Danio rerio

35 known processes

sae1

SUMO1 activating enzyme subunit 1

(Aliases: uble1a,sae2a,wu:fa28b04,zgc:86633)

sae1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.692
Worm
cellular aromatic compound metabolic process GO:0006725 295 0.664
Fly
meiotic nuclear division GO:0007126 4 0.573
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.569
Fly
heterocycle metabolic process GO:0046483 290 0.534
Fly
cell cycle GO:0007049 93 0.497
Fly
nucleobase containing compound metabolic process GO:0006139 274 0.495
Fly
nucleic acid metabolic process GO:0090304 244 0.453
Fly
gene expression GO:0010467 252 0.449
Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.430
Fly
central nervous system development GO:0007417 387 0.404
immune system process GO:0002376 241 0.401
hemopoiesis GO:0030097 183 0.377
nitrogen compound metabolic process GO:0006807 319 0.350
Fly
single organism organelle organization GO:1902589 199 0.347
organelle organization GO:0006996 227 0.289
regulation of metabolic process GO:0019222 359 0.283
Fly
single organism localization GO:1902578 225 0.261
rna metabolic process GO:0016070 219 0.246
Fly
single organism metabolic process GO:0044710 217 0.230
regulation of rna metabolic process GO:0051252 224 0.215
Fly
hematopoietic or lymphoid organ development GO:0048534 191 0.214
organic cyclic compound metabolic process GO:1901360 301 0.202
Fly
rna biosynthetic process GO:0032774 181 0.197
Fly
negative regulation of biological process GO:0048519 304 0.181
nuclear transport GO:0051169 4 0.180
negative regulation of cellular process GO:0048523 283 0.178
cellular nitrogen compound biosynthetic process GO:0044271 218 0.174
Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.167
Fly
regulation of cell cycle GO:0051726 52 0.162
Fly
regionalization GO:0003002 274 0.153
positive regulation of cellular process GO:0048522 201 0.146
regulation of mitotic cell cycle GO:0007346 25 0.145
Fly
regulation of chromosome segregation GO:0051983 1 0.145
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.144
positive regulation of biological process GO:0048518 253 0.143
Fly
aromatic compound biosynthetic process GO:0019438 217 0.134
Fly
mitotic dna damage checkpoint GO:0044773 4 0.129
regulation of nitrogen compound metabolic process GO:0051171 251 0.125
Fly
mitotic cell cycle GO:0000278 64 0.116
Fly
digestive system development GO:0055123 289 0.111
mitotic nuclear division GO:0007067 18 0.110
nucleic acid templated transcription GO:0097659 181 0.109
Fly
sensory organ development GO:0007423 393 0.107
immune system development GO:0002520 191 0.101
establishment of protein localization to organelle GO:0072594 4 0.098
cellular localization GO:0051641 97 0.098
regulation of developmental process GO:0050793 247 0.098
regulation of nucleic acid templated transcription GO:1903506 213 0.097
Fly
signal transduction GO:0007165 455 0.097
establishment of localization GO:0051234 244 0.097
single organism cellular localization GO:1902580 46 0.097
negative regulation of cell cycle phase transition GO:1901988 5 0.096
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.092
intracellular signal transduction GO:0035556 85 0.092
positive regulation of macromolecule metabolic process GO:0010604 93 0.091
organic cyclic compound biosynthetic process GO:1901362 223 0.091
Fly
transport GO:0006810 220 0.091
organelle fission GO:0048285 23 0.091
aging GO:0007568 2 0.091
response to temperature stimulus GO:0009266 15 0.087
generation of neurons GO:0048699 385 0.085
cell projection organization GO:0030030 284 0.084
response to stress GO:0006950 263 0.083
heart development GO:0007507 313 0.083
regulation of establishment of protein localization GO:0070201 4 0.083
determination of bilateral symmetry GO:0009855 204 0.079
locomotion GO:0040011 313 0.078
heterocycle biosynthetic process GO:0018130 215 0.078
Fly
regulation of cell differentiation GO:0045595 142 0.078
programmed cell death GO:0012501 119 0.076
regulation of cell proliferation GO:0042127 37 0.074
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.073
regulation of cellular metabolic process GO:0031323 320 0.069
Fly
regulation of cytoplasmic transport GO:1903649 4 0.068
positive regulation of gene expression GO:0010628 71 0.067
regulation of nucleocytoplasmic transport GO:0046822 2 0.067
nucleocytoplasmic transport GO:0006913 4 0.066
single organism transport GO:0044765 206 0.066
cell proliferation GO:0008283 80 0.065
specification of symmetry GO:0009799 204 0.065
regulation of macromolecule biosynthetic process GO:0010556 225 0.065
Fly
spliceosomal snrnp assembly GO:0000387 2 0.064
cellular macromolecule metabolic process GO:0044260 391 0.063
maintenance of location GO:0051235 4 0.063
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.063
Fly
protein import into nucleus GO:0006606 3 0.062
embryonic organ development GO:0048568 381 0.062
neuron development GO:0048666 262 0.062
negative regulation of multicellular organismal process GO:0051241 69 0.062
mitotic dna integrity checkpoint GO:0044774 4 0.061
eye development GO:0001654 277 0.060
embryonic organ morphogenesis GO:0048562 274 0.059
cell part morphogenesis GO:0032990 246 0.059
positive regulation of cellular metabolic process GO:0031325 94 0.058
organic substance biosynthetic process GO:1901576 289 0.058
Fly
small molecule metabolic process GO:0044281 77 0.057
mrna transport GO:0051028 2 0.057
apoptotic process GO:0006915 116 0.057
cellular component assembly GO:0022607 170 0.056
regulation of multicellular organismal development GO:2000026 223 0.056
regeneration GO:0031099 91 0.056
cellular carbohydrate metabolic process GO:0044262 4 0.055
regulation of protein catabolic process GO:0042176 1 0.055
regulation of signaling GO:0023051 235 0.055
cellular component biogenesis GO:0044085 178 0.055
regulation of transcription dna templated GO:0006355 213 0.054
Fly
brain development GO:0007420 293 0.054
positive regulation of rna metabolic process GO:0051254 59 0.053
regulation of cellular component organization GO:0051128 86 0.052
liver development GO:0001889 96 0.052
negative regulation of mitosis GO:0045839 3 0.052
digestive tract development GO:0048565 265 0.051
tube morphogenesis GO:0035239 349 0.051
regulation of macromolecule metabolic process GO:0060255 317 0.050
Fly
heart morphogenesis GO:0003007 156 0.050
neuron differentiation GO:0030182 353 0.049
biosynthetic process GO:0009058 294 0.049
Fly
vasculature development GO:0001944 278 0.049
regulation of multicellular organismal process GO:0051239 277 0.049
positive regulation of biosynthetic process GO:0009891 68 0.048
regulation of programmed cell death GO:0043067 101 0.048
cell death GO:0008219 121 0.047
negative regulation of cell cycle GO:0045786 14 0.047
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.047
response to chemical GO:0042221 320 0.047
muscle organ development GO:0007517 101 0.046
embryonic digestive tract morphogenesis GO:0048557 3 0.045
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.045
cell morphogenesis involved in differentiation GO:0000904 195 0.045
microtubule based process GO:0007017 60 0.045
positive regulation of rna biosynthetic process GO:1902680 57 0.045
regulation of signal transduction GO:0009966 225 0.044
double strand break repair GO:0006302 3 0.044
eye morphogenesis GO:0048592 144 0.044
cellular response to extracellular stimulus GO:0031668 2 0.043
organonitrogen compound metabolic process GO:1901564 74 0.043
regulation of protein transport GO:0051223 3 0.043
protein localization to nucleus GO:0034504 3 0.042
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.042
transcription from rna polymerase ii promoter GO:0006366 80 0.042
negative regulation of cell death GO:0060548 60 0.041
recombinational repair GO:0000725 1 0.041
regulation of gene expression GO:0010468 265 0.041
Fly
cell cycle g1 s phase transition GO:0044843 1 0.040
death GO:0016265 121 0.040
nucleoside monophosphate catabolic process GO:0009125 4 0.039
meiotic cell cycle process GO:1903046 3 0.039
regulation of nuclear division GO:0051783 9 0.038
protein import GO:0017038 3 0.037
amine metabolic process GO:0009308 2 0.037
regulation of gene expression epigenetic GO:0040029 11 0.036
response to organic substance GO:0010033 153 0.036
intracellular transport GO:0046907 32 0.036
organic acid metabolic process GO:0006082 31 0.036
oxoacid metabolic process GO:0043436 31 0.035
blood vessel development GO:0001568 246 0.035
regulation of cell death GO:0010941 103 0.035
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.035
adult behavior GO:0030534 2 0.034
nuclear division GO:0000280 23 0.034
negative regulation of developmental process GO:0051093 65 0.034
cellular macromolecule biosynthetic process GO:0034645 224 0.033
Fly
developmental growth GO:0048589 166 0.033
protein alkylation GO:0008213 13 0.033
chromosome organization GO:0051276 31 0.032
proteasomal protein catabolic process GO:0010498 2 0.032
regulation of response to stimulus GO:0048583 269 0.032
regulation of intracellular protein transport GO:0033157 3 0.032
neuron projection morphogenesis GO:0048812 161 0.031
cellular component morphogenesis GO:0032989 336 0.031
nucleic acid transport GO:0050657 2 0.031
response to abiotic stimulus GO:0009628 122 0.031
protein targeting to nucleus GO:0044744 3 0.031
regulation of cell communication GO:0010646 232 0.030
hatching GO:0035188 4 0.030
regulation of meiotic cell cycle GO:0051445 1 0.030
single organism nuclear import GO:1902593 3 0.030
positive regulation of nucleic acid templated transcription GO:1903508 57 0.030
multi organism reproductive process GO:0044703 36 0.030
Worm
meiosis i GO:0007127 1 0.030
system process GO:0003008 185 0.030
organism emergence from protective structure GO:0071684 4 0.029
sensory organ morphogenesis GO:0090596 200 0.029
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.029
i kappab kinase nf kappab signaling GO:0007249 4 0.029
regulation of apoptotic process GO:0042981 98 0.029
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.029
cellular response to external stimulus GO:0071496 2 0.029
regulation of cell cycle process GO:0010564 20 0.028
cognition GO:0050890 1 0.028
positive regulation of response to stimulus GO:0048584 80 0.028
positive regulation of cell cycle GO:0045787 3 0.028
establishment of localization in cell GO:0051649 77 0.028
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.028
phosphorus metabolic process GO:0006793 109 0.028
cell cycle process GO:0022402 53 0.027
negative regulation of cell differentiation GO:0045596 46 0.027
phosphate containing compound metabolic process GO:0006796 108 0.027
g1 s transition of mitotic cell cycle GO:0000082 1 0.026
regulation of intracellular signal transduction GO:1902531 57 0.026
regulation of binding GO:0051098 3 0.026
regulation of cellular biosynthetic process GO:0031326 245 0.026
Fly
regulation of rna biosynthetic process GO:2001141 213 0.026
Fly
digestive tract morphogenesis GO:0048546 231 0.026
positive regulation of chromatin modification GO:1903310 1 0.026
circulatory system process GO:0003013 87 0.026
single organism intracellular transport GO:1902582 25 0.026
angiogenesis GO:0001525 158 0.026
carboxylic acid metabolic process GO:0019752 22 0.025
response to heat GO:0009408 6 0.025
regulation of biosynthetic process GO:0009889 250 0.024
Fly
protein complex subunit organization GO:0071822 46 0.024
cellular response to stress GO:0033554 62 0.024
pore complex assembly GO:0046931 2 0.024
negative regulation of intracellular transport GO:0032387 3 0.024
cytoskeleton dependent cytokinesis GO:0061640 3 0.024
regulation of cell division GO:0051302 12 0.024
cellular response to chemical stimulus GO:0070887 157 0.024
embryonic heart tube morphogenesis GO:0003143 108 0.024
embryonic digestive tract development GO:0048566 4 0.024
multi organism cellular process GO:0044764 2 0.024
positive regulation of signaling GO:0023056 56 0.023
cellular catabolic process GO:0044248 27 0.023
non recombinational repair GO:0000726 2 0.023
mitotic cell cycle process GO:1903047 48 0.023
regulation of multicellular organism growth GO:0040014 4 0.023
cellular amine metabolic process GO:0044106 2 0.023
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.023
negative regulation of apoptotic process GO:0043066 55 0.023
cellular protein localization GO:0034613 20 0.022
definitive hemopoiesis GO:0060216 18 0.022
neuron projection development GO:0031175 180 0.022
negative regulation of signal transduction GO:0009968 94 0.022
transcription dna templated GO:0006351 181 0.022
Fly
rna export from nucleus GO:0006405 1 0.022
regulation of response to stress GO:0080134 36 0.022
macromolecule modification GO:0043412 111 0.022
positive regulation of transcription dna templated GO:0045893 57 0.021
cell division GO:0051301 20 0.021
mitotic cell cycle phase transition GO:0044772 9 0.021
multicellular organism growth GO:0035264 4 0.021
microtubule cytoskeleton organization GO:0000226 33 0.021
meiotic chromosome segregation GO:0045132 3 0.021
positive regulation of metabolic process GO:0009893 108 0.021
myeloid cell differentiation GO:0030099 86 0.021
homeostatic process GO:0042592 142 0.021
positive regulation of cellular biosynthetic process GO:0031328 68 0.021
positive regulation of mrna splicing via spliceosome GO:0048026 1 0.021
rna transport GO:0050658 2 0.021
dna metabolic process GO:0006259 27 0.021
negative regulation of mitotic cell cycle GO:0045930 11 0.020
establishment of rna localization GO:0051236 3 0.020
single organism reproductive process GO:0044702 40 0.020
Worm
ribonucleoside monophosphate catabolic process GO:0009158 4 0.020
cellular biosynthetic process GO:0044249 286 0.020
Fly
chemosensory behavior GO:0007635 1 0.020
cellular response to organic substance GO:0071310 105 0.020
regulation of glial cell differentiation GO:0045685 4 0.020
protein complex biogenesis GO:0070271 30 0.020
cytoskeleton organization GO:0007010 96 0.020
regulation of dna recombination GO:0000018 2 0.020
organic substance transport GO:0071702 58 0.020
cellular amino acid metabolic process GO:0006520 7 0.019
macromolecule localization GO:0033036 54 0.019
cell projection morphogenesis GO:0048858 244 0.019
atp catabolic process GO:0006200 4 0.019
negative regulation of response to stimulus GO:0048585 104 0.019
macromolecular complex subunit organization GO:0043933 74 0.019
gland development GO:0048732 143 0.019
mitotic g2 dna damage checkpoint GO:0007095 3 0.019
regulation of cellular amine metabolic process GO:0033238 0 0.019
cellular protein catabolic process GO:0044257 4 0.019
cell cycle checkpoint GO:0000075 7 0.018
muscle structure development GO:0061061 196 0.018
protein polyubiquitination GO:0000209 4 0.018
negative regulation of protein transport GO:0051224 3 0.018
purine nucleoside monophosphate catabolic process GO:0009128 4 0.018
positive regulation of dna metabolic process GO:0051054 1 0.018
enzyme linked receptor protein signaling pathway GO:0007167 106 0.018
dorsal ventral pattern formation GO:0009953 125 0.018
cell morphogenesis GO:0000902 289 0.018
double strand break repair via nonhomologous end joining GO:0006303 1 0.018
cell growth GO:0016049 57 0.018
peptidyl lysine acetylation GO:0018394 2 0.018
nuclear import GO:0051170 3 0.018
hepaticobiliary system development GO:0061008 98 0.017
negative regulation of cytoplasmic transport GO:1903650 2 0.017
multicellular organismal reproductive process GO:0048609 35 0.017
Worm
negative regulation of macromolecule metabolic process GO:0010605 76 0.017
positive regulation of mrna processing GO:0050685 1 0.017
developmental process involved in reproduction GO:0003006 27 0.017
Worm
positive regulation of signal transduction GO:0009967 56 0.017
regulation of primary metabolic process GO:0080090 311 0.017
Fly
embryonic heart tube development GO:0035050 133 0.017
regulation of embryonic development GO:0045995 47 0.017
negative regulation of nuclear division GO:0051784 3 0.017
camera type eye development GO:0043010 222 0.016
lipid storage GO:0019915 1 0.016
negative regulation of ras protein signal transduction GO:0046580 1 0.016
dna integrity checkpoint GO:0031570 6 0.016
microtubule organizing center organization GO:0031023 1 0.016
regulation of biological quality GO:0065008 263 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
macromolecular complex assembly GO:0065003 35 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.016
regulation of nervous system development GO:0051960 90 0.016
regulation of protein complex assembly GO:0043254 3 0.015
cellular ketone metabolic process GO:0042180 11 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
single organism biosynthetic process GO:0044711 71 0.015
ras protein signal transduction GO:0007265 7 0.015
regulation of organelle organization GO:0033043 29 0.015
blood vessel morphogenesis GO:0048514 216 0.015
cell aging GO:0007569 2 0.014
positive regulation of catabolic process GO:0009896 4 0.014
heart looping GO:0001947 94 0.014
mitotic g2 m transition checkpoint GO:0044818 3 0.014
positive regulation of glial cell differentiation GO:0045687 1 0.014
histone modification GO:0016570 20 0.014
positive regulation of gliogenesis GO:0014015 2 0.014
wound healing GO:0042060 90 0.014
positive regulation of rna splicing GO:0033120 1 0.014
positive regulation of mrna metabolic process GO:1903313 2 0.014
mrna metabolic process GO:0016071 20 0.014
negative regulation of programmed cell death GO:0043069 58 0.014
nucleobase containing compound transport GO:0015931 2 0.014
cell cycle g2 m phase transition GO:0044839 4 0.014
axonogenesis GO:0007409 152 0.014
response to lipid GO:0033993 60 0.014
negative regulation of gene expression GO:0010629 65 0.014
regulation of protein targeting GO:1903533 2 0.013
multi organism process GO:0051704 134 0.013
Worm
sexual reproduction GO:0019953 36 0.013
Worm
regulation of mitotic cell cycle phase transition GO:1901990 8 0.013
nuclear export GO:0051168 1 0.013
centrosome organization GO:0051297 1 0.013
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.013
negative regulation of intracellular signal transduction GO:1902532 22 0.013
protein localization GO:0008104 40 0.013
protein complex localization GO:0031503 1 0.013
histone methylation GO:0016571 13 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.013
spliceosomal tri snrnp complex assembly GO:0000244 1 0.013
small gtpase mediated signal transduction GO:0007264 8 0.013
spermatid development GO:0007286 2 0.013
negative regulation of biosynthetic process GO:0009890 55 0.013
protein acetylation GO:0006473 2 0.013
behavior GO:0007610 74 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
negative regulation of response to dna damage stimulus GO:2001021 3 0.012
mitotic cytokinesis GO:0000281 3 0.012
negative regulation of rna metabolic process GO:0051253 48 0.012
negative regulation of cell cycle process GO:0010948 9 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.012
reproduction GO:0000003 40 0.012
Worm
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
camera type eye morphogenesis GO:0048593 108 0.012
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.012
regulation of cell development GO:0060284 100 0.012
cytokinesis GO:0000910 3 0.012
catabolic process GO:0009056 32 0.012
phagocytosis GO:0006909 3 0.012
positive regulation of cytokine production GO:0001819 2 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
oxidation reduction process GO:0055114 41 0.012
neuron neuron synaptic transmission GO:0007270 1 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.012
response to hormone GO:0009725 48 0.012
regulation of histone methylation GO:0031060 3 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.012
protein complex assembly GO:0006461 30 0.012
epithelial tube morphogenesis GO:0060562 148 0.012
positive regulation of transport GO:0051050 2 0.012
modification of morphology or physiology of other organism GO:0035821 4 0.012
spindle assembly GO:0051225 2 0.012
regulation of cell cycle phase transition GO:1901987 8 0.012
glucose homeostasis GO:0042593 1 0.011
response to monosaccharide GO:0034284 3 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
negative regulation of chromosome organization GO:2001251 1 0.011
positive regulation of ras protein signal transduction GO:0046579 1 0.011
negative regulation of nucleic acid templated transcription GO:1903507 45 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.011
negative regulation of rna biosynthetic process GO:1902679 45 0.011
negative regulation of intracellular protein transport GO:0090317 3 0.011
meiotic cell cycle GO:0051321 5 0.011
internal peptidyl lysine acetylation GO:0018393 2 0.011
central nervous system neuron differentiation GO:0021953 74 0.010
mitotic cell cycle checkpoint GO:0007093 5 0.010
response to glucose GO:0009749 3 0.010
growth GO:0040007 174 0.010
chemotaxis GO:0006935 104 0.010
double strand break repair via homologous recombination GO:0000724 1 0.010
cellular component disassembly GO:0022411 1 0.010
cell surface receptor signaling pathway GO:0007166 325 0.010
dna damage checkpoint GO:0000077 6 0.010
mrna export from nucleus GO:0006406 1 0.010

sae1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.024
disease of cellular proliferation DOID:14566 0 0.024
organ system cancer DOID:0050686 0 0.018