Danio rerio

14 known processes

six2a

sine oculis-related homeobox 2a

(Aliases: zgc:91945,MGC91945,wu:fj04e08,six2.1)

six2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sensory organ morphogenesis GO:0090596 200 0.916
Zebrafish Mouse Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.876
Zebrafish Mouse Fly
sensory organ development GO:0007423 393 0.866
Zebrafish Mouse Fly
embryonic organ morphogenesis GO:0048562 274 0.809
Zebrafish Mouse
central nervous system development GO:0007417 387 0.802
Zebrafish
stem cell proliferation GO:0072089 4 0.800
Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.741
Zebrafish Mouse Fly
embryonic organ development GO:0048568 381 0.720
Zebrafish Mouse
embryonic skeletal system morphogenesis GO:0048704 93 0.719
Mouse
brain development GO:0007420 293 0.673
Zebrafish
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.670
Zebrafish Mouse Fly
regionalization GO:0003002 274 0.653
Mouse
tube morphogenesis GO:0035239 349 0.648
Mouse
nucleic acid templated transcription GO:0097659 181 0.647
Zebrafish Mouse Fly
organic cyclic compound metabolic process GO:1901360 301 0.635
Zebrafish Mouse Fly
morphogenesis of an epithelium GO:0002009 333 0.629
Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.625
Zebrafish Mouse Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.619
Zebrafish Mouse Fly
regulation of cellular biosynthetic process GO:0031326 245 0.616
Zebrafish Mouse Fly
transcription dna templated GO:0006351 181 0.565
Zebrafish Mouse Fly
camera type eye morphogenesis GO:0048593 108 0.563
Zebrafish
rna metabolic process GO:0016070 219 0.561
Zebrafish Mouse Fly
regulation of macromolecule metabolic process GO:0060255 317 0.552
Zebrafish Mouse Fly
heart morphogenesis GO:0003007 156 0.533
camera type eye development GO:0043010 222 0.525
Zebrafish
anterior posterior pattern specification GO:0009952 152 0.506
Mouse
regulation of metabolic process GO:0019222 359 0.499
Zebrafish Mouse Fly
regulation of cellular metabolic process GO:0031323 320 0.498
Zebrafish Mouse Fly
regulation of multicellular organismal process GO:0051239 277 0.496
Zebrafish Mouse
eye development GO:0001654 277 0.473
Zebrafish Fly
cellular macromolecule metabolic process GO:0044260 391 0.471
Zebrafish Mouse Fly
head development GO:0060322 303 0.463
Zebrafish
specification of symmetry GO:0009799 204 0.455
signal transduction GO:0007165 455 0.452
inner ear receptor cell fate commitment GO:0060120 4 0.440
generation of neurons GO:0048699 385 0.437
Zebrafish
regulation of macromolecule biosynthetic process GO:0010556 225 0.434
Zebrafish Mouse Fly
axon development GO:0061564 166 0.426
nephron epithelium morphogenesis GO:0072088 1 0.390
Mouse
ear development GO:0043583 127 0.389
Zebrafish Mouse
nucleic acid metabolic process GO:0090304 244 0.385
Zebrafish Mouse Fly
embryonic skeletal system development GO:0048706 97 0.385
Mouse
regulation of rna biosynthetic process GO:2001141 213 0.381
Zebrafish Mouse Fly
aorta development GO:0035904 4 0.381
hematopoietic or lymphoid organ development GO:0048534 191 0.379
positive regulation of cellular process GO:0048522 201 0.373
Mouse Fly
embryonic camera type eye formation GO:0060900 10 0.372
embryonic heart tube morphogenesis GO:0003143 108 0.364
macromolecule biosynthetic process GO:0009059 227 0.364
Zebrafish Mouse Fly
cellular component morphogenesis GO:0032989 336 0.359
Mouse
embryonic heart tube development GO:0035050 133 0.353
proepicardium development GO:0003342 4 0.347
regulation of biosynthetic process GO:0009889 250 0.345
Zebrafish Mouse Fly
regulation of rna metabolic process GO:0051252 224 0.338
Zebrafish Mouse Fly
cellular aromatic compound metabolic process GO:0006725 295 0.332
Zebrafish Mouse Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.330
Zebrafish Mouse Fly
embryonic cranial skeleton morphogenesis GO:0048701 90 0.318
Mouse
immune system process GO:0002376 241 0.317
biosynthetic process GO:0009058 294 0.316
Zebrafish Mouse Fly
stem cell differentiation GO:0048863 117 0.312
Mouse
gene expression GO:0010467 252 0.311
Zebrafish Mouse Fly
regulation of primary metabolic process GO:0080090 311 0.311
Zebrafish Mouse Fly
rna biosynthetic process GO:0032774 181 0.306
Zebrafish Mouse Fly
embryonic camera type eye morphogenesis GO:0048596 19 0.292
Zebrafish
chordate embryonic development GO:0043009 271 0.286
Mouse
response to organic substance GO:0010033 153 0.284
vasculature development GO:0001944 278 0.284
hindbrain morphogenesis GO:0021575 22 0.283
neuron differentiation GO:0030182 353 0.281
Zebrafish
eye morphogenesis GO:0048592 144 0.277
Zebrafish Fly
nucleobase containing compound metabolic process GO:0006139 274 0.271
Zebrafish Mouse Fly
positive regulation of rna metabolic process GO:0051254 59 0.269
Mouse Fly
axon ensheathment GO:0008366 18 0.268
embryonic camera type eye development GO:0031076 29 0.268
Zebrafish
epithelial tube morphogenesis GO:0060562 148 0.261
Mouse
regulation of gene expression GO:0010468 265 0.259
Zebrafish Mouse Fly
outflow tract morphogenesis GO:0003151 1 0.254
epithelial cell differentiation GO:0030855 116 0.254
Mouse
pancreas development GO:0031016 84 0.252
embryonic eye morphogenesis GO:0048048 30 0.248
Zebrafish
regulation of stem cell proliferation GO:0072091 2 0.246
nitrogen compound metabolic process GO:0006807 319 0.244
Zebrafish Mouse Fly
mechanosensory lateral line system development GO:0048881 49 0.243
cellular nitrogen compound biosynthetic process GO:0044271 218 0.240
Zebrafish Mouse Fly
cellular component biogenesis GO:0044085 178 0.240
nucleobase containing compound biosynthetic process GO:0034654 205 0.240
Zebrafish Mouse Fly
auditory receptor cell fate commitment GO:0009912 4 0.239
mesenchymal cell development GO:0014031 78 0.235
organic substance biosynthetic process GO:1901576 289 0.231
Zebrafish Mouse Fly
forebrain generation of neurons GO:0021872 14 0.228
negative regulation of cellular biosynthetic process GO:0031327 55 0.221
cellular component movement GO:0006928 335 0.217
Human Fly
compound eye development GO:0048749 2 0.216
Fly
axonogenesis GO:0007409 152 0.214
peripheral nervous system neuron differentiation GO:0048934 28 0.213
Zebrafish
heart development GO:0007507 313 0.210
urogenital system development GO:0001655 97 0.210
primary neural tube formation GO:0014020 1 0.209
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.208
cellular nitrogen compound metabolic process GO:0034641 290 0.208
Zebrafish Mouse Fly
cell migration GO:0016477 237 0.208
Human Fly
positive regulation of gene expression GO:0010628 71 0.206
Mouse Fly
otic vesicle morphogenesis GO:0071600 34 0.205
positive regulation of stem cell proliferation GO:2000648 1 0.204
positive regulation of macromolecule metabolic process GO:0010604 93 0.202
Mouse Fly
auditory receptor cell fate determination GO:0042668 2 0.201
nephron tubule morphogenesis GO:0072078 1 0.200
Mouse
aging GO:0007568 2 0.198
regulation of axonogenesis GO:0050770 32 0.198
otic vesicle development GO:0071599 42 0.196
ectodermal placode development GO:0071696 37 0.195
Fly
artery morphogenesis GO:0048844 14 0.195
endocrine system development GO:0035270 65 0.195
Zebrafish Fly
inner ear development GO:0048839 126 0.194
Zebrafish
cell morphogenesis involved in differentiation GO:0000904 195 0.190
Mouse
immune system development GO:0002520 191 0.189
negative regulation of biosynthetic process GO:0009890 55 0.189
kidney development GO:0001822 92 0.189
cell fate commitment GO:0045165 99 0.188
Mouse
hindbrain development GO:0030902 91 0.188
neural tube development GO:0021915 62 0.187
endocrine pancreas development GO:0031018 27 0.185
renal tubule morphogenesis GO:0061333 1 0.184
Mouse
ectodermal placode morphogenesis GO:0071697 32 0.181
Fly
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.179
neural tube patterning GO:0021532 33 0.177
neuron fate determination GO:0048664 2 0.176
heart looping GO:0001947 94 0.168
retina development in camera type eye GO:0060041 146 0.168
lateral line system development GO:0048925 76 0.166
positive regulation of notch signaling pathway GO:0045747 3 0.165
pharyngeal system development GO:0060037 18 0.162
artery development GO:0060840 22 0.161
blood vessel morphogenesis GO:0048514 216 0.161
epithelial cell development GO:0002064 42 0.160
Mouse
lens development in camera type eye GO:0002088 22 0.159
embryonic viscerocranium morphogenesis GO:0048703 52 0.159
morphogenesis of embryonic epithelium GO:0016331 30 0.158
blood vessel development GO:0001568 246 0.155
otolith development GO:0048840 32 0.155
lateral line development GO:0048882 66 0.153
forebrain neuron differentiation GO:0021879 14 0.152
enzyme linked receptor protein signaling pathway GO:0007167 106 0.150
cell fate specification GO:0001708 68 0.150
Mouse
epidermal cell fate specification GO:0009957 4 0.150
positive regulation of biological process GO:0048518 253 0.143
Mouse Fly
muscle cell differentiation GO:0042692 139 0.143
Zebrafish
hepaticobiliary system development GO:0061008 98 0.143
heterocycle metabolic process GO:0046483 290 0.140
Zebrafish Mouse Fly
regulation of transcription dna templated GO:0006355 213 0.140
Zebrafish Mouse Fly
positive regulation of embryonic development GO:0040019 3 0.138
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.137
Zebrafish Mouse Fly
larval development GO:0002164 2 0.135
ear morphogenesis GO:0042471 64 0.134
Mouse
negative regulation of multicellular organismal process GO:0051241 69 0.133
inner ear morphogenesis GO:0042472 63 0.133
renal system development GO:0072001 94 0.133
otic vesicle formation GO:0030916 27 0.133
cranial ganglion development GO:0061550 3 0.132
positive regulation of nucleic acid templated transcription GO:1903508 57 0.131
Mouse Fly
dorsal ventral pattern formation GO:0009953 125 0.129
cell motility GO:0048870 244 0.128
Human Fly
embryo development ending in birth or egg hatching GO:0009792 271 0.128
Mouse
forebrain regionalization GO:0021871 4 0.125
negative regulation of biological process GO:0048519 304 0.125
Mouse
nephron morphogenesis GO:0072028 2 0.122
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.120
Mouse Fly
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.113
neuron fate commitment GO:0048663 26 0.112
hemopoiesis GO:0030097 183 0.112
regulation of biological quality GO:0065008 263 0.112
regulation of epithelial cell proliferation GO:0050678 3 0.111
regulation of organ morphogenesis GO:2000027 35 0.110
Mouse
optic placode formation involved in camera type eye formation GO:0046619 3 0.109
skeletal system development GO:0001501 181 0.108
Mouse
tube closure GO:0060606 1 0.108
retina morphogenesis in camera type eye GO:0060042 79 0.108
midbrain hindbrain boundary development GO:0030917 23 0.107
stem cell development GO:0048864 82 0.104
Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.104
multicellular organismal signaling GO:0035637 22 0.103
determination of left right symmetry GO:0007368 179 0.103
cardiogenic plate morphogenesis GO:0003142 1 0.102
photoreceptor cell fate specification GO:0043704 1 0.100
pericardium development GO:0060039 1 0.100
regulation of neurogenesis GO:0050767 87 0.099
Zebrafish
somite development GO:0061053 96 0.098
digestive system development GO:0055123 289 0.097
Zebrafish Mouse
cell surface receptor signaling pathway GO:0007166 325 0.097
posterior lateral line nerve development GO:0048918 8 0.097
sympathetic nervous system development GO:0048485 3 0.096
neural crest cell differentiation GO:0014033 72 0.096
epithelial cell fate commitment GO:0072148 11 0.095
system process GO:0003008 185 0.095
sensory system development GO:0048880 76 0.094
negative regulation of cellular metabolic process GO:0031324 77 0.093
cilium morphogenesis GO:0060271 85 0.092
ectodermal placode formation GO:0060788 26 0.092
Fly
skeletal system morphogenesis GO:0048705 102 0.092
Mouse
heterocycle biosynthetic process GO:0018130 215 0.092
Zebrafish Mouse Fly
lateral line nerve development GO:0048892 9 0.092
tube formation GO:0035148 25 0.091
digestive tract development GO:0048565 265 0.090
Zebrafish Mouse
mesodermal cell fate commitment GO:0001710 14 0.090
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.090
Mouse Fly
cellular biosynthetic process GO:0044249 286 0.089
Zebrafish Mouse Fly
neuroblast proliferation GO:0007405 2 0.089
determination of heart left right asymmetry GO:0061371 117 0.088
olfactory bulb development GO:0021772 4 0.088
regulation of sodium ion transport GO:0002028 2 0.088
liver development GO:0001889 96 0.088
positive regulation of biosynthetic process GO:0009891 68 0.087
Mouse Fly
cell morphogenesis GO:0000902 289 0.087
Mouse
aromatic compound biosynthetic process GO:0019438 217 0.086
Zebrafish Mouse Fly
somitogenesis GO:0001756 87 0.085
growth GO:0040007 174 0.085
Zebrafish
radial glial cell differentiation GO:0060019 2 0.084
aorta morphogenesis GO:0035909 3 0.084
pectoral fin development GO:0033339 50 0.084
response to chemical GO:0042221 320 0.083
hematopoietic stem cell differentiation GO:0060218 20 0.083
embryonic epithelial tube formation GO:0001838 17 0.083
skin development GO:0043588 54 0.083
septum transversum development GO:0003343 4 0.082
nephron development GO:0072006 31 0.082
Mouse
otic placode formation GO:0043049 23 0.082
regulation of cardiac muscle cell contraction GO:0086004 1 0.082
gland development GO:0048732 143 0.082
Zebrafish Fly
hematopoietic progenitor cell differentiation GO:0002244 23 0.081
type b pancreatic cell development GO:0003323 4 0.081
semicircular canal development GO:0060872 24 0.081
cellular response to external stimulus GO:0071496 2 0.081
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.081
epidermal cell differentiation GO:0009913 36 0.079
locomotion GO:0040011 313 0.079
Human Fly
negative regulation of transcription dna templated GO:0045892 45 0.078
autonomic nervous system development GO:0048483 19 0.077
polarized epithelial cell differentiation GO:0030859 4 0.077
photoreceptor cell development GO:0042461 40 0.076
regulation of cell communication GO:0010646 232 0.075
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.075
Mouse Fly
regulation of cell development GO:0060284 100 0.074
Zebrafish
regulation of signal transduction GO:0009966 225 0.074
peripheral nervous system neuron development GO:0048935 22 0.074
Zebrafish
rhombomere 5 development GO:0021571 4 0.073
connective tissue development GO:0061448 99 0.073
Mouse
specification of organ identity GO:0010092 2 0.072
mesenchymal cell differentiation GO:0048762 87 0.072
Mouse
positive regulation of rna biosynthetic process GO:1902680 57 0.072
Mouse Fly
myeloid cell differentiation GO:0030099 86 0.072
positive regulation of metabolic process GO:0009893 108 0.072
Mouse Fly
response to monosaccharide GO:0034284 3 0.070
somatic stem cell maintenance GO:0035019 1 0.069
Mouse
regulation of muscle contraction GO:0006937 3 0.069
vasculogenesis GO:0001570 41 0.069
epithelial tube formation GO:0072175 19 0.069
cell projection assembly GO:0030031 64 0.069
lipid storage GO:0019915 1 0.068
positive regulation of transport GO:0051050 2 0.068
myelination GO:0042552 18 0.067
gastrulation GO:0007369 208 0.067
Mouse
endocardium formation GO:0060214 1 0.067
regulation of signaling GO:0023051 235 0.067
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.066
Mouse Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.066
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.066
developmental growth GO:0048589 166 0.065
Zebrafish
semicircular canal morphogenesis GO:0048752 18 0.065
negative regulation of nucleic acid templated transcription GO:1903507 45 0.065
transcription from rna polymerase ii promoter GO:0006366 80 0.064
Zebrafish Mouse Fly
optomotor response GO:0071632 1 0.064
forebrain neuron development GO:0021884 7 0.064
cardiocyte differentiation GO:0035051 44 0.063
single organism transport GO:0044765 206 0.063
Mouse
regulation of mesenchymal cell proliferation GO:0010464 1 0.063
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.062
negative regulation of rna metabolic process GO:0051253 48 0.062
inner ear receptor cell differentiation GO:0060113 29 0.061
Zebrafish
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.061
posterior lateral line neuromast hair cell differentiation GO:0048923 8 0.060
ensheathment of neurons GO:0007272 18 0.060
erythrocyte homeostasis GO:0034101 55 0.060
positive regulation of cellular biosynthetic process GO:0031328 68 0.059
Mouse Fly
epithelium regeneration GO:1990399 14 0.059
Zebrafish
extracellular structure organization GO:0043062 27 0.059
embryonic pattern specification GO:0009880 44 0.058
gabaergic neuron differentiation GO:0097154 2 0.058
ameboidal type cell migration GO:0001667 143 0.058
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.057
lens morphogenesis in camera type eye GO:0002089 7 0.057
erythrocyte differentiation GO:0030218 54 0.057
endoderm development GO:0007492 49 0.057
regulation of membrane potential GO:0042391 23 0.057
phagocytosis GO:0006909 3 0.055
epithelial cell morphogenesis GO:0003382 2 0.055
Mouse
regulation of organ growth GO:0046620 3 0.055
establishment of localization GO:0051234 244 0.054
Mouse
optic placode formation GO:0001743 4 0.054
Fly
epithelium migration GO:0090132 25 0.054
regulation of hormone metabolic process GO:0032350 6 0.054
cell proliferation GO:0008283 80 0.054
Human Zebrafish Mouse
central nervous system neuron differentiation GO:0021953 74 0.054
muscle structure development GO:0061061 196 0.054
Zebrafish
diencephalon development GO:0021536 58 0.053
Zebrafish
appendage morphogenesis GO:0035107 56 0.053
protein metabolic process GO:0019538 183 0.053
forebrain development GO:0030900 96 0.052
Zebrafish
cellular component assembly GO:0022607 170 0.052
cell projection morphogenesis GO:0048858 244 0.052
nephron epithelium development GO:0072009 16 0.052
Mouse
wound healing GO:0042060 90 0.052
Zebrafish
pronephros development GO:0048793 69 0.052
single fertilization GO:0007338 3 0.051
regulation of mrna splicing via spliceosome GO:0048024 3 0.051
localization of cell GO:0051674 244 0.051
Human Fly
heart jogging GO:0003146 40 0.051
response to external stimulus GO:0009605 264 0.051
Fly
pectoral fin morphogenesis GO:0035138 29 0.050
determination of bilateral symmetry GO:0009855 204 0.050
regulation of skeletal muscle tissue development GO:0048641 4 0.050
mesodermal cell differentiation GO:0048333 21 0.049
Mouse
embryonic hemopoiesis GO:0035162 53 0.049
mesenchyme development GO:0060485 127 0.049
Mouse
regulation of mechanoreceptor differentiation GO:0045631 1 0.049
Zebrafish
regulation of embryonic development GO:0045995 47 0.048
olfactory lobe development GO:0021988 4 0.048
rostrocaudal neural tube patterning GO:0021903 29 0.048
regulation of reproductive process GO:2000241 4 0.048
response to stress GO:0006950 263 0.048
Zebrafish
positive regulation of cellular catabolic process GO:0031331 3 0.047
homeostasis of number of cells GO:0048872 62 0.047
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.047
actin filament based process GO:0030029 64 0.047
pronephric nephron development GO:0039019 14 0.046
striated muscle tissue development GO:0014706 110 0.046
Zebrafish
neuron projection extension GO:1990138 45 0.046
developmental growth involved in morphogenesis GO:0060560 86 0.046
organ formation GO:0048645 17 0.046
regulation of endothelial cell differentiation GO:0045601 3 0.046
sympathetic ganglion development GO:0061549 2 0.045
exocrine system development GO:0035272 28 0.045
regulation of inner ear receptor cell differentiation GO:2000980 1 0.045
Zebrafish
mesoderm morphogenesis GO:0048332 51 0.044
Mouse
mesenchymal cell proliferation GO:0010463 1 0.044
cellular localization GO:0051641 97 0.044
Mouse
forebrain cell migration GO:0021885 1 0.043
regulation of stem cell differentiation GO:2000736 4 0.043
adenohypophysis development GO:0021984 15 0.043
Zebrafish
vestibular receptor cell development GO:0060118 3 0.043
cell projection organization GO:0030030 284 0.043
regulation of heart contraction GO:0008016 32 0.043
notochord development GO:0030903 54 0.043
retinal rod cell development GO:0046548 4 0.043
stem cell maintenance GO:0019827 4 0.042
Mouse
hair cell differentiation GO:0035315 32 0.041
single organism organelle organization GO:1902589 199 0.041
nose development GO:0043584 3 0.041
ventricular system development GO:0021591 12 0.041
nerve development GO:0021675 45 0.041
tissue regeneration GO:0042246 74 0.041
Zebrafish
neurological system process GO:0050877 62 0.041
negative regulation of heart contraction GO:0045822 2 0.041
cellular component assembly involved in morphogenesis GO:0010927 107 0.041
cellular response to organic substance GO:0071310 105 0.040
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.040
transmission of nerve impulse GO:0019226 19 0.040
positive regulation of multicellular organismal process GO:0051240 52 0.040
regulation of cell differentiation GO:0045595 142 0.040
Zebrafish Mouse
rhombomere development GO:0021546 19 0.040
exocrine pancreas development GO:0031017 28 0.039
axon guidance GO:0007411 86 0.039
gland morphogenesis GO:0022612 13 0.039
response to carbohydrate GO:0009743 3 0.039
negative regulation of rna biosynthetic process GO:1902679 45 0.039
muscle organ development GO:0007517 101 0.039
Zebrafish
otolith morphogenesis GO:0032474 8 0.038
regulation of multicellular organismal development GO:2000026 223 0.038
Zebrafish Mouse
pronephric glomerulus development GO:0039021 13 0.038
endocardial cushion development GO:0003197 6 0.038
posterior lateral line development GO:0048916 38 0.038
synaptic growth at neuromuscular junction GO:0051124 2 0.038
ossification GO:0001503 23 0.038
Mouse
mesoderm formation GO:0001707 43 0.038
Mouse
neuronal action potential GO:0019228 18 0.038
organelle organization GO:0006996 227 0.037
negative regulation of cell differentiation GO:0045596 46 0.037
Mouse
bmp signaling pathway GO:0030509 52 0.037
pons development GO:0021548 11 0.037
regulation of cellular amino acid metabolic process GO:0006521 0 0.036
regeneration GO:0031099 91 0.036
Zebrafish
appendage development GO:0048736 80 0.036
negative regulation of blood circulation GO:1903523 2 0.036
positive regulation of epithelial cell differentiation GO:0030858 2 0.036
regulation of cellular component organization GO:0051128 86 0.036
cranial nerve development GO:0021545 42 0.036
regulation of cellular response to growth factor stimulus GO:0090287 35 0.036
posterior lateral line neuromast development GO:0048919 20 0.035
primitive hemopoiesis GO:0060215 27 0.035
odontogenesis of dentin containing tooth GO:0042475 1 0.035
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.035
Mouse
neuromast development GO:0048884 46 0.035
adult behavior GO:0030534 2 0.035
neuromast hair cell differentiation GO:0048886 12 0.035
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.034
negative regulation of macromolecule metabolic process GO:0010605 76 0.034
regulation of tube size GO:0035150 2 0.034
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.034
epidermis development GO:0008544 48 0.034
positive regulation of cell cycle GO:0045787 3 0.034
positive regulation of endothelial cell differentiation GO:0045603 2 0.034
neuroblast differentiation GO:0014016 1 0.034
olfactory placode development GO:0071698 12 0.033
axis elongation GO:0003401 31 0.033
embryonic heart tube formation GO:0003144 1 0.033
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.033
heart contraction GO:0060047 71 0.033
leukocyte differentiation GO:0002521 25 0.033
axon regeneration GO:0031103 14 0.033
locus ceruleus development GO:0021703 3 0.033
limb bud formation GO:0060174 2 0.032
startle response GO:0001964 4 0.032
mechanoreceptor differentiation GO:0042490 37 0.032
Zebrafish
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.032
angiogenesis GO:0001525 158 0.032
neuron projection morphogenesis GO:0048812 161 0.032
convergent extension GO:0060026 118 0.032
development of primary female sexual characteristics GO:0046545 4 0.032
positive regulation of transcription dna templated GO:0045893 57 0.032
Mouse Fly
regulation of cell shape GO:0008360 1 0.032
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.032
segmentation GO:0035282 97 0.031
cytoskeleton organization GO:0007010 96 0.031
skeletal muscle tissue development GO:0007519 67 0.031
Zebrafish
positive regulation of reproductive process GO:2000243 2 0.031
enteric nervous system development GO:0048484 12 0.031
lens fiber cell development GO:0070307 3 0.031
regulation of nervous system development GO:0051960 90 0.031
Zebrafish
anterior lateral line system development GO:0048898 9 0.031
posterior lateral line system development GO:0048915 46 0.031
extrinsic apoptotic signaling pathway GO:0097191 3 0.031
anterior lateral line nerve development GO:0048909 4 0.030
endothelial cell differentiation GO:0045446 20 0.030
rhombomere morphogenesis GO:0021593 17 0.030
regulation of bmp signaling pathway GO:0030510 39 0.030
tissue migration GO:0090130 37 0.030
regulation of developmental process GO:0050793 247 0.030
Zebrafish Mouse
response to other organism GO:0051707 97 0.029
lens fiber cell morphogenesis GO:0070309 3 0.029
neural plate regionalization GO:0060897 10 0.029
sex determination GO:0007530 1 0.029
response to wounding GO:0009611 116 0.029
Zebrafish
sensory epithelium regeneration GO:0070654 14 0.029
Zebrafish
chemotaxis GO:0006935 104 0.029
taxis GO:0042330 109 0.029
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.029
multi organism process GO:0051704 134 0.029
Fly
positive regulation of epithelial cell proliferation GO:0050679 1 0.029
embryonic appendage morphogenesis GO:0035113 30 0.029
response to glucose GO:0009749 3 0.028
trigeminal nerve development GO:0021559 3 0.028
regulation of meiotic cell cycle GO:0051445 1 0.028
neural retina development GO:0003407 49 0.028
regulation of skeletal muscle cell differentiation GO:2001014 1 0.028
cellular response to stress GO:0033554 62 0.028
female sex differentiation GO:0046660 4 0.028
cardiac atrium development GO:0003230 4 0.028
negative regulation of cellular process GO:0048523 283 0.028
Mouse
determination of dorsal ventral asymmetry GO:0048262 34 0.028
myeloid cell homeostasis GO:0002262 56 0.028
epithelial cell migration GO:0010631 25 0.028
regulation of mrna processing GO:0050684 3 0.027
non canonical wnt signaling pathway GO:0035567 13 0.027
cell proliferation in forebrain GO:0021846 3 0.027
cellular response to extracellular stimulus GO:0031668 2 0.027
cell death GO:0008219 121 0.027
cell proliferation involved in heart morphogenesis GO:0061323 2 0.027
blood circulation GO:0008015 87 0.027
response to hexose GO:0009746 3 0.027
apoptotic process involved in development GO:1902742 2 0.026
neural crest cell migration GO:0001755 42 0.026
fin development GO:0033333 77 0.026
mesodermal cell fate specification GO:0007501 12 0.026
Mouse
peptide metabolic process GO:0006518 1 0.026
negative regulation of stem cell differentiation GO:2000737 2 0.026
positive regulation of signal transduction GO:0009967 56 0.026
programmed cell death GO:0012501 119 0.026
respiratory system development GO:0060541 5 0.026

six2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
auditory system disease DOID:2742 0 0.045
autosomal dominant nonsyndromic deafness DOID:0050564 0 0.045
nonsyndromic deafness DOID:0050563 0 0.045
sensory system disease DOID:0050155 0 0.045
disease of anatomical entity DOID:7 0 0.045
nervous system disease DOID:863 0 0.045
disease of cellular proliferation DOID:14566 0 0.041
cancer DOID:162 0 0.029