Danio rerio

67 known processes

six1b

sine oculis homeobox homolog 1b

(Aliases: zgc:77345,MGC77345,six1)

six1b biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.999
Human Zebrafish Mouse Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.998
Human Zebrafish Mouse Fly
organic substance biosynthetic process GO:1901576 289 0.990
Human Zebrafish Mouse Fly
regulation of metabolic process GO:0019222 359 0.988
Human Zebrafish Mouse Fly
rna biosynthetic process GO:0032774 181 0.960
Human Zebrafish Mouse Fly
central nervous system development GO:0007417 387 0.958
cellular aromatic compound metabolic process GO:0006725 295 0.956
Human Zebrafish Mouse Fly
striated muscle cell differentiation GO:0051146 129 0.951
nucleobase containing compound biosynthetic process GO:0034654 205 0.950
Human Zebrafish Mouse Fly
regulation of gene expression GO:0010468 265 0.933
Human Zebrafish Mouse Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.926
Human Zebrafish Mouse Fly
regulation of biosynthetic process GO:0009889 250 0.918
Human Zebrafish Mouse Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.915
Human Zebrafish Mouse Fly
macromolecule biosynthetic process GO:0009059 227 0.904
Human Zebrafish Mouse Fly
inner ear development GO:0048839 126 0.903
nucleic acid templated transcription GO:0097659 181 0.877
Human Zebrafish Mouse Fly
generation of neurons GO:0048699 385 0.865
regulation of mechanoreceptor differentiation GO:0045631 1 0.850
Zebrafish
regulation of rna metabolic process GO:0051252 224 0.849
Human Zebrafish Mouse Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.840
Human Zebrafish Mouse Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.838
Human Zebrafish Mouse Fly
regulation of cellular metabolic process GO:0031323 320 0.837
Human Zebrafish Mouse Fly
localization of cell GO:0051674 244 0.835
Mouse Fly
organic cyclic compound metabolic process GO:1901360 301 0.830
Human Zebrafish Mouse Fly
posterior lateral line system development GO:0048915 46 0.817
somatic muscle development GO:0007525 4 0.812
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.801
Human Mouse Fly
cellular biosynthetic process GO:0044249 286 0.799
Human Zebrafish Mouse Fly
muscle contraction GO:0006936 18 0.796
biosynthetic process GO:0009058 294 0.795
Human Zebrafish Mouse Fly
aromatic compound biosynthetic process GO:0019438 217 0.787
Human Zebrafish Mouse Fly
pharyngeal muscle development GO:0043282 4 0.778
heterocycle biosynthetic process GO:0018130 215 0.758
Human Zebrafish Mouse Fly
nitrogen compound metabolic process GO:0006807 319 0.752
Human Zebrafish Mouse Fly
regulation of rna biosynthetic process GO:2001141 213 0.749
Human Zebrafish Mouse Fly
neuron development GO:0048666 262 0.742
regulation of cellular biosynthetic process GO:0031326 245 0.734
Human Zebrafish Mouse Fly
heterocycle metabolic process GO:0046483 290 0.718
Human Zebrafish Mouse Fly
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.713
Mouse
positive regulation of cellular biosynthetic process GO:0031328 68 0.696
Human Mouse Fly
cellular macromolecule metabolic process GO:0044260 391 0.676
Human Zebrafish Mouse Fly
endocrine system development GO:0035270 65 0.668
muscle tissue development GO:0060537 110 0.660
cellular macromolecule biosynthetic process GO:0034645 224 0.629
Human Zebrafish Mouse Fly
skeletal muscle organ development GO:0060538 78 0.624
myotube differentiation GO:0014902 45 0.619
embryo development ending in birth or egg hatching GO:0009792 271 0.611
Mouse
chemotaxis GO:0006935 104 0.601
regulation of stem cell proliferation GO:0072091 2 0.596
Mouse
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 1 0.568
gene expression GO:0010467 252 0.567
Human Zebrafish Mouse Fly
larval development GO:0002164 2 0.567
cellular component movement GO:0006928 335 0.555
Mouse Fly
hair cell differentiation GO:0035315 32 0.523
posterior lateral line development GO:0048916 38 0.522
posterior lateral line neuromast development GO:0048919 20 0.498
neuron projection development GO:0031175 180 0.494
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.487
Human Mouse Fly
regulation of neuron migration GO:2001222 2 0.480
pituitary gland development GO:0021983 16 0.479
somitogenesis GO:0001756 87 0.479
mechanosensory lateral line system development GO:0048881 49 0.464
reproductive process GO:0022414 40 0.461
Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.456
Human Zebrafish Mouse Fly
striated muscle myosin thick filament assembly GO:0071688 6 0.442
forebrain development GO:0030900 96 0.438
atp catabolic process GO:0006200 4 0.428
muscle cell development GO:0055001 115 0.423
axon development GO:0061564 166 0.421
transcription from rna polymerase ii promoter GO:0006366 80 0.417
Human Zebrafish Mouse Fly
muscle structure development GO:0061061 196 0.415
transcription dna templated GO:0006351 181 0.415
Human Zebrafish Mouse Fly
regulation of primary metabolic process GO:0080090 311 0.415
Human Zebrafish Mouse Fly
autonomic nervous system development GO:0048483 19 0.413
Mouse
regulation of vitamin metabolic process GO:0030656 6 0.399
muscle system process GO:0003012 20 0.391
nucleobase containing compound metabolic process GO:0006139 274 0.391
Human Zebrafish Mouse Fly
neuron projection guidance GO:0097485 86 0.384
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.375
skeletal muscle thin filament assembly GO:0030240 4 0.372
heart morphogenesis GO:0003007 156 0.367
Mouse
sensory organ development GO:0007423 393 0.359
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.355
extraocular skeletal muscle development GO:0002074 3 0.352
lateral line development GO:0048882 66 0.351
ameboidal type cell migration GO:0001667 143 0.338
cell migration GO:0016477 237 0.334
Mouse Fly
rna metabolic process GO:0016070 219 0.318
Human Zebrafish Mouse Fly
epithelial cell differentiation GO:0030855 116 0.314
Mouse
sensory system development GO:0048880 76 0.299
auditory receptor cell fate commitment GO:0009912 4 0.297
positive regulation of cellular process GO:0048522 201 0.286
Human Mouse Fly
nucleic acid metabolic process GO:0090304 244 0.273
Human Zebrafish Mouse Fly
chordate embryonic development GO:0043009 271 0.271
Mouse
cellular component morphogenesis GO:0032989 336 0.269
stem cell proliferation GO:0072089 4 0.266
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.258
positive regulation of rna metabolic process GO:0051254 59 0.257
Human Mouse Fly
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.256
myotube cell development GO:0014904 35 0.255
cell fate commitment GO:0045165 99 0.255
Mouse
regulation of inner ear receptor cell differentiation GO:2000980 1 0.248
Zebrafish
small molecule metabolic process GO:0044281 77 0.243
signal transduction GO:0007165 455 0.243
regulation of neuron differentiation GO:0045664 56 0.242
Zebrafish Mouse
adenohypophysis development GO:0021984 15 0.238
pigment cell development GO:0070285 3 0.230
positive regulation of rna biosynthetic process GO:1902680 57 0.229
Human Mouse Fly
positive regulation of biological process GO:0048518 253 0.225
Human Mouse Fly
regulation of chemotaxis GO:0050920 18 0.225
positive regulation of metabolic process GO:0009893 108 0.221
Human Mouse Fly
multicellular organism reproduction GO:0032504 35 0.218
Fly
nephron morphogenesis GO:0072028 2 0.215
Mouse
neuromast development GO:0048884 46 0.214
actin filament organization GO:0007015 15 0.213
diencephalon development GO:0021536 58 0.210
retina development in camera type eye GO:0060041 146 0.208
axon guidance GO:0007411 86 0.207
organelle localization GO:0051640 49 0.204
positive regulation of notch signaling pathway GO:0045747 3 0.202
cell migration in hindbrain GO:0021535 7 0.202
myofibril assembly GO:0030239 48 0.202
regulation of epithelial cell proliferation GO:0050678 3 0.194
Mouse
locomotion GO:0040011 313 0.188
Mouse Fly
innervation GO:0060384 3 0.188
regionalization GO:0003002 274 0.187
Mouse
cell proliferation GO:0008283 80 0.185
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.185
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.184
axonal fasciculation GO:0007413 11 0.182
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.181
posterior lateral line neuromast hair cell differentiation GO:0048923 8 0.180
ribonucleoside monophosphate catabolic process GO:0009158 4 0.175
behavior GO:0007610 74 0.173
embryonic organ morphogenesis GO:0048562 274 0.172
Zebrafish Mouse
regulation of collateral sprouting GO:0048670 7 0.172
muscle fiber development GO:0048747 52 0.170
venous blood vessel development GO:0060841 9 0.169
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.168
Mouse
otolith development GO:0048840 32 0.165
regulation of macromolecule metabolic process GO:0060255 317 0.164
Human Zebrafish Mouse Fly
canonical wnt signaling pathway GO:0060070 48 0.163
muscle organ development GO:0007517 101 0.162
embryonic epithelial tube formation GO:0001838 17 0.161
Mouse
mechanoreceptor differentiation GO:0042490 37 0.155
Zebrafish
positive regulation of biosynthetic process GO:0009891 68 0.154
Human Mouse Fly
cell projection organization GO:0030030 284 0.150
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.150
fin development GO:0033333 77 0.149
regulation of cell development GO:0060284 100 0.149
Zebrafish Mouse
central nervous system neuron differentiation GO:0021953 74 0.147
neuroblast proliferation GO:0007405 2 0.144
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.143
purine nucleoside monophosphate catabolic process GO:0009128 4 0.143
muscle cell differentiation GO:0042692 139 0.142
cell morphogenesis GO:0000902 289 0.142
positive regulation of nucleic acid templated transcription GO:1903508 57 0.139
Human Mouse Fly
organonitrogen compound metabolic process GO:1901564 74 0.139
epidermal cell differentiation GO:0009913 36 0.138
positive regulation of transcription dna templated GO:0045893 57 0.138
Human Mouse Fly
regulation of neurogenesis GO:0050767 87 0.137
Zebrafish Mouse
extrinsic apoptotic signaling pathway GO:0097191 3 0.137
cell morphogenesis involved in differentiation GO:0000904 195 0.135
skin development GO:0043588 54 0.135
positive regulation of stem cell proliferation GO:2000648 1 0.135
Mouse
multicellular organismal reproductive process GO:0048609 35 0.134
Fly
collateral sprouting GO:0048668 9 0.134
photoreceptor cell fate specification GO:0043704 1 0.134
brain development GO:0007420 293 0.133
cell cycle process GO:0022402 53 0.132
positive regulation of cell proliferation GO:0008284 15 0.132
Mouse
axonogenesis GO:0007409 152 0.131
venous blood vessel morphogenesis GO:0048845 3 0.131
embryonic organ development GO:0048568 381 0.131
Zebrafish Mouse
signal transduction in absence of ligand GO:0038034 1 0.130
peripheral nervous system development GO:0007422 55 0.127
divalent inorganic cation transport GO:0072511 21 0.126
neural crest cell migration GO:0001755 42 0.122
regulation of anatomical structure morphogenesis GO:0022603 130 0.119
Mouse
neuron differentiation GO:0030182 353 0.117
somite specification GO:0001757 12 0.117
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.116
Human Mouse Fly
pharynx development GO:0060465 5 0.114
regulation of heart growth GO:0060420 2 0.113
regulation of nucleic acid templated transcription GO:1903506 213 0.110
Human Zebrafish Mouse Fly
regulation of retinoic acid biosynthetic process GO:1900052 6 0.108
nephron tubule morphogenesis GO:0072078 1 0.106
Mouse
segment specification GO:0007379 12 0.105
digestive tract development GO:0048565 265 0.105
regulation of muscle contraction GO:0006937 3 0.102
digestive system development GO:0055123 289 0.102
sensory organ morphogenesis GO:0090596 200 0.102
Zebrafish Mouse Fly
lateral line system development GO:0048925 76 0.101
calcium ion transport GO:0006816 18 0.099
neuron recognition GO:0008038 18 0.099
face development GO:0060324 8 0.096
cellular response to retinoic acid GO:0071300 1 0.094
preganglionic parasympathetic nervous system development GO:0021783 6 0.094
Mouse
nucleoside monophosphate catabolic process GO:0009125 4 0.092
neuromuscular process controlling balance GO:0050885 3 0.090
mesodermal cell fate commitment GO:0001710 14 0.089
ossification GO:0001503 23 0.087
radial glial cell differentiation GO:0060019 2 0.086
aorta morphogenesis GO:0035909 3 0.085
Mouse
otic vesicle development GO:0071599 42 0.083
Mouse
skeletal muscle tissue development GO:0007519 67 0.083
release of sequestered calcium ion into cytosol GO:0051209 3 0.082
regulation of transcription dna templated GO:0006355 213 0.082
Human Zebrafish Mouse Fly
morphogenesis of an epithelium GO:0002009 333 0.082
Mouse
regulation of response to stimulus GO:0048583 269 0.081
cell surface receptor signaling pathway GO:0007166 325 0.081
negative regulation of wnt signaling pathway GO:0030178 30 0.081
inner ear receptor cell fate commitment GO:0060120 4 0.079
cell motility GO:0048870 244 0.079
Mouse Fly
aorta development GO:0035904 4 0.079
Mouse
establishment or maintenance of cell polarity GO:0007163 29 0.078
post embryonic organ development GO:0048569 4 0.077
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.074
inner ear morphogenesis GO:0042472 63 0.073
Mouse
phosphorus metabolic process GO:0006793 109 0.072
fin morphogenesis GO:0033334 53 0.072
regulation of developmental process GO:0050793 247 0.072
Zebrafish Mouse
negative regulation of cellular process GO:0048523 283 0.069
Mouse
regulation of purine nucleotide catabolic process GO:0033121 2 0.069
spinal cord development GO:0021510 46 0.068
anatomical structure homeostasis GO:0060249 36 0.067
epidermis development GO:0008544 48 0.066
camera type eye morphogenesis GO:0048593 108 0.066
Zebrafish
olfactory placode morphogenesis GO:0071699 7 0.065
Mouse
regulation of organ growth GO:0046620 3 0.065
mesoderm development GO:0007498 88 0.065
negative regulation of macromolecule metabolic process GO:0010605 76 0.064
Mouse
cellular ion homeostasis GO:0006873 17 0.063
divalent metal ion transport GO:0070838 20 0.063
striated muscle cell development GO:0055002 108 0.062
retinal rod cell development GO:0046548 4 0.062
body morphogenesis GO:0010171 16 0.061
regulation of retina development in camera type eye GO:1902866 2 0.061
nephron epithelium morphogenesis GO:0072088 1 0.061
Mouse
regulation of canonical wnt signaling pathway GO:0060828 34 0.061
regulation of nucleoside metabolic process GO:0009118 2 0.060
epithelial tube formation GO:0072175 19 0.059
Mouse
actin cytoskeleton organization GO:0030036 63 0.059
midbrain development GO:0030901 28 0.058
central nervous system myelination GO:0022010 2 0.058
auditory receptor cell development GO:0060117 8 0.057
glial cell fate determination GO:0007403 1 0.056
positive regulation of gene expression GO:0010628 71 0.056
Human Mouse Fly
single organism organelle organization GO:1902589 199 0.056
regulation of heart contraction GO:0008016 32 0.056
mesodermal cell fate specification GO:0007501 12 0.055
immune system process GO:0002376 241 0.055
Mouse
neuromast hair cell differentiation GO:0048886 12 0.055
embryonic viscerocranium morphogenesis GO:0048703 52 0.054
apoptotic process GO:0006915 116 0.054
Mouse
anterior posterior pattern specification GO:0009952 152 0.054
dorsal ventral pattern formation GO:0009953 125 0.053
cell recognition GO:0008037 19 0.053
response to mechanical stimulus GO:0009612 24 0.053
peripheral nervous system neuron differentiation GO:0048934 28 0.052
positive regulation of cellular metabolic process GO:0031325 94 0.052
Human Mouse Fly
cerebellar granular layer formation GO:0021684 3 0.052
multi organism process GO:0051704 134 0.052
Fly
xanthophore differentiation GO:0050936 3 0.052
multicellular organism growth GO:0035264 4 0.051
skeletal system morphogenesis GO:0048705 102 0.051
Mouse
notch signaling pathway GO:0007219 35 0.051
glial cell migration GO:0008347 3 0.050
Fly
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.050
negative regulation of biological process GO:0048519 304 0.050
Mouse
regulation of mesodermal cell fate specification GO:0042661 9 0.050
cellular amino acid metabolic process GO:0006520 7 0.050
developmental programmed cell death GO:0010623 4 0.048
epithelial tube morphogenesis GO:0060562 148 0.048
Mouse
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.047
Mouse
i kappab phosphorylation GO:0007252 1 0.047
neuronal stem cell maintenance GO:0097150 2 0.047
cellular component assembly involved in morphogenesis GO:0010927 107 0.047
cytoskeleton organization GO:0007010 96 0.047
primary neural tube formation GO:0014020 1 0.046
smooth muscle contraction GO:0006939 2 0.045
cell proliferation involved in heart morphogenesis GO:0061323 2 0.045
Mouse
innate immune response GO:0045087 13 0.045
gastrulation GO:0007369 208 0.044
nucleotide metabolic process GO:0009117 28 0.044
blood vessel development GO:0001568 246 0.044
Mouse
establishment of cell polarity GO:0030010 18 0.043
development of primary female sexual characteristics GO:0046545 4 0.043
homeostatic process GO:0042592 142 0.043
positive regulation of cell fate commitment GO:0010455 1 0.042
regulation of multicellular organismal development GO:2000026 223 0.042
Zebrafish Mouse
response to stress GO:0006950 263 0.042
Zebrafish
morphogenesis of an epithelial sheet GO:0002011 49 0.039
ear development GO:0043583 127 0.039
detection of chemical stimulus GO:0009593 4 0.039
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.038
Mouse
peptidyl tyrosine dephosphorylation GO:0035335 1 0.038
sprouting angiogenesis GO:0002040 53 0.038
appendage development GO:0048736 80 0.038
cell migration involved in gastrulation GO:0042074 79 0.038
embryonic cranial skeleton morphogenesis GO:0048701 90 0.038
Mouse
cation transport GO:0006812 81 0.037
regulation of sarcomere organization GO:0060297 2 0.037
microtubule based process GO:0007017 60 0.037
camera type eye development GO:0043010 222 0.037
gabaergic neuron differentiation GO:0097154 2 0.037
myosin filament organization GO:0031033 6 0.036
skeletal muscle fiber development GO:0048741 35 0.035
retinoic acid biosynthetic process GO:0002138 6 0.035
positive regulation of neurogenesis GO:0050769 24 0.035
negative regulation of axon guidance GO:1902668 1 0.035
transmission of nerve impulse GO:0019226 19 0.035
kidney morphogenesis GO:0060993 15 0.034
Mouse
proepicardium development GO:0003342 4 0.034
actin filament based process GO:0030029 64 0.034
morphogenesis of a branching structure GO:0001763 21 0.034
Mouse
tongue morphogenesis GO:0043587 3 0.034
Mouse
oxoacid metabolic process GO:0043436 31 0.034
somite development GO:0061053 96 0.034
Mouse
skeletal myofibril assembly GO:0014866 7 0.034
biological adhesion GO:0022610 40 0.033
regulation of biological quality GO:0065008 263 0.033
Mouse
regulation of epidermis development GO:0045682 2 0.033
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.033
striated muscle tissue development GO:0014706 110 0.033
striated muscle cell proliferation GO:0014855 7 0.033
proximal distal pattern formation GO:0009954 1 0.033
axon regeneration GO:0031103 14 0.033
negative regulation of developmental process GO:0051093 65 0.032
Mouse
programmed cell death GO:0012501 119 0.032
Mouse
taxis GO:0042330 109 0.032
epidermal cell fate specification GO:0009957 4 0.032
forebrain generation of neurons GO:0021872 14 0.032
regulation of nucleotide catabolic process GO:0030811 2 0.032
cardiac atrium development GO:0003230 4 0.032
angiogenesis GO:0001525 158 0.032
detection of mechanical stimulus GO:0050982 11 0.032
sympathetic ganglion development GO:0061549 2 0.031
muscle cell migration GO:0014812 4 0.031
Mouse
wnt signaling pathway GO:0016055 80 0.031
neuron migration GO:0001764 22 0.031
regulation of hydrolase activity GO:0051336 28 0.031
cytokinesis GO:0000910 3 0.031
cardiac muscle tissue morphogenesis GO:0055008 7 0.030
retinoic acid metabolic process GO:0042573 9 0.030
regulation of calcium ion transport GO:0051924 2 0.030
regulation of cellular component movement GO:0051270 55 0.030
vasculature development GO:0001944 278 0.030
Mouse
chemical homeostasis GO:0048878 49 0.029
embryonic skeletal system development GO:0048706 97 0.029
Mouse
retina morphogenesis in camera type eye GO:0060042 79 0.029
neural retina development GO:0003407 49 0.029
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.029
regulation of locomotion GO:0040012 55 0.028
negative regulation of signal transduction GO:0009968 94 0.028
organic cyclic compound catabolic process GO:1901361 15 0.028
system process GO:0003008 185 0.028
Mouse
head development GO:0060322 303 0.028
neuromast deposition GO:0048885 9 0.028
response to axon injury GO:0048678 14 0.027
response to chemical GO:0042221 320 0.027
regulation of axon extension GO:0030516 24 0.027
stem cell fate determination GO:0048867 1 0.027
negative regulation of chemotaxis GO:0050922 4 0.026
neuroblast differentiation GO:0014016 1 0.026
regulation of cellular amino acid metabolic process GO:0006521 0 0.026
regulation of nervous system development GO:0051960 90 0.026
Zebrafish Mouse
apoptotic process involved in morphogenesis GO:0060561 2 0.026
cytosolic calcium ion transport GO:0060401 3 0.026
homeostasis of number of cells GO:0048872 62 0.026
mitotic cell cycle GO:0000278 64 0.025
regulation of mesoderm development GO:2000380 11 0.025
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 1 0.025
positive regulation of developmental process GO:0051094 50 0.025
Mouse
sensory perception GO:0007600 39 0.025
Mouse
regulation of cell migration GO:0030334 40 0.025
embryonic skeletal system morphogenesis GO:0048704 93 0.025
Mouse
cerebellar granule cell differentiation GO:0021707 3 0.024
negative regulation of cell communication GO:0010648 96 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.024
Human Zebrafish Mouse Fly
carbohydrate derivative metabolic process GO:1901135 61 0.023
alcohol biosynthetic process GO:0046165 2 0.023
cerebellar granular layer morphogenesis GO:0021683 3 0.023
regulation of notch signaling pathway GO:0008593 16 0.023
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.023
hindbrain development GO:0030902 91 0.022
embryonic eye morphogenesis GO:0048048 30 0.022
Zebrafish
regulation of axonogenesis GO:0050770 32 0.022
regulation of phosphate metabolic process GO:0019220 43 0.022
auditory receptor cell differentiation GO:0042491 15 0.022
septum transversum development GO:0003343 4 0.022
embryonic heart tube development GO:0035050 133 0.022
cell differentiation in spinal cord GO:0021515 40 0.022
neuron fate specification GO:0048665 20 0.022
Mouse
diterpenoid biosynthetic process GO:0016102 7 0.022
gtp catabolic process GO:0006184 2 0.021
regulation of cell differentiation GO:0045595 142 0.021
Zebrafish Mouse
lamellipodium assembly GO:0030032 1 0.021
atp metabolic process GO:0046034 5 0.021
digestive tract morphogenesis GO:0048546 231 0.021
response to activity GO:0014823 14 0.021
negative regulation of biosynthetic process GO:0009890 55 0.020
Mouse
neural crest cell development GO:0014032 62 0.020
melanin metabolic process GO:0006582 2 0.020
response to wounding GO:0009611 116 0.020
Zebrafish
organic acid metabolic process GO:0006082 31 0.020
stem cell fate commitment GO:0048865 1 0.020
hypochord development GO:0055016 3 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.020
Human Mouse Fly
positive regulation of striated muscle cell differentiation GO:0051155 1 0.019
single organism biosynthetic process GO:0044711 71 0.019
ribonucleotide metabolic process GO:0009259 27 0.019
camera type eye photoreceptor cell differentiation GO:0060219 19 0.019
olfactory placode formation GO:0030910 1 0.019
Mouse
muscle cell fate determination GO:0007521 1 0.019
neuroblast fate determination GO:0007400 1 0.019
regulation of cell shape GO:0008360 1 0.019
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.019
auditory receptor cell fate specification GO:0042667 2 0.019
neural crest cell differentiation GO:0014033 72 0.019
regulation of skeletal muscle fiber development GO:0048742 2 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
positive regulation of nervous system development GO:0051962 25 0.019
mesodermal cell differentiation GO:0048333 21 0.019
developmental growth involved in morphogenesis GO:0060560 86 0.019
Mouse
enteric nervous system development GO:0048484 12 0.019
negative regulation of endothelial cell migration GO:0010596 1 0.019
response to external stimulus GO:0009605 264 0.019
Fly
regulation of axon extension involved in axon guidance GO:0048841 6 0.019
pigment cell differentiation GO:0050931 38 0.019
antimicrobial humoral response GO:0019730 2 0.019
positive regulation of cell motility GO:2000147 11 0.019
positive regulation of cell migration GO:0030335 11 0.019
blood vessel morphogenesis GO:0048514 216 0.018
Mouse
protein dephosphorylation GO:0006470 3 0.018
blood circulation GO:0008015 87 0.018
head morphogenesis GO:0060323 8 0.018
epithelial cell proliferation GO:0050673 17 0.018
Mouse
apoptotic process involved in development GO:1902742 2 0.018
myoblast fusion GO:0007520 10 0.018
kidney development GO:0001822 92 0.018
Zebrafish Mouse
regulation of signal transduction GO:0009966 225 0.018
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.018
female sex differentiation GO:0046660 4 0.018
positive regulation of programmed cell death GO:0043068 29 0.018
regulation of carbohydrate metabolic process GO:0006109 4 0.018
exocrine system development GO:0035272 28 0.017
epithelial cell morphogenesis GO:0003382 2 0.017
outflow tract morphogenesis GO:0003151 1 0.017
Mouse
positive regulation of epithelial cell proliferation GO:0050679 1 0.017
reactive nitrogen species metabolic process GO:2001057 0 0.017
sensory epithelium regeneration GO:0070654 14 0.017
Zebrafish
posterior lateral line neuromast deposition GO:0048922 5 0.017
negative regulation of collateral sprouting GO:0048671 2 0.017
embryonic camera type eye morphogenesis GO:0048596 19 0.017
Zebrafish
neuron projection morphogenesis GO:0048812 161 0.017
cell substrate adhesion GO:0031589 4 0.017
skeletal system development GO:0001501 181 0.017
Mouse
positive regulation of neural precursor cell proliferation GO:2000179 1 0.016
regulation of ectodermal cell fate specification GO:0042665 2 0.016
negative regulation of axon extension GO:0030517 7 0.016
positive regulation of response to stimulus GO:0048584 80 0.016
collateral sprouting in absence of injury GO:0048669 4 0.016
nucleoside phosphate metabolic process GO:0006753 28 0.016
regulation of phosphorus metabolic process GO:0051174 43 0.016
forebrain neuron fate commitment GO:0021877 1 0.016
single organism reproductive process GO:0044702 40 0.016
Fly
cell cycle GO:0007049 93 0.016
cellular ketone metabolic process GO:0042180 11 0.016
axon extension involved in axon guidance GO:0048846 10 0.016
negative regulation of neuron projection regeneration GO:0070571 4 0.016
aromatic compound catabolic process GO:0019439 15 0.016
secondary metabolic process GO:0019748 3 0.015
forebrain cell migration GO:0021885 1 0.015
ectodermal cell fate specification GO:0001715 2 0.015
neuron projection regeneration GO:0031102 16 0.015
renal tubule morphogenesis GO:0061333 1 0.015
Mouse
establishment of mitotic spindle localization GO:0040001 12 0.015
tube closure GO:0060606 1 0.015

six1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
auditory system disease DOID:2742 0 0.852
Human
autosomal dominant nonsyndromic deafness DOID:0050564 0 0.852
Human
nonsyndromic deafness DOID:0050563 0 0.852
Human
sensory system disease DOID:0050155 0 0.852
Human
disease of anatomical entity DOID:7 0 0.852
Human
nervous system disease DOID:863 0 0.852
Human
musculoskeletal system disease DOID:17 0 0.030
endocrine gland cancer DOID:170 0 0.027
thyroid cancer DOID:1781 0 0.027
cancer DOID:162 0 0.027
disease of cellular proliferation DOID:14566 0 0.027
organ system cancer DOID:0050686 0 0.027
eye and adnexa disease DOID:1492 0 0.016
eye disease DOID:5614 0 0.016
heart disease DOID:114 0 0.016
cardiovascular system disease DOID:1287 0 0.016