Danio rerio

18 known processes

sema3e

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

(Aliases: fj37c11,wu:fj37c11,si:ch211-120m13.2)

sema3e biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
axonal defasciculation GO:0007414 2 0.359
regulation of macromolecule biosynthetic process GO:0010556 225 0.294
neuron development GO:0048666 262 0.292
regulation of rna metabolic process GO:0051252 224 0.244
positive regulation of biological process GO:0048518 253 0.239
regulation of cellular metabolic process GO:0031323 320 0.232
morphogenesis of a branching structure GO:0001763 21 0.226
Mouse
regulation of gene expression GO:0010468 265 0.224
mesenchyme development GO:0060485 127 0.223
Zebrafish
facial nerve morphogenesis GO:0021610 1 0.222
tube morphogenesis GO:0035239 349 0.216
Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.214
specification of symmetry GO:0009799 204 0.211
cell morphogenesis GO:0000902 289 0.207
Mouse
locomotion GO:0040011 313 0.202
Zebrafish
cellular macromolecule metabolic process GO:0044260 391 0.195
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.171
sympathetic nervous system development GO:0048485 3 0.170
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.165
positive regulation of cellular process GO:0048522 201 0.158
vasculature development GO:0001944 278 0.156
organic cyclic compound biosynthetic process GO:1901362 223 0.155
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.150
regulation of primary metabolic process GO:0080090 311 0.150
negative regulation of cellular process GO:0048523 283 0.143
Mouse
rna metabolic process GO:0016070 219 0.141
positive regulation of signal transduction GO:0009967 56 0.138
embryo development ending in birth or egg hatching GO:0009792 271 0.136
biosynthetic process GO:0009058 294 0.131
cellular aromatic compound metabolic process GO:0006725 295 0.129
sensory organ development GO:0007423 393 0.126
sprouting angiogenesis GO:0002040 53 0.124
embryonic organ development GO:0048568 381 0.123
retina development in camera type eye GO:0060041 146 0.119
cell projection organization GO:0030030 284 0.113
negative regulation of biological process GO:0048519 304 0.112
Mouse
localization of cell GO:0051674 244 0.111
Zebrafish
heterocycle metabolic process GO:0046483 290 0.110
regulation of multicellular organismal development GO:2000026 223 0.106
Mouse
nucleic acid templated transcription GO:0097659 181 0.101
axonogenesis GO:0007409 152 0.099
gene expression GO:0010467 252 0.096
developmental growth GO:0048589 166 0.092
response to chemical GO:0042221 320 0.092
regulation of developmental process GO:0050793 247 0.092
Mouse
regulation of collateral sprouting in absence of injury GO:0048696 4 0.091
generation of neurons GO:0048699 385 0.089
macromolecule biosynthetic process GO:0009059 227 0.089
cell motility GO:0048870 244 0.088
Zebrafish
cellular nitrogen compound biosynthetic process GO:0044271 218 0.086
regulation of biosynthetic process GO:0009889 250 0.085
chemotaxis GO:0006935 104 0.085
morphogenesis of an epithelium GO:0002009 333 0.084
Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.084
digestive tract development GO:0048565 265 0.082
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.082
aromatic compound biosynthetic process GO:0019438 217 0.081
cellular component movement GO:0006928 335 0.079
Zebrafish
cell projection morphogenesis GO:0048858 244 0.079
organic cyclic compound metabolic process GO:1901360 301 0.078
developmental growth involved in morphogenesis GO:0060560 86 0.077
synaptic growth at neuromuscular junction GO:0051124 2 0.076
autonomic nervous system development GO:0048483 19 0.076
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.075
blood vessel morphogenesis GO:0048514 216 0.075
cell part morphogenesis GO:0032990 246 0.073
cell morphogenesis involved in differentiation GO:0000904 195 0.073
negative regulation of chemotaxis GO:0050922 4 0.073
nucleic acid metabolic process GO:0090304 244 0.073
neuron projection development GO:0031175 180 0.072
regulation of transcription dna templated GO:0006355 213 0.071
regulation of axon guidance GO:1902667 8 0.069
regulation of synapse assembly GO:0051963 3 0.069
chordate embryonic development GO:0043009 271 0.068
regulation of response to stimulus GO:0048583 269 0.068
nitrogen compound metabolic process GO:0006807 319 0.067
outflow tract morphogenesis GO:0003151 1 0.065
cellular nitrogen compound metabolic process GO:0034641 290 0.065
neuron projection morphogenesis GO:0048812 161 0.063
negative chemotaxis GO:0050919 1 0.062
cellular biosynthetic process GO:0044249 286 0.062
regulation of synapse organization GO:0050807 3 0.061
digestive system development GO:0055123 289 0.061
positive regulation of programmed cell death GO:0043068 29 0.060
determination of dorsal ventral asymmetry GO:0048262 34 0.058
camera type eye development GO:0043010 222 0.058
negative regulation of axon guidance GO:1902668 1 0.057
cartilage development GO:0051216 96 0.057
positive regulation of response to stimulus GO:0048584 80 0.057
rna biosynthetic process GO:0032774 181 0.057
positive regulation of apoptotic signaling pathway GO:2001235 1 0.056
regulation of multicellular organismal process GO:0051239 277 0.056
Mouse
extrinsic apoptotic signaling pathway GO:0097191 3 0.055
gastrulation GO:0007369 208 0.055
taxis GO:0042330 109 0.055
transcription dna templated GO:0006351 181 0.053
regulation of macromolecule metabolic process GO:0060255 317 0.053
growth GO:0040007 174 0.050
regulation of localization GO:0032879 104 0.050
regulation of axon extension involved in axon guidance GO:0048841 6 0.050
positive regulation of epithelial cell proliferation GO:0050679 1 0.049
regulation of cellular component movement GO:0051270 55 0.048
facial nerve development GO:0021561 3 0.048
cellular macromolecule biosynthetic process GO:0034645 224 0.048
regulation of bmp signaling pathway GO:0030510 39 0.047
ear development GO:0043583 127 0.044
regulation of metabolic process GO:0019222 359 0.044
positive regulation of developmental process GO:0051094 50 0.043
neuron projection extension involved in neuron projection guidance GO:1902284 10 0.043
regulation of cellular biosynthetic process GO:0031326 245 0.043
regulation of nervous system development GO:0051960 90 0.043
organic substance biosynthetic process GO:1901576 289 0.043
response to external stimulus GO:0009605 264 0.042
enzyme linked receptor protein signaling pathway GO:0007167 106 0.042
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.041
collateral sprouting in absence of injury GO:0048669 4 0.041
cation transmembrane transport GO:0098655 65 0.041
organelle organization GO:0006996 227 0.041
Mouse
cell migration GO:0016477 237 0.040
Zebrafish
neuron differentiation GO:0030182 353 0.040
regulation of rna biosynthetic process GO:2001141 213 0.039
nucleobase containing compound biosynthetic process GO:0034654 205 0.039
positive regulation of cell communication GO:0010647 56 0.039
axon guidance GO:0007411 86 0.038
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.037
cell differentiation in spinal cord GO:0021515 40 0.036
regionalization GO:0003002 274 0.036
blood vessel development GO:0001568 246 0.036
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.036
determination of bilateral symmetry GO:0009855 204 0.035
single organism organelle organization GO:1902589 199 0.035
Mouse
eye morphogenesis GO:0048592 144 0.034
appendage development GO:0048736 80 0.034
neuron projection extension GO:1990138 45 0.034
neuroblast proliferation GO:0007405 2 0.034
axon development GO:0061564 166 0.032
epithelial tube morphogenesis GO:0060562 148 0.032
Mouse
behavior GO:0007610 74 0.032
embryonic skeletal system development GO:0048706 97 0.032
regulation of cell development GO:0060284 100 0.032
dorsal ventral pattern formation GO:0009953 125 0.032
heterocycle biosynthetic process GO:0018130 215 0.032
tissue remodeling GO:0048771 4 0.031
motor neuron axon guidance GO:0008045 23 0.031
protein localization to nucleus GO:0034504 3 0.031
regulation of programmed cell death GO:0043067 101 0.031
aging GO:0007568 2 0.031
regulation of epithelial cell proliferation GO:0050678 3 0.030
diencephalon development GO:0021536 58 0.029
stem cell differentiation GO:0048863 117 0.029
Zebrafish
regulation of protein depolymerization GO:1901879 1 0.029
cell substrate adhesion GO:0031589 4 0.029
Mouse
urogenital system development GO:0001655 97 0.029
trigeminal nerve development GO:0021559 3 0.029
regulation of ion transmembrane transporter activity GO:0032412 2 0.029
eye development GO:0001654 277 0.028
regulation of signal transduction GO:0009966 225 0.028
signal transduction in absence of ligand GO:0038034 1 0.028
brain development GO:0007420 293 0.028
stem cell development GO:0048864 82 0.028
Zebrafish
regulation of multicellular organism growth GO:0040014 4 0.028
organic acid catabolic process GO:0016054 3 0.028
cell surface receptor signaling pathway GO:0007166 325 0.028
Mouse
nucleoside phosphate biosynthetic process GO:1901293 21 0.028
regulation of nucleotide biosynthetic process GO:0030808 15 0.027
neuron projection guidance GO:0097485 86 0.027
cell death GO:0008219 121 0.027
regulation of chemotaxis GO:0050920 18 0.027
microtubule depolymerization GO:0007019 1 0.027
cell fate commitment GO:0045165 99 0.027
head development GO:0060322 303 0.027
apoptotic process GO:0006915 116 0.027
somite development GO:0061053 96 0.026
inorganic ion transmembrane transport GO:0098660 57 0.026
cellular component morphogenesis GO:0032989 336 0.026
Mouse
morphogenesis of a branching epithelium GO:0061138 16 0.026
Mouse
anatomical structure arrangement GO:0048532 2 0.025
nucleobase containing compound metabolic process GO:0006139 274 0.025
hair cell differentiation GO:0035315 32 0.025
protein homooligomerization GO:0051260 3 0.025
developmental cell growth GO:0048588 52 0.024
transport GO:0006810 220 0.024
monovalent inorganic cation transport GO:0015672 42 0.024
transcription from rna polymerase ii promoter GO:0006366 80 0.024
signal transduction GO:0007165 455 0.023
Mouse
axon midline choice point recognition GO:0016199 4 0.023
programmed cell death GO:0012501 119 0.023
synapse organization GO:0050808 21 0.023
Mouse
central nervous system development GO:0007417 387 0.023
transmembrane transport GO:0055085 120 0.023
guanosine containing compound metabolic process GO:1901068 4 0.022
multicellular organism growth GO:0035264 4 0.022
protein depolymerization GO:0051261 1 0.022
neural crest cell differentiation GO:0014033 72 0.022
Zebrafish
regulation of cell communication GO:0010646 232 0.021
cellular component assembly GO:0022607 170 0.021
cellular component disassembly GO:0022411 1 0.021
negative regulation of axon extension GO:0030517 7 0.021
regulation of transporter activity GO:0032409 2 0.021
nephron tubule morphogenesis GO:0072078 1 0.021
protein metabolic process GO:0019538 183 0.021
skeletal system morphogenesis GO:0048705 102 0.021
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.021
regulation of microtubule cytoskeleton organization GO:0070507 3 0.021
regulation of neuron projection development GO:0010975 40 0.021
spinal cord development GO:0021510 46 0.021
negative regulation of catabolic process GO:0009895 3 0.020
cranial nerve development GO:0021545 42 0.020
gtp catabolic process GO:0006184 2 0.020
mesenchymal cell development GO:0014031 78 0.020
Zebrafish
nucleocytoplasmic transport GO:0006913 4 0.020
regulation of biological quality GO:0065008 263 0.020
Mouse
nuclear transport GO:0051169 4 0.020
positive regulation of cell cycle GO:0045787 3 0.020
skeletal system development GO:0001501 181 0.020
negative regulation of signaling GO:0023057 96 0.019
regulation of blood vessel size GO:0050880 2 0.019
connective tissue development GO:0061448 99 0.019
regulation of microtubule depolymerization GO:0031114 1 0.019
gland development GO:0048732 143 0.019
amino acid transport GO:0006865 2 0.019
muscle structure development GO:0061061 196 0.019
positive regulation of transport GO:0051050 2 0.019
regulation of cell migration GO:0030334 40 0.019
ion homeostasis GO:0050801 41 0.019
establishment of protein localization to organelle GO:0072594 4 0.018
preganglionic parasympathetic nervous system development GO:0021783 6 0.018
cell matrix adhesion GO:0007160 4 0.018
Mouse
regulation of anatomical structure morphogenesis GO:0022603 130 0.018
Mouse
establishment of localization GO:0051234 244 0.018
regulation of growth GO:0040008 42 0.018
ventral spinal cord development GO:0021517 35 0.018
female sex differentiation GO:0046660 4 0.018
carboxylic acid catabolic process GO:0046395 3 0.018
response to organic substance GO:0010033 153 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.018
single organism membrane fusion GO:0044801 2 0.018
regulation of apoptotic process GO:0042981 98 0.018
inner ear development GO:0048839 126 0.018
determination of dorsal identity GO:0048263 13 0.017
bmp signaling pathway GO:0030509 52 0.017
regulation of cellular component organization GO:0051128 86 0.017
Mouse
endosomal transport GO:0016197 2 0.017
nerve development GO:0021675 45 0.017
negative regulation of response to stimulus GO:0048585 104 0.017
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.017
purine nucleotide biosynthetic process GO:0006164 20 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.017
septum transversum development GO:0003343 4 0.017
macromolecular complex disassembly GO:0032984 1 0.017
positive regulation of epithelial cell differentiation GO:0030858 2 0.017
positive regulation of cell death GO:0010942 29 0.017
regulation of behavior GO:0050795 24 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.016
branchiomotor neuron axon guidance GO:0021785 1 0.016
central nervous system neuron differentiation GO:0021953 74 0.016
response to growth factor GO:0070848 39 0.016
embryonic skeletal system morphogenesis GO:0048704 93 0.016
mesodermal cell migration GO:0008078 12 0.016
positive regulation of cytoskeleton organization GO:0051495 3 0.016
protein complex disassembly GO:0043241 1 0.016
cellular component biogenesis GO:0044085 178 0.016
positive regulation of multicellular organismal process GO:0051240 52 0.016
lymph vessel development GO:0001945 27 0.016
cytoskeleton organization GO:0007010 96 0.016
Mouse
small molecule metabolic process GO:0044281 77 0.016
immune system development GO:0002520 191 0.016
nuclear import GO:0051170 3 0.015
forebrain development GO:0030900 96 0.015
regulation of tube size GO:0035150 2 0.015
tissue regeneration GO:0042246 74 0.015
positive regulation of rna metabolic process GO:0051254 59 0.015
regulation of developmental growth GO:0048638 38 0.015
catechol containing compound metabolic process GO:0009712 2 0.015
morphogenesis of an epithelial sheet GO:0002011 49 0.015
somitogenesis GO:0001756 87 0.015
lateral line system development GO:0048925 76 0.015
positive regulation of blood circulation GO:1903524 2 0.015
regulation of anatomical structure size GO:0090066 33 0.015
regulation of cytoplasmic transport GO:1903649 4 0.015
regulation of protein complex assembly GO:0043254 3 0.014
blastoderm segmentation GO:0007350 6 0.014
astrocyte differentiation GO:0048708 1 0.014
regulation of signaling GO:0023051 235 0.014
regulation of stem cell differentiation GO:2000736 4 0.014
protein import into nucleus GO:0006606 3 0.014
nucleotide biosynthetic process GO:0009165 21 0.014
positive regulation of endothelial cell differentiation GO:0045603 2 0.014
positive regulation of muscle organ development GO:0048636 1 0.014
kidney development GO:0001822 92 0.014
proepicardium development GO:0003342 4 0.014
lateral inhibition GO:0046331 1 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
positive regulation of cellular component biogenesis GO:0044089 3 0.014
branching morphogenesis of a nerve GO:0048755 4 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.013
neural retina development GO:0003407 49 0.013
embryonic appendage morphogenesis GO:0035113 30 0.013
regulation of protein transport GO:0051223 3 0.013
phosphorus metabolic process GO:0006793 109 0.013
guanosine containing compound catabolic process GO:1901069 2 0.013
cell migration involved in gastrulation GO:0042074 79 0.013
positive regulation of secretion GO:0051047 1 0.013
regulation of endothelial cell differentiation GO:0045601 3 0.013
regulation of extent of cell growth GO:0061387 29 0.013
mechanoreceptor differentiation GO:0042490 37 0.013
immune system process GO:0002376 241 0.013
epithelial cell differentiation GO:0030855 116 0.013
hypothalamus cell differentiation GO:0021979 4 0.013
regulation of neuron differentiation GO:0045664 56 0.013
appendage morphogenesis GO:0035107 56 0.013
regulation of locomotion GO:0040012 55 0.013
regulation of protein complex disassembly GO:0043244 1 0.013
regulation of metal ion transport GO:0010959 4 0.013
multi organism process GO:0051704 134 0.013
single organism transport GO:0044765 206 0.013
cellular protein complex disassembly GO:0043624 1 0.012
compound eye development GO:0048749 2 0.012
positive regulation of cell differentiation GO:0045597 30 0.012
actin polymerization or depolymerization GO:0008154 2 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.012
regulation of protein localization to nucleus GO:1900180 2 0.012
spinal cord motor neuron differentiation GO:0021522 26 0.012
cellular protein metabolic process GO:0044267 129 0.012
segment polarity determination GO:0007367 1 0.012
inner ear receptor cell differentiation GO:0060113 29 0.012
small molecule catabolic process GO:0044282 3 0.012
golgi organization GO:0007030 1 0.012
positive regulation of neutrophil migration GO:1902624 0 0.012
single organism nuclear import GO:1902593 3 0.012
lymphangiogenesis GO:0001946 25 0.012
positive regulation of apoptotic process GO:0043065 29 0.012
regulation of cell projection assembly GO:0060491 4 0.012
response to radiation GO:0009314 51 0.012
ion transmembrane transport GO:0034220 91 0.012
embryonic organ morphogenesis GO:0048562 274 0.012
response to stress GO:0006950 263 0.012
stem cell proliferation GO:0072089 4 0.012
single organism metabolic process GO:0044710 217 0.012
heart valve formation GO:0003188 4 0.012
liver development GO:0001889 96 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
axon extension involved in axon guidance GO:0048846 10 0.011
cardiac chamber development GO:0003205 19 0.011
response to external biotic stimulus GO:0043207 97 0.011
mesoderm development GO:0007498 88 0.011
catecholamine metabolic process GO:0006584 2 0.011
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 4 0.011
negative regulation of blood circulation GO:1903523 2 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
muscle organ development GO:0007517 101 0.011
positive regulation of metabolic process GO:0009893 108 0.011
organelle fusion GO:0048284 3 0.011
maternal determination of anterior posterior axis embryo GO:0008358 4 0.011
embryonic digestive tract development GO:0048566 4 0.011
renal system development GO:0072001 94 0.011
g protein coupled receptor signaling pathway GO:0007186 74 0.011
regulation of ion transport GO:0043269 22 0.011
sympathetic ganglion development GO:0061549 2 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
negative regulation of cell communication GO:0010648 96 0.011
angiogenesis GO:0001525 158 0.011
organonitrogen compound biosynthetic process GO:1901566 47 0.011
regulation of bone mineralization GO:0030500 2 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
death GO:0016265 121 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.010
segmentation GO:0035282 97 0.010
nephron epithelium morphogenesis GO:0072088 1 0.010
neurological system process GO:0050877 62 0.010
cardiac chamber morphogenesis GO:0003206 12 0.010
positive regulation of endothelial cell proliferation GO:0001938 1 0.010
response to alkaloid GO:0043279 2 0.010
glial cell migration GO:0008347 3 0.010
regulation of vasculature development GO:1901342 33 0.010
Mouse
regulation of cell matrix adhesion GO:0001952 1 0.010
Mouse
positive regulation of catabolic process GO:0009896 4 0.010
positive regulation of rna biosynthetic process GO:1902680 57 0.010
maintenance of location GO:0051235 4 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.010

sema3e disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.062
cardiovascular system disease DOID:1287 0 0.023
musculoskeletal system disease DOID:17 0 0.022
nervous system disease DOID:863 0 0.021
bone disease DOID:0080001 0 0.017
connective tissue disease DOID:65 0 0.017
disease of metabolism DOID:0014667 0 0.014
inherited metabolic disorder DOID:655 0 0.014
heart disease DOID:114 0 0.013