Danio rerio

0 known processes

ryr2b

ryanodine receptor 2b (cardiac)

ryr2b biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
central nervous system development GO:0007417 387 0.412
heart development GO:0007507 313 0.374
nitrogen compound metabolic process GO:0006807 319 0.366
cellular nitrogen compound metabolic process GO:0034641 290 0.347
muscle cell differentiation GO:0042692 139 0.324
determination of bilateral symmetry GO:0009855 204 0.322
sensory organ development GO:0007423 393 0.317
muscle structure development GO:0061061 196 0.312
embryonic heart tube development GO:0035050 133 0.285
macromolecule biosynthetic process GO:0009059 227 0.265
aging GO:0007568 2 0.260
regulation of cellular biosynthetic process GO:0031326 245 0.258
regulation of blood pressure GO:0008217 1 0.249
regulation of primary metabolic process GO:0080090 311 0.235
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.226
fin development GO:0033333 77 0.213
regulation of nitrogen compound metabolic process GO:0051171 251 0.209
behavior GO:0007610 74 0.200
muscle organ development GO:0007517 101 0.199
regulation of rna metabolic process GO:0051252 224 0.185
embryonic organ development GO:0048568 381 0.169
specification of symmetry GO:0009799 204 0.164
circulatory system process GO:0003013 87 0.158
biosynthetic process GO:0009058 294 0.157
striated muscle cell differentiation GO:0051146 129 0.151
response to chemical GO:0042221 320 0.150
blood circulation GO:0008015 87 0.149
maintenance of location GO:0051235 4 0.148
brain development GO:0007420 293 0.146
cognition GO:0050890 1 0.143
g protein coupled receptor signaling pathway GO:0007186 74 0.142
signal transduction GO:0007165 455 0.139
organic cyclic compound metabolic process GO:1901360 301 0.139
striated muscle tissue development GO:0014706 110 0.129
organonitrogen compound metabolic process GO:1901564 74 0.125
determination of heart left right asymmetry GO:0061371 117 0.124
organic substance biosynthetic process GO:1901576 289 0.124
heterocycle metabolic process GO:0046483 290 0.122
muscle tissue development GO:0060537 110 0.120
system process GO:0003008 185 0.117
regulation of cell communication GO:0010646 232 0.110
regulation of signaling GO:0023051 235 0.102
embryo development ending in birth or egg hatching GO:0009792 271 0.101
establishment of protein localization to organelle GO:0072594 4 0.101
heterocycle biosynthetic process GO:0018130 215 0.101
regulation of signal transduction GO:0009966 225 0.100
skeletal system development GO:0001501 181 0.099
appendage development GO:0048736 80 0.098
response to alkaloid GO:0043279 2 0.096
cellular nitrogen compound biosynthetic process GO:0044271 218 0.091
striated muscle cell development GO:0055002 108 0.088
lipid storage GO:0019915 1 0.088
regulation of cellular metabolic process GO:0031323 320 0.088
homeostatic process GO:0042592 142 0.088
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.085
regulation of multicellular organismal development GO:2000026 223 0.084
protein targeting to nucleus GO:0044744 3 0.084
muscle cell development GO:0055001 115 0.083
determination of left right symmetry GO:0007368 179 0.083
regulation of sequestering of calcium ion GO:0051282 4 0.082
mesenchyme development GO:0060485 127 0.081
organic cyclic compound biosynthetic process GO:1901362 223 0.080
mesoderm development GO:0007498 88 0.079
cellular component movement GO:0006928 335 0.078
regulation of biosynthetic process GO:0009889 250 0.078
regulation of system process GO:0044057 40 0.078
positive regulation of biological process GO:0048518 253 0.078
negative regulation of cellular process GO:0048523 283 0.077
head development GO:0060322 303 0.075
embryonic organ morphogenesis GO:0048562 274 0.074
cell surface receptor signaling pathway GO:0007166 325 0.071
locomotion GO:0040011 313 0.070
cellular component biogenesis GO:0044085 178 0.069
cellular response to chemical stimulus GO:0070887 157 0.067
endocrine system development GO:0035270 65 0.066
regulation of biological quality GO:0065008 263 0.065
cellular aromatic compound metabolic process GO:0006725 295 0.065
transcription dna templated GO:0006351 181 0.063
cellular component morphogenesis GO:0032989 336 0.063
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.063
nucleic acid metabolic process GO:0090304 244 0.062
eye morphogenesis GO:0048592 144 0.062
hemopoiesis GO:0030097 183 0.062
cytosolic calcium ion transport GO:0060401 3 0.061
cellular macromolecule biosynthetic process GO:0034645 224 0.060
embryonic heart tube morphogenesis GO:0003143 108 0.060
spinal cord development GO:0021510 46 0.059
regulation of metal ion transport GO:0010959 4 0.059
heart looping GO:0001947 94 0.058
retina development in camera type eye GO:0060041 146 0.057
neurotransmitter transport GO:0006836 2 0.057
regulation of ion transmembrane transporter activity GO:0032412 2 0.056
carbohydrate derivative metabolic process GO:1901135 61 0.054
single organism metabolic process GO:0044710 217 0.053
nucleobase containing compound metabolic process GO:0006139 274 0.053
regulation of response to stimulus GO:0048583 269 0.052
calcium ion homeostasis GO:0055074 19 0.052
cellular amide metabolic process GO:0043603 4 0.052
response to oxygen levels GO:0070482 25 0.050
positive regulation of cellular process GO:0048522 201 0.049
cation homeostasis GO:0055080 33 0.049
transmembrane transport GO:0055085 120 0.048
retina morphogenesis in camera type eye GO:0060042 79 0.048
rna biosynthetic process GO:0032774 181 0.048
rna metabolic process GO:0016070 219 0.048
cellular response to endogenous stimulus GO:0071495 68 0.048
regulation of cell fate specification GO:0042659 20 0.048
response to abiotic stimulus GO:0009628 122 0.047
hematopoietic or lymphoid organ development GO:0048534 191 0.047
skeletal muscle organ development GO:0060538 78 0.047
aromatic compound biosynthetic process GO:0019438 217 0.047
neuron differentiation GO:0030182 353 0.047
urogenital system development GO:0001655 97 0.047
stem cell differentiation GO:0048863 117 0.046
multi organism process GO:0051704 134 0.046
regulation of transmembrane transport GO:0034762 18 0.046
positive regulation of biosynthetic process GO:0009891 68 0.045
single organism organelle organization GO:1902589 199 0.044
cellular macromolecule metabolic process GO:0044260 391 0.044
developmental growth GO:0048589 166 0.044
apoptotic process GO:0006915 116 0.044
camera type eye development GO:0043010 222 0.043
establishment of localization in cell GO:0051649 77 0.042
cardiac muscle cell development GO:0055013 20 0.042
connective tissue development GO:0061448 99 0.042
cardiac muscle tissue development GO:0048738 48 0.041
single organism localization GO:1902578 225 0.041
tube morphogenesis GO:0035239 349 0.041
reproductive process GO:0022414 40 0.041
morphogenesis of an epithelium GO:0002009 333 0.041
death GO:0016265 121 0.040
regulation of purine nucleotide catabolic process GO:0033121 2 0.040
somitogenesis GO:0001756 87 0.040
heart morphogenesis GO:0003007 156 0.040
nucleocytoplasmic transport GO:0006913 4 0.039
positive regulation of transport GO:0051050 2 0.039
small molecule metabolic process GO:0044281 77 0.039
organic acid metabolic process GO:0006082 31 0.038
heart contraction GO:0060047 71 0.037
multi organism reproductive process GO:0044703 36 0.037
fin morphogenesis GO:0033334 53 0.037
lateral line development GO:0048882 66 0.037
response to glucocorticoid GO:0051384 1 0.036
regulation of apoptotic process GO:0042981 98 0.036
cellular response to organic substance GO:0071310 105 0.035
positive regulation of camp biosynthetic process GO:0030819 2 0.034
larval development GO:0002164 2 0.034
cell motility GO:0048870 244 0.033
sequestering of metal ion GO:0051238 3 0.033
regulation of systemic arterial blood pressure GO:0003073 1 0.033
response to endogenous stimulus GO:0009719 83 0.033
response to organic substance GO:0010033 153 0.033
nucleic acid templated transcription GO:0097659 181 0.032
regulation of developmental process GO:0050793 247 0.032
negative regulation of secretion by cell GO:1903531 2 0.032
protein localization to nucleus GO:0034504 3 0.032
nuclear transport GO:0051169 4 0.032
skeletal system morphogenesis GO:0048705 102 0.031
regulation of transcription dna templated GO:0006355 213 0.031
myotube cell development GO:0014904 35 0.031
chordate embryonic development GO:0043009 271 0.030
regulation of metabolic process GO:0019222 359 0.030
cell death GO:0008219 121 0.030
angiogenesis GO:0001525 158 0.030
gastrulation GO:0007369 208 0.030
heart process GO:0003015 71 0.030
cell migration GO:0016477 237 0.030
pancreas development GO:0031016 84 0.029
regulation of tube size GO:0035150 2 0.029
regulation of anatomical structure morphogenesis GO:0022603 130 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.029
regulation of protein import into nucleus GO:0042306 2 0.028
ion homeostasis GO:0050801 41 0.028
nuclear import GO:0051170 3 0.028
sensory organ morphogenesis GO:0090596 200 0.028
gene expression GO:0010467 252 0.027
modification dependent protein catabolic process GO:0019941 3 0.027
cellular cation homeostasis GO:0030003 17 0.027
metal ion homeostasis GO:0055065 26 0.027
cell projection organization GO:0030030 284 0.027
periodic partitioning GO:0007365 1 0.027
digestive tract development GO:0048565 265 0.027
neuron development GO:0048666 262 0.027
regulation of ion transmembrane transport GO:0034765 18 0.027
positive regulation of cellular biosynthetic process GO:0031328 68 0.027
cell proliferation GO:0008283 80 0.027
post embryonic morphogenesis GO:0009886 4 0.027
mitochondrion organization GO:0007005 4 0.026
cellular response to organic cyclic compound GO:0071407 38 0.026
cellular localization GO:0051641 97 0.026
regulation of protein complex assembly GO:0043254 3 0.026
cellular component assembly GO:0022607 170 0.026
regulation of nucleoside metabolic process GO:0009118 2 0.025
multicellular organism growth GO:0035264 4 0.025
regulation of cell development GO:0060284 100 0.025
blood vessel development GO:0001568 246 0.025
cellular component assembly involved in morphogenesis GO:0010927 107 0.025
modification dependent macromolecule catabolic process GO:0043632 3 0.025
calcium ion import GO:0070509 4 0.025
gland development GO:0048732 143 0.025
regulation of neurotransmitter transport GO:0051588 1 0.025
heart jogging GO:0003146 40 0.025
regulation of transmembrane transporter activity GO:0022898 2 0.025
regulation of protein transport GO:0051223 3 0.025
peptide metabolic process GO:0006518 1 0.024
sexual reproduction GO:0019953 36 0.024
energy reserve metabolic process GO:0006112 2 0.024
regulation of fatty acid metabolic process GO:0019217 1 0.024
transcription from rna polymerase ii promoter GO:0006366 80 0.024
ear development GO:0043583 127 0.023
organelle organization GO:0006996 227 0.023
immune system development GO:0002520 191 0.023
protein secretion GO:0009306 1 0.023
regulation of gene expression GO:0010468 265 0.023
regulation of multicellular organismal process GO:0051239 277 0.023
response to stress GO:0006950 263 0.022
positive regulation of rna biosynthetic process GO:1902680 57 0.022
cartilage development GO:0051216 96 0.022
multicellular organismal reproductive process GO:0048609 35 0.022
regulation of macromolecule biosynthetic process GO:0010556 225 0.022
regulation of protein localization to nucleus GO:1900180 2 0.022
cation transport GO:0006812 81 0.022
regulation of cytokine production GO:0001817 3 0.022
regulation of transporter activity GO:0032409 2 0.022
regulation of organ growth GO:0046620 3 0.022
anterior posterior pattern specification GO:0009952 152 0.022
cellular protein catabolic process GO:0044257 4 0.022
ubiquitin dependent protein catabolic process GO:0006511 3 0.021
vasculature development GO:0001944 278 0.021
localization of cell GO:0051674 244 0.021
release of sequestered calcium ion into cytosol GO:0051209 3 0.021
positive regulation of catabolic process GO:0009896 4 0.021
photoreceptor cell fate commitment GO:0046552 1 0.021
enzyme linked receptor protein signaling pathway GO:0007167 106 0.021
regulation of multicellular organismal metabolic process GO:0044246 2 0.021
nitric oxide metabolic process GO:0046209 2 0.021
protein import into nucleus GO:0006606 3 0.021
reactive nitrogen species metabolic process GO:2001057 0 0.020
pectoral fin morphogenesis GO:0035138 29 0.020
nitric oxide biosynthetic process GO:0006809 2 0.020
calcium ion transport into cytosol GO:0060402 3 0.020
inner ear development GO:0048839 126 0.020
growth GO:0040007 174 0.020
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.020
single organism biosynthetic process GO:0044711 71 0.020
negative regulation of protein localization to nucleus GO:1900181 2 0.020
cytokinesis GO:0000910 3 0.020
protein import GO:0017038 3 0.020
response to steroid hormone GO:0048545 35 0.019
metal ion transport GO:0030001 58 0.019
regulation of macromolecule metabolic process GO:0060255 317 0.019
response to corticosteroid GO:0031960 1 0.019
regulation of blood vessel size GO:0050880 2 0.019
protein complex subunit organization GO:0071822 46 0.019
cellular amine metabolic process GO:0044106 2 0.019
cellular calcium ion homeostasis GO:0006874 13 0.019
adult behavior GO:0030534 2 0.019
organonitrogen compound biosynthetic process GO:1901566 47 0.019
intracellular receptor signaling pathway GO:0030522 30 0.018
sensory system development GO:0048880 76 0.018
negative regulation of biological process GO:0048519 304 0.018
cardiac cell development GO:0055006 21 0.018
ion transport GO:0006811 114 0.018
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.018
immune system process GO:0002376 241 0.018
regulation of cell activation GO:0050865 1 0.018
cellular ketone metabolic process GO:0042180 11 0.018
single organism cellular localization GO:1902580 46 0.018
positive regulation of signal transduction GO:0009967 56 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.018
photoreceptor cell differentiation GO:0046530 55 0.018
eye development GO:0001654 277 0.018
negative regulation of blood circulation GO:1903523 2 0.018
ameboidal type cell migration GO:0001667 143 0.018
positive regulation of gene expression GO:0010628 71 0.018
development of primary female sexual characteristics GO:0046545 4 0.018
regulation of multicellular organism growth GO:0040014 4 0.017
regulation of receptor activity GO:0010469 2 0.017
myotube differentiation GO:0014902 45 0.017
regulation of neurological system process GO:0031644 2 0.017
single organism nuclear import GO:1902593 3 0.017
regulation of programmed cell death GO:0043067 101 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
response to lipid GO:0033993 60 0.017
response to organic cyclic compound GO:0014070 51 0.017
regulation of striated muscle tissue development GO:0016202 6 0.017
developmental programmed cell death GO:0010623 4 0.017
antimicrobial humoral response GO:0019730 2 0.017
female gonad development GO:0008585 4 0.017
protein heterooligomerization GO:0051291 1 0.017
alcohol biosynthetic process GO:0046165 2 0.017
cellular response to light stimulus GO:0071482 4 0.017
polyol metabolic process GO:0019751 1 0.017
embryonic skeletal system morphogenesis GO:0048704 93 0.016
meiotic nuclear division GO:0007126 4 0.016
digestive tract morphogenesis GO:0048546 231 0.016
positive regulation of neuron migration GO:2001224 2 0.016
multicellular organism reproduction GO:0032504 35 0.016
positive regulation of cell communication GO:0010647 56 0.016
segmentation GO:0035282 97 0.016
circadian sleep wake cycle process GO:0022410 2 0.016
neurological system process GO:0050877 62 0.016
neuromast development GO:0048884 46 0.016
muscle fiber development GO:0048747 52 0.016
somite development GO:0061053 96 0.016
peptide transport GO:0015833 1 0.016
neurotransmitter secretion GO:0007269 2 0.016
regulation of embryonic development GO:0045995 47 0.016
tissue regeneration GO:0042246 74 0.016
cell differentiation in spinal cord GO:0021515 40 0.016
cellular response to radiation GO:0071478 4 0.016
embryonic skeletal system development GO:0048706 97 0.015
negative regulation of cell death GO:0060548 60 0.015
regulation of intracellular protein transport GO:0033157 3 0.015
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.015
regulation of cytoplasmic transport GO:1903649 4 0.015
skeletal muscle tissue development GO:0007519 67 0.015
sequestering of calcium ion GO:0051208 3 0.015
notochord development GO:0030903 54 0.015
mesodermal cell migration GO:0008078 12 0.015
diencephalon development GO:0021536 58 0.015
chemical homeostasis GO:0048878 49 0.015
carbohydrate biosynthetic process GO:0016051 1 0.015
negative regulation of protein transport GO:0051224 3 0.015
chemosensory behavior GO:0007635 1 0.015
positive regulation of metabolic process GO:0009893 108 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
single organism transport GO:0044765 206 0.015
positive regulation of cellular catabolic process GO:0031331 3 0.014
negative regulation of apoptotic process GO:0043066 55 0.014
regulation of synapse organization GO:0050807 3 0.014
regulation of establishment of protein localization GO:0070201 4 0.014
tissue remodeling GO:0048771 4 0.014
endoderm development GO:0007492 49 0.014
negative regulation of sequestering of calcium ion GO:0051283 4 0.014
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.014
cell cell signaling GO:0007267 52 0.014
erythrocyte differentiation GO:0030218 54 0.014
stem cell proliferation GO:0072089 4 0.014
positive regulation of transcription dna templated GO:0045893 57 0.014
wound healing GO:0042060 90 0.014
response to drug GO:0042493 3 0.014
regulation of heart contraction GO:0008016 32 0.014
regulation of reproductive process GO:2000241 4 0.014
embryonic neurocranium morphogenesis GO:0048702 15 0.014
regulation of hydrolase activity GO:0051336 28 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.014
skeletal muscle fiber development GO:0048741 35 0.014
positive regulation of cellular metabolic process GO:0031325 94 0.014
generation of neurons GO:0048699 385 0.014
cardiocyte differentiation GO:0035051 44 0.014
regulation of stem cell differentiation GO:2000736 4 0.013
negative regulation of cellular biosynthetic process GO:0031327 55 0.013
cartilage morphogenesis GO:0060536 13 0.013
cellular biosynthetic process GO:0044249 286 0.013
glucose homeostasis GO:0042593 1 0.013
eye photoreceptor cell differentiation GO:0001754 45 0.013
dna templated transcription initiation GO:0006352 1 0.013
oxoacid metabolic process GO:0043436 31 0.013
liver development GO:0001889 96 0.013
regulation of cell differentiation GO:0045595 142 0.013
lateral line system development GO:0048925 76 0.013
digestive system development GO:0055123 289 0.013
neuron projection development GO:0031175 180 0.013
positive regulation of macromolecule metabolic process GO:0010604 93 0.013
hormone secretion GO:0046879 2 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
regulation of reactive oxygen species metabolic process GO:2000377 2 0.013
regulation of protein targeting GO:1903533 2 0.013
regulation of stem cell proliferation GO:0072091 2 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.013
aorta development GO:0035904 4 0.013
regulation of nucleocytoplasmic transport GO:0046822 2 0.013
establishment of localization GO:0051234 244 0.013
negative regulation of feeding behavior GO:2000252 2 0.012
stem cell development GO:0048864 82 0.012
regulation of phosphate metabolic process GO:0019220 43 0.012
dorsal ventral pattern formation GO:0009953 125 0.012
camp biosynthetic process GO:0006171 11 0.012
regulation of calcium ion transport GO:0051924 2 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
female sex differentiation GO:0046660 4 0.012
muscle hypertrophy GO:0014896 2 0.012
cardiac muscle cell differentiation GO:0055007 30 0.012
positive regulation of carbohydrate metabolic process GO:0045913 1 0.012
amine metabolic process GO:0009308 2 0.012
cell fate commitment GO:0045165 99 0.012
homeostasis of number of cells GO:0048872 62 0.012
positive regulation of cell division GO:0051781 2 0.012
appendage morphogenesis GO:0035107 56 0.012
regulation of cellular component movement GO:0051270 55 0.012
negative regulation of metabolic process GO:0009892 86 0.012
nucleobase containing compound biosynthetic process GO:0034654 205 0.012
fin regeneration GO:0031101 51 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
regulation of locomotion GO:0040012 55 0.012
cation transmembrane transport GO:0098655 65 0.012
pectoral fin development GO:0033339 50 0.011
reproduction GO:0000003 40 0.011
regulation of ion transport GO:0043269 22 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
proteasomal protein catabolic process GO:0010498 2 0.011
extracellular matrix organization GO:0030198 27 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
mechanosensory lateral line system development GO:0048881 49 0.011
water homeostasis GO:0030104 4 0.011
regulation of cellular response to growth factor stimulus GO:0090287 35 0.011
cell part morphogenesis GO:0032990 246 0.011
regulation of sodium ion transmembrane transport GO:1902305 1 0.011
sensory perception of pain GO:0019233 1 0.011
kidney development GO:0001822 92 0.011
response to external stimulus GO:0009605 264 0.011
regulation of translational initiation GO:0006446 1 0.011
cell division GO:0051301 20 0.011
single organism reproductive process GO:0044702 40 0.011
regulation of cell fate commitment GO:0010453 22 0.011
cellular response to steroid hormone stimulus GO:0071383 31 0.011
positive regulation of chromosome organization GO:2001252 1 0.011
embryonic hemopoiesis GO:0035162 53 0.011
renal system development GO:0072001 94 0.011
macromolecular complex assembly GO:0065003 35 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.010
carbohydrate homeostasis GO:0033500 1 0.010
transport GO:0006810 220 0.010
negative regulation of cellular metabolic process GO:0031324 77 0.010
positive regulation of camp metabolic process GO:0030816 2 0.010
negative regulation of catabolic process GO:0009895 3 0.010
positive regulation of rna metabolic process GO:0051254 59 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.010
pyruvate metabolic process GO:0006090 1 0.010
regulation of hormone secretion GO:0046883 2 0.010
ovulation cycle GO:0042698 2 0.010

ryr2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.060
disease of metabolism DOID:0014667 0 0.038
cardiovascular system disease DOID:1287 0 0.028
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
nervous system disease DOID:863 0 0.010