Danio rerio

0 known processes

skp1

S-phase kinase-associated protein 1

(Aliases: MGC73186,skp1a,zgc:73186)

skp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
signal transduction GO:0007165 455 0.324
larval development GO:0002164 2 0.267
Worm
maintenance of location GO:0051235 4 0.158
gene expression GO:0010467 252 0.152
Worm
cellular nitrogen compound metabolic process GO:0034641 290 0.140
cell migration GO:0016477 237 0.134
Worm
nuclear migration GO:0007097 3 0.131
regulation of meiotic cell cycle GO:0051445 1 0.128
Worm
pronuclear migration GO:0035046 1 0.126
aging GO:0007568 2 0.116
Worm
nucleoside monophosphate catabolic process GO:0009125 4 0.113
regulation of macromolecule metabolic process GO:0060255 317 0.109
Worm
response to chemical GO:0042221 320 0.097
single fertilization GO:0007338 3 0.091
atp catabolic process GO:0006200 4 0.091
regulation of multicellular organismal process GO:0051239 277 0.085
regulation of response to stimulus GO:0048583 269 0.083
heterocycle metabolic process GO:0046483 290 0.079
regulation of gene expression GO:0010468 265 0.079
Worm
lipid storage GO:0019915 1 0.078
meiotic cell cycle process GO:1903046 3 0.076
Worm
multi organism process GO:0051704 134 0.073
Worm
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.072
regulation of signaling GO:0023051 235 0.072
cell surface receptor signaling pathway GO:0007166 325 0.072
ribonucleoside monophosphate catabolic process GO:0009158 4 0.070
organic cyclic compound metabolic process GO:1901360 301 0.068
regulation of biological quality GO:0065008 263 0.067
regulation of primary metabolic process GO:0080090 311 0.067
cellular aromatic compound metabolic process GO:0006725 295 0.066
purine nucleoside monophosphate catabolic process GO:0009128 4 0.063
response to organic substance GO:0010033 153 0.063
cellular response to chemical stimulus GO:0070887 157 0.063
mitotic cell cycle GO:0000278 64 0.059
Worm
intracellular signal transduction GO:0035556 85 0.059
negative regulation of biological process GO:0048519 304 0.059
Worm
nucleobase containing small molecule metabolic process GO:0055086 32 0.059
organonitrogen compound metabolic process GO:1901564 74 0.058
regulation of establishment of protein localization GO:0070201 4 0.057
small molecule metabolic process GO:0044281 77 0.057
death GO:0016265 121 0.054
Worm
establishment of localization GO:0051234 244 0.053
Worm
neuron development GO:0048666 262 0.052
regulation of metabolic process GO:0019222 359 0.052
Worm
single organism organelle organization GO:1902589 199 0.051
Human Worm
nuclear transport GO:0051169 4 0.051
cellular protein catabolic process GO:0044257 4 0.050
Human
response to drug GO:0042493 3 0.050
ubiquitin dependent protein catabolic process GO:0006511 3 0.049
Human
stem cell proliferation GO:0072089 4 0.048
localization of cell GO:0051674 244 0.047
Worm
protein metabolic process GO:0019538 183 0.046
Human
cellular component movement GO:0006928 335 0.045
Worm
fertilization GO:0009566 3 0.044
regulation of cell differentiation GO:0045595 142 0.043
sensory organ development GO:0007423 393 0.042
regulation of cellular amine metabolic process GO:0033238 0 0.042
nucleocytoplasmic transport GO:0006913 4 0.042
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.041
cellular macromolecule metabolic process GO:0044260 391 0.041
Human
pole plasm assembly GO:0007315 4 0.040
negative regulation of protein phosphorylation GO:0001933 4 0.040
embryo development ending in birth or egg hatching GO:0009792 271 0.040
Worm
cellular response to organic substance GO:0071310 105 0.039
positive regulation of transport GO:0051050 2 0.039
amine metabolic process GO:0009308 2 0.039
negative regulation of cellular process GO:0048523 283 0.038
Worm
transport GO:0006810 220 0.038
Worm
cell motility GO:0048870 244 0.038
Worm
response to stress GO:0006950 263 0.038
Worm
response to uv GO:0009411 3 0.037
cellular component assembly GO:0022607 170 0.037
protein localization to nucleus GO:0034504 3 0.037
cellular component biogenesis GO:0044085 178 0.037
regulation of gene expression epigenetic GO:0040029 11 0.036
Worm
rna metabolic process GO:0016070 219 0.036
cellular localization GO:0051641 97 0.036
Worm
negative regulation of macromolecule metabolic process GO:0010605 76 0.036
Worm
multicellular organism growth GO:0035264 4 0.035
eye development GO:0001654 277 0.035
phosphorus metabolic process GO:0006793 109 0.035
nucleobase containing compound metabolic process GO:0006139 274 0.035
regulation of nucleocytoplasmic transport GO:0046822 2 0.034
macromolecule localization GO:0033036 54 0.034
meiotic nuclear division GO:0007126 4 0.034
Worm
response to external stimulus GO:0009605 264 0.033
Worm
positive regulation of biological process GO:0048518 253 0.033
Worm
modification dependent protein catabolic process GO:0019941 3 0.033
Human
meiotic chromosome segregation GO:0045132 3 0.033
Worm
nitrogen compound metabolic process GO:0006807 319 0.032
apoptotic process involved in development GO:1902742 2 0.032
spindle assembly GO:0051225 2 0.032
locomotion GO:0040011 313 0.032
Worm
positive regulation of cell cycle GO:0045787 3 0.031
regulation of cellular amino acid metabolic process GO:0006521 0 0.031
homeostatic process GO:0042592 142 0.031
negative regulation of chromosome organization GO:2001251 1 0.031
immune system process GO:0002376 241 0.031
Worm
cellular amine metabolic process GO:0044106 2 0.030
negative regulation of protein transport GO:0051224 3 0.030
neuron differentiation GO:0030182 353 0.030
compound eye development GO:0048749 2 0.030
regulation of protein localization to nucleus GO:1900180 2 0.030
single organism localization GO:1902578 225 0.030
Worm
regulation of localization GO:0032879 104 0.029
positive regulation of cellular catabolic process GO:0031331 3 0.029
regulation of developmental process GO:0050793 247 0.029
single organism transport GO:0044765 206 0.029
single organism metabolic process GO:0044710 217 0.029
Human
anterior posterior pattern specification GO:0009952 152 0.029
immune system development GO:0002520 191 0.028
regulation of cytokine production GO:0001817 3 0.028
negative regulation of gene expression GO:0010629 65 0.028
Worm
regulation of cytoplasmic transport GO:1903649 4 0.027
meiosis ii GO:0007135 1 0.027
regulation of cell shape GO:0008360 1 0.027
cell proliferation GO:0008283 80 0.027
Worm
single organism nuclear import GO:1902593 3 0.027
system process GO:0003008 185 0.027
protein polymerization GO:0051258 4 0.027
regulation of protein depolymerization GO:1901879 1 0.026
cellular ketone metabolic process GO:0042180 11 0.026
phosphate containing compound metabolic process GO:0006796 108 0.026
positive regulation of apoptotic signaling pathway GO:2001235 1 0.026
inner ear development GO:0048839 126 0.026
regulation of cellular ketone metabolic process GO:0010565 7 0.026
chromosome organization GO:0051276 31 0.026
Human
development of primary female sexual characteristics GO:0046545 4 0.025
epithelial cell differentiation GO:0030855 116 0.024
regulation of cellular metabolic process GO:0031323 320 0.024
proteasomal protein catabolic process GO:0010498 2 0.024
Human
regulation of binding GO:0051098 3 0.024
enzyme linked receptor protein signaling pathway GO:0007167 106 0.024
positive regulation of metabolic process GO:0009893 108 0.024
protein import into nucleus GO:0006606 3 0.024
microtubule polymerization or depolymerization GO:0031109 3 0.024
sleep GO:0030431 1 0.024
regulation of nitrogen compound metabolic process GO:0051171 251 0.024
regulation of protein metabolic process GO:0051246 56 0.023
microtubule based process GO:0007017 60 0.023
Worm
mitotic dna integrity checkpoint GO:0044774 4 0.023
developmental programmed cell death GO:0010623 4 0.023
regulation of intracellular protein transport GO:0033157 3 0.023
regulation of protein transport GO:0051223 3 0.023
regulation of stem cell differentiation GO:2000736 4 0.023
organelle organization GO:0006996 227 0.023
Human Worm
cellular component disassembly GO:0022411 1 0.022
chordate embryonic development GO:0043009 271 0.022
membrane fusion GO:0061025 2 0.022
regulation of protein targeting GO:1903533 2 0.022
generation of neurons GO:0048699 385 0.022
alternative mrna splicing via spliceosome GO:0000380 1 0.021
regulation of nucleic acid templated transcription GO:1903506 213 0.021
negative regulation of protein localization to nucleus GO:1900181 2 0.021
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.021
regulation of oocyte development GO:0060281 3 0.021
cellular protein modification process GO:0006464 100 0.021
Human
neuroblast proliferation GO:0007405 2 0.021
meiosis i GO:0007127 1 0.021
regionalization GO:0003002 274 0.021
regulation of catalytic activity GO:0050790 55 0.021
regulation of protein import into nucleus GO:0042306 2 0.021
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.021
regulation of mrna processing GO:0050684 3 0.021
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.020
Human
regulation of reproductive process GO:2000241 4 0.020
nuclear import GO:0051170 3 0.020
rna transport GO:0050658 2 0.020
ribonucleotide metabolic process GO:0009259 27 0.020
regulation of cell cycle GO:0051726 52 0.020
Worm
positive regulation of cellular process GO:0048522 201 0.020
Worm
nucleic acid metabolic process GO:0090304 244 0.020
nucleoside phosphate metabolic process GO:0006753 28 0.020
catabolic process GO:0009056 32 0.020
Human
negative regulation of protein kinase activity GO:0006469 4 0.020
oocyte anterior posterior axis specification GO:0007314 4 0.020
biosynthetic process GO:0009058 294 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
Human
positive regulation of catabolic process GO:0009896 4 0.019
spindle assembly involved in mitosis GO:0090307 1 0.019
gland development GO:0048732 143 0.019
female sex differentiation GO:0046660 4 0.019
camera type eye development GO:0043010 222 0.019
segmentation GO:0035282 97 0.019
cell morphogenesis GO:0000902 289 0.019
organic substance catabolic process GO:1901575 28 0.019
Human
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.019
regulation of cell activation GO:0050865 1 0.019
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.019
cell projection organization GO:0030030 284 0.019
hematopoietic or lymphoid organ development GO:0048534 191 0.019
regulation of cell communication GO:0010646 232 0.018
negative regulation of intracellular transport GO:0032387 3 0.018
regulation of chromosome segregation GO:0051983 1 0.018
negative regulation of cytoplasmic transport GO:1903650 2 0.018
muscle structure development GO:0061061 196 0.018
cell part morphogenesis GO:0032990 246 0.018
response to endogenous stimulus GO:0009719 83 0.018
dna templated transcription initiation GO:0006352 1 0.018
rna localization GO:0006403 4 0.018
chromosome organization involved in meiosis GO:0070192 1 0.018
regulation of molecular function GO:0065009 70 0.018
ear development GO:0043583 127 0.018
nuclear export GO:0051168 1 0.018
protein acetylation GO:0006473 2 0.018
response to abiotic stimulus GO:0009628 122 0.018
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.017
stem cell division GO:0017145 1 0.017
adult behavior GO:0030534 2 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
membrane invagination GO:0010324 1 0.017
hemopoiesis GO:0030097 183 0.017
regulation of protein ubiquitination GO:0031396 3 0.017
ribose phosphate metabolic process GO:0019693 27 0.017
centrosome organization GO:0051297 1 0.017
regulation of signal transduction GO:0009966 225 0.017
regulation of intracellular signal transduction GO:1902531 57 0.016
negative regulation of map kinase activity GO:0043407 2 0.016
negative regulation of kinase activity GO:0033673 4 0.016
regulation of multicellular organism growth GO:0040014 4 0.016
heart development GO:0007507 313 0.016
i kappab kinase nf kappab signaling GO:0007249 4 0.016
protein complex disassembly GO:0043241 1 0.016
cell cycle g2 m phase transition GO:0044839 4 0.016
vasculature development GO:0001944 278 0.016
extrinsic apoptotic signaling pathway GO:0097191 3 0.016
protein targeting to nucleus GO:0044744 3 0.016
spermatid development GO:0007286 2 0.016
regulation of cellular component organization GO:0051128 86 0.016
heart contraction GO:0060047 71 0.016
positive regulation of cell communication GO:0010647 56 0.016
macromolecular complex subunit organization GO:0043933 74 0.016
Human
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.016
regulation of cellular protein metabolic process GO:0032268 52 0.016
gtp metabolic process GO:0046039 4 0.016
nucleotide metabolic process GO:0009117 28 0.016
purine containing compound metabolic process GO:0072521 29 0.015
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.015
guanosine containing compound catabolic process GO:1901069 2 0.015
protein depolymerization GO:0051261 1 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
female gonad development GO:0008585 4 0.015
digestive system development GO:0055123 289 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
positive regulation of cell activation GO:0050867 1 0.015
regulation of epithelial cell proliferation GO:0050678 3 0.015
cellular biosynthetic process GO:0044249 286 0.015
nuclear division GO:0000280 23 0.015
Worm
regulation of sequestering of calcium ion GO:0051282 4 0.015
protein dephosphorylation GO:0006470 3 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.015
growth GO:0040007 174 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.014
response to biotic stimulus GO:0009607 97 0.014
Worm
cellular protein metabolic process GO:0044267 129 0.014
Human
signal transduction in absence of ligand GO:0038034 1 0.014
apoptotic process involved in morphogenesis GO:0060561 2 0.014
cellular response to light stimulus GO:0071482 4 0.014
multi organism reproductive process GO:0044703 36 0.014
Worm
nucleobase containing compound biosynthetic process GO:0034654 205 0.014
cytoskeleton organization GO:0007010 96 0.014
Worm
mitotic sister chromatid segregation GO:0000070 6 0.014
cellular amino acid metabolic process GO:0006520 7 0.014
nucleobase containing compound transport GO:0015931 2 0.014
regulation of protein binding GO:0043393 3 0.014
modification dependent macromolecule catabolic process GO:0043632 3 0.014
Human
maternal determination of anterior posterior axis embryo GO:0008358 4 0.014
mitotic cell cycle embryonic GO:0045448 2 0.014
mechanosensory behavior GO:0007638 2 0.014
nucleic acid transport GO:0050657 2 0.014
cellular response to endogenous stimulus GO:0071495 68 0.014
golgi vesicle transport GO:0048193 3 0.014
protein polyubiquitination GO:0000209 4 0.014
peptidyl serine phosphorylation GO:0018105 1 0.014
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.014
regulation of protein phosphorylation GO:0001932 18 0.014
semicircular canal development GO:0060872 24 0.014
muscle organ development GO:0007517 101 0.014
somitogenesis GO:0001756 87 0.014
negative regulation of cytokine production GO:0001818 1 0.014
protein import GO:0017038 3 0.013
regulation of phosphate metabolic process GO:0019220 43 0.013
regulation of rna biosynthetic process GO:2001141 213 0.013
centrosome cycle GO:0007098 1 0.013
carbohydrate derivative metabolic process GO:1901135 61 0.013
organic substance transport GO:0071702 58 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.013
cognition GO:0050890 1 0.013
organic acid metabolic process GO:0006082 31 0.013
organic substance biosynthetic process GO:1901576 289 0.013
cytoplasm organization GO:0007028 4 0.013
gtp catabolic process GO:0006184 2 0.013
peptide transport GO:0015833 1 0.013
negative regulation of cellular component organization GO:0051129 16 0.013
maturation of ssu rrna GO:0030490 1 0.013
head development GO:0060322 303 0.013
atp synthesis coupled electron transport GO:0042773 1 0.013
single organism intracellular transport GO:1902582 25 0.013
neuron projection development GO:0031175 180 0.013
small gtpase mediated signal transduction GO:0007264 8 0.013
negative regulation of catabolic process GO:0009895 3 0.013
regulation of kinase activity GO:0043549 15 0.013
stem cell maintenance GO:0019827 4 0.013
lateral inhibition GO:0046331 1 0.013
negative regulation of histone modification GO:0031057 1 0.013
mitochondrial atp synthesis coupled electron transport GO:0042775 1 0.012
cellular response to external stimulus GO:0071496 2 0.012
macromolecular complex disassembly GO:0032984 1 0.012
morphogenesis of an epithelium GO:0002009 333 0.012
erk1 and erk2 cascade GO:0070371 4 0.012
oxoacid metabolic process GO:0043436 31 0.012
negative regulation of protein metabolic process GO:0051248 16 0.012
positive regulation of signaling GO:0023056 56 0.012
response to external biotic stimulus GO:0043207 97 0.012
Worm
cellular component morphogenesis GO:0032989 336 0.012
reproduction GO:0000003 40 0.012
Worm
carboxylic acid metabolic process GO:0019752 22 0.012
regulation of blood pressure GO:0008217 1 0.012
ribosomal small subunit biogenesis GO:0042274 2 0.012
positive regulation of immune effector process GO:0002699 3 0.012
phosphorylation GO:0016310 69 0.012
mrna transport GO:0051028 2 0.012
protein complex localization GO:0031503 1 0.012
negative regulation of gliogenesis GO:0014014 1 0.012
establishment of rna localization GO:0051236 3 0.012
protein stabilization GO:0050821 2 0.012
autophagy GO:0006914 4 0.012
central nervous system development GO:0007417 387 0.012
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.012
regulation of biosynthetic process GO:0009889 250 0.012
negative regulation of defense response GO:0031348 2 0.012
regulation of cell development GO:0060284 100 0.012
apoptotic process GO:0006915 116 0.012
Worm
programmed cell death GO:0012501 119 0.012
Worm
organelle assembly GO:0070925 110 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
rna processing GO:0006396 25 0.012
regulation of metal ion transport GO:0010959 4 0.012
neuron fate determination GO:0048664 2 0.012
organophosphate metabolic process GO:0019637 37 0.012
phagocytosis GO:0006909 3 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
macromolecule modification GO:0043412 111 0.011
Human
response to oxygen containing compound GO:1901700 55 0.011
pharyngeal muscle development GO:0043282 4 0.011
cell projection morphogenesis GO:0048858 244 0.011
intracellular transport GO:0046907 32 0.011
organelle fusion GO:0048284 3 0.011
negative regulation of nuclear division GO:0051784 3 0.011
establishment of protein localization to organelle GO:0072594 4 0.011
transcription dna templated GO:0006351 181 0.011
regulation of carbohydrate metabolic process GO:0006109 4 0.011
spermatid differentiation GO:0048515 2 0.011
cellular response to radiation GO:0071478 4 0.011
positive regulation of cell adhesion GO:0045785 1 0.011
embryonic organ development GO:0048568 381 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
cellular protein complex disassembly GO:0043624 1 0.011
positive regulation of secretion GO:0051047 1 0.011
regulation of protein catabolic process GO:0042176 1 0.011
release of sequestered calcium ion into cytosol GO:0051209 3 0.011
actin polymerization or depolymerization GO:0008154 2 0.011
post golgi vesicle mediated transport GO:0006892 1 0.011
synaptic growth at neuromuscular junction GO:0051124 2 0.011
negative regulation of cellular protein metabolic process GO:0032269 16 0.011
positive regulation of response to stimulus GO:0048584 80 0.011
atp metabolic process GO:0046034 5 0.011
cell death GO:0008219 121 0.011
Worm
thermosensory behavior GO:0040040 1 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.011
endocrine process GO:0050886 2 0.011
mitochondrion organization GO:0007005 4 0.011
cortical actin cytoskeleton organization GO:0030866 1 0.011
negative regulation of multi organism process GO:0043901 3 0.010
negative regulation of phosphate metabolic process GO:0045936 13 0.010
establishment of pigment granule localization GO:0051905 22 0.010
transmembrane transport GO:0055085 120 0.010
locomotor rhythm GO:0045475 3 0.010
cell cycle GO:0007049 93 0.010
Worm
guanosine containing compound metabolic process GO:1901068 4 0.010
cellular nitrogen compound catabolic process GO:0044270 15 0.010
phototransduction GO:0007602 2 0.010
sequestering of metal ion GO:0051238 3 0.010
negative regulation of intracellular protein transport GO:0090317 3 0.010
protein modification process GO:0036211 100 0.010
Human
purine ribonucleoside triphosphate metabolic process GO:0009205 9 0.010
negative regulation of epithelial cell proliferation GO:0050680 1 0.010
microtubule depolymerization GO:0007019 1 0.010
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.010
regulation of circadian rhythm GO:0042752 4 0.010
synaptic vesicle localization GO:0097479 1 0.010
phagocytosis engulfment GO:0006911 1 0.010
germ line stem cell maintenance GO:0030718 2 0.010
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
interspecies interaction between organisms GO:0044419 4 0.010
cell cycle process GO:0022402 53 0.010
Worm
regulation of sodium ion transport GO:0002028 2 0.010

skp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.045
cancer DOID:162 0 0.025
organ system cancer DOID:0050686 0 0.022