Danio rerio

58 known processes

shhb

sonic hedgehog b

(Aliases: twh,twhh)

shhb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
head development GO:0060322 303 0.996
central nervous system development GO:0007417 387 0.995
sensory organ development GO:0007423 393 0.981
Zebrafish Mouse Fly
embryonic organ development GO:0048568 381 0.970
generation of neurons GO:0048699 385 0.966
chordate embryonic development GO:0043009 271 0.930
specification of symmetry GO:0009799 204 0.914
Zebrafish Mouse
localization of cell GO:0051674 244 0.899
Mouse Fly
central nervous system neuron differentiation GO:0021953 74 0.888
Zebrafish Mouse Fly
rna biosynthetic process GO:0032774 181 0.887
Mouse Fly
response to chemical GO:0042221 320 0.886
Zebrafish Mouse Fly
eye morphogenesis GO:0048592 144 0.885
Zebrafish Fly
determination of left right symmetry GO:0007368 179 0.884
Zebrafish Mouse
morphogenesis of an epithelium GO:0002009 333 0.875
Zebrafish Mouse Fly
eye development GO:0001654 277 0.861
Zebrafish Mouse Fly
neuron differentiation GO:0030182 353 0.854
determination of heart left right asymmetry GO:0061371 117 0.851
Zebrafish Mouse
heterocycle biosynthetic process GO:0018130 215 0.846
Mouse Fly
heart morphogenesis GO:0003007 156 0.841
Zebrafish Mouse Fly
aging GO:0007568 2 0.829
determination of bilateral symmetry GO:0009855 204 0.804
Zebrafish Mouse
camera type eye development GO:0043010 222 0.788
Zebrafish Mouse
tube morphogenesis GO:0035239 349 0.786
Zebrafish Mouse Fly
embryonic skeletal system morphogenesis GO:0048704 93 0.757
gland development GO:0048732 143 0.752
Zebrafish Mouse
endocrine pancreas development GO:0031018 27 0.744
Zebrafish
cellular component movement GO:0006928 335 0.739
Zebrafish Mouse Fly
regulation of multicellular organismal process GO:0051239 277 0.738
Zebrafish Mouse Worm Fly
sensory organ morphogenesis GO:0090596 200 0.711
Zebrafish Fly
mesenchymal cell development GO:0014031 78 0.710
Mouse
ear development GO:0043583 127 0.704
Zebrafish Mouse
embryo development ending in birth or egg hatching GO:0009792 271 0.703
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.695
cell morphogenesis involved in differentiation GO:0000904 195 0.695
Zebrafish Mouse Fly
forebrain development GO:0030900 96 0.694
peripheral nervous system neuron differentiation GO:0048934 28 0.691
epithelial tube morphogenesis GO:0060562 148 0.672
Zebrafish Mouse
otic vesicle morphogenesis GO:0071600 34 0.665
locomotion GO:0040011 313 0.658
Zebrafish Mouse Worm Fly
brain development GO:0007420 293 0.657
embryonic cranial skeleton morphogenesis GO:0048701 90 0.638
growth GO:0040007 174 0.630
Mouse Worm
gliogenesis GO:0042063 45 0.624
organic substance biosynthetic process GO:1901576 289 0.619
Mouse Fly
ear morphogenesis GO:0042471 64 0.608
maintenance of location GO:0051235 4 0.599
nucleobase containing compound biosynthetic process GO:0034654 205 0.596
Mouse Fly
nucleic acid metabolic process GO:0090304 244 0.584
Mouse Fly
regulation of developmental process GO:0050793 247 0.572
Zebrafish Mouse Worm Fly
heterocycle metabolic process GO:0046483 290 0.568
Mouse Fly
axis specification GO:0009798 43 0.568
Mouse
mesenchyme development GO:0060485 127 0.563
Mouse Fly
otic vesicle development GO:0071599 42 0.563
embryonic organ morphogenesis GO:0048562 274 0.560
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.559
Zebrafish Mouse Fly
organic cyclic compound metabolic process GO:1901360 301 0.550
Mouse Fly
developmental growth GO:0048589 166 0.548
Mouse Worm
cell motility GO:0048870 244 0.544
Mouse Fly
cell morphogenesis GO:0000902 289 0.542
Zebrafish Mouse Fly
negative regulation of biological process GO:0048519 304 0.535
Zebrafish Mouse Fly
angiogenesis GO:0001525 158 0.528
Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.525
Mouse Fly
pancreas development GO:0031016 84 0.522
Zebrafish Mouse
regulation of metabolic process GO:0019222 359 0.522
Zebrafish Mouse Fly
neuron projection guidance GO:0097485 86 0.520
Zebrafish Mouse
positive regulation of biological process GO:0048518 253 0.512
Mouse Worm Fly
retina development in camera type eye GO:0060041 146 0.507
sequestering of calcium ion GO:0051208 3 0.499
nitrogen compound metabolic process GO:0006807 319 0.491
Mouse Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.488
Mouse Fly
epithelial cell differentiation GO:0030855 116 0.487
behavior GO:0007610 74 0.487
neuron projection development GO:0031175 180 0.482
Zebrafish Mouse Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.468
Zebrafish Mouse Fly
cell surface receptor signaling pathway GO:0007166 325 0.466
Zebrafish Mouse Fly
embryonic skeletal system development GO:0048706 97 0.466
mechanoreceptor differentiation GO:0042490 37 0.462
foregut morphogenesis GO:0007440 4 0.460
Zebrafish Mouse
camera type eye morphogenesis GO:0048593 108 0.450
larval development GO:0002164 2 0.449
Worm Fly
inner ear morphogenesis GO:0042472 63 0.449
forebrain generation of neurons GO:0021872 14 0.445
cellular aromatic compound metabolic process GO:0006725 295 0.444
Mouse Fly
cellular macromolecule metabolic process GO:0044260 391 0.436
Mouse Fly
negative regulation of developmental process GO:0051093 65 0.431
Mouse
neural tube patterning GO:0021532 33 0.423
Mouse
axonogenesis GO:0007409 152 0.421
Zebrafish Mouse Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.412
Zebrafish Mouse Fly
embryonic heart tube development GO:0035050 133 0.412
Zebrafish Mouse
regulation of transcription dna templated GO:0006355 213 0.410
Zebrafish Mouse Fly
carbohydrate derivative metabolic process GO:1901135 61 0.409
regulation of biosynthetic process GO:0009889 250 0.408
Zebrafish Mouse Fly
astrocyte differentiation GO:0048708 1 0.401
Mouse
cardiogenic plate morphogenesis GO:0003142 1 0.391
embryonic eye morphogenesis GO:0048048 30 0.389
ventral spinal cord development GO:0021517 35 0.385
Zebrafish Mouse
positive regulation of cellular process GO:0048522 201 0.382
Mouse Fly
regulation of cell communication GO:0010646 232 0.380
Zebrafish Mouse Fly
axon guidance GO:0007411 86 0.376
Zebrafish Mouse
establishment of localization in cell GO:0051649 77 0.370
Mouse Fly
negative regulation of transcription dna templated GO:0045892 45 0.370
Mouse
regulation of biological quality GO:0065008 263 0.369
Zebrafish Mouse
locomotory behavior GO:0007626 34 0.360
stem cell differentiation GO:0048863 117 0.357
Zebrafish Mouse
heart development GO:0007507 313 0.357
regionalization GO:0003002 274 0.356
Zebrafish Mouse Fly
endocrine system development GO:0035270 65 0.338
Zebrafish Mouse
hair cell differentiation GO:0035315 32 0.336
embryonic heart tube morphogenesis GO:0003143 108 0.335
Zebrafish Mouse
otic placode formation GO:0043049 23 0.325
diencephalon development GO:0021536 58 0.322
Zebrafish Mouse
retina morphogenesis in camera type eye GO:0060042 79 0.319
regulation of cellular biosynthetic process GO:0031326 245 0.316
Zebrafish Mouse Fly
regulation of cellular metabolic process GO:0031323 320 0.315
Zebrafish Mouse Fly
fin development GO:0033333 77 0.315
Zebrafish
response to organic substance GO:0010033 153 0.313
Zebrafish Fly
regulation of nervous system development GO:0051960 90 0.311
Mouse
cellular component morphogenesis GO:0032989 336 0.308
Zebrafish Mouse Fly
axon development GO:0061564 166 0.307
Zebrafish Mouse Fly
cellular biosynthetic process GO:0044249 286 0.302
Mouse Fly
somitogenesis GO:0001756 87 0.295
Zebrafish
heart looping GO:0001947 94 0.289
Zebrafish Mouse
thalamus development GO:0021794 6 0.287
Mouse
cell projection organization GO:0030030 284 0.287
Zebrafish Mouse Fly
taxis GO:0042330 109 0.285
Zebrafish Mouse
embryonic camera type eye formation GO:0060900 10 0.285
embryonic camera type eye morphogenesis GO:0048596 19 0.284
negative regulation of cellular process GO:0048523 283 0.283
Zebrafish Mouse Fly
negative regulation of nervous system development GO:0051961 22 0.282
muscle cell differentiation GO:0042692 139 0.279
cell growth GO:0016049 57 0.277
motor neuron axon guidance GO:0008045 23 0.276
regulation of rna metabolic process GO:0051252 224 0.274
Zebrafish Mouse Fly
neural tube development GO:0021915 62 0.271
Zebrafish Mouse
stem cell proliferation GO:0072089 4 0.269
Mouse
aromatic compound biosynthetic process GO:0019438 217 0.266
Mouse Fly
hindbrain development GO:0030902 91 0.262
Zebrafish Mouse
morphogenesis of embryonic epithelium GO:0016331 30 0.260
Zebrafish Mouse
neural crest cell development GO:0014032 62 0.260
Mouse
skeletal system development GO:0001501 181 0.255
transcription dna templated GO:0006351 181 0.255
Mouse Fly
glial cell development GO:0021782 20 0.254
Mouse
blood vessel morphogenesis GO:0048514 216 0.253
Mouse
regulation of primary metabolic process GO:0080090 311 0.253
Zebrafish Mouse Fly
gene expression GO:0010467 252 0.253
Zebrafish Mouse Fly
nucleic acid templated transcription GO:0097659 181 0.252
Mouse Fly
anterior posterior pattern specification GO:0009952 152 0.252
Zebrafish Mouse Fly
cell migration GO:0016477 237 0.250
Mouse Fly
otic vesicle formation GO:0030916 27 0.242
cellular nitrogen compound metabolic process GO:0034641 290 0.240
Mouse Fly
macromolecule biosynthetic process GO:0009059 227 0.235
Mouse Fly
negative regulation of multicellular organismal process GO:0051241 69 0.234
Mouse
epidermal cell differentiation GO:0009913 36 0.233
neuron development GO:0048666 262 0.231
Zebrafish Mouse Fly
biosynthetic process GO:0009058 294 0.230
Mouse Fly
negative regulation of signal transduction GO:0009968 94 0.230
Mouse
negative regulation of response to stimulus GO:0048585 104 0.228
Mouse
developmental growth involved in morphogenesis GO:0060560 86 0.225
Mouse
segmentation GO:0035282 97 0.224
Zebrafish Fly
stem cell development GO:0048864 82 0.214
Mouse
cell fate commitment GO:0045165 99 0.213
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.207
Zebrafish Mouse Fly
convergent extension GO:0060026 118 0.204
adult behavior GO:0030534 2 0.200
regulation of organ morphogenesis GO:2000027 35 0.199
Zebrafish Mouse
stem cell division GO:0017145 1 0.199
negative regulation of cell development GO:0010721 26 0.199
digestive tract development GO:0048565 265 0.198
Zebrafish Mouse Fly
positive regulation of gastrulation GO:2000543 2 0.198
auditory receptor cell fate commitment GO:0009912 4 0.197
mitotic cell cycle process GO:1903047 48 0.195
organonitrogen compound biosynthetic process GO:1901566 47 0.194
blood vessel development GO:0001568 246 0.194
Mouse
digestive system development GO:0055123 289 0.193
Zebrafish Mouse Fly
otolith development GO:0048840 32 0.193
cell cycle GO:0007049 93 0.189
Fly
inner ear development GO:0048839 126 0.189
Zebrafish Mouse
response to external stimulus GO:0009605 264 0.187
Zebrafish Mouse
immune system development GO:0002520 191 0.185
Mouse
regulation of wnt signaling pathway GO:0030111 53 0.184
Mouse
gastrulation GO:0007369 208 0.183
wound healing GO:0042060 90 0.182
Mouse
compound eye development GO:0048749 2 0.181
Fly
forebrain regionalization GO:0021871 4 0.180
Mouse
gastrulation with mouth forming second GO:0001702 44 0.180
midbrain hindbrain boundary development GO:0030917 23 0.179
oligodendrocyte cell fate specification GO:0021778 4 0.179
Zebrafish
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.178
Mouse
negative regulation of wnt signaling pathway GO:0030178 30 0.174
Mouse
negative regulation of neurogenesis GO:0050768 20 0.173
vasculature development GO:0001944 278 0.168
Mouse
developmental cell growth GO:0048588 52 0.165
digestive tract morphogenesis GO:0048546 231 0.165
Zebrafish Mouse Fly
positive regulation of nervous system development GO:0051962 25 0.164
Mouse
endocardium morphogenesis GO:0003160 4 0.163
optic placode formation involved in camera type eye formation GO:0046619 3 0.162
rostrocaudal neural tube patterning GO:0021903 29 0.161
negative regulation of signaling GO:0023057 96 0.161
Mouse
lipid storage GO:0019915 1 0.159
inner ear receptor cell differentiation GO:0060113 29 0.156
muscle structure development GO:0061061 196 0.153
regeneration GO:0031099 91 0.153
transcription from rna polymerase ii promoter GO:0006366 80 0.151
Mouse
neural crest cell differentiation GO:0014033 72 0.151
Mouse
embryonic camera type eye development GO:0031076 29 0.150
Zebrafish
neuroblast proliferation GO:0007405 2 0.150
Mouse
cranial nerve development GO:0021545 42 0.149
single organism behavior GO:0044708 24 0.145
neuron projection extension GO:1990138 45 0.143
regulation of signaling GO:0023051 235 0.141
Zebrafish Mouse Fly
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.139
Mouse
establishment of localization GO:0051234 244 0.139
Mouse Fly
cell migration involved in gastrulation GO:0042074 79 0.139
ameboidal type cell migration GO:0001667 143 0.138
Mouse Fly
endocardium formation GO:0060214 1 0.138
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.137
Zebrafish Mouse Fly
tissue regeneration GO:0042246 74 0.136
peripheral nervous system development GO:0007422 55 0.134
wnt signaling pathway GO:0016055 80 0.130
Mouse
positive regulation of epithelial cell differentiation GO:0030858 2 0.129
axis elongation GO:0003401 31 0.128
Mouse
developmental pigmentation GO:0048066 48 0.128
homeostatic process GO:0042592 142 0.126
Zebrafish
cell cycle process GO:0022402 53 0.126
embryonic pattern specification GO:0009880 44 0.125
Fly
neurological system process GO:0050877 62 0.124
response to abiotic stimulus GO:0009628 122 0.123
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.123
response to stress GO:0006950 263 0.122
Mouse
glial cell differentiation GO:0010001 42 0.121
Zebrafish Mouse
epithelial cell development GO:0002064 42 0.121
striated muscle cell differentiation GO:0051146 129 0.120
regulation of macromolecule metabolic process GO:0060255 317 0.119
Zebrafish Mouse Fly
axon extension GO:0048675 45 0.119
hepatic duct development GO:0061011 2 0.118
regulation of multicellular organism growth GO:0040014 4 0.117
Worm
mesenchymal cell differentiation GO:0048762 87 0.112
Mouse
embryonic limb morphogenesis GO:0030326 2 0.112
Mouse
regulation of growth GO:0040008 42 0.112
Worm
embryonic viscerocranium morphogenesis GO:0048703 52 0.112
hindbrain morphogenesis GO:0021575 22 0.111
regulation of gene expression GO:0010468 265 0.111
Zebrafish Mouse Fly
positive regulation of macromolecule metabolic process GO:0010604 93 0.110
Mouse
single organism localization GO:1902578 225 0.109
Mouse Fly
cellular macromolecule localization GO:0070727 21 0.108
Mouse Fly
oligodendrocyte differentiation GO:0048709 23 0.108
Zebrafish Mouse
response to endogenous stimulus GO:0009719 83 0.106
Fly
chemotaxis GO:0006935 104 0.106
Zebrafish Mouse
regulation of stem cell proliferation GO:0072091 2 0.104
Mouse
neuromast development GO:0048884 46 0.104
nerve development GO:0021675 45 0.103
organonitrogen compound metabolic process GO:1901564 74 0.102
single organism reproductive process GO:0044702 40 0.102
Mouse Fly
system process GO:0003008 185 0.100
Zebrafish
ectodermal placode formation GO:0060788 26 0.099
enzyme linked receptor protein signaling pathway GO:0007167 106 0.099
Zebrafish Fly
regulation of cell development GO:0060284 100 0.099
Mouse
negative regulation of metabolic process GO:0009892 86 0.098
Mouse Fly
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.098
Mouse
optic placode formation GO:0001743 4 0.097
hematopoietic or lymphoid organ development GO:0048534 191 0.096
Mouse
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.094
regulation of protein catabolic process GO:0042176 1 0.094
Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.093
Zebrafish Mouse Fly
regulation of neurogenesis GO:0050767 87 0.092
Mouse
regulation of signal transduction GO:0009966 225 0.092
Zebrafish Mouse Fly
female gonad development GO:0008585 4 0.091
multi organism reproductive process GO:0044703 36 0.089
Fly
regulation of developmental growth GO:0048638 38 0.089
Worm
positive regulation of rna biosynthetic process GO:1902680 57 0.089
Mouse
single organism metabolic process GO:0044710 217 0.088
Mouse
embryonic appendage morphogenesis GO:0035113 30 0.088
Mouse
establishment of protein localization to organelle GO:0072594 4 0.088
Mouse Fly
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.088
somite development GO:0061053 96 0.086
Zebrafish Mouse
regulation of multicellular organismal development GO:2000026 223 0.085
Zebrafish Mouse Fly
nucleobase containing compound metabolic process GO:0006139 274 0.085
Mouse Fly
regulation of rna biosynthetic process GO:2001141 213 0.085
Zebrafish Mouse Fly
connective tissue development GO:0061448 99 0.084
Zebrafish
metencephalon development GO:0022037 27 0.083
cellular response to external stimulus GO:0071496 2 0.079
neuron projection morphogenesis GO:0048812 161 0.079
Zebrafish Mouse Fly
pigment cell differentiation GO:0050931 38 0.078
positive regulation of cellular component biogenesis GO:0044089 3 0.078
regulation of protein transport GO:0051223 3 0.076
Mouse Fly
skin development GO:0043588 54 0.076
Mouse
regulation of response to stimulus GO:0048583 269 0.076
Zebrafish Mouse Fly
inner ear receptor cell development GO:0060119 20 0.075
positive regulation of rna metabolic process GO:0051254 59 0.074
Mouse
smoothened signaling pathway GO:0007224 30 0.074
Zebrafish Mouse Fly
dorsal ventral axis specification GO:0009950 14 0.074
morphogenesis of an epithelial sheet GO:0002011 49 0.073
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.073
Zebrafish Mouse
positive regulation of developmental process GO:0051094 50 0.073
Mouse Worm
development of primary female sexual characteristics GO:0046545 4 0.073
peripheral nervous system neuron development GO:0048935 22 0.073
lymphocyte differentiation GO:0030098 9 0.072
Mouse
dendrite morphogenesis GO:0048813 5 0.070
hepaticobiliary system development GO:0061008 98 0.070
nucleocytoplasmic transport GO:0006913 4 0.070
Mouse Fly
cell part morphogenesis GO:0032990 246 0.070
Zebrafish Mouse Fly
lateral line system development GO:0048925 76 0.069
forebrain neuron differentiation GO:0021879 14 0.069
regulation of heart morphogenesis GO:2000826 17 0.068
Zebrafish
protein metabolic process GO:0019538 183 0.068
Mouse Fly
programmed cell death GO:0012501 119 0.068
Mouse
ectodermal placode development GO:0071696 37 0.068
pectoral fin development GO:0033339 50 0.068
Zebrafish
negative regulation of gene expression GO:0010629 65 0.068
Mouse Fly
epidermis development GO:0008544 48 0.067
Mouse
cell death GO:0008219 121 0.067
Mouse
regulation of anatomical structure morphogenesis GO:0022603 130 0.067
Zebrafish Mouse
positive regulation of embryonic development GO:0040019 3 0.067
signal transduction GO:0007165 455 0.067
Zebrafish Mouse Fly
cell proliferation in forebrain GO:0021846 3 0.066
positive regulation of stem cell proliferation GO:2000648 1 0.065
Mouse
ventricular system development GO:0021591 12 0.065
neuron fate commitment GO:0048663 26 0.064
intracellular receptor signaling pathway GO:0030522 30 0.064
liver development GO:0001889 96 0.064
negative regulation of nucleic acid templated transcription GO:1903507 45 0.063
Mouse
striated muscle cell proliferation GO:0014855 7 0.062
Mouse
endodermal cell fate determination GO:0007493 2 0.062
mesoderm development GO:0007498 88 0.061
Mouse Fly
regulation of canonical wnt signaling pathway GO:0060828 34 0.061
Mouse
common bile duct development GO:0061009 13 0.061
pituitary gland development GO:0021983 16 0.061
Zebrafish
cell proliferation GO:0008283 80 0.061
Zebrafish Mouse
inner ear receptor cell fate commitment GO:0060120 4 0.059
regulation of epithelial cell proliferation GO:0050678 3 0.058
Mouse
cell differentiation in spinal cord GO:0021515 40 0.058
Zebrafish Mouse
epithelial to mesenchymal transition GO:0001837 21 0.057
positive regulation of cellular biosynthetic process GO:0031328 68 0.057
Mouse
response to wounding GO:0009611 116 0.057
Mouse
pectoral fin morphogenesis GO:0035138 29 0.056
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.055
Mouse
embryonic foregut morphogenesis GO:0048617 1 0.054
Mouse
positive regulation of cell cycle GO:0045787 3 0.053
retina layer formation GO:0010842 24 0.053
dorsal convergence GO:0060030 14 0.053
heart formation GO:0060914 13 0.053
Fly
developmental process involved in reproduction GO:0003006 27 0.053
Mouse Fly
single organism nuclear import GO:1902593 3 0.052
Mouse Fly
cell migration involved in heart development GO:0060973 22 0.052
proepicardium development GO:0003342 4 0.052
negative regulation of biosynthetic process GO:0009890 55 0.052
Mouse
posterior lateral line neuromast hair cell differentiation GO:0048923 8 0.052
stem cell maintenance GO:0019827 4 0.052
fin morphogenesis GO:0033334 53 0.051
Zebrafish
appendage development GO:0048736 80 0.051
Zebrafish Mouse
negative regulation of apoptotic process GO:0043066 55 0.051
Mouse
convergent extension involved in gastrulation GO:0060027 71 0.051
regulation of jun kinase activity GO:0043506 3 0.050
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.050
Zebrafish
forebrain anterior posterior pattern specification GO:0021797 3 0.050
regulation of localization GO:0032879 104 0.049
Mouse Fly
regulation of transport GO:0051049 45 0.049
Mouse Fly
neural crest cell migration GO:0001755 42 0.049
Mouse
negative regulation of cell differentiation GO:0045596 46 0.048
Mouse
positive regulation of catabolic process GO:0009896 4 0.048
negative regulation of cellular metabolic process GO:0031324 77 0.047
Mouse Fly
regulation of glial cell differentiation GO:0045685 4 0.047
Mouse
mesodermal cell differentiation GO:0048333 21 0.046
extrinsic apoptotic signaling pathway GO:0097191 3 0.046
type b pancreatic cell development GO:0003323 4 0.046
organelle organization GO:0006996 227 0.046
Mouse
macromolecule localization GO:0033036 54 0.045
Mouse Fly
negative regulation of rna biosynthetic process GO:1902679 45 0.045
Mouse
septum transversum development GO:0003343 4 0.044
small molecule metabolic process GO:0044281 77 0.044
multicellular organismal reproductive process GO:0048609 35 0.044
Fly
central nervous system myelin formation GO:0032289 1 0.044
exocrine system development GO:0035272 28 0.043
Mouse
auditory receptor cell differentiation GO:0042491 15 0.043
regulation of molecular function GO:0065009 70 0.043
Mouse Fly
cartilage development GO:0051216 96 0.043
Zebrafish
multicellular organism reproduction GO:0032504 35 0.043
Fly
endocardium development GO:0003157 9 0.043
apoptotic process GO:0006915 116 0.042
Mouse
intracellular signal transduction GO:0035556 85 0.042
Mouse Fly
positive regulation of gene expression GO:0010628 71 0.042
Mouse
regulation of cell cycle GO:0051726 52 0.042
Fly
spinal cord radial glial cell differentiation GO:0021531 2 0.042
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.042
cellular component biogenesis GO:0044085 178 0.042
Fly
somatic stem cell maintenance GO:0035019 1 0.042
regulation of apoptotic process GO:0042981 98 0.042
Mouse
appendage morphogenesis GO:0035107 56 0.041
Zebrafish Mouse
regulation of cellular component organization GO:0051128 86 0.041
endoderm development GO:0007492 49 0.041
facial nucleus development GO:0021754 7 0.041
negative regulation of cell communication GO:0010648 96 0.041
Mouse
ribose phosphate metabolic process GO:0019693 27 0.041
positive regulation of transcription dna templated GO:0045893 57 0.041
Mouse
forebrain neuron development GO:0021884 7 0.040
protein localization to nucleus GO:0034504 3 0.040
Mouse Fly
negative regulation of rna metabolic process GO:0051253 48 0.040
Mouse
cell cell signaling GO:0007267 52 0.040
Mouse Fly
immune system process GO:0002376 241 0.038
Mouse
secondary metabolic process GO:0019748 3 0.038
negative regulation of phosphate metabolic process GO:0045936 13 0.038
negative regulation of muscle tissue development GO:1901862 2 0.038
Mouse
rna metabolic process GO:0016070 219 0.038
Mouse Fly
axonal fasciculation GO:0007413 11 0.038
positive regulation of metabolic process GO:0009893 108 0.038
Mouse
death GO:0016265 121 0.037
Mouse
cardiocyte differentiation GO:0035051 44 0.037
cellular macromolecule biosynthetic process GO:0034645 224 0.037
Mouse Fly
neural retina development GO:0003407 49 0.037
dorsal ventral neural tube patterning GO:0021904 1 0.037
Mouse
spinal cord oligodendrocyte cell differentiation GO:0021529 5 0.036
Zebrafish
regulation of cell growth GO:0001558 29 0.036
cellular protein modification process GO:0006464 100 0.036
Fly
embryonic epithelial tube formation GO:0001838 17 0.036
cellular component assembly GO:0022607 170 0.036
Fly
cell projection morphogenesis GO:0048858 244 0.036
Zebrafish Mouse Fly
hemopoiesis GO:0030097 183 0.035
Mouse
neuron fate determination GO:0048664 2 0.035
regulation of axonogenesis GO:0050770 32 0.035
regulation of sequestering of calcium ion GO:0051282 4 0.035
epithelial cell fate commitment GO:0072148 11 0.034
neural precursor cell proliferation GO:0061351 20 0.034
Mouse
semicircular canal development GO:0060872 24 0.034
carbohydrate derivative biosynthetic process GO:1901137 43 0.034
gall bladder development GO:0061010 1 0.034
epidermal cell fate specification GO:0009957 4 0.034
positive regulation of biosynthetic process GO:0009891 68 0.034
Mouse
growth plate cartilage development GO:0003417 2 0.034
anterior posterior axis specification GO:0009948 20 0.033
Mouse
fourth ventricle development GO:0021592 8 0.033
response to alkaloid GO:0043279 2 0.033
skeletal system morphogenesis GO:0048705 102 0.033
determination of digestive tract left right asymmetry GO:0071907 10 0.033
embryonic neurocranium morphogenesis GO:0048702 15 0.033
regulation of transcription involved in cell fate commitment GO:0060850 1 0.033
notochord development GO:0030903 54 0.032
spinal cord development GO:0021510 46 0.032
Zebrafish Mouse
optic cup morphogenesis involved in camera type eye development GO:0002072 7 0.032
catabolic process GO:0009056 32 0.032
Mouse
cardiac muscle tissue development GO:0048738 48 0.032
heart jogging GO:0003146 40 0.032
Zebrafish
nucleoside phosphate metabolic process GO:0006753 28 0.032
myeloid cell differentiation GO:0030099 86 0.031
pigmentation GO:0043473 85 0.031
single organism transport GO:0044765 206 0.031
Mouse Fly
regulation of epithelial to mesenchymal transition GO:0010717 3 0.031
closure of optic fissure GO:0061386 6 0.031
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.031
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.031
Zebrafish
cation transport GO:0006812 81 0.031
endodermal digestive tract morphogenesis GO:0061031 2 0.031
bmp signaling pathway involved in heart development GO:0061312 15 0.030
Zebrafish
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.030
Mouse
iridophore differentiation GO:0050935 9 0.030
apoptotic signaling pathway GO:0097190 23 0.030
Mouse
regulation of programmed cell death GO:0043067 101 0.029
Mouse
ectodermal placode morphogenesis GO:0071697 32 0.029
negative regulation of cellular component movement GO:0051271 18 0.029
Mouse
single organism organelle organization GO:1902589 199 0.029
Mouse
dorsal ventral pattern formation GO:0009953 125 0.028
Zebrafish Mouse
retinoic acid receptor signaling pathway GO:0048384 16 0.028
regulation of establishment of protein localization GO:0070201 4 0.028
Mouse Fly
regulation of inner ear receptor cell differentiation GO:2000980 1 0.028
anterior head development GO:0097065 2 0.028
mesenchymal cell proliferation GO:0010463 1 0.028
Mouse
phosphorus metabolic process GO:0006793 109 0.028
regulation of tube size GO:0035150 2 0.027
positive regulation of neurogenesis GO:0050769 24 0.027
Mouse
microtubule based process GO:0007017 60 0.026
positive regulation of multicellular organismal process GO:0051240 52 0.025
Mouse Worm
swim bladder development GO:0048794 19 0.025
Zebrafish
embryonic heart tube formation GO:0003144 1 0.025
organophosphate metabolic process GO:0019637 37 0.025
regulation of cartilage development GO:0061035 7 0.025
Zebrafish
phosphate containing compound metabolic process GO:0006796 108 0.025
epiboly GO:0090504 41 0.024
purine containing compound metabolic process GO:0072521 29 0.024
sensory system development GO:0048880 76 0.024
limbic system development GO:0021761 16 0.024
neuron fate specification GO:0048665 20 0.023
Zebrafish
single organism biosynthetic process GO:0044711 71 0.023
regulation of cell proliferation GO:0042127 37 0.023
Zebrafish Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.023
Mouse
renal tubule morphogenesis GO:0061333 1 0.023
Mouse
polarized epithelial cell differentiation GO:0030859 4 0.023
negative regulation of programmed cell death GO:0043069 58 0.023
Mouse
positive regulation of response to stimulus GO:0048584 80 0.023
Mouse Fly
nuclear transport GO:0051169 4 0.022
Mouse Fly
nucleotide metabolic process GO:0009117 28 0.022
positive regulation of cellular metabolic process GO:0031325 94 0.022
Mouse
negative regulation of cell death GO:0060548 60 0.022
Mouse

shhb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.336
bone development disease DOID:0080006 0 0.027
bone disease DOID:0080001 0 0.027
musculoskeletal system disease DOID:17 0 0.027
connective tissue disease DOID:65 0 0.027
osteochondrodysplasia DOID:2256 0 0.024