Danio rerio

83 known processes

runx2b

runt-related transcription factor 2b

runx2b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of rna metabolic process GO:0051252 224 0.995
regulation of biosynthetic process GO:0009889 250 0.991
cellular macromolecule metabolic process GO:0044260 391 0.985
organic substance biosynthetic process GO:1901576 289 0.983
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.977
regulation of metabolic process GO:0019222 359 0.974
digestive system development GO:0055123 289 0.970
Fly
cellular biosynthetic process GO:0044249 286 0.964
organic cyclic compound biosynthetic process GO:1901362 223 0.962
regulation of primary metabolic process GO:0080090 311 0.961
sensory organ morphogenesis GO:0090596 200 0.960
Fly
macromolecule biosynthetic process GO:0009059 227 0.949
regulation of gene expression GO:0010468 265 0.947
regulation of cellular metabolic process GO:0031323 320 0.945
embryonic organ development GO:0048568 381 0.943
Zebrafish Mouse Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.929
rna metabolic process GO:0016070 219 0.927
transcription dna templated GO:0006351 181 0.926
digestive tract morphogenesis GO:0048546 231 0.923
Fly
embryonic organ morphogenesis GO:0048562 274 0.919
Zebrafish Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.916
aromatic compound biosynthetic process GO:0019438 217 0.915
regulation of rna biosynthetic process GO:2001141 213 0.915
rna biosynthetic process GO:0032774 181 0.913
bmp signaling pathway GO:0030509 52 0.911
Mouse
determination of bilateral symmetry GO:0009855 204 0.909
digestive tract development GO:0048565 265 0.902
Fly
regulation of cellular biosynthetic process GO:0031326 245 0.898
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.889
Mouse Fly
regionalization GO:0003002 274 0.882
response to organic substance GO:0010033 153 0.869
Mouse
heterocycle biosynthetic process GO:0018130 215 0.856
signal transduction GO:0007165 455 0.854
Mouse
mesoderm development GO:0007498 88 0.854
nucleobase containing compound biosynthetic process GO:0034654 205 0.853
positive regulation of rna metabolic process GO:0051254 59 0.846
regulation of macromolecule metabolic process GO:0060255 317 0.838
sensory organ development GO:0007423 393 0.835
Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.831
positive regulation of macromolecule metabolic process GO:0010604 93 0.827
biosynthetic process GO:0009058 294 0.824
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.824
organic cyclic compound metabolic process GO:1901360 301 0.823
cell migration involved in gastrulation GO:0042074 79 0.806
cell surface receptor signaling pathway GO:0007166 325 0.798
Mouse
positive regulation of metabolic process GO:0009893 108 0.795
ear development GO:0043583 127 0.787
response to external stimulus GO:0009605 264 0.786
Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.779
negative regulation of biological process GO:0048519 304 0.777
Human Mouse Fly
gene expression GO:0010467 252 0.776
positive regulation of gene expression GO:0010628 71 0.776
heterocycle metabolic process GO:0046483 290 0.774
central nervous system development GO:0007417 387 0.768
positive regulation of cellular biosynthetic process GO:0031328 68 0.765
gastrulation GO:0007369 208 0.760
Fly
embryonic appendage morphogenesis GO:0035113 30 0.757
Mouse
nucleic acid metabolic process GO:0090304 244 0.757
death GO:0016265 121 0.751
Fly
blood vessel morphogenesis GO:0048514 216 0.747
nitrogen compound metabolic process GO:0006807 319 0.744
head development GO:0060322 303 0.738
regulation of nitrogen compound metabolic process GO:0051171 251 0.730
regulation of transcription dna templated GO:0006355 213 0.730
skeletal system development GO:0001501 181 0.719
embryonic skeletal system development GO:0048706 97 0.719
Zebrafish Mouse
regulation of developmental process GO:0050793 247 0.706
Mouse Worm Fly
negative regulation of gene expression GO:0010629 65 0.691
Human Mouse Fly
odontogenesis of dentin containing tooth GO:0042475 1 0.677
Mouse
eye development GO:0001654 277 0.677
Fly
chordate embryonic development GO:0043009 271 0.675
Zebrafish Mouse
appendage morphogenesis GO:0035107 56 0.669
Mouse
cartilage condensation GO:0001502 3 0.660
formation of primary germ layer GO:0001704 62 0.638
retina development in camera type eye GO:0060041 146 0.634
heart development GO:0007507 313 0.633
immune system process GO:0002376 241 0.630
Zebrafish Mouse Fly
apoptotic process GO:0006915 116 0.623
Fly
negative regulation of cellular metabolic process GO:0031324 77 0.623
Human Mouse Fly
embryonic limb morphogenesis GO:0030326 2 0.608
Mouse
determination of heart left right asymmetry GO:0061371 117 0.606
response to wounding GO:0009611 116 0.605
Fly
positive regulation of cellular process GO:0048522 201 0.599
aging GO:0007568 2 0.599
positive regulation of biosynthetic process GO:0009891 68 0.582
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.581
regulation of signal transduction GO:0009966 225 0.575
Mouse
wound healing GO:0042060 90 0.573
Fly
determination of left right symmetry GO:0007368 179 0.569
cellular nitrogen compound metabolic process GO:0034641 290 0.554
regulation of signaling GO:0023051 235 0.550
Mouse
locomotion GO:0040011 313 0.548
Fly
eye morphogenesis GO:0048592 144 0.545
Fly
morphogenesis of an epithelium GO:0002009 333 0.538
negative regulation of cellular process GO:0048523 283 0.535
Human Mouse Fly
regulation of multicellular organismal process GO:0051239 277 0.534
Mouse Worm Fly
chondrocyte development GO:0002063 4 0.530
Mouse
osteoblast differentiation GO:0001649 5 0.520
Human Mouse
ossification GO:0001503 23 0.515
Human Mouse
positive regulation of nucleic acid templated transcription GO:1903508 57 0.513
heart morphogenesis GO:0003007 156 0.511
regulation of cell death GO:0010941 103 0.506
Fly
cell death GO:0008219 121 0.500
Fly
ameboidal type cell migration GO:0001667 143 0.499
enzyme linked receptor protein signaling pathway GO:0007167 106 0.497
Mouse
negative regulation of macromolecule metabolic process GO:0010605 76 0.495
Human Mouse Fly
cartilage morphogenesis GO:0060536 13 0.486
positive regulation of biological process GO:0048518 253 0.477
negative regulation of signaling GO:0023057 96 0.473
Mouse
negative regulation of smoothened signaling pathway GO:0045879 6 0.462
Mouse
forebrain development GO:0030900 96 0.457
regulation of response to stimulus GO:0048583 269 0.453
Mouse
notochord development GO:0030903 54 0.446
mesenchymal cell proliferation GO:0010463 1 0.443
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.441
regulation of cartilage development GO:0061035 7 0.441
Mouse
camera type eye morphogenesis GO:0048593 108 0.440
heart looping GO:0001947 94 0.438
nucleobase containing compound metabolic process GO:0006139 274 0.436
tube morphogenesis GO:0035239 349 0.434
Fly
angiogenesis GO:0001525 158 0.433
bone development GO:0060348 14 0.430
Mouse
myotube cell development GO:0014904 35 0.421
regulation of anatomical structure morphogenesis GO:0022603 130 0.419
Mouse Fly
muscle tissue development GO:0060537 110 0.404
single organism metabolic process GO:0044710 217 0.400
positive regulation of cellular metabolic process GO:0031325 94 0.400
negative regulation of transcription dna templated GO:0045892 45 0.393
Human Mouse Fly
cellular component movement GO:0006928 335 0.391
Fly
larval development GO:0002164 2 0.385
appendage development GO:0048736 80 0.378
Mouse
nucleic acid templated transcription GO:0097659 181 0.377
neuron projection development GO:0031175 180 0.373
Fly
establishment of localization GO:0051234 244 0.368
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.367
Mouse Fly
fin development GO:0033333 77 0.366
blood vessel development GO:0001568 246 0.359
morphogenesis of an epithelial sheet GO:0002011 49 0.358
embryonic heart tube development GO:0035050 133 0.350
dorsal ventral pattern formation GO:0009953 125 0.349
mesoderm formation GO:0001707 43 0.348
tissue regeneration GO:0042246 74 0.341
response to chemical GO:0042221 320 0.333
Mouse Fly
skeletal system morphogenesis GO:0048705 102 0.333
Zebrafish Mouse
regulation of ossification GO:0030278 5 0.329
Mouse
growth GO:0040007 174 0.329
Worm
regulation of cell communication GO:0010646 232 0.327
Mouse
endodermal cell fate determination GO:0007493 2 0.324
convergent extension involved in gastrulation GO:0060027 71 0.314
regulation of multicellular organismal development GO:2000026 223 0.311
Mouse Fly
fin morphogenesis GO:0033334 53 0.310
regulation of nucleic acid templated transcription GO:1903506 213 0.300
muscle organ development GO:0007517 101 0.289
connective tissue development GO:0061448 99 0.289
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.288
Mouse
embryonic viscerocranium morphogenesis GO:0048703 52 0.284
Zebrafish
embryonic heart tube morphogenesis GO:0003143 108 0.284
stem cell proliferation GO:0072089 4 0.282
negative regulation of metabolic process GO:0009892 86 0.277
Human Mouse Fly
regulation of programmed cell death GO:0043067 101 0.275
Fly
cellular aromatic compound metabolic process GO:0006725 295 0.265
cell projection organization GO:0030030 284 0.264
Fly
negative regulation of signal transduction GO:0009968 94 0.264
Mouse
vasculature development GO:0001944 278 0.264
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.252
regulation of fibroblast growth factor receptor signaling pathway GO:0040036 20 0.247
Mouse
cell proliferation GO:0008283 80 0.245
Mouse
retina morphogenesis in camera type eye GO:0060042 79 0.242
defense response to other organism GO:0098542 33 0.240
cellular response to growth factor stimulus GO:0071363 39 0.239
Mouse
response to stress GO:0006950 263 0.238
Fly
cell migration GO:0016477 237 0.237
kupffer s vesicle development GO:0070121 50 0.235
blood circulation GO:0008015 87 0.232
transcription from rna polymerase ii promoter GO:0006366 80 0.231
Mouse Fly
organelle localization GO:0051640 49 0.230
nephron tubule morphogenesis GO:0072078 1 0.228
cell motility GO:0048870 244 0.227
embryonic hemopoiesis GO:0035162 53 0.226
Fly
fin regeneration GO:0031101 51 0.221
foregut morphogenesis GO:0007440 4 0.221
negative regulation of developmental process GO:0051093 65 0.218
cartilage development GO:0051216 96 0.216
positive regulation of developmental process GO:0051094 50 0.212
Mouse Worm Fly
single organism biosynthetic process GO:0044711 71 0.209
protein metabolic process GO:0019538 183 0.207
regulation of molecular function GO:0065009 70 0.205
trigeminal motor nucleus development GO:0021731 2 0.204
striated muscle cell development GO:0055002 108 0.200
regulation of endodermal cell fate specification GO:0042663 15 0.199
ear morphogenesis GO:0042471 64 0.199
positive regulation of transcription dna templated GO:0045893 57 0.198
positive regulation of cell cycle GO:0045787 3 0.197
negative regulation of response to stimulus GO:0048585 104 0.194
Mouse
regulation of cell differentiation GO:0045595 142 0.193
Mouse Fly
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.192
regulation of cell cycle GO:0051726 52 0.192
organelle organization GO:0006996 227 0.190
regulation of apoptotic process GO:0042981 98 0.189
Fly
macromolecule modification GO:0043412 111 0.189
myotube differentiation GO:0014902 45 0.187
cellular protein modification process GO:0006464 100 0.184
regulation of multicellular organism growth GO:0040014 4 0.184
Worm
cellular localization GO:0051641 97 0.182
medial fin development GO:0033338 16 0.181
macromolecular complex subunit organization GO:0043933 74 0.180
muscle fiber development GO:0048747 52 0.179
otic vesicle morphogenesis GO:0071600 34 0.174
regulation of phosphate metabolic process GO:0019220 43 0.172
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.165
embryonic skeletal system morphogenesis GO:0048704 93 0.164
Zebrafish Mouse
inner ear morphogenesis GO:0042472 63 0.163
cellular protein metabolic process GO:0044267 129 0.163
negative regulation of cell communication GO:0010648 96 0.159
Mouse
protein modification process GO:0036211 100 0.158
skeletal muscle fiber development GO:0048741 35 0.158
response to oxygen containing compound GO:1901700 55 0.157
bmp signaling pathway involved in heart jogging GO:0003303 14 0.155
specification of symmetry GO:0009799 204 0.153
negative regulation of multicellular organismal process GO:0051241 69 0.148
muscle structure development GO:0061061 196 0.147
regulation of cell development GO:0060284 100 0.146
Fly
g protein coupled receptor signaling pathway GO:0007186 74 0.146
cellular component morphogenesis GO:0032989 336 0.144
Fly
brain development GO:0007420 293 0.144
gastrulation with mouth forming second GO:0001702 44 0.143
positive regulation of signal transduction GO:0009967 56 0.142
positive regulation of signaling GO:0023056 56 0.139
inner ear development GO:0048839 126 0.139
endodermal cell differentiation GO:0035987 19 0.138
photoreceptor cell differentiation GO:0046530 55 0.135
Fly
heart formation GO:0060914 13 0.132
circulatory system process GO:0003013 87 0.128
convergent extension GO:0060026 118 0.128
morphogenesis of embryonic epithelium GO:0016331 30 0.127
system process GO:0003008 185 0.127
embryonic pattern specification GO:0009880 44 0.126
camera type eye development GO:0043010 222 0.125
regulation of organ morphogenesis GO:2000027 35 0.125
Mouse Fly
embryo development ending in birth or egg hatching GO:0009792 271 0.124
Zebrafish Mouse Worm
cell cycle GO:0007049 93 0.122
reproduction GO:0000003 40 0.121
Worm
skeletal muscle tissue development GO:0007519 67 0.121
nephron epithelium morphogenesis GO:0072088 1 0.120
determination of dorsal ventral asymmetry GO:0048262 34 0.120
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 15 0.119
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.119
Human Mouse Fly
cellular component biogenesis GO:0044085 178 0.118
cell part morphogenesis GO:0032990 246 0.117
Fly
wnt signaling pathway GO:0016055 80 0.117
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.114
endodermal cell fate specification GO:0001714 17 0.114
muscle cell differentiation GO:0042692 139 0.112
regulation of heart morphogenesis GO:2000826 17 0.112
cellular response to organic substance GO:0071310 105 0.110
Mouse
axon guidance GO:0007411 86 0.110
Fly
developmental growth GO:0048589 166 0.109
Worm
regeneration GO:0031099 91 0.108
response to endogenous stimulus GO:0009719 83 0.107
Mouse
multicellular organismal reproductive process GO:0048609 35 0.106
response to organic cyclic compound GO:0014070 51 0.106
response to growth factor GO:0070848 39 0.106
Mouse
organ formation GO:0048645 17 0.105
embryonic cranial skeleton morphogenesis GO:0048701 90 0.105
Zebrafish Mouse
neuron development GO:0048666 262 0.105
Fly
mesoderm morphogenesis GO:0048332 51 0.105
negative regulation of cell death GO:0060548 60 0.103
otic vesicle development GO:0071599 42 0.103
apoptotic process involved in morphogenesis GO:0060561 2 0.102
maintenance of location GO:0051235 4 0.102
stem cell differentiation GO:0048863 117 0.101
Mouse
positive regulation of cell death GO:0010942 29 0.100
Fly
endoderm development GO:0007492 49 0.100
endoderm formation GO:0001706 29 0.099
positive regulation of molecular function GO:0044093 33 0.098
lipid biosynthetic process GO:0008610 22 0.098
striated muscle tissue development GO:0014706 110 0.097
positive regulation of cell communication GO:0010647 56 0.096
bone morphogenesis GO:0060349 11 0.095
Mouse
regulation of protein metabolic process GO:0051246 56 0.095
small molecule metabolic process GO:0044281 77 0.095
programmed cell death GO:0012501 119 0.093
Fly
epiboly GO:0090504 41 0.092
bmp signaling pathway involved in heart development GO:0061312 15 0.091
proepicardium development GO:0003342 4 0.089
transport GO:0006810 220 0.089
positive regulation of response to stimulus GO:0048584 80 0.088
skeletal muscle organ development GO:0060538 78 0.087
cellular response to endogenous stimulus GO:0071495 68 0.087
Mouse
positive regulation of rna biosynthetic process GO:1902680 57 0.087
phosphorus metabolic process GO:0006793 109 0.087
regulation of nervous system development GO:0051960 90 0.086
cell morphogenesis involved in differentiation GO:0000904 195 0.084
Fly
response to abiotic stimulus GO:0009628 122 0.083
specification of organ identity GO:0010092 2 0.083
convergent extension involved in organogenesis GO:0060029 10 0.082
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.082
regulation of wnt signaling pathway calcium modulating pathway GO:0008591 3 0.082
regulation of embryonic development GO:0045995 47 0.081
striated muscle cell differentiation GO:0051146 129 0.081
establishment of spindle localization GO:0051293 12 0.078
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.077
Human Mouse Fly
palate development GO:0060021 8 0.076
regulation of mesenchymal cell proliferation GO:0010464 1 0.076
tissue remodeling GO:0048771 4 0.075
cellular component assembly GO:0022607 170 0.074
hematopoietic or lymphoid organ development GO:0048534 191 0.074
Zebrafish Mouse Fly
localization of cell GO:0051674 244 0.073
negative regulation of wnt signaling pathway GO:0030178 30 0.073
neuron differentiation GO:0030182 353 0.071
Fly
negative regulation of cell differentiation GO:0045596 46 0.070
regulation of growth GO:0040008 42 0.068
Worm
regulation of wnt signaling pathway GO:0030111 53 0.068
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.068
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.067
Mouse
cellular response to chemical stimulus GO:0070887 157 0.066
Mouse
gland development GO:0048732 143 0.066
regulation of cellular protein metabolic process GO:0032268 52 0.064
endocrine system development GO:0035270 65 0.064
positive regulation of multicellular organismal process GO:0051240 52 0.064
Mouse Worm Fly
hindbrain development GO:0030902 91 0.064
inner ear receptor cell differentiation GO:0060113 29 0.063
regulation of reproductive process GO:2000241 4 0.063
muscle cell development GO:0055001 115 0.062
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.061
cardiac atrium development GO:0003230 4 0.060
positive regulation of epithelial cell differentiation GO:0030858 2 0.060
lipid catabolic process GO:0016042 4 0.059
cell cell signaling GO:0007267 52 0.059
positive regulation of stem cell proliferation GO:2000648 1 0.059
chemotaxis GO:0006935 104 0.059
Fly
negative regulation of rna biosynthetic process GO:1902679 45 0.058
Human Mouse Fly
developmental programmed cell death GO:0010623 4 0.058
Fly
cell fate specification GO:0001708 68 0.058
positive regulation of cellular component biogenesis GO:0044089 3 0.058
cardiac atrium morphogenesis GO:0003209 2 0.058
ion homeostasis GO:0050801 41 0.057
regulation of stem cell differentiation GO:2000736 4 0.057
medial fin morphogenesis GO:0035141 14 0.057
developmental growth involved in morphogenesis GO:0060560 86 0.056
mesodermal cell fate commitment GO:0001710 14 0.056
regulation of phosphorus metabolic process GO:0051174 43 0.055
glomerular basement membrane development GO:0032836 5 0.055
regulation of biological quality GO:0065008 263 0.055
regulation of localization GO:0032879 104 0.054
endocardium development GO:0003157 9 0.054
protein kinase b signaling GO:0043491 9 0.054
lateral line development GO:0048882 66 0.054
embryonic camera type eye morphogenesis GO:0048596 19 0.053
phosphate containing compound metabolic process GO:0006796 108 0.053
regulation of cell fate specification GO:0042659 20 0.052
phosphorylation GO:0016310 69 0.052
regulation of tube size GO:0035150 2 0.051
negative regulation of rna metabolic process GO:0051253 48 0.050
Human Mouse Fly
protein phosphorylation GO:0006468 47 0.050
single organism cell adhesion GO:0098602 29 0.050
cellular response to external stimulus GO:0071496 2 0.049
hepatocyte proliferation GO:0072574 2 0.048
diterpenoid catabolic process GO:0016103 2 0.048
response to hormone GO:0009725 48 0.047
developmental induction GO:0031128 10 0.047
urogenital system development GO:0001655 97 0.047
apoptotic process involved in development GO:1902742 2 0.047
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.046
Fly
extracellular structure organization GO:0043062 27 0.046
regulation of intracellular signal transduction GO:1902531 57 0.046
protein complex subunit organization GO:0071822 46 0.046
multicellular organismal homeostasis GO:0048871 29 0.046
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.046
negative regulation of feeding behavior GO:2000252 2 0.046
abducens nerve development GO:0021560 1 0.046
embryonic eye morphogenesis GO:0048048 30 0.046
positive regulation of muscle organ development GO:0048636 1 0.044
response to mechanical stimulus GO:0009612 24 0.044
cell morphogenesis GO:0000902 289 0.044
Fly
negative regulation of apoptotic process GO:0043066 55 0.043
embryonic skeletal joint development GO:0072498 3 0.043
regulation of cellular component organization GO:0051128 86 0.043
terpenoid catabolic process GO:0016115 2 0.042
embryonic neurocranium morphogenesis GO:0048702 15 0.042
floor plate formation GO:0021508 12 0.042
spinal cord anterior posterior patterning GO:0021512 1 0.042
nephron development GO:0072006 31 0.042
multi organism process GO:0051704 134 0.042
pectoral fin development GO:0033339 50 0.042
defense response to bacterium GO:0042742 22 0.042
somitogenesis GO:0001756 87 0.042
negative regulation of biosynthetic process GO:0009890 55 0.042
Human Mouse Fly
response to bacterium GO:0009617 58 0.041
axon development GO:0061564 166 0.040
Fly
regulation of mesodermal cell fate specification GO:0042661 9 0.040
positive regulation of cell differentiation GO:0045597 30 0.039
Mouse Fly
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.039
positive regulation of cellular protein metabolic process GO:0032270 22 0.039
heart jogging GO:0003146 40 0.039
response to lipid GO:0033993 60 0.038
regulation of heart growth GO:0060420 2 0.038
single organism localization GO:1902578 225 0.038
fibroblast growth factor receptor signaling pathway GO:0008543 22 0.037
Mouse
cellular homeostasis GO:0019725 26 0.037
single organism behavior GO:0044708 24 0.037
regulation of blood circulation GO:1903522 32 0.037
macromolecule localization GO:0033036 54 0.037
defense response GO:0006952 47 0.036
establishment of organelle localization GO:0051656 45 0.036
cell migration to the midline involved in heart development GO:0003318 12 0.036
intracellular transport GO:0046907 32 0.036
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.036
Human Mouse Fly
semicircular canal formation GO:0060876 4 0.036
ectodermal placode morphogenesis GO:0071697 32 0.036
anterior posterior pattern specification GO:0009952 152 0.036
epithelial tube morphogenesis GO:0060562 148 0.035
regulation of cellular response to drug GO:2001038 1 0.035
liver development GO:0001889 96 0.035
regulation of cell proliferation GO:0042127 37 0.035
Mouse
single organismal cell cell adhesion GO:0016337 29 0.035
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.035
cardiogenic plate morphogenesis GO:0003142 1 0.035
cellular response to vitamin a GO:0071299 1 0.035
glomerulus vasculature development GO:0072012 2 0.034
fat soluble vitamin catabolic process GO:0042363 2 0.034
biological adhesion GO:0022610 40 0.034
axonogenesis GO:0007409 152 0.034
Fly
cellular response to extracellular stimulus GO:0031668 2 0.034
immune system development GO:0002520 191 0.033
Zebrafish Mouse Fly
positive regulation of cellular catabolic process GO:0031331 3 0.033
oocyte maturation GO:0001556 4 0.033
regulation of anterior head development GO:2000742 2 0.033
mesodermal endodermal cell signaling GO:0003131 1 0.033
positive regulation of protein metabolic process GO:0051247 23 0.032
multicellular organism reproduction GO:0032504 35 0.032
negative regulation of cellular biosynthetic process GO:0031327 55 0.032
Human Mouse Fly
hepaticobiliary system development GO:0061008 98 0.032
regulation of mitotic cell cycle GO:0007346 25 0.032
cellular protein catabolic process GO:0044257 4 0.032
cellular response to organic cyclic compound GO:0071407 38 0.031
kidney development GO:0001822 92 0.031
single organism cellular localization GO:1902580 46 0.030
astrocyte differentiation GO:0048708 1 0.030
negative regulation of nucleic acid templated transcription GO:1903507 45 0.030
Human Mouse Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.029
Human Mouse Fly
regulation of bmp signaling pathway GO:0030510 39 0.029
negative regulation of nervous system development GO:0051961 22 0.029
response to fibroblast growth factor GO:0071774 22 0.029
Mouse
posterior commissure morphogenesis GO:0021961 1 0.029
organic hydroxy compound biosynthetic process GO:1901617 6 0.029
limb morphogenesis GO:0035108 7 0.029
Mouse
stem cell division GO:0017145 1 0.028
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.028
hemopoiesis GO:0030097 183 0.028
Zebrafish Mouse Fly
organonitrogen compound metabolic process GO:1901564 74 0.027
vitamin catabolic process GO:0009111 2 0.027
hatching GO:0035188 4 0.027
Worm
regulation of endodermal cell differentiation GO:1903224 15 0.027
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.027
Mouse
chondrocyte differentiation GO:0002062 7 0.027
dorsal convergence GO:0060030 14 0.027
inner ear receptor cell development GO:0060119 20 0.026
regulation of gastrulation GO:0010470 24 0.026
establishment of localization in cell GO:0051649 77 0.026
response to external biotic stimulus GO:0043207 97 0.026
cognition GO:0050890 1 0.026
regulation of epithelial to mesenchymal transition GO:0010717 3 0.026
cell fate commitment GO:0045165 99 0.026
Mouse
positive regulation of cell proliferation GO:0008284 15 0.025
Mouse
generation of neurons GO:0048699 385 0.025
Fly

runx2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
osteochondrodysplasia DOID:2256 0 0.678
Human
bone development disease DOID:0080006 0 0.678
Human
bone disease DOID:0080001 0 0.678
Human
disease of anatomical entity DOID:7 0 0.678
Human
musculoskeletal system disease DOID:17 0 0.678
Human
connective tissue disease DOID:65 0 0.678
Human
acrocephalosyndactylia DOID:12960 0 0.080
dysostosis DOID:1934 0 0.080
synostosis DOID:11971 0 0.080
cleidocranial dysplasia DOID:13994 0 0.075
Human
orofacial cleft DOID:0050567 0 0.073
physical disorder DOID:0080015 0 0.073
pfeiffer syndrome DOID:14705 0 0.063
congenital heart disease DOID:1682 0 0.051
heart septal defect DOID:1681 0 0.051
atrioventricular septal defect DOID:0050651 0 0.051
heart disease DOID:114 0 0.051
cardiovascular system disease DOID:1287 0 0.051
syndrome DOID:225 0 0.049
tooth and nail syndrome DOID:6678 0 0.049
malignant mesothelioma DOID:1790 0 0.046
cancer DOID:162 0 0.046
disease of cellular proliferation DOID:14566 0 0.046
cell type cancer DOID:0050687 0 0.046
visual pathway disease DOID:1393 0 0.037
sensory system disease DOID:0050155 0 0.037
eye and adnexa disease DOID:1492 0 0.037
nervous system disease DOID:863 0 0.037
eye disease DOID:5614 0 0.037
iris disease DOID:240 0 0.028
uveal disease DOID:3480 0 0.028
aniridia DOID:12271 0 0.028
coloboma of optic nerve DOID:11975 0 0.027