Danio rerio

0 known processes

scn4ab

sodium channel, voltage-gated, type IV, alpha, b

(Aliases: Nav1.4b)

scn4ab biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
muscle structure development GO:0061061 196 0.778
transmembrane transport GO:0055085 120 0.513
Zebrafish Mouse
muscle cell development GO:0055001 115 0.500
ion transmembrane transport GO:0034220 91 0.479
Zebrafish Mouse
cardiac conduction GO:0061337 3 0.348
central nervous system development GO:0007417 387 0.305
embryonic organ morphogenesis GO:0048562 274 0.259
determination of bilateral symmetry GO:0009855 204 0.240
muscle tissue development GO:0060537 110 0.234
sodium ion transmembrane transport GO:0035725 21 0.224
Zebrafish Mouse
striated muscle tissue development GO:0014706 110 0.209
heart development GO:0007507 313 0.200
muscle cell differentiation GO:0042692 139 0.199
multicellular organismal signaling GO:0035637 22 0.173
Zebrafish
specification of symmetry GO:0009799 204 0.159
heart morphogenesis GO:0003007 156 0.148
striated muscle cell differentiation GO:0051146 129 0.142
myofibril assembly GO:0030239 48 0.136
cellular component assembly GO:0022607 170 0.125
cell projection morphogenesis GO:0048858 244 0.122
Zebrafish
regulation of cell development GO:0060284 100 0.117
transmission of nerve impulse GO:0019226 19 0.110
Zebrafish
regulation of signaling GO:0023051 235 0.108
skeletal muscle organ development GO:0060538 78 0.107
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.107
regulation of neurogenesis GO:0050767 87 0.106
striated muscle cell development GO:0055002 108 0.099
muscle organ development GO:0007517 101 0.098
determination of left right symmetry GO:0007368 179 0.094
cell part morphogenesis GO:0032990 246 0.093
Zebrafish
regulation of multicellular organismal process GO:0051239 277 0.092
regulation of dendrite development GO:0050773 3 0.092
muscle fiber development GO:0048747 52 0.088
regulation of biological quality GO:0065008 263 0.087
Zebrafish
locomotion GO:0040011 313 0.087
Zebrafish
larval development GO:0002164 2 0.086
cellular aldehyde metabolic process GO:0006081 4 0.085
membrane repolarization GO:0086009 2 0.084
positive regulation of transport GO:0051050 2 0.083
adult behavior GO:0030534 2 0.080
cellular component biogenesis GO:0044085 178 0.077
system process GO:0003008 185 0.077
Zebrafish
negative regulation of cellular process GO:0048523 283 0.077
cardiac muscle cell differentiation GO:0055007 30 0.072
aging GO:0007568 2 0.070
transport GO:0006810 220 0.069
Zebrafish Mouse
skeletal muscle thin filament assembly GO:0030240 4 0.068
heart looping GO:0001947 94 0.068
heart process GO:0003015 71 0.066
sarcomerogenesis GO:0048769 4 0.066
inorganic ion transmembrane transport GO:0098660 57 0.062
Zebrafish Mouse
embryonic organ development GO:0048568 381 0.062
neuron projection development GO:0031175 180 0.061
Zebrafish
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.061
regulation of rna biosynthetic process GO:2001141 213 0.061
cellular amine metabolic process GO:0044106 2 0.059
regulation of synaptic plasticity GO:0048167 1 0.059
regulation of biosynthetic process GO:0009889 250 0.058
single organism organelle organization GO:1902589 199 0.057
embryonic heart tube morphogenesis GO:0003143 108 0.057
brain development GO:0007420 293 0.057
regulation of neuron projection development GO:0010975 40 0.057
cation transmembrane transport GO:0098655 65 0.056
Zebrafish Mouse
signal transduction GO:0007165 455 0.056
skeletal system development GO:0001501 181 0.055
inorganic cation transmembrane transport GO:0098662 50 0.052
Zebrafish Mouse
sensory organ development GO:0007423 393 0.052
cardiac muscle fiber development GO:0048739 3 0.052
head development GO:0060322 303 0.052
cell morphogenesis GO:0000902 289 0.051
Zebrafish
regulation of cell differentiation GO:0045595 142 0.049
morphogenesis of an epithelium GO:0002009 333 0.049
regulation of cell projection organization GO:0031344 44 0.049
purine nucleoside monophosphate catabolic process GO:0009128 4 0.047
cellular component morphogenesis GO:0032989 336 0.047
Zebrafish
oxidative phosphorylation GO:0006119 1 0.047
tube morphogenesis GO:0035239 349 0.046
stem cell proliferation GO:0072089 4 0.046
cell surface receptor signaling pathway GO:0007166 325 0.046
cellular component movement GO:0006928 335 0.046
Zebrafish
cell motility GO:0048870 244 0.046
skeletal muscle tissue development GO:0007519 67 0.045
establishment of localization GO:0051234 244 0.045
Zebrafish Mouse
macromolecule biosynthetic process GO:0009059 227 0.044
cell death in response to oxidative stress GO:0036473 2 0.044
regulation of cytokine production GO:0001817 3 0.043
positive regulation of cytokine production GO:0001819 2 0.042
skeletal muscle fiber development GO:0048741 35 0.042
response to chemical GO:0042221 320 0.042
Zebrafish
determination of heart left right asymmetry GO:0061371 117 0.041
regulation of macromolecule biosynthetic process GO:0010556 225 0.041
regulation of cellular amino acid metabolic process GO:0006521 0 0.040
biosynthetic process GO:0009058 294 0.040
regulation of skeletal muscle tissue development GO:0048641 4 0.040
muscle contraction GO:0006936 18 0.039
cellular biosynthetic process GO:0044249 286 0.038
regulation of response to stimulus GO:0048583 269 0.038
heart contraction GO:0060047 71 0.038
amine metabolic process GO:0009308 2 0.037
astrocyte differentiation GO:0048708 1 0.037
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.037
response to organic substance GO:0010033 153 0.036
defense response GO:0006952 47 0.036
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.036
single organism localization GO:1902578 225 0.036
Zebrafish Mouse
regulation of synapse organization GO:0050807 3 0.035
regulation of multicellular organismal development GO:2000026 223 0.035
response to stress GO:0006950 263 0.035
regulation of cellular amine metabolic process GO:0033238 0 0.034
response to external stimulus GO:0009605 264 0.034
Zebrafish
nucleobase containing compound biosynthetic process GO:0034654 205 0.034
cell matrix adhesion GO:0007160 4 0.033
regulation of binding GO:0051098 3 0.033
organelle assembly GO:0070925 110 0.032
cardiac muscle tissue development GO:0048738 48 0.032
peptidyl serine phosphorylation GO:0018105 1 0.032
regulation of reactive oxygen species metabolic process GO:2000377 2 0.032
central nervous system neuron development GO:0021954 29 0.032
nucleic acid templated transcription GO:0097659 181 0.032
regulation of developmental process GO:0050793 247 0.032
organonitrogen compound metabolic process GO:1901564 74 0.032
single organism metabolic process GO:0044710 217 0.031
proteasomal protein catabolic process GO:0010498 2 0.031
heterocycle metabolic process GO:0046483 290 0.031
localization of cell GO:0051674 244 0.030
regulation of protein binding GO:0043393 3 0.030
organic cyclic compound metabolic process GO:1901360 301 0.030
positive regulation of muscle tissue development GO:1901863 1 0.029
regulation of nervous system development GO:0051960 90 0.029
response to abiotic stimulus GO:0009628 122 0.029
Zebrafish
circulatory system process GO:0003013 87 0.029
oxoacid metabolic process GO:0043436 31 0.029
negative regulation of biological process GO:0048519 304 0.029
regulation of cardiac muscle contraction GO:0055117 2 0.029
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.028
positive regulation of cellular component biogenesis GO:0044089 3 0.028
female sex differentiation GO:0046660 4 0.028
estrogen metabolic process GO:0008210 2 0.028
atp catabolic process GO:0006200 4 0.028
regulation of muscle contraction GO:0006937 3 0.028
regulation of transport GO:0051049 45 0.028
Zebrafish Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.028
meiotic nuclear division GO:0007126 4 0.027
rna metabolic process GO:0016070 219 0.027
neuromuscular synaptic transmission GO:0007274 2 0.027
organic acid metabolic process GO:0006082 31 0.026
cellular amino acid metabolic process GO:0006520 7 0.026
reactive oxygen species biosynthetic process GO:1903409 1 0.026
small molecule metabolic process GO:0044281 77 0.026
regulation of anatomical structure morphogenesis GO:0022603 130 0.026
positive regulation of biological process GO:0048518 253 0.026
cell morphogenesis involved in differentiation GO:0000904 195 0.026
Zebrafish
motor neuron axon guidance GO:0008045 23 0.026
Zebrafish
transcription dna templated GO:0006351 181 0.026
embryonic heart tube development GO:0035050 133 0.025
organic substance biosynthetic process GO:1901576 289 0.025
neuron differentiation GO:0030182 353 0.025
Zebrafish
regulation of neuron differentiation GO:0045664 56 0.025
morphogenesis of an epithelial sheet GO:0002011 49 0.025
epithelial tube morphogenesis GO:0060562 148 0.024
swimming behavior GO:0036269 8 0.024
Zebrafish
regulation of cellular biosynthetic process GO:0031326 245 0.024
phagocytosis GO:0006909 3 0.024
cellular macromolecule metabolic process GO:0044260 391 0.024
g protein coupled receptor signaling pathway GO:0007186 74 0.024
trabecula morphogenesis GO:0061383 2 0.024
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.024
ion transport GO:0006811 114 0.024
Zebrafish Mouse
organelle organization GO:0006996 227 0.023
axonogenesis GO:0007409 152 0.023
Zebrafish
regulation of protein catabolic process GO:0042176 1 0.023
regulation of skeletal muscle fiber development GO:0048742 2 0.022
regulation of organelle assembly GO:1902115 4 0.022
regulation of membrane potential GO:0042391 23 0.022
Zebrafish
negative regulation of protein phosphorylation GO:0001933 4 0.022
nitrogen compound metabolic process GO:0006807 319 0.022
negative regulation of protein kinase activity GO:0006469 4 0.022
gene expression GO:0010467 252 0.021
cellular carbohydrate metabolic process GO:0044262 4 0.021
transcription from rna polymerase ii promoter GO:0006366 80 0.021
cell substrate adhesion GO:0031589 4 0.021
regulation of nitrogen compound metabolic process GO:0051171 251 0.021
female gonad development GO:0008585 4 0.021
digestive tract morphogenesis GO:0048546 231 0.021
regulation of stem cell proliferation GO:0072091 2 0.021
neuron development GO:0048666 262 0.021
Zebrafish
reactive nitrogen species metabolic process GO:2001057 0 0.021
regulation of synapse assembly GO:0051963 3 0.021
positive regulation of stem cell proliferation GO:2000648 1 0.020
cellular protein complex assembly GO:0043623 19 0.020
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.020
cellular component assembly involved in morphogenesis GO:0010927 107 0.020
atp synthesis coupled electron transport GO:0042773 1 0.020
axon development GO:0061564 166 0.020
Zebrafish
positive regulation of macromolecule metabolic process GO:0010604 93 0.020
hormone biosynthetic process GO:0042446 3 0.020
peptidyl lysine methylation GO:0018022 3 0.020
cellular response to radiation GO:0071478 4 0.020
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.019
development of primary female sexual characteristics GO:0046545 4 0.019
regulation of programmed cell death GO:0043067 101 0.019
regulation of response to oxidative stress GO:1902882 2 0.019
negative regulation of muscle tissue development GO:1901862 2 0.019
nucleobase containing compound metabolic process GO:0006139 274 0.019
carbohydrate biosynthetic process GO:0016051 1 0.019
protein metabolic process GO:0019538 183 0.018
protein stabilization GO:0050821 2 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
cardiac atrium development GO:0003230 4 0.018
cellular response to steroid hormone stimulus GO:0071383 31 0.018
inner ear development GO:0048839 126 0.018
cellular nitrogen compound biosynthetic process GO:0044271 218 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.018
developmental growth involved in morphogenesis GO:0060560 86 0.018
nucleoside monophosphate catabolic process GO:0009125 4 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.018
post golgi vesicle mediated transport GO:0006892 1 0.018
positive regulation of blood circulation GO:1903524 2 0.018
mitochondrion organization GO:0007005 4 0.018
ribonucleoside monophosphate catabolic process GO:0009158 4 0.018
blood vessel development GO:0001568 246 0.018
protein complex assembly GO:0006461 30 0.018
cellular macromolecule biosynthetic process GO:0034645 224 0.018
neuron projection guidance GO:0097485 86 0.018
Zebrafish
regulation of system process GO:0044057 40 0.018
negative regulation of catalytic activity GO:0043086 21 0.018
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.018
negative regulation of kinase activity GO:0033673 4 0.017
regulation of receptor activity GO:0010469 2 0.017
ubiquitin dependent protein catabolic process GO:0006511 3 0.017
regulation of cell communication GO:0010646 232 0.017
neuronal action potential GO:0019228 18 0.017
Zebrafish
positive regulation of muscle organ development GO:0048636 1 0.017
cytokinesis GO:0000910 3 0.017
cellular nitrogen compound metabolic process GO:0034641 290 0.017
regulation of blood vessel size GO:0050880 2 0.017
regulation of membrane repolarization GO:0060306 1 0.017
positive regulation of cell projection organization GO:0031346 9 0.017
blood circulation GO:0008015 87 0.017
positive regulation of multicellular organismal process GO:0051240 52 0.017
developmental growth GO:0048589 166 0.017
cardiac muscle myosin thick filament assembly GO:0071690 1 0.016
regulation of transmembrane transporter activity GO:0022898 2 0.016
regulation of protein transport GO:0051223 3 0.016
bmp signaling pathway GO:0030509 52 0.016
neuroblast proliferation GO:0007405 2 0.016
nitric oxide biosynthetic process GO:0006809 2 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
cellular aromatic compound metabolic process GO:0006725 295 0.016
mitotic dna damage checkpoint GO:0044773 4 0.016
regulation of gene expression GO:0010468 265 0.016
protein complex biogenesis GO:0070271 30 0.016
cell projection organization GO:0030030 284 0.015
Zebrafish
phosphorylation GO:0016310 69 0.015
embryo development ending in birth or egg hatching GO:0009792 271 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
rna biosynthetic process GO:0032774 181 0.015
cellular response to organic substance GO:0071310 105 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
regulation of dendrite morphogenesis GO:0048814 3 0.015
central nervous system neuron axonogenesis GO:0021955 18 0.015
chemotaxis GO:0006935 104 0.015
Zebrafish
blood vessel morphogenesis GO:0048514 216 0.015
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.015
positive regulation of heart contraction GO:0045823 2 0.015
negative regulation of programmed cell death GO:0043069 58 0.015
regulation of myotube differentiation GO:0010830 2 0.015
cellular protein modification process GO:0006464 100 0.015
protein dephosphorylation GO:0006470 3 0.015
cell migration GO:0016477 237 0.015
negative regulation of multicellular organismal process GO:0051241 69 0.015
aromatic compound biosynthetic process GO:0019438 217 0.015
notochord development GO:0030903 54 0.015
multicellular organismal response to stress GO:0033555 2 0.015
immune system process GO:0002376 241 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
cardiac muscle cell contraction GO:0086003 1 0.015
peptide metabolic process GO:0006518 1 0.015
regulation of inflammatory response GO:0050727 2 0.015
response to carbohydrate GO:0009743 3 0.015
cation transport GO:0006812 81 0.014
Zebrafish Mouse
developmental cell growth GO:0048588 52 0.014
actomyosin structure organization GO:0031032 53 0.014
gastrulation GO:0007369 208 0.014
positive regulation of neuron projection development GO:0010976 9 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.014
Zebrafish
circadian sleep wake cycle sleep GO:0050802 1 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
regulation of nucleoside metabolic process GO:0009118 2 0.014
gastrulation with mouth forming second GO:0001702 44 0.014
chordate embryonic development GO:0043009 271 0.014
neural crest formation GO:0014029 14 0.014
heterocycle biosynthetic process GO:0018130 215 0.014
regulation of rna metabolic process GO:0051252 224 0.014
apoptotic process GO:0006915 116 0.014
regulation of cell motility GO:2000145 46 0.013
mesenchymal cell differentiation GO:0048762 87 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
regulation of metabolic process GO:0019222 359 0.013
regulation of dna replication GO:0006275 3 0.013
endocardial cushion formation GO:0003272 2 0.013
regulation of organ growth GO:0046620 3 0.013
cellular ketone metabolic process GO:0042180 11 0.013
vasculature development GO:0001944 278 0.013
nitric oxide metabolic process GO:0046209 2 0.013
regulation of sarcomere organization GO:0060297 2 0.013
cellular response to endogenous stimulus GO:0071495 68 0.013
regulation of behavior GO:0050795 24 0.013
hormone metabolic process GO:0042445 19 0.013
histone h3 k4 methylation GO:0051568 2 0.012
monovalent inorganic cation transport GO:0015672 42 0.012
Zebrafish Mouse
response to monosaccharide GO:0034284 3 0.012
cardiocyte differentiation GO:0035051 44 0.012
response to vitamin b3 GO:0033552 2 0.012
larval behavior GO:0030537 5 0.012
Zebrafish
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.012
regulation of cellular component organization GO:0051128 86 0.012
response to uv GO:0009411 3 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.012
regulation of cellular metabolic process GO:0031323 320 0.012
dopamine metabolic process GO:0042417 2 0.012
regulation of protein complex assembly GO:0043254 3 0.012
mesenchyme development GO:0060485 127 0.012
regulation of oxidative stress induced cell death GO:1903201 2 0.012
autophagy GO:0006914 4 0.012
embryonic limb morphogenesis GO:0030326 2 0.012
iron ion homeostasis GO:0055072 4 0.012
cardiac myofibril assembly GO:0055003 9 0.012
alcohol biosynthetic process GO:0046165 2 0.012
histone phosphorylation GO:0016572 2 0.012
protein homooligomerization GO:0051260 3 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
eye development GO:0001654 277 0.012
cellular response to hormone stimulus GO:0032870 39 0.012
defense response to other organism GO:0098542 33 0.012
positive regulation of nucleic acid templated transcription GO:1903508 57 0.012
negative regulation of striated muscle tissue development GO:0045843 2 0.012
negative regulation of bmp signaling pathway GO:0030514 13 0.012
actin filament based movement GO:0030048 1 0.012
cell substrate junction assembly GO:0007044 2 0.012
anterior posterior pattern specification GO:0009952 152 0.012
sex determination GO:0007530 1 0.012
protein modification process GO:0036211 100 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
neurotransmitter transport GO:0006836 2 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
kidney development GO:0001822 92 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
cellular protein catabolic process GO:0044257 4 0.011
regulation of apoptotic process GO:0042981 98 0.011
regulation of transmembrane transport GO:0034762 18 0.011
Zebrafish Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
peptidyl serine modification GO:0018209 2 0.011
regulation of ion transport GO:0043269 22 0.011
Zebrafish Mouse
negative regulation of cytokine production GO:0001818 1 0.011
regulation of bmp signaling pathway GO:0030510 39 0.011
cytoskeleton organization GO:0007010 96 0.011
positive regulation of skeletal muscle tissue development GO:0048643 1 0.011
programmed cell death GO:0012501 119 0.011
neuron projection morphogenesis GO:0048812 161 0.011
Zebrafish
cell cell signaling GO:0007267 52 0.011
organism emergence from protective structure GO:0071684 4 0.011
lipid homeostasis GO:0055088 3 0.011
response to hydrogen peroxide GO:0042542 3 0.011
locomotory behavior GO:0007626 34 0.011
Zebrafish
protein acetylation GO:0006473 2 0.011
rna localization GO:0006403 4 0.011
regulation of localization GO:0032879 104 0.011
Zebrafish Mouse
regulation of primary metabolic process GO:0080090 311 0.011
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
epithelial to mesenchymal transition GO:0001837 21 0.011
growth GO:0040007 174 0.011
positive regulation of cell cycle GO:0045787 3 0.011
neural crest cell differentiation GO:0014033 72 0.011
regulation of axonogenesis GO:0050770 32 0.011
detection of mechanical stimulus involved in sensory perception of touch GO:0050976 2 0.011
myotube differentiation GO:0014902 45 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
negative regulation of cell death GO:0060548 60 0.011
regulation of signal transduction GO:0009966 225 0.010
myeloid cell homeostasis GO:0002262 56 0.010
neuron projection extension GO:1990138 45 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.010
regulation of reproductive process GO:2000241 4 0.010
nucleic acid metabolic process GO:0090304 244 0.010
specification of axis polarity GO:0065001 4 0.010
cellular response to estradiol stimulus GO:0071392 1 0.010
axis specification GO:0009798 43 0.010
cell migration involved in gastrulation GO:0042074 79 0.010
establishment of protein localization to organelle GO:0072594 4 0.010
regeneration GO:0031099 91 0.010

scn4ab disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
heart disease DOID:114 0 0.077
cardiomyopathy DOID:0050700 0 0.077
disease of anatomical entity DOID:7 0 0.077
muscular disease DOID:0080000 0 0.077
muscle tissue disease DOID:66 0 0.077
cardiovascular system disease DOID:1287 0 0.077
myopathy DOID:423 0 0.077
musculoskeletal system disease DOID:17 0 0.077
intrinsic cardiomyopathy DOID:0060036 0 0.049
nervous system disease DOID:863 0 0.029
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011