Danio rerio

260 known processes

shha

sonic hedgehog a

(Aliases: shh,wu:fc83d08,syu,vhh1)

shha biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
retinal ganglion cell axon guidance GO:0031290 35 1.000
embryonic organ development GO:0048568 381 1.000
limb bud formation GO:0060174 2 1.000
Mouse
pituitary gland development GO:0021983 16 1.000
blood vessel morphogenesis GO:0048514 216 1.000
Mouse
diencephalon development GO:0021536 58 1.000
central nervous system development GO:0007417 387 1.000
ventral spinal cord interneuron fate commitment GO:0060579 3 0.999
ventral spinal cord interneuron specification GO:0021521 3 0.999
bmp signaling pathway involved in heart development GO:0061312 15 0.999
floor plate formation GO:0021508 12 0.999
adenohypophysis development GO:0021984 15 0.999
bmp signaling pathway involved in heart jogging GO:0003303 14 0.999
brain development GO:0007420 293 0.999
dorsal ventral neural tube patterning GO:0021904 1 0.998
Mouse
cell fate specification involved in pattern specification GO:0060573 3 0.998
neural tube development GO:0021915 62 0.998
cell migration GO:0016477 237 0.998
Mouse Fly
cellular biosynthetic process GO:0044249 286 0.998
Mouse Fly
pronephros development GO:0048793 69 0.998
digestive tract development GO:0048565 265 0.998
positive regulation of gene expression GO:0010628 71 0.998
Mouse
spinal cord motor neuron cell fate specification GO:0021520 8 0.997
digestive system development GO:0055123 289 0.997
regulation of primary metabolic process GO:0080090 311 0.997
positive regulation of cellular process GO:0048522 201 0.997
Mouse Fly
photoreceptor cell development GO:0042461 40 0.997
forebrain development GO:0030900 96 0.997
specification of symmetry GO:0009799 204 0.997
eye morphogenesis GO:0048592 144 0.996
epithelial tube morphogenesis GO:0060562 148 0.996
localization of cell GO:0051674 244 0.996
Mouse Fly
eye development GO:0001654 277 0.996
regulation of gene expression GO:0010468 265 0.996
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.996
signal transduction GO:0007165 455 0.996
tube morphogenesis GO:0035239 349 0.996
bmp signaling pathway GO:0030509 52 0.995
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.995
Mouse
floor plate morphogenesis GO:0033505 12 0.995
regulation of macromolecule biosynthetic process GO:0010556 225 0.994
spinal cord dorsal ventral patterning GO:0021513 5 0.994
Mouse
cell projection organization GO:0030030 284 0.994
neuron fate specification GO:0048665 20 0.994
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.994
photoreceptor cell differentiation GO:0046530 55 0.993
smoothened signaling pathway GO:0007224 30 0.993
sensory organ morphogenesis GO:0090596 200 0.993
notochord development GO:0030903 54 0.992
cell morphogenesis involved in differentiation GO:0000904 195 0.992
positive regulation of biological process GO:0048518 253 0.992
Mouse Worm Fly
motor neuron axon guidance GO:0008045 23 0.992
cell surface receptor signaling pathway GO:0007166 325 0.991
cellular component morphogenesis GO:0032989 336 0.991
generation of neurons GO:0048699 385 0.991
cell motility GO:0048870 244 0.990
Mouse Fly
forebrain dorsal ventral pattern formation GO:0021798 1 0.990
branching morphogenesis of an epithelial tube GO:0048754 15 0.989
Mouse
diencephalon morphogenesis GO:0048852 5 0.989
regulation of macromolecule metabolic process GO:0060255 317 0.989
nephron development GO:0072006 31 0.989
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.988
cellular macromolecule metabolic process GO:0044260 391 0.987
Mouse Fly
determination of left right symmetry GO:0007368 179 0.987
regulation of signal transduction GO:0009966 225 0.987
single organism reproductive process GO:0044702 40 0.987
Mouse Fly
regulation of eye photoreceptor cell development GO:0042478 2 0.987
odontogenesis of dentin containing tooth GO:0042475 1 0.986
Mouse
nucleic acid templated transcription GO:0097659 181 0.986
Mouse Fly
mesenchymal cell development GO:0014031 78 0.986
Mouse
morphogenesis of a branching epithelium GO:0061138 16 0.985
Mouse
developmental growth GO:0048589 166 0.985
Mouse Worm
regulation of metabolic process GO:0019222 359 0.985
embryonic organ morphogenesis GO:0048562 274 0.984
kidney development GO:0001822 92 0.984
neural crest cell development GO:0014032 62 0.983
Mouse
axon guidance GO:0007411 86 0.982
appendage development GO:0048736 80 0.981
neuron projection guidance GO:0097485 86 0.980
positive regulation of signal transduction GO:0009967 56 0.980
Mouse Fly
blood vessel development GO:0001568 246 0.980
Mouse
cellular component movement GO:0006928 335 0.980
mesoderm development GO:0007498 88 0.977
Mouse Fly
response to external stimulus GO:0009605 264 0.977
morphogenesis of an epithelial fold GO:0060571 1 0.976
Mouse
morphogenesis of an epithelium GO:0002009 333 0.976
inner ear development GO:0048839 126 0.974
embryonic heart tube morphogenesis GO:0003143 108 0.973
ventral spinal cord development GO:0021517 35 0.973
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.972
Mouse Fly
neural tube patterning GO:0021532 33 0.970
Mouse
eye photoreceptor cell development GO:0042462 30 0.969
axial mesoderm formation GO:0048320 4 0.968
enzyme linked receptor protein signaling pathway GO:0007167 106 0.967
regulation of multicellular organismal process GO:0051239 277 0.966
atrial ventricular junction remodeling GO:0003294 2 0.966
response to chemical GO:0042221 320 0.965
urogenital system development GO:0001655 97 0.965
mesoderm morphogenesis GO:0048332 51 0.964
neuron development GO:0048666 262 0.963
appendage morphogenesis GO:0035107 56 0.963
heart jogging GO:0003146 40 0.963
abducens nucleus development GO:0021742 2 0.963
osteoblast differentiation GO:0001649 5 0.961
Zebrafish Mouse
axon development GO:0061564 166 0.961
nephron tubule morphogenesis GO:0072078 1 0.960
Mouse
camera type eye morphogenesis GO:0048593 108 0.959
regulation of cellular metabolic process GO:0031323 320 0.958
regulation of biosynthetic process GO:0009889 250 0.956
regulation of developmental process GO:0050793 247 0.956
embryonic pectoral fin morphogenesis GO:0035118 24 0.956
regulation of localization GO:0032879 104 0.954
Mouse Fly
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.952
macromolecule biosynthetic process GO:0009059 227 0.952
Mouse Fly
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.952
Mouse
cell cycle GO:0007049 93 0.952
Fly
notochord morphogenesis GO:0048570 17 0.951
neuron fate commitment GO:0048663 26 0.951
embryonic camera type eye development GO:0031076 29 0.951
skeletal system development GO:0001501 181 0.950
organ formation GO:0048645 17 0.950
Mouse Fly
neural crest cell migration GO:0001755 42 0.950
Mouse
neuron projection morphogenesis GO:0048812 161 0.950
rna biosynthetic process GO:0032774 181 0.949
Mouse Fly
chemotaxis GO:0006935 104 0.948
glandular epithelial cell differentiation GO:0002067 9 0.947
cellular response to chemical stimulus GO:0070887 157 0.947
digestive tract morphogenesis GO:0048546 231 0.946
gene expression GO:0010467 252 0.946
optic nerve morphogenesis GO:0021631 6 0.946
gland development GO:0048732 143 0.945
system process GO:0003008 185 0.945
biosynthetic process GO:0009058 294 0.943
Mouse Fly
pancreas development GO:0031016 84 0.942
patterning of blood vessels GO:0001569 15 0.942
Mouse
regulation of signaling GO:0023051 235 0.941
sensory organ development GO:0007423 393 0.940
aromatic compound biosynthetic process GO:0019438 217 0.940
Mouse Fly
response to organic substance GO:0010033 153 0.939
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.939
Zebrafish
foregut morphogenesis GO:0007440 4 0.937
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.937
astrocyte differentiation GO:0048708 1 0.936
Mouse
renal system development GO:0072001 94 0.935
axonogenesis GO:0007409 152 0.933
establishment of localization GO:0051234 244 0.931
Mouse Fly
positive regulation of rna metabolic process GO:0051254 59 0.931
Mouse
regulation of stem cell proliferation GO:0072091 2 0.929
Mouse
positive regulation of stem cell proliferation GO:2000648 1 0.926
Mouse
artery development GO:0060840 22 0.924
Mouse
heart development GO:0007507 313 0.922
anterior posterior axon guidance GO:0033564 5 0.922
head development GO:0060322 303 0.920
bmp signaling pathway involved in determination of left right symmetry GO:0003154 14 0.917
mesenchymal cell differentiation GO:0048762 87 0.917
Mouse
positive regulation of smoothened signaling pathway GO:0045880 5 0.916
Mouse
muscle cell differentiation GO:0042692 139 0.913
determination of heart left right asymmetry GO:0061371 117 0.911
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.910
Mouse
cerebellar cortex development GO:0021695 5 0.907
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.907
organic substance biosynthetic process GO:1901576 289 0.905
Mouse Fly
immune system process GO:0002376 241 0.903
Mouse
eye photoreceptor cell differentiation GO:0001754 45 0.902
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.901
Mouse
cell cell adhesion involved in mesendodermal cell migration GO:0003370 1 0.901
spinal cord motor neuron differentiation GO:0021522 26 0.900
positive regulation of metabolic process GO:0009893 108 0.900
Mouse
embryonic appendage morphogenesis GO:0035113 30 0.898
Mouse
response to stress GO:0006950 263 0.896
Mouse
cellular response to organic substance GO:0071310 105 0.894
cellular macromolecule biosynthetic process GO:0034645 224 0.894
Mouse Fly
neural crest cell differentiation GO:0014033 72 0.892
Mouse
epithelial cell differentiation GO:0030855 116 0.889
somatic motor neuron differentiation GO:0021523 5 0.884
developmental growth involved in morphogenesis GO:0060560 86 0.882
Mouse
telencephalon development GO:0021537 14 0.879
Mouse Fly
odontogenesis GO:0042476 9 0.879
glomerulus development GO:0032835 27 0.879
embryonic pattern specification GO:0009880 44 0.879
Fly
regulation of response to stimulus GO:0048583 269 0.879
cellular aromatic compound metabolic process GO:0006725 295 0.876
Mouse Fly
oligodendrocyte differentiation GO:0048709 23 0.870
Zebrafish Mouse
transcription from rna polymerase ii promoter GO:0006366 80 0.870
Mouse
regulation of heart morphogenesis GO:2000826 17 0.868
epithelial cell development GO:0002064 42 0.868
regionalization GO:0003002 274 0.860
negative regulation of gene expression GO:0010629 65 0.859
Mouse Fly
embryonic limb morphogenesis GO:0030326 2 0.851
Mouse
forebrain neuron development GO:0021884 7 0.848
regulation of smoothened signaling pathway GO:0008589 18 0.846
Mouse
muscle cell fate specification GO:0042694 5 0.846
cytoskeleton organization GO:0007010 96 0.845
Mouse
cell differentiation in spinal cord GO:0021515 40 0.844
taxis GO:0042330 109 0.843
positive regulation of cell proliferation GO:0008284 15 0.841
Mouse
growth GO:0040007 174 0.840
Mouse Worm
muscle structure development GO:0061061 196 0.839
heart looping GO:0001947 94 0.834
neuron projection development GO:0031175 180 0.833
heterocycle metabolic process GO:0046483 290 0.832
Mouse Fly
central nervous system neuron differentiation GO:0021953 74 0.829
cellular nitrogen compound biosynthetic process GO:0044271 218 0.824
Mouse Fly
regulation of cell proliferation GO:0042127 37 0.821
cardiac chamber development GO:0003205 19 0.816
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.814
gastrulation GO:0007369 208 0.812
taste bud formation GO:0061195 3 0.809
cellular response to growth factor stimulus GO:0071363 39 0.809
endocrine system development GO:0035270 65 0.807
chordate embryonic development GO:0043009 271 0.807
segment polarity determination GO:0007367 1 0.803
Fly
camera type eye development GO:0043010 222 0.801
rostrocaudal neural tube patterning GO:0021903 29 0.801
positive regulation of cellular biosynthetic process GO:0031328 68 0.801
Mouse
regulation of nervous system development GO:0051960 90 0.798
Mouse
regulation of apoptotic process GO:0042981 98 0.797
Mouse
embryonic eye morphogenesis GO:0048048 30 0.795
positive regulation of macromolecule metabolic process GO:0010604 93 0.792
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.792
Mouse
regulation of transcription dna templated GO:0006355 213 0.790
periodic partitioning GO:0007365 1 0.789
Fly
embryonic skeletal system development GO:0048706 97 0.787
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.786
axial mesoderm development GO:0048318 10 0.784
embryonic heart tube development GO:0035050 133 0.783
outflow tract morphogenesis GO:0003151 1 0.779
vasculature development GO:0001944 278 0.777
Mouse
cell part morphogenesis GO:0032990 246 0.774
reproductive process GO:0022414 40 0.774
Mouse Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.770
apoptotic process GO:0006915 116 0.769
Mouse
hindbrain development GO:0030902 91 0.768
cell proliferation GO:0008283 80 0.768
morphogenesis of a branching structure GO:0001763 21 0.766
Mouse
response to nutrient GO:0007584 3 0.764
death GO:0016265 121 0.763
Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.762
Mouse Fly
positive regulation of striated muscle cell differentiation GO:0051155 1 0.760
Mouse
cell fate specification GO:0001708 68 0.759
oligodendrocyte cell fate specification GO:0021778 4 0.758
Zebrafish
forebrain generation of neurons GO:0021872 14 0.758
embryonic digestive tract morphogenesis GO:0048557 3 0.755
regulation of oligodendrocyte differentiation GO:0048713 1 0.751
Mouse
mesenchyme development GO:0060485 127 0.747
Mouse Fly
heart formation GO:0060914 13 0.746
Fly
anterior posterior pattern specification GO:0009952 152 0.746
heart field specification GO:0003128 1 0.743
cell migration involved in mesendoderm migration GO:0090134 2 0.743
negative regulation of neurogenesis GO:0050768 20 0.743
endodermal cell fate specification GO:0001714 17 0.743
embryonic digestive tract development GO:0048566 4 0.741
cell projection morphogenesis GO:0048858 244 0.741
limb morphogenesis GO:0035108 7 0.741
Mouse
spinal cord development GO:0021510 46 0.735
regulation of multicellular organismal development GO:2000026 223 0.729
notochord cell differentiation GO:0060034 18 0.720
kidney morphogenesis GO:0060993 15 0.720
Mouse
positive regulation of biosynthetic process GO:0009891 68 0.717
Mouse
ear morphogenesis GO:0042471 64 0.716
regulation of rna metabolic process GO:0051252 224 0.716
embryo development ending in birth or egg hatching GO:0009792 271 0.714
regulation of locomotion GO:0040012 55 0.714
Mouse Fly
negative regulation of cellular process GO:0048523 283 0.713
cell proliferation in hindbrain GO:0021534 4 0.710
Mouse
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.709
Fly
epithelial to mesenchymal transition GO:0001837 21 0.707
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.706
cellular nitrogen compound metabolic process GO:0034641 290 0.706
Mouse Fly
regeneration GO:0031099 91 0.706
positive regulation of response to stimulus GO:0048584 80 0.704
Mouse Fly
developmental process involved in reproduction GO:0003006 27 0.703
Mouse Fly
regulation of cell communication GO:0010646 232 0.697
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 15 0.694
retina development in camera type eye GO:0060041 146 0.692
nephron morphogenesis GO:0072028 2 0.688
Mouse
embryonic skeletal system morphogenesis GO:0048704 93 0.684
retinal rod cell development GO:0046548 4 0.682
positive regulation of epithelial cell differentiation GO:0030858 2 0.681
swim bladder morphogenesis GO:0048795 4 0.677
ventral spinal cord interneuron differentiation GO:0021514 12 0.677
regulation of cell death GO:0010941 103 0.676
Mouse
mesodermal cell fate specification GO:0007501 12 0.672
axis elongation involved in somitogenesis GO:0090245 2 0.672
inner ear morphogenesis GO:0042472 63 0.672
regulation of mesenchymal cell proliferation GO:0010464 1 0.669
Mouse
medial fin morphogenesis GO:0035141 14 0.666
striated muscle cell differentiation GO:0051146 129 0.662
cell morphogenesis GO:0000902 289 0.661
photoreceptor cell fate specification GO:0043704 1 0.659
endocardium development GO:0003157 9 0.657
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.655
axon extension GO:0048675 45 0.653
skeletal system morphogenesis GO:0048705 102 0.653
wnt signaling pathway involved in somitogenesis GO:0090244 2 0.648
response to growth factor GO:0070848 39 0.643
response to other organism GO:0051707 97 0.640
nitrogen compound metabolic process GO:0006807 319 0.640
Mouse Fly
renal tubule morphogenesis GO:0061333 1 0.635
Mouse
protein modification process GO:0036211 100 0.634
Fly
regulation of bmp signaling pathway GO:0030510 39 0.633
positive regulation of rna biosynthetic process GO:1902680 57 0.631
Mouse
forebrain regionalization GO:0021871 4 0.629
Mouse
mitotic cell cycle process GO:1903047 48 0.628
positive regulation of multicellular organismal process GO:0051240 52 0.626
Mouse Worm
invagination involved in gastrulation with mouth forming second GO:0055109 1 0.625
ameboidal type cell migration GO:0001667 143 0.624
Mouse Fly
pancreatic a cell development GO:0003322 2 0.618
respiratory system development GO:0060541 5 0.616
Mouse Fly
hindbrain morphogenesis GO:0021575 22 0.611
somitogenesis GO:0001756 87 0.608
peripheral nervous system development GO:0007422 55 0.608
endodermal digestive tract morphogenesis GO:0061031 2 0.608
response to wounding GO:0009611 116 0.600
Mouse
determination of bilateral symmetry GO:0009855 204 0.600
cerebellum development GO:0021549 17 0.595
morphogenesis of embryonic epithelium GO:0016331 30 0.590
regulation of cell development GO:0060284 100 0.574
Mouse
positive regulation of cell activation GO:0050867 1 0.572
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.568
Mouse
locomotion GO:0040011 313 0.564
glial cell differentiation GO:0010001 42 0.561
cellular response to retinoic acid GO:0071300 1 0.561
nephron epithelium morphogenesis GO:0072088 1 0.559
Mouse
forebrain neuron fate commitment GO:0021877 1 0.558
determination of left right asymmetry in nervous system GO:0035545 4 0.555
rna metabolic process GO:0016070 219 0.550
Mouse Fly
regulation of protein transport GO:0051223 3 0.549
Mouse Fly
response to carbohydrate GO:0009743 3 0.547
nucleobase containing compound metabolic process GO:0006139 274 0.547
Mouse Fly
positive regulation of signaling GO:0023056 56 0.546
Mouse Fly
phosphorylation GO:0016310 69 0.544
forebrain anterior posterior pattern specification GO:0021797 3 0.540
fin regeneration GO:0031101 51 0.540
negative regulation of cell death GO:0060548 60 0.540
Mouse
mesenchymal cell proliferation GO:0010463 1 0.539
Mouse
regulation of rna biosynthetic process GO:2001141 213 0.536
positive regulation of epithelial cell proliferation GO:0050679 1 0.533
Mouse
response to hexose GO:0009746 3 0.533
mesoderm formation GO:0001707 43 0.531
regulation of endodermal cell fate specification GO:0042663 15 0.528
transcription dna templated GO:0006351 181 0.525
Mouse Fly
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.524
regulation of cytokine production GO:0001817 3 0.524
negative regulation of biological process GO:0048519 304 0.511
response to organic cyclic compound GO:0014070 51 0.510
mesodermal cell fate commitment GO:0001710 14 0.508
neurological system process GO:0050877 62 0.505
ear development GO:0043583 127 0.501
forebrain morphogenesis GO:0048853 6 0.499
neural plate development GO:0001840 10 0.493
mesodermal cell differentiation GO:0048333 21 0.493
cell cycle process GO:0022402 53 0.493
atrioventricular valve formation GO:0003190 3 0.489
stem cell development GO:0048864 82 0.488
Mouse
glial cell fate specification GO:0021780 4 0.486
Zebrafish
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.481
cardiac atrium morphogenesis GO:0003209 2 0.478
photoreceptor cell fate commitment GO:0046552 1 0.469
fin development GO:0033333 77 0.468
negative regulation of signaling GO:0023057 96 0.458
Mouse
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.457
negative regulation of response to stimulus GO:0048585 104 0.455
Mouse
ventral midline development GO:0007418 13 0.447
gastrulation with mouth forming second GO:0001702 44 0.445
vasculogenesis GO:0001570 41 0.440
Mouse
single organism transport GO:0044765 206 0.439
Mouse Fly
nephron epithelium development GO:0072009 16 0.438
Mouse
response to monosaccharide GO:0034284 3 0.434
cartilage development GO:0051216 96 0.430
limb development GO:0060173 8 0.429
Mouse
semicircular canal development GO:0060872 24 0.425
response to lipid GO:0033993 60 0.423
formation of primary germ layer GO:0001704 62 0.422
regulation of nucleic acid templated transcription GO:1903506 213 0.416
nucleic acid metabolic process GO:0090304 244 0.413
Mouse Fly
response to alcohol GO:0097305 14 0.413
mesendoderm development GO:0048382 10 0.410
regulation of intracellular protein transport GO:0033157 3 0.410
Mouse Fly
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.407
Mouse
positive regulation of immune system process GO:0002684 17 0.405
Mouse
floor plate development GO:0033504 15 0.403
immune system development GO:0002520 191 0.403
Mouse
dopaminergic neuron differentiation GO:0071542 14 0.401
epithelial tube formation GO:0072175 19 0.399
somite development GO:0061053 96 0.397
positive regulation of cellular metabolic process GO:0031325 94 0.394
Mouse
reproductive structure development GO:0048608 5 0.392
Mouse Fly
determination of dorsal ventral asymmetry GO:0048262 34 0.391
negative regulation of transcription elongation from rna polymerase ii promoter GO:0034244 1 0.386
Mouse
somite specification GO:0001757 12 0.386
cardiac muscle cell differentiation GO:0055007 30 0.385
programmed cell death GO:0012501 119 0.375
Mouse
blood circulation GO:0008015 87 0.373
glial cell migration GO:0008347 3 0.373
Fly
neuron projection extension GO:1990138 45 0.373
response to biotic stimulus GO:0009607 97 0.371
gliogenesis GO:0042063 45 0.370
nucleobase containing compound biosynthetic process GO:0034654 205 0.369
Mouse Fly
hypophysis morphogenesis GO:0048850 5 0.367
somatic stem cell maintenance GO:0035019 1 0.366
optic nerve development GO:0021554 15 0.366
neuron migration GO:0001764 22 0.366
response to fibroblast growth factor GO:0071774 22 0.366
Fly
embryonic camera type eye formation GO:0060900 10 0.365
specification of organ position GO:0010159 3 0.364
epithelial cell morphogenesis GO:0003382 2 0.360
leukocyte proliferation GO:0070661 1 0.359
Mouse
endochondral bone morphogenesis GO:0060350 8 0.359
positive regulation of glial cell differentiation GO:0045687 1 0.358
Mouse
type b pancreatic cell development GO:0003323 4 0.353
intestinal epithelial cell differentiation GO:0060575 3 0.352
endocardial cushion morphogenesis GO:0003203 3 0.351
positive regulation of nervous system development GO:0051962 25 0.345
Mouse
specification of organ identity GO:0010092 2 0.342
cell cell adhesion involved in gastrulation GO:0070586 4 0.342
positive regulation of nucleic acid templated transcription GO:1903508 57 0.333
Mouse
regulation of axon extension GO:0030516 24 0.332
pericardium morphogenesis GO:0003344 1 0.331
patterning of lymph vessels GO:0060854 1 0.328
medial fin development GO:0033338 16 0.328
stem cell differentiation GO:0048863 117 0.328
basement membrane assembly GO:0070831 3 0.326
regulation of chondrocyte differentiation GO:0032330 1 0.326
fourth ventricle development GO:0021592 8 0.325
single organism localization GO:1902578 225 0.323
Mouse Fly
regulation of programmed cell death GO:0043067 101 0.319
Mouse
regulation of cellular component movement GO:0051270 55 0.319
Mouse Fly
tube formation GO:0035148 25 0.319
Mouse
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.317
retinal pigment epithelium development GO:0003406 8 0.317
cell migration involved in gastrulation GO:0042074 79 0.316
endodermal cell fate determination GO:0007493 2 0.312
proximal tubule development GO:0072014 3 0.312
axial mesoderm morphogenesis GO:0048319 8 0.308
segmentation GO:0035282 97 0.305
negative regulation of muscle organ development GO:0048635 5 0.305
spinal cord patterning GO:0021511 6 0.305
Mouse
cellular protein metabolic process GO:0044267 129 0.303
Mouse Fly
cardiocyte differentiation GO:0035051 44 0.303
negative regulation of neuron differentiation GO:0045665 10 0.302
stem cell proliferation GO:0072089 4 0.302
Mouse
fin morphogenesis GO:0033334 53 0.301
regulation of cell migration GO:0030334 40 0.301
Mouse Fly
negative regulation of apoptotic process GO:0043066 55 0.300
Mouse
proximal distal pattern formation GO:0009954 1 0.299
establishment of localization in cell GO:0051649 77 0.295
Mouse Fly
regulation of organ morphogenesis GO:2000027 35 0.294
midbrain hindbrain boundary development GO:0030917 23 0.294
cerebellum morphogenesis GO:0021587 10 0.290
organelle organization GO:0006996 227 0.287
Mouse
dorsal ventral pattern formation GO:0009953 125 0.287
cellular component biogenesis GO:0044085 178 0.285
Fly
establishment of cell polarity involved in gastrulation cell migration GO:0003379 2 0.282
negative regulation of cell migration GO:0030336 17 0.281
Mouse
smooth muscle tissue development GO:0048745 1 0.277
Mouse
detection of stimulus GO:0051606 29 0.277
forebrain neuron differentiation GO:0021879 14 0.276
aorta development GO:0035904 4 0.272
central nervous system neuron axonogenesis GO:0021955 18 0.270
Fly
glial cell development GO:0021782 20 0.268
Mouse
gamete generation GO:0007276 33 0.268
Fly
regulation of immune system process GO:0002682 34 0.266
Mouse
phagocytosis GO:0006909 3 0.265
establishment of cell polarity involved in mesendodermal cell migration GO:0003369 1 0.265
limbic system development GO:0021761 16 0.265
negative regulation of axon guidance GO:1902668 1 0.265
regulation of cell activation GO:0050865 1 0.263
Mouse
rhombomere development GO:0021546 19 0.260
regulation of protein localization to nucleus GO:1900180 2 0.260
Mouse Fly
nerve development GO:0021675 45 0.259
bone development GO:0060348 14 0.258
sensory perception of light stimulus GO:0050953 19 0.257
mononuclear cell proliferation GO:0032943 1 0.256
Mouse
regulation of glial cell differentiation GO:0045685 4 0.255
Mouse
ossification GO:0001503 23 0.253
Zebrafish Mouse
sexual reproduction GO:0019953 36 0.253
Fly
positive regulation of secretion by cell GO:1903532 1 0.251
positive regulation of transcription dna templated GO:0045893 57 0.250
Mouse
primary neural tube formation GO:0014020 1 0.249
regulation of protein targeting GO:1903533 2 0.248
Mouse Fly
positive regulation of neuron differentiation GO:0045666 12 0.246
neuron differentiation GO:0030182 353 0.239
multicellular organism growth GO:0035264 4 0.237
Worm
response to glucocorticoid GO:0051384 1 0.235
axial mesoderm structural organization GO:0048331 2 0.233
negative regulation of programmed cell death GO:0043069 58 0.232
Mouse
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.228
positive regulation of neuron apoptotic process GO:0043525 1 0.224
signal transduction downstream of smoothened GO:0007227 1 0.224
Mouse Fly
endocardial cushion development GO:0003197 6 0.223
oligodendrocyte development GO:0014003 7 0.221
Mouse
heart valve formation GO:0003188 4 0.221
metencephalon development GO:0022037 27 0.220
cellular response to lipid GO:0071396 39 0.220

shha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 0 0.726
disease of anatomical entity DOID:7 0 0.726
musculoskeletal system disease DOID:17 0 0.726
connective tissue disease DOID:65 0 0.726