048839 126 0.051
rna biosynthetic process GO:0032774 181 0.050
brain development GO:0007420 293 0.050
regulation of macromolecule metabolic process GO:0060255 317 0.050
muscle cell differentiation GO:0042692 139 0.049
regulation of response to stimulus GO:0048583 269 0.048
regulation of primary metabolic process GO:0080090 311 0.047
nucleocytoplasmic transport GO:0006913 4 0.047
regulation of metabolic process GO:0019222 359 0.046
striated muscle tissue development GO:0014706 110 0.046
camera type eye morphogenesis GO:0048593 108 0.045
regulation of multicellular organismal process GO:0051239 277 0.044
epithelial tube morphogenesis GO:0060562 148 0.043
nucleobase containing compound metabolic process GO:0006139 274 0.043
heterocycle metabolic process GO:0046483 290 0.043
muscle tissue development GO:0060537 110 0.043
regulation of macromolecule biosynthetic process GO:0010556 225 0.042
regulation of cellular metabolic process GO:0031323 320 0.042
macromolecule biosynthetic process GO:0009059 227 0.041
multicellular organism growth GO:0035264 4 0.041
nitrogen compound metabolic process GO:0006807 319 0.041
regionalization GO:0003002 274 0.040
regulation of cell communication GO:0010646 232 0.040
protein localization to nucleus GO:0034504 3 0.040
neuron differentiation GO:0030182 353 0.040
cellular nitrogen compound metabolic process GO:0034641 290 0.039
embryonic heart tube development GO:0035050 133 0.039
positive regulation of catabolic process GO:0009896 4 0.039
organic cyclic compound biosynthetic process GO:1901362 223 0.038
cellular macromolecule metabolic process GO:0044260 391 0.038
negative regulation of biological process GO:0048519 304 0.037
appendage morphogenesis GO:0035107 56 0.037
pronephros development GO:0048793 69 0.037
single organism metabolic process GO:0044710 217 0.037
regulation of protein transport GO:0051223 3 0.035
photoreceptor cell differentiation GO:0046530 55 0.035
rna metabolic process GO:0016070 219 0.035
regulation of apoptotic process GO:0042981 98 0.034
striated muscle cell differentiation GO:0051146 129 0.034
central nervous system development GO:0007417 387 0.034
muscle structure development GO:0061061 196 0.034
blood vessel development GO:0001568 246 0.033
neuron development GO:0048666 262 0.031
response to carbohydrate GO:0009743 3 0.030
amine metabolic process GO:0009308 2 0.030
stem cell maintenance GO:0019827 4 0.029
nuclear import GO:0051170 3 0.029
regulation of cellular amine metabolic process GO:0033238 0 0.029
organic cyclic compound metabolic process GO:1901360 301 0.029
cellular response to external stimulus GO:0071496 2 0.029
regulation of protein targeting GO:1903533 2 0.029
larval development GO:0002164 2 0.028
nucleic acid metabolic process GO:0090304 244 0.028
vasculature development GO:0001944 278 0.028
heart morphogenesis GO:0003007 156 0.028
fat soluble vitamin metabolic process GO:0006775 4 0.027
regulation of cell death GO:0010941 103 0.027
response to stress GO:0006950 263 0.027
cellular amine metabolic process GO:0044106 2 0.027
cellular protein catabolic process GO:0044257 4 0.027
cellular component assembly GO:0022607 170 0.027
regulation of cytoplasmic transport GO:1903649 4 0.027
developmental growth GO:0048589 166 0.027
regulation of signal transduction GO:0009966 225 0.027
fin development GO:0033333 77 0.027
regulation of biosynthetic process GO:0009889 250 0.026
protein targeting to nucleus GO:0044744 3 0.026
regulation of multicellular organismal development GO:2000026 223 0.026
ear development GO:0043583 127 0.026
positive regulation of cellular catabolic process GO:0031331 3 0.026
regulation of protein complex assembly GO:0043254 3 0.026
cellular modified amino acid metabolic process GO:0006575 3 0.026
cell matrix adhesion GO:0007160 4 0.025
positive regulation of cellular component biogenesis GO:0044089 3 0.025
digestive tract morphogenesis GO:0048546 231 0.025
regulation of muscle contraction GO:0006937 3 0.025
regulation of nucleocytoplasmic transport GO:0046822 2 0.025
modification dependent macromolecule catabolic process GO:0043632 3 0.025
adult behavior GO:0030534 2 0.025
exocytosis GO:0006887 1 0.025
mitochondrion organization GO:0007005 4 0.025
nuclear transport GO:0051169 4 0.025
ear morphogenesis GO:0042471 64 0.025
cellular aromatic compound metabolic process GO:0006725 295 0.025
single organism nuclear import GO:1902593 3 0.025
protein metabolic process GO:0019538 183 0.025
regulation of reproductive process GO:2000241 4 0.024
eye photoreceptor cell differentiation GO:0001754 45 0.024
response to vitamin GO:0033273 3 0.024
regulation of developmental process GO:0050793 247 0.024
somite development GO:0061053 96 0.024
modification dependent protein catabolic process GO:0019941 3 0.024
nucleobase containing compound biosynthetic process GO:0034654 205 0.024
regulation of nitrogen compound metabolic process GO:0051171 251 0.024
regulation of protein localization to nucleus GO:1900180 2 0.024
oocyte maturation GO:0001556 4 0.024
heterocycle biosynthetic process GO:0018130 215 0.023
protein import into nucleus GO:0006606 3 0.023
regulation of protein import into nucleus GO:0042306 2 0.023
death GO:0016265 121 0.023
cognition GO:0050890 1 0.023
cell substrate adhesion GO:0031589 4 0.023
gene expression GO:0010467 252 0.023
establishment of localization GO:0051234 244 0.023
Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.022
negative regulation of protein phosphorylation GO:0001933 4 0.022
cell projection organization GO:0030030 284 0.022
regulation of cellular biosynthetic process GO:0031326 245 0.022
nucleic acid templated transcription GO:0097659 181 0.022
transcription from rna polymerase ii promoter GO:0006366 80 0.022
regulation of multicellular organism growth GO:0040014 4 0.022
nucleoside monophosphate catabolic process GO:0009125 4 0.021
digestive system development GO:0055123 289 0.021
regulation of nucleic acid templated transcription GO:1903506 213 0.021
proteasomal protein catabolic process GO:0010498 2 0.021
cellular component biogenesis GO:0044085 178 0.021
cell death GO:0008219 121 0.021
response to external stimulus GO:0009605 264 0.021
positive regulation of secretion by cell GO:1903532 1 0.020
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.020
appendage development GO:0048736 80 0.020
regulation of rna metabolic process GO:0051252 224 0.020
adherens junction organization GO:0034332 4 0.020
sensory organ morphogenesis GO:0090596 200 0.020
regulation of gene expression GO:0010468 265 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
aromatic compound biosynthetic process GO:0019438 217 0.020
cell part morphogenesis GO:0032990 246 0.020
ubiquitin dependent protein catabolic process GO:0006511 3 0.020
anterior posterior pattern specification GO:0009952 152 0.020
protein import GO:0017038 3 0.020
locomotion GO:0040011 313 0.019
head development GO:0060322 303 0.019
retina morphogenesis in camera type eye GO:0060042 79 0.019
ribonucleoside monophosphate catabolic process GO:0009158 4 0.019
stem cell development GO:0048864 82 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.019
regulation of cell development GO:0060284 100 0.018
regulation of programmed cell death GO:0043067 101 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
alternative mrna splicing via spliceosome GO:0000380 1 0.018
oxoacid metabolic process GO:0043436 31 0.018
meiotic nuclear division GO:0007126 4 0.018
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.018
regulation of synaptic plasticity GO:0048167 1 0.018
xenobiotic metabolic process GO:0006805 4 0.018
regulation of cellular amino acid metabolic process GO:0006521 0 0.018
positive regulation of nucleoside metabolic process GO:0045979 1 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.017
cell surface receptor signaling pathway GO:0007166 325 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
embryonic skeletal system development GO:0048706 97 0.017
muscle organ development GO:0007517 101 0.017
water homeostasis GO:0030104 4 0.017
protein glycosylation GO:0006486 9 0.017
cellular localization GO:0051641 97 0.017
Mouse
cellular response to extracellular stimulus GO:0031668 2 0.017
positive regulation of secretion GO:0051047 1 0.017
regulation of synapse assembly GO:0051963 3 0.017
regulation of transmembrane transporter activity GO:0022898 2 0.017
positive regulation of metabolic process GO:0009893 108 0.017
interspecies interaction between organisms GO:0044419 4 0.017
germ line stem cell maintenance GO:0030718 2 0.017
negative regulation of macromolecule metabolic process GO:0010605 76 0.017
negative regulation of cellular catabolic process GO:0031330 3 0.017
response to nutrient GO:0007584 3 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.017
programmed cell death GO:0012501 119 0.016
negative regulation of cytoplasmic transport GO:1903650 2 0.016
rna localization GO:0006403 4 0.016
pigmentation GO:0043473 85 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
regulation of protein catabolic process GO:0042176 1 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
positive regulation of cellular metabolic process GO:0031325 94 0.016
positive regulation of cytokine production GO:0001819 2 0.016
vitamin metabolic process GO:0006766 11 0.016
regulation of metal ion transport GO:0010959 4 0.016
regulation of neural precursor cell proliferation GO:2000177 3 0.016
cellular component movement GO:0006928 335 0.016
regulation of organelle assembly GO:1902115 4 0.016
organonitrogen compound metabolic process GO:1901564 74 0.016
inner ear morphogenesis GO:0042472 63 0.016
small molecule metabolic process GO:0044281 77 0.016
regulation of cellular protein catabolic process GO:1903362 1 0.016
response to glucose GO:0009749 3 0.016
membrane hyperpolarization GO:0060081 1 0.016
cellular ketone metabolic process GO:0042180 11 0.016
toll like receptor signaling pathway GO:0002224 4 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
epithelial cell differentiation GO:0030855 116 0.015
response to vitamin b3 GO:0033552 2 0.015
regulation of photoreceptor cell differentiation GO:0046532 2 0.015
embryonic limb morphogenesis GO:0030326 2 0.015
neuron projection development GO:0031175 180 0.015
segmentation GO:0035282 97 0.015
cell migration GO:0016477 237 0.015
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.015
regulation of response to cytokine stimulus GO:0060759 3 0.015
immune system process GO:0002376 241 0.015
regulation of cell differentiation GO:0045595 142 0.015
erk1 and erk2 cascade GO:0070371 4 0.015
apoptotic process GO:0006915 116 0.015
negative regulation of intracellular transport GO:0032387 3 0.015
regulation of nervous system development GO:0051960 90 0.015
positive regulation of neural precursor cell proliferation GO:2000179 1 0.015
regulation of oocyte development GO:0060281 3 0.015
meiotic cell cycle process GO:1903046 3 0.015
neural crest cell development GO:0014032 62 0.015
regulation of nucleotide catabolic process GO:0030811 2 0.015
regulation of epithelial cell proliferation GO:0050678 3 0.015
negative regulation of kinase activity GO:0033673 4 0.015
regulation of mrna splicing via spliceosome GO:0048024 3 0.015
carboxylic acid metabolic process GO:0019752 22 0.015
septum transversum development GO:0003343 4 0.015
positive regulation of nucleotide catabolic process GO:0030813 1 0.015
establishment of synaptic vesicle localization GO:0097480 1 0.015
regulation of transporter activity GO:0032409 2 0.014
regulation of erk1 and erk2 cascade GO:0070372 4 0.014
stem cell proliferation GO:0072089 4 0.014
regulation of hormone secretion GO:0046883 2 0.014
protein homooligomerization GO:0051260 3 0.014
atp catabolic process GO:0006200 4 0.014
regulation of dendrite development GO:0050773 3 0.014
negative regulation of protein transport GO:0051224 3 0.014
cellular response to nutrient levels GO:0031669 2 0.014
stem cell differentiation GO:0048863 117 0.014
negative regulation of catabolic process GO:0009895 3 0.014
nerve development GO:0021675 45 0.014
phagocytosis GO:0006909 3 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
regulation of nucleoside metabolic process GO:0009118 2 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.014
establishment of localization in cell GO:0051649 77 0.014
Mouse
cellular response to starvation GO:0009267 1 0.014
neural crest cell differentiation GO:0014033 72 0.014
peptide transport GO:0015833 1 0.014
protein complex localization GO:0031503 1 0.014
regulation of neurogenesis GO:0050767 87 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.014
insulin like growth factor receptor signaling pathway GO:0048009 4 0.014
guanosine containing compound catabolic process GO:1901069 2 0.013
negative regulation of signal transduction GO:0009968 94 0.013
cell migration involved in gastrulation GO:0042074 79 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.013
negative regulation of intracellular protein transport GO:0090317 3 0.013
localization of cell GO:0051674 244 0.013
carbohydrate homeostasis GO:0033500 1 0.013
response to monosaccharide GO:0034284 3 0.013
hemopoiesis GO:0030097 183 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
establishment of protein localization to organelle GO:0072594 4 0.013
developmental pigmentation GO:0048066 48 0.013
cellular protein metabolic process GO:0044267 129 0.013
negative regulation of oocyte development GO:0060283 2 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.013
gland development GO:0048732 143 0.013
kidney development GO:0001822 92 0.013
system process GO:0003008 185 0.013
Mouse
epidermis development GO:0008544 48 0.013
macromolecular complex assembly GO:0065003 35 0.013
muscle fiber development GO:0048747 52 0.013
cell morphogenesis involved in differentiation GO:0000904 195 0.013
centrosome organization GO:0051297 1 0.013
regulation of anatomical structure morphogenesis GO:0022603 130 0.013
cardiac muscle tissue development GO:0048738 48 0.013
behavior GO:0007610 74 0.013
regulation of blood circulation GO:1903522 32 0.012
immune system development GO:0002520 191 0.012
lipid catabolic process GO:0016042 4 0.012
secondary metabolic process GO:0019748 3 0.012
b cell activation GO:0042113 2 0.012
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
photoreceptor cell development GO:0042461 40 0.012
small molecule catabolic process GO:0044282 3 0.012
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.012
transcription dna templated GO:0006351 181 0.012
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
connective tissue development GO:0061448 99 0.012
response to corticosteroid GO:0031960 1 0.012
gastrulation GO:0007369 208 0.012
protein secretion GO:0009306 1 0.012
regulation of tube size GO:0035150 2 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.012
membrane invagination GO:0010324 1 0.012
cell projection morphogenesis GO:0048858 244 0.012
cellular nitrogen compound biosynthetic process GO:0044271 218 0.012
negative regulation of reproductive process GO:2000242 3 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.012
organic substance transport GO:0071702 58 0.012
regulation of mrna processing GO:0050684 3 0.012
eye morphogenesis GO:0048592 144 0.011
positive regulation of cell cycle GO:0045787 3 0.011
somatic muscle development GO:0007525 4 0.011
cellular amino acid metabolic process GO:0006520 7 0.011
regulation of cell activation GO:0050865 1 0.011
cranial nerve development GO:0021545 42 0.011
organic acid metabolic process GO:0006082 31 0.011
response to organic substance GO:0010033 153 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
macroautophagy GO:0016236 1 0.011
regulation of myotube differentiation GO:0010830 2 0.011
embryonic appendage morphogenesis GO:0035113 30 0.011
regulation of cytokine production GO:0001817 3 0.011
cell cell signaling GO:0007267 52 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
lipid metabolic process GO:0006629 52 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
protein localization to plasma membrane GO:0072659 1 0.011
peptide metabolic process GO:0006518 1 0.011
positive regulation of wound healing GO:0090303 1 0.011
stem cell division GO:0017145 1 0.011
transport GO:0006810 220 0.011
Mouse
leukocyte proliferation GO:0070661 1 0.011
long chain fatty acid metabolic process GO:0001676 1 0.011
golgi vesicle transport GO:0048193 3 0.011
nuclear export GO:0051168 1 0.011
guanosine containing compound metabolic process GO:1901068 4 0.011
negative regulation of multi organism process GO:0043901 3 0.011
retinoic acid receptor signaling pathway GO:0048384 16 0.011
regulation of gtpase activity GO:0043087 2 0.011
cell fate commitment GO:0045165 99 0.011
response to hexose GO:0009746 3 0.011
regulation of blood vessel size GO:0050880 2 0.011
liver development GO:0001889 96 0.011
viral process GO:0016032 1 0.011
homeostatic process GO:0042592 142 0.011
positive regulation of developmental process GO:0051094 50 0.011
neurological system process GO:0050877 62 0.011
Mouse
inner ear receptor cell differentiation GO:0060113 29 0.011
negative regulation of protein complex assembly GO:0031333 1 0.010
alcohol biosynthetic process GO:0046165 2 0.010
autophagy GO:0006914 4 0.010
negative regulation of programmed cell death GO:0043069 58 0.010
hormone secretion GO:0046879 2 0.010
negative regulation of metabolic process GO:0009892 86 0.010
convergent extension GO:0060026 118 0.010
single organism localization GO:1902578 225 0.010
Mouse
chromosome organization involved in meiosis GO:0070192 1 0.010
pectoral fin development GO:0033339 50 0.010
negative regulation of protein localization to nucleus GO:1900181 2 0.010
medial fin development GO:0033338 16 0.010
intracellular mrna localization GO:0008298 1 0.010
pericardium development GO:0060039 1 0.010
positive regulation of neuron death GO:1901216 1 0.010
cartilage development GO:0051216 96 0.010
rna transport GO:0050658 2 0.010
negative regulation of signaling GO:0023057 96 0.010
mononuclear cell proliferation GO:0032943 1 0.010
protein stabilization GO:0050821 2 0.010
neuromuscular synaptic transmission GO:0007274 2 0.010
purine nucleoside monophosphate catabolic process GO:0009128 4 0.010

rpgrb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.093
immune system disease DOID:2914 0 0.021
disease of cellular proliferation DOID:14566 0 0.019
cancer DOID:162 0 0.019
sensory system disease DOID:0050155 0 0.018
nervous system disease DOID:863 0 0.018
eye and adnexa disease DOID:1492 0 0.018
eye disease DOID:5614 0 0.018
disease of metabolism DOID:0014667 0 0.018
inherited metabolic disorder DOID:655 0 0.018
musculoskeletal system disease DOID:17 0 0.012
muscle tissue disease DOID:66 0 0.011
muscular disease DOID:0080000 0 0.011
myopathy DOID:423 0 0.011
hematopoietic system disease DOID:74 0 0.011
organ system cancer DOID:0050686 0 0.011
retinal disease DOID:5679 0 0.011