Danio rerio

0 known processes

runx2a

runt-related transcription factor 2a

runx2a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule metabolic process GO:0044260 391 0.951
Human Zebrafish Mouse Fly
nitrogen compound metabolic process GO:0006807 319 0.949
Human Zebrafish Mouse Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.910
Human Zebrafish Mouse Fly
embryonic organ morphogenesis GO:0048562 274 0.873
Zebrafish Mouse
positive regulation of cellular process GO:0048522 201 0.858
Human Zebrafish Mouse Fly
central nervous system development GO:0007417 387 0.857
regulation of rna metabolic process GO:0051252 224 0.794
Human Zebrafish Mouse Fly
positive regulation of macromolecule metabolic process GO:0010604 93 0.791
Human Zebrafish Mouse Fly
odontogenesis of dentin containing tooth GO:0042475 1 0.771
Mouse
regulation of primary metabolic process GO:0080090 311 0.760
Human Zebrafish Mouse Fly
regulation of metabolic process GO:0019222 359 0.751
Human Zebrafish Mouse Fly
heterocycle biosynthetic process GO:0018130 215 0.747
Human Zebrafish Mouse Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.743
Human Zebrafish Mouse Fly
chordate embryonic development GO:0043009 271 0.724
Zebrafish Mouse
heterocycle metabolic process GO:0046483 290 0.702
Human Zebrafish Mouse Fly
immune system process GO:0002376 241 0.681
Zebrafish Mouse Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.676
Human Zebrafish Mouse Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.664
Human Zebrafish Mouse Fly
regulation of multicellular organismal process GO:0051239 277 0.650
Mouse Worm Fly
embryonic skeletal system development GO:0048706 97 0.646
Zebrafish Mouse
signal transduction GO:0007165 455 0.645
Mouse
positive regulation of biological process GO:0048518 253 0.645
Human Zebrafish Mouse Worm Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.639
Human Zebrafish Mouse Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.630
Human Zebrafish Mouse Fly
aromatic compound biosynthetic process GO:0019438 217 0.624
Human Zebrafish Mouse Fly
embryonic skeletal system morphogenesis GO:0048704 93 0.615
Zebrafish Mouse
tube morphogenesis GO:0035239 349 0.602
Fly
regulation of gene expression GO:0010468 265 0.579
Human Zebrafish Mouse Fly
regulation of rna biosynthetic process GO:2001141 213 0.579
Human Zebrafish Mouse Fly
positive regulation of rna metabolic process GO:0051254 59 0.573
Human Zebrafish Mouse Fly
response to external stimulus GO:0009605 264 0.562
Fly
t cell differentiation GO:0030217 6 0.555
Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.549
Human Zebrafish Mouse Fly
transport GO:0006810 220 0.539
positive regulation of metabolic process GO:0009893 108 0.535
Human Zebrafish Mouse Fly
biosynthetic process GO:0009058 294 0.532
Human Zebrafish Mouse Fly
t cell activation GO:0042110 6 0.531
Mouse
macromolecule biosynthetic process GO:0009059 227 0.528
Human Zebrafish Mouse Fly
regulation of transcription dna templated GO:0006355 213 0.525
Human Zebrafish Mouse Fly
organic cyclic compound metabolic process GO:1901360 301 0.516
Human Zebrafish Mouse Fly
nucleic acid templated transcription GO:0097659 181 0.511
Human Zebrafish Mouse Fly
sensory organ development GO:0007423 393 0.508
Fly
growth GO:0040007 174 0.506
Worm
cellular aromatic compound metabolic process GO:0006725 295 0.499
Human Zebrafish Mouse Fly
glial cell migration GO:0008347 3 0.488
response to other organism GO:0051707 97 0.488
skeletal system development GO:0001501 181 0.483
Zebrafish Mouse
digestive system development GO:0055123 289 0.481
Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.472
Human Zebrafish Mouse Fly
inner ear development GO:0048839 126 0.470
regulation of nucleic acid templated transcription GO:1903506 213 0.467
Human Zebrafish Mouse Fly
hemopoiesis GO:0030097 183 0.466
Zebrafish Mouse Fly
ameboidal type cell migration GO:0001667 143 0.465
regulation of biosynthetic process GO:0009889 250 0.451
Human Zebrafish Mouse Fly
sensory organ morphogenesis GO:0090596 200 0.437
Fly
multi organism process GO:0051704 134 0.431
embryonic cranial skeleton morphogenesis GO:0048701 90 0.428
Zebrafish Mouse
embryonic organ development GO:0048568 381 0.422
Zebrafish Mouse Fly
phosphorus metabolic process GO:0006793 109 0.417
ossification GO:0001503 23 0.408
Human Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.404
Human Zebrafish Mouse Fly
negative regulation of biological process GO:0048519 304 0.393
Human Mouse Fly
regulation of cellular metabolic process GO:0031323 320 0.383
Human Zebrafish Mouse Fly
mechanoreceptor differentiation GO:0042490 37 0.365
chondrocyte development GO:0002063 4 0.361
Mouse
cell morphogenesis GO:0000902 289 0.361
Fly
transcription dna templated GO:0006351 181 0.357
Human Zebrafish Mouse Fly
endocrine system development GO:0035270 65 0.354
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.354
Human Zebrafish Mouse Fly
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.353
transcription from rna polymerase ii promoter GO:0006366 80 0.349
Mouse Fly
rna biosynthetic process GO:0032774 181 0.344
Human Zebrafish Mouse Fly
appendage development GO:0048736 80 0.344
Mouse
hematopoietic or lymphoid organ development GO:0048534 191 0.342
Zebrafish Mouse Fly
regulation of developmental process GO:0050793 247 0.326
Mouse Worm Fly
protein localization to nucleus GO:0034504 3 0.326
nucleic acid metabolic process GO:0090304 244 0.325
Human Zebrafish Mouse Fly
neuron projection morphogenesis GO:0048812 161 0.322
Fly
cellular component biogenesis GO:0044085 178 0.320
response to stress GO:0006950 263 0.313
Fly
positive regulation of cellular biosynthetic process GO:0031328 68 0.312
Human Zebrafish Mouse Fly
digestive tract development GO:0048565 265 0.311
Fly
leukocyte differentiation GO:0002521 25 0.309
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.305
Human Zebrafish Mouse Fly
response to external biotic stimulus GO:0043207 97 0.303
ear development GO:0043583 127 0.298
cell surface receptor signaling pathway GO:0007166 325 0.295
Mouse
immune system development GO:0002520 191 0.294
Zebrafish Mouse Fly
generation of neurons GO:0048699 385 0.294
Fly
cellular response to chemical stimulus GO:0070887 157 0.294
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.293
Human Zebrafish Mouse Fly
organic substance biosynthetic process GO:1901576 289 0.290
Human Zebrafish Mouse Fly
myotube cell development GO:0014904 35 0.287
protein modification process GO:0036211 100 0.287
neuromuscular synaptic transmission GO:0007274 2 0.286
aging GO:0007568 2 0.286
leukocyte proliferation GO:0070661 1 0.283
appendage morphogenesis GO:0035107 56 0.281
Mouse
positive regulation of transcription dna templated GO:0045893 57 0.281
Human Zebrafish Mouse Fly
locomotion GO:0040011 313 0.280
Fly
positive regulation of developmental process GO:0051094 50 0.277
Mouse Worm Fly
regulation of macromolecule metabolic process GO:0060255 317 0.277
Human Zebrafish Mouse Fly
stem cell differentiation GO:0048863 117 0.271
Mouse
rna metabolic process GO:0016070 219 0.261
Human Zebrafish Mouse Fly
kidney development GO:0001822 92 0.260
neuron differentiation GO:0030182 353 0.260
Fly
enzyme linked receptor protein signaling pathway GO:0007167 106 0.253
Mouse
cell part morphogenesis GO:0032990 246 0.249
Fly
eye morphogenesis GO:0048592 144 0.249
Fly
defense response GO:0006952 47 0.247
neuron development GO:0048666 262 0.246
Fly
positive regulation of cell differentiation GO:0045597 30 0.245
Mouse Fly
response to wounding GO:0009611 116 0.244
Fly
regulation of nervous system development GO:0051960 90 0.237
regulation of cell differentiation GO:0045595 142 0.236
Mouse Fly
gastrulation GO:0007369 208 0.234
Fly
negative regulation of cellular process GO:0048523 283 0.232
Human Mouse Fly
urogenital system development GO:0001655 97 0.230
regulation of signal transduction GO:0009966 225 0.228
Mouse
muscle cell differentiation GO:0042692 139 0.227
muscle structure development GO:0061061 196 0.223
muscle cell development GO:0055001 115 0.222
developmental growth GO:0048589 166 0.217
Worm
eye development GO:0001654 277 0.216
Fly
cell fate specification GO:0001708 68 0.212
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.212
Human Mouse Fly
positive regulation of rna biosynthetic process GO:1902680 57 0.211
Human Zebrafish Mouse Fly
regulation of multicellular organismal development GO:2000026 223 0.208
Mouse Fly
axon guidance GO:0007411 86 0.205
Fly
positive regulation of transport GO:0051050 2 0.203
cellular component movement GO:0006928 335 0.196
Fly
nephron epithelium morphogenesis GO:0072088 1 0.192
cellular response to organic substance GO:0071310 105 0.190
Mouse
regulation of cell cycle GO:0051726 52 0.186
muscle tissue development GO:0060537 110 0.185
establishment of localization GO:0051234 244 0.184
peptide transport GO:0015833 1 0.180
homeostatic process GO:0042592 142 0.180
gene expression GO:0010467 252 0.180
Human Zebrafish Mouse Fly
protein targeting to nucleus GO:0044744 3 0.179
regulation of endodermal cell fate specification GO:0042663 15 0.178
skeletal muscle fiber development GO:0048741 35 0.177
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.176
Mouse Fly
single organism localization GO:1902578 225 0.174
hepaticobiliary system development GO:0061008 98 0.173
nucleobase containing compound metabolic process GO:0006139 274 0.172
Human Zebrafish Mouse Fly
response to endogenous stimulus GO:0009719 83 0.171
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.170
Mouse Fly
amide transport GO:0042886 12 0.169
cellular component assembly GO:0022607 170 0.168
regulation of cellular component organization GO:0051128 86 0.168
dorsal ventral pattern formation GO:0009953 125 0.165
Zebrafish
regulation of anatomical structure morphogenesis GO:0022603 130 0.165
Mouse Fly
regulation of stem cell differentiation GO:2000736 4 0.163
positive regulation of biosynthetic process GO:0009891 68 0.161
Human Zebrafish Mouse Fly
regulation of immune system process GO:0002682 34 0.161
organelle localization GO:0051640 49 0.161
small molecule metabolic process GO:0044281 77 0.159
heart development GO:0007507 313 0.155
regulation of neurogenesis GO:0050767 87 0.155
regulation of localization GO:0032879 104 0.154
brain development GO:0007420 293 0.153
skeletal system morphogenesis GO:0048705 102 0.151
Zebrafish Mouse
bmp signaling pathway GO:0030509 52 0.150
Mouse
negative regulation of response to stimulus GO:0048585 104 0.149
Mouse
lymphocyte differentiation GO:0030098 9 0.149
Mouse
larval development GO:0002164 2 0.147
cellular response to growth factor stimulus GO:0071363 39 0.147
Mouse
type b pancreatic cell development GO:0003323 4 0.146
cell projection assembly GO:0030031 64 0.145
inner ear receptor cell differentiation GO:0060113 29 0.145
modification dependent protein catabolic process GO:0019941 3 0.145
positive regulation of gene expression GO:0010628 71 0.143
Human Zebrafish Mouse Fly
mononuclear cell proliferation GO:0032943 1 0.141
establishment of localization in cell GO:0051649 77 0.140
cell migration GO:0016477 237 0.139
renal system development GO:0072001 94 0.139
regulation of cartilage development GO:0061035 7 0.135
Mouse
positive regulation of cell communication GO:0010647 56 0.134
regulation of signaling GO:0023051 235 0.133
Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.131
Human Zebrafish Mouse Fly
embryonic viscerocranium morphogenesis GO:0048703 52 0.131
Zebrafish
multicellular organismal homeostasis GO:0048871 29 0.131
microtubule cytoskeleton organization GO:0000226 33 0.130
otic vesicle development GO:0071599 42 0.127
response to chemical GO:0042221 320 0.127
Mouse Fly
mesoderm development GO:0007498 88 0.126
protein complex subunit organization GO:0071822 46 0.125
cellular protein catabolic process GO:0044257 4 0.124
lymphocyte activation GO:0046649 10 0.124
Mouse
cell fate commitment GO:0045165 99 0.123
Mouse
tissue regeneration GO:0042246 74 0.123
cartilage condensation GO:0001502 3 0.122
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.122
Human Zebrafish Mouse Fly
regulation of cell communication GO:0010646 232 0.120
Mouse
neuron projection guidance GO:0097485 86 0.118
Fly
response to biotic stimulus GO:0009607 97 0.116
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.113
Human Mouse Fly
regulation of establishment of protein localization GO:0070201 4 0.111
response to alkaloid GO:0043279 2 0.111
response to bacterium GO:0009617 58 0.111
protein secretion GO:0009306 1 0.110
wound healing GO:0042060 90 0.110
Fly
cellular component morphogenesis GO:0032989 336 0.110
Fly
peripheral nervous system neuron differentiation GO:0048934 28 0.107
negative regulation of transcription dna templated GO:0045892 45 0.107
Human Mouse Fly
auditory receptor cell fate commitment GO:0009912 4 0.106
regulation of cell activation GO:0050865 1 0.106
cellular protein modification process GO:0006464 100 0.106
regulation of multicellular organism growth GO:0040014 4 0.104
Worm
cell projection organization GO:0030030 284 0.104
Fly
cellular localization GO:0051641 97 0.103
nephron morphogenesis GO:0072028 2 0.103
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.103
specification of symmetry GO:0009799 204 0.102
gliogenesis GO:0042063 45 0.101
negative regulation of gene expression GO:0010629 65 0.099
Human Mouse Fly
single organism nuclear import GO:1902593 3 0.098
lipid catabolic process GO:0016042 4 0.098
regulation of protein metabolic process GO:0051246 56 0.098
lymphocyte proliferation GO:0046651 1 0.097
renal system vasculature development GO:0061437 2 0.097
developmental maturation GO:0021700 34 0.097
Mouse
response to organic cyclic compound GO:0014070 51 0.097
cellular biosynthetic process GO:0044249 286 0.096
Human Zebrafish Mouse Fly
positive regulation of multicellular organismal process GO:0051240 52 0.095
Mouse Worm Fly
otic vesicle morphogenesis GO:0071600 34 0.093
modification dependent macromolecule catabolic process GO:0043632 3 0.093
nephron tubule morphogenesis GO:0072078 1 0.090
collagen metabolic process GO:0032963 2 0.090
positive regulation of immune system process GO:0002684 17 0.089
protein localization GO:0008104 40 0.089
skeletal muscle tissue development GO:0007519 67 0.089
er nucleus signaling pathway GO:0006984 2 0.088
cell morphogenesis involved in differentiation GO:0000904 195 0.088
Fly
stem cell proliferation GO:0072089 4 0.088
caudal fin morphogenesis GO:0035143 7 0.087
maintenance of location GO:0051235 4 0.087
camera type eye development GO:0043010 222 0.086
regulation of transport GO:0051049 45 0.083
fin development GO:0033333 77 0.083
mesenchyme development GO:0060485 127 0.083
head development GO:0060322 303 0.082
convergent extension GO:0060026 118 0.082
regulation of response to stimulus GO:0048583 269 0.082
Mouse
myotube differentiation GO:0014902 45 0.081
regulation of cell development GO:0060284 100 0.081
Fly
protein import into nucleus GO:0006606 3 0.081
positive regulation of cell proliferation GO:0008284 15 0.081
Mouse
defense response to other organism GO:0098542 33 0.081
forebrain development GO:0030900 96 0.080
positive regulation of cell cycle GO:0045787 3 0.080
fin regeneration GO:0031101 51 0.080
organelle organization GO:0006996 227 0.080
regulation of cell morphogenesis GO:0022604 42 0.079
cellular response to external stimulus GO:0071496 2 0.079
negative regulation of biosynthetic process GO:0009890 55 0.079
Human Mouse Fly
reproduction GO:0000003 40 0.079
Worm
nephron development GO:0072006 31 0.078
gland development GO:0048732 143 0.078
morphogenesis of a branching structure GO:0001763 21 0.078
muscle fiber development GO:0048747 52 0.077
neuron projection development GO:0031175 180 0.077
Fly
regulation of ossification GO:0030278 5 0.077
Mouse
regulation of epithelial to mesenchymal transition GO:0010717 3 0.075
positive regulation of muscle organ development GO:0048636 1 0.075
medial fin development GO:0033338 16 0.075
ubiquitin dependent protein catabolic process GO:0006511 3 0.074
osteoblast differentiation GO:0001649 5 0.074
Human Mouse
cell motility GO:0048870 244 0.073
otic vesicle formation GO:0030916 27 0.072
epithelial cell development GO:0002064 42 0.072
regulation of cytokine production GO:0001817 3 0.072
establishment of protein localization to organelle GO:0072594 4 0.071
taxis GO:0042330 109 0.071
Fly
hair cell differentiation GO:0035315 32 0.071
wnt signaling pathway GO:0016055 80 0.070
convergent extension involved in organogenesis GO:0060029 10 0.070
intracellular signal transduction GO:0035556 85 0.070
response to abiotic stimulus GO:0009628 122 0.069
single organism cellular localization GO:1902580 46 0.069
multicellular organismal reproductive process GO:0048609 35 0.069
skeletal muscle organ development GO:0060538 78 0.068
cell proliferation GO:0008283 80 0.068
Mouse
positive regulation of apoptotic process GO:0043065 29 0.067
embryonic skeletal joint development GO:0072498 3 0.067
camera type eye morphogenesis GO:0048593 108 0.067
signal transduction in absence of ligand GO:0038034 1 0.066
phosphorylation GO:0016310 69 0.066
glucose homeostasis GO:0042593 1 0.066
bone morphogenesis GO:0060349 11 0.065
Mouse
connective tissue development GO:0061448 99 0.065
Zebrafish Mouse
regulation of protein transport GO:0051223 3 0.064
vasculature development GO:0001944 278 0.064
nuclear transport GO:0051169 4 0.063
cellular protein localization GO:0034613 20 0.063
negative regulation of macromolecule metabolic process GO:0010605 76 0.063
Human Mouse Fly
positive regulation of nucleic acid templated transcription GO:1903508 57 0.063
Human Zebrafish Mouse Fly
renal tubule morphogenesis GO:0061333 1 0.062
single organism metabolic process GO:0044710 217 0.062
localization of cell GO:0051674 244 0.061
regulation of hormone secretion GO:0046883 2 0.061
foregut morphogenesis GO:0007440 4 0.061
positive regulation of signaling GO:0023056 56 0.061
regulation of biological quality GO:0065008 263 0.060
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.060
Fly
cellular response to endogenous stimulus GO:0071495 68 0.060
Mouse
positive regulation of signal transduction GO:0009967 56 0.060
regulation of protein catabolic process GO:0042176 1 0.060
bone development GO:0060348 14 0.060
Mouse
regulation of mitotic cell cycle GO:0007346 25 0.059
response to carbohydrate GO:0009743 3 0.059
cellular response to retinoic acid GO:0071300 1 0.058
morphogenesis of an epithelium GO:0002009 333 0.057
epidermal cell differentiation GO:0009913 36 0.057
single organism behavior GO:0044708 24 0.056
regulation of cell motility GO:2000145 46 0.056
determination of left right symmetry GO:0007368 179 0.055
positive regulation of cell activation GO:0050867 1 0.055
multicellular organism growth GO:0035264 4 0.055
Worm
embryonic heart tube development GO:0035050 133 0.055
regulation of cytoplasmic transport GO:1903649 4 0.054
endodermal cell fate determination GO:0007493 2 0.053
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.053
Fly
cranial suture morphogenesis GO:0060363 1 0.053
extracellular structure organization GO:0043062 27 0.052
secondary metabolic process GO:0019748 3 0.052
system process GO:0003008 185 0.052
negative regulation of metabolic process GO:0009892 86 0.052
Human Mouse Fly
single organism transport GO:0044765 206 0.051
regulation of cellular protein metabolic process GO:0032268 52 0.051
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.051
regulation of reproductive process GO:2000241 4 0.050
regulation of nucleocytoplasmic transport GO:0046822 2 0.050
glomerulus vasculature development GO:0072012 2 0.050
intracellular transport GO:0046907 32 0.050
nitrogen compound transport GO:0071705 23 0.050
immune effector process GO:0002252 23 0.050
negative regulation of rna biosynthetic process GO:1902679 45 0.049
Human Mouse Fly
endochondral bone morphogenesis GO:0060350 8 0.049
Mouse
positive regulation of cell division GO:0051781 2 0.049
heart looping GO:0001947 94 0.048
immune response GO:0006955 28 0.048
negative regulation of developmental process GO:0051093 65 0.047
embryonic camera type eye development GO:0031076 29 0.047
protein phosphorylation GO:0006468 47 0.047
protein heterooligomerization GO:0051291 1 0.047
smoothened signaling pathway GO:0007224 30 0.046
Mouse
fin morphogenesis GO:0033334 53 0.046
ion homeostasis GO:0050801 41 0.046
positive regulation of epithelial cell differentiation GO:0030858 2 0.046
glycoprotein metabolic process GO:0009100 23 0.045
protein import GO:0017038 3 0.045
regulation of molecular function GO:0065009 70 0.044
embryonic camera type eye morphogenesis GO:0048596 19 0.044
pancreas development GO:0031016 84 0.044
cell cycle GO:0007049 93 0.044
liver development GO:0001889 96 0.043
regulation of cellular response to growth factor stimulus GO:0090287 35 0.043
Mouse
embryonic limb morphogenesis GO:0030326 2 0.043
Mouse
endothelial cell differentiation GO:0045446 20 0.043
negative regulation of cellular metabolic process GO:0031324 77 0.042
Human Mouse Fly
embryonic eye morphogenesis GO:0048048 30 0.042
positive regulation of molecular function GO:0044093 33 0.042
nucleocytoplasmic transport GO:0006913 4 0.042
hindbrain development GO:0030902 91 0.042
myeloid cell differentiation GO:0030099 86 0.042
response to drug GO:0042493 3 0.042
glomerulus development GO:0032835 27 0.041
determination of bilateral symmetry GO:0009855 204 0.041
positive regulation of catabolic process GO:0009896 4 0.041
cell death GO:0008219 121 0.041
Fly
leukocyte activation GO:0045321 12 0.041
Mouse
negative regulation of muscle cell differentiation GO:0051148 1 0.041
negative regulation of cell differentiation GO:0045596 46 0.040
regulation of programmed cell death GO:0043067 101 0.040
Fly
single organism organelle organization GO:1902589 199 0.040
regulation of protein localization to nucleus GO:1900180 2 0.039
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.039
Human Mouse Fly
specification of organ identity GO:0010092 2 0.039
regulation of cell migration GO:0030334 40 0.039
retina development in camera type eye GO:0060041 146 0.039
response to corticosteroid GO:0031960 1 0.039
embryonic heart tube morphogenesis GO:0003143 108 0.039
regulation of cell division GO:0051302 12 0.039
multicellular organism reproduction GO:0032504 35 0.038
catabolic process GO:0009056 32 0.038
regulation of gastrulation GO:0010470 24 0.038
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.038
epithelial tube morphogenesis GO:0060562 148 0.037
cell maturation GO:0048469 23 0.037
Mouse
striated muscle tissue development GO:0014706 110 0.037
peripheral nervous system neuron development GO:0048935 22 0.037
regulation of oligodendrocyte differentiation GO:0048713 1 0.036
medial fin morphogenesis GO:0035141 14 0.036
regulation of protein import into nucleus GO:0042306 2 0.036
embryonic neurocranium morphogenesis GO:0048702 15 0.036
negative regulation of rna metabolic process GO:0051253 48 0.036
Human Mouse Fly
adenohypophysis development GO:0021984 15 0.035
regulation of metal ion transport GO:0010959 4 0.035
ectodermal placode development GO:0071696 37 0.035
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.034
Mouse
determination of heart left right asymmetry GO:0061371 117 0.034
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.034
calcium ion transport GO:0006816 18 0.034
positive regulation of programmed cell death GO:0043068 29 0.034
Fly
digestive tract morphogenesis GO:0048546 231 0.034
Fly
regulation of myotube differentiation GO:0010830 2 0.033
positive regulation of inflammatory response GO:0050729 1 0.033
negative regulation of cellular biosynthetic process GO:0031327 55 0.033
Human Mouse Fly
inner ear morphogenesis GO:0042472 63 0.033
kupffer s vesicle development GO:0070121 50 0.033
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.033
Human Mouse Fly
swim bladder inflation GO:0048798 5 0.033
mitotic cell cycle process GO:1903047 48 0.033
positive regulation of cellular component biogenesis GO:0044089 3 0.033
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.033
lipid biosynthetic process GO:0008610 22 0.032
striated muscle cell development GO:0055002 108 0.032
regulation of apoptotic process GO:0042981 98 0.032
Fly
proteolysis GO:0006508 38 0.032
branching morphogenesis of an epithelial tube GO:0048754 15 0.031
protein acetylation GO:0006473 2 0.031
defense response to bacterium GO:0042742 22 0.031
locomotor rhythm GO:0045475 3 0.031
organic acid metabolic process GO:0006082 31 0.031
pronephros development GO:0048793 69 0.030
positive regulation of stem cell proliferation GO:2000648 1 0.030
regulation of inflammatory response GO:0050727 2 0.030
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.030
bmp signaling pathway involved in heart jogging GO:0003303 14 0.030
regulation of calcium ion transport GO:0051924 2 0.030
cellular protein metabolic process GO:0044267 129 0.030
response to glucocorticoid GO:0051384 1 0.030
response to nutrient GO:0007584 3 0.030
embryonic hemopoiesis GO:0035162 53 0.030
Fly
developmental programmed cell death GO:0010623 4 0.030
Fly
response to monosaccharide GO:0034284 3 0.030
regulation of neuron differentiation GO:0045664 56 0.030
formation of primary germ layer GO:0001704 62 0.029
response to mechanical stimulus GO:0009612 24 0.029
hormone biosynthetic process GO:0042446 3 0.029
determination of ventral identity GO:0048264 21 0.029
ear morphogenesis GO:0042471 64 0.029
response to immobilization stress GO:0035902 1 0.029
cell cell signaling GO:0007267 52 0.029
negative regulation of feeding behavior GO:2000252 2 0.029
stem cell division GO:0017145 1 0.028
positive regulation of cell death GO:0010942 29 0.028
Fly
response to steroid hormone GO:0048545 35 0.028
positive regulation of cellular catabolic process GO:0031331 3 0.028
heart morphogenesis GO:0003007 156 0.028
cartilage development GO:0051216 96 0.028
Zebrafish Mouse
multicellular organismal macromolecule metabolic process GO:0044259 2 0.028
oxoacid metabolic process GO:0043436 31 0.028
positive regulation of secretion by cell GO:1903532 1 0.027
epithelial cell morphogenesis GO:0003382 2 0.027
nuclear import GO:0051170 3 0.027
striated muscle cell differentiation GO:0051146 129 0.027
stem cell development GO:0048864 82 0.027
regeneration GO:0031099 91 0.027
negative regulation of nucleic acid templated transcription GO:1903507 45 0.027
Human Mouse Fly
ectodermal placode morphogenesis GO:0071697 32 0.027
protein complex biogenesis GO:0070271 30 0.027
regulation of organelle organization GO:0033043 29 0.027
calcium ion homeostasis GO:0055074 19 0.026
macromolecule localization GO:0033036 54 0.026
fibroblast growth factor receptor signaling pathway GO:0008543 22 0.026
Mouse
i kappab kinase nf kappab signaling GO:0007249 4 0.026
vestibular receptor cell development GO:0060118 3 0.026
cellular ketone metabolic process GO:0042180 11 0.026
activation of mapk activity GO:0000187 3 0.026
alcohol biosynthetic process GO:0046165 2 0.026
response to light stimulus GO:0009416 46 0.026
single organism intracellular transport GO:1902582 25 0.026
pathway restricted smad protein phosphorylation GO:0060389 1 0.026
embryonic digestive tract development GO:0048566 4 0.026
embryonic pattern specification GO:0009880 44 0.026
chemotaxis GO:0006935 104 0.025
Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.025
Mouse
reproductive process GO:0022414 40 0.025
Worm Fly
intracellular receptor signaling pathway GO:0030522 30 0.025
cell activation GO:0001775 16 0.025
Mouse
cellular response to lipid GO:0071396 39 0.025
striated muscle cell proliferation GO:0014855 7 0.025
sequestering of calcium ion GO:0051208 3 0.025
hard palate development GO:0060022 4 0.025
phosphate containing compound metabolic process GO:0006796 108 0.025
regulation of cell cycle process GO:0010564 20 0.024

runx2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.657
Human
osteochondrodysplasia DOID:2256 0 0.287
Human
bone development disease DOID:0080006 0 0.287
Human
bone disease DOID:0080001 0 0.287
Human
connective tissue disease DOID:65 0 0.287
Human
musculoskeletal system disease DOID:17 0 0.287
Human
nervous system disease DOID:863 0 0.109