Danio rerio

78 known processes

rtn4b

reticulon 4b

(Aliases: rtn6)

rtn4b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
blood vessel morphogenesis GO:0048514 216 0.598
sprouting angiogenesis GO:0002040 53 0.568
blood vessel development GO:0001568 246 0.566
angiogenesis GO:0001525 158 0.387
neuron projection development GO:0031175 180 0.204
eye development GO:0001654 277 0.198
regulation of multicellular organismal development GO:2000026 223 0.185
vasculature development GO:0001944 278 0.184
cell surface receptor signaling pathway GO:0007166 325 0.172
ameboidal type cell migration GO:0001667 143 0.124
heart development GO:0007507 313 0.115
cranial nerve development GO:0021545 42 0.113
embryonic organ morphogenesis GO:0048562 274 0.110
stem cell differentiation GO:0048863 117 0.109
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.104
cellular component movement GO:0006928 335 0.095
embryonic organ development GO:0048568 381 0.095
sensory organ development GO:0007423 393 0.089
stem cell development GO:0048864 82 0.088
locomotion GO:0040011 313 0.085
larval development GO:0002164 2 0.083
determination of left right symmetry GO:0007368 179 0.081
regulation of synapse organization GO:0050807 3 0.080
regulation of reproductive process GO:2000241 4 0.079
forebrain cell migration GO:0021885 1 0.078
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.077
axon development GO:0061564 166 0.077
camera type eye development GO:0043010 222 0.077
lateral line system development GO:0048925 76 0.076
response to chemical GO:0042221 320 0.073
localization of cell GO:0051674 244 0.072
cell projection morphogenesis GO:0048858 244 0.068
neuron projection guidance GO:0097485 86 0.068
sensory system development GO:0048880 76 0.066
sensory perception of chemical stimulus GO:0007606 3 0.064
epithelial tube morphogenesis GO:0060562 148 0.064
regulation of anatomical structure morphogenesis GO:0022603 130 0.063
cell part morphogenesis GO:0032990 246 0.062
branching morphogenesis of a nerve GO:0048755 4 0.059
response to stress GO:0006950 263 0.058
positive regulation of biological process GO:0048518 253 0.058
taxis GO:0042330 109 0.058
muscle cell development GO:0055001 115 0.056
skeletal muscle organ development GO:0060538 78 0.056
heart morphogenesis GO:0003007 156 0.056
developmental growth GO:0048589 166 0.055
mesenchymal cell development GO:0014031 78 0.054
neuron projection morphogenesis GO:0048812 161 0.053
negative regulation of multicellular organismal process GO:0051241 69 0.053
tube morphogenesis GO:0035239 349 0.051
neuron development GO:0048666 262 0.050
cell projection organization GO:0030030 284 0.050
neural crest cell development GO:0014032 62 0.048
muscle structure development GO:0061061 196 0.048
brain development GO:0007420 293 0.047
neuron projection extension GO:1990138 45 0.047
regulation of cellular component organization GO:0051128 86 0.046
regulation of cell differentiation GO:0045595 142 0.045
regulation of synapse assembly GO:0051963 3 0.045
modification dependent protein catabolic process GO:0019941 3 0.044
astrocyte differentiation GO:0048708 1 0.044
regulation of multicellular organismal process GO:0051239 277 0.044
striated muscle cell differentiation GO:0051146 129 0.044
organonitrogen compound metabolic process GO:1901564 74 0.041
regulation of cell motility GO:2000145 46 0.041
cell motility GO:0048870 244 0.040
multicellular organism growth GO:0035264 4 0.040
regulation of cellular amino acid metabolic process GO:0006521 0 0.040
embryo development ending in birth or egg hatching GO:0009792 271 0.038
synaptic growth at neuromuscular junction GO:0051124 2 0.037
central nervous system development GO:0007417 387 0.037
mesenchyme development GO:0060485 127 0.037
organic cyclic compound biosynthetic process GO:1901362 223 0.036
peptidyl serine phosphorylation GO:0018105 1 0.036
striated muscle tissue development GO:0014706 110 0.036
growth GO:0040007 174 0.035
regionalization GO:0003002 274 0.034
neural crest cell differentiation GO:0014033 72 0.034
modification dependent macromolecule catabolic process GO:0043632 3 0.034
heart looping GO:0001947 94 0.034
cognition GO:0050890 1 0.034
head development GO:0060322 303 0.033
regulation of macromolecule metabolic process GO:0060255 317 0.033
positive regulation of catabolic process GO:0009896 4 0.033
axon guidance GO:0007411 86 0.033
cell substrate adhesion GO:0031589 4 0.033
signal transduction GO:0007165 455 0.031
regulation of neurogenesis GO:0050767 87 0.031
regulation of cell migration GO:0030334 40 0.031
regulation of cell development GO:0060284 100 0.031
peripheral nervous system development GO:0007422 55 0.031
cell growth GO:0016049 57 0.030
cell migration GO:0016477 237 0.030
regulation of multicellular organism growth GO:0040014 4 0.030
mechanosensory behavior GO:0007638 2 0.030
regulation of cellular amine metabolic process GO:0033238 0 0.030
regulation of cellular biosynthetic process GO:0031326 245 0.029
neuron differentiation GO:0030182 353 0.029
immune system development GO:0002520 191 0.029
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.029
oxoacid metabolic process GO:0043436 31 0.029
negative regulation of cell migration GO:0030336 17 0.029
transport GO:0006810 220 0.029
negative regulation of cell motility GO:2000146 17 0.029
regulation of neuron projection development GO:0010975 40 0.028
negative regulation of dna metabolic process GO:0051053 4 0.028
ubiquitin dependent protein catabolic process GO:0006511 3 0.028
sodium ion transport GO:0006814 24 0.028
cellular macromolecule metabolic process GO:0044260 391 0.028
small molecule metabolic process GO:0044281 77 0.027
cell morphogenesis involved in differentiation GO:0000904 195 0.027
rna metabolic process GO:0016070 219 0.027
somatic muscle development GO:0007525 4 0.027
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.026
skeletal system development GO:0001501 181 0.026
single organism transport GO:0044765 206 0.026
mesenchymal cell differentiation GO:0048762 87 0.026
peptidyl serine modification GO:0018209 2 0.026
organic acid metabolic process GO:0006082 31 0.026
amine metabolic process GO:0009308 2 0.026
forebrain development GO:0030900 96 0.026
cellular component assembly GO:0022607 170 0.026
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.025
aging GO:0007568 2 0.025
cellular nitrogen compound biosynthetic process GO:0044271 218 0.025
heterocycle biosynthetic process GO:0018130 215 0.025
response to alkaloid GO:0043279 2 0.024
regulation of dna replication GO:0006275 3 0.024
single organism metabolic process GO:0044710 217 0.024
neuron recognition GO:0008038 18 0.024
nitrogen compound metabolic process GO:0006807 319 0.024
neural crest cell migration GO:0001755 42 0.024
aromatic compound biosynthetic process GO:0019438 217 0.024
cellular amine metabolic process GO:0044106 2 0.023
positive regulation of cell adhesion GO:0045785 1 0.023
wnt signaling pathway GO:0016055 80 0.023
energy reserve metabolic process GO:0006112 2 0.023
regulation of neuron differentiation GO:0045664 56 0.023
regulation of cellular metabolic process GO:0031323 320 0.023
negative regulation of protein phosphorylation GO:0001933 4 0.022
regulation of developmental process GO:0050793 247 0.022
cellular carbohydrate metabolic process GO:0044262 4 0.022
morphogenesis of a branching structure GO:0001763 21 0.022
axonal fasciculation GO:0007413 11 0.022
neuromast deposition GO:0048885 9 0.022
organelle assembly GO:0070925 110 0.022
cell matrix adhesion GO:0007160 4 0.022
positive regulation of cellular process GO:0048522 201 0.022
cellular protein catabolic process GO:0044257 4 0.022
synaptic vesicle transport GO:0048489 1 0.021
sensory organ morphogenesis GO:0090596 200 0.021
developmental cell growth GO:0048588 52 0.021
cell morphogenesis GO:0000902 289 0.021
sodium ion transmembrane transport GO:0035725 21 0.021
positive regulation of developmental process GO:0051094 50 0.021
positive regulation of transport GO:0051050 2 0.021
negative regulation of biological process GO:0048519 304 0.021
erythrocyte differentiation GO:0030218 54 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.020
generation of neurons GO:0048699 385 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
cell junction maintenance GO:0034331 2 0.020
muscle tissue development GO:0060537 110 0.020
response to osmotic stress GO:0006970 11 0.019
response to abiotic stimulus GO:0009628 122 0.019
regulation of nervous system development GO:0051960 90 0.019
cellular response to decreased oxygen levels GO:0036294 1 0.019
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.019
regeneration GO:0031099 91 0.019
regulation of locomotion GO:0040012 55 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
biosynthetic process GO:0009058 294 0.019
embryonic cranial skeleton morphogenesis GO:0048701 90 0.019
gene expression GO:0010467 252 0.019
embryonic viscerocranium morphogenesis GO:0048703 52 0.019
meiotic cell cycle process GO:1903046 3 0.019
establishment of localization GO:0051234 244 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
response to external stimulus GO:0009605 264 0.019
neuron neuron synaptic transmission GO:0007270 1 0.018
negative regulation of synapse assembly GO:0051964 2 0.018
neurotransmitter transport GO:0006836 2 0.018
positive regulation of gliogenesis GO:0014015 2 0.018
regulation of protein catabolic process GO:0042176 1 0.018
proteasomal protein catabolic process GO:0010498 2 0.018
adult behavior GO:0030534 2 0.018
cytokinesis GO:0000910 3 0.018
posterior lateral line neuromast deposition GO:0048922 5 0.018
axon extension GO:0048675 45 0.018
response to mechanical stimulus GO:0009612 24 0.018
negative regulation of axon extension GO:0030517 7 0.018
long chain fatty acid metabolic process GO:0001676 1 0.018
nuclear transport GO:0051169 4 0.017
glial cell differentiation GO:0010001 42 0.017
regulation of cellular component movement GO:0051270 55 0.017
cell cycle g1 s phase transition GO:0044843 1 0.017
phagocytosis GO:0006909 3 0.017
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.017
fertilization GO:0009566 3 0.017
action potential GO:0001508 19 0.017
embryonic skeletal system morphogenesis GO:0048704 93 0.017
regulation of carbohydrate metabolic process GO:0006109 4 0.017
skeletal system morphogenesis GO:0048705 102 0.017
myeloid cell differentiation GO:0030099 86 0.017
regulation of intracellular protein transport GO:0033157 3 0.017
striated muscle cell development GO:0055002 108 0.017
negative regulation of dna replication GO:0008156 2 0.017
positive regulation of multicellular organismal process GO:0051240 52 0.016
protein localization to nucleus GO:0034504 3 0.016
synaptic vesicle localization GO:0097479 1 0.016
outflow tract morphogenesis GO:0003151 1 0.016
negative regulation of cellular process GO:0048523 283 0.016
cellular response to hypoxia GO:0071456 1 0.016
regulation of stem cell proliferation GO:0072091 2 0.016
embryonic heart tube morphogenesis GO:0003143 108 0.016
immune system process GO:0002376 241 0.016
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.016
optic nerve development GO:0021554 15 0.016
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.016
atp catabolic process GO:0006200 4 0.016
response to nutrient GO:0007584 3 0.016
regulation of protein ubiquitination GO:0031396 3 0.016
regulation of cell activation GO:0050865 1 0.016
cellular response to chemical stimulus GO:0070887 157 0.016
positive regulation of response to stimulus GO:0048584 80 0.015
mitochondrion organization GO:0007005 4 0.015
cellular component maintenance GO:0043954 3 0.015
multi organism process GO:0051704 134 0.015
regulation of protein transport GO:0051223 3 0.015
cellular response to extracellular stimulus GO:0031668 2 0.015
regulation of response to stimulus GO:0048583 269 0.015
developmental pigmentation GO:0048066 48 0.015
response to organic substance GO:0010033 153 0.015
meiotic nuclear division GO:0007126 4 0.015
eye morphogenesis GO:0048592 144 0.015
central nervous system myelination GO:0022010 2 0.015
regulation of inflammatory response GO:0050727 2 0.015
negative regulation of response to stimulus GO:0048585 104 0.015
single organism localization GO:1902578 225 0.015
auditory receptor cell development GO:0060117 8 0.015
cation transmembrane transport GO:0098655 65 0.015
pronephros development GO:0048793 69 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.015
axon ensheathment in central nervous system GO:0032291 2 0.015
regulation of rna metabolic process GO:0051252 224 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
specification of symmetry GO:0009799 204 0.014
segmentation GO:0035282 97 0.014
chordate embryonic development GO:0043009 271 0.014
adherens junction organization GO:0034332 4 0.014
transmission of nerve impulse GO:0019226 19 0.014
regulation of cytokine production GO:0001817 3 0.014
embryonic hemopoiesis GO:0035162 53 0.014
regulation of circadian rhythm GO:0042752 4 0.014
cellular component morphogenesis GO:0032989 336 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
regulation of cell morphogenesis GO:0022604 42 0.014
enzyme linked receptor protein signaling pathway GO:0007167 106 0.014
regulation of metabolic process GO:0019222 359 0.014
purine nucleoside monophosphate catabolic process GO:0009128 4 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
nerve development GO:0021675 45 0.013
establishment of protein localization to organelle GO:0072594 4 0.013
gtp metabolic process GO:0046039 4 0.013
cell migration involved in gastrulation GO:0042074 79 0.013
posterior lateral line system development GO:0048915 46 0.013
axonogenesis GO:0007409 152 0.013
anatomical structure arrangement GO:0048532 2 0.013
primary neural tube formation GO:0014020 1 0.013
positive regulation of cellular catabolic process GO:0031331 3 0.013
negative regulation of cellular component movement GO:0051271 18 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
positive regulation of reproductive process GO:2000243 2 0.013
organic substance biosynthetic process GO:1901576 289 0.013
cellular response to organic substance GO:0071310 105 0.013
camera type eye morphogenesis GO:0048593 108 0.013
connective tissue development GO:0061448 99 0.013
gtp catabolic process GO:0006184 2 0.013
epithelium migration GO:0090132 25 0.013
protein targeting to nucleus GO:0044744 3 0.013
regulation of nucleocytoplasmic transport GO:0046822 2 0.013
positive regulation of cell activation GO:0050867 1 0.012
morphogenesis of an epithelium GO:0002009 333 0.012
regulation of cell size GO:0008361 29 0.012
embryonic heart tube development GO:0035050 133 0.012
neuroblast proliferation GO:0007405 2 0.012
regulation of cellular component size GO:0032535 30 0.012
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.012
positive regulation of glial cell differentiation GO:0045687 1 0.012
protein import into nucleus GO:0006606 3 0.012
nuclear import GO:0051170 3 0.012
lens development in camera type eye GO:0002088 22 0.012
positive regulation of signal transduction GO:0009967 56 0.012
fatty acid biosynthetic process GO:0006633 4 0.012
regulation of signaling GO:0023051 235 0.012
cellular biosynthetic process GO:0044249 286 0.012
protein import GO:0017038 3 0.012
hormone secretion GO:0046879 2 0.012
cellular component biogenesis GO:0044085 178 0.012
muscle cell differentiation GO:0042692 139 0.012
determination of heart left right asymmetry GO:0061371 117 0.012
regulation of cellular ketone metabolic process GO:0010565 7 0.012
cytokinetic process GO:0032506 2 0.012
muscle organ development GO:0007517 101 0.012
cell death GO:0008219 121 0.011
neuromuscular process controlling balance GO:0050885 3 0.011
regulation of meiotic cell cycle GO:0051445 1 0.011
somite development GO:0061053 96 0.011
negative regulation of reproductive process GO:2000242 3 0.011
endomembrane system organization GO:0010256 13 0.011
negative regulation of kinase activity GO:0033673 4 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
nucleoside monophosphate catabolic process GO:0009125 4 0.011
cellular nitrogen compound metabolic process GO:0034641 290 0.011
somitogenesis GO:0001756 87 0.011
golgi vesicle transport GO:0048193 3 0.011
cellular protein metabolic process GO:0044267 129 0.011
developmental growth involved in morphogenesis GO:0060560 86 0.011
g protein coupled receptor signaling pathway GO:0007186 74 0.011
sensory perception of pain GO:0019233 1 0.011
embryonic skeletal system development GO:0048706 97 0.011
cellular response to oxygen levels GO:0071453 1 0.011
dendrite guidance GO:0070983 0 0.011
cardiocyte differentiation GO:0035051 44 0.011
pigment cell differentiation GO:0050931 38 0.011
heterocycle metabolic process GO:0046483 290 0.011
negative regulation of cell communication GO:0010648 96 0.011
positive regulation of multi organism process GO:0043902 3 0.011
positive regulation of apoptotic signaling pathway GO:2001235 1 0.011
epithelial cell differentiation GO:0030855 116 0.011
positive regulation of cell projection organization GO:0031346 9 0.011
nucleic acid metabolic process GO:0090304 244 0.011
stem cell maintenance GO:0019827 4 0.011
regulation of cell projection organization GO:0031344 44 0.011
ventral spinal cord development GO:0021517 35 0.011
regulation of nitrogen compound metabolic process GO:0051171 251 0.010
long chain fatty acid biosynthetic process GO:0042759 1 0.010
glucose import GO:0046323 2 0.010
cartilage development GO:0051216 96 0.010
programmed cell death GO:0012501 119 0.010
regulation of wnt signaling pathway GO:0030111 53 0.010
axonal defasciculation GO:0007414 2 0.010
embryonic appendage morphogenesis GO:0035113 30 0.010
wound healing GO:0042060 90 0.010
tube closure GO:0060606 1 0.010
negative regulation of cytokine production GO:0001818 1 0.010
regulation of glial cell differentiation GO:0045685 4 0.010
retina morphogenesis in camera type eye GO:0060042 79 0.010
medial fin development GO:0033338 16 0.010
water homeostasis GO:0030104 4 0.010
cyclic purine nucleotide metabolic process GO:0052652 18 0.010

rtn4b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
cardiovascular system disease DOID:1287 0 0.020
disease of metabolism DOID:0014667 0 0.013
musculoskeletal system disease DOID:17 0 0.013
brain disease DOID:936 0 0.012
central nervous system disease DOID:331 0 0.012