Danio rerio

0 known processes

sh3gl2

SH3-domain GRB2-like 2

(Aliases: zgc:55616,MGC55616)

sh3gl2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sodium ion transmembrane transport GO:0035725 21 0.381
neuron differentiation GO:0030182 353 0.330
regulation of biological quality GO:0065008 263 0.310
Fly
larval development GO:0002164 2 0.256
monovalent inorganic cation transport GO:0015672 42 0.253
homeostatic process GO:0042592 142 0.190
cellular component movement GO:0006928 335 0.171
generation of neurons GO:0048699 385 0.168
specification of symmetry GO:0009799 204 0.159
regulation of metal ion transport GO:0010959 4 0.149
response to chemical GO:0042221 320 0.136
regulation of sodium ion transport GO:0002028 2 0.136
inorganic cation transmembrane transport GO:0098662 50 0.134
regulation of ion transmembrane transporter activity GO:0032412 2 0.124
cation transmembrane transport GO:0098655 65 0.116
regulation of cell shape GO:0008360 1 0.114
ion transport GO:0006811 114 0.113
metal ion transport GO:0030001 58 0.109
sodium ion transport GO:0006814 24 0.103
signal transduction GO:0007165 455 0.102
determination of heart left right asymmetry GO:0061371 117 0.100
neuromast development GO:0048884 46 0.099
cognition GO:0050890 1 0.099
embryonic organ development GO:0048568 381 0.094
specification of axis polarity GO:0065001 4 0.093
synaptic growth at neuromuscular junction GO:0051124 2 0.093
embryonic organ morphogenesis GO:0048562 274 0.092
regulation of sodium ion transmembrane transport GO:1902305 1 0.092
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.091
peripheral nervous system neuron differentiation GO:0048934 28 0.089
regulation of multicellular organism growth GO:0040014 4 0.088
lateral line system development GO:0048925 76 0.087
ion transmembrane transport GO:0034220 91 0.083
regulation of ph GO:0006885 3 0.083
developmental growth GO:0048589 166 0.081
system process GO:0003008 185 0.081
single organism localization GO:1902578 225 0.081
Mouse Fly
epithelial tube morphogenesis GO:0060562 148 0.081
regulation of cellular biosynthetic process GO:0031326 245 0.077
long chain fatty acid metabolic process GO:0001676 1 0.077
maintenance of location GO:0051235 4 0.076
heart development GO:0007507 313 0.074
small molecule metabolic process GO:0044281 77 0.072
chordate embryonic development GO:0043009 271 0.071
head development GO:0060322 303 0.070
long chain fatty acid biosynthetic process GO:0042759 1 0.070
aging GO:0007568 2 0.070
chemical homeostasis GO:0048878 49 0.067
fatty acid biosynthetic process GO:0006633 4 0.067
regulation of transmembrane transporter activity GO:0022898 2 0.065
sensory organ morphogenesis GO:0090596 200 0.063
cell surface receptor signaling pathway GO:0007166 325 0.061
multicellular organism growth GO:0035264 4 0.060
regulation of signaling GO:0023051 235 0.058
regulation of cell communication GO:0010646 232 0.058
embryonic skeletal system development GO:0048706 97 0.057
response to stress GO:0006950 263 0.057
regulation of cellular metabolic process GO:0031323 320 0.057
Mouse
eye development GO:0001654 277 0.056
membrane repolarization GO:0086009 2 0.056
brain development GO:0007420 293 0.053
axon ensheathment in central nervous system GO:0032291 2 0.052
central nervous system development GO:0007417 387 0.050
blood vessel morphogenesis GO:0048514 216 0.049
Zebrafish
transmembrane transport GO:0055085 120 0.048
ion homeostasis GO:0050801 41 0.047
regulation of metabolic process GO:0019222 359 0.046
Mouse
sensory organ development GO:0007423 393 0.046
embryonic skeletal system morphogenesis GO:0048704 93 0.046
neurological system process GO:0050877 62 0.046
regulation of synapse assembly GO:0051963 3 0.045
determination of bilateral symmetry GO:0009855 204 0.044
ph reduction GO:0045851 1 0.044
single organism transport GO:0044765 206 0.044
Mouse Fly
nitrogen compound metabolic process GO:0006807 319 0.044
adult behavior GO:0030534 2 0.043
vasculature development GO:0001944 278 0.043
Zebrafish
positive regulation of catabolic process GO:0009896 4 0.042
organelle organization GO:0006996 227 0.042
axon development GO:0061564 166 0.042
cell projection organization GO:0030030 284 0.041
organic acid metabolic process GO:0006082 31 0.041
central nervous system neuron differentiation GO:0021953 74 0.041
regulation of nucleotide catabolic process GO:0030811 2 0.041
organic substance biosynthetic process GO:1901576 289 0.041
neuron development GO:0048666 262 0.040
embryo development ending in birth or egg hatching GO:0009792 271 0.040
regulation of nitrogen compound metabolic process GO:0051171 251 0.040
gtp catabolic process GO:0006184 2 0.040
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.039
organonitrogen compound metabolic process GO:1901564 74 0.037
action potential GO:0001508 19 0.037
transport GO:0006810 220 0.037
Mouse Worm Fly
embryonic heart tube development GO:0035050 133 0.036
response to hormone GO:0009725 48 0.036
syncytium formation by plasma membrane fusion GO:0000768 12 0.036
cation transport GO:0006812 81 0.036
meiotic nuclear division GO:0007126 4 0.036
negative regulation of cellular process GO:0048523 283 0.036
muscle structure development GO:0061061 196 0.035
chemosensory behavior GO:0007635 1 0.035
regulation of developmental process GO:0050793 247 0.035
positive regulation of biological process GO:0048518 253 0.035
Worm
cellular nitrogen compound metabolic process GO:0034641 290 0.035
locomotory behavior GO:0007626 34 0.034
digestive system development GO:0055123 289 0.034
regulation of intracellular ph GO:0051453 1 0.034
growth GO:0040007 174 0.034
cell migration GO:0016477 237 0.033
skeletal muscle organ development GO:0060538 78 0.033
cellular sodium ion homeostasis GO:0006883 1 0.033
localization of cell GO:0051674 244 0.033
gtp metabolic process GO:0046039 4 0.033
regulation of nucleoside metabolic process GO:0009118 2 0.032
protein metabolic process GO:0019538 183 0.032
skeletal system development GO:0001501 181 0.032
apoptotic process GO:0006915 116 0.032
mechanosensory behavior GO:0007638 2 0.032
phosphorus metabolic process GO:0006793 109 0.031
positive regulation of cellular catabolic process GO:0031331 3 0.031
regulation of gtp catabolic process GO:0033124 2 0.030
regeneration GO:0031099 91 0.030
angiogenesis GO:0001525 158 0.030
regulation of protein transport GO:0051223 3 0.030
single organism metabolic process GO:0044710 217 0.030
Mouse
morphogenesis of an epithelium GO:0002009 333 0.029
rna modification GO:0009451 2 0.029
neuron projection development GO:0031175 180 0.029
regulation of multicellular organismal process GO:0051239 277 0.028
guanosine containing compound catabolic process GO:1901069 2 0.028
regulation of primary metabolic process GO:0080090 311 0.028
nerve development GO:0021675 45 0.028
establishment of localization GO:0051234 244 0.028
Mouse Worm Fly
regulation of transporter activity GO:0032409 2 0.028
gene expression GO:0010467 252 0.027
single organism organelle organization GO:1902589 199 0.027
regulation of nucleotide metabolic process GO:0006140 17 0.027
muscle organ development GO:0007517 101 0.027
cell cycle g1 s phase transition GO:0044843 1 0.027
heart looping GO:0001947 94 0.026
cell morphogenesis GO:0000902 289 0.026
regulation of cellular component organization GO:0051128 86 0.026
Mouse
regulation of reproductive process GO:2000241 4 0.026
metal ion homeostasis GO:0055065 26 0.026
exocytosis GO:0006887 1 0.025
oxoacid metabolic process GO:0043436 31 0.025
neuroblast proliferation GO:0007405 2 0.025
response to external stimulus GO:0009605 264 0.025
cell motility GO:0048870 244 0.025
tube morphogenesis GO:0035239 349 0.025
lipid storage GO:0019915 1 0.024
lipid metabolic process GO:0006629 52 0.024
response to wounding GO:0009611 116 0.024
transmission of nerve impulse GO:0019226 19 0.023
regulation of cell development GO:0060284 100 0.023
regulation of purine nucleotide catabolic process GO:0033121 2 0.023
embryonic heart tube morphogenesis GO:0003143 108 0.023
heterocycle metabolic process GO:0046483 290 0.023
regulation of establishment of protein localization GO:0070201 4 0.023
cellular component biogenesis GO:0044085 178 0.023
regulation of cytoplasmic transport GO:1903649 4 0.023
regulation of cell morphogenesis GO:0022604 42 0.023
regulation of anatomical structure morphogenesis GO:0022603 130 0.022
regulation of purine nucleotide metabolic process GO:1900542 17 0.022
multicellular organismal reproductive process GO:0048609 35 0.022
guanosine containing compound metabolic process GO:1901068 4 0.021
single organism biosynthetic process GO:0044711 71 0.021
positive regulation of cytoskeleton organization GO:0051495 3 0.021
regulation of localization GO:0032879 104 0.021
Mouse
carboxylic acid metabolic process GO:0019752 22 0.021
cellular protein modification process GO:0006464 100 0.021
regulation of cell projection organization GO:0031344 44 0.021
cartilage development GO:0051216 96 0.021
cellular component assembly GO:0022607 170 0.020
cation homeostasis GO:0055080 33 0.020
axonogenesis GO:0007409 152 0.020
neuron projection regeneration GO:0031102 16 0.020
nucleobase containing compound metabolic process GO:0006139 274 0.020
negative regulation of biological process GO:0048519 304 0.020
regulation of hormone secretion GO:0046883 2 0.020
apical junction assembly GO:0043297 1 0.020
multi organism process GO:0051704 134 0.020
monocarboxylic acid biosynthetic process GO:0072330 12 0.020
regulation of intracellular protein transport GO:0033157 3 0.020
protein stabilization GO:0050821 2 0.020
modification dependent protein catabolic process GO:0019941 3 0.020
regulation of cell projection assembly GO:0060491 4 0.020
ventricular cardiac muscle tissue development GO:0003229 3 0.020
carboxylic acid biosynthetic process GO:0046394 12 0.020
organophosphate metabolic process GO:0019637 37 0.020
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.019
regulation of membrane potential GO:0042391 23 0.019
heterocycle biosynthetic process GO:0018130 215 0.019
regulation of biosynthetic process GO:0009889 250 0.019
cellular response to endogenous stimulus GO:0071495 68 0.019
atp catabolic process GO:0006200 4 0.019
stem cell proliferation GO:0072089 4 0.019
semicircular canal development GO:0060872 24 0.019
cell part morphogenesis GO:0032990 246 0.018
inorganic ion transmembrane transport GO:0098660 57 0.018
rna localization GO:0006403 4 0.018
hormone secretion GO:0046879 2 0.018
g1 s transition of mitotic cell cycle GO:0000082 1 0.018
cellular macromolecule metabolic process GO:0044260 391 0.018
Mouse
determination of left right symmetry GO:0007368 179 0.018
single organism membrane fusion GO:0044801 2 0.018
organic cyclic compound metabolic process GO:1901360 301 0.018
nuclear transport GO:0051169 4 0.018
response to abiotic stimulus GO:0009628 122 0.018
carbohydrate derivative metabolic process GO:1901135 61 0.018
regulation of circadian rhythm GO:0042752 4 0.018
eye morphogenesis GO:0048592 144 0.018
embryonic viscerocranium morphogenesis GO:0048703 52 0.017
regulation of gtpase activity GO:0043087 2 0.017
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.017
regulation of ion transmembrane transport GO:0034765 18 0.017
regulation of filopodium assembly GO:0051489 2 0.017
morphogenesis of an epithelial sheet GO:0002011 49 0.017
cellular biosynthetic process GO:0044249 286 0.016
cytokinesis GO:0000910 3 0.016
negative regulation of signal transduction GO:0009968 94 0.016
camera type eye development GO:0043010 222 0.016
positive regulation of nucleoside metabolic process GO:0045979 1 0.016
sensory system development GO:0048880 76 0.016
visual perception GO:0007601 17 0.016
cell projection morphogenesis GO:0048858 244 0.016
developmental pigmentation GO:0048066 48 0.016
startle response GO:0001964 4 0.016
golgi vesicle transport GO:0048193 3 0.016
regulation of nucleocytoplasmic transport GO:0046822 2 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
single organism reproductive process GO:0044702 40 0.016
peripheral nervous system neuron axonogenesis GO:0048936 13 0.015
sequestering of metal ion GO:0051238 3 0.015
regulation of catalytic activity GO:0050790 55 0.015
biosynthetic process GO:0009058 294 0.015
cellular protein metabolic process GO:0044267 129 0.015
neural tube development GO:0021915 62 0.015
positive regulation of cellular component biogenesis GO:0044089 3 0.015
regulation of phosphate metabolic process GO:0019220 43 0.015
neuron projection morphogenesis GO:0048812 161 0.015
cellular component morphogenesis GO:0032989 336 0.015
regulation of sodium ion transmembrane transporter activity GO:2000649 1 0.015
cell projection assembly GO:0030031 64 0.015
positive regulation of cellular process GO:0048522 201 0.015
Worm
cellular response to chemical stimulus GO:0070887 157 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.015
establishment of endothelial barrier GO:0061028 3 0.014
nucleobase containing small molecule metabolic process GO:0055086 32 0.014
ear morphogenesis GO:0042471 64 0.014
cellular lipid metabolic process GO:0044255 36 0.014
blood vessel development GO:0001568 246 0.014
Zebrafish
heart morphogenesis GO:0003007 156 0.014
establishment of localization in cell GO:0051649 77 0.014
Mouse Fly
peripheral nervous system development GO:0007422 55 0.014
lateral line development GO:0048882 66 0.014
peptidyl serine modification GO:0018209 2 0.014
membrane hyperpolarization GO:0060081 1 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.014
cell cycle g2 m phase transition GO:0044839 4 0.014
regulation of wnt signaling pathway GO:0030111 53 0.014
cell cell signaling GO:0007267 52 0.014
Mouse Fly
pigmentation GO:0043473 85 0.013
erythrocyte differentiation GO:0030218 54 0.013
cellular response to external stimulus GO:0071496 2 0.013
sleep GO:0030431 1 0.013
response to monosaccharide GO:0034284 3 0.013
macromolecule localization GO:0033036 54 0.013
positive regulation of signaling GO:0023056 56 0.013
single fertilization GO:0007338 3 0.013
axon cargo transport GO:0008088 2 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
smooth muscle contraction GO:0006939 2 0.013
regulation of dna templated transcription in response to stress GO:0043620 0 0.013
inositol lipid mediated signaling GO:0048017 2 0.013
organelle fusion GO:0048284 3 0.013
homologous chromosome segregation GO:0045143 1 0.013
nucleoside monophosphate catabolic process GO:0009125 4 0.013
energy reserve metabolic process GO:0006112 2 0.013
catechol containing compound metabolic process GO:0009712 2 0.012
cranial nerve development GO:0021545 42 0.012
organic acid biosynthetic process GO:0016053 12 0.012
phagocytosis GO:0006909 3 0.012
protein modification process GO:0036211 100 0.012
syncytium formation GO:0006949 12 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.012
cellular response to organic substance GO:0071310 105 0.012
skeletal system morphogenesis GO:0048705 102 0.012
cell cycle GO:0007049 93 0.012
cell morphogenesis involved in differentiation GO:0000904 195 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
regulation of cell differentiation GO:0045595 142 0.012
establishment of protein localization to organelle GO:0072594 4 0.012
dopaminergic neuron differentiation GO:0071542 14 0.012
cell junction organization GO:0034330 11 0.012
cell growth GO:0016049 57 0.012
ensheathment of neurons GO:0007272 18 0.012
modification dependent macromolecule catabolic process GO:0043632 3 0.012
single organism cell adhesion GO:0098602 29 0.012
blood circulation GO:0008015 87 0.012
regulation of homeostatic process GO:0032844 9 0.012
single organism behavior GO:0044708 24 0.012
fatty acid elongation unsaturated fatty acid GO:0019368 1 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.011
purine nucleoside monophosphate catabolic process GO:0009128 4 0.011
positive regulation of transport GO:0051050 2 0.011
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.011
ear development GO:0043583 127 0.011
cellular potassium ion transport GO:0071804 10 0.011
negative regulation of cellular biosynthetic process GO:0031327 55 0.011
forebrain development GO:0030900 96 0.011
behavior GO:0007610 74 0.011
regulation of glial cell differentiation GO:0045685 4 0.011
mitotic cell cycle process GO:1903047 48 0.011
mitotic cell cycle GO:0000278 64 0.011
negative regulation of catabolic process GO:0009895 3 0.011
taxis GO:0042330 109 0.011
regulation of cell motility GO:2000145 46 0.011
nucleocytoplasmic transport GO:0006913 4 0.011
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.011
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.011
regulation of response to stimulus GO:0048583 269 0.011
central nervous system myelination GO:0022010 2 0.011
regulation of nucleic acid templated transcription GO:1903506 213 0.011
response to axon injury GO:0048678 14 0.011
response to endogenous stimulus GO:0009719 83 0.011
positive regulation of cell adhesion GO:0045785 1 0.011
response to growth factor GO:0070848 39 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.011
membrane invagination GO:0010324 1 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
regulation of nervous system development GO:0051960 90 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
cellular response to stress GO:0033554 62 0.011
detection of chemical stimulus GO:0009593 4 0.011
aromatic compound biosynthetic process GO:0019438 217 0.010
nucleobase containing compound biosynthetic process GO:0034654 205 0.010
peptidyl serine phosphorylation GO:0018105 1 0.010
response to hypoxia GO:0001666 25 0.010
medulla oblongata development GO:0021550 4 0.010
cell migration involved in heart development GO:0060973 22 0.010
regulation of protein catabolic process GO:0042176 1 0.010
regulation of protein ubiquitination GO:0031396 3 0.010
response to temperature stimulus GO:0009266 15 0.010
regulation of gene expression GO:0010468 265 0.010
positive regulation of apoptotic signaling pathway GO:2001235 1 0.010
regulation of molecular function GO:0065009 70 0.010
olfactory placode morphogenesis GO:0071699 7 0.010
regulation of stem cell proliferation GO:0072091 2 0.010
anterior posterior pattern specification GO:0009952 152 0.010
regulation of mitochondrion organization GO:0010821 1 0.010
locomotor rhythm GO:0045475 3 0.010
negative regulation of cell death GO:0060548 60 0.010
locomotion GO:0040011 313 0.010
cell cell junction organization GO:0045216 10 0.010

sh3gl2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
hematopoietic system disease DOID:74 0 0.016
immune system disease DOID:2914 0 0.016
leukodystrophy DOID:10579 0 0.015
nervous system disease DOID:863 0 0.015
central nervous system disease DOID:331 0 0.015
cerebral degeneration DOID:1443 0 0.015
brain disease DOID:936 0 0.015